ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	drug catabolic process (GO:0042737)	9.93218519
2	epoxygenase P450 pathway (GO:0019373)	9.87871560
3	complement activation, alternative pathway (GO:0006957)	9.23655002
4	L-phenylalanine catabolic process (GO:0006559)	8.15990895
5	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	8.15990895
6	regulation of fibrinolysis (GO:0051917)	8.02564897
7	regulation of protein activation cascade (GO:2000257)	7.96343065
8	glyoxylate metabolic process (GO:0046487)	7.62919496
9	regulation of complement activation (GO:0030449)	7.57900386
10	negative regulation of fibrinolysis (GO:0051918)	7.53341097
11	L-phenylalanine metabolic process (GO:0006558)	7.44142256
12	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.44142256
13	ethanol oxidation (GO:0006069)	7.26631240
14	urea metabolic process (GO:0019627)	6.93440816
15	drug metabolic process (GO:0017144)	6.66713874
16	cellular glucuronidation (GO:0052695)	6.47658024
17	oxidative demethylation (GO:0070989)	6.32416078
18	nitrogen cycle metabolic process (GO:0071941)	6.31240782
19	fibrinolysis (GO:0042730)	6.21181825
20	protein carboxylation (GO:0018214)	6.16716932
21	peptidyl-glutamic acid carboxylation (GO:0017187)	6.16716932
22	glucuronate metabolic process (GO:0019585)	6.14036220
23	uronic acid metabolic process (GO:0006063)	6.14036220
24	aromatic amino acid family catabolic process (GO:0009074)	6.08207662
25	bile acid biosynthetic process (GO:0006699)	5.89426041
26	ethanol metabolic process (GO:0006067)	5.80426780
27	blood coagulation, intrinsic pathway (GO:0007597)	5.77988060
28	imidazole-containing compound metabolic process (GO:0052803)	5.75859219
29	urea cycle (GO:0000050)	5.75270999
30	serine family amino acid catabolic process (GO:0009071)	5.58778760
31	protein activation cascade (GO:0072376)	5.40075508
32	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.36886996
33	bile acid metabolic process (GO:0008206)	5.33436907
34	regulation of triglyceride catabolic process (GO:0010896)	5.33017020
35	negative regulation of cholesterol transport (GO:0032375)	5.23620353
36	negative regulation of sterol transport (GO:0032372)	5.23620353
37	complement activation (GO:0006956)	5.23525588
38	opsonization (GO:0008228)	5.18348520
39	bile acid and bile salt transport (GO:0015721)	5.10413486
40	complement activation, classical pathway (GO:0006958)	5.08699099
41	regulation of plasminogen activation (GO:0010755)	5.05178093
42	S-adenosylmethionine metabolic process (GO:0046500)	4.95152409
43	glycine metabolic process (GO:0006544)	4.90643509
44	tyrosine metabolic process (GO:0006570)	4.89723607
45	phenylpropanoid metabolic process (GO:0009698)	4.88959238
46	regulation of humoral immune response (GO:0002920)	4.79914193
47	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	4.76926893
48	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	4.76926893
49	negative regulation of protein activation cascade (GO:2000258)	4.64558036
50	negative regulation of blood coagulation (GO:0030195)	4.64283601
51	negative regulation of hemostasis (GO:1900047)	4.64283601
52	acute-phase response (GO:0006953)	4.54710118
53	cytolysis (GO:0019835)	4.54376330
54	glutamate metabolic process (GO:0006536)	4.46114815
55	alkaloid metabolic process (GO:0009820)	4.41211320
56	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	4.39368432
57	positive regulation of triglyceride lipase activity (GO:0061365)	4.35067174
58	positive regulation of lipoprotein lipase activity (GO:0051006)	4.35067174
59	triglyceride homeostasis (GO:0070328)	4.29876048
60	acylglycerol homeostasis (GO:0055090)	4.29876048
61	indole-containing compound catabolic process (GO:0042436)	4.23511454
62	indolalkylamine catabolic process (GO:0046218)	4.23511454
63	tryptophan catabolic process (GO:0006569)	4.23511454
