

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | detection of molecule of bacterial origin (GO:0032490) | 7.08828336 |
| 2 | microglial cell activation (GO:0001774) | 6.27217101 |
| 3 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 6.16439194 |
| 4 | positive regulation of gamma-delta T cell activation (GO:0046645) | 5.98309799 |
| 5 | regulation of B cell receptor signaling pathway (GO:0050855) | 5.77519342 |
| 6 | positive regulation by symbiont of host defense response (GO:0052509) | 5.70240873 |
| 7 | modulation by symbiont of host defense response (GO:0052031) | 5.70240873 |
| 8 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 5.70240873 |
| 9 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 5.70240873 |
| 10 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 5.70240873 |
| 11 | modulation by symbiont of host immune response (GO:0052553) | 5.70240873 |
| 12 | negative regulation of cell killing (GO:0031342) | 5.14414860 |
| 13 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 5.14414860 |
| 14 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 5.12969320 |
| 15 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 5.08558984 |
| 16 | macrophage activation (GO:0042116) | 4.97749848 |
| 17 | neutrophil mediated immunity (GO:0002446) | 4.92110230 |
| 18 | hepatocyte apoptotic process (GO:0097284) | 4.89627946 |
| 19 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 4.88672490 |
| 20 | regulation of gamma-delta T cell differentiation (GO:0045586) | 4.75414284 |
| 21 | macrophage activation involved in immune response (GO:0002281) | 4.65641063 |
| 22 | detection of external biotic stimulus (GO:0098581) | 4.51011909 |
| 23 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 4.49450791 |
| 24 | regulation of gamma-delta T cell activation (GO:0046643) | 4.46329808 |
| 25 | regulation of protein polyubiquitination (GO:1902914) | 4.42281059 |
| 26 | myeloid leukocyte mediated immunity (GO:0002444) | 4.40271408 |
| 27 | regulation of interferon-beta biosynthetic process (GO:0045357) | 4.40245438 |
| 28 | cellular extravasation (GO:0045123) | 4.39942421 |
| 29 | dosage compensation (GO:0007549) | 4.32389228 |
| 30 | regulation of nitric-oxide synthase biosynthetic process (GO:0051769) | 4.26202642 |
| 31 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.21524022 |
| 32 | negative regulation of B cell proliferation (GO:0030889) | 4.03259487 |
| 33 | histone mRNA catabolic process (GO:0071044) | 3.99527536 |
| 34 | regulation of beta-amyloid formation (GO:1902003) | 3.94221574 |
| 35 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 3.93411944 |
| 36 | detection of biotic stimulus (GO:0009595) | 3.91814882 |
| 37 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.86164633 |
| 38 | response to host immune response (GO:0052572) | 3.86164633 |
| 39 | B cell receptor signaling pathway (GO:0050853) | 3.84392374 |
| 40 | negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642) | 3.80118518 |
| 41 | positive T cell selection (GO:0043368) | 3.78240552 |
| 42 | negative T cell selection (GO:0043383) | 3.78172915 |
| 43 | negative regulation of immunoglobulin mediated immune response (GO:0002890) | 3.73380298 |
| 44 | negative regulation of B cell mediated immunity (GO:0002713) | 3.73380298 |
| 45 | negative thymic T cell selection (GO:0045060) | 3.67288350 |
| 46 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.64088370 |
| 47 | phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) | 3.59598367 |
| 48 | positive thymic T cell selection (GO:0045059) | 3.52928569 |
| 49 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.50933173 |
| 50 | response to host (GO:0075136) | 3.50933173 |
| 51 | response to host defenses (GO:0052200) | 3.50933173 |
| 52 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.50592426 |
| 53 | negative regulation of T cell mediated immunity (GO:0002710) | 3.50264639 |
| 54 | regulation of interleukin-6 biosynthetic process (GO:0045408) | 3.49708973 |
| 55 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.46842566 |
| 56 | negative regulation of complement activation (GO:0045916) | 3.46398534 |
| 57 | regulation of necroptotic process (GO:0060544) | 3.45794004 |
| 58 | neural tube formation (GO:0001841) | 3.44989214 |
| 59 | negative regulation of interleukin-12 production (GO:0032695) | 3.44191547 |
| 60 | detection of other organism (GO:0098543) | 3.40548274 |
