MTND5P24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)7.08828336
2microglial cell activation (GO:0001774)6.27217101
3positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)6.16439194
4positive regulation of gamma-delta T cell activation (GO:0046645)5.98309799
5regulation of B cell receptor signaling pathway (GO:0050855)5.77519342
6positive regulation by symbiont of host defense response (GO:0052509)5.70240873
7modulation by symbiont of host defense response (GO:0052031)5.70240873
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.70240873
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.70240873
10positive regulation by organism of defense response of other organism involved in symbiotic interact5.70240873
11modulation by symbiont of host immune response (GO:0052553)5.70240873
12negative regulation of cell killing (GO:0031342)5.14414860
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.14414860
14negative regulation of amyloid precursor protein catabolic process (GO:1902992)5.12969320
15positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.08558984
16macrophage activation (GO:0042116)4.97749848
17neutrophil mediated immunity (GO:0002446)4.92110230
18hepatocyte apoptotic process (GO:0097284)4.89627946
19regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.88672490
20regulation of gamma-delta T cell differentiation (GO:0045586)4.75414284
21macrophage activation involved in immune response (GO:0002281)4.65641063
22detection of external biotic stimulus (GO:0098581)4.51011909
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.49450791
24regulation of gamma-delta T cell activation (GO:0046643)4.46329808
25regulation of protein polyubiquitination (GO:1902914)4.42281059
26myeloid leukocyte mediated immunity (GO:0002444)4.40271408
27regulation of interferon-beta biosynthetic process (GO:0045357)4.40245438
28cellular extravasation (GO:0045123)4.39942421
29dosage compensation (GO:0007549)4.32389228
30regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.26202642
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.21524022
32negative regulation of B cell proliferation (GO:0030889)4.03259487
33histone mRNA catabolic process (GO:0071044)3.99527536
34regulation of beta-amyloid formation (GO:1902003)3.94221574
35positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.93411944
36detection of biotic stimulus (GO:0009595)3.91814882
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.86164633
38response to host immune response (GO:0052572)3.86164633
39B cell receptor signaling pathway (GO:0050853)3.84392374
40negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.80118518
41positive T cell selection (GO:0043368)3.78240552
42negative T cell selection (GO:0043383)3.78172915
43negative regulation of immunoglobulin mediated immune response (GO:0002890)3.73380298
44negative regulation of B cell mediated immunity (GO:0002713)3.73380298
45negative thymic T cell selection (GO:0045060)3.67288350
46negative regulation of lymphocyte mediated immunity (GO:0002707)3.64088370
47phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.59598367
48positive thymic T cell selection (GO:0045059)3.52928569
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.50933173
50response to host (GO:0075136)3.50933173
51response to host defenses (GO:0052200)3.50933173
52regulation of interleukin-12 biosynthetic process (GO:0045075)3.50592426
53negative regulation of T cell mediated immunity (GO:0002710)3.50264639
54regulation of interleukin-6 biosynthetic process (GO:0045408)3.49708973
55monoubiquitinated protein deubiquitination (GO:0035520)3.46842566
56negative regulation of complement activation (GO:0045916)3.46398534
57regulation of necroptotic process (GO:0060544)3.45794004
58neural tube formation (GO:0001841)3.44989214
59negative regulation of interleukin-12 production (GO:0032695)3.44191547
60detection of other organism (GO:0098543)3.40548274
61histone H3-K36 demethylation (GO:0070544)3.40499017
62T-helper 1 type immune response (GO:0042088)3.39088018
63production of molecular mediator involved in inflammatory response (GO:0002532)3.31744775
64negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.26038657
