MTND4P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.95853554
2locomotory exploration behavior (GO:0035641)7.45762443
3presynaptic membrane organization (GO:0097090)6.54009338
4neuron cell-cell adhesion (GO:0007158)6.45815057
5positive regulation of amino acid transport (GO:0051957)6.15936506
6nucleobase catabolic process (GO:0046113)6.10344737
7regulation of neuron projection regeneration (GO:0070570)5.84084556
8regulation of axon regeneration (GO:0048679)5.84084556
9presynaptic membrane assembly (GO:0097105)5.79848221
10cerebral cortex radially oriented cell migration (GO:0021799)5.71063843
11lysine metabolic process (GO:0006553)4.94678147
12lysine catabolic process (GO:0006554)4.94678147
13maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.93919685
14regulation of transmission of nerve impulse (GO:0051969)4.92492823
15C4-dicarboxylate transport (GO:0015740)4.78679296
16exploration behavior (GO:0035640)4.63291443
17positive regulation of neurological system process (GO:0031646)4.55057521
18replication fork processing (GO:0031297)4.54289647
19resolution of meiotic recombination intermediates (GO:0000712)4.49422876
20blood vessel maturation (GO:0001955)4.49280653
21histone H3-K9 methylation (GO:0051567)4.43235734
22positive regulation of developmental pigmentation (GO:0048087)4.41454682
23regulation of pigment cell differentiation (GO:0050932)4.38884909
24postsynaptic membrane organization (GO:0001941)4.32696609
25translesion synthesis (GO:0019985)4.16562403
26auditory behavior (GO:0031223)4.11997063
27mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.05322475
28positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.05322475
29microtubule depolymerization (GO:0007019)3.96673346
30central nervous system projection neuron axonogenesis (GO:0021952)3.93126373
31positive regulation of dendritic spine morphogenesis (GO:0061003)3.89482858
32histone H3-K9 modification (GO:0061647)3.81130037
33regulation of glutamate secretion (GO:0014048)3.79886808
34aspartate family amino acid catabolic process (GO:0009068)3.79877697
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.78881428
36meiotic chromosome segregation (GO:0045132)3.76425377
37spinal cord development (GO:0021510)3.64708359
38olfactory bulb development (GO:0021772)3.58759497
39negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.57389117
40protein neddylation (GO:0045116)3.56287190
41cell migration in hindbrain (GO:0021535)3.48770872
42negative regulation of axon extension (GO:0030517)3.46030624
43L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.45827447
44polyol transport (GO:0015791)3.39919675
45microtubule nucleation (GO:0007020)3.37115586
46DNA topological change (GO:0006265)3.36095375
47protein localization to synapse (GO:0035418)3.35686082
48water-soluble vitamin biosynthetic process (GO:0042364)3.33351607
49mechanosensory behavior (GO:0007638)3.31549425
50gamma-aminobutyric acid transport (GO:0015812)3.25506700
51DNA double-strand break processing (GO:0000729)3.24692088
52telencephalon cell migration (GO:0022029)3.22382929
53negative regulation of astrocyte differentiation (GO:0048712)3.20751258
54establishment of protein localization to Golgi (GO:0072600)3.19645597
55regulation of amino acid transport (GO:0051955)3.19057523
56negative regulation of translation, ncRNA-mediated (GO:0040033)3.17113387
57regulation of translation, ncRNA-mediated (GO:0045974)3.17113387
58negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.17113387
59postreplication repair (GO:0006301)3.15402806
60forebrain cell migration (GO:0021885)3.14790998
61positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.05881221
62cerebral cortex cell migration (GO:0021795)3.05077248
63glycosphingolipid biosynthetic process (GO:0006688)3.04669838
64microtubule anchoring (GO:0034453)3.02777510
65protein targeting to Golgi (GO:0000042)3.00256161
66establishment of spindle localization (GO:0051293)2.98247311
67somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96538845
68somatic hypermutation of immunoglobulin genes (GO:0016446)2.96538845
69spinal cord motor neuron differentiation (GO:0021522)2.95948930
