ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.48497760
2	negative regulation of multicellular organism growth (GO:0040015)	6.80592376
3	kynurenine metabolic process (GO:0070189)	5.89574893
4	sulfur amino acid catabolic process (GO:0000098)	5.78499415
5	mitochondrion transport along microtubule (GO:0047497)	5.63819089
6	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	5.63819089
7	cellular modified amino acid catabolic process (GO:0042219)	5.58106341
8	cytoplasmic mRNA processing body assembly (GO:0033962)	5.44458309
9	establishment of mitochondrion localization (GO:0051654)	5.04256295
10	sex differentiation (GO:0007548)	4.89741149
11	regulation of memory T cell differentiation (GO:0043380)	4.88204812
12	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	4.64635640
13	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	4.64635640
14	sequestering of actin monomers (GO:0042989)	4.63371039
15	regulation of MHC class I biosynthetic process (GO:0045343)	4.61998647
16	myelin assembly (GO:0032288)	4.61927168
17	regulation of establishment of cell polarity (GO:2000114)	4.59781834
18	somatic diversification of immune receptors via somatic mutation (GO:0002566)	4.54681564
19	somatic hypermutation of immunoglobulin genes (GO:0016446)	4.54681564
20	stress granule assembly (GO:0034063)	4.46531763
21	rRNA catabolic process (GO:0016075)	4.32920876
22	histone H3-K9 methylation (GO:0051567)	4.23370493
23	blood vessel maturation (GO:0001955)	4.21972584
24	cilium or flagellum-dependent cell motility (GO:0001539)	4.17940147
25	synaptic transmission, cholinergic (GO:0007271)	4.05789066
26	dicarboxylic acid biosynthetic process (GO:0043650)	4.05329317
27	histone H3-K9 modification (GO:0061647)	4.02362265
28	ADP metabolic process (GO:0046031)	3.92692438
29	behavioral response to nicotine (GO:0035095)	3.91787437
30	neuron cell-cell adhesion (GO:0007158)	3.81428059
31	tryptophan catabolic process (GO:0006569)	3.73655670
32	indole-containing compound catabolic process (GO:0042436)	3.73655670
33	indolalkylamine catabolic process (GO:0046218)	3.73655670
34	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.69471953
35	protein prenylation (GO:0018342)	3.67991825
36	prenylation (GO:0097354)	3.67991825
37	gamma-aminobutyric acid transport (GO:0015812)	3.64352925
38	nonmotile primary cilium assembly (GO:0035058)	3.59659969
39	postsynaptic membrane organization (GO:0001941)	3.56472444
40	DNA demethylation (GO:0080111)	3.55717215
41	neural tube formation (GO:0001841)	3.50183850
42	cerebellar Purkinje cell differentiation (GO:0021702)	3.48072474
43	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.46789036
44	regulation of action potential (GO:0098900)	3.46019839
45	cholesterol catabolic process (GO:0006707)	3.44489645
46	sterol catabolic process (GO:0016127)	3.44489645
47	negative regulation of type 2 immune response (GO:0002829)	3.43675952
48	cellular ketone body metabolic process (GO:0046950)	3.36606352
49	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.28944988
50	epithelial cilium movement (GO:0003351)	3.27493629
51	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.23857693
52	regulation of translation, ncRNA-mediated (GO:0045974)	3.23857693
53	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.23857693
54	otic vesicle formation (GO:0030916)	3.22742200
55	presynaptic membrane assembly (GO:0097105)	3.21190272
56	cAMP catabolic process (GO:0006198)	3.19277221
57	L-methionine salvage (GO:0071267)	3.13791983
58	L-methionine biosynthetic process (GO:0071265)	3.13791983
59	amino acid salvage (GO:0043102)	3.13791983
60	positive regulation of guanylate cyclase activity (GO:0031284)	3.13534829
61	alternative mRNA splicing, via spliceosome (GO:0000380)	3.09486371
62	protein K11-linked deubiquitination (GO:0035871)	3.08383936
63	aspartate family amino acid catabolic process (GO:0009068)	3.08066764
64	regulation of interleukin-13 production (GO:0032656)	3.07630553
65	peptidyl-lysine trimethylation (GO:0018023)	3.05637052
66	positive regulation of mitochondrial membrane permeability (GO:0035794)	3.01107667
