MTND5P16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of neuron projection regeneration (GO:0070570)7.25825355
2regulation of axon regeneration (GO:0048679)7.25825355
3urinary tract smooth muscle contraction (GO:0014848)6.97084308
4substrate-independent telencephalic tangential migration (GO:0021826)6.59869049
5substrate-independent telencephalic tangential interneuron migration (GO:0021843)6.59869049
6membrane depolarization during cardiac muscle cell action potential (GO:0086012)6.25462353
7N-glycan processing (GO:0006491)5.95600100
8atrial cardiac muscle cell action potential (GO:0086014)5.47535065
9regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.28462226
10epithelial cell fate commitment (GO:0072148)5.00532526
11negative regulation of astrocyte differentiation (GO:0048712)4.93340451
12nephron tubule morphogenesis (GO:0072078)4.91629405
13nephron epithelium morphogenesis (GO:0072088)4.91629405
14cell proliferation in forebrain (GO:0021846)4.72410696
15membrane depolarization during action potential (GO:0086010)4.70446762
16positive regulation of actin cytoskeleton reorganization (GO:2000251)4.56261909
17growth hormone secretion (GO:0030252)4.48821667
18lens fiber cell differentiation (GO:0070306)4.48099655
19modulation by virus of host process (GO:0019054)4.39061475
20negative regulation of glycogen biosynthetic process (GO:0045719)4.33502195
21negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.26948726
22negative regulation of translation, ncRNA-mediated (GO:0040033)4.26948726
23regulation of translation, ncRNA-mediated (GO:0045974)4.26948726
24cochlea development (GO:0090102)4.23629225
25renal tubule morphogenesis (GO:0061333)3.92489585
26ether lipid metabolic process (GO:0046485)3.84252619
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.77435150
28behavioral response to nicotine (GO:0035095)3.63178107
29fucose catabolic process (GO:0019317)3.62260131
30L-fucose metabolic process (GO:0042354)3.62260131
31L-fucose catabolic process (GO:0042355)3.62260131
32regulation of nuclear cell cycle DNA replication (GO:0033262)3.58686584
33activation of protein kinase B activity (GO:0032148)3.57482117
34positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.55976445
35sequestering of extracellular ligand from receptor (GO:0035581)3.53599706
36cell communication involved in cardiac conduction (GO:0086065)3.48071394
37negative regulation of glycogen metabolic process (GO:0070874)3.42833201
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.41279954
39positive regulation of cardiac muscle cell differentiation (GO:2000727)3.39839897
40startle response (GO:0001964)3.35213813
41negative regulation of activin receptor signaling pathway (GO:0032926)3.24435337
42glutamate receptor signaling pathway (GO:0007215)3.20531193
43pyrimidine nucleobase catabolic process (GO:0006208)3.20014200
44negative regulation of telomere maintenance (GO:0032205)3.14900020
45mechanoreceptor differentiation (GO:0042490)3.11449614
46glutamate secretion (GO:0014047)3.08648428
47protein localization to cilium (GO:0061512)3.08122022
48modulation by symbiont of host cellular process (GO:0044068)3.07602138
49regulation of heart rate by cardiac conduction (GO:0086091)3.06258832
50cell communication by electrical coupling (GO:0010644)3.04176679
51interleukin-6-mediated signaling pathway (GO:0070102)3.03231093
52cellular ketone body metabolic process (GO:0046950)3.02025229
53purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.00520061
543-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.00520061
55phospholipid dephosphorylation (GO:0046839)3.00019638
56positive regulation of synapse assembly (GO:0051965)2.95992664
57phosphatidylinositol dephosphorylation (GO:0046856)2.95405349
58detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.95255502
59regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.94605689
60neuron fate specification (GO:0048665)2.92242124
61regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.91172523
62adult walking behavior (GO:0007628)2.91016745
63cornea development in camera-type eye (GO:0061303)2.90605414
64negative regulation of protein autophosphorylation (GO:0031953)2.90379536