70central nervous system neuron axonogenesis (GO:0021955)2.89857342
71mitotic sister chromatid segregation (GO:0000070)2.88154418
72retrograde transport, vesicle recycling within Golgi (GO:0000301)2.85962870
73auditory receptor cell stereocilium organization (GO:0060088)2.85808270
74protein K11-linked deubiquitination (GO:0035871)2.84778467
75negative regulation of glial cell differentiation (GO:0045686)2.84720624
76calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.84542473
77ovulation cycle (GO:0042698)2.84386772
78sister chromatid segregation (GO:0000819)2.83032953
79L-methionine salvage (GO:0071267)2.82906492
80L-methionine biosynthetic process (GO:0071265)2.82906492
81amino acid salvage (GO:0043102)2.82906492
82acrosome assembly (GO:0001675)2.82087510
83negative regulation of execution phase of apoptosis (GO:1900118)2.77634461
84transepithelial transport (GO:0070633)2.76613471
85neurotransmitter-gated ion channel clustering (GO:0072578)2.76197182
86startle response (GO:0001964)2.75657695
87dendrite morphogenesis (GO:0048813)2.74462749
88negative regulation of DNA-dependent DNA replication (GO:2000104)2.72906744
89protein polyglutamylation (GO:0018095)2.72361637
90positive regulation of synapse assembly (GO:0051965)2.69650437
91aspartate family amino acid biosynthetic process (GO:0009067)2.69586848
92positive regulation of organic acid transport (GO:0032892)2.69332771
93inner ear receptor stereocilium organization (GO:0060122)2.68754437
94response to cocaine (GO:0042220)2.65860701
95regulation of synapse maturation (GO:0090128)2.65704990
96regulation of Rac GTPase activity (GO:0032314)2.60674742
97protein localization to Golgi apparatus (GO:0034067)2.59800733
98ionotropic glutamate receptor signaling pathway (GO:0035235)2.59735247
99import into cell (GO:0098657)2.58591846
100telencephalon development (GO:0021537)2.58117053

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.84252464
2ZNF274_21170338_ChIP-Seq_K562_Hela3.43220917
3GBX2_23144817_ChIP-Seq_PC3_Human3.41246539
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.90354929
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.86347172
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.65790575
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.60698928
8AR_21572438_ChIP-Seq_LNCaP_Human2.60468402
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.48882160
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.47830238
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.47704030
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.46616085
13EZH2_22144423_ChIP-Seq_EOC_Human2.37201268
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.27909977
15PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.23577014
16VDR_22108803_ChIP-Seq_LS180_Human2.20027319
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19199085
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.15781074
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08667745
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06345104
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.00692756
22FUS_26573619_Chip-Seq_HEK293_Human1.98592852
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.98342598
24EWS_26573619_Chip-Seq_HEK293_Human1.96360747
25OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95222392
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94881369
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88891422
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88406919
29TAF15_26573619_Chip-Seq_HEK293_Human1.86988631
30P300_19829295_ChIP-Seq_ESCs_Human1.85897720
31SMAD4_21799915_ChIP-Seq_A2780_Human1.85361262
32ER_23166858_ChIP-Seq_MCF-7_Human1.83656317
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82968082
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.81912213
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77524701
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66465201
37TCF4_23295773_ChIP-Seq_U87_Human1.66412972
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61615842
39CBP_20019798_ChIP-Seq_JUKART_Human1.61615842
40IGF1R_20145208_ChIP-Seq_DFB_Human1.61030091
