ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	histone H3-K36 demethylation (GO:0070544)	6.27221466
2	establishment of protein localization to Golgi (GO:0072600)	5.87973873
3	protein targeting to Golgi (GO:0000042)	5.34515452
4	detection of light stimulus involved in sensory perception (GO:0050962)	5.28699246
5	detection of light stimulus involved in visual perception (GO:0050908)	5.28699246
6	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.21889368
7	regulation of meiosis I (GO:0060631)	5.14686484
8	fucose catabolic process (GO:0019317)	4.93148372
9	L-fucose metabolic process (GO:0042354)	4.93148372
10	L-fucose catabolic process (GO:0042355)	4.93148372
11	cullin deneddylation (GO:0010388)	4.69466987
12	protein localization to Golgi apparatus (GO:0034067)	4.45224875
13	response to pheromone (GO:0019236)	4.17371545
14	protein deneddylation (GO:0000338)	4.15500171
15	GTP biosynthetic process (GO:0006183)	4.06524037
16	water-soluble vitamin biosynthetic process (GO:0042364)	4.03876488
17	maturation of 5.8S rRNA (GO:0000460)	3.94302598
18	regulation of protein kinase A signaling (GO:0010738)	3.86686206
19	vitamin transmembrane transport (GO:0035461)	3.70428066
20	atrial cardiac muscle cell action potential (GO:0086014)	3.58219434
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.51763425
22	NADH dehydrogenase complex assembly (GO:0010257)	3.51763425
23	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.51763425
24	cyclic nucleotide catabolic process (GO:0009214)	3.50364552
25	proline transport (GO:0015824)	3.47343443
26	anterograde synaptic vesicle transport (GO:0048490)	3.45671803
27	negative regulation of cardiac muscle tissue growth (GO:0055022)	3.42886590
28	negative regulation of heart growth (GO:0061117)	3.42886590
29	cAMP catabolic process (GO:0006198)	3.42136617
30	short-chain fatty acid metabolic process (GO:0046459)	3.39089998
31	meiotic chromosome segregation (GO:0045132)	3.38399310
32	replication fork processing (GO:0031297)	3.35583385
33	negative regulation of DNA recombination (GO:0045910)	3.32269000
34	UTP biosynthetic process (GO:0006228)	3.31599994
35	protein K11-linked deubiquitination (GO:0035871)	3.31010834
36	mRNA cleavage (GO:0006379)	3.30163265
37	adult heart development (GO:0007512)	3.28979521
38	UTP metabolic process (GO:0046051)	3.26173052
39	preassembly of GPI anchor in ER membrane (GO:0016254)	3.10828108
40	histone mRNA metabolic process (GO:0008334)	3.06362545
41	kinetochore organization (GO:0051383)	3.00764255
42	cGMP metabolic process (GO:0046068)	3.00328654
43	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.99230484
44	indolalkylamine metabolic process (GO:0006586)	2.98222896
45	multicellular organism reproduction (GO:0032504)	2.89875983
46	negative regulation of neurotransmitter transport (GO:0051589)	2.89235640
47	calcium ion import (GO:0070509)	2.88951227
48	regulation of DNA endoreduplication (GO:0032875)	2.83807763
49	positive regulation of developmental pigmentation (GO:0048087)	2.83759481
50	regulation of mesoderm development (GO:2000380)	2.83054563
51	nucleoside diphosphate phosphorylation (GO:0006165)	2.83022990
52	neurotransmitter uptake (GO:0001504)	2.82696062
53	ubiquinone metabolic process (GO:0006743)	2.80821469
54	tryptophan catabolic process (GO:0006569)	2.79367986
55	indole-containing compound catabolic process (GO:0042436)	2.79367986
56	indolalkylamine catabolic process (GO:0046218)	2.79367986
57	dopamine transport (GO:0015872)	2.77821472
58	protein complex biogenesis (GO:0070271)	2.75132376
59	adult feeding behavior (GO:0008343)	2.74922528
60	mismatch repair (GO:0006298)	2.74198286
61	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.72905153
62	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.72797162
63	GPI anchor metabolic process (GO:0006505)	2.72562942
64	DNA double-strand break processing (GO:0000729)	2.72362340
65	C4-dicarboxylate transport (GO:0015740)	2.71658747
66	double-strand break repair via homologous recombination (GO:0000724)	2.71383921
67	recombinational repair (GO:0000725)	2.71086161
68	microtubule anchoring (GO:0034453)	2.70210051
69	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.69267647
70	intra-Golgi vesicle-mediated transport (GO:0006891)	2.68180597
71	ubiquinone biosynthetic process (GO:0006744)	2.66627049
72	nonmotile primary cilium assembly (GO:0035058)	2.66213007
