MTND5P14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.18985637
2detection of molecule of bacterial origin (GO:0032490)5.99269688
3positive regulation of B cell differentiation (GO:0045579)5.41753926
4regulation of gamma-delta T cell activation (GO:0046643)5.38916623
5positive regulation by symbiont of host defense response (GO:0052509)5.22350830
6modulation by symbiont of host defense response (GO:0052031)5.22350830
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.22350830
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.22350830
9positive regulation by organism of defense response of other organism involved in symbiotic interact5.22350830
10modulation by symbiont of host immune response (GO:0052553)5.22350830
11regulation of B cell receptor signaling pathway (GO:0050855)5.17515256
12positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.02852785
13response to peptidoglycan (GO:0032494)4.98041529
14neutrophil activation involved in immune response (GO:0002283)4.76876760
15regulation of interferon-beta biosynthetic process (GO:0045357)4.75766718
16macrophage activation involved in immune response (GO:0002281)4.55521597
17T-helper 1 type immune response (GO:0042088)4.44624969
18microglial cell activation (GO:0001774)4.40448076
19regulation of gamma-delta T cell differentiation (GO:0045586)4.40249305
20response to host immune response (GO:0052572)4.39812921
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.39812921
22negative regulation of interleukin-17 production (GO:0032700)4.35562163
23detection of external biotic stimulus (GO:0098581)4.34133265
24B cell receptor signaling pathway (GO:0050853)4.29131583
25negative regulation of interleukin-12 production (GO:0032695)4.15882153
26detection of other organism (GO:0098543)4.13502442
27response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.02951218
28response to host (GO:0075136)4.02951218
29response to host defenses (GO:0052200)4.02951218
30positive regulation of type 2 immune response (GO:0002830)4.01949411
31negative regulation of T-helper cell differentiation (GO:0045623)3.92847936
32negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.92847936
33macrophage activation (GO:0042116)3.92831086
34positive regulation of interferon-beta production (GO:0032728)3.92149077
35regulation of dendritic cell antigen processing and presentation (GO:0002604)3.91682166
36cellular extravasation (GO:0045123)3.81096665
37regulation of B cell differentiation (GO:0045577)3.79702578
38regulation of regulatory T cell differentiation (GO:0045589)3.79459922
39regulation of interleukin-12 biosynthetic process (GO:0045075)3.79208760
40positive regulation of interferon-alpha production (GO:0032727)3.77341793
41detection of biotic stimulus (GO:0009595)3.75640332
42regulation of interferon-alpha production (GO:0032647)3.71017495
43neutrophil activation (GO:0042119)3.66410171
44purine deoxyribonucleotide catabolic process (GO:0009155)3.63224789
45response to muramyl dipeptide (GO:0032495)3.62885449
46histone H3-K36 demethylation (GO:0070544)3.61452679
47regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.58838718
48regulation of T-helper 2 cell differentiation (GO:0045628)3.57274853
49histamine secretion (GO:0001821)3.54658411
50negative regulation of T cell mediated immunity (GO:0002710)3.51454881
51detection of bacterium (GO:0016045)3.49873839
52interferon-gamma-mediated signaling pathway (GO:0060333)3.49762445
53leukotriene biosynthetic process (GO:0019370)3.47735879
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.45934685
55negative T cell selection (GO:0043383)3.45456729
56immunoglobulin mediated immune response (GO:0016064)3.44282477
57myeloid cell activation involved in immune response (GO:0002275)3.43852331
58positive regulation of macrophage cytokine production (GO:0060907)3.43718758
59negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.43368153
60positive regulation of granulocyte differentiation (GO:0030854)3.42675533
61regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.42437742
62regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.41711236
63regulation of memory T cell differentiation (GO:0043380)3.40997331
64negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.39645257
65negative regulation of cell killing (GO:0031342)3.39645257
66regulation of interleukin-17 production (GO:0032660)3.32848044
67granulocyte activation (GO:0036230)3.30629331
68nucleoside diphosphate catabolic process (GO:0009134)3.28896361
69negative thymic T cell selection (GO:0045060)3.28162117
70positive regulation of antigen processing and presentation (GO:0002579)3.28094672
71regulation of germinal center formation (GO:0002634)3.21044901
72regulation of interferon-beta production (GO:0032648)3.20918362
73B cell mediated immunity (GO:0019724)3.20871099
74positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.18101171
75regulation of interleukin-6 biosynthetic process (GO:0045408)3.17319261
76negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.16279031
77interferon-gamma secretion (GO:0072643)3.16228014
78positive T cell selection (GO:0043368)3.15754864
79positive thymic T cell selection (GO:0045059)3.15189750
80regulation of alpha-beta T cell proliferation (GO:0046640)3.11182003
81positive regulation of alpha-beta T cell proliferation (GO:0046641)3.10855157
82regulation of B cell mediated immunity (GO:0002712)3.07703302
83regulation of T-helper 1 cell differentiation (GO:0045625)3.06056450
84regulation of macrophage cytokine production (GO:0010935)3.05093870
85antigen processing and presentation of endogenous antigen (GO:0019883)3.04380951
86neutrophil mediated immunity (GO:0002446)2.97056309
87regulation of interleukin-12 production (GO:0032655)2.96626721
88positive regulation of B cell activation (GO:0050871)2.95487025
89leukotriene metabolic process (GO:0006691)2.95259731
90positive regulation of interleukin-12 production (GO:0032735)2.94014234
91histone H3-K4 trimethylation (GO:0080182)2.93832070
92negative regulation of lymphocyte mediated immunity (GO:0002707)2.93445397
93interferon-gamma production (GO:0032609)2.93422268
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93381374
95response to interferon-alpha (GO:0035455)2.93106089
96negative regulation of adaptive immune response (GO:0002820)2.89454473
97purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.88667028
98positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.84228886
99positive regulation of isotype switching (GO:0045830)2.83135024
100histamine transport (GO:0051608)2.81740341

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.97587532
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.91899836
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.82646798
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.41310780
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.14158303
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.01065998
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.93082354
8SCL_19346495_ChIP-Seq_HPC-7_Human2.91737410
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.88070246
10GATA1_22025678_ChIP-Seq_K562_Human2.78597470
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.78329509
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.74686555
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71220182
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.59382873
15MYB_26560356_Chip-Seq_TH2_Human2.44730855
16RUNX_20019798_ChIP-Seq_JUKART_Human2.43213185
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40576717
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31887449
19SPI1_23547873_ChIP-Seq_NB4_Human2.06896412
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04068117
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.03749755
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.98579769
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.94865990
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93715593
25SPI1_23127762_ChIP-Seq_K562_Human1.91736888
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90989197
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84260328
28GATA3_26560356_Chip-Seq_TH2_Human1.78694939
29VDR_24787735_ChIP-Seq_THP-1_Human1.76483207
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67405655
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.67352249
32MYB_26560356_Chip-Seq_TH1_Human1.66629022