| 61 | histone H3-K36 demethylation (GO:0070544) | 3.40499017 |
| 62 | T-helper 1 type immune response (GO:0042088) | 3.39088018 |
| 63 | production of molecular mediator involved in inflammatory response (GO:0002532) | 3.31744775 |
| 64 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 3.26038657 |
| 65 | iron ion import (GO:0097286) | 3.20803069 |
| 66 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 3.20243142 |
| 67 | establishment of protein localization to Golgi (GO:0072600) | 3.18969097 |
| 68 | pantothenate metabolic process (GO:0015939) | 3.16372880 |
| 69 | regulation of amyloid precursor protein catabolic process (GO:1902991) | 3.16309107 |
| 70 | interferon-gamma production (GO:0032609) | 3.15498541 |
| 71 | response to interleukin-15 (GO:0070672) | 3.10735662 |
| 72 | myeloid cell activation involved in immune response (GO:0002275) | 3.09791985 |
| 73 | protein K11-linked deubiquitination (GO:0035871) | 3.08652568 |
| 74 | protein targeting to Golgi (GO:0000042) | 3.06941494 |
| 75 | determination of adult lifespan (GO:0008340) | 3.06456988 |
| 76 | negative regulation of adaptive immune response (GO:0002820) | 3.04610049 |
| 77 | negative regulation of protein activation cascade (GO:2000258) | 3.03946543 |
| 78 | positive regulation of granulocyte differentiation (GO:0030854) | 3.03139703 |
| 79 | negative regulation of humoral immune response (GO:0002921) | 3.01962957 |
| 80 | respiratory burst (GO:0045730) | 3.01723435 |
| 81 | neutrophil activation involved in immune response (GO:0002283) | 2.99365172 |
| 82 | defense response to protozoan (GO:0042832) | 2.99157020 |
| 83 | positive regulation of interferon-alpha production (GO:0032727) | 2.95238831 |
| 84 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 2.91112282 |
| 85 | positive regulation of response to oxidative stress (GO:1902884) | 2.90858544 |
| 86 | positive regulation of cellular response to oxidative stress (GO:1900409) | 2.90858544 |
| 87 | regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640) | 2.90128222 |
| 88 | cellular response to epinephrine stimulus (GO:0071872) | 2.89009038 |
| 89 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 2.87323575 |
| 90 | cellular response to interleukin-15 (GO:0071350) | 2.86803404 |
| 91 | negative regulation of leukocyte mediated immunity (GO:0002704) | 2.84605920 |
| 92 | positive regulation of insulin receptor signaling pathway (GO:0046628) | 2.82482268 |
| 93 | positive regulation of receptor recycling (GO:0001921) | 2.79568423 |
| 94 | neutrophil activation (GO:0042119) | 2.78936298 |
| 95 | regulation of B cell differentiation (GO:0045577) | 2.77203911 |
| 96 | mitochondrion distribution (GO:0048311) | 2.76680384 |
| 97 | negative regulation of cAMP-mediated signaling (GO:0043951) | 2.75380549 |
| 98 | dendritic cell migration (GO:0036336) | 2.74690112 |
| 99 | response to manganese ion (GO:0010042) | 2.74144314 |
| 100 | regulation of B cell proliferation (GO:0030888) | 2.73223809 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.90561285 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 4.38526352 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.81174845 |
| 4 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 3.60274738 |
| 5 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 3.38546005 |
| 6 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.03405182 |
| 7 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.99026068 |
| 8 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.97547317 |
| 9 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.73139873 |
| 10 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.70153866 |
| 11 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.67733151 |
| 12 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.51740902 |
| 13 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.48764623 |
| 14 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.36302729 |
| 15 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.35282158 |
| 16 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.27156905 |
| 17 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.17865735 |
| 18 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.07869345 |
| 19 | MYB_26560356_Chip-Seq_TH2_Human | 2.03805893 |
| 20 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.93836374 |