73	histone mRNA catabolic process (GO:0071044)	2.65223055
74	kinetochore assembly (GO:0051382)	2.64459724
75	glycine transport (GO:0015816)	2.64056957
76	DNA catabolic process, exonucleolytic (GO:0000738)	2.63611651
77	reflex (GO:0060004)	2.63482155
78	CTP metabolic process (GO:0046036)	2.62989087
79	CTP biosynthetic process (GO:0006241)	2.62989087
80	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.62232797
81	tryptophan metabolic process (GO:0006568)	2.62076193
82	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.61929837
83	rRNA catabolic process (GO:0016075)	2.61087252
84	reciprocal DNA recombination (GO:0035825)	2.60684910
85	reciprocal meiotic recombination (GO:0007131)	2.60684910
86	protein K6-linked ubiquitination (GO:0085020)	2.58635342
87	regulation of pigment cell differentiation (GO:0050932)	2.55918596
88	regulation of establishment of cell polarity (GO:2000114)	2.54702245
89	biotin metabolic process (GO:0006768)	2.52827783
90	respiratory chain complex IV assembly (GO:0008535)	2.52629548
91	sphingoid metabolic process (GO:0046519)	2.52257512
92	protein K63-linked deubiquitination (GO:0070536)	2.51625912
93	endosome to melanosome transport (GO:0035646)	2.51248815
94	endosome to pigment granule transport (GO:0043485)	2.51248815
95	mitochondrial respiratory chain complex assembly (GO:0033108)	2.50339063
96	sphingosine metabolic process (GO:0006670)	2.49783498
97	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.49741097
98	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.46317274
99	skeletal muscle tissue regeneration (GO:0043403)	2.45812168
100	guanosine-containing compound biosynthetic process (GO:1901070)	2.44889298

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.58480961
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.59486720
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.20490460
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.16077279
5	FUS_26573619_Chip-Seq_HEK293_Human	2.86912408
6	EWS_26573619_Chip-Seq_HEK293_Human	2.85544419
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.79324677
8	VDR_22108803_ChIP-Seq_LS180_Human	2.55233124
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.44591484
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.39350301
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.31641088
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.28082254
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.27448187
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.15943069
15	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.14363176
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.09695325
17	P300_19829295_ChIP-Seq_ESCs_Human	2.04817968
18	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.98364661
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.88038154
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.85669437
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82819518
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.77111350
23	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.76358547
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.74580248
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.73623499
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.70415907
27	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.65034848
28	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.56116444
29	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.54985856
30	STAT3_23295773_ChIP-Seq_U87_Human	1.51360168
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.51328851
32	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.48894689
33	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.43342829
34	AR_21572438_ChIP-Seq_LNCaP_Human	1.40833259
35	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.40430651
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.37517694
37	TCF4_22108803_ChIP-Seq_LS180_Human	1.37041063
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.36796231
39	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.36408513
40	VDR_23849224_ChIP-Seq_CD4+_Human	1.36378564
41	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35964744
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.35891826
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.35891826