65calcium ion import (GO:0070509)2.89495135
66telomere maintenance via telomerase (GO:0007004)2.87700344
67regulation of posttranscriptional gene silencing (GO:0060147)2.87170428
68regulation of gene silencing by miRNA (GO:0060964)2.87170428
69regulation of gene silencing by RNA (GO:0060966)2.87170428
70single strand break repair (GO:0000012)2.86259749
71negative regulation of synaptic transmission, GABAergic (GO:0032229)2.85485635
72positive regulation of axon extension (GO:0045773)2.76753448
73regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.74831672
74base-excision repair, AP site formation (GO:0006285)2.74630006
75postsynaptic membrane organization (GO:0001941)2.72484669
76presynaptic membrane assembly (GO:0097105)2.71862282
77sulfation (GO:0051923)2.71719886
78positive regulation of neurological system process (GO:0031646)2.70019257
79nucleobase catabolic process (GO:0046113)2.68877606
80neuron maturation (GO:0042551)2.68817373
81regulation of mesoderm development (GO:2000380)2.67840985
82calcium ion-dependent exocytosis (GO:0017156)2.67275136
83gamma-aminobutyric acid signaling pathway (GO:0007214)2.66963744
84action potential (GO:0001508)2.66745058
85synaptic transmission, glutamatergic (GO:0035249)2.65548951
86ketone body metabolic process (GO:1902224)2.63787575
87regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.62410492
88cerebral cortex cell migration (GO:0021795)2.61711836
89positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.60103757
90cell migration involved in gastrulation (GO:0042074)2.58271552
91response to corticosterone (GO:0051412)2.57777898
92negative regulation of DNA-dependent DNA replication (GO:2000104)2.56051576
93presynaptic membrane organization (GO:0097090)2.55953878
94positive regulation of heart rate (GO:0010460)2.55290424
95serotonin receptor signaling pathway (GO:0007210)2.53764554
96smooth muscle contraction (GO:0006939)2.53563034
97respiratory chain complex IV assembly (GO:0008535)2.52930901
98negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.51274952
99cellular anion homeostasis (GO:0030002)2.50283908
100cardiac conduction (GO:0061337)2.49791685

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.18905576
2GBX2_23144817_ChIP-Seq_PC3_Human3.72785999
3VDR_22108803_ChIP-Seq_LS180_Human3.51451092
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.21238652
5ZNF274_21170338_ChIP-Seq_K562_Hela3.20428648
6ZFP57_27257070_Chip-Seq_ESCs_Mouse3.11585280
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.01467494
8TAF15_26573619_Chip-Seq_HEK293_Human2.52994227
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.50834549
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.38922654
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27047712
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18677101
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17229895
14P300_19829295_ChIP-Seq_ESCs_Human2.16528740
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11721149
16PIAS1_25552417_ChIP-Seq_VCAP_Human2.07903219
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01348347
18FUS_26573619_Chip-Seq_HEK293_Human2.00045534
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91898538
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.91835736
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90398313
22AR_21572438_ChIP-Seq_LNCaP_Human1.88534273
23TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86870407
24POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.86870407
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.84663287
26SMAD4_21799915_ChIP-Seq_A2780_Human1.82244284
27REST_21632747_ChIP-Seq_MESCs_Mouse1.69034901
28NR3C1_21868756_ChIP-Seq_MCF10A_Human1.63441856
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60866940
30EWS_26573619_Chip-Seq_HEK293_Human1.59636817
31ER_23166858_ChIP-Seq_MCF-7_Human1.59267686
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58735251
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53999475
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53900040
35STAT3_23295773_ChIP-Seq_U87_Human1.50661098
36TCF4_23295773_ChIP-Seq_U87_Human1.49573946
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42165643