| 21 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.92077966 |
| 22 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.90053230 |
| 23 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.83553111 |
| 24 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.67400702 |
| 25 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.64213375 |
| 26 | SPI1_23127762_ChIP-Seq_K562_Human | 1.61970300 |
| 27 | MYB_26560356_Chip-Seq_TH1_Human | 1.58767745 |
| 28 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.56996867 |
| 29 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.56086159 |
| 30 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.55405737 |
| 31 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.55222372 |
| 32 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.50649921 |
| 33 | TP53_16413492_ChIP-PET_HCT116_Human | 1.49824586 |
| 34 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.48857482 |
| 35 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.48677205 |
| 36 | GATA3_26560356_Chip-Seq_TH2_Human | 1.47295415 |
| 37 | GATA1_22025678_ChIP-Seq_K562_Human | 1.45103003 |
| 38 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.43946578 |
| 39 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.42188010 |
| 40 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.34369752 |
| 41 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.33770144 |
| 42 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.32388437 |
| 43 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.32077507 |
| 44 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.31806149 |
| 45 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.30593070 |
| 46 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.28260803 |
| 47 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.25903426 |
| 48 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.24873250 |
| 49 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.24608967 |
| 50 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.24423911 |
| 51 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.24111928 |
| 52 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 1.24014321 |
| 53 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.22409823 |
| 54 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.22123537 |
| 55 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.21484771 |
| 56 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.21035938 |
| 57 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.19928581 |
| 58 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.17938809 |
| 59 | GATA2_19941826_ChIP-Seq_K562_Human | 1.17926535 |
| 60 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.16627844 |
| 61 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.13932591 |
| 62 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.11208056 |
| 63 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.11208056 |
| 64 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.11112038 |
| 65 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.10265804 |
| 66 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.08175442 |
| 67 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.08172346 |
| 68 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 1.07618121 |
| 69 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.05478395 |
| 70 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.04891568 |
| 71 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 1.04553438 |
| 72 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.04495582 |
| 73 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.03906727 |
| 74 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.03512648 |
| 75 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.02108288 |
| 76 | GATA1_19941826_ChIP-Seq_K562_Human | 1.01524024 |
| 77 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.00546852 |
| 78 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 1.00476188 |
| 79 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.00258374 |
| 80 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.99923146 |
| 81 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.99082123 |
| 82 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.98983230 |
| 83 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.98178880 |
| 84 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.98009853 |