44	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.35888149
45	TCF4_23295773_ChIP-Seq_U87_Human	1.35154124
46	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.34519513
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.33860696
48	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.33574725
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33301820
50	BCAT_22108803_ChIP-Seq_LS180_Human	1.30787346
51	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.30772464
52	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27711905
53	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.27706399
54	P53_22387025_ChIP-Seq_ESCs_Mouse	1.26763994
55	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.25656623
56	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25586924
57	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.24549809
58	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.23807074
59	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.22774550
60	CDX2_22108803_ChIP-Seq_LS180_Human	1.21684030
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21079991
62	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20334185
63	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.19932007
64	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18723731
65	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.18229692
66	TP53_16413492_ChIP-PET_HCT116_Human	1.14480611
67	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.14356915
68	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.13792225
69	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12906131
70	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.12049555
71	AR_25329375_ChIP-Seq_VCAP_Human	1.11892202
72	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.11389712
73	ETV1_20927104_ChIP-Seq_GIST48_Human	1.10569581
74	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08736203
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07822768
76	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07691211
77	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.06962449
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06573365
79	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06573365
80	NFYB_21822215_ChIP-Seq_K562_Human	1.06472961
81	TBL1_22424771_ChIP-Seq_293T_Human	1.06401419
82	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.06393493
83	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06299545
84	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.05905767
85	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05818351
86	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.04115969
87	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.03287439
88	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.02931106
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02440675
90	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.02433061
91	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01838819
92	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.01071289
93	FOXP3_21729870_ChIP-Seq_TREG_Human	0.99463672
94	JUN_21703547_ChIP-Seq_K562_Human	0.99459922
95	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.99352509
96	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.99081012
97	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.98811454
98	P300_18555785_Chip-Seq_ESCs_Mouse	0.98272092
99	PHF8_20622853_ChIP-Seq_HELA_Human	0.98060568
100	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.97997777

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	3.95374933
2	MP0002837_dystrophic_cardiac_calcinosis	3.28269531
3	MP0008007_abnormal_cellular_replicative	3.03285845
4	MP0004043_abnormal_pH_regulation	3.00384366
5	MP0003786_premature_aging	2.81008391
6	MP0008058_abnormal_DNA_repair	2.78312810
7	MP0000383_abnormal_hair_follicle	2.72006850
8	MP0010094_abnormal_chromosome_stability	2.66238365
9	MP0004147_increased_porphyrin_level	2.64203713
10	MP0009384_cardiac_valve_regurgitation	2.57599688
11	MP0008057_abnormal_DNA_replication	2.46864816
12	MP0010352_gastrointestinal_tract_polyps	2.44999602
13	MP0004215_abnormal_myocardial_fiber	2.20184845
14	MP0005171_absent_coat_pigmentation	2.15162611
15	MP0004484_altered_response_of	2.13103513
16	MP0009697_abnormal_copulation	2.10319902
17	MP0002102_abnormal_ear_morphology	1.95576473
