MTND5P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of glucose import in response to insulin stimulus (GO:2001273)9.44599695
2negative regulation of glucose transport (GO:0010829)8.90760918
3regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022358.69401121
4interleukin-6-mediated signaling pathway (GO:0070102)6.91129315
5ER overload response (GO:0006983)6.42634420
6signal peptide processing (GO:0006465)6.19652068
7cellular response to ethanol (GO:0071361)5.80917643
8GDP-mannose metabolic process (GO:0019673)5.32437716
9protein maturation by protein folding (GO:0022417)4.86516923
10histone-serine phosphorylation (GO:0035404)4.78449366
11histone H3-K4 trimethylation (GO:0080182)4.72252678
12negative regulation of cellular response to insulin stimulus (GO:1900077)4.58405346
13regulation of energy homeostasis (GO:2000505)4.56775865
14regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.37984258
15positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.37984258
16regulation of type B pancreatic cell apoptotic process (GO:2000674)4.36745791
17lipopolysaccharide biosynthetic process (GO:0009103)4.20401369
18cellular response to glucose starvation (GO:0042149)4.18709291
19ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.12467322
20rRNA catabolic process (GO:0016075)3.97805249
21mannose metabolic process (GO:0006013)3.97150813
22negative regulation of glycogen biosynthetic process (GO:0045719)3.95071263
23lipopolysaccharide metabolic process (GO:0008653)3.94749233
24hepatocyte apoptotic process (GO:0097284)3.92443150
25proline transport (GO:0015824)3.83711855
26cellular response to exogenous dsRNA (GO:0071360)3.82875035
27nucleotide-sugar biosynthetic process (GO:0009226)3.82718808
28regulation of fibroblast apoptotic process (GO:2000269)3.79681412
29definitive hemopoiesis (GO:0060216)3.74520998
30peptidyl-lysine trimethylation (GO:0018023)3.74388633
31positive regulation of protein homooligomerization (GO:0032464)3.71275914
32embryonic process involved in female pregnancy (GO:0060136)3.70125103
33natural killer cell activation involved in immune response (GO:0002323)3.68066012
34regulation of MHC class I biosynthetic process (GO:0045343)3.66132702
35regulation of B cell proliferation (GO:0030888)3.63225096
36positive regulation of phosphatase activity (GO:0010922)3.63057871
37indolalkylamine metabolic process (GO:0006586)3.58857502
38regulation of DNA endoreduplication (GO:0032875)3.57681249
39labyrinthine layer development (GO:0060711)3.53610420
40NIK/NF-kappaB signaling (GO:0038061)3.48054543
41positive regulation of histone H3-K4 methylation (GO:0051571)3.47842697
42positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.42039829
43positive regulation of mitotic sister chromatid separation (GO:1901970)3.42039829
44positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.42039829
45cobalamin metabolic process (GO:0009235)3.41267639
46response to hydroperoxide (GO:0033194)3.30740490
47positive regulation of toll-like receptor signaling pathway (GO:0034123)3.22227910
48dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.20796425
49positive regulation of glycolytic process (GO:0045821)3.13925873
50cytokine biosynthetic process (GO:0042089)3.13236732
51folic acid metabolic process (GO:0046655)3.11902431
52regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.10323498
53positive regulation of steroid biosynthetic process (GO:0010893)3.08810388
54rRNA methylation (GO:0031167)3.07201069
55nucleotide-sugar metabolic process (GO:0009225)3.07095826
56fatty acid homeostasis (GO:0055089)3.06491993
57pseudouridine synthesis (GO:0001522)3.05105488
58cellular response to interleukin-6 (GO:0071354)3.02053693
59I-kappaB kinase/NF-kappaB signaling (GO:0007249)3.02004138
60methionine biosynthetic process (GO:0009086)2.96714256
61negative regulation of glycogen metabolic process (GO:0070874)2.96463705
62nucleoside diphosphate catabolic process (GO:0009134)2.95448812
63snRNA transcription (GO:0009301)2.88853658
64glycosylceramide metabolic process (GO:0006677)2.88438829
65UDP-N-acetylglucosamine metabolic process (GO:0006047)2.87673533
66tyrosine phosphorylation of STAT protein (GO:0007260)2.87361663
67transcytosis (GO:0045056)2.87229832
