ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mating behavior (GO:0007617)	7.23681961
2	sphingosine metabolic process (GO:0006670)	7.19674061
3	diol metabolic process (GO:0034311)	6.38245276
4	sphingoid metabolic process (GO:0046519)	6.33644967
5	seminiferous tubule development (GO:0072520)	5.85929402
6	DNA methylation involved in gamete generation (GO:0043046)	5.39415498
7	genitalia morphogenesis (GO:0035112)	5.37277934
8	lipopolysaccharide biosynthetic process (GO:0009103)	5.30005924
9	protein prenylation (GO:0018342)	5.28623647
10	prenylation (GO:0097354)	5.28623647
11	regulation of female gonad development (GO:2000194)	5.27344077
12	lipopolysaccharide metabolic process (GO:0008653)	4.76445938
13	positive regulation of male gonad development (GO:2000020)	4.63754560
14	piRNA metabolic process (GO:0034587)	4.44414886
15	protein-chromophore linkage (GO:0018298)	4.34730296
16	positive regulation of cGMP biosynthetic process (GO:0030828)	4.34252072
17	glomerular basement membrane development (GO:0032836)	4.11349336
18	regulation of cGMP biosynthetic process (GO:0030826)	4.05630925
19	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	4.05440361
20	regulation of pigment cell differentiation (GO:0050932)	3.96332705
21	positive regulation of developmental pigmentation (GO:0048087)	3.91801381
22	cellular response to gonadotropin stimulus (GO:0071371)	3.81702057
23	positive regulation of cGMP metabolic process (GO:0030825)	3.79175246
24	response to mercury ion (GO:0046689)	3.78513928
25	sulfate transmembrane transport (GO:1902358)	3.70626464
26	regulation of male gonad development (GO:2000018)	3.68690863
27	regulation of hippo signaling (GO:0035330)	3.63131367
28	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.59758551
29	protein import into peroxisome matrix (GO:0016558)	3.58840003
30	L-phenylalanine catabolic process (GO:0006559)	3.55351553
31	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.55351553
32	glycine transport (GO:0015816)	3.53357448
33	regulation of cGMP metabolic process (GO:0030823)	3.51995040
34	histone H3-K9 methylation (GO:0051567)	3.42457639
35	parturition (GO:0007567)	3.38741498
36	endocardial cushion development (GO:0003197)	3.34154619
37	short-chain fatty acid metabolic process (GO:0046459)	3.33165914
38	serotonin receptor signaling pathway (GO:0007210)	3.28997962
39	diaphragm development (GO:0060539)	3.28498849
40	skeletal muscle organ development (GO:0060538)	3.26394997
41	spermatid development (GO:0007286)	3.23371679
42	sex determination (GO:0007530)	3.22350577
43	regulation of meiosis I (GO:0060631)	3.20423152
44	behavioral response to nicotine (GO:0035095)	3.20340225
45	proline transport (GO:0015824)	3.19341823
46	regulation of gonadotropin secretion (GO:0032276)	3.15625860
47	negative regulation of metanephros development (GO:0072217)	3.14965555
48	rhodopsin mediated signaling pathway (GO:0016056)	3.14835451
49	cellular ketone body metabolic process (GO:0046950)	3.11004265
50	negative regulation of telomere maintenance (GO:0032205)	3.06756591
51	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	3.06729261
52	gonadal mesoderm development (GO:0007506)	3.04733924
53	dicarboxylic acid catabolic process (GO:0043649)	3.02504929
54	metanephric epithelium development (GO:0072207)	3.01990661
55	tyrosine metabolic process (GO:0006570)	3.01694182
56	positive regulation of metanephros development (GO:0072216)	3.00238544
57	aromatic amino acid family catabolic process (GO:0009074)	2.99943237
58	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.99842602
59	regulation of collateral sprouting (GO:0048670)	2.93553242
60	response to misfolded protein (GO:0051788)	2.93075005
61	epithelial cilium movement (GO:0003351)	2.92547483
62	sulfate transport (GO:0008272)	2.91501433
63	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.89751886
64	response to gonadotropin (GO:0034698)	2.87668089
65	regulation of metanephros development (GO:0072215)	2.86727487
66	cornea development in camera-type eye (GO:0061303)	2.84811694
67	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.82967512
68	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.82967512
69	peptidyl-proline hydroxylation (GO:0019511)	2.80602271
70	glycerol metabolic process (GO:0006071)	2.79631947
71	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.77010124