18	MP0003890_abnormal_embryonic-extraembry	1.85356763
19	MP0000427_abnormal_hair_cycle	1.79864771
20	MP0000569_abnormal_digit_pigmentation	1.78254706
21	MP0003950_abnormal_plasma_membrane	1.78002876
22	MP0004142_abnormal_muscle_tone	1.77240530
23	MP0003880_abnormal_central_pattern	1.72126273
24	MP0005551_abnormal_eye_electrophysiolog	1.71532857
25	MP0003690_abnormal_glial_cell	1.70222857
26	MP0010678_abnormal_skin_adnexa	1.65372649
27	MP0005395_other_phenotype	1.58821582
28	MP0009046_muscle_twitch	1.54505920
29	MP0005645_abnormal_hypothalamus_physiol	1.50794626
30	MP0006292_abnormal_olfactory_placode	1.50346992
31	MP0008995_early_reproductive_senescence	1.49972970
32	MP0008775_abnormal_heart_ventricle	1.49402902
33	MP0000579_abnormal_nail_morphology	1.44244327
34	MP0003195_calcinosis	1.43433731
35	MP0005646_abnormal_pituitary_gland	1.42999045
36	MP0005187_abnormal_penis_morphology	1.42803516
37	MP0001984_abnormal_olfaction	1.36407960
38	MP0001501_abnormal_sleep_pattern	1.35678659
39	MP0000566_synostosis	1.32179053
40	MP0001299_abnormal_eye_distance/	1.27294882
41	MP0000015_abnormal_ear_pigmentation	1.23441351
42	MP0006035_abnormal_mitochondrial_morpho	1.18774427
43	MP0002938_white_spotting	1.17073063
44	MP0000372_irregular_coat_pigmentation	1.16672768
45	MP0002009_preneoplasia	1.16641556
46	MP0005174_abnormal_tail_pigmentation	1.14235468
47	MP0009745_abnormal_behavioral_response	1.12731659
48	MP0008872_abnormal_physiological_respon	1.12231410
49	MP0003937_abnormal_limbs/digits/tail_de	1.06265158
50	MP0002396_abnormal_hematopoietic_system	1.05744093
51	MP0002177_abnormal_outer_ear	1.02620797
52	MP0008961_abnormal_basal_metabolism	1.02517907
53	MP0004084_abnormal_cardiac_muscle	1.02002127
54	MP0002876_abnormal_thyroid_physiology	0.99553802
55	MP0008877_abnormal_DNA_methylation	0.99532815
56	MP0002693_abnormal_pancreas_physiology	0.99124393
57	MP0001853_heart_inflammation	0.98337747
58	MP0006036_abnormal_mitochondrial_physio	0.96436639
59	MP0002733_abnormal_thermal_nociception	0.96049370
60	MP0005408_hypopigmentation	0.94875673
61	MP0002638_abnormal_pupillary_reflex	0.94396748
62	MP0002234_abnormal_pharynx_morphology	0.94382858
63	MP0005167_abnormal_blood-brain_barrier	0.94224234
64	MP0008789_abnormal_olfactory_epithelium	0.93199932
65	MP0003111_abnormal_nucleus_morphology	0.89611831
66	MP0008875_abnormal_xenobiotic_pharmacok	0.88995935
67	MP0000358_abnormal_cell_content/	0.85931503
68	MP0002184_abnormal_innervation	0.84785738
69	MP0002095_abnormal_skin_pigmentation	0.83634912
70	MP0003011_delayed_dark_adaptation	0.83342578
71	MP0002557_abnormal_social/conspecific_i	0.83172434
72	MP0005253_abnormal_eye_physiology	0.82177488
73	MP0000230_abnormal_systemic_arterial	0.81006607
74	MP0001968_abnormal_touch/_nociception	0.80984686
75	MP0003077_abnormal_cell_cycle	0.80933450
76	MP0003632_abnormal_nervous_system	0.80847714
77	MP0000639_abnormal_adrenal_gland	0.80035307
78	MP0004085_abnormal_heartbeat	0.79299430
79	MP0005499_abnormal_olfactory_system	0.78880494
80	MP0005394_taste/olfaction_phenotype	0.78880494
81	MP0005410_abnormal_fertilization	0.78178712
82	MP0000428_abnormal_craniofacial_morphol	0.76970608
83	MP0002269_muscular_atrophy	0.74474381
84	MP0008873_increased_physiological_sensi	0.73804603
85	MP0000631_abnormal_neuroendocrine_gland	0.73595397
86	MP0003186_abnormal_redox_activity	0.72359549
87	MP0002233_abnormal_nose_morphology	0.72072021
88	MP0001324_abnormal_eye_pigmentation	0.71189444
89	MP0003633_abnormal_nervous_system	0.69270419
90	MP0001970_abnormal_pain_threshold	0.67981328
91	MP0003631_nervous_system_phenotype	0.67486673
92	MP0003698_abnormal_male_reproductive	0.65468508
93	MP0001191_abnormal_skin_condition	0.64027613
94	MP0002736_abnormal_nociception_after	0.63933157
95	MP0004957_abnormal_blastocyst_morpholog	0.63223317
96	MP0002109_abnormal_limb_morphology	0.61502099
97	MP0002064_seizures	0.60709252
98	MP0002909_abnormal_adrenal_gland	0.60022475
99	MP0006276_abnormal_autonomic_nervous	0.58972966
100	MP0003137_abnormal_impulse_conducting	0.57475964

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	6.62947021
2	Central scotoma (HP:0000603)	5.71521025
3	Tetraparesis (HP:0002273)	5.44873877
4	Aplasia/Hypoplasia of the fovea (HP:0008060)	5.31650255
5	Hypoplasia of the fovea (HP:0007750)	5.31650255
6	Severe visual impairment (HP:0001141)	5.11720028
