MTND4P32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cobalamin metabolic process (GO:0009235)5.68433948
2DNA strand renaturation (GO:0000733)5.56996535
3regulation of meiosis I (GO:0060631)5.25668781
4negative regulation of DNA-dependent DNA replication (GO:2000104)5.25353667
5N-terminal protein amino acid acetylation (GO:0006474)4.44561734
6regulation of hexokinase activity (GO:1903299)4.36958733
7regulation of glucokinase activity (GO:0033131)4.36958733
8replication fork processing (GO:0031297)4.27948772
9cholesterol biosynthetic process (GO:0006695)4.20696893
10regulation of helicase activity (GO:0051095)4.08531518
11N-terminal protein amino acid modification (GO:0031365)3.98411882
12sterol biosynthetic process (GO:0016126)3.98393032
13negative regulation of DNA recombination (GO:0045910)3.84560294
14establishment of protein localization to mitochondrial membrane (GO:0090151)3.79312288
15maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.76699205
16respiratory chain complex IV assembly (GO:0008535)3.66896700
17positive regulation of meiotic cell cycle (GO:0051446)3.64607554
18cell wall macromolecule catabolic process (GO:0016998)3.62983230
19mitotic sister chromatid cohesion (GO:0007064)3.55934981
20regulation of double-strand break repair via homologous recombination (GO:0010569)3.54875562
21regulation of cholesterol esterification (GO:0010872)3.54872008
22negative regulation of acute inflammatory response (GO:0002674)3.52101182
23histone H2A acetylation (GO:0043968)3.48718329
24cytochrome complex assembly (GO:0017004)3.45439039
25transepithelial transport (GO:0070633)3.41842310
26vitamin transport (GO:0051180)3.41338356
27somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.34902109
28isotype switching (GO:0045190)3.34902109
29somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.34902109
30positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.34058971
31mitotic recombination (GO:0006312)3.33364057
32nucleobase biosynthetic process (GO:0046112)3.33183970
33sperm capacitation (GO:0048240)3.31918795
34positive regulation of actin filament depolymerization (GO:0030836)3.25500245
35regulation of cytokine secretion involved in immune response (GO:0002739)3.25414231
36DNA double-strand break processing (GO:0000729)3.24946861
37resolution of meiotic recombination intermediates (GO:0000712)3.20803223
38regulation of mitochondrial translation (GO:0070129)3.18838201
39chaperone-mediated protein complex assembly (GO:0051131)3.17899368
40chromatin remodeling at centromere (GO:0031055)3.16938970
41nuclear pore organization (GO:0006999)3.15273767
42negative regulation of viral entry into host cell (GO:0046597)3.11221665
43transcytosis (GO:0045056)3.06816498
44preassembly of GPI anchor in ER membrane (GO:0016254)3.05863568
45myelin assembly (GO:0032288)3.05677100
46CENP-A containing nucleosome assembly (GO:0034080)3.04610404
47purine nucleobase biosynthetic process (GO:0009113)3.03211009
48DNA replication checkpoint (GO:0000076)3.01460384
49DNA replication initiation (GO:0006270)2.99914161
50centriole replication (GO:0007099)2.98703725
51telomere maintenance via semi-conservative replication (GO:0032201)2.96560272
52DNA strand elongation involved in DNA replication (GO:0006271)2.96316184
53nuclear pore complex assembly (GO:0051292)2.95437722
54protein K11-linked deubiquitination (GO:0035871)2.94986182
55cell wall macromolecule metabolic process (GO:0044036)2.94123819
56histone exchange (GO:0043486)2.87607893
57telomere maintenance via recombination (GO:0000722)2.86682701
58regulation of mitotic spindle checkpoint (GO:1903504)2.85700971
59regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.85700971
60high-density lipoprotein particle remodeling (GO:0034375)2.83559319
61telomere maintenance via telomerase (GO:0007004)2.83345346
62vitamin A metabolic process (GO:0006776)2.82122269
63double-strand break repair via homologous recombination (GO:0000724)2.81904685
64homocysteine metabolic process (GO:0050667)2.78759107
65translesion synthesis (GO:0019985)2.78724898
66recombinational repair (GO:0000725)2.77420618
67positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.75360323