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40906648
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.40474972
40BCAT_22108803_ChIP-Seq_LS180_Human1.37488649
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.35072186
42FLI1_21867929_ChIP-Seq_TH2_Mouse1.32337894
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.30340129
44TCF4_22108803_ChIP-Seq_LS180_Human1.30276389
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29343462
46AR_25329375_ChIP-Seq_VCAP_Human1.28573217
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.27980889
48TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.27506809
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26647907
50SMAD3_21741376_ChIP-Seq_ESCs_Human1.25651913
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25338168
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24036292
53NANOG_19829295_ChIP-Seq_ESCs_Human1.22500040
54SOX2_19829295_ChIP-Seq_ESCs_Human1.22500040
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21212380
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19220799
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18479559
58DROSHA_22980978_ChIP-Seq_HELA_Human1.17868923
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17837963
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17329506
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.16393975
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15894893
63FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15861478
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15791802
65RUNX2_22187159_ChIP-Seq_PCA_Human1.14828640
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11878070
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11665897
68KDM2B_26808549_Chip-Seq_REH_Human1.11558129
69TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11557714
70TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11385949
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.10446398
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.10232759
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07939571
74CBP_20019798_ChIP-Seq_JUKART_Human1.07939571
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07928860
76TP53_22573176_ChIP-Seq_HFKS_Human1.07769627
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.07284594
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06280047
79JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05934324
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05733651
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.04994359
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04949215
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.04880927
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04880927
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.03720157
86RNF2_27304074_Chip-Seq_NSC_Mouse1.03643819
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03105810
88ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02817127
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01600685
90EZH2_27304074_Chip-Seq_ESCs_Mouse1.01370253
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00268421
92IGF1R_20145208_ChIP-Seq_DFB_Human0.99832963
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99826911
94SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99763412
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.99628491
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.99608221
97NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99476718
98NANOG_18555785_Chip-Seq_ESCs_Mouse0.99274037
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.98749765
100SMAD4_21741376_ChIP-Seq_EPCs_Human0.98532973

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism6.24478167
2MP0003195_calcinosis4.51206416
3MP0006054_spinal_hemorrhage3.80677979
4MP0002735_abnormal_chemical_nociception3.47207207
5MP0009046_muscle_twitch3.43201720
6MP0003890_abnormal_embryonic-extraembry2.94543350
7MP0006072_abnormal_retinal_apoptosis2.91859785
8MP0003880_abnormal_central_pattern2.79599839
9MP0008877_abnormal_DNA_methylation2.77591871
10MP0010030_abnormal_orbit_morphology2.73399292
11MP0004215_abnormal_myocardial_fiber2.24525755