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60609726
42STAT3_23295773_ChIP-Seq_U87_Human1.57458943
43RNF2_27304074_Chip-Seq_NSC_Mouse1.54071313
44CIITA_25753668_ChIP-Seq_RAJI_Human1.53185225
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.52850181
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.52128879
47SOX9_26525672_Chip-Seq_HEART_Mouse1.48507526
48CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46704038
49ELK1_19687146_ChIP-ChIP_HELA_Human1.45246786
50REST_21632747_ChIP-Seq_MESCs_Mouse1.44492831
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43256369
52BCAT_22108803_ChIP-Seq_LS180_Human1.42316614
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.40469380
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37792923
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37297193
56TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33908365
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29315612
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.24716703
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24618916
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23948174
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23855843
62TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.23780512
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.23682365
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23257559
65JUN_21703547_ChIP-Seq_K562_Human1.22821834
66AR_25329375_ChIP-Seq_VCAP_Human1.22383755
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21819979
68RUNX2_22187159_ChIP-Seq_PCA_Human1.21348973
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.20485146
70HTT_18923047_ChIP-ChIP_STHdh_Human1.18102732
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.17658333
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13722575
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13108997
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13108997
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11461844
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09385583
77IRF1_19129219_ChIP-ChIP_H3396_Human1.08549513
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07549375
79VDR_23849224_ChIP-Seq_CD4+_Human1.07149879
80TCF4_22108803_ChIP-Seq_LS180_Human1.06661820
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05501263
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04725837
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.04613902
84KDM2B_26808549_Chip-Seq_REH_Human1.03159887
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.02963601
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01957220
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99979959
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99596137
89TAL1_26923725_Chip-Seq_HPCs_Mouse0.99515805
90SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99269478
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99025467
92CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98521236
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97557539
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97334335
95POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.96947854
96PRDM14_20953172_ChIP-Seq_ESCs_Human0.96937004
97P53_22387025_ChIP-Seq_ESCs_Mouse0.95758160
98TP53_18474530_ChIP-ChIP_U2OS_Human0.91885735
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.91799643
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90394501

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia3.74811289
2MP0003646_muscle_fatigue3.45396439
3MP0002736_abnormal_nociception_after3.16183173
4MP0005360_urolithiasis3.13386811
5MP0004859_abnormal_synaptic_plasticity3.10751944
6MP0001968_abnormal_touch/_nociception3.01309535
7MP0001986_abnormal_taste_sensitivity2.98691350
8MP0003136_yellow_coat_color2.69719867
9MP0004885_abnormal_endolymph2.63738518
10MP0009046_muscle_twitch2.63713212
11MP0002735_abnormal_chemical_nociception2.22827351
12MP0004782_abnormal_surfactant_physiolog2.19409765
13MP0005083_abnormal_biliary_tract2.16148081
14MP0000631_abnormal_neuroendocrine_gland2.09584318
15MP0001486_abnormal_startle_reflex2.01507209