67	histone H3-K4 trimethylation (GO:0080182)	3.00698616
68	behavioral response to ethanol (GO:0048149)	2.95970143
69	lipid particle organization (GO:0034389)	2.95822076
70	ketone body metabolic process (GO:1902224)	2.94561834
71	synaptic vesicle endocytosis (GO:0048488)	2.93516873
72	aspartate family amino acid biosynthetic process (GO:0009067)	2.91268583
73	L-fucose catabolic process (GO:0042355)	2.90302290
74	fucose catabolic process (GO:0019317)	2.90302290
75	L-fucose metabolic process (GO:0042354)	2.90302290
76	peristalsis (GO:0030432)	2.90253671
77	bile acid biosynthetic process (GO:0006699)	2.88847073
78	histone H3-K4 methylation (GO:0051568)	2.88755902
79	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.87182436
80	epithelial cell maturation (GO:0002070)	2.87127737
81	tryptophan metabolic process (GO:0006568)	2.86278851
82	seminiferous tubule development (GO:0072520)	2.82889883
83	protein K11-linked ubiquitination (GO:0070979)	2.81984202
84	somite rostral/caudal axis specification (GO:0032525)	2.80191562
85	regulation of guanylate cyclase activity (GO:0031282)	2.79733403
86	regulation of telomere maintenance via telomerase (GO:0032210)	2.79440041
87	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.78410862
88	hair cell differentiation (GO:0035315)	2.78303485
89	embryonic camera-type eye development (GO:0031076)	2.77932063
90	DNA dealkylation (GO:0035510)	2.77212393
91	cyclic nucleotide catabolic process (GO:0009214)	2.74870688
92	negative regulation of cAMP-mediated signaling (GO:0043951)	2.74829309
93	synapse assembly (GO:0007416)	2.73465701
94	cilium assembly (GO:0042384)	2.70610072
95	regulation of phospholipid biosynthetic process (GO:0071071)	2.67115352
96	dicarboxylic acid catabolic process (GO:0043649)	2.66203431
97	mitochondrion localization (GO:0051646)	2.64652775
98	N-acetylglucosamine metabolic process (GO:0006044)	2.63406298
99	positive regulation of neurological system process (GO:0031646)	2.62714034
100	barbed-end actin filament capping (GO:0051016)	2.61893757

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	5.25683896
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.60035517
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.97786070
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.65144451
5	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.82821297
6	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.79067408
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.70732560
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.55749266
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.36225000
10	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.12130094
11	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.05645107
12	ETV2_25802403_ChIP-Seq_MESCs_Mouse	2.00903072
13	ER_23166858_ChIP-Seq_MCF-7_Human	1.92323092
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.90977375
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.86612847
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.85862491
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.85780658
18	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.84688169
19	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.79406805
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.78438525
21	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.77290553
22	FUS_26573619_Chip-Seq_HEK293_Human	1.76676541
23	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.70943508
24	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.66943102
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.65809382
26	REST_21632747_ChIP-Seq_MESCs_Mouse	1.60433549
27	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.59981988
28	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.58970565
29	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.54568980
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.52610017
31	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.51114803
32	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.45868586
33	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.44162511