68N-terminal protein amino acid acetylation (GO:0006474)2.86360037
69natural killer cell differentiation (GO:0001779)2.86226250
70detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.85491774
71negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.85454363
72positive regulation of steroid hormone secretion (GO:2000833)2.83777235
73regulation of triglyceride catabolic process (GO:0010896)2.80221603
74transcription from mitochondrial promoter (GO:0006390)2.78545249
75histone deubiquitination (GO:0016578)2.78470867
76monoubiquitinated protein deubiquitination (GO:0035520)2.77026077
77developmental pigmentation (GO:0048066)2.73584049
78positive regulation of alcohol biosynthetic process (GO:1902932)2.72975730
79intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.71958252
80negative regulation of lipid catabolic process (GO:0050995)2.71827976
81glycolipid catabolic process (GO:0019377)2.71254734
82regulation of Rac protein signal transduction (GO:0035020)2.70076166
83activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.66636582
84peptidyl-lysine methylation (GO:0018022)2.65970252
85negative regulation by host of viral transcription (GO:0043922)2.65496376
86endoplasmic reticulum unfolded protein response (GO:0030968)2.64178810
87cellular response to unfolded protein (GO:0034620)2.64132631
88response to caffeine (GO:0031000)2.63263365
89positive regulation of autophagy (GO:0010508)2.63056050
90regulation of cellular extravasation (GO:0002691)2.62997112
91negative regulation of neurotransmitter secretion (GO:0046929)2.61800483
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.61606791
93RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.61606791
94cytokine metabolic process (GO:0042107)2.60309440
95positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.59941523
96inositol metabolic process (GO:0006020)2.58828965
97regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.58112098
98RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.57196696
99cellular response to dsRNA (GO:0071359)2.56968937
100negative regulation of glucose import (GO:0046325)10.1013500

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.53939627
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.48290257
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.22448270
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.98482886
5IRF1_19129219_ChIP-ChIP_H3396_Human2.59149056
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46022033
7VDR_22108803_ChIP-Seq_LS180_Human2.25993718
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.23624801
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06298792
10PADI4_21655091_ChIP-ChIP_MCF-7_Human2.03602780
11ER_23166858_ChIP-Seq_MCF-7_Human2.02565327
12TAF15_26573619_Chip-Seq_HEK293_Human1.91517954
13GATA3_26560356_Chip-Seq_TH2_Human1.87862717
14IRF8_21731497_ChIP-ChIP_J774_Mouse1.83458047
15SMAD_19615063_ChIP-ChIP_OVARY_Human1.81644662
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78171867
17PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67913069
18ZNF274_21170338_ChIP-Seq_K562_Hela1.64469545
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63471885
20IGF1R_20145208_ChIP-Seq_DFB_Human1.58456052
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57948305
22MYB_26560356_Chip-Seq_TH2_Human1.55711712
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55188319
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53081226
25GATA3_27048872_Chip-Seq_THYMUS_Human1.51386167
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51167676
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50892599
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.50449889
29AR_21572438_ChIP-Seq_LNCaP_Human1.45419544
30VDR_23849224_ChIP-Seq_CD4+_Human1.45196228
31PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.44848564
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44276836
33EWS_26573619_Chip-Seq_HEK293_Human1.43945702
34SCL_19346495_ChIP-Seq_HPC-7_Human1.43366408
35GATA1_22025678_ChIP-Seq_K562_Human1.43088486
36P300_19829295_ChIP-Seq_ESCs_Human1.42541666
37CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.41153215
38ELK1_19687146_ChIP-ChIP_HELA_Human1.39860962