| 85 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.96951168 |
| 86 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.96863850 |
| 87 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.96690273 |
| 88 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.96110846 |
| 89 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.96004082 |
| 90 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.95262046 |
| 91 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.92477462 |
| 92 | STAT3_23295773_ChIP-Seq_U87_Human | 0.91232677 |
| 93 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.91061464 |
| 94 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.89840264 |
| 95 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.89829630 |
| 96 | MAF_26560356_Chip-Seq_TH1_Human | 0.89158513 |
| 97 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.88175831 |
| 98 | TP63_23658742_ChIP-Seq_EP156T_Human | 0.87879541 |
| 99 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.86165425 |
| 100 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.85909592 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000569_abnormal_digit_pigmentation | 6.68617688 |
| 2 | MP0003724_increased_susceptibility_to | 4.75822682 |
| 3 | MP0008260_abnormal_autophagy | 4.37265660 |
| 4 | MP0003787_abnormal_imprinting | 4.19182503 |
| 5 | MP0005451_abnormal_body_composition | 3.11570542 |
| 6 | MP0008877_abnormal_DNA_methylation | 3.07564050 |
| 7 | MP0004381_abnormal_hair_follicle | 2.86367679 |
| 8 | MP0001835_abnormal_antigen_presentation | 2.80187253 |
| 9 | MP0003303_peritoneal_inflammation | 2.69415997 |
| 10 | MP0004883_abnormal_blood_vessel | 2.61344864 |
| 11 | MP0002166_altered_tumor_susceptibility | 2.51275592 |
| 12 | MP0003656_abnormal_erythrocyte_physiolo | 2.48776445 |
| 13 | MP0008057_abnormal_DNA_replication | 2.29768749 |
| 14 | MP0001800_abnormal_humoral_immune | 2.27847715 |
| 15 | MP0000015_abnormal_ear_pigmentation | 2.26334601 |
| 16 | MP0003763_abnormal_thymus_physiology | 2.22882318 |
| 17 | MP0003172_abnormal_lysosome_physiology | 2.19764318 |
| 18 | MP0005174_abnormal_tail_pigmentation | 2.18835004 |
| 19 | MP0003221_abnormal_cardiomyocyte_apopto | 1.94881671 |
| 20 | MP0002419_abnormal_innate_immunity | 1.92443975 |
| 21 | MP0002723_abnormal_immune_serum | 1.83476174 |
| 22 | MP0005164_abnormal_response_to | 1.81139908 |
| 23 | MP0005671_abnormal_response_to | 1.77784740 |
| 24 | MP0000685_abnormal_immune_system | 1.77384474 |
| 25 | MP0002006_tumorigenesis | 1.76370653 |
| 26 | MP0005075_abnormal_melanosome_morpholog | 1.73459219 |
| 27 | MP0003436_decreased_susceptibility_to | 1.71877712 |
| 28 | MP0002452_abnormal_antigen_presenting | 1.71220605 |
| 29 | MP0002420_abnormal_adaptive_immunity | 1.69787492 |
| 30 | MP0001819_abnormal_immune_cell | 1.67397610 |
| 31 | MP0003828_pulmonary_edema | 1.62981489 |
| 32 | MP0005025_abnormal_response_to | 1.61425119 |
| 33 | MP0003121_genomic_imprinting | 1.60334558 |
| 34 | MP0009785_altered_susceptibility_to | 1.57641526 |
| 35 | MP0002332_abnormal_exercise_endurance | 1.57156175 |
| 36 | MP0005000_abnormal_immune_tolerance | 1.56600433 |
| 37 | MP0004484_altered_response_of | 1.54346453 |
| 38 | MP0002009_preneoplasia | 1.53549408 |
| 39 | MP0002398_abnormal_bone_marrow | 1.51315831 |
| 40 | MP0002396_abnormal_hematopoietic_system | 1.48150277 |
| 41 | MP0000716_abnormal_immune_system | 1.43561069 |
| 42 | MP0002405_respiratory_system_inflammati | 1.43074442 |
| 43 | MP0002722_abnormal_immune_system | 1.37295408 |
| 44 | MP0000703_abnormal_thymus_morphology | 1.36843680 |
| 45 | MP0005464_abnormal_platelet_physiology | 1.36560957 |
| 46 | MP0002132_abnormal_respiratory_system | 1.36542550 |
| 47 | MP0009764_decreased_sensitivity_to | 1.32955919 |
| 48 | MP0000689_abnormal_spleen_morphology | 1.32786805 |
| 49 | MP0003690_abnormal_glial_cell | 1.30759998 |
| 50 | MP0006082_CNS_inflammation | 1.30296532 |
| 51 | MP0005310_abnormal_salivary_gland | 1.30056008 |
| 52 | MP0001545_abnormal_hematopoietic_system | 1.29665857 |
| 53 | MP0005397_hematopoietic_system_phenotyp | 1.29665857 |
| 54 | MP0004130_abnormal_muscle_cell | 1.28616243 |
| 55 | MP0003300_gastrointestinal_ulcer | 1.22831713 |
| 56 | MP0001851_eye_inflammation | 1.20759479 |
| 57 | MP0001790_abnormal_immune_system | 1.18911361 |
| 58 | MP0005387_immune_system_phenotype | 1.18911361 |
| 59 | MP0003195_calcinosis | 1.17095192 |