34	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.40954798
35	DROSHA_22980978_ChIP-Seq_HELA_Human	1.40175409
36	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.39601415
37	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.38930017
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.38223097
39	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.36166074
40	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.35888502
41	AR_21572438_ChIP-Seq_LNCaP_Human	1.33477349
42	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32270415
43	HTT_18923047_ChIP-ChIP_STHdh_Human	1.31498359
44	STAT3_23295773_ChIP-Seq_U87_Human	1.31208650
45	SOX9_26525672_Chip-Seq_HEART_Mouse	1.31079064
46	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28208112
47	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.28073759
48	P300_19829295_ChIP-Seq_ESCs_Human	1.26928736
49	AR_25329375_ChIP-Seq_VCAP_Human	1.26916152
50	CBP_21632823_ChIP-Seq_H3396_Human	1.26730035
51	RXR_22108803_ChIP-Seq_LS180_Human	1.26597856
52	TCF4_23295773_ChIP-Seq_U87_Human	1.26462719
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.25444147
54	SMAD4_21799915_ChIP-Seq_A2780_Human	1.25202051
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.23270111
56	IRF1_19129219_ChIP-ChIP_H3396_Human	1.23093004
57	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.22465058
58	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.21842022
59	CBP_20019798_ChIP-Seq_JUKART_Human	1.21804164
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21804164
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21679691
62	KDM2B_26808549_Chip-Seq_REH_Human	1.20927253
63	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.20834520
64	TP53_16413492_ChIP-PET_HCT116_Human	1.18909386
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.18021132
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17513527
67	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.13922845
68	IGF1R_20145208_ChIP-Seq_DFB_Human	1.12248065
69	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08818612
70	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.08752675
71	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07998023
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.06761425
73	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05390449
74	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.04551292
75	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.04162382
76	TBL1_22424771_ChIP-Seq_293T_Human	1.03581204
77	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.03161026
78	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03003584
79	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.00391704
80	OCT4_20526341_ChIP-Seq_ESCs_Human	1.00248653
81	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.99066649
82	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.98808231
83	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.98788745
84	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.98663034
85	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.97122090
86	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96891598
87	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95921864
88	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.95921864
89	ERA_21632823_ChIP-Seq_H3396_Human	0.94840833
90	EWS_26573619_Chip-Seq_HEK293_Human	0.94454612
91	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.94289317
92	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.91704134
93	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.91458129
94	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.90947115
95	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.90619056
96	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.90324189
97	EZH2_22144423_ChIP-Seq_EOC_Human	0.89578143
98	SOX2_19829295_ChIP-Seq_ESCs_Human	0.88840160
99	NANOG_19829295_ChIP-Seq_ESCs_Human	0.88840160
100	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.88800664

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004133_heterotaxia	5.62755052
