ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.38114082
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.27792415
3	ATP synthesis coupled proton transport (GO:0015986)	5.27792415
4	behavioral response to nicotine (GO:0035095)	4.97204040
5	cellular ketone body metabolic process (GO:0046950)	4.72466859
6	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.42774774
7	NADH dehydrogenase complex assembly (GO:0010257)	4.42774774
8	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.42774774
9	L-fucose catabolic process (GO:0042355)	4.28739800
10	fucose catabolic process (GO:0019317)	4.28739800
11	L-fucose metabolic process (GO:0042354)	4.28739800
12	protein complex biogenesis (GO:0070271)	4.22842161
13	ketone body metabolic process (GO:1902224)	4.17501861
14	mitochondrial calcium ion transport (GO:0006851)	3.93108904
15	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.87917954
16	mitochondrial respiratory chain complex assembly (GO:0033108)	3.79500259
17	respiratory chain complex IV assembly (GO:0008535)	3.76385589
18	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	3.68857192
19	water-soluble vitamin biosynthetic process (GO:0042364)	3.68724276
20	kynurenine metabolic process (GO:0070189)	3.65472692
21	electron transport chain (GO:0022900)	3.42020495
22	cytidine deamination (GO:0009972)	3.35348639
23	cytidine metabolic process (GO:0046087)	3.35348639
24	cytidine catabolic process (GO:0006216)	3.35348639
25	indole-containing compound catabolic process (GO:0042436)	3.33363784
26	indolalkylamine catabolic process (GO:0046218)	3.33363784
27	tryptophan catabolic process (GO:0006569)	3.33363784
28	indolalkylamine metabolic process (GO:0006586)	3.31785925
29	respiratory electron transport chain (GO:0022904)	3.29916042
30	platelet dense granule organization (GO:0060155)	3.29409118
31	pseudouridine synthesis (GO:0001522)	3.27428125
32	ATP biosynthetic process (GO:0006754)	3.27256653
33	cytochrome complex assembly (GO:0017004)	3.24688933
34	preassembly of GPI anchor in ER membrane (GO:0016254)	3.22066013
35	detection of light stimulus involved in sensory perception (GO:0050962)	3.20646959
36	detection of light stimulus involved in visual perception (GO:0050908)	3.20646959
37	drug catabolic process (GO:0042737)	3.20208401
38	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.19990362
39	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.14634247
40	cellular response to ATP (GO:0071318)	3.11393598
41	vitamin transmembrane transport (GO:0035461)	3.09025903
42	mitochondrial calcium ion homeostasis (GO:0051560)	3.07736106
43	dopamine transport (GO:0015872)	3.06293552
44	hydrogen ion transmembrane transport (GO:1902600)	3.03284988
45	coenzyme catabolic process (GO:0009109)	3.03039127
46	maturation of 5.8S rRNA (GO:0000460)	3.00767245
47	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.99863684
48	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.99637194
49	protein prenylation (GO:0018342)	2.99331371
50	prenylation (GO:0097354)	2.99331371
51	proton transport (GO:0015992)	2.93546823
52	fat-soluble vitamin catabolic process (GO:0042363)	2.91806104
53	vitamin catabolic process (GO:0009111)	2.91806104
54	mannosylation (GO:0097502)	2.90539951
55	hydrogen transport (GO:0006818)	2.88390772
56	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.80369140
57	rRNA catabolic process (GO:0016075)	2.80255408
58	basic amino acid transport (GO:0015802)	2.80206438
59	response to pheromone (GO:0019236)	2.80137073
60	tryptophan metabolic process (GO:0006568)	2.80005352
61	protein K6-linked ubiquitination (GO:0085020)	2.78426651
62	negative regulation of telomere maintenance (GO:0032205)	2.78166532
63	piRNA metabolic process (GO:0034587)	2.77561191
64	regulation of glucokinase activity (GO:0033131)	2.74708099