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.39803618
40TFEB_21752829_ChIP-Seq_HELA_Human1.39187911
41KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38687015
42RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37585589
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35978561
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.35475118
45CBP_20019798_ChIP-Seq_JUKART_Human1.35075971
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35075971
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31669918
48HTT_18923047_ChIP-ChIP_STHdh_Human1.31387760
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.28858875
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28230748
51BCAT_22108803_ChIP-Seq_LS180_Human1.28115455
52PRDM14_20953172_ChIP-Seq_ESCs_Human1.28058263
53SALL4_22934838_ChIP-ChIP_CD34+_Human1.26212158
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26020556
55RUNX_20019798_ChIP-Seq_JUKART_Human1.25787324
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24295085
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23547126
58TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.22038006
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21027500
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20465213
61TCF4_22108803_ChIP-Seq_LS180_Human1.20264393
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19856259
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17412845
64ETV1_20927104_ChIP-Seq_GIST48_Human1.14720523
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14432467
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14369392
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14369392
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14144949
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.13662830
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.12102863
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11681434
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.11363993
73CDX2_22108803_ChIP-Seq_LS180_Human1.10658285
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10558127
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09790349
76AR_25329375_ChIP-Seq_VCAP_Human1.08725719
77IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07406281
78CBX2_22325352_ChIP-Seq_293T-Rex_Human1.06114918
79TCF4_23295773_ChIP-Seq_U87_Human1.05737493
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05579161
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05544241
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05044397
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03497709
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03386496
85RBPJ_21746931_ChIP-Seq_IB4_Human1.03268430
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.03174794
87TP53_22573176_ChIP-Seq_HFKS_Human1.02944222
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.02767560
89GATA3_26560356_Chip-Seq_TH1_Human0.99768542
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99475099
91SMRT_27268052_Chip-Seq_Bcells_Human0.97788827
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97636398
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97553117
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97310293
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96326681
96PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.95914121
97E2F1_18555785_Chip-Seq_ESCs_Mouse0.95569788
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94650981
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92840766
100NMYC_18555785_Chip-Seq_ESCs_Mouse0.92164329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000015_abnormal_ear_pigmentation5.26037207
2MP0000569_abnormal_digit_pigmentation3.70171958
3MP0003950_abnormal_plasma_membrane3.19405510
4MP0010386_abnormal_urinary_bladder2.98509854
5MP0003656_abnormal_erythrocyte_physiolo2.97696561
6MP0003195_calcinosis2.95399318
7MP0002254_reproductive_system_inflammat2.77558389
8MP0004036_abnormal_muscle_relaxation2.67583068
9MP0002653_abnormal_ependyma_morphology2.61002251
10MP0005671_abnormal_response_to2.55272647
11MP0001529_abnormal_vocalization2.54441914
12MP0004084_abnormal_cardiac_muscle2.37398006
13MP0003718_maternal_effect2.35319443