33GATA3_27048872_Chip-Seq_THYMUS_Human1.64949003
34PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55350311
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.54138468
36GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51083977
37NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.49596917
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.45281748
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.44764451
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43076206
41TP53_16413492_ChIP-PET_HCT116_Human1.38309197
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37572959
43VDR_24763502_ChIP-Seq_THP-1_Human1.35159836
44SMRT_27268052_Chip-Seq_Bcells_Human1.31149704
45MAF_26560356_Chip-Seq_TH1_Human1.29050677
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28390220
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28390220
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.28258318
49VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.27919697
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26055687
51SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25457335
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24838430
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.22101932
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.21703046
55PU_27001747_Chip-Seq_BMDM_Mouse1.21046291
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19983232
57GATA1_19941826_ChIP-Seq_K562_Human1.19005277
58PRDM14_20953172_ChIP-Seq_ESCs_Human1.18413075
59ER_23166858_ChIP-Seq_MCF-7_Human1.18058566
60VDR_22108803_ChIP-Seq_LS180_Human1.14602947
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14560879
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14226625
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.13433728
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11180198
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08931500
66UTX_26944678_Chip-Seq_JUKART_Human1.08504260
67TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07252978
68KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.06778794
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.05253565
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01520063
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01119500
72GATA2_19941826_ChIP-Seq_K562_Human1.00932540
73AR_21572438_ChIP-Seq_LNCaP_Human1.00432736
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.00295860
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99729769
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99566643
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98916650
78EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97100825
79PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96282024
80OCT1_27270436_Chip-Seq_PROSTATE_Human0.96126398
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95080254
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94291820
83SALL4_22934838_ChIP-ChIP_CD34+_Human0.93527880
84SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92071869
85ERG_20517297_ChIP-Seq_VCAP_Human0.90121536
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89181862
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88857606
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88277655
89CBP_20019798_ChIP-Seq_JUKART_Human0.88277655
90SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87958220
91CMYC_18555785_Chip-Seq_ESCs_Mouse0.87741632
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87370439
93TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.86351248
94E2F1_18555785_Chip-Seq_ESCs_Mouse0.86157161
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85346195
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85033252
97CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83526723
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82446629
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82328859
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81772144

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.45986651
2MP0001835_abnormal_antigen_presentation4.44911014
3MP0003724_increased_susceptibility_to4.34923795
4MP0001800_abnormal_humoral_immune3.00064172
5MP0003436_decreased_susceptibility_to2.73775884