68glycine metabolic process (GO:0006544)2.74806079
69nucleotide-excision repair, DNA gap filling (GO:0006297)2.72834045
70regulation of sister chromatid cohesion (GO:0007063)2.72546891
71ribosome assembly (GO:0042255)2.71158996
72mitotic G2/M transition checkpoint (GO:0044818)2.70404691
73DNA strand elongation (GO:0022616)2.68668211
74urate metabolic process (GO:0046415)2.67231109
75aspartate family amino acid catabolic process (GO:0009068)2.66607146
76protein localization to kinetochore (GO:0034501)2.66604739
77meiotic chromosome segregation (GO:0045132)2.64974318
78tetrapyrrole metabolic process (GO:0033013)2.64472718
79phospholipid efflux (GO:0033700)2.63195287
80DNA damage response, signal transduction resulting in transcription (GO:0042772)2.61281025
81blastocyst development (GO:0001824)2.58712372
82rRNA methylation (GO:0031167)2.58254851
83rRNA modification (GO:0000154)2.57424889
84postreplication repair (GO:0006301)2.56747297
85adenosine metabolic process (GO:0046085)2.55032334
86negative regulation of lipase activity (GO:0060192)2.53854629
87regulation of centrosome cycle (GO:0046605)2.53035285
88inner mitochondrial membrane organization (GO:0007007)2.48760101
89transcription from RNA polymerase III promoter (GO:0006383)2.48649763
90negative regulation of translational initiation (GO:0045947)2.48399598
91fibroblast migration (GO:0010761)2.47738394
92regulation of centriole replication (GO:0046599)2.47660034
93proteasome assembly (GO:0043248)2.45402288
94positive regulation of meiosis (GO:0045836)2.45242019
95pancreas development (GO:0031016)2.44125527
96somatic diversification of immune receptors via somatic mutation (GO:0002566)2.43888136
97somatic hypermutation of immunoglobulin genes (GO:0016446)2.43888136
98branched-chain amino acid catabolic process (GO:0009083)2.43208459
99positive regulation of glycolytic process (GO:0045821)2.42586954
100double-strand break repair (GO:0006302)2.42035638

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.57579079
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.84208616
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.87113452
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.64745521
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.10332868
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.04928396
7ZNF274_21170338_ChIP-Seq_K562_Hela2.94126025
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.92717211
9VDR_22108803_ChIP-Seq_LS180_Human2.78139110
10ELK1_19687146_ChIP-ChIP_HELA_Human2.66718651
11FUS_26573619_Chip-Seq_HEK293_Human2.39225808
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25089237
13GBX2_23144817_ChIP-Seq_PC3_Human2.14324786
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11652866
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.10229071
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08619536
17AR_21909140_ChIP-Seq_LNCAP_Human1.99646734
18EWS_26573619_Chip-Seq_HEK293_Human1.98862619
19PADI4_21655091_ChIP-ChIP_MCF-7_Human1.94560943
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.93567222
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89010485
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81589305
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80448492
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75329057
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.73294478
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.72525051
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.71501465
28VDR_23849224_ChIP-Seq_CD4+_Human1.70633005
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70238994
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.59988888
31TAF15_26573619_Chip-Seq_HEK293_Human1.54326479
32P300_19829295_ChIP-Seq_ESCs_Human1.54320387
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51698785
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45836025
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44741960
36PHF8_20622853_ChIP-Seq_HELA_Human1.43947214
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42334954
38BCAT_22108803_ChIP-Seq_LS180_Human1.42159526
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39703261