14MP0002148_abnormal_hypersensitivity_rea2.29725845
15MP0004145_abnormal_muscle_electrophysio2.19323556
16MP0008877_abnormal_DNA_methylation2.18507780
17MP0003045_fibrosis2.15580122
18MP0001800_abnormal_humoral_immune2.09445223
19MP0002095_abnormal_skin_pigmentation2.02689985
20MP0001666_abnormal_nutrient_absorption1.78434424
21MP0005174_abnormal_tail_pigmentation1.77175452
22MP0005332_abnormal_amino_acid1.76048437
23MP0001835_abnormal_antigen_presentation1.74777856
24MP0004808_abnormal_hematopoietic_stem1.69155856
25MP0005464_abnormal_platelet_physiology1.67981868
26MP0004130_abnormal_muscle_cell1.65592994
27MP0003868_abnormal_feces_composition1.62985520
28MP0002277_abnormal_respiratory_mucosa1.62245929
29MP0005395_other_phenotype1.56567821
30MP0002452_abnormal_antigen_presenting1.55714857
31MP0001501_abnormal_sleep_pattern1.51125746
32MP0008872_abnormal_physiological_respon1.49585440
33MP0005000_abnormal_immune_tolerance1.46983852
34MP0005397_hematopoietic_system_phenotyp1.37028052
35MP0001545_abnormal_hematopoietic_system1.37028052
36MP0002723_abnormal_immune_serum1.36443024
37MP0002168_other_aberrant_phenotype1.29533171
38MP0002102_abnormal_ear_morphology1.23287769
39MP0008007_abnormal_cellular_replicative1.22969130
40MP0002693_abnormal_pancreas_physiology1.22498025
41MP0001873_stomach_inflammation1.21892038
42MP0005551_abnormal_eye_electrophysiolog1.20895745
43MP0005171_absent_coat_pigmentation1.20378022
44MP0002420_abnormal_adaptive_immunity1.20347540
45MP0004142_abnormal_muscle_tone1.18932026
46MP0001819_abnormal_immune_cell1.18708137
47MP0002398_abnormal_bone_marrow1.15357380
48MP0000689_abnormal_spleen_morphology1.14369007
49MP0009764_decreased_sensitivity_to1.12596102
50MP0005167_abnormal_blood-brain_barrier1.12122569
51MP0000371_diluted_coat_color1.09213658
52MP0005386_behavior/neurological_phenoty1.08149929
53MP0004924_abnormal_behavior1.08149929
54MP0001919_abnormal_reproductive_system1.07119708
55MP0002138_abnormal_hepatobiliary_system1.06382129
56MP0002396_abnormal_hematopoietic_system1.06103231
57MP0008875_abnormal_xenobiotic_pharmacok1.03388050
58MP0005365_abnormal_bile_salt1.00391957
59MP0002132_abnormal_respiratory_system0.99635531
60MP0001191_abnormal_skin_condition0.98591249
61MP0000716_abnormal_immune_system0.96994836
62MP0000685_abnormal_immune_system0.94919433
63MP0002136_abnormal_kidney_physiology0.93427381
64MP0004742_abnormal_vestibular_system0.92979281
65MP0002876_abnormal_thyroid_physiology0.92920676
66MP0002419_abnormal_innate_immunity0.92870612
67MP0003252_abnormal_bile_duct0.92381932
68MP0001845_abnormal_inflammatory_respons0.90673353
69MP0004270_analgesia0.90043042
70MP0005085_abnormal_gallbladder_physiolo0.89831667
71MP0002933_joint_inflammation0.89688128
72MP0000372_irregular_coat_pigmentation0.88941131
73MP0002295_abnormal_pulmonary_circulatio0.87022708
74MP0001986_abnormal_taste_sensitivity0.86061633
75MP0005075_abnormal_melanosome_morpholog0.86010616
76MP0001727_abnormal_embryo_implantation0.85684599
77MP0001764_abnormal_homeostasis0.84305465
78MP0000427_abnormal_hair_cycle0.84086292
79MP0002127_abnormal_cardiovascular_syste0.84034164
80MP0002722_abnormal_immune_system0.83744679
81MP0004885_abnormal_endolymph0.80641334
82MP0000639_abnormal_adrenal_gland0.79286812
83MP0002429_abnormal_blood_cell0.78748930
84MP0005448_abnormal_energy_balance0.76109289
85MP0009697_abnormal_copulation0.75862088
86MP0001765_abnormal_ion_homeostasis0.72960964
87MP0003646_muscle_fatigue0.70732011
88MP0005645_abnormal_hypothalamus_physiol0.70445739
89MP0004043_abnormal_pH_regulation0.69014864
90MP0003763_abnormal_thymus_physiology0.66529478
91MP0003943_abnormal_hepatobiliary_system0.66243460
92MP0004134_abnormal_chest_morphology0.64397136
93MP0001348_abnormal_lacrimal_gland0.63434661
94MP0009745_abnormal_behavioral_response0.62338486
95MP0004484_altered_response_of0.61991475
96MP0005584_abnormal_enzyme/coenzyme_acti0.61286940
97MP0005389_reproductive_system_phenotype0.60175348
98MP0003303_peritoneal_inflammation0.59156205
99MP0000538_abnormal_urinary_bladder0.58908737
100MP0000470_abnormal_stomach_morphology0.58215302

Predicted human phenotypes

RankGene SetZ-score
1Nonimmune hydrops fetalis (HP:0001790)7.46538479