64	negative regulation of coagulation (GO:0050819)	4.21260129
65	negative regulation of wound healing (GO:0061045)	4.17387975
66	amino-acid betaine metabolic process (GO:0006577)	4.16633779
67	flavonoid metabolic process (GO:0009812)	4.14700053
68	alpha-amino acid catabolic process (GO:1901606)	4.06288867
69	protein-lipid complex remodeling (GO:0034368)	4.01765285
70	macromolecular complex remodeling (GO:0034367)	4.01765285
71	plasma lipoprotein particle remodeling (GO:0034369)	4.01765285
72	positive regulation of hemostasis (GO:1900048)	3.96657645
73	positive regulation of blood coagulation (GO:0030194)	3.96657645
74	aromatic amino acid family metabolic process (GO:0009072)	3.94628252
75	phospholipid efflux (GO:0033700)	3.89974043
76	serine family amino acid metabolic process (GO:0009069)	3.89911543
77	hormone catabolic process (GO:0042447)	3.89217206
78	cholesterol efflux (GO:0033344)	3.85968073
79	arginine metabolic process (GO:0006525)	3.79515372
80	high-density lipoprotein particle remodeling (GO:0034375)	3.76921789
81	intestinal cholesterol absorption (GO:0030299)	3.74688183
82	response to mercury ion (GO:0046689)	3.73792570
83	sodium-independent organic anion transport (GO:0043252)	3.66882225
84	negative regulation of complement activation (GO:0045916)	3.65964212
85	cellular ketone body metabolic process (GO:0046950)	3.65213039
86	positive regulation of coagulation (GO:0050820)	3.64218967
87	xenobiotic metabolic process (GO:0006805)	3.60645237
88	negative regulation of lipase activity (GO:0060192)	3.55847892
89	tryptophan metabolic process (GO:0006568)	3.54817989
90	fat-soluble vitamin biosynthetic process (GO:0042362)	3.50138059
91	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.47864239
92	cellular amino acid catabolic process (GO:0009063)	3.44296218
93	reverse cholesterol transport (GO:0043691)	3.43324230
94	positive regulation of lipid catabolic process (GO:0050996)	3.42947537
95	regulation of cholesterol esterification (GO:0010872)	3.38591861
96	regulation of acute inflammatory response (GO:0002673)	3.36919365
97	heme transport (GO:0015886)	3.36356254
98	acute inflammatory response (GO:0002526)	3.35476186
99	exogenous drug catabolic process (GO:0042738)	10.8542778
100	omega-hydroxylase P450 pathway (GO:0097267)	10.1080613

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	6.97981995
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.93725910
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	5.85897841
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	5.84186344
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.70543871
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.69760222
7	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	4.33310334
8	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.20592616
9	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.98714966
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.52302371
11	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.15866750
12	FOXA2_19822575_ChIP-Seq_HepG2_Human	2.07530036
13	HNF4A_19822575_ChIP-Seq_HepG2_Human	2.06654205
14	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.4045053
15	HTT_18923047_ChIP-ChIP_STHdh_Human	1.94896453
16	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.92258738
17	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.48290693
18	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.43964537
19	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.41302144
20	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.39481778
21	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.33611620
22	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.23250953
23	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.16842877
24	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.01064046