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.39383544
41FOXP3_21729870_ChIP-Seq_TREG_Human1.39249121
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39128323
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36116780
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35936714
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32597283
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.32387002
47FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26733943
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26227762
49CBP_20019798_ChIP-Seq_JUKART_Human1.26227762
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.26140509
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25633334
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23624661
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22772397
54NANOG_16153702_ChIP-ChIP_HESCs_Human1.21205231
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20765673
56TP53_16413492_ChIP-PET_HCT116_Human1.19021929
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.18765198
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17793100
59MYC_18940864_ChIP-ChIP_HL60_Human1.17788026
60TP53_22573176_ChIP-Seq_HFKS_Human1.17189686
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15845712
62ER_23166858_ChIP-Seq_MCF-7_Human1.14528835
63CDX2_22108803_ChIP-Seq_LS180_Human1.14345554
64RBPJ_21746931_ChIP-Seq_IB4_Human1.14139697
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12781782
66CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.11948361
67SOX2_19829295_ChIP-Seq_ESCs_Human1.10762155
68NANOG_19829295_ChIP-Seq_ESCs_Human1.10762155
69ETV1_20927104_ChIP-Seq_GIST48_Human1.10687054
70TCF4_22108803_ChIP-Seq_LS180_Human1.09981542
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.09558912
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09411563
73PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08005565
74NFYB_21822215_ChIP-Seq_K562_Human1.07757039
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06281330
76SMAD4_21799915_ChIP-Seq_A2780_Human1.05349388
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05150517
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.04675724
79IGF1R_20145208_ChIP-Seq_DFB_Human1.04658947
80HNFA_21074721_ChIP-Seq_CACO-2_Human1.04164850
81STAT3_23295773_ChIP-Seq_U87_Human1.03526613
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03204249
83TCF4_23295773_ChIP-Seq_U87_Human1.01961674
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.01387324
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00975183
86SALL4_22934838_ChIP-ChIP_CD34+_Human1.00446694
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.00075822
88ESR1_21235772_ChIP-Seq_MCF-7_Human0.98819948
89PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98003570
90NFYA_21822215_ChIP-Seq_K562_Human0.97090887
91FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97030201
92MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96911808
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96890038
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96615475
95ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96286579
96GATA6_21074721_ChIP-Seq_CACO-2_Human0.95615083
97IRF1_19129219_ChIP-ChIP_H3396_Human0.95444190
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95242623
99CBX2_22325352_ChIP-Seq_293T-Rex_Human0.94987155
100HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94567241

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology4.27666761
2MP0002132_abnormal_respiratory_system3.53971904
3MP0002277_abnormal_respiratory_mucosa3.11177657
4MP0005220_abnormal_exocrine_pancreas2.92776099
5MP0003950_abnormal_plasma_membrane2.78566463
6MP0003890_abnormal_embryonic-extraembry2.74637027
7MP0003693_abnormal_embryo_hatching2.62596065
8MP0008058_abnormal_DNA_repair2.61057399
9MP0009697_abnormal_copulation2.57746470
10MP0010094_abnormal_chromosome_stability2.57423260
11MP0003011_delayed_dark_adaptation2.42744346
12MP0005379_endocrine/exocrine_gland_phen2.41203561
13MP0002138_abnormal_hepatobiliary_system2.36256831
14MP0002938_white_spotting2.34603840
15MP0003646_muscle_fatigue2.27368302