12MP0009745_abnormal_behavioral_response2.24400924
13MP0002572_abnormal_emotion/affect_behav2.20224516
14MP0004885_abnormal_endolymph2.14852271
15MP0004270_analgesia2.10494593
16MP0004142_abnormal_muscle_tone2.04645498
17MP0002067_abnormal_sensory_capabilities2.01342675
18MP0004147_increased_porphyrin_level1.97410480
19MP0002272_abnormal_nervous_system1.95016307
20MP0001188_hyperpigmentation1.94453440
21MP0002064_seizures1.92278364
22MP0002938_white_spotting1.92021499
23MP0003787_abnormal_imprinting1.89808186
24MP0005551_abnormal_eye_electrophysiolog1.86050310
25MP0003635_abnormal_synaptic_transmissio1.82512291
26MP0003283_abnormal_digestive_organ1.80787361
27MP0002733_abnormal_thermal_nociception1.79967615
28MP0005253_abnormal_eye_physiology1.78742245
29MP0003950_abnormal_plasma_membrane1.70811771
30MP0001970_abnormal_pain_threshold1.66584763
31MP0002063_abnormal_learning/memory/cond1.64559151
32MP0002909_abnormal_adrenal_gland1.61758470
33MP0001486_abnormal_startle_reflex1.59416105
34MP0001968_abnormal_touch/_nociception1.56404869
35MP0002295_abnormal_pulmonary_circulatio1.54872676
36MP0001485_abnormal_pinna_reflex1.54215324
37MP0005083_abnormal_biliary_tract1.52337839
38MP0002557_abnormal_social/conspecific_i1.49866340
39MP0002736_abnormal_nociception_after1.45766988
40MP0003633_abnormal_nervous_system1.44597582
41MP0002734_abnormal_mechanical_nocicepti1.43381419
42MP0002184_abnormal_innervation1.40190783
43MP0001501_abnormal_sleep_pattern1.40019964
44MP0004924_abnormal_behavior1.39734113
45MP0005386_behavior/neurological_phenoty1.39734113
46MP0004859_abnormal_synaptic_plasticity1.38424034
47MP0003121_genomic_imprinting1.37325871
48MP0005645_abnormal_hypothalamus_physiol1.29462631
49MP0001986_abnormal_taste_sensitivity1.28220387
50MP0005423_abnormal_somatic_nervous1.24377403
51MP0008872_abnormal_physiological_respon1.24279794
52MP0003567_abnormal_fetal_cardiomyocyte1.17353537
53MP0001905_abnormal_dopamine_level1.16677107
54MP0002102_abnormal_ear_morphology1.16438965
55MP0004742_abnormal_vestibular_system1.09425494
56MP0003631_nervous_system_phenotype1.07971002
57MP0004133_heterotaxia1.06939357
58MP0003011_delayed_dark_adaptation1.05245223
59MP0000427_abnormal_hair_cycle1.00416602
60MP0000579_abnormal_nail_morphology0.98707975
61MP0008057_abnormal_DNA_replication0.91579857
62MP0003122_maternal_imprinting0.91093699
63MP0001502_abnormal_circadian_rhythm0.88835846
64MP0002066_abnormal_motor_capabilities/c0.88150533
65MP0002882_abnormal_neuron_morphology0.88129520
66MP0004145_abnormal_muscle_electrophysio0.87983184
67MP0002752_abnormal_somatic_nervous0.87730386
68MP0001440_abnormal_grooming_behavior0.86035696
69MP0006276_abnormal_autonomic_nervous0.83068918
70MP0002751_abnormal_autonomic_nervous0.82980921
71MP0004043_abnormal_pH_regulation0.82101670
72MP0003137_abnormal_impulse_conducting0.79301436
73MP0000026_abnormal_inner_ear0.79163273
74MP0000778_abnormal_nervous_system0.76499721
75MP0005195_abnormal_posterior_eye0.76350115
76MP0002822_catalepsy0.74824436
77MP0002229_neurodegeneration0.73442968
78MP0002254_reproductive_system_inflammat0.72932814
79MP0003941_abnormal_skin_development0.72739403
80MP0001529_abnormal_vocalization0.71637038
81MP0005367_renal/urinary_system_phenotyp0.69798602
82MP0000516_abnormal_urinary_system0.69798602
83MP0005503_abnormal_tendon_morphology0.69664367
84MP0002234_abnormal_pharynx_morphology0.67772198
85MP0004484_altered_response_of0.67596993
86MP0004085_abnormal_heartbeat0.66934287
87MP0005084_abnormal_gallbladder_morpholo0.66291911
88MP0001944_abnormal_pancreas_morphology0.65846656
89MP0008995_early_reproductive_senescence0.65364679
90MP0001873_stomach_inflammation0.64190325
91MP0001963_abnormal_hearing_physiology0.64142065
92MP0003123_paternal_imprinting0.63143342
93MP0010386_abnormal_urinary_bladder0.62900054
94MP0008770_decreased_survivor_rate0.59700381
95MP0001984_abnormal_olfaction0.58640762
96MP0005410_abnormal_fertilization0.57639293
97MP0004084_abnormal_cardiac_muscle0.57513696
98MP0002152_abnormal_brain_morphology0.56573937
99MP0000767_abnormal_smooth_muscle0.55872542
100MP0004811_abnormal_neuron_physiology0.54411306

Predicted human phenotypes

RankGene SetZ-score