25	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.00642164
26	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.99385947
27	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.99246786
28	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.97262638
29	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.95470309
30	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.91488628
31	BCAT_22108803_ChIP-Seq_LS180_Human	0.90778073
32	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.90071100
33	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.89388956
34	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.88705846
35	CBP_21632823_ChIP-Seq_H3396_Human	0.88698038
36	IRF1_19129219_ChIP-ChIP_H3396_Human	0.87452292
37	PHF8_20622853_ChIP-Seq_HELA_Human	0.87083747
38	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.85526238
39	GATA4_25053715_ChIP-Seq_YYC3_Human	0.85180161
40	GATA1_22025678_ChIP-Seq_K562_Human	0.84315279
41	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.83938918
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.83564456
43	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.81879865
44	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.80271899
45	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.79940221
46	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.78270543
47	NFYA_21822215_ChIP-Seq_K562_Human	0.77958452
48	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.77249257
49	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.75637860
50	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.74708076
51	TP53_18474530_ChIP-ChIP_U2OS_Human	0.74001370
52	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.73897414
53	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.73777284
54	AR_20517297_ChIP-Seq_VCAP_Human	0.73422465
55	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.72213960
56	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.71906925
57	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.70697251
58	CEBPB_22108803_ChIP-Seq_LS180_Human	0.68846553
59	SOX2_21211035_ChIP-Seq_LN229_Human	0.64619150
60	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.64213553
61	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.63890226
62	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.62169349
63	GATA6_25053715_ChIP-Seq_YYC3_Human	0.61646139
64	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.60417191
65	LXR_22292898_ChIP-Seq_THP-1_Human	0.59904561
66	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.59212919
67	ETV1_20927104_ChIP-Seq_GIST48_Human	0.59043693
68	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.58674382
69	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.58279349
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.57529808
71	ERG_20517297_ChIP-Seq_VCAP_Human	0.57427772
72	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.56697741
73	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.56697741
74	ER_23166858_ChIP-Seq_MCF-7_Human	0.56570797
75	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.55546680
76	SPI1_20517297_ChIP-Seq_HL60_Human	0.55226597
77	CLOCK_20551151_ChIP-Seq_293T_Human	0.54832296
78	NFYB_21822215_ChIP-Seq_K562_Human	0.54332605
79	CDX2_22108803_ChIP-Seq_LS180_Human	0.54302586
80	RAC3_21632823_ChIP-Seq_H3396_Human	0.54076393
81	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.53239451
82	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.53066979
83	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.53027972
84	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.52801436
85	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.52104092
86	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.50571791
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.50305302
88	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.50207261