65iron ion import (GO:0097286)3.20803069
66regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.20243142
67establishment of protein localization to Golgi (GO:0072600)3.18969097
68pantothenate metabolic process (GO:0015939)3.16372880
69regulation of amyloid precursor protein catabolic process (GO:1902991)3.16309107
70interferon-gamma production (GO:0032609)3.15498541
71response to interleukin-15 (GO:0070672)3.10735662
72myeloid cell activation involved in immune response (GO:0002275)3.09791985
73protein K11-linked deubiquitination (GO:0035871)3.08652568
74protein targeting to Golgi (GO:0000042)3.06941494
75determination of adult lifespan (GO:0008340)3.06456988
76negative regulation of adaptive immune response (GO:0002820)3.04610049
77negative regulation of protein activation cascade (GO:2000258)3.03946543
78positive regulation of granulocyte differentiation (GO:0030854)3.03139703
79negative regulation of humoral immune response (GO:0002921)3.01962957
80respiratory burst (GO:0045730)3.01723435
81neutrophil activation involved in immune response (GO:0002283)2.99365172
82defense response to protozoan (GO:0042832)2.99157020
83positive regulation of interferon-alpha production (GO:0032727)2.95238831
84regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.91112282
85positive regulation of response to oxidative stress (GO:1902884)2.90858544
86positive regulation of cellular response to oxidative stress (GO:1900409)2.90858544
87regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.90128222
88cellular response to epinephrine stimulus (GO:0071872)2.89009038
89retrograde transport, vesicle recycling within Golgi (GO:0000301)2.87323575
90cellular response to interleukin-15 (GO:0071350)2.86803404
91negative regulation of leukocyte mediated immunity (GO:0002704)2.84605920
92positive regulation of insulin receptor signaling pathway (GO:0046628)2.82482268
93positive regulation of receptor recycling (GO:0001921)2.79568423
94neutrophil activation (GO:0042119)2.78936298
95regulation of B cell differentiation (GO:0045577)2.77203911
96mitochondrion distribution (GO:0048311)2.76680384
97negative regulation of cAMP-mediated signaling (GO:0043951)2.75380549
98dendritic cell migration (GO:0036336)2.74690112
99response to manganese ion (GO:0010042)2.74144314
100regulation of B cell proliferation (GO:0030888)2.73223809

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.90561285
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.38526352
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.81174845
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.60274738
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.38546005
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.03405182
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.99026068
8RUNX_20019798_ChIP-Seq_JUKART_Human2.97547317
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.73139873
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.70153866
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.67733151
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51740902
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.48764623
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36302729
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.35282158
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.27156905
17SCL_19346495_ChIP-Seq_HPC-7_Human2.17865735
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07869345
19MYB_26560356_Chip-Seq_TH2_Human2.03805893
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93836374
21VDR_24787735_ChIP-Seq_THP-1_Human1.92077966
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90053230
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83553111
24SPI1_23547873_ChIP-Seq_NB4_Human1.67400702
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.64213375
26SPI1_23127762_ChIP-Seq_K562_Human1.61970300
27MYB_26560356_Chip-Seq_TH1_Human1.58767745
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.56996867
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.56086159
30GATA3_27048872_Chip-Seq_THYMUS_Human1.55405737
31PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55222372
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50649921