16MP0000569_abnormal_digit_pigmentation1.96843006
17MP0006292_abnormal_olfactory_placode1.94414849
18MP0004924_abnormal_behavior1.80699335
19MP0005386_behavior/neurological_phenoty1.80699335
20MP0002751_abnormal_autonomic_nervous1.79281708
21MP0005551_abnormal_eye_electrophysiolog1.75963928
22MP0001919_abnormal_reproductive_system1.70502768
23MP0000778_abnormal_nervous_system1.70375729
24MP0004133_heterotaxia1.69097839
25MP0003635_abnormal_synaptic_transmissio1.68717574
26MP0002063_abnormal_learning/memory/cond1.67956094
27MP0002938_white_spotting1.61981835
28MP0008058_abnormal_DNA_repair1.60154529
29MP0002272_abnormal_nervous_system1.59009017
30MP0000372_irregular_coat_pigmentation1.52786962
31MP0003880_abnormal_central_pattern1.50964828
32MP0008569_lethality_at_weaning1.49544888
33MP0002557_abnormal_social/conspecific_i1.46005079
34MP0002064_seizures1.45208086
35MP0002067_abnormal_sensory_capabilities1.42270838
36MP0004142_abnormal_muscle_tone1.40556626
37MP0001485_abnormal_pinna_reflex1.38781492
38MP0000516_abnormal_urinary_system1.38270998
39MP0005367_renal/urinary_system_phenotyp1.38270998
40MP0002837_dystrophic_cardiac_calcinosis1.37941118
41MP0001984_abnormal_olfaction1.33304963
42MP0001440_abnormal_grooming_behavior1.31458844
43MP0002572_abnormal_emotion/affect_behav1.29321685
44MP0009745_abnormal_behavioral_response1.28454529
45MP0001764_abnormal_homeostasis1.28422575
46MP0002928_abnormal_bile_duct1.26893955
47MP0004742_abnormal_vestibular_system1.26715777
48MP0008877_abnormal_DNA_methylation1.26692709
49MP0003632_abnormal_nervous_system1.26333763
50MP0004811_abnormal_neuron_physiology1.26084694
51MP0008872_abnormal_physiological_respon1.23364132
52MP0003718_maternal_effect1.20723616
53MP0002752_abnormal_somatic_nervous1.16748627
54MP0002152_abnormal_brain_morphology1.15662540
55MP0000383_abnormal_hair_follicle1.14758458
56MP0005075_abnormal_melanosome_morpholog1.14562088
57MP0003943_abnormal_hepatobiliary_system1.13651574
58MP0002882_abnormal_neuron_morphology1.11018765
59MP0000049_abnormal_middle_ear1.09905427
60MP0005171_absent_coat_pigmentation1.07429230
61MP0002734_abnormal_mechanical_nocicepti1.06537695
62MP0005389_reproductive_system_phenotype1.05812943
63MP0002229_neurodegeneration1.05281157
64MP0002282_abnormal_trachea_morphology1.05240095
65MP0003787_abnormal_imprinting1.01865251
66MP0005084_abnormal_gallbladder_morpholo1.01429998
67MP0004957_abnormal_blastocyst_morpholog1.01309560
68MP0003631_nervous_system_phenotype1.00552120
69MP0003861_abnormal_nervous_system0.97813123
70MP0005253_abnormal_eye_physiology0.94519273
71MP0002234_abnormal_pharynx_morphology0.93833750
72MP0008932_abnormal_embryonic_tissue0.93632719
73MP0002066_abnormal_motor_capabilities/c0.93324646
74MP0003755_abnormal_palate_morphology0.92986670
75MP0001270_distended_abdomen0.92134974
76MP0004381_abnormal_hair_follicle0.89122471
77MP0005645_abnormal_hypothalamus_physiol0.86892560
78MP0000920_abnormal_myelination0.85635792
79MP0005410_abnormal_fertilization0.85570486
80MP0001324_abnormal_eye_pigmentation0.85211368
81MP0005408_hypopigmentation0.84867106
82MP0005195_abnormal_posterior_eye0.84771883
83MP0002102_abnormal_ear_morphology0.83939629
84MP0003111_abnormal_nucleus_morphology0.83882890
85MP0000026_abnormal_inner_ear0.79739941
86MP0003693_abnormal_embryo_hatching0.79626376
87MP0001929_abnormal_gametogenesis0.78648775
88MP0005187_abnormal_penis_morphology0.76834051
89MP0002653_abnormal_ependyma_morphology0.72242394
90MP0003077_abnormal_cell_cycle0.72127491
91MP0003698_abnormal_male_reproductive0.71589186
92MP0010678_abnormal_skin_adnexa0.71480476
93MP0001191_abnormal_skin_condition0.70948234
94MP0001963_abnormal_hearing_physiology0.70265245
95MP0000749_muscle_degeneration0.70232636
96MP0002733_abnormal_thermal_nociception0.70220828
97MP0002069_abnormal_eating/drinking_beha0.68953592
98MP0003633_abnormal_nervous_system0.66331740
99MP0010770_preweaning_lethality0.65668311
100MP0002082_postnatal_lethality0.65668311

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)5.62039080
2Type II lissencephaly (HP:0007260)4.76855861
3Optic nerve hypoplasia (HP:0000609)4.34307020
4Hyperventilation (HP:0002883)3.89080404