89	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.50077777
90	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.48888045
91	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.48704482
92	TAF2_19829295_ChIP-Seq_ESCs_Human	0.48375870
93	P53_21459846_ChIP-Seq_SAOS-2_Human	0.47951592
94	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.47736221
95	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.47629395
96	MYC_19829295_ChIP-Seq_ESCs_Human	0.47448379
97	SOX2_20726797_ChIP-Seq_SW620_Human	0.47305319
98	SMC4_20622854_ChIP-Seq_HELA_Human	0.46719333
99	ESRRB_18555785_Chip-Seq_ESCs_Mouse	0.46212406
100	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.46138082

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	9.90517742
2	MP0005085_abnormal_gallbladder_physiolo	6.47562021
3	MP0005360_urolithiasis	6.06346318
4	MP0008875_abnormal_xenobiotic_pharmacok	6.04840423
5	MP0005365_abnormal_bile_salt	5.77593432
6	MP0003195_calcinosis	4.91438173
7	MP0003252_abnormal_bile_duct	4.55324341
8	MP0002138_abnormal_hepatobiliary_system	4.36603568
9	MP0001666_abnormal_nutrient_absorption	3.23471590
10	MP0003868_abnormal_feces_composition	2.91393337
11	MP0010329_abnormal_lipoprotein_level	2.82546184
12	MP0003191_abnormal_cellular_cholesterol	2.45305890
13	MP0005332_abnormal_amino_acid	2.40845470
14	MP0009697_abnormal_copulation	2.38960665
15	MP0003806_abnormal_nucleotide_metabolis	2.19195355
16	MP0010368_abnormal_lymphatic_system	2.05744558
17	MP0000609_abnormal_liver_physiology	1.91394207
18	MP0009840_abnormal_foam_cell	1.82947493
19	MP0002118_abnormal_lipid_homeostasis	1.67836428
20	MP0002876_abnormal_thyroid_physiology	1.63145520
21	MP0005670_abnormal_white_adipose	1.56484257
22	MP0001764_abnormal_homeostasis	1.46763148
23	MP0001661_extended_life_span	1.40147912
24	MP0009053_abnormal_anal_canal	1.26330863
25	MP0003656_abnormal_erythrocyte_physiolo	1.17177156
26	MP0004019_abnormal_vitamin_homeostasis	1.16835656
27	MP0002132_abnormal_respiratory_system	1.16155960
28	MP0005408_hypopigmentation	1.16090318
29	MP0005319_abnormal_enzyme/_coenzyme	1.14996061
30	MP0000598_abnormal_liver_morphology	1.08644537
31	MP0009764_decreased_sensitivity_to	1.02216172
32	MP0005584_abnormal_enzyme/coenzyme_acti	0.99874150
33	MP0009643_abnormal_urine_homeostasis	0.96947492
34	MP0009763_increased_sensitivity_to	0.92724237
35	MP0005451_abnormal_body_composition	0.91578952
36	MP0002282_abnormal_trachea_morphology	0.90922417
37	MP0002971_abnormal_brown_adipose	0.87263393
38	MP0008469_abnormal_protein_level	0.82511737
39	MP0009642_abnormal_blood_homeostasis	0.82201118
40	MP0000604_amyloidosis	0.80027876
41	MP0008872_abnormal_physiological_respon	0.78760912
42	MP0001915_intracranial_hemorrhage	0.78475755
43	MP0005376_homeostasis/metabolism_phenot	0.78212467
44	MP0003690_abnormal_glial_cell	0.74926888
45	MP0005636_abnormal_mineral_homeostasis	0.70652235
46	MP0005187_abnormal_penis_morphology	0.70580869
47	MP0005535_abnormal_body_temperature	0.70066060
48	MP0002249_abnormal_larynx_morphology	0.69830353
49	MP0005395_other_phenotype	0.69477543
50	MP0003186_abnormal_redox_activity	0.66741957
51	MP0003879_abnormal_hair_cell	0.64680267
52	MP0002168_other_aberrant_phenotype	0.64208693
53	MP0005266_abnormal_metabolism	0.62437045
54	MP0005464_abnormal_platelet_physiology	0.61844107
55	MP0002078_abnormal_glucose_homeostasis	0.58817323
56	MP0005023_abnormal_wound_healing	0.58022761
57	MP0004130_abnormal_muscle_cell	0.57799716
58	MP0003011_delayed_dark_adaptation	0.57460953
59	MP0008874_decreased_physiological_sensi	0.57279257
60	MP0005334_abnormal_fat_pad	0.56496097
61	MP0009785_altered_susceptibility_to	0.55223082
62	MP0004782_abnormal_surfactant_physiolog	0.54406443
63	MP0009765_abnormal_xenobiotic_induced	0.51369343
64	MP0005166_decreased_susceptibility_to	0.50120996