6MP0000685_abnormal_immune_system2.71264722
7MP0000569_abnormal_digit_pigmentation2.67016734
8MP0003656_abnormal_erythrocyte_physiolo2.59764760
9MP0002419_abnormal_innate_immunity2.55472732
10MP0002452_abnormal_antigen_presenting2.48119883
11MP0005000_abnormal_immune_tolerance2.46081411
12MP0002723_abnormal_immune_serum2.36335354
13MP0009785_altered_susceptibility_to2.33763455
14MP0001853_heart_inflammation2.28495899
15MP0003172_abnormal_lysosome_physiology2.26500985
16MP0005671_abnormal_response_to2.26367504
17MP0002148_abnormal_hypersensitivity_rea2.25596681
18MP0005387_immune_system_phenotype2.24509171
19MP0001790_abnormal_immune_system2.24509171
20MP0006082_CNS_inflammation2.19230855
21MP0002420_abnormal_adaptive_immunity2.15971795
22MP0001819_abnormal_immune_cell2.14453661
23MP0005025_abnormal_response_to2.10560528
24MP0002166_altered_tumor_susceptibility2.04915640
25MP0008260_abnormal_autophagy1.99764892
26MP0009764_decreased_sensitivity_to1.96003411
27MP0000015_abnormal_ear_pigmentation1.94864468
28MP0002396_abnormal_hematopoietic_system1.93893641
29MP0009278_abnormal_bone_marrow1.80037981
30MP0003183_abnormal_peptide_metabolism1.78954865
31MP0002398_abnormal_bone_marrow1.77629470
32MP0005409_darkened_coat_color1.76029982
33MP0004808_abnormal_hematopoietic_stem1.72282154
34MP0000716_abnormal_immune_system1.67956760
35MP0001545_abnormal_hematopoietic_system1.65154041
36MP0005397_hematopoietic_system_phenotyp1.65154041
37MP0005464_abnormal_platelet_physiology1.64223095
38MP0003763_abnormal_thymus_physiology1.64040136
39MP0005310_abnormal_salivary_gland1.61124774
40MP0002405_respiratory_system_inflammati1.59885294
41MP0004883_abnormal_blood_vessel1.58113503
42MP0003300_gastrointestinal_ulcer1.57883769
43MP0003646_muscle_fatigue1.53865920
44MP0000689_abnormal_spleen_morphology1.51822569
45MP0005174_abnormal_tail_pigmentation1.42592785
46MP0001533_abnormal_skeleton_physiology1.41133559
47MP0010155_abnormal_intestine_physiology1.40712597
48MP0002722_abnormal_immune_system1.38502897
49MP0002006_tumorigenesis1.36406462
50MP0002009_preneoplasia1.35424997
51MP0003806_abnormal_nucleotide_metabolis1.35314123
52MP0005164_abnormal_response_to1.33154789
53MP0001845_abnormal_inflammatory_respons1.30440089
54MP0004947_skin_inflammation1.29770830
55MP0002429_abnormal_blood_cell1.29101171
56MP0002332_abnormal_exercise_endurance1.26659047
57MP0003191_abnormal_cellular_cholesterol1.22305023
58MP0004381_abnormal_hair_follicle1.18134279
59MP0002132_abnormal_respiratory_system1.14733909
60MP0008469_abnormal_protein_level1.14340402
61MP0000371_diluted_coat_color1.13566338
62MP0008995_early_reproductive_senescence1.12357508
63MP0003045_fibrosis1.10695190
64MP0003828_pulmonary_edema1.07131624
65MP0000703_abnormal_thymus_morphology1.06260468
66MP0008057_abnormal_DNA_replication1.05520101
67MP0009765_abnormal_xenobiotic_induced1.05478758
68MP0002095_abnormal_skin_pigmentation1.01994721
69MP0008058_abnormal_DNA_repair1.01579970
70MP0003690_abnormal_glial_cell0.98972595
71MP0004130_abnormal_muscle_cell0.96296558
72MP0005075_abnormal_melanosome_morpholog0.93961373
73MP0000372_irregular_coat_pigmentation0.92625035
74MP0003075_altered_response_to0.88375387
75MP0002277_abnormal_respiratory_mucosa0.87375999
76MP0009115_abnormal_fat_cell0.86234229
77MP0001663_abnormal_digestive_system0.86157745
78MP0003866_abnormal_defecation0.84484858
79MP0008961_abnormal_basal_metabolism0.84195906
80MP0000858_altered_metastatic_potential0.83261655
81MP0005376_homeostasis/metabolism_phenot0.79187078
82MP0002998_abnormal_bone_remodeling0.78413884
83MP0009763_increased_sensitivity_to0.77402936
84MP0008004_abnormal_stomach_pH0.76233203
85MP0004043_abnormal_pH_regulation0.73155171
86MP0000249_abnormal_blood_vessel0.71465269
87MP0005408_hypopigmentation0.69436300
88MP0004484_altered_response_of0.69352974
89MP0005171_absent_coat_pigmentation0.69201723
90MP0002019_abnormal_tumor_incidence0.68223854
91MP0004147_increased_porphyrin_level0.67451630
92MP0001851_eye_inflammation0.64849782
93MP0005166_decreased_susceptibility_to0.64725010
94MP0005646_abnormal_pituitary_gland0.64590021
95MP0005451_abnormal_body_composition0.62144599
96MP0005334_abnormal_fat_pad0.60598865