| 60 | MP0005408_hypopigmentation | 1.14201589 |
| 61 | MP0004808_abnormal_hematopoietic_stem | 1.12671483 |
| 62 | MP0002909_abnormal_adrenal_gland | 1.11959333 |
| 63 | MP0004947_skin_inflammation | 1.10413549 |
| 64 | MP0002429_abnormal_blood_cell | 1.09141518 |
| 65 | MP0000465_gastrointestinal_hemorrhage | 1.09045323 |
| 66 | MP0001845_abnormal_inflammatory_respons | 1.08397986 |
| 67 | MP0003866_abnormal_defecation | 1.04784380 |
| 68 | MP0000427_abnormal_hair_cycle | 1.04562982 |
| 69 | MP0003183_abnormal_peptide_metabolism | 1.04543947 |
| 70 | MP0001533_abnormal_skeleton_physiology | 1.02620774 |
| 71 | MP0000604_amyloidosis | 1.01824250 |
| 72 | MP0000858_altered_metastatic_potential | 1.01607202 |
| 73 | MP0009278_abnormal_bone_marrow | 1.01259503 |
| 74 | MP0002277_abnormal_respiratory_mucosa | 1.00374376 |
| 75 | MP0005376_homeostasis/metabolism_phenot | 0.99725324 |
| 76 | MP0003632_abnormal_nervous_system | 0.93996114 |
| 77 | MP0003329_amyloid_beta_deposits | 0.92355252 |
| 78 | MP0002148_abnormal_hypersensitivity_rea | 0.90877688 |
| 79 | MP0003091_abnormal_cell_migration | 0.87489635 |
| 80 | MP0001958_emphysema | 0.87370271 |
| 81 | MP0006054_spinal_hemorrhage | 0.80715633 |
| 82 | MP0000371_diluted_coat_color | 0.77910579 |
| 83 | MP0000249_abnormal_blood_vessel | 0.75220747 |
| 84 | MP0005266_abnormal_metabolism | 0.73430759 |
| 85 | MP0002998_abnormal_bone_remodeling | 0.71947023 |
| 86 | MP0008874_decreased_physiological_sensi | 0.67880322 |
| 87 | MP0008469_abnormal_protein_level | 0.66213585 |
| 88 | MP0003448_altered_tumor_morphology | 0.65531809 |
| 89 | MP0002928_abnormal_bile_duct | 0.65363789 |
| 90 | MP0003191_abnormal_cellular_cholesterol | 0.62083027 |
| 91 | MP0010155_abnormal_intestine_physiology | 0.61265928 |
| 92 | MP0002133_abnormal_respiratory_system | 0.59487905 |
| 93 | MP0005388_respiratory_system_phenotype | 0.59487905 |
| 94 | MP0001440_abnormal_grooming_behavior | 0.57503480 |
| 95 | MP0009765_abnormal_xenobiotic_induced | 0.57429689 |
| 96 | MP0002019_abnormal_tumor_incidence | 0.55664276 |
| 97 | MP0003075_altered_response_to | 0.54558681 |
| 98 | MP0005409_darkened_coat_color | 0.54335013 |
| 99 | MP0002095_abnormal_skin_pigmentation | 0.51155691 |
| 100 | MP0005621_abnormal_cell_physiology | 0.50031115 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 7.14917250 |
| 2 | Recurrent bacterial skin infections (HP:0005406) | 6.16279270 |
| 3 | T lymphocytopenia (HP:0005403) | 5.69944808 |
| 4 | Abnormality of T cell number (HP:0011839) | 5.34563197 |
| 5 | Recurrent abscess formation (HP:0002722) | 5.16397547 |
| 6 | Optic neuritis (HP:0100653) | 5.08199308 |
| 7 | Retrobulbar optic neuritis (HP:0100654) | 5.08199308 |
| 8 | Orchitis (HP:0100796) | 4.69616740 |
| 9 | Gastrointestinal infarctions (HP:0005244) | 4.56746003 |
| 10 | Myositis (HP:0100614) | 4.42969563 |
| 11 | Eczematoid dermatitis (HP:0000976) | 4.31123506 |
| 12 | Peritonitis (HP:0002586) | 4.10367525 |
| 13 | Subacute progressive viral hepatitis (HP:0006572) | 4.08157085 |
| 14 | Abnormality of macrophages (HP:0004311) | 3.92218015 |
| 15 | Gingival bleeding (HP:0000225) | 3.90653175 |
| 16 | Keratoconjunctivitis sicca (HP:0001097) | 3.85710377 |
| 17 | Recurrent fungal infections (HP:0002841) | 3.80992882 |
| 18 | Gingivitis (HP:0000230) | 3.72817924 |
| 19 | Arterial thrombosis (HP:0004420) | 3.69458197 |
| 20 | Postural instability (HP:0002172) | 3.69359167 |
| 21 | Recurrent skin infections (HP:0001581) | 3.67645718 |
| 22 | Keratoconjunctivitis (HP:0001096) | 3.54728856 |
| 23 | Papillary thyroid carcinoma (HP:0002895) | 3.48403097 |
| 24 | Resting tremor (HP:0002322) | 3.46626292 |
| 25 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.40412254 |
| 26 | Stomatitis (HP:0010280) | 3.30121218 |
| 27 | Abnormality of T cells (HP:0002843) | 3.22467382 |
| 28 | Pelvic girdle muscle weakness (HP:0003749) | 3.15013216 |
| 29 | Spontaneous hematomas (HP:0007420) | 3.14411735 |
| 30 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.08925678 |
| 31 | Visual hallucinations (HP:0002367) | 2.98760332 |
| 32 | Recurrent cutaneous fungal infections (HP:0011370) | 2.96532627 |
| 33 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.96532627 |
| 34 | Encephalitis (HP:0002383) | 2.95802910 |
| 35 | Viral hepatitis (HP:0006562) | 2.92569663 |
| 36 | Chest pain (HP:0100749) | 2.78991588 |