72	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.75688862
73	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	2.75671608
74	histone H3-K9 modification (GO:0061647)	2.74993192
75	indolalkylamine metabolic process (GO:0006586)	2.73986637
76	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.73736559
77	L-phenylalanine metabolic process (GO:0006558)	2.73736559
78	benzene-containing compound metabolic process (GO:0042537)	2.73295810
79	regulation of glomerulus development (GO:0090192)	2.72504252
80	regulation of cell proliferation involved in kidney development (GO:1901722)	2.72241456
81	ketone body metabolic process (GO:1902224)	2.71544411
82	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.70610226
83	sex differentiation (GO:0007548)	2.68662610
84	biotin metabolic process (GO:0006768)	2.68589855
85	aromatic amino acid family metabolic process (GO:0009072)	2.67684829
86	endoderm formation (GO:0001706)	2.67349171
87	SMAD protein signal transduction (GO:0060395)	2.62641779
88	gene silencing by RNA (GO:0031047)	2.62115689
89	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.61506078
90	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.61506078
91	regulation of posttranscriptional gene silencing (GO:0060147)	2.60709373
92	regulation of gene silencing by miRNA (GO:0060964)	2.60709373
93	regulation of gene silencing by RNA (GO:0060966)	2.60709373
94	lipid phosphorylation (GO:0046834)	2.58733525
95	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.55992630
96	gamma-aminobutyric acid transport (GO:0015812)	2.55622780
97	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.53864050
98	kynurenine metabolic process (GO:0070189)	2.53430239
99	sodium-independent organic anion transport (GO:0043252)	2.52625753
100	glomerulus development (GO:0032835)	2.50789234

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.77138204
2	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.98936626
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.41695616
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.33720852
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.21995681
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.66691134
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.64482413
8	AR_21572438_ChIP-Seq_LNCaP_Human	2.58622958
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.50366311
10	VDR_22108803_ChIP-Seq_LS180_Human	2.25588958
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.16774080
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.96128923
13	P300_19829295_ChIP-Seq_ESCs_Human	1.94097271
14	ER_23166858_ChIP-Seq_MCF-7_Human	1.90508496
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.86209805
16	DROSHA_22980978_ChIP-Seq_HELA_Human	1.85944977
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.65045225
18	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.61083312
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.57662199
20	TCF4_23295773_ChIP-Seq_U87_Human	1.56850285
21	HOXB7_26014856_ChIP-Seq_BT474_Human	1.52417446
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.50785201
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.49398316
24	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.47845677
25	REST_21632747_ChIP-Seq_MESCs_Mouse	1.47709460
26	STAT3_23295773_ChIP-Seq_U87_Human	1.42815536
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41818510
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.41818510
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.40668605
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.40109114
31	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.39804519
32	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.38584921
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.34328363
34	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.33433203
35	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32808366
36	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.32808366
37	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.30272553
38	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28233563
39	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.28136458
40	AR_25329375_ChIP-Seq_VCAP_Human	1.27432731
41	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.27426850
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.27127395
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.26910104