1Flat capital femoral epiphysis (HP:0003370)5.96069927
2Limb dystonia (HP:0002451)5.79024783
3Abnormality of glycolipid metabolism (HP:0010969)4.59993799
4Abnormality of liposaccharide metabolism (HP:0010968)4.59993799
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.59993799
6Large eyes (HP:0001090)4.47848873
7Absent/shortened dynein arms (HP:0200106)4.06853291
8Dynein arm defect of respiratory motile cilia (HP:0012255)4.06853291
9Dyschromatopsia (HP:0007641)3.96858658
10Genetic anticipation (HP:0003743)3.92525830
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.92109214
12Focal motor seizures (HP:0011153)3.87900540
13Abolished electroretinogram (ERG) (HP:0000550)3.75273148
14Broad alveolar ridges (HP:0000187)3.75015633
15Increased corneal curvature (HP:0100692)3.72292401
16Keratoconus (HP:0000563)3.72292401
17Lissencephaly (HP:0001339)3.59907178
18Overlapping toe (HP:0001845)3.55935301
19Overriding aorta (HP:0002623)3.49095476
20Elfin facies (HP:0004428)3.46785057
21Type II lissencephaly (HP:0007260)3.46559420
22Progressive cerebellar ataxia (HP:0002073)3.30984472
23Vitreoretinal degeneration (HP:0000655)3.26130323
24Generalized myoclonic seizures (HP:0002123)3.20544500
25Renovascular hypertension (HP:0100817)3.17084727
26Stomach cancer (HP:0012126)3.12353333
27Retinal dysplasia (HP:0007973)3.04101336
28Flared iliac wings (HP:0002869)2.98107876
29Gaze-evoked nystagmus (HP:0000640)2.95044717
30Flat cornea (HP:0007720)2.91140673
31Renal duplication (HP:0000075)2.88067349
32Hyperacusis (HP:0010780)2.85026432
33Abnormal rod and cone electroretinograms (HP:0008323)2.84089271
34Abnormality of midbrain morphology (HP:0002418)2.75315460
35Molar tooth sign on MRI (HP:0002419)2.75315460
36Abnormal EKG (HP:0003115)2.66527646
37Colon cancer (HP:0003003)2.57408006
38Hyperventilation (HP:0002883)2.54071288
39Rhinitis (HP:0012384)2.51577646
40Syncope (HP:0001279)2.50084798
41Pigmentary retinal degeneration (HP:0001146)2.46533886
42Focal seizures (HP:0007359)2.45989397
43Pachygyria (HP:0001302)2.44329237
44Dialeptic seizures (HP:0011146)2.41780165
45Tetraplegia (HP:0002445)2.40603160
46Dysmetric saccades (HP:0000641)2.38820302
47Absence seizures (HP:0002121)2.37938586
48Protruding tongue (HP:0010808)2.37452451
49Abnormality of the diencephalon (HP:0010662)2.36278158
50Atonic seizures (HP:0010819)2.35872513
51Prolonged QT interval (HP:0001657)2.33017097
52Chronic bronchitis (HP:0004469)2.32569814
53Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.31579271
54Chronic otitis media (HP:0000389)2.29375631
55Aortic valve stenosis (HP:0001650)2.26296246
56Abnormal respiratory motile cilium physiology (HP:0012261)2.25904482
57Febrile seizures (HP:0002373)2.25851033
58Cerebellar dysplasia (HP:0007033)2.24412523
59Insomnia (HP:0100785)2.20716521
60Large for gestational age (HP:0001520)2.16822800
61Widely spaced teeth (HP:0000687)2.14125364
62Primary atrial arrhythmia (HP:0001692)2.12863066
63Epileptiform EEG discharges (HP:0011182)2.12836017
64Renal dysplasia (HP:0000110)2.12373181
65Aplasia/Hypoplasia of the tibia (HP:0005772)2.12333825
66EEG with generalized epileptiform discharges (HP:0011198)2.10830782
67Sudden death (HP:0001699)2.10752112
68Hemiparesis (HP:0001269)2.09835469
69Vascular calcification (HP:0004934)2.08876383
70Prominent supraorbital ridges (HP:0000336)2.06878489
71Urinary bladder sphincter dysfunction (HP:0002839)2.04622877
72Abnormality of the renal cortex (HP:0011035)2.04401113
73Abnormal respiratory motile cilium morphology (HP:0005938)2.03244080
74Abnormal respiratory epithelium morphology (HP:0012253)2.03244080
75Hypsarrhythmia (HP:0002521)2.01411059
76Macular degeneration (HP:0000608)2.00463523
77Small hand (HP:0200055)1.97699399
78Agitation (HP:0000713)1.97345620
79Spastic tetraplegia (HP:0002510)1.97006357
80Supraventricular tachycardia (HP:0004755)1.96988976
81Abnormality of binocular vision (HP:0011514)1.94310978
82Diplopia (HP:0000651)1.94310978
83Intellectual disability, progressive (HP:0006887)1.91741181
84Increased neuronal autofluorescent lipopigment (HP:0002074)1.91155829
85Severe global developmental delay (HP:0011344)1.90587599
86Abnormality of the epiphysis of the femoral head (HP:0010574)1.89369821