5Focal motor seizures (HP:0011153)3.84697487
6Lissencephaly (HP:0001339)3.73632628
7Aplasia/Hypoplasia of the optic nerve (HP:0008058)3.66558219
8Cerebellar dysplasia (HP:0007033)3.58599207
9Carpal bone hypoplasia (HP:0001498)3.37724806
10True hermaphroditism (HP:0010459)3.29162604
11Pancreatic cysts (HP:0001737)3.20787205
12Abnormality of the septum pellucidum (HP:0007375)3.19143245
13Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.14434901
14Retinal dysplasia (HP:0007973)3.09234332
15Absent septum pellucidum (HP:0001331)3.08387532
16Ependymoma (HP:0002888)3.03248883
17Pancreatic fibrosis (HP:0100732)3.02385873
18Disproportionate short-trunk short stature (HP:0003521)2.93541185
19Vitreoretinal degeneration (HP:0000655)2.88889497
20Nephronophthisis (HP:0000090)2.87991297
21Molar tooth sign on MRI (HP:0002419)2.83916085
22Abnormality of midbrain morphology (HP:0002418)2.83916085
23Methylmalonic acidemia (HP:0002912)2.81722815
24Small epiphyses (HP:0010585)2.79265907
25Absent speech (HP:0001344)2.78967273
26Prominent metopic ridge (HP:0005487)2.77897814
27Pachygyria (HP:0001302)2.70610934
28Aplasia/Hypoplasia of the tongue (HP:0010295)2.67442613
29Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.66680751
30Vertebral arch anomaly (HP:0008438)2.59394648
31Abnormality of the sella turcica (HP:0002679)2.58968589
32Irregular vertebral endplates (HP:0003301)2.58159004
33Abnormality of the proximal phalanges of the hand (HP:0009834)2.57965555
34Abnormality of the metopic suture (HP:0005556)2.57264396
35Medial flaring of the eyebrow (HP:0010747)2.54970565
36Occipital encephalocele (HP:0002085)2.49371596
37Growth hormone deficiency (HP:0000824)2.41568557
38Flat capital femoral epiphysis (HP:0003370)2.39431476
39Abnormality of the vertebral endplates (HP:0005106)2.39017643
40Gait imbalance (HP:0002141)2.35980690
41Abnormality of DNA repair (HP:0003254)2.35525845
42Congenital primary aphakia (HP:0007707)2.33740968
43Abnormality of the renal medulla (HP:0100957)2.31957384
44Stomach cancer (HP:0012126)2.28582961
45Astrocytoma (HP:0009592)2.27338096
46Abnormality of the astrocytes (HP:0100707)2.27338096
47Bile duct proliferation (HP:0001408)2.27157391
48Abnormal biliary tract physiology (HP:0012439)2.27157391
49Protruding tongue (HP:0010808)2.25283485
50Pendular nystagmus (HP:0012043)2.22560491
51Irregular epiphyses (HP:0010582)2.22355333
52Abnormality of the vitamin B12 metabolism (HP:0004341)2.19584910
53Hypsarrhythmia (HP:0002521)2.16971914
54Fibular aplasia (HP:0002990)2.16598574
55Broad-based gait (HP:0002136)2.15504589
56Focal seizures (HP:0007359)2.14140986
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.12204415
58Meckel diverticulum (HP:0002245)2.11075902
59Anterior segment dysgenesis (HP:0007700)2.10404494
60Increased corneal curvature (HP:0100692)2.09480744
61Keratoconus (HP:0000563)2.09480744
62Cortical dysplasia (HP:0002539)2.06839382
63Epileptiform EEG discharges (HP:0011182)2.05161096
64Narrow forehead (HP:0000341)2.04918185
65EEG with generalized epileptiform discharges (HP:0011198)2.03784439
66Abnormality of the ileum (HP:0001549)2.02763891
67Aplasia/Hypoplasia of the tibia (HP:0005772)2.00165428
68Astigmatism (HP:0000483)1.98331929
69Cystic liver disease (HP:0006706)1.97612763
70Intellectual disability, severe (HP:0010864)1.97404804
71Broad foot (HP:0001769)1.95535652
72Polymicrogyria (HP:0002126)1.95237612
73Short tibia (HP:0005736)1.94991872
74Abnormality of vitamin B metabolism (HP:0004340)1.94654186
75Nephrogenic diabetes insipidus (HP:0009806)1.94123933
76Biconcave vertebral bodies (HP:0004586)1.93910171
77Postaxial foot polydactyly (HP:0001830)1.93670714
78Broad distal phalanx of finger (HP:0009836)1.93627968
79Hypoplasia of the brainstem (HP:0002365)1.92861625
80Aplasia/Hypoplasia of the brainstem (HP:0007362)1.92861625
81Abnormality of the preputium (HP:0100587)1.91547327
82Meningocele (HP:0002435)1.90690139
83Hypoplasia of the capital femoral epiphysis (HP:0003090)1.90236389
84Congenital stationary night blindness (HP:0007642)1.89068174
85Flattened epiphyses (HP:0003071)1.88261752
86Large earlobe (HP:0009748)1.88109866