65	MP0003638_abnormal_response/metabolism_	0.49182677
66	MP0002332_abnormal_exercise_endurance	0.41369298
67	MP0003075_altered_response_to	0.41339415
68	MP0000467_abnormal_esophagus_morphology	0.38466416
69	MP0000249_abnormal_blood_vessel	0.37463204
70	MP0004883_abnormal_blood_vessel	0.37013679
71	MP0005448_abnormal_energy_balance	0.36408933
72	MP0005164_abnormal_response_to	0.36002075
73	MP0003705_abnormal_hypodermis_morpholog	0.35906262
74	MP0002136_abnormal_kidney_physiology	0.34922026
75	MP0006036_abnormal_mitochondrial_physio	0.34225266
76	MP0000566_synostosis	0.30805186
77	MP0005220_abnormal_exocrine_pancreas	0.30572270
78	MP0001851_eye_inflammation	0.29096043
79	MP0005647_abnormal_sex_gland	0.28613161
80	MP0005397_hematopoietic_system_phenotyp	0.27481538
81	MP0001545_abnormal_hematopoietic_system	0.27481538
82	MP0005666_abnormal_adipose_tissue	0.27424938
83	MP0009115_abnormal_fat_cell	0.27298443
84	MP0000639_abnormal_adrenal_gland	0.27209049
85	MP0003953_abnormal_hormone_level	0.25375928
86	MP0001845_abnormal_inflammatory_respons	0.23963181
87	MP0003718_maternal_effect	0.23141243
88	MP0001881_abnormal_mammary_gland	0.22650188
89	MP0001756_abnormal_urination	0.21093328
90	MP0002128_abnormal_blood_circulation	0.20297665
91	MP0008873_increased_physiological_sensi	0.19783930
92	MP0003436_decreased_susceptibility_to	0.19438849
93	MP0002928_abnormal_bile_duct	0.18789661
94	MP0005058_abnormal_lysosome_morphology	0.17625286
95	MP0003959_abnormal_lean_body	0.17374940
96	MP0003632_abnormal_nervous_system	0.17011275
97	MP0005083_abnormal_biliary_tract	0.16688090
98	MP0010155_abnormal_intestine_physiology	0.16347134
99	MP0000920_abnormal_myelination	0.15367461
100	MP0005197_abnormal_uvea_morphology	0.15212542

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	9.15102373
2	Prolonged partial thromboplastin time (HP:0003645)	8.80763499
3	Abnormality of complement system (HP:0005339)	8.55370812
4	Abnormality of aromatic amino acid family metabolism (HP:0004338)	8.54564462
5	Conjugated hyperbilirubinemia (HP:0002908)	8.17135115
6	Hypobetalipoproteinemia (HP:0003563)	7.58256334
7	Systemic lupus erythematosus (HP:0002725)	6.24237772
8	Joint hemorrhage (HP:0005261)	6.12891412
9	Hyperlipoproteinemia (HP:0010980)	5.79592998
10	Glomerulonephritis (HP:0000099)	5.77395837
11	Intrahepatic cholestasis (HP:0001406)	5.68413400
12	Recurrent gram-negative bacterial infections (HP:0005420)	4.93965361
13	Abnormality of the common coagulation pathway (HP:0010990)	4.80849837
14	Abnormality of pyrimidine metabolism (HP:0004353)	4.80085411
15	Xanthomatosis (HP:0000991)	4.73871598
16	Spontaneous abortion (HP:0005268)	4.60888759
17	Hypolipoproteinemia (HP:0010981)	4.41566164
18	Nephritis (HP:0000123)	4.21885468
19	Abnormality of the intrinsic pathway (HP:0010989)	4.21453457
20	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.89640809
21	Fat malabsorption (HP:0002630)	3.58062002
22	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.52973342
23	Hypoalphalipoproteinemia (HP:0003233)	3.47258071
24	Abnormality of methionine metabolism (HP:0010901)	3.44792189
25	Hyperglycinemia (HP:0002154)	3.12418930
26	Hyperammonemia (HP:0001987)	3.09510968
27	Gingival bleeding (HP:0000225)	3.05979278
28	Neonatal hypoglycemia (HP:0001998)	3.04835425
29	Hypercholesterolemia (HP:0003124)	2.96192351
30	Mitral stenosis (HP:0001718)	2.94714763
31	Delayed CNS myelination (HP:0002188)	2.84348263
32	Fair hair (HP:0002286)	2.83642442
33	Generalized aminoaciduria (HP:0002909)	2.81962935
34	Hyperbilirubinemia (HP:0002904)	2.81330018
35	Abnormality of serine family amino acid metabolism (HP:0010894)	2.76289101
36	Abnormality of glycine metabolism (HP:0010895)	2.76289101
37	Vascular calcification (HP:0004934)	2.75426015
38	Thrombophlebitis (HP:0004418)	2.68505187