87Supraventricular arrhythmia (HP:0005115)1.88749439
88Abnormality of the renal medulla (HP:0100957)1.88381945
89Patellar aplasia (HP:0006443)1.86966232
90Nephronophthisis (HP:0000090)1.86296226
91Postural instability (HP:0002172)1.85023290
92Abnormality of the labia minora (HP:0012880)1.84521844
93Cardiovascular calcification (HP:0011915)1.82060181
94Abnormal ciliary motility (HP:0012262)1.81609140
95Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80513053
96Increased nuchal translucency (HP:0010880)1.78431536
97Aplasia/Hypoplasia of the patella (HP:0006498)1.78169138
98Impaired smooth pursuit (HP:0007772)1.77669780
99Abnormality of the alveolar ridges (HP:0006477)1.74579062
100Hyperaldosteronism (HP:0000859)1.74309287

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK38.97780550
2TAF15.08610232
3TIE13.30894227
4CASK3.23893939
5BMPR1B3.08920520
6MARK12.76575900
7TNIK2.64623337
8MAPK132.45179821
9FRK2.29707004
10PLK41.75103617
11STK381.70368101
12NTRK21.67278048
13TLK11.66724213
14PAK31.57251518
15PLK21.51568244
16WNK31.50830033
17EPHA41.47828132
18ZAK1.46624208
19STK161.38220432
20OXSR11.35475666
21PINK11.29235905
22GRK11.28820074
23TESK21.23981406
24ADRBK21.19627848
25ACVR1B1.10413489
26MAP4K21.10133540
27IRAK41.09420382
28PRKCG1.08359378
29PHKG11.00103335
30PHKG21.00103335
31TAOK10.99325875
32ERBB30.97301151
33MKNK20.90881856
34MAP3K40.87214118
35BUB10.84292602
36MINK10.79601594
37CSNK1G20.79335349
38CAMK2A0.78084830
39YES10.77738409
40ABL20.76618683
41PRKCE0.76379702
42TEC0.73971678
43INSRR0.72535748
44NUAK10.71243577
45MST40.71074119
46DYRK20.70605970
47UHMK10.70582155
48PRKD10.70411160
49MAPK120.68811922
50STK390.68661124
51PRKACB0.63967009
52LATS20.63902206
53MAP3K110.63630645
54PRKCI0.63574250
55PKN10.62859772
56SIK30.55013149
57CDK50.54916396
58TAOK30.54663487
59WNK40.54023241
60CHEK20.53312870
61PRKG10.52353798
62DDR20.50232262
63SGK10.49774093
64ADRBK10.49479714
65PRKD20.46732006
66KIT0.45320590
67IGF1R0.44959014
68STK110.42621482
69PTK2B0.41224103
70DYRK1A0.39710872
71CAMK2B0.38087892
72DAPK20.37341850
73GRK50.33976679
74PRKCH0.33226007
75PRKACA0.33023895
76PRKCZ0.32987523
77CSNK1G10.32772374
78INSR0.31581874
79STK38L0.30899827
80EIF2AK20.30704679
81RPS6KA30.30699236
82PRKD30.30483897
83PLK10.29414752
84PTK60.28305468
85IRAK20.27704494
86PRKCB0.26335709
87MET0.26218277
88PLK30.25439044
89STK40.25411702
90PRKCA0.25156600
91CSNK1D0.24690861
92CAMK2D0.23391244
93FER0.22093466
94CDK180.19336624
95CDK11A0.19268488
96CDK140.18922616
97CAMKK20.18628957
98CDK150.17601498
99STK240.17407918
100OBSCN0.17383354

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.98761326
2Taste transduction_Homo sapiens_hsa047422.77167630
3Basal transcription factors_Homo sapiens_hsa030222.75596812
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.70110988
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55062767
6GABAergic synapse_Homo sapiens_hsa047272.53305084
7Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.42752337
8Circadian entrainment_Homo sapiens_hsa047132.27741354
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.19351090
10Butanoate metabolism_Homo sapiens_hsa006502.10991025
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.10278982
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09435764
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08149043
14Glutamatergic synapse_Homo sapiens_hsa047242.05077507
15Morphine addiction_Homo sapiens_hsa050321.99352171
16Dopaminergic synapse_Homo sapiens_hsa047281.88865792
17Selenocompound metabolism_Homo sapiens_hsa004501.84318560
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.77744875
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.76542237
20Serotonergic synapse_Homo sapiens_hsa047261.64780964
21Amphetamine addiction_Homo sapiens_hsa050311.64566958
22Insulin secretion_Homo sapiens_hsa049111.63640687
23Cocaine addiction_Homo sapiens_hsa050301.61038208
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45872368
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42581795
26Cardiac muscle contraction_Homo sapiens_hsa042601.38389131
27Fatty acid elongation_Homo sapiens_hsa000621.35820987
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30859117