33TP53_16413492_ChIP-PET_HCT116_Human1.49824586
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48857482
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48677205
36GATA3_26560356_Chip-Seq_TH2_Human1.47295415
37GATA1_22025678_ChIP-Seq_K562_Human1.45103003
38PU_27001747_Chip-Seq_BMDM_Mouse1.43946578
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42188010
40SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34369752
41GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33770144
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32388437
43ER_23166858_ChIP-Seq_MCF-7_Human1.32077507
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31806149
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30593070
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.28260803
47CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25903426
48RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24873250
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24608967
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.24423911
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24111928
52KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.24014321
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22409823
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22123537
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.21484771
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21035938
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.19928581
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17938809
59GATA2_19941826_ChIP-Seq_K562_Human1.17926535
60FLI1_21867929_ChIP-Seq_TH2_Mouse1.16627844
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.13932591
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11208056
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11208056
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.11112038
65TAF15_26573619_Chip-Seq_HEK293_Human1.10265804
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08175442
67FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08172346
68GATA1_19941827_ChIP-Seq_MEL86_Mouse1.07618121
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.05478395
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04891568
71OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04553438
72CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04495582
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03906727
74NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03512648
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.02108288
76GATA1_19941826_ChIP-Seq_K562_Human1.01524024
77VDR_24763502_ChIP-Seq_THP-1_Human1.00546852
78SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00476188
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.00258374
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99923146
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99082123
82NANOG_18555785_Chip-Seq_ESCs_Mouse0.98983230
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98178880
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98009853
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96951168
86AR_21572438_ChIP-Seq_LNCaP_Human0.96863850
87E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96690273
88SMRT_27268052_Chip-Seq_Bcells_Human0.96110846
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96004082
90CMYC_18555785_Chip-Seq_ESCs_Mouse0.95262046
91SALL4_22934838_ChIP-ChIP_CD34+_Human0.92477462
92STAT3_23295773_ChIP-Seq_U87_Human0.91232677
93E2F1_18555785_Chip-Seq_ESCs_Mouse0.91061464
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89840264
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89829630
96MAF_26560356_Chip-Seq_TH1_Human0.89158513
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.88175831
98TP63_23658742_ChIP-Seq_EP156T_Human0.87879541
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86165425
100SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85909592

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.68617688
2MP0003724_increased_susceptibility_to4.75822682
3MP0008260_abnormal_autophagy4.37265660
4MP0003787_abnormal_imprinting4.19182503