65	regulation of hexokinase activity (GO:1903299)	2.74708099
66	positive regulation of fatty acid transport (GO:2000193)	2.73731827
67	positive regulation of defense response to virus by host (GO:0002230)	2.73603520
68	mRNA cleavage (GO:0006379)	2.62687921
69	kidney morphogenesis (GO:0060993)	2.61310975
70	S-adenosylmethionine metabolic process (GO:0046500)	2.56844849
71	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.56366603
72	sulfation (GO:0051923)	2.55669858
73	glycerophospholipid catabolic process (GO:0046475)	2.55460430
74	magnesium ion transport (GO:0015693)	2.54997918
75	multicellular organism reproduction (GO:0032504)	2.54938868
76	exogenous drug catabolic process (GO:0042738)	2.50963324
77	aromatic amino acid family catabolic process (GO:0009074)	2.50953458
78	negative regulation of acute inflammatory response (GO:0002674)	2.49263706
79	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.48071401
80	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.47368078
81	oxidative demethylation (GO:0070989)	2.47195607
82	insulin secretion (GO:0030073)	2.46430605
83	proline transport (GO:0015824)	2.43880038
84	mitotic cell cycle arrest (GO:0071850)	2.43520387
85	positive regulation of icosanoid secretion (GO:0032305)	2.41214851
86	regulation of memory T cell differentiation (GO:0043380)	2.40127539
87	protein K11-linked deubiquitination (GO:0035871)	2.39137663
88	endoderm formation (GO:0001706)	2.38661357
89	endocrine pancreas development (GO:0031018)	2.36804942
90	polyol catabolic process (GO:0046174)	2.33273278
91	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.33272098
92	inositol phosphate dephosphorylation (GO:0046855)	2.33272098
93	regulation of DNA endoreduplication (GO:0032875)	2.32641199
94	inositol phosphate catabolic process (GO:0071545)	2.32496414
95	negative regulation of mast cell activation (GO:0033004)	2.30479836
96	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.30286510
97	protein-cofactor linkage (GO:0018065)	2.29471456
98	indole-containing compound metabolic process (GO:0042430)	2.28539566
99	regulation of T cell mediated cytotoxicity (GO:0001914)	2.27677157
100	thyroid hormone metabolic process (GO:0042403)	2.26640508

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.54405785
2	VDR_22108803_ChIP-Seq_LS180_Human	3.17101069
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.79627344
4	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.61945944
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.26314131
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.07732123
7	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.03081732
8	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.01008729
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.98752260
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.97685689
11	TP53_22573176_ChIP-Seq_HFKS_Human	1.92782069
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.91390561
13	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.88446990
14	MYC_18940864_ChIP-ChIP_HL60_Human	1.85092582
15	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.84082773
16	EWS_26573619_Chip-Seq_HEK293_Human	1.80750825
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.79283614
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.76592619
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.75919011
20	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.73426352
21	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.73064642
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.70788464
23	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.70219082
24	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.70219082
25	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.67643087
26	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.65767519