7	Abnormality of the fovea (HP:0000493)	4.45389122
8	Retrobulbar optic neuritis (HP:0100654)	4.30795929
9	Optic neuritis (HP:0100653)	4.30795929
10	Albinism (HP:0001022)	4.11628620
11	Abnormality of macular pigmentation (HP:0008002)	3.93628462
12	Abnormal rod and cone electroretinograms (HP:0008323)	3.77537890
13	Orchitis (HP:0100796)	3.48105533
14	Median cleft lip (HP:0000161)	3.23483365
15	Scotoma (HP:0000575)	3.22544734
16	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.20338462
17	Aplasia/Hypoplasia of the macula (HP:0008059)	3.17542820
18	Colon cancer (HP:0003003)	2.97306929
19	Keratoconjunctivitis sicca (HP:0001097)	2.93968006
20	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.92121800
21	Keratoconjunctivitis (HP:0001096)	2.75316836
22	Tubulointerstitial nephritis (HP:0001970)	2.68284564
23	Short middle phalanx of the 5th finger (HP:0004220)	2.65793388
24	Abnormality of the renal cortex (HP:0011035)	2.65048928
25	Dry hair (HP:0011359)	2.64624236
26	Febrile seizures (HP:0002373)	2.64146275
27	Tubulointerstitial abnormality (HP:0001969)	2.58621864
28	Generalized aminoaciduria (HP:0002909)	2.58170253
29	Renal cortical cysts (HP:0000803)	2.48405110
30	Short tibia (HP:0005736)	2.45561141
31	Aplasia involving bones of the upper limbs (HP:0009823)	2.44365321
32	Aplasia of the phalanges of the hand (HP:0009802)	2.44365321
33	Aplasia involving bones of the extremities (HP:0009825)	2.44365321
34	Portal hypertension (HP:0001409)	2.43609443
35	Myositis (HP:0100614)	2.36130794
36	Progressive inability to walk (HP:0002505)	2.28983394
37	Abnormality of the hepatic vasculature (HP:0006707)	2.25234237
38	Clubbing of toes (HP:0100760)	2.20373883
39	Retinal atrophy (HP:0001105)	2.20314003
40	Tubulointerstitial fibrosis (HP:0005576)	2.16833535
41	Acanthocytosis (HP:0001927)	2.15744708
42	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.09513121
43	Thyroid-stimulating hormone excess (HP:0002925)	2.05527931
44	Generalized hypopigmentation (HP:0007513)	2.04992643
45	Pancreatic fibrosis (HP:0100732)	2.04221110
46	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.03389650
47	Acute lymphatic leukemia (HP:0006721)	2.01675005
48	Hepatic necrosis (HP:0002605)	2.01467993
49	Long nose (HP:0003189)	2.00938787
50	Abnormality of midbrain morphology (HP:0002418)	1.99577380
51	Molar tooth sign on MRI (HP:0002419)	1.99577380
52	Astigmatism (HP:0000483)	1.99215093
53	Inability to walk (HP:0002540)	1.96407473
54	Preaxial hand polydactyly (HP:0001177)	1.93273576
55	Pancreatic cysts (HP:0001737)	1.90544087
56	Biliary tract neoplasm (HP:0100574)	1.89662738
57	Gangrene (HP:0100758)	1.87538800
58	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.82620872
59	Abnormality of alanine metabolism (HP:0010916)	1.82620872
60	Hyperalaninemia (HP:0003348)	1.82620872
61	Hepatocellular necrosis (HP:0001404)	1.82482895
62	Abnormality of chromosome stability (HP:0003220)	1.82334655
63	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.81843505
64	Abnormality of secondary sexual hair (HP:0009888)	1.81461517
65	Abnormality of the axillary hair (HP:0100134)	1.81461517
66	Hypoplastic labia majora (HP:0000059)	1.80848102
67	Ketoacidosis (HP:0001993)	1.79885334
68	Selective tooth agenesis (HP:0001592)	1.76809262
69	Chromsome breakage (HP:0040012)	1.76131962
70	Ectopic kidney (HP:0000086)	1.76126704
71	Short 5th finger (HP:0009237)	1.71832161
72	Curly hair (HP:0002212)	1.70844669
73	Neoplasm of the small intestine (HP:0100833)	1.69682589
74	Limb hypertonia (HP:0002509)	1.69314463
75	Duplicated collecting system (HP:0000081)	1.66488190
76	Medial flaring of the eyebrow (HP:0010747)	1.66047810
77	Encephalitis (HP:0002383)	1.65922679
78	Meckel diverticulum (HP:0002245)	1.65582042
79	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.65152425
80	Abnormality of the columella (HP:0009929)	1.64133392
81	Hypoplastic nipples (HP:0002557)	1.63328786
82	Polyuria (HP:0000103)	1.62896992
83	Abnormality of the preputium (HP:0100587)	1.61723324
84	Abnormality of the labia majora (HP:0012881)	1.59968853
85	Small intestinal stenosis (HP:0012848)	1.59869732
86	Duodenal stenosis (HP:0100867)	1.59869732
87	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.59222134
88	Abnormal biliary tract morphology (HP:0012440)	1.58368895
89	True hermaphroditism (HP:0010459)	1.57834850
90	Congenital primary aphakia (HP:0007707)	1.57788516