2Type I transferrin isoform profile (HP:0003642)5.88893260
3Reduced antithrombin III activity (HP:0001976)5.55662774
4Hypoplasia of the pons (HP:0012110)5.31511303
5Abnormality of the pons (HP:0007361)5.01126232
6Spastic paraparesis (HP:0002313)4.43500501
7Abnormal protein glycosylation (HP:0012346)4.27969289
8Abnormal glycosylation (HP:0012345)4.27969289
9Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.27969289
10Abnormal protein N-linked glycosylation (HP:0012347)4.27969289
11Thrombocytosis (HP:0001894)4.23726018
12Megaloblastic anemia (HP:0001889)4.16170918
13Testicular atrophy (HP:0000029)4.08579687
14Global brain atrophy (HP:0002283)3.96934457
15Abnormality of the intrinsic pathway (HP:0010989)3.71089404
16Cutaneous melanoma (HP:0012056)3.68300333
17Glucose intolerance (HP:0000833)3.65970875
18Acute hepatic failure (HP:0006554)3.64999260
19Prolonged partial thromboplastin time (HP:0003645)3.58279227
20Abnormality of homocysteine metabolism (HP:0010919)3.42533505
21Homocystinuria (HP:0002156)3.42533505
22Nuclear cataract (HP:0100018)3.34570047
23Chronic sinusitis (HP:0011109)3.18571988
24Hypokinesia (HP:0002375)3.09786021
25Follicular hyperkeratosis (HP:0007502)3.07582233
26Albinism (HP:0001022)3.05970406
27Abnormal albumin level (HP:0012116)3.02607905
28Hypoalbuminemia (HP:0003073)3.02607905
29Vacuolated lymphocytes (HP:0001922)2.91214155
30Agammaglobulinemia (HP:0004432)2.90602500
31Curly hair (HP:0002212)2.83240147
32Gingival bleeding (HP:0000225)2.82565284
33IgA deficiency (HP:0002720)2.82517774
34Paraparesis (HP:0002385)2.81269658
35Hyperglycinuria (HP:0003108)2.80310507
36Hydroxyprolinuria (HP:0003080)2.75864038
37Abnormality of proline metabolism (HP:0010907)2.75864038
38Stomatitis (HP:0010280)2.63966248
39Poor eye contact (HP:0000817)2.59764667
40Abnormal glucose tolerance (HP:0001952)2.57503381
41Spontaneous abortion (HP:0005268)2.54202332
42Pancreatic cysts (HP:0001737)2.51624656
43Proximal tubulopathy (HP:0000114)2.44402002
44Keratoconus (HP:0000563)2.43831211
45Increased corneal curvature (HP:0100692)2.43831211
46Abnormality of methionine metabolism (HP:0010901)2.38253225
47Hypothermia (HP:0002045)2.37324817
48IgG deficiency (HP:0004315)2.37181601
49Gastrointestinal infarctions (HP:0005244)2.33732425
50Entropion (HP:0000621)2.31034845
51Verrucae (HP:0200043)2.30686738
52Papilloma (HP:0012740)2.30686738
53Abnormality of the vitamin B12 metabolism (HP:0004341)2.29389795
54Recurrent pneumonia (HP:0006532)2.28696383
55Abnormal rod and cone electroretinograms (HP:0008323)2.27259100
56Progressive sensorineural hearing impairment (HP:0000408)2.22330153
57Exocrine pancreatic insufficiency (HP:0001738)2.19074225
58Keratitis (HP:0000491)2.17408275
59Severe visual impairment (HP:0001141)2.17259666
60Chronic hepatic failure (HP:0100626)2.14873669
61Vertebral compression fractures (HP:0002953)2.13710482
62Abnormality of vitamin B metabolism (HP:0004340)2.12591699
63Neutropenia (HP:0001875)2.08355196
64Abnormality of the prostate (HP:0008775)2.05694415
65Abnormal social behavior (HP:0012433)2.03459819
66Impaired social interactions (HP:0000735)2.03459819
67Portal hypertension (HP:0001409)2.01345283
68Congenital stationary night blindness (HP:0007642)1.99666405
69Cerebral hemorrhage (HP:0001342)1.99326189
70Peritonitis (HP:0002586)1.98711004
71Poikiloderma (HP:0001029)1.96608990
72Abnormality of the pericardium (HP:0001697)1.96292766
73Deep philtrum (HP:0002002)1.94877450
74Vascular calcification (HP:0004934)1.92608957
75Microvesicular hepatic steatosis (HP:0001414)1.91783003
76Pancreatic fibrosis (HP:0100732)1.91767981
77Metaphyseal dysplasia (HP:0100255)1.91628904
78Stroke (HP:0001297)1.90914802
79Myocardial infarction (HP:0001658)1.89465382
80Chest pain (HP:0100749)1.88387954
81Abnormality of the hepatic vasculature (HP:0006707)1.87969011
82Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85346248
83Abnormality of glycine metabolism (HP:0010895)1.83315725
84Abnormality of serine family amino acid metabolism (HP:0010894)1.83315725
85Generalized hypopigmentation of hair (HP:0011358)1.82847368
86Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.82078323
87True hermaphroditism (HP:0010459)1.78683667
88Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77682376
89Pulmonary infiltrates (HP:0002113)1.77552278
90Epistaxis (HP:0000421)1.76333648
91Asymmetry of the thorax (HP:0001555)1.76013974
92Esotropia (HP:0000565)1.75018171
93Diminished movement (HP:0002374)1.73746142
94Exertional dyspnea (HP:0002875)1.71224514
95Hypoproteinemia (HP:0003075)1.70884630
96Decreased circulating renin level (HP:0003351)1.70398033
97Abnormality of subcutaneous fat tissue (HP:0001001)1.69326867
98Abnormality of liposaccharide metabolism (HP:0010968)1.68900514
99Abnormality of glycosphingolipid metabolism (HP:0004343)1.68900514
100Abnormality of glycolipid metabolism (HP:0010969)1.68900514

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMKK27.09858939
2BRSK26.60149706
3PKN25.27814340
4FLT34.24110789
5AKT33.54565806
6CAMKK13.34718354
7BRSK12.64728145
8IRAK22.58887043
9IRAK12.35555977
10IRAK42.32762841
11EIF2AK32.31166680
12PIK3CG2.28785077
13TEC1.99526624
14BMPR1B1.88817520
15FRK1.60181045
16TLK11.34593230
17MET1.32756594
18MAPKAPK51.29754811
19ITK1.26932598
20ACVR1B1.26651851
21PASK1.20733280
22LATS11.18742348
23BTK1.15799869
24NUAK11.12966227
25TAOK31.09062185
26TYK21.04259119
27WNK41.02702286
28MAP3K91.02459592
29PAK31.00522718
30MKNK20.99647831
31TXK0.99401520
32MST40.95003310
33SIK30.92217754
34STK38L0.88275023
35IKBKE0.87908268
36SYK0.86027064
37PDK20.85355268
38JAK30.83064206
39HCK0.80565568
40MAP3K140.78737673
41PRKAA20.76990578
42STK240.76961930
43MAPKAPK30.76150098
44CAMK1D0.74777592
45MAPK110.71803584
46MKNK10.68946666
47INSRR0.68514600
48PKN10.67657202
49TBK10.63478427
50CAMK10.63440792
51STK30.61574485
52IGF1R0.61080658
53TIE10.59193522
54MAP3K120.58237043
55ERBB30.57431246
56STK110.57128123
57GRK10.55218087
58IKBKB0.54057296
59STK40.41685574
60BLK0.41470575
61TRPM70.37964153
62JAK20.37805927
63CHUK0.37237104
64OXSR10.37098302
65BUB10.37088641
66PRKCQ0.36659377
67CAMK1G0.35394035
68MAPK130.34350523
69FGFR10.34312985
70BRD40.31241107
71MAP3K50.31240157
72PRKAA10.31066364
73ABL10.30778385
74EIF2AK20.30511294
75BCKDK0.28727316
76PNCK0.27837493
77KIT0.26796403
78MELK0.23488901
79CHEK10.21126799
80RPS6KB20.19197690
81ADRBK20.19155998
82WNK10.15885921
83CAMK40.15394062
84ADRBK10.15385544
85MAPK30.14137375
86SGK20.13533506
87BMPR20.13255670
88MAP3K60.13125506
89GRK70.12541890
90CAMK2B0.12394932
91VRK20.11404542
92PDK10.11279945
93TRIM280.11255847
94STK390.11250513
95LYN0.10503526
96TGFBR10.10416250
97RET0.10071979
98GRK50.08561198
99MAPK10.08451474
100VRK10.08441827

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.85884819
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.90186859
3Asthma_Homo sapiens_hsa053103.27112986
4Basal transcription factors_Homo sapiens_hsa030222.80404819
5Regulation of autophagy_Homo sapiens_hsa041402.75390868
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.46662154
7Primary immunodeficiency_Homo sapiens_hsa053402.33916801
8Pancreatic secretion_Homo sapiens_hsa049722.30072506
9Allograft rejection_Homo sapiens_hsa053302.07807204
10Graft-versus-host disease_Homo sapiens_hsa053322.06895138
11Autoimmune thyroid disease_Homo sapiens_hsa053201.96356066
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95239767
13Circadian rhythm_Homo sapiens_hsa047101.88235628
14RNA degradation_Homo sapiens_hsa030181.76391188
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74298141
16Olfactory transduction_Homo sapiens_hsa047401.73766104
17Vitamin B6 metabolism_Homo sapiens_hsa007501.71858538
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70097686
19Sulfur metabolism_Homo sapiens_hsa009201.64343881
20Type I diabetes mellitus_Homo sapiens_hsa049401.64026288
21B cell receptor signaling pathway_Homo sapiens_hsa046621.47860889
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.46378398
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29494712
24Tryptophan metabolism_Homo sapiens_hsa003801.28261354
25Staphylococcus aureus infection_Homo sapiens_hsa051501.22012589
26Fat digestion and absorption_Homo sapiens_hsa049751.20669057
27N-Glycan biosynthesis_Homo sapiens_hsa005101.18589740
28One carbon pool by folate_Homo sapiens_hsa006701.15775191
29Antigen processing and presentation_Homo sapiens_hsa046121.11426348