44	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.25935625
45	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.25880799
46	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.25429289
47	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.24803935
48	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.24269501
49	OCT4_20526341_ChIP-Seq_ESCs_Human	1.21615993
50	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.18057288
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18007980
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18007980
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17715777
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.16307483
55	NANOG_20526341_ChIP-Seq_ESCs_Human	1.16126663
56	BCAT_22108803_ChIP-Seq_LS180_Human	1.15248745
57	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.15240411
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14688641
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14377775
60	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.13522748
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13129135
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13129135
63	TP53_22573176_ChIP-Seq_HFKS_Human	1.13063620
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.12569863
65	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.12315347
66	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.11768211
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.08896260
68	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.08843991
69	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.07923874
70	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.07778032
71	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.07429245
72	STAT1_20625510_ChIP-Seq_HELA_Human	1.07249269
73	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.06627941
74	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.06575765
75	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.06209343
76	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.04614542
77	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.04373543
78	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.99926317
79	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.98625446
80	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98519324
81	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.98280187
82	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.97570648
83	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.97194346
84	NCOR_22424771_ChIP-Seq_293T_Human	0.96636438
85	TAF2_19829295_ChIP-Seq_ESCs_Human	0.96037827
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.96009780
87	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.95882091
88	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.94716973
89	AR_19668381_ChIP-Seq_PC3_Human	0.94191906
90	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94002008
91	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.93799035
92	MYC_19829295_ChIP-Seq_ESCs_Human	0.93677325
93	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.93128732
94	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.92883683
95	RUNX2_22187159_ChIP-Seq_PCA_Human	0.92802127
96	CDX2_22108803_ChIP-Seq_LS180_Human	0.92471378
97	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.91497046
98	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.90932389
99	STAT3_18555785_ChIP-Seq_MESCs_Mouse	0.90182519
100	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.89762967

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	6.48341614
2	MP0003136_yellow_coat_color	6.29126589
3	MP0002653_abnormal_ependyma_morphology	4.80527194
4	MP0008877_abnormal_DNA_methylation	4.34594424
5	MP0003890_abnormal_embryonic-extraembry	4.27118254
6	MP0005171_absent_coat_pigmentation	3.38253108
7	MP0003045_fibrosis	3.36172642
8	MP0003787_abnormal_imprinting	3.29204548
9	MP0003646_muscle_fatigue	3.00838203
10	MP0005646_abnormal_pituitary_gland	2.80739011
11	MP0005670_abnormal_white_adipose	2.69659555
12	MP0004381_abnormal_hair_follicle	2.29704210
13	MP0003879_abnormal_hair_cell	2.08227334
14	MP0002160_abnormal_reproductive_system	2.05547041
15	MP0005085_abnormal_gallbladder_physiolo	1.80965708
16	MP0004043_abnormal_pH_regulation	1.80850241
17	MP0001501_abnormal_sleep_pattern	1.73863203