91	Abnormality of the renal medulla (HP:0100957)	1.57212326
92	Bulbous nose (HP:0000414)	1.56795342
93	Constricted visual fields (HP:0001133)	1.56691408
94	Nephronophthisis (HP:0000090)	1.56465695
95	Hypothermia (HP:0002045)	1.56270835
96	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.55746902
97	Rib fusion (HP:0000902)	1.54528189
98	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	1.54255246
99	Increased CSF lactate (HP:0002490)	1.53721465
100	Attenuation of retinal blood vessels (HP:0007843)	1.53376824

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.52474791
2	MAP2K6	4.50949432
3	BRD4	3.85777273
4	STK24	2.96201233
5	MKNK2	2.66323399
6	BUB1	2.53891129
7	ZAK	2.25781432
8	MST4	2.24753862
9	MKNK1	2.19282262
10	EIF2AK3	2.10942660
11	EPHA3	2.07058380
12	AKT3	1.91021024
13	STK3	1.75668106
14	BLK	1.63092417
15	CSNK1G2	1.62754043
16	CSNK1G3	1.60650814
17	CSNK1A1L	1.59722568
18	NME1	1.57652159
19	STK39	1.52877415
20	STK38L	1.51315822
21	ADRBK2	1.49222937
22	CSNK1G1	1.38055672
23	WNK3	1.38050505
24	TAOK3	1.37290051
25	NLK	1.36272214
26	GRK1	1.34955369
27	NUAK1	1.24819257
28	OXSR1	1.24584884
29	BRSK2	1.21746545
30	CASK	1.21247158
31	MAP2K7	1.20498036
32	MAP3K4	1.19998762
33	ATR	1.19655626
34	PLK4	1.12810581
35	ACVR1B	1.06804639
36	TNIK	1.06357327
37	MAPK12	1.04479678
38	MAPK7	1.02259293
39	CDC7	0.99933338
40	WEE1	0.99878807
41	BMPR1B	0.99240476
42	CAMKK2	0.96404750
43	CSNK1D	0.95087792
44	PDK2	0.94115472
45	NEK1	0.94040589
46	MAPKAPK5	0.93154785
47	TRPM7	0.89178754
48	WNK4	0.87903985
49	TTK	0.83097370
50	TGFBR2	0.79962341
51	TEC	0.78016453
52	RPS6KB1	0.77891401
53	YES1	0.76802905
54	FGFR1	0.74342869
55	CLK1	0.74241432
56	FER	0.73787396
57	BCR	0.70630810
58	PAK3	0.69406992
59	PRKCG	0.68586734
60	EIF2AK1	0.65995649
61	MAP3K6	0.65735524
62	PRKCE	0.65487176
63	MAP3K5	0.60636870
64	ATM	0.60565220
65	TAF1	0.58004882
66	IRAK1	0.57414200
67	PNCK	0.54776658
68	NEK9	0.54397479
69	MAPKAPK3	0.53948938
70	CDK3	0.52138354
71	STK16	0.50745719
72	CAMK2A	0.50562308
73	PIK3CA	0.49903871
74	OBSCN	0.47381791
75	TGFBR1	0.46959919
76	MAP2K4	0.46718963
77	CDK12	0.44888441
78	DAPK2	0.44404264
79	TLK1	0.44235945
80	FLT3	0.44077211
81	CSNK1A1	0.41711585
82	PAK6	0.41498412
83	ERBB3	0.40972113
84	RPS6KA5	0.40834074
85	MAPK13	0.38037143
86	PKN1	0.37784398
87	CHEK2	0.35961793
88	SGK2	0.35891808
89	ADRBK1	0.35318785
90	VRK1	0.34988212
91	ITK	0.34792509
92	TIE1	0.34602797
93	BCKDK	0.31860852
94	PLK1	0.30421898
95	DAPK1	0.30251284
96	PRKG1	0.29816791
97	CSNK1E	0.29017237
98	RPS6KA4	0.28783113
99	PRKACA	0.26855666
100	PINK1	0.26462291

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.69571247
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.23203402
3	Homologous recombination_Homo sapiens_hsa03440	2.65431125
4	One carbon pool by folate_Homo sapiens_hsa00670	2.61348668
5	Protein export_Homo sapiens_hsa03060	2.46390917
6	Propanoate metabolism_Homo sapiens_hsa00640	2.42187195
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.39738198
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.32309139
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.29599093
10	Basal transcription factors_Homo sapiens_hsa03022	2.27013536
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.05126605
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.01532059
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.97853341
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.86575969
15	Proteasome_Homo sapiens_hsa03050	1.81416177
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.78517971
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.78346519
18	RNA polymerase_Homo sapiens_hsa03020	1.71318957
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.65156234
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.55561437
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.51735286
22	Serotonergic synapse_Homo sapiens_hsa04726	1.43073039
23	Taste transduction_Homo sapiens_hsa04742	1.42248962
24	RNA degradation_Homo sapiens_hsa03018	1.39123028
25	Purine metabolism_Homo sapiens_hsa00230	1.34318227
26	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.33324509
27	Mismatch repair_Homo sapiens_hsa03430	1.32083774
28	Circadian rhythm_Homo sapiens_hsa04710	1.29511382
29	Base excision repair_Homo sapiens_hsa03410	1.28799245
30	GABAergic synapse_Homo sapiens_hsa04727	1.25348681