97MP0002138_abnormal_hepatobiliary_system0.56235166
98MP0000465_gastrointestinal_hemorrhage0.55965056
99MP0005266_abnormal_metabolism0.55691666
100MP0005535_abnormal_body_temperature0.55555670

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.73243176
2Panhypogammaglobulinemia (HP:0003139)5.62772326
3Recurrent abscess formation (HP:0002722)4.84576462
4Optic neuritis (HP:0100653)4.73862731
5Retrobulbar optic neuritis (HP:0100654)4.73862731
6Chronic otitis media (HP:0000389)4.61099470
7Orchitis (HP:0100796)4.47222961
8Myositis (HP:0100614)4.36658549
9Increased neuronal autofluorescent lipopigment (HP:0002074)4.30418200
10Gastrointestinal infarctions (HP:0005244)4.22822811
11Recurrent cutaneous fungal infections (HP:0011370)4.18912902
12Chronic mucocutaneous candidiasis (HP:0002728)4.18912902
13Recurrent skin infections (HP:0001581)4.15279898
14Agammaglobulinemia (HP:0004432)4.12424662
15Encephalitis (HP:0002383)4.04767232
16Increased cerebral lipofuscin (HP:0011813)3.93003472
17Viral hepatitis (HP:0006562)3.92234401
18Elevated erythrocyte sedimentation rate (HP:0003565)3.78609362
19Abnormality of the prostate (HP:0008775)3.78217918
20Recurrent viral infections (HP:0004429)3.76731916
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.75719885
22Meningitis (HP:0001287)3.70138962
23Arterial thrombosis (HP:0004420)3.61839937
24Recurrent fungal infections (HP:0002841)3.49316229
25Chest pain (HP:0100749)3.41158762
26Keratoconjunctivitis sicca (HP:0001097)3.34233151
27Gingival bleeding (HP:0000225)3.27948568
28Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.23995924
29Hemoptysis (HP:0002105)3.20060445
30Pulmonary infiltrates (HP:0002113)3.19095051
31Keratoconjunctivitis (HP:0001096)3.13751834
32Eczematoid dermatitis (HP:0000976)3.04647289
33Vasculitis (HP:0002633)3.03883481
34Gangrene (HP:0100758)2.96806228
35T lymphocytopenia (HP:0005403)2.93233407
36Abnormality of T cell number (HP:0011839)2.91452880
37Peritonitis (HP:0002586)2.71139188
38Stomatitis (HP:0010280)2.69867214
39Abnormality of the right ventricle (HP:0001707)2.68623872
40Abnormality of glycolipid metabolism (HP:0010969)2.63543403
41Abnormality of liposaccharide metabolism (HP:0010968)2.63543403
42Abnormality of glycosphingolipid metabolism (HP:0004343)2.63543403
43Amaurosis fugax (HP:0100576)2.61264143
44Epistaxis (HP:0000421)2.59084555
45Pulmonary embolism (HP:0002204)2.56633415
46Cellulitis (HP:0100658)2.52374264
47Tinnitus (HP:0000360)2.51296657
48Colitis (HP:0002583)2.48809407
49Abnormality of T cells (HP:0002843)2.45685102
50Mediastinal lymphadenopathy (HP:0100721)2.44017210
51Chronic obstructive pulmonary disease (HP:0006510)2.42544052
52Obstructive lung disease (HP:0006536)2.42544052
53Thrombophlebitis (HP:0004418)2.37545776
54Urethral obstruction (HP:0000796)2.36056852
55Abnormality of T cell physiology (HP:0011840)2.34515456
56Anorexia (HP:0002039)2.32221890
57Abnormality of male internal genitalia (HP:0000022)2.29752473
58Gingivitis (HP:0000230)2.27994690
59Clumsiness (HP:0002312)2.27248131
60Abnormality of the fingertips (HP:0001211)2.27084615
61Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.26253524
62Genetic anticipation (HP:0003743)2.24624842
63Abolished electroretinogram (ERG) (HP:0000550)2.24365418
64Acute hepatic failure (HP:0006554)2.21720727
65Spontaneous hematomas (HP:0007420)2.19936613
66Inflammation of the large intestine (HP:0002037)2.19790008
67Abnormality of the pleura (HP:0002103)2.19416237
68Vertigo (HP:0002321)2.19381907
69Osteomyelitis (HP:0002754)2.12080210
70Prolonged bleeding time (HP:0003010)2.09285941
71Tubulointerstitial nephritis (HP:0001970)2.09012307
72Recurrent gram-negative bacterial infections (HP:0005420)2.08161680
73Autoimmune thrombocytopenia (HP:0001973)2.05890817
74Diplopia (HP:0000651)2.04961759
75Abnormality of binocular vision (HP:0011514)2.04961759
76Acute myeloid leukemia (HP:0004808)2.04441924
77Urticaria (HP:0001025)2.02516693
78Xerostomia (HP:0000217)2.00862561
79Interstitial pulmonary disease (HP:0006530)2.00787107
80Spontaneous abortion (HP:0005268)1.99659330
81Abnormality of macrophages (HP:0004311)1.99407345
82Recurrent bronchitis (HP:0002837)1.98902564
83Abnormality of the peritoneum (HP:0002585)1.98309974