18	MP0005389_reproductive_system_phenotype	1.73748658
19	MP0009046_muscle_twitch	1.73119677
20	MP0002332_abnormal_exercise_endurance	1.62279364
21	MP0003011_delayed_dark_adaptation	1.61860746
22	MP0001502_abnormal_circadian_rhythm	1.58661658
23	MP0009384_cardiac_valve_regurgitation	1.52699246
24	MP0004147_increased_porphyrin_level	1.49239854
25	MP0003195_calcinosis	1.45859661
26	MP0010386_abnormal_urinary_bladder	1.45467833
27	MP0001764_abnormal_homeostasis	1.43363961
28	MP0000013_abnormal_adipose_tissue	1.42931636
29	MP0004142_abnormal_muscle_tone	1.41834310
30	MP0008875_abnormal_xenobiotic_pharmacok	1.40631731
31	MP0008872_abnormal_physiological_respon	1.34934244
32	MP0002272_abnormal_nervous_system	1.26424409
33	MP0001984_abnormal_olfaction	1.26334725
34	MP0002909_abnormal_adrenal_gland	1.25948357
35	MP0000639_abnormal_adrenal_gland	1.25898948
36	MP0009745_abnormal_behavioral_response	1.25656345
37	MP0001968_abnormal_touch/_nociception	1.22659557
38	MP0002138_abnormal_hepatobiliary_system	1.21085629
39	MP0003121_genomic_imprinting	1.19242150
40	MP0005410_abnormal_fertilization	1.18900178
41	MP0000569_abnormal_digit_pigmentation	1.18264980
42	MP0005377_hearing/vestibular/ear_phenot	1.18256466
43	MP0003878_abnormal_ear_physiology	1.18256466
44	MP0005551_abnormal_eye_electrophysiolog	1.17666232
45	MP0002938_white_spotting	1.11465150
46	MP0006072_abnormal_retinal_apoptosis	1.07991246
47	MP0002735_abnormal_chemical_nociception	1.06674377
48	MP0001986_abnormal_taste_sensitivity	1.05901203
49	MP0001486_abnormal_startle_reflex	1.02378088
50	MP0001756_abnormal_urination	1.02284235
51	MP0001440_abnormal_grooming_behavior	1.01532308
52	MP0004145_abnormal_muscle_electrophysio	1.01160266
53	MP0003942_abnormal_urinary_system	0.98130146
54	MP0005253_abnormal_eye_physiology	0.92627108
55	MP0002210_abnormal_sex_determination	0.92406544
56	MP0002557_abnormal_social/conspecific_i	0.91526127
57	MP0005310_abnormal_salivary_gland	0.88437138
58	MP0003115_abnormal_respiratory_system	0.85176834
59	MP0008995_early_reproductive_senescence	0.83793717
60	MP0003698_abnormal_male_reproductive	0.83668324
61	MP0001188_hyperpigmentation	0.83118658
62	MP0005499_abnormal_olfactory_system	0.82931947
63	MP0005394_taste/olfaction_phenotype	0.82931947
64	MP0005075_abnormal_melanosome_morpholog	0.82316499
65	MP0003119_abnormal_digestive_system	0.81706482
66	MP0003567_abnormal_fetal_cardiomyocyte	0.80973594
67	MP0004130_abnormal_muscle_cell	0.79499603
68	MP0001529_abnormal_vocalization	0.79285032
69	MP0001919_abnormal_reproductive_system	0.78806268
70	MP0001348_abnormal_lacrimal_gland	0.78184072
71	MP0002168_other_aberrant_phenotype	0.78076984
72	MP0001145_abnormal_male_reproductive	0.78072999
73	MP0003635_abnormal_synaptic_transmissio	0.77333589
74	MP0000427_abnormal_hair_cycle	0.75745118
75	MP0002064_seizures	0.74339779
76	MP0001970_abnormal_pain_threshold	0.70579187
77	MP0002733_abnormal_thermal_nociception	0.69925872
78	MP0004484_altered_response_of	0.69703745
79	MP0000538_abnormal_urinary_bladder	0.69383948
80	MP0002572_abnormal_emotion/affect_behav	0.67617250
81	MP0002229_neurodegeneration	0.67117395
82	MP0002277_abnormal_respiratory_mucosa	0.67050169
83	MP0000653_abnormal_sex_gland	0.66717207
84	MP0000383_abnormal_hair_follicle	0.65077460
85	MP0003953_abnormal_hormone_level	0.64422130
86	MP0001270_distended_abdomen	0.64230684
87	MP0001944_abnormal_pancreas_morphology	0.63185044
88	MP0003137_abnormal_impulse_conducting	0.62757006
89	MP0005365_abnormal_bile_salt	0.60793182
90	MP0005379_endocrine/exocrine_gland_phen	0.60477891
91	MP0002693_abnormal_pancreas_physiology	0.60477037
92	MP0002063_abnormal_learning/memory/cond	0.59486614
93	MP0004885_abnormal_endolymph	0.58450329
94	MP0001664_abnormal_digestion	0.57515411
95	MP0003385_abnormal_body_wall	0.57431847
96	MP0002106_abnormal_muscle_physiology	0.56426161
97	MP0004085_abnormal_heartbeat	0.55862599
98	MP0002075_abnormal_coat/hair_pigmentati	0.55247811
99	MP0001765_abnormal_ion_homeostasis	0.52639932
100	MP0002132_abnormal_respiratory_system	0.52597515

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Amelogenesis imperfecta (HP:0000705)	5.26283309
2	Testicular neoplasm (HP:0010788)	4.71541313
3	Gonadal dysgenesis (HP:0000133)	4.62069208
4	Papilledema (HP:0001085)	4.34900339
5	Focal motor seizures (HP:0011153)	4.32805097
6	Pancreatic cysts (HP:0001737)	3.80275944
