MTND5P10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle adaptation (GO:0043501)8.86877550
2striated muscle atrophy (GO:0014891)8.83181901
3muscle atrophy (GO:0014889)7.84159335
4negative regulation of muscle hypertrophy (GO:0014741)6.87461797
5muscle filament sliding (GO:0030049)6.53461158
6actin-myosin filament sliding (GO:0033275)6.53461158
7negative regulation of skeletal muscle tissue development (GO:0048642)6.43819310
8regulation of skeletal muscle contraction (GO:0014819)6.41933459
9skeletal muscle tissue regeneration (GO:0043403)5.99806482
10response to muscle activity (GO:0014850)5.70579994
11actin-mediated cell contraction (GO:0070252)5.28710407
12cellular response to dexamethasone stimulus (GO:0071549)4.74139827
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.52376653
14negative regulation of cell killing (GO:0031342)4.52376653
15response to dexamethasone (GO:0071548)4.36503435
16response to activity (GO:0014823)4.35411409
17cellular response to interleukin-15 (GO:0071350)4.33137346
18protein polyglutamylation (GO:0018095)4.31815555
19protein K6-linked ubiquitination (GO:0085020)4.05535371
20sleep (GO:0030431)4.01761615
21endoderm formation (GO:0001706)3.96134536
22DNA deamination (GO:0045006)3.82511723
23behavioral response to nicotine (GO:0035095)3.80478569
24regulation of germinal center formation (GO:0002634)3.79915430
25negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.76642034
26striated muscle adaptation (GO:0014888)3.72649343
27tolerance induction (GO:0002507)3.67406836
28cytidine deamination (GO:0009972)3.60461066
29cytidine metabolic process (GO:0046087)3.60461066
30cytidine catabolic process (GO:0006216)3.60461066
31response to testosterone (GO:0033574)3.57612365
32regulation of memory T cell differentiation (GO:0043380)3.57020620
33regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.56215138
34DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.52625524
35regulation of T cell mediated cytotoxicity (GO:0001914)3.46351366
36actin filament-based movement (GO:0030048)3.45590436
37positive regulation of defense response to virus by host (GO:0002230)3.35497487
38response to electrical stimulus (GO:0051602)3.21492023
39skeletal muscle contraction (GO:0003009)3.20006078
40response to interleukin-15 (GO:0070672)3.13011851
41pyrimidine ribonucleoside catabolic process (GO:0046133)3.11933536
42DNA damage response, signal transduction resulting in transcription (GO:0042772)3.10421062
43positive regulation of oligodendrocyte differentiation (GO:0048714)3.09817841
44protein trimerization (GO:0070206)3.07042999
45negative regulation of muscle tissue development (GO:1901862)3.05693421
46rRNA catabolic process (GO:0016075)3.01033612
47regulation of relaxation of muscle (GO:1901077)3.00903936
48fucose catabolic process (GO:0019317)2.97986574
49L-fucose metabolic process (GO:0042354)2.97986574
50L-fucose catabolic process (GO:0042355)2.97986574
51negative regulation of DNA-templated transcription, elongation (GO:0032785)2.96323484
52positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.94289667
53positive regulation of T cell mediated cytotoxicity (GO:0001916)2.93253569
54negative regulation of striated muscle tissue development (GO:0045843)2.92461706
55axoneme assembly (GO:0035082)2.90088821
56muscle adaptation (GO:0043500)2.89423696
57negative regulation of organelle assembly (GO:1902116)2.87964089
58regulation of leukocyte mediated cytotoxicity (GO:0001910)2.82648812
59regulation of muscle hypertrophy (GO:0014743)2.82397230
60regulation of centriole replication (GO:0046599)2.81251446
61RNA destabilization (GO:0050779)2.80218493
62negative regulation of muscle organ development (GO:0048635)2.80134138
63cellular ketone body metabolic process (GO:0046950)2.78853233
64response to inactivity (GO:0014854)2.78160971
65regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.77281334
66positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.77281334
67peptidyl-threonine dephosphorylation (GO:0035970)2.74998632
68negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.74119444
69alpha-beta T cell differentiation involved in immune response (GO:0002293)2.73719833