29Linoleic acid metabolism_Homo sapiens_hsa005911.28907460
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25022451
31Calcium signaling pathway_Homo sapiens_hsa040201.22418870
32Renin secretion_Homo sapiens_hsa049241.17724294
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16586826
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16521319
35Base excision repair_Homo sapiens_hsa034101.15271609
36Homologous recombination_Homo sapiens_hsa034401.12623860
37Chemical carcinogenesis_Homo sapiens_hsa052041.10748697
38ABC transporters_Homo sapiens_hsa020101.09858664
39Cholinergic synapse_Homo sapiens_hsa047251.09158762
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.08621468
41Phototransduction_Homo sapiens_hsa047441.03991072
42Type II diabetes mellitus_Homo sapiens_hsa049301.03350687
43Long-term potentiation_Homo sapiens_hsa047201.03233677
44Olfactory transduction_Homo sapiens_hsa047401.02996071
45Fatty acid metabolism_Homo sapiens_hsa012121.01156079
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.96860079
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90724655
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.89817677
49Synaptic vesicle cycle_Homo sapiens_hsa047210.89754062
50Peroxisome_Homo sapiens_hsa041460.85698189
51Asthma_Homo sapiens_hsa053100.84921962
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83696777
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82408062
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80471552
55RNA degradation_Homo sapiens_hsa030180.78569191
56Alzheimers disease_Homo sapiens_hsa050100.78129691
57cAMP signaling pathway_Homo sapiens_hsa040240.77592853
58Ether lipid metabolism_Homo sapiens_hsa005650.74410338
59Mineral absorption_Homo sapiens_hsa049780.73900920
60Propanoate metabolism_Homo sapiens_hsa006400.73821293
61Oxidative phosphorylation_Homo sapiens_hsa001900.73551790
62One carbon pool by folate_Homo sapiens_hsa006700.73496863
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72458626
64Non-homologous end-joining_Homo sapiens_hsa034500.70993920
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.69876465
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69640428
67Oxytocin signaling pathway_Homo sapiens_hsa049210.69347822
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69208560
69Salivary secretion_Homo sapiens_hsa049700.69163388
70Parkinsons disease_Homo sapiens_hsa050120.66882968
71Starch and sucrose metabolism_Homo sapiens_hsa005000.64911860
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64675843
73Gastric acid secretion_Homo sapiens_hsa049710.63889189
74Long-term depression_Homo sapiens_hsa047300.63494065
75Hippo signaling pathway_Homo sapiens_hsa043900.61993732
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60582800
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59107561
78Fatty acid biosynthesis_Homo sapiens_hsa000610.53986120
79Mismatch repair_Homo sapiens_hsa034300.53826845
80Protein export_Homo sapiens_hsa030600.53187242
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.52997217
82Tight junction_Homo sapiens_hsa045300.51960195
83Tryptophan metabolism_Homo sapiens_hsa003800.51776059
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.51333407
85Circadian rhythm_Homo sapiens_hsa047100.48256077
86Ras signaling pathway_Homo sapiens_hsa040140.47052660
87RNA polymerase_Homo sapiens_hsa030200.46233021
88Arachidonic acid metabolism_Homo sapiens_hsa005900.45134461
89Nitrogen metabolism_Homo sapiens_hsa009100.42019729
90Type I diabetes mellitus_Homo sapiens_hsa049400.40797394
91Collecting duct acid secretion_Homo sapiens_hsa049660.40243833
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37910197
93Retinol metabolism_Homo sapiens_hsa008300.34721260
94Steroid biosynthesis_Homo sapiens_hsa001000.34027037
95Oocyte meiosis_Homo sapiens_hsa041140.33241255
96Rheumatoid arthritis_Homo sapiens_hsa053230.33064458
97Fat digestion and absorption_Homo sapiens_hsa049750.32143866
98Huntingtons disease_Homo sapiens_hsa050160.30968232
99Hedgehog signaling pathway_Homo sapiens_hsa043400.29666111
100Metabolic pathways_Homo sapiens_hsa011000.28174993

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