5MP0005451_abnormal_body_composition3.11570542
6MP0008877_abnormal_DNA_methylation3.07564050
7MP0004381_abnormal_hair_follicle2.86367679
8MP0001835_abnormal_antigen_presentation2.80187253
9MP0003303_peritoneal_inflammation2.69415997
10MP0004883_abnormal_blood_vessel2.61344864
11MP0002166_altered_tumor_susceptibility2.51275592
12MP0003656_abnormal_erythrocyte_physiolo2.48776445
13MP0008057_abnormal_DNA_replication2.29768749
14MP0001800_abnormal_humoral_immune2.27847715
15MP0000015_abnormal_ear_pigmentation2.26334601
16MP0003763_abnormal_thymus_physiology2.22882318
17MP0003172_abnormal_lysosome_physiology2.19764318
18MP0005174_abnormal_tail_pigmentation2.18835004
19MP0003221_abnormal_cardiomyocyte_apopto1.94881671
20MP0002419_abnormal_innate_immunity1.92443975
21MP0002723_abnormal_immune_serum1.83476174
22MP0005164_abnormal_response_to1.81139908
23MP0005671_abnormal_response_to1.77784740
24MP0000685_abnormal_immune_system1.77384474
25MP0002006_tumorigenesis1.76370653
26MP0005075_abnormal_melanosome_morpholog1.73459219
27MP0003436_decreased_susceptibility_to1.71877712
28MP0002452_abnormal_antigen_presenting1.71220605
29MP0002420_abnormal_adaptive_immunity1.69787492
30MP0001819_abnormal_immune_cell1.67397610
31MP0003828_pulmonary_edema1.62981489
32MP0005025_abnormal_response_to1.61425119
33MP0003121_genomic_imprinting1.60334558
34MP0009785_altered_susceptibility_to1.57641526
35MP0002332_abnormal_exercise_endurance1.57156175
36MP0005000_abnormal_immune_tolerance1.56600433
37MP0004484_altered_response_of1.54346453
38MP0002009_preneoplasia1.53549408
39MP0002398_abnormal_bone_marrow1.51315831
40MP0002396_abnormal_hematopoietic_system1.48150277
41MP0000716_abnormal_immune_system1.43561069
42MP0002405_respiratory_system_inflammati1.43074442
43MP0002722_abnormal_immune_system1.37295408
44MP0000703_abnormal_thymus_morphology1.36843680
45MP0005464_abnormal_platelet_physiology1.36560957
46MP0002132_abnormal_respiratory_system1.36542550
47MP0009764_decreased_sensitivity_to1.32955919
48MP0000689_abnormal_spleen_morphology1.32786805
49MP0003690_abnormal_glial_cell1.30759998
50MP0006082_CNS_inflammation1.30296532
51MP0005310_abnormal_salivary_gland1.30056008
52MP0001545_abnormal_hematopoietic_system1.29665857
53MP0005397_hematopoietic_system_phenotyp1.29665857
54MP0004130_abnormal_muscle_cell1.28616243
55MP0003300_gastrointestinal_ulcer1.22831713
56MP0001851_eye_inflammation1.20759479
57MP0001790_abnormal_immune_system1.18911361
58MP0005387_immune_system_phenotype1.18911361
59MP0003195_calcinosis1.17095192
60MP0005408_hypopigmentation1.14201589
61MP0004808_abnormal_hematopoietic_stem1.12671483
62MP0002909_abnormal_adrenal_gland1.11959333
63MP0004947_skin_inflammation1.10413549
64MP0002429_abnormal_blood_cell1.09141518
65MP0000465_gastrointestinal_hemorrhage1.09045323
66MP0001845_abnormal_inflammatory_respons1.08397986
67MP0003866_abnormal_defecation1.04784380
68MP0000427_abnormal_hair_cycle1.04562982
69MP0003183_abnormal_peptide_metabolism1.04543947
70MP0001533_abnormal_skeleton_physiology1.02620774
71MP0000604_amyloidosis1.01824250
72MP0000858_altered_metastatic_potential1.01607202
73MP0009278_abnormal_bone_marrow1.01259503
74MP0002277_abnormal_respiratory_mucosa1.00374376
75MP0005376_homeostasis/metabolism_phenot0.99725324
76MP0003632_abnormal_nervous_system0.93996114
77MP0003329_amyloid_beta_deposits0.92355252
78MP0002148_abnormal_hypersensitivity_rea0.90877688
79MP0003091_abnormal_cell_migration0.87489635
80MP0001958_emphysema0.87370271
81MP0006054_spinal_hemorrhage0.80715633
82MP0000371_diluted_coat_color0.77910579
83MP0000249_abnormal_blood_vessel0.75220747
84MP0005266_abnormal_metabolism0.73430759
85MP0002998_abnormal_bone_remodeling0.71947023
86MP0008874_decreased_physiological_sensi0.67880322
87MP0008469_abnormal_protein_level0.66213585
88MP0003448_altered_tumor_morphology0.65531809
89MP0002928_abnormal_bile_duct0.65363789
90MP0003191_abnormal_cellular_cholesterol0.62083027
91MP0010155_abnormal_intestine_physiology0.61265928
92MP0002133_abnormal_respiratory_system0.59487905
93MP0005388_respiratory_system_phenotype0.59487905
94MP0001440_abnormal_grooming_behavior0.57503480
95MP0009765_abnormal_xenobiotic_induced0.57429689