16MP0005410_abnormal_fertilization2.21823050
17MP0003300_gastrointestinal_ulcer2.14800652
18MP0010307_abnormal_tumor_latency2.06518038
19MP0010386_abnormal_urinary_bladder1.91370879
20MP0008875_abnormal_xenobiotic_pharmacok1.90729605
21MP0000569_abnormal_digit_pigmentation1.85089310
22MP0003195_calcinosis1.84579412
23MP0000462_abnormal_digestive_system1.84315586
24MP0003806_abnormal_nucleotide_metabolis1.83234114
25MP0002876_abnormal_thyroid_physiology1.83229110
26MP0004043_abnormal_pH_regulation1.82694471
27MP0006292_abnormal_olfactory_placode1.80898885
28MP0000427_abnormal_hair_cycle1.77359227
29MP0008872_abnormal_physiological_respon1.76912598
30MP0002089_abnormal_postnatal_growth/wei1.75933146
31MP0006054_spinal_hemorrhage1.73316650
32MP0003786_premature_aging1.69751224
33MP0009840_abnormal_foam_cell1.67877990
34MP0005395_other_phenotype1.64357918
35MP0008932_abnormal_embryonic_tissue1.63623433
36MP0008057_abnormal_DNA_replication1.62372225
37MP0008007_abnormal_cellular_replicative1.61485468
38MP0000372_irregular_coat_pigmentation1.59263236
39MP0010030_abnormal_orbit_morphology1.52940785
40MP0004381_abnormal_hair_follicle1.49980457
41MP0010352_gastrointestinal_tract_polyps1.40400185
42MP0000647_abnormal_sebaceous_gland1.37981262
43MP0003941_abnormal_skin_development1.33962043
44MP0005083_abnormal_biliary_tract1.32073739
45MP0003077_abnormal_cell_cycle1.30852436
46MP0003718_maternal_effect1.28610171
47MP0003111_abnormal_nucleus_morphology1.25561212
48MP0002396_abnormal_hematopoietic_system1.25531526
49MP0001929_abnormal_gametogenesis1.21223132
50MP0000538_abnormal_urinary_bladder1.20999186
51MP0003283_abnormal_digestive_organ1.20574624
52MP0001666_abnormal_nutrient_absorption1.20328083
53MP0005551_abnormal_eye_electrophysiolog1.19945212
54MP0008877_abnormal_DNA_methylation1.15947514
55MP0004019_abnormal_vitamin_homeostasis1.11251135
56MP0002210_abnormal_sex_determination1.09737540
57MP0000631_abnormal_neuroendocrine_gland1.09030140
58MP0001764_abnormal_homeostasis1.06296923
59MP0000516_abnormal_urinary_system1.06104912
60MP0005367_renal/urinary_system_phenotyp1.06104912
61MP0003656_abnormal_erythrocyte_physiolo1.06049156
62MP0002928_abnormal_bile_duct1.04189901
63MP0000566_synostosis1.02258576
64MP0001119_abnormal_female_reproductive1.02040181
65MP0005670_abnormal_white_adipose1.01878783
66MP0001177_atelectasis1.00856602
67MP0005408_hypopigmentation1.00239781
68MP0000653_abnormal_sex_gland0.99957093
69MP0005636_abnormal_mineral_homeostasis0.98246465
70MP0004957_abnormal_blastocyst_morpholog0.96015887
71MP0000613_abnormal_salivary_gland0.95780192
72MP0004084_abnormal_cardiac_muscle0.95292435
73MP0005075_abnormal_melanosome_morpholog0.92191667
74MP0001145_abnormal_male_reproductive0.89739354
75MP0004215_abnormal_myocardial_fiber0.89031014
76MP0001188_hyperpigmentation0.88691888
77MP0002796_impaired_skin_barrier0.88575154
78MP0000537_abnormal_urethra_morphology0.86177518
79MP0008775_abnormal_heart_ventricle0.85689021
80MP0002233_abnormal_nose_morphology0.84694462
81MP0005646_abnormal_pituitary_gland0.83093920
82MP0003880_abnormal_central_pattern0.80575907
83MP0004147_increased_porphyrin_level0.80289118
84MP0002168_other_aberrant_phenotype0.79934317
85MP0005377_hearing/vestibular/ear_phenot0.79860327
86MP0003878_abnormal_ear_physiology0.79860327
87MP0004142_abnormal_muscle_tone0.79048110
88MP0002090_abnormal_vision0.76401013
89MP0003698_abnormal_male_reproductive0.75996147
90MP0000604_amyloidosis0.75424747
91MP0000358_abnormal_cell_content/0.73365311
92MP0005174_abnormal_tail_pigmentation0.72964468
93MP0005084_abnormal_gallbladder_morpholo0.72739656
94MP0005332_abnormal_amino_acid0.72698932
95MP0008995_early_reproductive_senescence0.69637924
96MP0001293_anophthalmia0.69573239
97MP0002234_abnormal_pharynx_morphology0.68496930
98MP0006035_abnormal_mitochondrial_morpho0.67616297
99MP0005167_abnormal_blood-brain_barrier0.66165988
100MP0001697_abnormal_embryo_size0.65927986

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)5.09038744
2Male infertility (HP:0003251)4.24863767
3Duplicated collecting system (HP:0000081)3.96036675
4Abnormality of chromosome stability (HP:0003220)3.92343359