70alpha-beta T cell activation involved in immune response (GO:0002287)2.73719833
71T cell differentiation involved in immune response (GO:0002292)2.73719833
72myotube cell development (GO:0014904)2.73058310
73T-helper cell differentiation (GO:0042093)2.70825034
74CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.70825034
75positive regulation of T cell differentiation in thymus (GO:0033089)2.70258885
76heparin metabolic process (GO:0030202)2.69164837
77heparin biosynthetic process (GO:0030210)2.69164837
78regulation of regulatory T cell differentiation (GO:0045589)2.68222539
79dosage compensation (GO:0007549)2.66193094
80negative regulation of reactive oxygen species metabolic process (GO:2000378)2.65984433
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.63485806
82positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.62385185
83negative regulation of mast cell activation (GO:0033004)2.62061110
84cellular response to glucocorticoid stimulus (GO:0071385)2.61867034
85positive regulation of T-helper 1 type immune response (GO:0002827)2.61223361
86regulation of gene expression by genetic imprinting (GO:0006349)2.61172136
87positive regulation of histone H3-K4 methylation (GO:0051571)2.60490522
88regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.59972081
89regulation of endothelial cell differentiation (GO:0045601)2.58397402
90regulation of mesoderm development (GO:2000380)2.57871081
91positive regulation of endothelial cell differentiation (GO:0045603)2.56760824
92regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.56202074
93positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.56202074
94negative T cell selection (GO:0043383)2.55389717
95positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.55361699
96regulation of cell killing (GO:0031341)2.54646914
97muscle organ development (GO:0007517)2.54477503
98regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.54090632
99positive regulation of mRNA catabolic process (GO:0061014)2.52148521
100response to gravity (GO:0009629)12.3273008

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human6.08608276
2EZH2_22144423_ChIP-Seq_EOC_Human4.78777439
3FLI1_27457419_Chip-Seq_LIVER_Mouse2.97144482
4TAF15_26573619_Chip-Seq_HEK293_Human2.90414085
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.83829924
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.65198064
7AR_21572438_ChIP-Seq_LNCaP_Human2.58035394
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44313323
9ZNF274_21170338_ChIP-Seq_K562_Hela2.41995564
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35268526
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34572010
12CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.28203649
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.21826059
14GBX2_23144817_ChIP-Seq_PC3_Human2.21491911
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12441095
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11495723
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.97172489
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.94197307
19FUS_26573619_Chip-Seq_HEK293_Human1.80749251
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.78327657
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.73396307
22RUNX_20019798_ChIP-Seq_JUKART_Human1.73250267
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.71482967
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69300845
25ER_23166858_ChIP-Seq_MCF-7_Human1.68312405
26TP53_22573176_ChIP-Seq_HFKS_Human1.61629577
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60233309
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51117207
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46664223
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46559045
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.46365272
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43128897
33P300_19829295_ChIP-Seq_ESCs_Human1.42279380
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40352493
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38799488
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34435587
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33951617