96MP0002019_abnormal_tumor_incidence0.55664276
97MP0003075_altered_response_to0.54558681
98MP0005409_darkened_coat_color0.54335013
99MP0002095_abnormal_skin_pigmentation0.51155691
100MP0005621_abnormal_cell_physiology0.50031115

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)7.14917250
2Recurrent bacterial skin infections (HP:0005406)6.16279270
3T lymphocytopenia (HP:0005403)5.69944808
4Abnormality of T cell number (HP:0011839)5.34563197
5Recurrent abscess formation (HP:0002722)5.16397547
6Optic neuritis (HP:0100653)5.08199308
7Retrobulbar optic neuritis (HP:0100654)5.08199308
8Orchitis (HP:0100796)4.69616740
9Gastrointestinal infarctions (HP:0005244)4.56746003
10Myositis (HP:0100614)4.42969563
11Eczematoid dermatitis (HP:0000976)4.31123506
12Peritonitis (HP:0002586)4.10367525
13Subacute progressive viral hepatitis (HP:0006572)4.08157085
14Abnormality of macrophages (HP:0004311)3.92218015
15Gingival bleeding (HP:0000225)3.90653175
16Keratoconjunctivitis sicca (HP:0001097)3.85710377
17Recurrent fungal infections (HP:0002841)3.80992882
18Gingivitis (HP:0000230)3.72817924
19Arterial thrombosis (HP:0004420)3.69458197
20Postural instability (HP:0002172)3.69359167
21Recurrent skin infections (HP:0001581)3.67645718
22Keratoconjunctivitis (HP:0001096)3.54728856
23Papillary thyroid carcinoma (HP:0002895)3.48403097
24Resting tremor (HP:0002322)3.46626292
25Recurrent gram-negative bacterial infections (HP:0005420)3.40412254
26Stomatitis (HP:0010280)3.30121218
27Abnormality of T cells (HP:0002843)3.22467382
28Pelvic girdle muscle weakness (HP:0003749)3.15013216
29Spontaneous hematomas (HP:0007420)3.14411735
30Elevated erythrocyte sedimentation rate (HP:0003565)3.08925678
31Visual hallucinations (HP:0002367)2.98760332
32Recurrent cutaneous fungal infections (HP:0011370)2.96532627
33Chronic mucocutaneous candidiasis (HP:0002728)2.96532627
34Encephalitis (HP:0002383)2.95802910
35Viral hepatitis (HP:0006562)2.92569663
36Chest pain (HP:0100749)2.78991588
37Leukocytosis (HP:0001974)2.77406968
38Abnormality of the hip-girdle musculature (HP:0001445)2.69568921
39Abnormality of the musculature of the pelvis (HP:0001469)2.69568921
40Slow saccadic eye movements (HP:0000514)2.67154583
41Conjunctival telangiectasia (HP:0000524)2.65997142
42Genetic anticipation (HP:0003743)2.64845293
43Periodontitis (HP:0000704)2.64200473
44Thyroiditis (HP:0100646)2.64178685
45Abnormal delayed hypersensitivity skin test (HP:0002963)2.64085945
46Mediastinal lymphadenopathy (HP:0100721)2.63788654
47Abnormality of the vasculature of the conjunctiva (HP:0008054)2.63454475
48Anorexia (HP:0002039)2.60809655
49Hemoptysis (HP:0002105)2.59194064
50Recurrent viral infections (HP:0004429)2.52206994
51Meningitis (HP:0001287)2.49998240
52Vasculitis (HP:0002633)2.47646405
53Urticaria (HP:0001025)2.46665772
54Epistaxis (HP:0000421)2.42727085
55Pulmonary embolism (HP:0002204)2.42364167
56Eosinophilia (HP:0001880)2.42215332
57Recurrent bronchitis (HP:0002837)2.41360220
58Thyroid carcinoma (HP:0002890)2.39491734
59Gangrene (HP:0100758)2.39356406
60Abnormality of the peritoneum (HP:0002585)2.35657339
61Acute hepatic failure (HP:0006554)2.32334787
62Abnormality of the common coagulation pathway (HP:0010990)2.24969721
63Abnormality of eosinophils (HP:0001879)2.22480434
64Stomach cancer (HP:0012126)2.22153995
65Hypoplasia of the thymus (HP:0000778)2.21558653
66Hepatitis (HP:0012115)2.19353527
67IgA deficiency (HP:0002720)2.17307585
68Obstructive lung disease (HP:0006536)2.14681253
69Chronic obstructive pulmonary disease (HP:0006510)2.14681253
70Neoplasm of the tracheobronchial system (HP:0100552)2.09860840
71Cellular immunodeficiency (HP:0005374)2.09653528
72Micronodular cirrhosis (HP:0001413)2.08781902
73Abnormality of the endocardium (HP:0004306)2.07723870
74Neurodegeneration (HP:0002180)2.06636828
75IgM deficiency (HP:0002850)2.05805851
76Episodic fever (HP:0001954)2.05138770
77Pulmonary infiltrates (HP:0002113)2.04481614
78Orthostatic hypotension (HP:0001278)2.01372653
79Inflammation of the large intestine (HP:0002037)1.97149035
80Cellulitis (HP:0100658)1.95585572
81Increased serum ferritin (HP:0003281)1.95105628
82Granulocytopenia (HP:0001913)1.93433310
83Hemiplegia (HP:0002301)1.93216724