87Epileptic encephalopathy (HP:0200134)1.87891627
88Postaxial hand polydactyly (HP:0001162)1.84509046
89Hyperglycinemia (HP:0002154)1.83654764
90Widely spaced teeth (HP:0000687)1.83494061
91Abnormality of chromosome stability (HP:0003220)1.83421395
92Oculomotor apraxia (HP:0000657)1.81799215
93Sclerocornea (HP:0000647)1.81507013
94Tented upper lip vermilion (HP:0010804)1.81083512
95Drooling (HP:0002307)1.80722692
96Renal cortical cysts (HP:0000803)1.77692155
97Dandy-Walker malformation (HP:0001305)1.76515075
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76431302
99Methylmalonic aciduria (HP:0012120)1.75782086
100Bifid tongue (HP:0010297)1.75357027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K27.15114583
2IRAK24.95150003
3CASK4.57596401
4IRAK13.86080967
5MARK13.76100668
6MAPK133.04656313
7TNIK2.59113418
8YES12.57183928
9DYRK22.31595729
10BRSK22.13303548
11CCNB12.10905395
12BCKDK2.07557900
13NEK12.06400224
14BMPR1B1.91321958
15RPS6KB21.69944853
16WNK31.42608581
17TRIM281.34389380
18MARK31.28097089
19SIK31.25440290
20MAP2K71.23779912
21ERBB41.18201662
22UHMK11.17763313
23BRSK11.16627831
24MKNK21.13343966
25NUAK11.09572705
26NEK20.98268317
27CSNK1G10.97962103
28FRK0.97173192
29NTRK30.97151468
30MKNK10.96379273
31PRKD30.93275991
32STK30.92664317
33ERBB30.92501204
34CSNK1A1L0.89755012
35VRK10.89249517
36MAP3K40.86783863
37PLK30.86172232
38EIF2AK30.82083589
39PNCK0.78863795
40TGFBR10.77346266
41PKN10.76222716
42WEE10.73768285
43CLK10.72645516
44CSNK1G30.72328858
45NTRK20.70383738
46EPHB20.69212554
47CDC70.67298123
48INSRR0.63827828
49ATM0.63635510
50CDK30.63559640
51CDK50.61865042
52TTK0.60431121
53CSNK1G20.59375962
54ADRBK20.55814105
55SGK20.52854722
56RPS6KB10.52509750
57PRKCG0.52117980
58DMPK0.50599070
59ROCK20.50185520
60EPHA40.49921450
61AKT30.48819766
62GSK3A0.45616553
63EIF2AK20.45472787
64CHEK10.44481753
65CHEK20.43983356
66BRAF0.43418355
67PLK10.41307969
68CDK180.41066914
69CSNK1A10.39333373
70ROCK10.38180771
71MAPK90.37808812
72ABL10.37247544
73CDK150.37240924
74MAPK80.36937147
75ARAF0.36568969
76CDK11A0.35800495
77MAPKAPK30.33989969
78SGK2230.33831924
79SGK4940.33831924
80TIE10.31760062
81TEC0.31166649
82MAP3K90.30814626
83MAPKAPK50.30656741
84PRKACA0.30593356
85PRKCE0.30558568
86SGK10.30353559
87IGF1R0.29678509
88SGK30.29258275
89SRPK10.29128062
90ERBB20.28911668
91NME10.28539885
92MAPK150.27381749
93RAF10.26752668
94LYN0.24727332
95GSK3B0.24590610
96CDK10.24167622
97PRKCZ0.23698080
98PRKDC0.22937302
99ACVR1B0.22297099
100PRKCB0.22200664

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.51667282
2Non-homologous end-joining_Homo sapiens_hsa034504.05280066
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.02813343
4Base excision repair_Homo sapiens_hsa034102.60668353
5Lysine degradation_Homo sapiens_hsa003102.54493095
6Fanconi anemia pathway_Homo sapiens_hsa034602.50103945
7Homologous recombination_Homo sapiens_hsa034402.48113689
8Basal transcription factors_Homo sapiens_hsa030222.38219022
9Phototransduction_Homo sapiens_hsa047442.32084216
10Nicotine addiction_Homo sapiens_hsa050332.29329260
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.24986636
12Ether lipid metabolism_Homo sapiens_hsa005652.14203244
13Butanoate metabolism_Homo sapiens_hsa006502.11403538
14Steroid biosynthesis_Homo sapiens_hsa001002.00971107
15mRNA surveillance pathway_Homo sapiens_hsa030151.84249462
16Olfactory transduction_Homo sapiens_hsa047401.66789138
17Cocaine addiction_Homo sapiens_hsa050301.63086525
18Regulation of autophagy_Homo sapiens_hsa041401.61613434
19Glutamatergic synapse_Homo sapiens_hsa047241.55346426
20Dopaminergic synapse_Homo sapiens_hsa047281.50494916
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46635808
22Propanoate metabolism_Homo sapiens_hsa006401.45003564
23Long-term depression_Homo sapiens_hsa047301.36484272
24Linoleic acid metabolism_Homo sapiens_hsa005911.34877172
25GABAergic synapse_Homo sapiens_hsa047271.33630633
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26820784
27Amphetamine addiction_Homo sapiens_hsa050311.24287184
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.24063448
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23191676