| 37 | Leukocytosis (HP:0001974) | 2.77406968 |
| 38 | Abnormality of the hip-girdle musculature (HP:0001445) | 2.69568921 |
| 39 | Abnormality of the musculature of the pelvis (HP:0001469) | 2.69568921 |
| 40 | Slow saccadic eye movements (HP:0000514) | 2.67154583 |
| 41 | Conjunctival telangiectasia (HP:0000524) | 2.65997142 |
| 42 | Genetic anticipation (HP:0003743) | 2.64845293 |
| 43 | Periodontitis (HP:0000704) | 2.64200473 |
| 44 | Thyroiditis (HP:0100646) | 2.64178685 |
| 45 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.64085945 |
| 46 | Mediastinal lymphadenopathy (HP:0100721) | 2.63788654 |
| 47 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.63454475 |
| 48 | Anorexia (HP:0002039) | 2.60809655 |
| 49 | Hemoptysis (HP:0002105) | 2.59194064 |
| 50 | Recurrent viral infections (HP:0004429) | 2.52206994 |
| 51 | Meningitis (HP:0001287) | 2.49998240 |
| 52 | Vasculitis (HP:0002633) | 2.47646405 |
| 53 | Urticaria (HP:0001025) | 2.46665772 |
| 54 | Epistaxis (HP:0000421) | 2.42727085 |
| 55 | Pulmonary embolism (HP:0002204) | 2.42364167 |
| 56 | Eosinophilia (HP:0001880) | 2.42215332 |
| 57 | Recurrent bronchitis (HP:0002837) | 2.41360220 |
| 58 | Thyroid carcinoma (HP:0002890) | 2.39491734 |
| 59 | Gangrene (HP:0100758) | 2.39356406 |
| 60 | Abnormality of the peritoneum (HP:0002585) | 2.35657339 |
| 61 | Acute hepatic failure (HP:0006554) | 2.32334787 |
| 62 | Abnormality of the common coagulation pathway (HP:0010990) | 2.24969721 |
| 63 | Abnormality of eosinophils (HP:0001879) | 2.22480434 |
| 64 | Stomach cancer (HP:0012126) | 2.22153995 |
| 65 | Hypoplasia of the thymus (HP:0000778) | 2.21558653 |
| 66 | Hepatitis (HP:0012115) | 2.19353527 |
| 67 | IgA deficiency (HP:0002720) | 2.17307585 |
| 68 | Obstructive lung disease (HP:0006536) | 2.14681253 |
| 69 | Chronic obstructive pulmonary disease (HP:0006510) | 2.14681253 |
| 70 | Neoplasm of the tracheobronchial system (HP:0100552) | 2.09860840 |
| 71 | Cellular immunodeficiency (HP:0005374) | 2.09653528 |
| 72 | Micronodular cirrhosis (HP:0001413) | 2.08781902 |
| 73 | Abnormality of the endocardium (HP:0004306) | 2.07723870 |
| 74 | Neurodegeneration (HP:0002180) | 2.06636828 |
| 75 | IgM deficiency (HP:0002850) | 2.05805851 |
| 76 | Episodic fever (HP:0001954) | 2.05138770 |
| 77 | Pulmonary infiltrates (HP:0002113) | 2.04481614 |
| 78 | Orthostatic hypotension (HP:0001278) | 2.01372653 |
| 79 | Inflammation of the large intestine (HP:0002037) | 1.97149035 |
| 80 | Cellulitis (HP:0100658) | 1.95585572 |
| 81 | Increased serum ferritin (HP:0003281) | 1.95105628 |
| 82 | Granulocytopenia (HP:0001913) | 1.93433310 |
| 83 | Hemiplegia (HP:0002301) | 1.93216724 |
| 84 | Poikilocytosis (HP:0004447) | 1.92003906 |
| 85 | Autoimmune hemolytic anemia (HP:0001890) | 1.89849524 |
| 86 | Prolonged bleeding time (HP:0003010) | 1.89162019 |
| 87 | Colitis (HP:0002583) | 1.88807979 |
| 88 | Foot dorsiflexor weakness (HP:0009027) | 1.87990965 |
| 89 | Aplasia/Hypoplasia of the macula (HP:0008059) | 1.87400985 |
| 90 | Mask-like facies (HP:0000298) | 1.84318587 |
| 91 | Facial diplegia (HP:0001349) | 1.83816194 |
| 92 | Tinnitus (HP:0000360) | 1.82297037 |
| 93 | Keratitis (HP:0000491) | 1.80282827 |
| 94 | Verrucae (HP:0200043) | 1.79595367 |
| 95 | Papilloma (HP:0012740) | 1.79595367 |
| 96 | Myocardial infarction (HP:0001658) | 1.79195220 |
| 97 | Vertigo (HP:0002321) | 1.77250627 |
| 98 | Acute myeloid leukemia (HP:0004808) | 1.75783165 |
| 99 | Thrombophlebitis (HP:0004418) | 1.73869148 |
| 100 | Abnormality of the fingertips (HP:0001211) | 1.72785423 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FRK | 3.81871864 |
| 2 | RIPK4 | 3.47411684 |
| 3 | BLK | 3.38049573 |
| 4 | GRK6 | 2.72175344 |
| 5 | IRAK4 | 2.67979015 |
| 6 | FGR | 2.65335189 |
| 7 | MAP3K2 | 2.62196232 |
| 8 | IRAK1 | 2.47259956 |
| 9 | IRAK2 | 2.37456462 |
| 10 | TAOK3 | 2.34432976 |
| 11 | CSK | 2.27828380 |
| 12 | IKBKE | 2.26876931 |
| 13 | WNK1 | 2.14270994 |
| 14 | TXK | 2.12052282 |
| 15 | YES1 | 1.93908231 |
| 16 | PTK2B | 1.90857327 |
| 17 | MAP2K3 | 1.82891876 |
| 18 | PIK3CG | 1.82377298 |
| 19 | JAK3 | 1.80667503 |
| 20 | SYK | 1.77101771 |
| 21 | FGFR3 | 1.77048394 |
| 22 | FES | 1.74874625 |
| 23 | GRK5 | 1.68920515 |
| 24 | BMPR2 | 1.65653695 |
| 25 | STK4 | 1.62790810 |
| 26 | PLK2 | 1.51298997 |
| 27 | SGK2 | 1.50029506 |
| 28 | PAK3 | 1.43847804 |