38IRF1_19129219_ChIP-ChIP_H3396_Human1.33351753
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.32553545
40BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29432614
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.29403509
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.26865357
43SMAD4_21799915_ChIP-Seq_A2780_Human1.26391088
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.23586635
45CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.23556065
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23291702
47CBP_20019798_ChIP-Seq_JUKART_Human1.23159765
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23159765
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21602381
50TCF4_23295773_ChIP-Seq_U87_Human1.21225397
51STAT3_23295773_ChIP-Seq_U87_Human1.19967690
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15813679
53TDRD3_21172665_ChIP-Seq_MCF-7_Human1.13095496
54KDM2B_26808549_Chip-Seq_REH_Human1.12404346
55PRDM14_20953172_ChIP-Seq_ESCs_Human1.11336051
56BCAT_22108803_ChIP-Seq_LS180_Human1.10652847
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10223321
58GATA3_26560356_Chip-Seq_TH2_Human1.09630928
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08766689
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.08045191
61TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08021096
62RXR_22108803_ChIP-Seq_LS180_Human1.05528520
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05262413
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.05074924
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.05030817
66TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04997262
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04309668
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03974094
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.03241283
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01379626
71AR_20517297_ChIP-Seq_VCAP_Human1.00869271
72REST_21632747_ChIP-Seq_MESCs_Mouse1.00552351
73MYC_19829295_ChIP-Seq_ESCs_Human0.99252524
74CDX2_22108803_ChIP-Seq_LS180_Human0.97550406
75SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97166797
76IGF1R_20145208_ChIP-Seq_DFB_Human0.97087845
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95797033
78NCOR_22424771_ChIP-Seq_293T_Human0.95459836
79NANOG_19829295_ChIP-Seq_ESCs_Human0.94687003
80SOX2_19829295_ChIP-Seq_ESCs_Human0.94687003
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93733941
82HOXB7_26014856_ChIP-Seq_BT474_Human0.91189791
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91154603
84SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91085712
85MYC_18940864_ChIP-ChIP_HL60_Human0.91074346
86GATA3_21878914_ChIP-Seq_MCF-7_Human0.91073149
87TCF4_22108803_ChIP-Seq_LS180_Human0.90753159
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89700265
89SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89307704
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89160057
91PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88802176
92STAT1_20625510_ChIP-Seq_HELA_Human0.88497909
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88351163
94CEBPB_22108803_ChIP-Seq_LS180_Human0.88233871
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88173808
96NANOG_20526341_ChIP-Seq_ESCs_Human0.87337912
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87244788
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87137318
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.86123018
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85784845

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio5.00090610
2MP0000747_muscle_weakness3.62298758
3MP0003724_increased_susceptibility_to3.06792475
4MP0005671_abnormal_response_to2.87919084
5MP0004885_abnormal_endolymph2.76965242
6MP0004036_abnormal_muscle_relaxation2.74377038
7MP0002089_abnormal_postnatal_growth/wei2.63830484
8MP0006072_abnormal_retinal_apoptosis2.57566113
9MP0003646_muscle_fatigue2.55137053
10MP0002876_abnormal_thyroid_physiology2.47123696
11MP0001968_abnormal_touch/_nociception2.24254653
12MP0002269_muscular_atrophy2.20433506
13MP0002736_abnormal_nociception_after2.16852147