5Abnormality of the pons (HP:0007361)3.71675835
6Hepatocellular necrosis (HP:0001404)3.63010310
73-Methylglutaconic aciduria (HP:0003535)3.50922249
8Chromsome breakage (HP:0040012)3.50595216
9Abnormality of the renal collecting system (HP:0004742)3.47215272
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.45187342
11Azoospermia (HP:0000027)3.43376668
12Meckel diverticulum (HP:0002245)3.43009789
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.34961911
14Abnormality of the ileum (HP:0001549)3.29908145
15Tubulointerstitial nephritis (HP:0001970)3.29873846
16Large for gestational age (HP:0001520)3.23490135
17Hepatic necrosis (HP:0002605)3.22320152
18Increased serum pyruvate (HP:0003542)3.20875687
19Abnormality of the preputium (HP:0100587)3.12641241
20Rectal prolapse (HP:0002035)3.06971662
21Hypoplastic labia majora (HP:0000059)3.06750683
22Hypokinesia (HP:0002375)3.04720487
23Abnormality of chloride homeostasis (HP:0011422)3.03056591
24Exocrine pancreatic insufficiency (HP:0001738)3.02659720
25Pancreatic cysts (HP:0001737)2.84694638
26Abnormality of the labia majora (HP:0012881)2.76926663
27Increased hepatocellular lipid droplets (HP:0006565)2.75906023
28Clubbing of toes (HP:0100760)2.74698108
29Birth length less than 3rd percentile (HP:0003561)2.70221489
30Increased CSF lactate (HP:0002490)2.67418588
31Abnormality of glycolysis (HP:0004366)2.66071895
32Abnormality of cochlea (HP:0000375)2.65459656
33Acute encephalopathy (HP:0006846)2.59951289
34Mitochondrial inheritance (HP:0001427)2.59623046
35Abnormal pancreas size (HP:0012094)2.58380209
36Lipid accumulation in hepatocytes (HP:0006561)2.57799969
37Abnormality of the labia minora (HP:0012880)2.53342158
38Volvulus (HP:0002580)2.48895521
39Acute necrotizing encephalopathy (HP:0006965)2.48471014
40Abnormal spermatogenesis (HP:0008669)2.48262196
41Colon cancer (HP:0003003)2.45788669
42Cortical visual impairment (HP:0100704)2.42237977
43Spontaneous abortion (HP:0005268)2.42114987
44Abnormality of alanine metabolism (HP:0010916)2.40600331
45Hyperalaninemia (HP:0003348)2.40600331
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.40600331
47Abnormality of the renal cortex (HP:0011035)2.38552754
48Small intestinal stenosis (HP:0012848)2.38095590
49Duodenal stenosis (HP:0100867)2.38095590
50Absent septum pellucidum (HP:0001331)2.27915729
51Stenosis of the external auditory canal (HP:0000402)2.25212604
52Medial flaring of the eyebrow (HP:0010747)2.23737646
53Increased serum lactate (HP:0002151)2.22596396
54Renal Fanconi syndrome (HP:0001994)2.21749130
55Postnatal microcephaly (HP:0005484)2.17450643
56Abnormal mitochondria in muscle tissue (HP:0008316)2.17332059
57Follicular hyperkeratosis (HP:0007502)2.15947356
58Abnormality of the carotid arteries (HP:0005344)2.15771783
59Abnormality of renal resorption (HP:0011038)2.15176772
60CNS demyelination (HP:0007305)2.14717826
61Widely spaced teeth (HP:0000687)2.12074162
62Methylmalonic aciduria (HP:0012120)2.10228816
63Chronic hepatic failure (HP:0100626)2.05749343
64Small hand (HP:0200055)2.05489208
65Generalized myoclonic seizures (HP:0002123)2.03446728
66Abnormality of the right ventricle (HP:0001707)2.03025694
67Embryonal renal neoplasm (HP:0011794)2.01486810
68Progressive macrocephaly (HP:0004481)2.00649134
69Abnormal biliary tract morphology (HP:0012440)1.98371871
70Myelodysplasia (HP:0002863)1.94203950
71Cerebellar dysplasia (HP:0007033)1.91745096
72Abnormality of the duodenum (HP:0002246)1.91255480
73Methylmalonic acidemia (HP:0002912)1.91176043
74Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89160049
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89160049
76Exertional dyspnea (HP:0002875)1.88630009
77Neoplasm of the adrenal cortex (HP:0100641)1.88436546
78Ureteral duplication (HP:0000073)1.87917801
79Gonadal dysgenesis (HP:0000133)1.87057028
80Cerebral edema (HP:0002181)1.86043444
81Delayed CNS myelination (HP:0002188)1.84192520
82Enlarged kidneys (HP:0000105)1.83957397
83Nephroblastoma (Wilms tumor) (HP:0002667)1.83576483
84Blepharitis (HP:0000498)1.83153426
85Respiratory failure (HP:0002878)1.83150394
86Molar tooth sign on MRI (HP:0002419)1.81678482