84Poikilocytosis (HP:0004447)1.92003906
85Autoimmune hemolytic anemia (HP:0001890)1.89849524
86Prolonged bleeding time (HP:0003010)1.89162019
87Colitis (HP:0002583)1.88807979
88Foot dorsiflexor weakness (HP:0009027)1.87990965
89Aplasia/Hypoplasia of the macula (HP:0008059)1.87400985
90Mask-like facies (HP:0000298)1.84318587
91Facial diplegia (HP:0001349)1.83816194
92Tinnitus (HP:0000360)1.82297037
93Keratitis (HP:0000491)1.80282827
94Verrucae (HP:0200043)1.79595367
95Papilloma (HP:0012740)1.79595367
96Myocardial infarction (HP:0001658)1.79195220
97Vertigo (HP:0002321)1.77250627
98Acute myeloid leukemia (HP:0004808)1.75783165
99Thrombophlebitis (HP:0004418)1.73869148
100Abnormality of the fingertips (HP:0001211)1.72785423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.81871864
2RIPK43.47411684
3BLK3.38049573
4GRK62.72175344
5IRAK42.67979015
6FGR2.65335189
7MAP3K22.62196232
8IRAK12.47259956
9IRAK22.37456462
10TAOK32.34432976
11CSK2.27828380
12IKBKE2.26876931
13WNK12.14270994
14TXK2.12052282
15YES11.93908231
16PTK2B1.90857327
17MAP2K31.82891876
18PIK3CG1.82377298
19JAK31.80667503
20SYK1.77101771
21FGFR31.77048394
22FES1.74874625
23GRK51.68920515
24BMPR21.65653695
25STK41.62790810
26PLK21.51298997
27SGK21.50029506
28PAK31.43847804
29BTK1.40966293
30TYK21.35404874
31MAP4K11.32386098
32ERBB21.31259266
33MAP3K141.29112804
34LRRK21.26858679
35JAK11.21286242
36ACVR1B1.20121760
37TEC1.18649522
38HCK1.17820837
39JAK21.17774970
40KSR21.16896185
41CAMKK21.13256836
42LYN1.12369187
43MAP3K11.10915152
44PIM11.08770414
45KSR11.08760625
46STK111.06973251
47ITK1.04529979
48RAF11.04494328
49ZAP701.03744682
50SGK31.03219885
51DYRK1A1.02870910
52MAP3K60.94982952
53NEK60.94128851
54MARK20.92434418
55NLK0.92036603
56EPHB10.90121808
57SGK2230.86949514
58SGK4940.86949514
59LCK0.86653760
60MARK30.84929156
61MATK0.84297945
62TGFBR20.75160114
63SGK10.68926204
64DYRK1B0.66322069
65TRPM70.65605277
66RPS6KB20.65084948
67MAP3K50.63954444
68FGFR20.61490126
69DMPK0.61354397
70MAP2K40.60804343
71ADRBK10.60411420
72EGFR0.60308597
73DYRK30.57582766
74TAOK10.56215817
75PDK10.56214758
76IKBKB0.55356092
77STK380.55293986
78CAMK40.54091874
79CDK120.53463894
80MAP3K30.51733289
81KIT0.51287410
82AKT30.50071547
83PDGFRB0.49378184
84MAP3K130.47486766
85CSF1R0.46202472
86CLK10.44530160
87NUAK10.43955059
88MAP2K60.42409894
89MAP3K110.42294939
90WNK30.41701543
91TBK10.41554586
92CHUK0.41204154
93CAMK1D0.39739623
94RET0.38550180
95MELK0.38099197
96CAMKK10.36893811
97FYN0.35224203
98NTRK30.33395761
99HIPK20.33249210
100STK100.32912284

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.85288326
2B cell receptor signaling pathway_Homo sapiens_hsa046622.53233765
3Osteoclast differentiation_Homo sapiens_hsa043802.36630742
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.35695350
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.31762981
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.27446228
7Non-small cell lung cancer_Homo sapiens_hsa052232.13728645
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.12383868
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.07633923
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.03241143
11Tuberculosis_Homo sapiens_hsa051521.93402258
12T cell receptor signaling pathway_Homo sapiens_hsa046601.89844442
13Dorso-ventral axis formation_Homo sapiens_hsa043201.75335589
14Measles_Homo sapiens_hsa051621.71124459
15Legionellosis_Homo sapiens_hsa051341.70317167
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65949562
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64186930
18Staphylococcus aureus infection_Homo sapiens_hsa051501.62522143
19Malaria_Homo sapiens_hsa051441.56872615
20Toxoplasmosis_Homo sapiens_hsa051451.49647859
21FoxO signaling pathway_Homo sapiens_hsa040681.49022400
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.45595551
23Hepatitis B_Homo sapiens_hsa051611.43330689
24Acute myeloid leukemia_Homo sapiens_hsa052211.40752693
25Prolactin signaling pathway_Homo sapiens_hsa049171.40290135
26Platelet activation_Homo sapiens_hsa046111.39098121
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36647178
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36412123