27	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.59276856
28	FUS_26573619_Chip-Seq_HEK293_Human	1.57767656
29	AR_20517297_ChIP-Seq_VCAP_Human	1.56474320
30	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.56006633
31	VDR_23849224_ChIP-Seq_CD4+_Human	1.54234965
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.53624444
33	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.50930430
34	GATA3_26560356_Chip-Seq_TH2_Human	1.50448529
35	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.50248697
36	NCOR_22424771_ChIP-Seq_293T_Human	1.49522865
37	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.46897715
38	HTT_18923047_ChIP-ChIP_STHdh_Human	1.44488334
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.41854379
40	ERA_21632823_ChIP-Seq_H3396_Human	1.40117606
41	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.38149937
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37230366
43	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37230366
44	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.36507252
45	TAF2_19829295_ChIP-Seq_ESCs_Human	1.35781782
46	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.35207571
47	P53_21459846_ChIP-Seq_SAOS-2_Human	1.35126445
48	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.34223688
49	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.34107518
50	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.33016777
51	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.32079538
52	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.31032726
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31025513
54	MYC_19829295_ChIP-Seq_ESCs_Human	1.29856408
55	NANOG_20526341_ChIP-Seq_ESCs_Human	1.29448402
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29050141
57	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.28918472
58	FOXP3_21729870_ChIP-Seq_TREG_Human	1.28299134
59	HOXB7_26014856_ChIP-Seq_BT474_Human	1.26443851
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.24035735
61	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.23823207
62	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.23412475
63	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.23127516
64	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.22798131
65	BCAT_22108803_ChIP-Seq_LS180_Human	1.20908209
66	P300_19829295_ChIP-Seq_ESCs_Human	1.19700249
67	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18550543
68	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.15602136
69	GBX2_23144817_ChIP-Seq_PC3_Human	1.14031166
70	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.12914505
71	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.12689948
72	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12108160
73	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11698231
74	TCF4_23295773_ChIP-Seq_U87_Human	1.11637434
75	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.10131260
76	ERG_20517297_ChIP-Seq_VCAP_Human	1.09613972
77	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.09444612
78	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.09067716
79	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.07589730
80	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07431963
81	PHF8_20622853_ChIP-Seq_HELA_Human	1.07382763
82	OCT4_20526341_ChIP-Seq_ESCs_Human	1.06803941
83	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.06462054
84	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.05707059
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05568798
86	RBPJ_21746931_ChIP-Seq_IB4_Human	1.03280750
87	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.02396349
88	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.01538116
89	CBP_20019798_ChIP-Seq_JUKART_Human	1.01538116