| 29 | BTK | 1.40966293 |
| 30 | TYK2 | 1.35404874 |
| 31 | MAP4K1 | 1.32386098 |
| 32 | ERBB2 | 1.31259266 |
| 33 | MAP3K14 | 1.29112804 |
| 34 | LRRK2 | 1.26858679 |
| 35 | JAK1 | 1.21286242 |
| 36 | ACVR1B | 1.20121760 |
| 37 | TEC | 1.18649522 |
| 38 | HCK | 1.17820837 |
| 39 | JAK2 | 1.17774970 |
| 40 | KSR2 | 1.16896185 |
| 41 | CAMKK2 | 1.13256836 |
| 42 | LYN | 1.12369187 |
| 43 | MAP3K1 | 1.10915152 |
| 44 | PIM1 | 1.08770414 |
| 45 | KSR1 | 1.08760625 |
| 46 | STK11 | 1.06973251 |
| 47 | ITK | 1.04529979 |
| 48 | RAF1 | 1.04494328 |
| 49 | ZAP70 | 1.03744682 |
| 50 | SGK3 | 1.03219885 |
| 51 | DYRK1A | 1.02870910 |
| 52 | MAP3K6 | 0.94982952 |
| 53 | NEK6 | 0.94128851 |
| 54 | MARK2 | 0.92434418 |
| 55 | NLK | 0.92036603 |
| 56 | EPHB1 | 0.90121808 |
| 57 | SGK223 | 0.86949514 |
| 58 | SGK494 | 0.86949514 |
| 59 | LCK | 0.86653760 |
| 60 | MARK3 | 0.84929156 |
| 61 | MATK | 0.84297945 |
| 62 | TGFBR2 | 0.75160114 |
| 63 | SGK1 | 0.68926204 |
| 64 | DYRK1B | 0.66322069 |
| 65 | TRPM7 | 0.65605277 |
| 66 | RPS6KB2 | 0.65084948 |
| 67 | MAP3K5 | 0.63954444 |
| 68 | FGFR2 | 0.61490126 |
| 69 | DMPK | 0.61354397 |
| 70 | MAP2K4 | 0.60804343 |
| 71 | ADRBK1 | 0.60411420 |
| 72 | EGFR | 0.60308597 |
| 73 | DYRK3 | 0.57582766 |
| 74 | TAOK1 | 0.56215817 |
| 75 | PDK1 | 0.56214758 |
| 76 | IKBKB | 0.55356092 |
| 77 | STK38 | 0.55293986 |
| 78 | CAMK4 | 0.54091874 |
| 79 | CDK12 | 0.53463894 |
| 80 | MAP3K3 | 0.51733289 |
| 81 | KIT | 0.51287410 |
| 82 | AKT3 | 0.50071547 |
| 83 | PDGFRB | 0.49378184 |
| 84 | MAP3K13 | 0.47486766 |
| 85 | CSF1R | 0.46202472 |
| 86 | CLK1 | 0.44530160 |
| 87 | NUAK1 | 0.43955059 |
| 88 | MAP2K6 | 0.42409894 |
| 89 | MAP3K11 | 0.42294939 |
| 90 | WNK3 | 0.41701543 |
| 91 | TBK1 | 0.41554586 |
| 92 | CHUK | 0.41204154 |
| 93 | CAMK1D | 0.39739623 |
| 94 | RET | 0.38550180 |
| 95 | MELK | 0.38099197 |
| 96 | CAMKK1 | 0.36893811 |
| 97 | FYN | 0.35224203 |
| 98 | NTRK3 | 0.33395761 |
| 99 | HIPK2 | 0.33249210 |
| 100 | STK10 | 0.32912284 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Leishmaniasis_Homo sapiens_hsa05140 | 2.85288326 |
| 2 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.53233765 |
| 3 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.36630742 |
| 4 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.35695350 |
| 5 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.31762981 |
| 6 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.27446228 |
| 7 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 2.13728645 |
| 8 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 2.12383868 |
| 9 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 2.07633923 |
| 10 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.03241143 |
| 11 | Tuberculosis_Homo sapiens_hsa05152 | 1.93402258 |
| 12 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.89844442 |
| 13 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.75335589 |
| 14 | Measles_Homo sapiens_hsa05162 | 1.71124459 |
| 15 | Legionellosis_Homo sapiens_hsa05134 | 1.70317167 |
| 16 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.65949562 |
| 17 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.64186930 |
| 18 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.62522143 |
| 19 | Malaria_Homo sapiens_hsa05144 | 1.56872615 |
| 20 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.49647859 |
| 21 | FoxO signaling pathway_Homo sapiens_hsa04068 | 1.49022400 |
| 22 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.45595551 |
| 23 | Hepatitis B_Homo sapiens_hsa05161 | 1.43330689 |
| 24 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.40752693 |
| 25 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.40290135 |
| 26 | Platelet activation_Homo sapiens_hsa04611 | 1.39098121 |
| 27 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.36647178 |
| 28 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.36412123 |
| 29 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.35489396 |
| 30 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.35096095 |
| 31 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.31964984 |
| 32 | Apoptosis_Homo sapiens_hsa04210 | 1.30550569 |
| 33 | Influenza A_Homo sapiens_hsa05164 | 1.26759871 |
| 34 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.26662586 |
| 35 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.25780960 |