14MP0004130_abnormal_muscle_cell2.02123540
15MP0008877_abnormal_DNA_methylation2.01397765
16MP0002638_abnormal_pupillary_reflex2.00266091
17MP0000013_abnormal_adipose_tissue1.94010591
18MP0004043_abnormal_pH_regulation1.93823657
19MP0002138_abnormal_hepatobiliary_system1.93312706
20MP0004147_increased_porphyrin_level1.92232307
21MP0002102_abnormal_ear_morphology1.86582514
22MP0002106_abnormal_muscle_physiology1.80691774
23MP0000759_abnormal_skeletal_muscle1.80033090
24MP0005167_abnormal_blood-brain_barrier1.77437870
25MP0002108_abnormal_muscle_morphology1.76356717
26MP0001501_abnormal_sleep_pattern1.63697525
27MP0005620_abnormal_muscle_contractility1.60257876
28MP0008872_abnormal_physiological_respon1.52853176
29MP0005083_abnormal_biliary_tract1.51731118
30MP0004142_abnormal_muscle_tone1.51570127
31MP0000749_muscle_degeneration1.46682412
32MP0005646_abnormal_pituitary_gland1.42042455
33MP0005551_abnormal_eye_electrophysiolog1.41268815
34MP0005369_muscle_phenotype1.40307247
35MP0000427_abnormal_hair_cycle1.38736774
36MP0005253_abnormal_eye_physiology1.37833391
37MP0000465_gastrointestinal_hemorrhage1.37087421
38MP0000372_irregular_coat_pigmentation1.35994155
39MP0001986_abnormal_taste_sensitivity1.35166115
40MP0004087_abnormal_muscle_fiber1.32208374
41MP0005645_abnormal_hypothalamus_physiol1.29924111
42MP0002272_abnormal_nervous_system1.28740312
43MP0009745_abnormal_behavioral_response1.27639836
44MP0001765_abnormal_ion_homeostasis1.26779491
45MP0001486_abnormal_startle_reflex1.26720734
46MP0005000_abnormal_immune_tolerance1.26145173
47MP0003880_abnormal_central_pattern1.25289313
48MP0003959_abnormal_lean_body1.23032703
49MP0000685_abnormal_immune_system1.21998624
50MP0002095_abnormal_skin_pigmentation1.19981557
51MP0003195_calcinosis1.19536385
52MP0003045_fibrosis1.15442837
53MP0003787_abnormal_imprinting1.15039006
54MP0009780_abnormal_chondrocyte_physiolo1.14056420
55MP0002723_abnormal_immune_serum1.13822136
56MP0003763_abnormal_thymus_physiology1.13555492
57MP0005360_urolithiasis1.12420024
58MP0001800_abnormal_humoral_immune1.02977755
59MP0002837_dystrophic_cardiac_calcinosis1.02736402
60MP0004484_altered_response_of1.02575346
61MP0001919_abnormal_reproductive_system0.99894978
62MP0001661_extended_life_span0.95982656
63MP0003011_delayed_dark_adaptation0.95400334
64MP0001243_abnormal_dermal_layer0.93410997
65MP0003436_decreased_susceptibility_to0.92362240
66MP0000733_abnormal_muscle_development0.91862033
67MP0003878_abnormal_ear_physiology0.90924945
68MP0005377_hearing/vestibular/ear_phenot0.90924945
69MP0004947_skin_inflammation0.90161925
70MP0000230_abnormal_systemic_arterial0.88696891
71MP0003937_abnormal_limbs/digits/tail_de0.87724958
72MP0001485_abnormal_pinna_reflex0.87555635
73MP0003879_abnormal_hair_cell0.86990478
74MP0004270_analgesia0.86286204
75MP0001533_abnormal_skeleton_physiology0.83883948
76MP0003638_abnormal_response/metabolism_0.83071523
77MP0008875_abnormal_xenobiotic_pharmacok0.81568841
78MP0001819_abnormal_immune_cell0.80094360
79MP0005389_reproductive_system_phenotype0.78810144
80MP0004215_abnormal_myocardial_fiber0.78638469
81MP0003866_abnormal_defecation0.78185457
82MP0002009_preneoplasia0.77581631
83MP0005423_abnormal_somatic_nervous0.77471513
84MP0002420_abnormal_adaptive_immunity0.76049600
85MP0001879_abnormal_lymphatic_vessel0.75645525
86MP0005085_abnormal_gallbladder_physiolo0.75226279
87MP0001835_abnormal_antigen_presentation0.73743076
88MP0008775_abnormal_heart_ventricle0.71668456
89MP0002933_joint_inflammation0.71553459
90MP0000631_abnormal_neuroendocrine_gland0.71062621
91MP0003786_premature_aging0.69878799
92MP0001440_abnormal_grooming_behavior0.68338016
93MP0002452_abnormal_antigen_presenting0.67540308
94MP0006276_abnormal_autonomic_nervous0.67367267
95MP0001502_abnormal_circadian_rhythm0.66217720
96MP0006292_abnormal_olfactory_placode0.65175946
97MP0002557_abnormal_social/conspecific_i0.64510153
98MP0002733_abnormal_thermal_nociception0.63876809
99MP0002148_abnormal_hypersensitivity_rea0.61288143
100MP0003119_abnormal_digestive_system0.60491972

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)6.01173290
2Distal arthrogryposis (HP:0005684)5.58320445
3Nemaline bodies (HP:0003798)5.18753997