90	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.00189223
91	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.99689610
92	STAT3_23295773_ChIP-Seq_U87_Human	0.99388436
93	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.98955584
94	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98186802
95	RAC3_21632823_ChIP-Seq_H3396_Human	0.97895192
96	NFYB_21822215_ChIP-Seq_K562_Human	0.97712308
97	ETV1_20927104_ChIP-Seq_GIST48_Human	0.97080033
98	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.96348781
99	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.96243439
100	TCF4_22108803_ChIP-Seq_LS180_Human	0.95448792

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005645_abnormal_hypothalamus_physiol	3.21676937
2	MP0002837_dystrophic_cardiac_calcinosis	3.07922900
3	MP0004043_abnormal_pH_regulation	3.07232007
4	MP0003195_calcinosis	3.00973325
5	MP0002876_abnormal_thyroid_physiology	2.62448208
6	MP0002138_abnormal_hepatobiliary_system	2.49976887
7	MP0005646_abnormal_pituitary_gland	2.41045206
8	MP0005671_abnormal_response_to	2.35934082
9	MP0003646_muscle_fatigue	2.30778083
10	MP0008877_abnormal_DNA_methylation	2.22442896
11	MP0008872_abnormal_physiological_respon	2.22013801
12	MP0005379_endocrine/exocrine_gland_phen	2.20771470
13	MP0002163_abnormal_gland_morphology	2.16134251
14	MP0004885_abnormal_endolymph	2.07053579
15	MP0005360_urolithiasis	2.02215796
16	MP0000013_abnormal_adipose_tissue	1.82534852
17	MP0002102_abnormal_ear_morphology	1.81473796
18	MP0004147_increased_porphyrin_level	1.81399560
19	MP0006036_abnormal_mitochondrial_physio	1.80503396
20	MP0002139_abnormal_hepatobiliary_system	1.79854677
21	MP0002693_abnormal_pancreas_physiology	1.75772976
22	MP0005551_abnormal_eye_electrophysiolog	1.73440815
23	MP0008875_abnormal_xenobiotic_pharmacok	1.66011684
24	MP0005332_abnormal_amino_acid	1.64415068
25	MP0001968_abnormal_touch/_nociception	1.64046319
26	MP0002909_abnormal_adrenal_gland	1.60880224
27	MP0004145_abnormal_muscle_electrophysio	1.57240941
28	MP0002653_abnormal_ependyma_morphology	1.56088324
29	MP0005389_reproductive_system_phenotype	1.53596027
30	MP0002160_abnormal_reproductive_system	1.51977795
31	MP0006072_abnormal_retinal_apoptosis	1.49384068
32	MP0001764_abnormal_homeostasis	1.48581826
33	MP0002166_altered_tumor_susceptibility	1.48292957
34	MP0002638_abnormal_pupillary_reflex	1.47777264
35	MP0003693_abnormal_embryo_hatching	1.46168726
36	MP0001986_abnormal_taste_sensitivity	1.42708510
37	MP0001944_abnormal_pancreas_morphology	1.42302834
38	MP0003283_abnormal_digestive_organ	1.41688465
39	MP0001919_abnormal_reproductive_system	1.37157935
40	MP0001835_abnormal_antigen_presentation	1.35269508
41	MP0004019_abnormal_vitamin_homeostasis	1.34354139
42	MP0010329_abnormal_lipoprotein_level	1.31592757
43	MP0001661_extended_life_span	1.31465203
44	MP0000685_abnormal_immune_system	1.29237645
45	MP0009046_muscle_twitch	1.28261410
46	MP0004130_abnormal_muscle_cell	1.26731423
47	MP0001765_abnormal_ion_homeostasis	1.26491479
48	MP0009745_abnormal_behavioral_response	1.25583436
49	MP0002006_tumorigenesis	1.23976223
50	MP0002009_preneoplasia	1.21987654
51	MP0001485_abnormal_pinna_reflex	1.20478499
52	MP0000372_irregular_coat_pigmentation	1.18492977
53	MP0005670_abnormal_white_adipose	1.16634191
54	MP0005636_abnormal_mineral_homeostasis	1.16068942
55	MP0009333_abnormal_splenocyte_physiolog	1.15847269
56	MP0001790_abnormal_immune_system	1.12798382
57	MP0005387_immune_system_phenotype	1.12798382
58	MP0005174_abnormal_tail_pigmentation	1.12654103
59	MP0003724_increased_susceptibility_to	1.12100506
60	MP0001501_abnormal_sleep_pattern	1.10046073
61	MP0002928_abnormal_bile_duct	1.08364207
62	MP0004142_abnormal_muscle_tone	1.06424247
63	MP0009697_abnormal_copulation	1.06373013
64	MP0001873_stomach_inflammation	1.06137614