7	True hermaphroditism (HP:0010459)	3.74968021
8	Anomalous pulmonary venous return (HP:0010772)	3.74687564
9	Aplastic anemia (HP:0001915)	3.44122346
10	Mesangial abnormality (HP:0001966)	3.42706428
11	Parakeratosis (HP:0001036)	3.41769506
12	Abnormality of the pulmonary veins (HP:0011718)	3.28050475
13	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.18423811
14	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.18423811
15	Severe visual impairment (HP:0001141)	3.16807425
16	Abnormality of midbrain morphology (HP:0002418)	3.13849201
17	Molar tooth sign on MRI (HP:0002419)	3.13849201
18	Hypoplastic left heart (HP:0004383)	3.06565377
19	Nephronophthisis (HP:0000090)	2.95599588
20	Pendular nystagmus (HP:0012043)	2.89490955
21	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.79807765
22	Female pseudohermaphroditism (HP:0010458)	2.78343226
23	Broad alveolar ridges (HP:0000187)	2.76750044
24	Abnormality of the corticospinal tract (HP:0002492)	2.73111826
25	Paraplegia (HP:0010550)	2.72311685
26	Gaze-evoked nystagmus (HP:0000640)	2.68132474
27	Abnormality of the renal medulla (HP:0100957)	2.62002377
28	Male pseudohermaphroditism (HP:0000037)	2.61636946
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.61332539
30	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.57344144
31	Dialeptic seizures (HP:0011146)	2.56818149
32	Abnormality of the renal cortex (HP:0011035)	2.54393174
33	Urinary bladder sphincter dysfunction (HP:0002839)	2.53483111
34	Vertebral arch anomaly (HP:0008438)	2.49528802
35	Spastic paraplegia (HP:0001258)	2.47854903
36	Hypoplastic heart (HP:0001961)	2.44426870
37	Cystic liver disease (HP:0006706)	2.43744235
38	Bony spicule pigmentary retinopathy (HP:0007737)	2.43070086
39	Transposition of the great arteries (HP:0001669)	2.42306253
40	Abnormal connection of the cardiac segments (HP:0011545)	2.42306253
41	Abnormal ventriculo-arterial connection (HP:0011563)	2.42306253
42	Acanthocytosis (HP:0001927)	2.41457655
43	Hyperventilation (HP:0002883)	2.34587731
44	Chronic hepatic failure (HP:0100626)	2.33746678
45	Central scotoma (HP:0000603)	2.33367917
46	Neoplasm of the heart (HP:0100544)	2.30855175
47	Retinal dysplasia (HP:0007973)	2.28438663
48	Enlarged kidneys (HP:0000105)	2.23414250
49	Abnormality of the lower motor neuron (HP:0002366)	2.21870184
50	Syncope (HP:0001279)	2.20871781
51	Rectal prolapse (HP:0002035)	2.19412577
52	Opisthotonus (HP:0002179)	2.19163059
53	Abnormal albumin level (HP:0012116)	2.18754011
54	Hypoalbuminemia (HP:0003073)	2.18754011
55	Focal seizures (HP:0007359)	2.17876767
56	Scotoma (HP:0000575)	2.17279756
57	Abnormality of the vocal cords (HP:0008777)	2.16359681
58	Infertility (HP:0000789)	2.13350583
59	Abnormality of macular pigmentation (HP:0008002)	2.12034014
60	Bifid tongue (HP:0010297)	2.11617809
61	Overlapping toe (HP:0001845)	2.10415197
62	Palpebral edema (HP:0100540)	2.09803600
63	Attenuation of retinal blood vessels (HP:0007843)	2.07716158
64	Congenital stationary night blindness (HP:0007642)	2.03438933
65	Proximal amyotrophy (HP:0007126)	2.03265335
66	Polydipsia (HP:0001959)	2.03218234
67	Abnormal drinking behavior (HP:0030082)	2.03218234
68	Abnormality of the labia minora (HP:0012880)	2.02730769
69	Mitral stenosis (HP:0001718)	1.98294754
70	Dyschromatopsia (HP:0007641)	1.97445650
71	Congenital sensorineural hearing impairment (HP:0008527)	1.97337629
72	Urethral obstruction (HP:0000796)	1.97123477
73	Hypoplasia of the pons (HP:0012110)	1.95158768
74	Retinitis pigmentosa (HP:0000510)	1.93761191
75	Radial bowing (HP:0002986)	1.91799590
76	Embryonal renal neoplasm (HP:0011794)	1.90676234
77	Nephroblastoma (Wilms tumor) (HP:0002667)	1.90071812
78	Brushfield spots (HP:0001088)	1.89854967
79	Microretrognathia (HP:0000308)	1.88566267
80	Genetic anticipation (HP:0003743)	1.86646005
81	Male infertility (HP:0003251)	1.85897727
82	Turricephaly (HP:0000262)	1.85883810
83	Hyperglycinuria (HP:0003108)	1.83857946
84	Impaired smooth pursuit (HP:0007772)	1.83832098
85	Pancreatic fibrosis (HP:0100732)	1.82893334
86	Microvesicular hepatic steatosis (HP:0001414)	1.82505290
87	Ketosis (HP:0001946)	1.81805401
88	Absent speech (HP:0001344)	1.78251359
89	Impaired vibration sensation in the lower limbs (HP:0002166)	1.74873945
90	Abnormal sex determination (HP:0012244)	1.74559021
91	Sex reversal (HP:0012245)	1.74559021