30Oocyte meiosis_Homo sapiens_hsa041141.21108683
31Protein export_Homo sapiens_hsa030601.19495951
32Nucleotide excision repair_Homo sapiens_hsa034201.19176286
33Tryptophan metabolism_Homo sapiens_hsa003801.16767596
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12244311
35Salivary secretion_Homo sapiens_hsa049701.10340711
36Spliceosome_Homo sapiens_hsa030401.09778702
37RNA degradation_Homo sapiens_hsa030181.08156711
38RNA polymerase_Homo sapiens_hsa030201.05796327
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01667265
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99656174
41Circadian entrainment_Homo sapiens_hsa047130.97700517
42Dorso-ventral axis formation_Homo sapiens_hsa043200.97374598
43Morphine addiction_Homo sapiens_hsa050320.94412670
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93580357
45Inositol phosphate metabolism_Homo sapiens_hsa005620.93214549
46Mismatch repair_Homo sapiens_hsa034300.92689694
47Taste transduction_Homo sapiens_hsa047420.89738262
48Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85962042
49RNA transport_Homo sapiens_hsa030130.81102885
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79145837
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78146067
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77510202
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74515539
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73361236
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71423637
56Sphingolipid metabolism_Homo sapiens_hsa006000.70795704
57Insulin secretion_Homo sapiens_hsa049110.70526707
58Serotonergic synapse_Homo sapiens_hsa047260.68001246
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67212616
60Histidine metabolism_Homo sapiens_hsa003400.66417480
61Nitrogen metabolism_Homo sapiens_hsa009100.66177308
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63751253
63beta-Alanine metabolism_Homo sapiens_hsa004100.62287681
64Axon guidance_Homo sapiens_hsa043600.61946044
65Cholinergic synapse_Homo sapiens_hsa047250.61748366
66Primary immunodeficiency_Homo sapiens_hsa053400.58878294
67Long-term potentiation_Homo sapiens_hsa047200.58334423
68Hippo signaling pathway_Homo sapiens_hsa043900.55529607
69Sulfur relay system_Homo sapiens_hsa041220.53963568
70AMPK signaling pathway_Homo sapiens_hsa041520.51614373
71Glycerolipid metabolism_Homo sapiens_hsa005610.51229558
72Choline metabolism in cancer_Homo sapiens_hsa052310.49349665
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49286718
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49180163
75Fatty acid metabolism_Homo sapiens_hsa012120.48232504
76Oxidative phosphorylation_Homo sapiens_hsa001900.46889580
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44620857
78Ovarian steroidogenesis_Homo sapiens_hsa049130.43894964
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41536685
80cAMP signaling pathway_Homo sapiens_hsa040240.41366831
81Sulfur metabolism_Homo sapiens_hsa009200.41255344
82Proteasome_Homo sapiens_hsa030500.39120277
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38014982
84Calcium signaling pathway_Homo sapiens_hsa040200.37263752
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.36731627
86Caffeine metabolism_Homo sapiens_hsa002320.33686852
87Huntingtons disease_Homo sapiens_hsa050160.31162192
88TGF-beta signaling pathway_Homo sapiens_hsa043500.30606895
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29962119
90Alcoholism_Homo sapiens_hsa050340.28126657
91Hedgehog signaling pathway_Homo sapiens_hsa043400.27327667
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22448393
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22325016
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21183529
95MicroRNAs in cancer_Homo sapiens_hsa052060.20590844
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18637551
97Mineral absorption_Homo sapiens_hsa049780.18462066
98Estrogen signaling pathway_Homo sapiens_hsa049150.17735332
99Chemical carcinogenesis_Homo sapiens_hsa052040.16003171
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15950048

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