65	MP0006276_abnormal_autonomic_nervous	1.05791964
66	MP0002272_abnormal_nervous_system	1.04965015
67	MP0005365_abnormal_bile_salt	1.03022785
68	MP0002736_abnormal_nociception_after	1.01373066
69	MP0002733_abnormal_thermal_nociception	0.99343497
70	MP0000427_abnormal_hair_cycle	0.98079295
71	MP0002148_abnormal_hypersensitivity_rea	0.97714345
72	MP0000230_abnormal_systemic_arterial	0.97250235
73	MP0005085_abnormal_gallbladder_physiolo	0.96555529
74	MP0000631_abnormal_neuroendocrine_gland	0.95781156
75	MP0001970_abnormal_pain_threshold	0.94891937
76	MP0009643_abnormal_urine_homeostasis	0.94671780
77	MP0005410_abnormal_fertilization	0.94045972
78	MP0005448_abnormal_energy_balance	0.93588432
79	MP0001800_abnormal_humoral_immune	0.92391014
80	MP0003787_abnormal_imprinting	0.92145818
81	MP0001905_abnormal_dopamine_level	0.92069778
82	MP0003879_abnormal_hair_cell	0.92042080
83	MP0005253_abnormal_eye_physiology	0.91311685
84	MP0003252_abnormal_bile_duct	0.90865659
85	MP0008775_abnormal_heart_ventricle	0.89830265
86	MP0002078_abnormal_glucose_homeostasis	0.89678172
87	MP0005000_abnormal_immune_tolerance	0.87538220
88	MP0003806_abnormal_nucleotide_metabolis	0.86950703
89	MP0001502_abnormal_circadian_rhythm	0.83230945
90	MP0003011_delayed_dark_adaptation	0.80105232
91	MP0002277_abnormal_respiratory_mucosa	0.79958158
92	MP0005075_abnormal_melanosome_morpholog	0.79526361
93	MP0002938_white_spotting	0.79080158
94	MP0003718_maternal_effect	0.78249515
95	MP0005167_abnormal_blood-brain_barrier	0.76196805
96	MP0001756_abnormal_urination	0.75043099
97	MP0003638_abnormal_response/metabolism_	0.73991195
98	MP0003953_abnormal_hormone_level	0.73303770
99	MP0002723_abnormal_immune_serum	0.72975176
100	MP0009785_altered_susceptibility_to	0.72867785

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.18900903
2	Abnormality of alanine metabolism (HP:0010916)	4.18900903
3	Hyperalaninemia (HP:0003348)	4.18900903
4	Pancreatic cysts (HP:0001737)	3.72740037
5	Congenital stationary night blindness (HP:0007642)	3.62201695
6	Ketoacidosis (HP:0001993)	3.29277589
7	Abnormality of the renal cortex (HP:0011035)	3.10075248
8	Decreased circulating renin level (HP:0003351)	3.09182584
9	Acute necrotizing encephalopathy (HP:0006965)	3.02621222
10	Pancreatic fibrosis (HP:0100732)	2.92600180
11	Abnormal rod and cone electroretinograms (HP:0008323)	2.87849147
12	Ketosis (HP:0001946)	2.85668952
13	Abolished electroretinogram (ERG) (HP:0000550)	2.84555229
14	Polydipsia (HP:0001959)	2.77008319
15	Abnormal drinking behavior (HP:0030082)	2.77008319
16	Type II lissencephaly (HP:0007260)	2.76249456
17	Attenuation of retinal blood vessels (HP:0007843)	2.67030011
18	Progressive macrocephaly (HP:0004481)	2.66946756
19	Mitochondrial inheritance (HP:0001427)	2.66779620
20	Acute encephalopathy (HP:0006846)	2.64220805
21	Increased CSF lactate (HP:0002490)	2.63838150
22	Abnormal mitochondria in muscle tissue (HP:0008316)	2.62130269
23	Renal cortical cysts (HP:0000803)	2.56999844
24	Decreased central vision (HP:0007663)	2.56200005
25	Pendular nystagmus (HP:0012043)	2.55647595
26	Abnormality of midbrain morphology (HP:0002418)	2.50367274
27	Molar tooth sign on MRI (HP:0002419)	2.50367274
28	Hypoglycemic coma (HP:0001325)	2.47832489
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.40567309
30	Methylmalonic acidemia (HP:0002912)	2.38847960
31	True hermaphroditism (HP:0010459)	2.35555169
32	Aplasia/hypoplasia of the uterus (HP:0008684)	2.35052678
33	3-Methylglutaconic aciduria (HP:0003535)	2.30420821
34	Alkalosis (HP:0001948)	2.28118886
35	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.26363086
36	Hyperinsulinemic hypoglycemia (HP:0000825)	2.25945087
37	IgG deficiency (HP:0004315)	2.25734502
38	Lipid accumulation in hepatocytes (HP:0006561)	2.24730229