29Chemokine signaling pathway_Homo sapiens_hsa040621.35489396
30TNF signaling pathway_Homo sapiens_hsa046681.35096095
31Primary immunodeficiency_Homo sapiens_hsa053401.31964984
32Apoptosis_Homo sapiens_hsa042101.30550569
33Influenza A_Homo sapiens_hsa051641.26759871
34Hematopoietic cell lineage_Homo sapiens_hsa046401.26662586
35Renal cell carcinoma_Homo sapiens_hsa052111.25780960
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22654257
37VEGF signaling pathway_Homo sapiens_hsa043701.22161075
38Chronic myeloid leukemia_Homo sapiens_hsa052201.18269925
39Pancreatic cancer_Homo sapiens_hsa052121.18180354
40Graft-versus-host disease_Homo sapiens_hsa053321.13468839
41Inositol phosphate metabolism_Homo sapiens_hsa005621.11589467
42mTOR signaling pathway_Homo sapiens_hsa041501.11476934
43Endometrial cancer_Homo sapiens_hsa052131.09436194
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.07244508
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.07116317
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05149376
47Hepatitis C_Homo sapiens_hsa051601.03415980
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00590381
49ErbB signaling pathway_Homo sapiens_hsa040121.00571084
50Glioma_Homo sapiens_hsa052140.97129023
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89426069
52HIF-1 signaling pathway_Homo sapiens_hsa040660.89176522
53Small cell lung cancer_Homo sapiens_hsa052220.85560161
54Choline metabolism in cancer_Homo sapiens_hsa052310.84600009
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80176958
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.78688788
57Herpes simplex infection_Homo sapiens_hsa051680.76896655
58Prostate cancer_Homo sapiens_hsa052150.75591431
59Notch signaling pathway_Homo sapiens_hsa043300.74143554
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73023249
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72598952
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72338210
63Phagosome_Homo sapiens_hsa041450.70724780
64Fatty acid biosynthesis_Homo sapiens_hsa000610.70008778
65GnRH signaling pathway_Homo sapiens_hsa049120.69615041
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69344668
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.67753367
68MAPK signaling pathway_Homo sapiens_hsa040100.66750887
69Allograft rejection_Homo sapiens_hsa053300.65620093
70MicroRNAs in cancer_Homo sapiens_hsa052060.65065419
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64620435
72Long-term potentiation_Homo sapiens_hsa047200.64068567
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64052856
74Antigen processing and presentation_Homo sapiens_hsa046120.62647189
75Autoimmune thyroid disease_Homo sapiens_hsa053200.62352563
76Insulin resistance_Homo sapiens_hsa049310.61278596
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59816058
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.58783304
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57932622
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56839275
81Nitrogen metabolism_Homo sapiens_hsa009100.55484212
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54352530
83Amoebiasis_Homo sapiens_hsa051460.53270032
84Viral carcinogenesis_Homo sapiens_hsa052030.52545474
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52440310
86Type II diabetes mellitus_Homo sapiens_hsa049300.52298752
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52191639
88Pertussis_Homo sapiens_hsa051330.52145133
89Cholinergic synapse_Homo sapiens_hsa047250.51691692
90African trypanosomiasis_Homo sapiens_hsa051430.50511918
91Proteoglycans in cancer_Homo sapiens_hsa052050.50475462
92Long-term depression_Homo sapiens_hsa047300.49204735
93Salmonella infection_Homo sapiens_hsa051320.48331237
94p53 signaling pathway_Homo sapiens_hsa041150.46786802
95Oxytocin signaling pathway_Homo sapiens_hsa049210.46411266
96Thyroid cancer_Homo sapiens_hsa052160.43372585
97Colorectal cancer_Homo sapiens_hsa052100.43359348
98Estrogen signaling pathway_Homo sapiens_hsa049150.42438925
99Ras signaling pathway_Homo sapiens_hsa040140.41695846
100cAMP signaling pathway_Homo sapiens_hsa040240.41439566

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