84Leukocytosis (HP:0001974)1.97708528
85Ureteral obstruction (HP:0006000)1.97687538
86Skin rash (HP:0000988)1.96573606
87Thrombocytosis (HP:0001894)1.95668579
88Postural instability (HP:0002172)1.95126111
89Gastrointestinal inflammation (HP:0004386)1.94712548
90Abnormality of the heme biosynthetic pathway (HP:0010472)1.89252836
91Gaze-evoked nystagmus (HP:0000640)1.86055820
92Abnormality of the vasculature of the conjunctiva (HP:0008054)1.84837974
93Poikilocytosis (HP:0004447)1.84726878
94Thickened calvaria (HP:0002684)1.84535951
95Polyneuropathy (HP:0001271)1.84147914
96Glomerulopathy (HP:0100820)1.83302385
97Hepatitis (HP:0012115)1.79280288
98Keratitis (HP:0000491)1.78756035
99Amyloidosis (HP:0011034)1.76720177
100Portal hypertension (HP:0001409)1.74797576

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.09066705
2TEC3.35008604
3BCKDK3.06356114
4ITK2.81067161
5BLK2.72382535
6IRAK42.61671863
7TAOK32.58905370
8MAP4K12.57411978
9BTK2.23317972
10SYK2.19403226
11TXK2.14764505
12IKBKE2.01562382
13IRAK11.96074203
14CAMK1D1.95002980
15BRD41.90787568
16FES1.87342965
17MAPKAPK31.81886859
18BMPR21.80385069
19MAP2K31.74644187
20FRK1.71665045
21CSK1.60415972
22WNK11.58432983
23PIK3CG1.57858644
24TBK11.56971083
25TYK21.53438132
26IRAK21.51701075
27JAK31.38849833
28ZAP701.37201131
29KIT1.35874683
30TNK21.35508230
31LYN1.33839218
32MAP3K141.33370739
33AKT31.32885083
34JAK11.29782439
35HCK1.27428206
36FGR1.24900604
37IKBKB1.22218799
38CAMK1G1.17370554
39SGK21.16730520
40YES11.16257230
41MARK31.13986748
42CDK121.13813817
43ACVR1B1.11578110
44JAK21.09351759
45MAP3K131.08000639
46MAP3K111.06178081
47CAMKK11.05776780
48MATK1.03971378
49LCK1.00918301
50GRK60.99678482
51CHUK0.97251620
52CAMKK20.96180642
53CLK10.94480432
54MAP3K10.92880561
55SGK30.92445643
56FGFR30.91991147
57IRAK30.87558352
58TRPM70.87142316
59CSF1R0.87141360
60TLK10.75475137
61MAPK70.75297226
62ABL10.74662293
63CDC42BPA0.74373314
64PRKAA20.70770439
65PIM10.70138068
66ERN10.69902350
67GRK70.69409797
68EPHB10.69046374
69MELK0.68044133
70SGK4940.67158486
71SGK2230.67158486
72MAP3K20.64505320
73CCNB10.61745698
74MAP3K50.60491921
75PTK2B0.58651634
76SGK10.55923960
77EPHA30.53970889
78CDK30.52826841
79PRPF4B0.51960253
80PRKCQ0.50892119
81EGFR0.50183306
82CDK60.49862204
83MAPKAPK20.49813691
84CAMK40.48785091
85IGF1R0.48747665
86MAP2K60.47220571
87PDK10.45313328
88MAP3K60.44839811
89HIPK20.41623681
90PIK3CA0.41100735
91STK40.40747934
92MARK20.38333352
93MAPK130.38003436
94PDPK10.37304504
95CDK190.36779533
96FYN0.36714917
97STK100.36636104
98NLK0.36104503
99ABL20.35723838
100FGFR40.31456574

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.66567342
2Leishmaniasis_Homo sapiens_hsa051403.35081213
3Allograft rejection_Homo sapiens_hsa053303.28364322
4Graft-versus-host disease_Homo sapiens_hsa053323.15967619
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.12625687
6Autoimmune thyroid disease_Homo sapiens_hsa053203.09081505
7Staphylococcus aureus infection_Homo sapiens_hsa051502.97407870
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.75036858
9Type I diabetes mellitus_Homo sapiens_hsa049402.44062462
10Tuberculosis_Homo sapiens_hsa051522.20239759
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.16963643
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.16453253
13Osteoclast differentiation_Homo sapiens_hsa043802.11528107
14Antigen processing and presentation_Homo sapiens_hsa046122.00496862
15Primary immunodeficiency_Homo sapiens_hsa053402.00360467
16Influenza A_Homo sapiens_hsa051641.98807652
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98016440
18B cell receptor signaling pathway_Homo sapiens_hsa046621.95877378
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74113604
20Toxoplasmosis_Homo sapiens_hsa051451.73379710
21Viral myocarditis_Homo sapiens_hsa054161.73019861
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.66861463
23Hematopoietic cell lineage_Homo sapiens_hsa046401.65517459
24Herpes simplex infection_Homo sapiens_hsa051681.62484282
25Measles_Homo sapiens_hsa051621.61734461
26Malaria_Homo sapiens_hsa051441.58503127
27Rheumatoid arthritis_Homo sapiens_hsa053231.57973970
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43900735