39	Hepatic necrosis (HP:0002605)	2.24240686
40	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.23649310
41	Inability to walk (HP:0002540)	2.22111284
42	Metabolic alkalosis (HP:0200114)	2.18484605
43	Glycosuria (HP:0003076)	2.18474490
44	Abnormality of urine glucose concentration (HP:0011016)	2.18474490
45	Polyuria (HP:0000103)	2.16851008
46	Large for gestational age (HP:0001520)	2.14554432
47	Confusion (HP:0001289)	2.14144956
48	Generalized aminoaciduria (HP:0002909)	2.13991249
49	Tongue fasciculations (HP:0001308)	2.12243897
50	Cerebral edema (HP:0002181)	2.11379043
51	Congenital sensorineural hearing impairment (HP:0008527)	2.09658692
52	Hypoplasia of the uterus (HP:0000013)	2.08529868
53	Constricted visual fields (HP:0001133)	2.06117630
54	Increased serum lactate (HP:0002151)	2.04543898
55	Methylmalonic aciduria (HP:0012120)	2.04438735
56	Nephronophthisis (HP:0000090)	2.02669671
57	Abnormality of renin-angiotensin system (HP:0000847)	2.02570949
58	Lethargy (HP:0001254)	2.02037683
59	Abnormality of vitamin B metabolism (HP:0004340)	2.01867416
60	Abnormal urine output (HP:0012590)	2.01677864
61	Absent/shortened dynein arms (HP:0200106)	2.01226066
62	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.01226066
63	Keratoconus (HP:0000563)	1.98453518
64	Increased corneal curvature (HP:0100692)	1.98453518
65	Furrowed tongue (HP:0000221)	1.96013675
66	Medial flaring of the eyebrow (HP:0010747)	1.95863494
67	Oral leukoplakia (HP:0002745)	1.95755552
68	Lactic acidosis (HP:0003128)	1.94868807
69	Stomatitis (HP:0010280)	1.94286029
70	Asplenia (HP:0001746)	1.93710730
71	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.93139500
72	Short 1st metacarpal (HP:0010034)	1.93139500
73	Severe muscular hypotonia (HP:0006829)	1.92553999
74	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.91116367
75	Hyperglycemia (HP:0003074)	1.87881436
76	Abnormality of the renal medulla (HP:0100957)	1.87059265
77	Optic disc pallor (HP:0000543)	1.86147098
78	Ectopic kidney (HP:0000086)	1.85397893
79	Abnormality of renal excretion (HP:0011036)	1.85144033
80	Tubular atrophy (HP:0000092)	1.84855988
81	Chorioretinal atrophy (HP:0000533)	1.84299468
82	Hepatocellular necrosis (HP:0001404)	1.84013171
83	Tinnitus (HP:0000360)	1.83507199
84	Increased hepatocellular lipid droplets (HP:0006565)	1.82197741
85	Bile duct proliferation (HP:0001408)	1.81867131
86	Abnormal biliary tract physiology (HP:0012439)	1.81867131
87	Symptomatic seizures (HP:0011145)	1.81602910
88	Congenital, generalized hypertrichosis (HP:0004540)	1.80265460
89	Absent thumb (HP:0009777)	1.80013487
90	Thyroiditis (HP:0100646)	1.78783469
91	Abnormality of T cell physiology (HP:0011840)	1.78351926
92	Tachypnea (HP:0002789)	1.78131867
93	Severe combined immunodeficiency (HP:0004430)	1.76347165
94	Cystic liver disease (HP:0006706)	1.76215250
95	Hypothermia (HP:0002045)	1.74436802
96	Metabolic acidosis (HP:0001942)	1.73168136
97	Abnormality of the renal collecting system (HP:0004742)	1.72099026
98	Hypomagnesemia (HP:0002917)	1.71495847
99	Abnormality of the 1st metacarpal (HP:0010009)	1.71212931
100	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.69164862

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ADRBK2	4.47946030
2	FRK	4.32630831
3	TAOK3	4.07323362
4	TLK1	3.74364461
5	GRK1	3.30597259
6	PINK1	2.98941063
7	WNK4	2.78886438
8	DAPK2	2.66762648
9	VRK2	2.36522278
10	ZAK	2.28826425
11	MAP4K2	2.23698647
12	PHKG1	2.17337142
13	PHKG2	2.17337142
14	BMPR1B	2.05655981
15	TXK	1.97975719
16	NUAK1	1.93470493
17	ACVR1B	1.83531557
18	MAP2K6	1.66153605
19	BLK	1.34826445
20	MST4	1.34777992
21	STK3	1.33310551
22	WNK3	1.32703290
23	SYK	1.26171571
24	MAP4K1	1.23287451
25	EIF2AK3	1.21641994
26	TIE1	1.14724725
27	STK16	1.14318879
28	MAPKAPK3	1.13123730
29	GRK6	1.12169532
30	TEC	1.11471216