4Absent phalangeal crease (HP:0006109)5.08326575
5Exercise-induced myalgia (HP:0003738)4.68770347
6Round ear (HP:0100830)4.47573757
7IgG deficiency (HP:0004315)4.28927585
8Ulnar deviation of the wrist (HP:0003049)4.27341279
9Abnormal finger flexion creases (HP:0006143)4.23802866
10Muscle fiber inclusion bodies (HP:0100299)4.23005530
11Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.15083178
12Mask-like facies (HP:0000298)4.01718589
13Hyperkalemia (HP:0002153)3.86552999
14Congenital stationary night blindness (HP:0007642)3.49922116
15Calcaneovalgus deformity (HP:0001848)3.45718215
16Periorbital edema (HP:0100539)3.21272065
17Deformed tarsal bones (HP:0008119)3.19221182
18Conical tooth (HP:0000698)3.17118622
19Decreased circulating renin level (HP:0003351)3.16666481
20Myopathic facies (HP:0002058)3.09686390
21Facial edema (HP:0000282)3.07201655
22Type 1 muscle fiber predominance (HP:0003803)2.93859861
23Severe combined immunodeficiency (HP:0004430)2.84700729
24Oligomenorrhea (HP:0000876)2.78323187
25Stomach cancer (HP:0012126)2.76728966
26Renal cortical cysts (HP:0000803)2.68528570
27Abnormality of alanine metabolism (HP:0010916)2.66869046
28Hyperalaninemia (HP:0003348)2.66869046
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.66869046
30Nonprogressive disorder (HP:0003680)2.65322237
31Abnormality of potassium homeostasis (HP:0011042)2.64176106
32Abnormality of the renal cortex (HP:0011035)2.63667650
33Prostate neoplasm (HP:0100787)2.58243995
34Pancreatic cysts (HP:0001737)2.54303663
35Myotonia (HP:0002486)2.47635048
36Myoglobinuria (HP:0002913)2.38081875
37Neoplasm of the heart (HP:0100544)2.37677263
38Thyroiditis (HP:0100646)2.37140656
39Pancreatic fibrosis (HP:0100732)2.33857404
40Nephronophthisis (HP:0000090)2.32306171
41Abnormality of eosinophils (HP:0001879)2.29090855
42Fibular aplasia (HP:0002990)2.27828628
43Stomatitis (HP:0010280)2.25130578
44Abnormality of the renal collecting system (HP:0004742)2.24136152
45Symphalangism affecting the phalanges of the hand (HP:0009773)2.18419406
46Abolished electroretinogram (ERG) (HP:0000550)2.17927794
47Abnormal rod and cone electroretinograms (HP:0008323)2.17743372
48Supernumerary bones of the axial skeleton (HP:0009144)2.16497255
49Broad-based gait (HP:0002136)2.16328097
503-Methylglutaconic aciduria (HP:0003535)2.14991771
51Abnormality of the renal medulla (HP:0100957)2.10551020
52Aplasia/Hypoplasia of the spleen (HP:0010451)2.07436556
53Asplenia (HP:0001746)2.06931476
54Elevated erythrocyte sedimentation rate (HP:0003565)2.06809478
55True hermaphroditism (HP:0010459)2.06368562
56Keratoconus (HP:0000563)2.06011750
57Increased corneal curvature (HP:0100692)2.06011750
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00687828
59T lymphocytopenia (HP:0005403)2.00214799
60Short tibia (HP:0005736)1.99099144
61Exercise-induced muscle cramps (HP:0003710)1.98544908
62Hypokalemia (HP:0002900)1.96419268
63Decreased subcutaneous fat (HP:0001002)1.94543300
64Combined immunodeficiency (HP:0005387)1.92431231
65Abnormality of midbrain morphology (HP:0002418)1.90021085
66Molar tooth sign on MRI (HP:0002419)1.90021085
67Abnormality of T cell number (HP:0011839)1.89983685
68Aplasia/Hypoplasia of the tibia (HP:0005772)1.89568537
69Polydipsia (HP:0001959)1.86321794
70Abnormal drinking behavior (HP:0030082)1.86321794
71Clumsiness (HP:0002312)1.85672311
72Retrobulbar optic neuritis (HP:0100654)1.84819075
73Optic neuritis (HP:0100653)1.84819075
74Absent thumb (HP:0009777)1.84764133
75Methylmalonic acidemia (HP:0002912)1.83381364
76Mesomelia (HP:0003027)1.83051999
77Type II lissencephaly (HP:0007260)1.82253140
782-3 toe syndactyly (HP:0004691)1.80804533
79Attenuation of retinal blood vessels (HP:0007843)1.80402859
80Anhidrosis (HP:0000970)1.79389415
81Aplasia/hypoplasia of the uterus (HP:0008684)1.79191892
82Delayed CNS myelination (HP:0002188)1.78787449
83Metabolic acidosis (HP:0001942)1.77902743
84Hypoplasia of the uterus (HP:0000013)1.77821005
85Congenital sensorineural hearing impairment (HP:0008527)1.76949481
86Hypoplasia of the fovea (HP:0007750)1.76127650
87Aplasia/Hypoplasia of the fovea (HP:0008060)1.76127650
88Ectopic kidney (HP:0000086)1.75720660