92	Lissencephaly (HP:0001339)	1.74498030
93	Abnormal lung lobation (HP:0002101)	1.73241678
94	Neonatal hypoglycemia (HP:0001998)	1.72348187
95	Nonprogressive disorder (HP:0003680)	1.72316137
96	Recurrent gram-negative bacterial infections (HP:0005420)	1.71174919
97	Myokymia (HP:0002411)	1.70348536
98	Poor suck (HP:0002033)	1.69776924
99	Prolonged QT interval (HP:0001657)	1.69700200
100	Large eyes (HP:0001090)	1.69568097

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	7.26951308
2	STK38L	5.85126093
3	FRK	4.80681231
4	LATS2	3.49426634
5	MAP3K12	2.95826436
6	PRKD3	2.70801301
7	PINK1	2.53423034
8	WNK3	2.40808975
9	STK38	2.34868064
10	NLK	2.32367675
11	MAP2K2	2.17135014
12	TNK2	1.97969044
13	BMPR1B	1.95172995
14	ZAK	1.89060639
15	PIK3CG	1.73016115
16	NME1	1.70596329
17	CDK19	1.42585161
18	LMTK2	1.40345998
19	ADRBK2	1.37866122
20	TAOK3	1.33059323
21	MELK	1.27145219
22	INSRR	1.26898117
23	MAP3K11	1.17441915
24	DAPK2	1.14583754
25	STK3	1.11604284
26	NTRK3	1.09396382
27	MAP3K5	1.01622516
28	WNK4	0.98762097
29	PHKG2	0.97784427
30	PHKG1	0.97784427
31	MUSK	0.96822410
32	GRK1	0.96744014
33	PRKCE	0.94303606
34	ACVR1B	0.93513104
35	IRAK1	0.90650913
36	SIK3	0.88424065
37	PIK3CA	0.87580451
38	CSNK1A1L	0.83989154
39	GRK7	0.83881429
40	BRD4	0.83472810
41	PRKAA2	0.79834610
42	SIK2	0.75372390
43	YES1	0.74147035
44	PDPK1	0.70973627
45	PBK	0.70251880
46	ADRBK1	0.69531280
47	MAP2K4	0.69347666
48	TLK1	0.68986109
49	FER	0.67775256
50	STK39	0.66402135
51	EPHA3	0.64915696
52	GRK5	0.63479947
53	RPS6KA2	0.59033969
54	EPHB1	0.58680389
55	PRKD1	0.57786720
56	BCKDK	0.57185929
57	PLK2	0.55100190
58	CAMK1	0.53686286
59	PRKCG	0.53508279
60	TGFBR1	0.51798576
61	RET	0.51479767
62	MAP3K4	0.51235662
63	MAPK13	0.51181385
64	DYRK2	0.47895003
65	SGK223	0.46706316
66	SGK494	0.46706316
67	DYRK1A	0.46117187
68	CDK4	0.45807911
69	SGK2	0.44596302
70	MAP3K7	0.42425227
71	PRKG2	0.42352824
72	CDK3	0.42222843
73	NUAK1	0.39798680
74	NTRK2	0.39516131
75	MAPKAPK3	0.36506994
76	CSNK1D	0.36301460
77	OXSR1	0.36299693
78	STK11	0.36047383
79	MARK2	0.35925325
80	SGK1	0.34624897
81	PRKACA	0.33835715
82	MARK3	0.33003319
83	PRKCZ	0.32704301
84	CDK5	0.32268027
85	PIM1	0.31868002
86	CAMKK2	0.31810990
87	PDK1	0.30776766
88	CSNK1G2	0.30423642
89	MARK1	0.30046972
90	MAPK3	0.29087472
91	PRKAA1	0.28343293
92	CAMK2A	0.26780580
93	RPS6KA5	0.26024705
94	RPS6KA6	0.24295527
95	MAPKAPK5	0.23951572
96	PRKG1	0.22700060
97	ITK	0.20392823
98	RPS6KA3	0.19935468
99	RPS6KB1	0.19121109
100	MAP3K2	0.18962538

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.69653300
2	Butanoate metabolism_Homo sapiens_hsa00650	4.08547449
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.64988149
4	Phototransduction_Homo sapiens_hsa04744	3.48354829
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.73470143
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.60379792
7	GABAergic synapse_Homo sapiens_hsa04727	2.35930700
8	Morphine addiction_Homo sapiens_hsa05032	2.35843094
9	Nicotine addiction_Homo sapiens_hsa05033	2.28489974
10	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.16335301
11	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.06984895
12	Taste transduction_Homo sapiens_hsa04742	2.04493512
13	Sphingolipid metabolism_Homo sapiens_hsa00600	2.03670789
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.02529491
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.88904670
16	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.82320731
17	Circadian entrainment_Homo sapiens_hsa04713	1.81691456
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.77425461
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.75705201
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.64161185
21	Olfactory transduction_Homo sapiens_hsa04740	1.59529415
22	One carbon pool by folate_Homo sapiens_hsa00670	1.53740040
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.48376406
24	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.48015276
25	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.47814829
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.23778761
27	RNA polymerase_Homo sapiens_hsa03020	1.23396145
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.20903069
29	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.14771431
30	Phenylalanine metabolism_Homo sapiens_hsa00360	1.09139926
31	Insulin secretion_Homo sapiens_hsa04911	1.07040302