39	Hemorrhage of the eye (HP:0011885)	2.67416661
40	Epidermoid cyst (HP:0200040)	2.66580003
41	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.66102029
42	Rickets (HP:0002748)	2.65568879
43	Hepatocellular carcinoma (HP:0001402)	2.65156239
44	Abnormality of nucleobase metabolism (HP:0010932)	2.64958378
45	Osteomalacia (HP:0002749)	2.63836792
46	Steatorrhea (HP:0002570)	2.55530268
47	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.46432528
48	Cardiovascular calcification (HP:0011915)	2.44939010
49	Abnormality of serum amino acid levels (HP:0003112)	2.42799329
50	Purpura (HP:0000979)	2.36862526
51	Hyperglycinuria (HP:0003108)	2.34655518
52	Cholelithiasis (HP:0001081)	2.31459755
53	Pulmonary embolism (HP:0002204)	2.26212228
54	Abnormal gallbladder morphology (HP:0012437)	2.15516876
55	Menorrhagia (HP:0000132)	2.12690462
56	Elevated alkaline phosphatase (HP:0003155)	2.08383342
57	Joint swelling (HP:0001386)	2.03243821
58	Metabolic acidosis (HP:0001942)	2.00683880
59	Generalized hypopigmentation of hair (HP:0011358)	2.00062440
60	Complement deficiency (HP:0004431)	10.5910665
61	Abnormality of monocarboxylic acid metabolism (HP:0010996)	10.3234149
62	Abnormality of vitamin metabolism (HP:0100508)	1.98386357
63	Myocardial infarction (HP:0001658)	1.95262925
64	Abnormal enzyme/coenzyme activity (HP:0012379)	1.93365241
65	Ketosis (HP:0001946)	1.93287556
66	Hyperphosphaturia (HP:0003109)	1.93055792
67	Abnormality of alkaline phosphatase activity (HP:0004379)	1.88419159
68	Abnormal gallbladder physiology (HP:0012438)	1.84840888
69	Cholecystitis (HP:0001082)	1.84840888
70	Arthropathy (HP:0003040)	1.83495196
71	Increased mean platelet volume (HP:0011877)	1.80986398
72	Irritability (HP:0000737)	1.80655451
73	Blue irides (HP:0000635)	1.79700248
74	Abnormality of iron homeostasis (HP:0011031)	1.77936400
75	Increased serum ferritin (HP:0003281)	1.77016381
76	Abnormality of the Achilles tendon (HP:0005109)	1.75179095
77	Epistaxis (HP:0000421)	1.74428827
78	Bifid scrotum (HP:0000048)	1.74402637
79	Hypophosphatemic rickets (HP:0004912)	1.74141245
80	Abnormality of urine glucose concentration (HP:0011016)	1.73641860
81	Glycosuria (HP:0003076)	1.73641860
82	Reduced antithrombin III activity (HP:0001976)	1.69590396
83	Hypochromic microcytic anemia (HP:0004840)	1.69431192
84	Poikilocytosis (HP:0004447)	1.67321417
85	Cerebral palsy (HP:0100021)	1.67219878
86	Abnormality of purine metabolism (HP:0004352)	1.66358488
87	Skin nodule (HP:0200036)	1.66099036
88	Abnormal platelet volume (HP:0011876)	1.64042529
89	Gangrene (HP:0100758)	1.63743122
90	Abnormality of transition element cation homeostasis (HP:0011030)	1.62834551
91	Abnormal urine phosphate concentration (HP:0012599)	1.55943722
92	Hydroxyprolinuria (HP:0003080)	1.55869086
93	Abnormality of proline metabolism (HP:0010907)	1.55869086
94	Abnormality of the gallbladder (HP:0005264)	1.53612898
95	Gout (HP:0001997)	1.52578012
96	Abnormal biliary tract physiology (HP:0012439)	1.50585131
97	Bile duct proliferation (HP:0001408)	1.50585131
98	Reticulocytosis (HP:0001923)	1.48275527
99	Alkalosis (HP:0001948)	1.47971716
100	Abnormal delivery (HP:0001787)	1.47959404

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	5.52655523
2	PIK3CG	4.09076857
3	FGFR4	3.95918014
4	SIK1	3.26109534
5	RIPK1	2.95258533
6	TRIB3	2.94932843
7	TYK2	2.80816732
8	EPHA3	2.60458313
9	PIK3CA	2.32549483
10	PRKACG	2.23830958
11	PRKAA2	2.06109943
12	BCKDK	1.94225682
13	FGFR3	1.88765761
14	PRPF4B	1.86895554
15	MAP2K4	1.78212489
16	AKT3	1.74555438
17	MAPK11	1.73157987
18	TNK2	1.69766831
19	MST1R	1.65137043
20	TAOK3	1.63617023
21	JAK1	1.57226617
22	NTRK3	1.56789216
23	FER	1.56731099
24	NLK	1.48236526
25	NEK9	1.47403666
26	IGF1R	1.43313157
27	MAP3K3	1.30669392
28	MAP3K2	1.28369489
29	ICK	1.25232264
30	ERBB2	1.22183766
31	PDPK1	1.20071604
32	EPHB1	1.19962031