87Abnormality of midbrain morphology (HP:0002418)1.81678482
88Morphological abnormality of the inner ear (HP:0011390)1.81261940
89Abnormality of the dental root (HP:0006486)1.79989530
90Taurodontia (HP:0000679)1.79989530
91Abnormality of permanent molar morphology (HP:0011071)1.79989530
92Cystic liver disease (HP:0006706)1.79786083
93Poor coordination (HP:0002370)1.79042984
94Absent eyebrow (HP:0002223)1.78336455
95Abnormality of the septum pellucidum (HP:0007375)1.76090161
96Type II lissencephaly (HP:0007260)1.74418545
97Congenital primary aphakia (HP:0007707)1.74370591
98Bifid tongue (HP:0010297)1.73100899
99Tubulointerstitial abnormality (HP:0001969)1.70027993
100Choanal atresia (HP:0000453)1.69527149

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK28.40227270
2MAP4K24.74433730
3EIF2AK33.59564731
4BRSK22.99039557
5MST42.98296119
6TNIK2.47558863
7VRK22.25565046
8ZAK2.13885459
9TAF12.02288129
10TAOK32.00585452
11FRK1.95988513
12PLK41.93399813
13PRKG21.90680017
14AKT31.66985684
15NUAK11.64985147
16PASK1.63738677
17BUB11.63245002
18CDC71.60369033
19PLK31.57850978
20STK31.55894893
21TTK1.54475712
22WEE11.53416607
23ACVR1B1.52270754
24NEK11.51756560
25PBK1.50123372
26MKNK21.25874562
27CCNB11.23148916
28PDK21.15432278
29PAK31.14626679
30STK241.10610267
31TRIM281.09007014
32FGFR21.01172520
33NME10.98882995
34BRSK10.97942532
35WNK30.93643083
36CDK30.90357887
37NLK0.87771219
38BRD40.87439548
39EIF2AK20.80653071
40STK38L0.78097876
41PLK10.76551018
42ATM0.75507024
43CLK10.74575910
44ERBB30.72565635
45FER0.70586819
46PRKCI0.69916598
47PRKAA10.69856375
48VRK10.69560788
49ATR0.68767470
50BCKDK0.67288453
51DAPK10.67046810
52WNK40.65200335
53MAP3K30.64972255
54OXSR10.63529686
55MKNK10.63376074
56BMPR1B0.61533495
57BCR0.59846417
58ADRBK20.59000566
59PLK20.55164690
60PRKCE0.54146242
61MELK0.52088393
62MAP3K120.48602333
63PRKAA20.47724246
64DAPK20.47195988
65TSSK60.46817625
66MAP3K20.44468849
67PNCK0.43900662
68EPHA40.40915763
69ERBB20.39934084
70STK100.39803006
71AURKB0.39135856
72PRKG10.38767990
73PRKDC0.38200210
74SGK20.38019901
75MAPK130.37516015
76TNK20.37340122
77SRPK10.37325760
78EPHB20.37258328
79CAMKK20.36455296
80TGFBR10.34354283
81CHEK20.33694680
82INSRR0.32893397
83DAPK30.31542855
84PAK10.30819694
85CSNK2A10.30604382
86STK40.29703780
87CSNK1D0.29434872
88ROCK10.29380796
89SIK30.28741385
90CDK70.27216409
91STK110.27185102
92CSNK1A10.25983943
93CHEK10.25161697
94EIF2AK10.24032405
95NEK60.22932368
96LATS10.20763193
97GRK10.20616527
98CAMK1G0.19870220
99NEK20.19805557
100FGFR10.19504242

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.77907388
2Mismatch repair_Homo sapiens_hsa034303.57059915
3DNA replication_Homo sapiens_hsa030302.82770892
4Steroid biosynthesis_Homo sapiens_hsa001002.80426422
5Fanconi anemia pathway_Homo sapiens_hsa034602.77861217
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.67320649
7Non-homologous end-joining_Homo sapiens_hsa034502.52309099
8Caffeine metabolism_Homo sapiens_hsa002322.51800223
9Proteasome_Homo sapiens_hsa030502.50251970
10Propanoate metabolism_Homo sapiens_hsa006402.17566813
11Vitamin digestion and absorption_Homo sapiens_hsa049772.11156288
12Vitamin B6 metabolism_Homo sapiens_hsa007502.07459467
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05690945
14Nucleotide excision repair_Homo sapiens_hsa034202.05486203
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98973270
16Oxidative phosphorylation_Homo sapiens_hsa001901.89995908
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85815220
18Protein export_Homo sapiens_hsa030601.82327026
19One carbon pool by folate_Homo sapiens_hsa006701.80107909
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79698234
21RNA polymerase_Homo sapiens_hsa030201.75181687
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.74559376
23Basal transcription factors_Homo sapiens_hsa030221.71642669
24Selenocompound metabolism_Homo sapiens_hsa004501.65959577
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52006945
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48438584
27RNA transport_Homo sapiens_hsa030131.46993928
28Parkinsons disease_Homo sapiens_hsa050121.33755899
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.33282337