32	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.05384205
33	Glutamatergic synapse_Homo sapiens_hsa04724	1.05314289
34	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.03843326
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.02942598
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.02823666
37	Serotonergic synapse_Homo sapiens_hsa04726	1.02621685
38	ABC transporters_Homo sapiens_hsa02010	0.98905019
39	Propanoate metabolism_Homo sapiens_hsa00640	0.98504859
40	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.94354988
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.93761857
42	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.92069435
43	Linoleic acid metabolism_Homo sapiens_hsa00591	0.89551889
44	Bile secretion_Homo sapiens_hsa04976	0.89481939
45	Retinol metabolism_Homo sapiens_hsa00830	0.87426660
46	Calcium signaling pathway_Homo sapiens_hsa04020	0.83444144
47	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.81259987
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.79545026
49	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.79197887
50	Peroxisome_Homo sapiens_hsa04146	0.78280304
51	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.78066154
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.77142264
53	Salivary secretion_Homo sapiens_hsa04970	0.75796269
54	Collecting duct acid secretion_Homo sapiens_hsa04966	0.75096476
55	Fatty acid degradation_Homo sapiens_hsa00071	0.73784938
56	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.71428370
57	Lysine degradation_Homo sapiens_hsa00310	0.70720883
58	Complement and coagulation cascades_Homo sapiens_hsa04610	0.69757565
59	Folate biosynthesis_Homo sapiens_hsa00790	0.69191167
60	Gastric acid secretion_Homo sapiens_hsa04971	0.67312761
61	Cholinergic synapse_Homo sapiens_hsa04725	0.63261455
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.63003888
63	Circadian rhythm_Homo sapiens_hsa04710	0.62696507
64	Vibrio cholerae infection_Homo sapiens_hsa05110	0.61703279
65	Histidine metabolism_Homo sapiens_hsa00340	0.60350760
66	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.59217244
67	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.58736104
68	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.58354839
69	Purine metabolism_Homo sapiens_hsa00230	0.56343722
70	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55945509
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55422183
72	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.53474557
73	Metabolic pathways_Homo sapiens_hsa01100	0.51900977
74	Tyrosine metabolism_Homo sapiens_hsa00350	0.51795972
75	Pancreatic secretion_Homo sapiens_hsa04972	0.50068761
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.49326779
77	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.47573457
78	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.45589108
79	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.43087726
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40993561
81	Homologous recombination_Homo sapiens_hsa03440	0.39950905
82	Basal cell carcinoma_Homo sapiens_hsa05217	0.37374035
83	cAMP signaling pathway_Homo sapiens_hsa04024	0.34642111
84	Sulfur relay system_Homo sapiens_hsa04122	0.33559725
85	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.33409938
86	Sulfur metabolism_Homo sapiens_hsa00920	0.33237698
87	Glutathione metabolism_Homo sapiens_hsa00480	0.33041465
88	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.32325317
89	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.31206613
90	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.30584550
91	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.29930757
92	Oxidative phosphorylation_Homo sapiens_hsa00190	0.29481097
93	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.28795606
94	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.28345762
95	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.27980437
96	AMPK signaling pathway_Homo sapiens_hsa04152	0.27881137
97	Steroid biosynthesis_Homo sapiens_hsa00100	0.27755706
98	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.26603188
99	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.24558374
100	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.24060058

MTND5P19

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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