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43351407
30Hepatitis C_Homo sapiens_hsa051601.33853831
31Legionellosis_Homo sapiens_hsa051341.30221024
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.29385670
33TNF signaling pathway_Homo sapiens_hsa046681.26556501
34T cell receptor signaling pathway_Homo sapiens_hsa046601.10383826
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04915262
36Chemokine signaling pathway_Homo sapiens_hsa040621.00229610
37Adipocytokine signaling pathway_Homo sapiens_hsa049200.93304075
38Hepatitis B_Homo sapiens_hsa051610.92237164
39Non-small cell lung cancer_Homo sapiens_hsa052230.89352505
40Dorso-ventral axis formation_Homo sapiens_hsa043200.89063371
41Epstein-Barr virus infection_Homo sapiens_hsa051690.88936008
42Platelet activation_Homo sapiens_hsa046110.88851826
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84578737
44Prolactin signaling pathway_Homo sapiens_hsa049170.84148574
45Acute myeloid leukemia_Homo sapiens_hsa052210.82290229
46African trypanosomiasis_Homo sapiens_hsa051430.81233766
47Phagosome_Homo sapiens_hsa041450.81216357
48Pancreatic cancer_Homo sapiens_hsa052120.79216721
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79033506
50FoxO signaling pathway_Homo sapiens_hsa040680.78170942
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73642292
52Pertussis_Homo sapiens_hsa051330.71820306
53Other glycan degradation_Homo sapiens_hsa005110.68141962
54Systemic lupus erythematosus_Homo sapiens_hsa053220.64401960
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63648809
56Shigellosis_Homo sapiens_hsa051310.61007882
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59516188
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55423648
59Insulin resistance_Homo sapiens_hsa049310.54510983
60ABC transporters_Homo sapiens_hsa020100.54495638
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50090228
62Fatty acid biosynthesis_Homo sapiens_hsa000610.49161754
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.48763048
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45526199
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45120553
66RNA polymerase_Homo sapiens_hsa030200.43881906
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.42550145
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40841263
69Taste transduction_Homo sapiens_hsa047420.38936969
70Chronic myeloid leukemia_Homo sapiens_hsa052200.38669726
71Lysine degradation_Homo sapiens_hsa003100.38341698
72mTOR signaling pathway_Homo sapiens_hsa041500.37778938
73Inositol phosphate metabolism_Homo sapiens_hsa005620.34733512
74Apoptosis_Homo sapiens_hsa042100.34373500
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34065084
76Viral carcinogenesis_Homo sapiens_hsa052030.33096769
77Lysosome_Homo sapiens_hsa041420.32000193
78VEGF signaling pathway_Homo sapiens_hsa043700.31409005
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29592340
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.29201304
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28555210
82GnRH signaling pathway_Homo sapiens_hsa049120.27367047
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26808148
84HIF-1 signaling pathway_Homo sapiens_hsa040660.25560386
85ErbB signaling pathway_Homo sapiens_hsa040120.23708270
86Salmonella infection_Homo sapiens_hsa051320.23349157
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22521066
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21886583
89Type II diabetes mellitus_Homo sapiens_hsa049300.21763296
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21433271
91PPAR signaling pathway_Homo sapiens_hsa033200.20694193
92MAPK signaling pathway_Homo sapiens_hsa040100.19950658
93Peroxisome_Homo sapiens_hsa041460.19932574
94RNA degradation_Homo sapiens_hsa030180.19930992
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19637071
96HTLV-I infection_Homo sapiens_hsa051660.19628331
97Oxytocin signaling pathway_Homo sapiens_hsa049210.18846325
98Cholinergic synapse_Homo sapiens_hsa047250.18667096
99Choline metabolism in cancer_Homo sapiens_hsa052310.18162203
100Ovarian steroidogenesis_Homo sapiens_hsa049130.16843301

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