30Butanoate metabolism_Homo sapiens_hsa006501.09261767
31RNA polymerase_Homo sapiens_hsa030201.07969901
32Phototransduction_Homo sapiens_hsa047441.05923704
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02965245
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98964517
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95976134
36Hematopoietic cell lineage_Homo sapiens_hsa046400.91679176
37Protein digestion and absorption_Homo sapiens_hsa049740.91553016
38Propanoate metabolism_Homo sapiens_hsa006400.91474861
39Nitrogen metabolism_Homo sapiens_hsa009100.90664444
40Proteasome_Homo sapiens_hsa030500.90087623
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89840034
42NF-kappa B signaling pathway_Homo sapiens_hsa040640.85856490
43Viral myocarditis_Homo sapiens_hsa054160.85024283
44Linoleic acid metabolism_Homo sapiens_hsa005910.84375269
45Osteoclast differentiation_Homo sapiens_hsa043800.84335992
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83635916
47Leishmaniasis_Homo sapiens_hsa051400.82976493
48Caffeine metabolism_Homo sapiens_hsa002320.82452963
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80962207
50Other glycan degradation_Homo sapiens_hsa005110.80317903
51Rheumatoid arthritis_Homo sapiens_hsa053230.79323962
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.72559241
53Influenza A_Homo sapiens_hsa051640.70379332
54Homologous recombination_Homo sapiens_hsa034400.69171149
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.68294420
56Systemic lupus erythematosus_Homo sapiens_hsa053220.67424037
57FoxO signaling pathway_Homo sapiens_hsa040680.64717015
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63669142
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62338703
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61768441
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61377837
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61304899
63Legionellosis_Homo sapiens_hsa051340.61199189
64beta-Alanine metabolism_Homo sapiens_hsa004100.60675242
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59823238
66Herpes simplex infection_Homo sapiens_hsa051680.59096582
67Toxoplasmosis_Homo sapiens_hsa051450.57148479
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53129502
69Glycerolipid metabolism_Homo sapiens_hsa005610.52871969
70Tuberculosis_Homo sapiens_hsa051520.50246753
71Ether lipid metabolism_Homo sapiens_hsa005650.50017027
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45579599
73T cell receptor signaling pathway_Homo sapiens_hsa046600.44620518
74TNF signaling pathway_Homo sapiens_hsa046680.44310340
75Epstein-Barr virus infection_Homo sapiens_hsa051690.43819014
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43715624
77Chemical carcinogenesis_Homo sapiens_hsa052040.43591346
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41875594
79Sphingolipid metabolism_Homo sapiens_hsa006000.40538444
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40405048
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39710122
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39071465
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38361807
84mTOR signaling pathway_Homo sapiens_hsa041500.36849659
85Thyroid hormone synthesis_Homo sapiens_hsa049180.36539567
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36144473
87Selenocompound metabolism_Homo sapiens_hsa004500.34752064
88Fructose and mannose metabolism_Homo sapiens_hsa000510.34602909
89Vitamin digestion and absorption_Homo sapiens_hsa049770.34271017
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33978061
91Serotonergic synapse_Homo sapiens_hsa047260.31184363
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30474970
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29450546
94Arginine biosynthesis_Homo sapiens_hsa002200.28628856
95Chemokine signaling pathway_Homo sapiens_hsa040620.27659024
96Fatty acid degradation_Homo sapiens_hsa000710.27092646
97Taste transduction_Homo sapiens_hsa047420.26837410
98Salivary secretion_Homo sapiens_hsa049700.26348927
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25563684
100Cholinergic synapse_Homo sapiens_hsa047250.23807823

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