30Cell cycle_Homo sapiens_hsa041101.31152150
31Glutathione metabolism_Homo sapiens_hsa004801.29771248
32Sulfur metabolism_Homo sapiens_hsa009201.23434770
33Butanoate metabolism_Homo sapiens_hsa006501.21808710
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19866290
35Nitrogen metabolism_Homo sapiens_hsa009101.17958840
36Retinol metabolism_Homo sapiens_hsa008301.15343249
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11608980
38Linoleic acid metabolism_Homo sapiens_hsa005911.10825713
39Huntingtons disease_Homo sapiens_hsa050161.08093051
40Fat digestion and absorption_Homo sapiens_hsa049751.05897665
41Pyrimidine metabolism_Homo sapiens_hsa002401.05599362
42Fatty acid elongation_Homo sapiens_hsa000621.04081740
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98762729
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97664303
45RNA degradation_Homo sapiens_hsa030180.97074800
46Chemical carcinogenesis_Homo sapiens_hsa052040.95333543
47Purine metabolism_Homo sapiens_hsa002300.92965617
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.92027551
49mRNA surveillance pathway_Homo sapiens_hsa030150.91695012
50p53 signaling pathway_Homo sapiens_hsa041150.87350627
51Alzheimers disease_Homo sapiens_hsa050100.80529484
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79714287
53Base excision repair_Homo sapiens_hsa034100.79222906
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.78230096
55Fructose and mannose metabolism_Homo sapiens_hsa000510.76261689
56Systemic lupus erythematosus_Homo sapiens_hsa053220.75028952
57Ether lipid metabolism_Homo sapiens_hsa005650.73533544
58Tryptophan metabolism_Homo sapiens_hsa003800.73033889
59ABC transporters_Homo sapiens_hsa020100.72893491
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68797885
61Spliceosome_Homo sapiens_hsa030400.67115884
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65923984
63beta-Alanine metabolism_Homo sapiens_hsa004100.65611218
64Peroxisome_Homo sapiens_hsa041460.65569535
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.63961070
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.62925540
67Complement and coagulation cascades_Homo sapiens_hsa046100.61845253
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60957120
69Bile secretion_Homo sapiens_hsa049760.60524828
70Oocyte meiosis_Homo sapiens_hsa041140.59911623
71Metabolic pathways_Homo sapiens_hsa011000.59066387
72Phototransduction_Homo sapiens_hsa047440.58951010
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58580106
74Circadian rhythm_Homo sapiens_hsa047100.57810845
75Arginine and proline metabolism_Homo sapiens_hsa003300.57642459
76Alcoholism_Homo sapiens_hsa050340.56389767
77Pyruvate metabolism_Homo sapiens_hsa006200.55908176
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53494778
79Olfactory transduction_Homo sapiens_hsa047400.51736368
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50953581
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48541163
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46972231
83Arginine biosynthesis_Homo sapiens_hsa002200.44688227
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40257306
85Pancreatic secretion_Homo sapiens_hsa049720.38140815
86Lysine degradation_Homo sapiens_hsa003100.35930579
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.34371670
88Sphingolipid metabolism_Homo sapiens_hsa006000.33742678
89Hedgehog signaling pathway_Homo sapiens_hsa043400.33614696
90Cardiac muscle contraction_Homo sapiens_hsa042600.33427254
91Collecting duct acid secretion_Homo sapiens_hsa049660.32745973
92Thyroid hormone synthesis_Homo sapiens_hsa049180.32569572
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31450238
94Biosynthesis of amino acids_Homo sapiens_hsa012300.29361826
95Nicotine addiction_Homo sapiens_hsa050330.27993384
96Tight junction_Homo sapiens_hsa045300.26762670
97Carbon metabolism_Homo sapiens_hsa012000.25835708
98African trypanosomiasis_Homo sapiens_hsa051430.25141805
99N-Glycan biosynthesis_Homo sapiens_hsa005100.24729275
100Gastric acid secretion_Homo sapiens_hsa049710.24412324

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