31	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.24102709
32	Sulfur metabolism_Homo sapiens_hsa00920	1.24077970
33	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.23554903
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.21795429
35	Morphine addiction_Homo sapiens_hsa05032	1.14655280
36	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.13553585
37	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.12051158
38	Sphingolipid metabolism_Homo sapiens_hsa00600	1.10824560
39	Oocyte meiosis_Homo sapiens_hsa04114	1.06296521
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.04006076
41	Fatty acid metabolism_Homo sapiens_hsa01212	1.03995897
42	Renin secretion_Homo sapiens_hsa04924	1.02412009
43	DNA replication_Homo sapiens_hsa03030	1.01450920
44	Pyrimidine metabolism_Homo sapiens_hsa00240	1.01439587
45	p53 signaling pathway_Homo sapiens_hsa04115	0.94611665
46	Folate biosynthesis_Homo sapiens_hsa00790	0.94413388
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92966281
48	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.92308034
49	Fatty acid elongation_Homo sapiens_hsa00062	0.90440373
50	Caffeine metabolism_Homo sapiens_hsa00232	0.89514510
51	Non-homologous end-joining_Homo sapiens_hsa03450	0.89437906
52	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.87506511
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.85692444
54	Peroxisome_Homo sapiens_hsa04146	0.84184483
55	Regulation of autophagy_Homo sapiens_hsa04140	0.83659234
56	Spliceosome_Homo sapiens_hsa03040	0.77249151
57	Phototransduction_Homo sapiens_hsa04744	0.76564377
58	Butanoate metabolism_Homo sapiens_hsa00650	0.76337602
59	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.76234505
60	Cell cycle_Homo sapiens_hsa04110	0.75335542
61	Calcium signaling pathway_Homo sapiens_hsa04020	0.72968820
62	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.71184189
63	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.67807608
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.67575977
65	Metabolic pathways_Homo sapiens_hsa01100	0.66813789
66	Insulin secretion_Homo sapiens_hsa04911	0.66392353
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.64893140
68	RNA transport_Homo sapiens_hsa03013	0.64806738
69	Glutamatergic synapse_Homo sapiens_hsa04724	0.63666066
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62953424
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62898349
72	Histidine metabolism_Homo sapiens_hsa00340	0.62125177
73	Tryptophan metabolism_Homo sapiens_hsa00380	0.60924994
74	Retinol metabolism_Homo sapiens_hsa00830	0.59835532
75	mRNA surveillance pathway_Homo sapiens_hsa03015	0.59674973
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.59633821
77	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.59072782
78	Alzheimers disease_Homo sapiens_hsa05010	0.58601104
79	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.58288692
80	Nucleotide excision repair_Homo sapiens_hsa03420	0.58221115
81	Glycerolipid metabolism_Homo sapiens_hsa00561	0.57750289
82	Oxidative phosphorylation_Homo sapiens_hsa00190	0.57725334
83	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.57406419
84	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.56821668
85	Parkinsons disease_Homo sapiens_hsa05012	0.56770466
86	Nicotine addiction_Homo sapiens_hsa05033	0.55347860
87	Mineral absorption_Homo sapiens_hsa04978	0.54663072
88	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.54079708
89	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.53061060
90	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.52190756
91	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.50427538
92	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.48980854
93	Cardiac muscle contraction_Homo sapiens_hsa04260	0.48846110
94	Olfactory transduction_Homo sapiens_hsa04740	0.48014284
95	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.44398129
96	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.43090130
97	Circadian entrainment_Homo sapiens_hsa04713	0.42970486
98	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.42493512
99	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.39981627
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.39593803

MTND5P26

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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