33	TBK1	1.15878369
34	PRKCG	1.13556473
35	CAMKK2	1.11335476
36	ABL2	1.08714510
37	JAK2	1.05364857
38	CSF1R	0.96779259
39	PRKCZ	0.96446147
40	MAP3K1	0.91646574
41	KDR	0.90150795
42	PRKAA1	0.90025593
43	RET	0.89778141
44	PRKG1	0.87685384
45	PDK1	0.85251245
46	TIE1	0.81895101
47	PRKACA	0.79359190
48	MYLK	0.79080600
49	CDK6	0.76980617
50	MET	0.76119668
51	SCYL2	0.70895194
52	MAPK7	0.70230006
53	EPHA4	0.68411752
54	SGK3	0.68189393
55	CAMK1D	0.66857297
56	DYRK1B	0.66652200
57	IRAK3	0.66325313
58	PKN2	0.65243812
59	ZAP70	0.64565099
60	SGK2	0.62582046
61	INSRR	0.62381545
62	MAP3K6	0.62085903
63	BRSK2	0.60106277
64	MAPK12	0.59448969
65	MAPK4	0.58418849
66	ERBB4	0.57959390
67	TGFBR2	0.57379805
68	SGK223	0.57258138
69	SGK494	0.57258138
70	DAPK2	0.54174025
71	RPS6KA3	0.53950192
72	KSR2	0.52646561
73	PDK2	0.52643312
74	CSNK1E	0.51906330
75	PINK1	0.51703589
76	PRKCB	0.51336039
77	CSNK1D	0.51312886
78	STK38	0.51305081
79	PRKCA	0.50702711
80	SRC	0.49315537
81	BLK	0.48653724
82	MAP3K11	0.46609375
83	CAMKK1	0.46077370
84	MAP3K13	0.45614667
85	PRKACB	0.44479770
86	MTOR	0.42479098
87	PTK6	0.41622369
88	GSK3A	0.40213446
89	FRK	0.40107251
90	IKBKE	0.40082318
91	PDGFRA	0.39973389
92	SGK1	0.38631087
93	KIT	0.38427700
94	TAOK2	0.35616939
95	MAPK3	0.31955315
96	CSNK2A1	0.31853060
97	CAMK2G	0.30061212
98	SMG1	0.28914869
99	GRK1	0.27479119
100	FGFR2	0.26526732

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.54299258
2	Caffeine metabolism_Homo sapiens_hsa00232	4.50146056
3	Complement and coagulation cascades_Homo sapiens_hsa04610	3.88225425
4	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.58887685
5	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.57496134
6	Retinol metabolism_Homo sapiens_hsa00830	3.51304688
7	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.49387059
8	Chemical carcinogenesis_Homo sapiens_hsa05204	2.98153393
9	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.96679445
10	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.68836672
11	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.60596516
12	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.57538968
13	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.55278426
14	Arginine biosynthesis_Homo sapiens_hsa00220	2.52354117
15	Fatty acid degradation_Homo sapiens_hsa00071	2.51842214
16	Tyrosine metabolism_Homo sapiens_hsa00350	2.47946132
17	Phenylalanine metabolism_Homo sapiens_hsa00360	2.46530025
18	Histidine metabolism_Homo sapiens_hsa00340	2.05419116
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.97111761
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.95724154
21	Butanoate metabolism_Homo sapiens_hsa00650	1.87594756
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.86185648
23	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.82269462
24	Bile secretion_Homo sapiens_hsa04976	1.73949709
25	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.58029440
26	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.43732742
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.43471373
28	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.42906200
29	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.42377556
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.38290084
31	Prion diseases_Homo sapiens_hsa05020	1.37358989
32	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.31253574
33	PPAR signaling pathway_Homo sapiens_hsa03320	1.30939560
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.27607002
35	beta-Alanine metabolism_Homo sapiens_hsa00410	1.18500290
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.17345669
37	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.11716320
38	Peroxisome_Homo sapiens_hsa04146	1.10858613
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.08807444
40	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.98092706