| 36 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.22654257 |
| 37 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.22161075 |
| 38 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.18269925 |
| 39 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.18180354 |
| 40 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.13468839 |
| 41 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 1.11589467 |
| 42 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.11476934 |
| 43 | Endometrial cancer_Homo sapiens_hsa05213 | 1.09436194 |
| 44 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.07244508 |
| 45 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.07116317 |
| 46 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.05149376 |
| 47 | Hepatitis C_Homo sapiens_hsa05160 | 1.03415980 |
| 48 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.00590381 |
| 49 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.00571084 |
| 50 | Glioma_Homo sapiens_hsa05214 | 0.97129023 |
| 51 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.89426069 |
| 52 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.89176522 |
| 53 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.85560161 |
| 54 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.84600009 |
| 55 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.80176958 |
| 56 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.78688788 |
| 57 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.76896655 |
| 58 | Prostate cancer_Homo sapiens_hsa05215 | 0.75591431 |
| 59 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.74143554 |
| 60 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.73023249 |
| 61 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.72598952 |
| 62 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.72338210 |
| 63 | Phagosome_Homo sapiens_hsa04145 | 0.70724780 |
| 64 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.70008778 |
| 65 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.69615041 |
| 66 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.69344668 |
| 67 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.67753367 |
| 68 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.66750887 |
| 69 | Allograft rejection_Homo sapiens_hsa05330 | 0.65620093 |
| 70 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.65065419 |
| 71 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.64620435 |
| 72 | Long-term potentiation_Homo sapiens_hsa04720 | 0.64068567 |
| 73 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.64052856 |
| 74 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.62647189 |
| 75 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.62352563 |
| 76 | Insulin resistance_Homo sapiens_hsa04931 | 0.61278596 |
| 77 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.59816058 |
| 78 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.58783304 |
| 79 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.57932622 |
| 80 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.56839275 |
| 81 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.55484212 |
| 82 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.54352530 |
| 83 | Amoebiasis_Homo sapiens_hsa05146 | 0.53270032 |
| 84 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.52545474 |
| 85 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.52440310 |
| 86 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.52298752 |
| 87 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.52191639 |
| 88 | Pertussis_Homo sapiens_hsa05133 | 0.52145133 |
| 89 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.51691692 |
| 90 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.50511918 |
| 91 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.50475462 |
| 92 | Long-term depression_Homo sapiens_hsa04730 | 0.49204735 |
| 93 | Salmonella infection_Homo sapiens_hsa05132 | 0.48331237 |
| 94 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.46786802 |
| 95 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.46411266 |
| 96 | Thyroid cancer_Homo sapiens_hsa05216 | 0.43372585 |
| 97 | Colorectal cancer_Homo sapiens_hsa05210 | 0.43359348 |
| 98 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.42438925 |
| 99 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.41695846 |
| 100 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.41439566 |