89Pachygyria (HP:0001302)1.75548048
90Abnormality of the proximal phalanges of the hand (HP:0009834)1.74564251
91Stenosis of the external auditory canal (HP:0000402)1.74473168
92Pendular nystagmus (HP:0012043)1.73359877
93Supernumerary ribs (HP:0005815)1.72377767
94Congenital, generalized hypertrichosis (HP:0004540)1.71189435
95Abnormality of the prostate (HP:0008775)1.70257846
96Facial diplegia (HP:0001349)1.69956426
97Maternal diabetes (HP:0009800)1.69872842
98Abnormality of T cells (HP:0002843)1.69850817
99Adactyly (HP:0009776)1.68799085
100Decreased central vision (HP:0007663)1.67934644

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.89880678
2TXK4.23704012
3PHKG13.47113538
4PHKG23.47113538
5WNK43.40817368
6TIE13.27812310
7MAP2K22.96175183
8TLK12.83312013
9OBSCN2.74337357
10NUAK12.39741069
11GRK62.39014744
12MAP4K22.18405752
13MAP3K141.88750372
14PINK11.88559100
15ADRBK21.87414132
16MAPK131.81211735
17ZAK1.80526273
18JAK31.79674157
19PIK3CA1.69576881
20CAMKK21.68098361
21GRK11.64010039
22STK391.54645123
23WNK11.50938751
24FRK1.27076727
25IKBKB1.23898623
26FES1.21099682
27MUSK1.19373866
28IKBKE1.14129970
29CASK1.04950868
30SIK21.04220983
31MAPK71.03863211
32IRAK11.01573152
33OXSR10.98818036
34MAP4K10.96960732
35TEC0.92746371
36DAPK20.92153521
37EIF2AK20.90891398
38MARK30.89062655
39TYRO30.87903592
40EPHA30.87776337
41TBK10.87378036
42MST40.84070723
43PIK3CG0.83157249
44MAP2K10.83105758
45PIM10.80965841
46SYK0.79297691
47LIMK10.73344335
48TESK20.72314633
49ACVR1B0.72023990
50CHEK20.64758706
51TNIK0.64547709
52JAK10.63828600
53GRK70.62263332
54ITK0.60942767
55RPS6KA20.60613916
56KIT0.59615895
57CDK40.58650160
58CAMKK10.57994383
59CAMK10.53465008
60BCKDK0.52249155
61LCK0.52003163
62BMPR1B0.51520928
63CAMK1D0.49934642
64PRKCQ0.48833420
65TRPM70.48279938
66MAPKAPK30.48076219
67SGK20.47971366
68RPS6KA60.47588633
69CHUK0.46954090
70WNK30.46258229
71SGK4940.45742884
72SGK2230.45742884
73KDR0.45550354
74CSF1R0.43574185
75CSNK1G20.43382132
76IGF1R0.42732672
77SGK10.42649293
78NLK0.42491214
79TNK20.41870359
80DYRK1B0.41386699
81PRKG10.39709298
82PRKCE0.39470309
83INSRR0.38546788
84GRK50.38138192
85RPS6KA40.36751382
86NTRK20.36703543
87BTK0.35757432
88CAMK40.35319569
89PRKACA0.35256389
90AURKA0.33067316
91LYN0.32897586
92CAMK2G0.31864825
93MAPK120.30701419
94RPS6KC10.30690864
95RPS6KL10.30690864
96RPS6KA50.29907669
97RPS6KA30.29620136
98PRKAA20.29588701
99ADRBK10.29328982
100MAP2K60.28370520

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.16303936
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.64204625
3Regulation of autophagy_Homo sapiens_hsa041402.60213376
4Primary immunodeficiency_Homo sapiens_hsa053402.54614201
5Linoleic acid metabolism_Homo sapiens_hsa005912.21130112
6Tight junction_Homo sapiens_hsa045302.15110406
7Nicotine addiction_Homo sapiens_hsa050332.10798890
8Morphine addiction_Homo sapiens_hsa050322.05823216
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.00843611
10Phototransduction_Homo sapiens_hsa047441.95632455
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83284771
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.77164964
13Circadian entrainment_Homo sapiens_hsa047131.76287919
14Oxytocin signaling pathway_Homo sapiens_hsa049211.66559187
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65501529
16Graft-versus-host disease_Homo sapiens_hsa053321.64732155
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63595216
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61219670
19Renin secretion_Homo sapiens_hsa049241.61137967
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60225649
21Insulin secretion_Homo sapiens_hsa049111.51268284
22Caffeine metabolism_Homo sapiens_hsa002321.50898123
23T cell receptor signaling pathway_Homo sapiens_hsa046601.49934292
24Asthma_Homo sapiens_hsa053101.47608962
25GABAergic synapse_Homo sapiens_hsa047271.45206212
26Calcium signaling pathway_Homo sapiens_hsa040201.43792529
27Circadian rhythm_Homo sapiens_hsa047101.43420574
28Allograft rejection_Homo sapiens_hsa053301.43231058
29Gastric acid secretion_Homo sapiens_hsa049711.43001111
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.39639005