31	STK39	1.03609550
32	TNK2	1.02004516
33	ITK	1.02004296
34	ADRBK1	1.00322948
35	VRK1	0.98929608
36	BCKDK	0.97015200
37	CAMKK2	0.95483370
38	MAP2K2	0.94485654
39	MAP3K9	0.93816529
40	TRPM7	0.92288010
41	IKBKB	0.92161967
42	CSNK1G3	0.91468606
43	INSRR	0.90876913
44	OXSR1	0.89705754
45	TAF1	0.81877713
46	CSNK1G1	0.79709654
47	HIPK2	0.78014905
48	MAPKAPK5	0.71577536
49	CSNK1G2	0.69837902
50	CHEK2	0.69275864
51	CAMK1	0.69124343
52	EIF2AK2	0.67052907
53	PIK3CG	0.65048130
54	CSNK1A1	0.64906945
55	PRKCQ	0.63245011
56	ATR	0.62983277
57	OBSCN	0.62845048
58	KDR	0.61318816
59	STK24	0.59948828
60	PASK	0.59413977
61	PRKCE	0.57501769
62	CSNK1A1L	0.57100698
63	PRKCG	0.54056067
64	MUSK	0.53897726
65	RPS6KA5	0.53163134
66	PRKCI	0.51790728
67	MAP3K12	0.51774399
68	GRK5	0.51678756
69	MAPK11	0.51573516
70	NME1	0.50107763
71	FES	0.49430411
72	PRKAA2	0.48078424
73	KIT	0.46916184
74	LYN	0.46589041
75	MAPK13	0.46472631
76	NEK9	0.46104379
77	PRKCH	0.45889737
78	PTK2B	0.45133325
79	NLK	0.44361288
80	WNK1	0.43802225
81	RPS6KA6	0.41893695
82	PRKACA	0.40916089
83	ZAP70	0.39806086
84	FGFR2	0.38118900
85	PRKG1	0.37935976
86	BTK	0.37719971
87	PRKCA	0.37302586
88	BUB1	0.36987587
89	LCK	0.36814991
90	MAP2K1	0.36665923
91	PLK2	0.36382119
92	CAMK4	0.34881291
93	IKBKE	0.34275862
94	MAP3K4	0.34174876
95	PIK3CA	0.34015486
96	GRK7	0.33992414
97	DYRK2	0.33639461
98	BRSK2	0.33210560
99	CAMK2A	0.32821596
100	PIM1	0.32385561

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.66937201
2	Sulfur metabolism_Homo sapiens_hsa00920	3.14572126
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.64870605
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.53263038
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.33667028
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.29256477
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.15382460
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.01440089
9	One carbon pool by folate_Homo sapiens_hsa00670	1.95185061
10	Parkinsons disease_Homo sapiens_hsa05012	1.90537984
11	Phototransduction_Homo sapiens_hsa04744	1.90255700
12	Type I diabetes mellitus_Homo sapiens_hsa04940	1.87788614
13	Homologous recombination_Homo sapiens_hsa03440	1.83376101
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.81448437
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.76755542
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.74676206
17	Asthma_Homo sapiens_hsa05310	1.74507266
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.70694562
19	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.65223820
20	RNA polymerase_Homo sapiens_hsa03020	1.62048169
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.60529292
22	Sulfur relay system_Homo sapiens_hsa04122	1.56853367
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.56667479
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.50705603
25	Butanoate metabolism_Homo sapiens_hsa00650	1.50434902
26	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.45786610
27	Allograft rejection_Homo sapiens_hsa05330	1.44773659
28	Protein export_Homo sapiens_hsa03060	1.41958271
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.40171924
30	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.38020412
31	Retinol metabolism_Homo sapiens_hsa00830	1.35894507
32	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.34027224
33	Chemical carcinogenesis_Homo sapiens_hsa05204	1.32534817
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.31951962
35	Alzheimers disease_Homo sapiens_hsa05010	1.31446844
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.29408107
37	Peroxisome_Homo sapiens_hsa04146	1.27979683
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.26734118
39	Ether lipid metabolism_Homo sapiens_hsa00565	1.26641329