41	Pyruvate metabolism_Homo sapiens_hsa00620	0.97243019
42	ABC transporters_Homo sapiens_hsa02010	0.90111821
43	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.88984363
44	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.87129357
45	Arginine and proline metabolism_Homo sapiens_hsa00330	0.83974871
46	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.82737634
47	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.82112829
48	One carbon pool by folate_Homo sapiens_hsa00670	0.81196664
49	Carbon metabolism_Homo sapiens_hsa01200	0.78032230
50	Propanoate metabolism_Homo sapiens_hsa00640	0.77318198
51	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.71843489
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.71231926
53	Fatty acid metabolism_Homo sapiens_hsa01212	0.66642219
54	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.58694473
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.52744209
56	Lysine degradation_Homo sapiens_hsa00310	0.41471675
57	Metabolic pathways_Homo sapiens_hsa01100	0.39024934
58	Pertussis_Homo sapiens_hsa05133	0.34804349
59	Sulfur metabolism_Homo sapiens_hsa00920	0.27840045
60	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.27203657
61	Insulin resistance_Homo sapiens_hsa04931	0.26573149
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.25774846
63	Sulfur relay system_Homo sapiens_hsa04122	0.19559592
64	Glucagon signaling pathway_Homo sapiens_hsa04922	0.18162010
65	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.17975692
66	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.15589807
67	Pentose phosphate pathway_Homo sapiens_hsa00030	0.15349939
68	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.13207357
69	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.12033563
70	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.11030986
71	AMPK signaling pathway_Homo sapiens_hsa04152	0.04060928
72	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.03940200
73	Amoebiasis_Homo sapiens_hsa05146	0.02225812
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.01572030
75	Fatty acid elongation_Homo sapiens_hsa00062	0.00498316
76	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.2883869
77	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.2869802
78	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.2773493
79	FoxO signaling pathway_Homo sapiens_hsa04068	-0.2700706
80	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.2524055
81	Type II diabetes mellitus_Homo sapiens_hsa04930	-0.2408195
82	Sphingolipid metabolism_Homo sapiens_hsa00600	-0.2335615
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.2234818
84	Vascular smooth muscle contraction_Homo sapiens_hsa04270	-0.2077953
85	Circadian rhythm_Homo sapiens_hsa04710	-0.1956015
86	Glycerophospholipid metabolism_Homo sapiens_hsa00564	-0.1560110
87	Nitrogen metabolism_Homo sapiens_hsa00910	-0.1475827
88	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1278529
89	African trypanosomiasis_Homo sapiens_hsa05143	-0.1200129
90	Steroid biosynthesis_Homo sapiens_hsa00100	-0.1109262
91	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.0791225
92	Other glycan degradation_Homo sapiens_hsa00511	-0.0742281
93	Folate biosynthesis_Homo sapiens_hsa00790	-0.0651115
94	Renin-angiotensin system_Homo sapiens_hsa04614	-0.0349546
95	Galactose metabolism_Homo sapiens_hsa00052	-0.0307031
96	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.0300631
97	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	-0.0211609
98	Glutathione metabolism_Homo sapiens_hsa00480	-0.0180825
99	Mineral absorption_Homo sapiens_hsa04978	-0.0088600
100	Serotonergic synapse_Homo sapiens_hsa04726	-0.0005334

MTND4P20

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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