31Olfactory transduction_Homo sapiens_hsa047401.34954463
32Autoimmune thyroid disease_Homo sapiens_hsa053201.31673996
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.29590287
34Tryptophan metabolism_Homo sapiens_hsa003801.28038193
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27357233
36RNA degradation_Homo sapiens_hsa030181.26095624
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26004496
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21978478
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21057018
40Serotonergic synapse_Homo sapiens_hsa047261.19674123
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17912034
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17909598
43Chemical carcinogenesis_Homo sapiens_hsa052041.14964597
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.14856464
45Cardiac muscle contraction_Homo sapiens_hsa042601.13386299
46Ether lipid metabolism_Homo sapiens_hsa005651.12709087
47Taste transduction_Homo sapiens_hsa047421.10779219
48Cholinergic synapse_Homo sapiens_hsa047251.03744881
49Salivary secretion_Homo sapiens_hsa049701.03362595
50Arachidonic acid metabolism_Homo sapiens_hsa005901.01538801
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99298459
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.98957885
53Amphetamine addiction_Homo sapiens_hsa050310.97980021
54Dopaminergic synapse_Homo sapiens_hsa047280.90198687
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87973167
56Fat digestion and absorption_Homo sapiens_hsa049750.87143284
57Retinol metabolism_Homo sapiens_hsa008300.87086779
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86914754
59Type I diabetes mellitus_Homo sapiens_hsa049400.85225032
60Basal transcription factors_Homo sapiens_hsa030220.82798943
61Antigen processing and presentation_Homo sapiens_hsa046120.82738015
62Fanconi anemia pathway_Homo sapiens_hsa034600.81455485
63Arginine biosynthesis_Homo sapiens_hsa002200.81365947
64Butanoate metabolism_Homo sapiens_hsa006500.76325588
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75909347
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74767717
67Glutamatergic synapse_Homo sapiens_hsa047240.73559453
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70590365
69cAMP signaling pathway_Homo sapiens_hsa040240.68913916
70Hedgehog signaling pathway_Homo sapiens_hsa043400.64830366
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63724579
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63177014
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62251787
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61065913
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.60872762
76Selenocompound metabolism_Homo sapiens_hsa004500.60466284
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57456724
78ABC transporters_Homo sapiens_hsa020100.57058393
79Long-term depression_Homo sapiens_hsa047300.55413253
80Pancreatic secretion_Homo sapiens_hsa049720.55378289
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.54776208
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54576513
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53846076
84Sulfur metabolism_Homo sapiens_hsa009200.50884358
85Peroxisome_Homo sapiens_hsa041460.50035253
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.49076843
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48195509
88Rheumatoid arthritis_Homo sapiens_hsa053230.48187792
89Platelet activation_Homo sapiens_hsa046110.46013543
90Dorso-ventral axis formation_Homo sapiens_hsa043200.45641038
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45618139
92MAPK signaling pathway_Homo sapiens_hsa040100.45136722
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43343623
94Hematopoietic cell lineage_Homo sapiens_hsa046400.42920503
95Long-term potentiation_Homo sapiens_hsa047200.42319050
96Dilated cardiomyopathy_Homo sapiens_hsa054140.37687905
97Ovarian steroidogenesis_Homo sapiens_hsa049130.37645776
98Alzheimers disease_Homo sapiens_hsa050100.37578150
99Glucagon signaling pathway_Homo sapiens_hsa049220.34832449
100Sulfur relay system_Homo sapiens_hsa041220.34243189

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