40	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.24752667
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.23297066
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.22810559
43	Graft-versus-host disease_Homo sapiens_hsa05332	1.22442135
44	RNA degradation_Homo sapiens_hsa03018	1.22320138
45	Caffeine metabolism_Homo sapiens_hsa00232	1.21535119
46	Insulin secretion_Homo sapiens_hsa04911	1.18716299
47	Cardiac muscle contraction_Homo sapiens_hsa04260	1.16322906
48	Basal transcription factors_Homo sapiens_hsa03022	1.13523531
49	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.04567609
50	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.01717406
51	Huntingtons disease_Homo sapiens_hsa05016	1.00947693
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.97500099
53	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.97492453
54	Purine metabolism_Homo sapiens_hsa00230	0.91665139
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.91512306
56	Olfactory transduction_Homo sapiens_hsa04740	0.91131593
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.91119160
58	Histidine metabolism_Homo sapiens_hsa00340	0.89792672
59	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.86371471
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.83297545
61	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.81406200
62	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.81044045
63	Pyrimidine metabolism_Homo sapiens_hsa00240	0.79564866
64	Serotonergic synapse_Homo sapiens_hsa04726	0.76801168
65	Ribosome_Homo sapiens_hsa03010	0.74932380
66	Morphine addiction_Homo sapiens_hsa05032	0.74664389
67	Fanconi anemia pathway_Homo sapiens_hsa03460	0.73222016
68	Folate biosynthesis_Homo sapiens_hsa00790	0.68339960
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66914334
70	Metabolic pathways_Homo sapiens_hsa01100	0.64784824
71	Nicotine addiction_Homo sapiens_hsa05033	0.63115704
72	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.62411618
73	Rheumatoid arthritis_Homo sapiens_hsa05323	0.61766744
74	Taste transduction_Homo sapiens_hsa04742	0.61514212
75	Propanoate metabolism_Homo sapiens_hsa00640	0.61039496
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.60682634
77	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.59949640
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.59127101
79	Proteasome_Homo sapiens_hsa03050	0.57081379
80	Mineral absorption_Homo sapiens_hsa04978	0.55405334
81	Regulation of autophagy_Homo sapiens_hsa04140	0.55185161
82	ABC transporters_Homo sapiens_hsa02010	0.54673361
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.53349855
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.53140190
85	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.52659759
86	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.48543187
87	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.46716463
88	Renin-angiotensin system_Homo sapiens_hsa04614	0.43591255
89	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.43465372
90	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.39362550
91	Circadian entrainment_Homo sapiens_hsa04713	0.37515997
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.37105112
93	Nucleotide excision repair_Homo sapiens_hsa03420	0.35480132
94	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.35461446
95	Fatty acid degradation_Homo sapiens_hsa00071	0.34248543
96	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.33663136
97	Renin secretion_Homo sapiens_hsa04924	0.33207441
98	Arginine biosynthesis_Homo sapiens_hsa00220	0.33151952
99	Antigen processing and presentation_Homo sapiens_hsa04612	0.33135413
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.32315886

MTND5P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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