2	MP0002837_dystrophic_cardiac_calcinosis	3.37750291
3	MP0000569_abnormal_digit_pigmentation	3.19490157
4	MP0003195_calcinosis	3.14662686
5	MP0002938_white_spotting	3.08789593
6	MP0002736_abnormal_nociception_after	3.06062595
7	MP0000383_abnormal_hair_follicle	3.01609406
8	MP0000566_synostosis	2.87749572
9	MP0000013_abnormal_adipose_tissue	2.83621254
10	MP0001968_abnormal_touch/_nociception	2.72810248
11	MP0003252_abnormal_bile_duct	2.63978798
12	MP0003787_abnormal_imprinting	2.47442149
13	MP0005551_abnormal_eye_electrophysiolog	2.39295413
14	MP0003880_abnormal_central_pattern	2.34826402
15	MP0004859_abnormal_synaptic_plasticity	2.26366741
16	MP0008877_abnormal_DNA_methylation	2.18739922
17	MP0002909_abnormal_adrenal_gland	2.14610714
18	MP0008961_abnormal_basal_metabolism	2.08930495
19	MP0010678_abnormal_skin_adnexa	2.07656643
20	MP0001986_abnormal_taste_sensitivity	2.06671902
21	MP0008058_abnormal_DNA_repair	1.84997214
22	MP0005646_abnormal_pituitary_gland	1.76224318
23	MP0009745_abnormal_behavioral_response	1.75221056
24	MP0009046_muscle_twitch	1.72789253
25	MP0010030_abnormal_orbit_morphology	1.66174038
26	MP0003693_abnormal_embryo_hatching	1.61451750
27	MP0001486_abnormal_startle_reflex	1.57648138
28	MP0000003_abnormal_adipose_tissue	1.57637434
29	MP0001485_abnormal_pinna_reflex	1.55538635
30	MP0003646_muscle_fatigue	1.53166673
31	MP0001529_abnormal_vocalization	1.52096909
32	MP0004885_abnormal_endolymph	1.46914849
33	MP0003656_abnormal_erythrocyte_physiolo	1.46370715
34	MP0002064_seizures	1.43884622
35	MP0002272_abnormal_nervous_system	1.40675595
36	MP0003718_maternal_effect	1.40515850
37	MP0005084_abnormal_gallbladder_morpholo	1.36402446
38	MP0003011_delayed_dark_adaptation	1.31771045
39	MP0005360_urolithiasis	1.31170116
40	MP0002063_abnormal_learning/memory/cond	1.30363270
41	MP0004130_abnormal_muscle_cell	1.28891412
42	MP0004924_abnormal_behavior	1.28257496
43	MP0005386_behavior/neurological_phenoty	1.28257496
44	MP0001440_abnormal_grooming_behavior	1.26439751
45	MP0003635_abnormal_synaptic_transmissio	1.20077621
46	MP0000230_abnormal_systemic_arterial	1.20036700
47	MP0008775_abnormal_heart_ventricle	1.18990112
48	MP0006276_abnormal_autonomic_nervous	1.13857417
49	MP0003119_abnormal_digestive_system	1.11344866
50	MP0008875_abnormal_xenobiotic_pharmacok	1.11292443
51	MP0001501_abnormal_sleep_pattern	1.08749555
52	MP0006035_abnormal_mitochondrial_morpho	1.08335864
53	MP0003941_abnormal_skin_development	1.07111879
54	MP0008872_abnormal_physiological_respon	1.00602645
55	MP0001346_abnormal_lacrimal_gland	1.00408646
56	MP0002733_abnormal_thermal_nociception	0.99921323
57	MP0002229_neurodegeneration	0.94645705
58	MP0000631_abnormal_neuroendocrine_gland	0.92127928
59	MP0002735_abnormal_chemical_nociception	0.91733387
60	MP0002638_abnormal_pupillary_reflex	0.91544452
61	MP0004142_abnormal_muscle_tone	0.91175350
62	MP0005332_abnormal_amino_acid	0.90318043
63	MP0002067_abnormal_sensory_capabilities	0.90079752
64	MP0003121_genomic_imprinting	0.87613560
65	MP0004742_abnormal_vestibular_system	0.85800646
66	MP0000470_abnormal_stomach_morphology	0.84310576
67	MP0002928_abnormal_bile_duct	0.84286971
68	MP0000026_abnormal_inner_ear	0.83756789
69	MP0005195_abnormal_posterior_eye	0.82032291
70	MP0002572_abnormal_emotion/affect_behav	0.80742636
71	MP0010386_abnormal_urinary_bladder	0.80137982
72	MP0000778_abnormal_nervous_system	0.78928611
73	MP0001324_abnormal_eye_pigmentation	0.78888851
74	MP0001970_abnormal_pain_threshold	0.78684244
75	MP0004215_abnormal_myocardial_fiber	0.78319000
76	MP0002152_abnormal_brain_morphology	0.77521322
77	MP0005085_abnormal_gallbladder_physiolo	0.75706713
78	MP0002752_abnormal_somatic_nervous	0.75353205
79	MP0005395_other_phenotype	0.75322011
80	MP0001299_abnormal_eye_distance/	0.75038298
81	MP0001666_abnormal_nutrient_absorption	0.73028022
82	MP0000371_diluted_coat_color	0.72968581
83	MP0001944_abnormal_pancreas_morphology	0.72813520
84	MP0005334_abnormal_fat_pad	0.71487061
85	MP0002102_abnormal_ear_morphology	0.70905574
86	MP0003172_abnormal_lysosome_physiology	0.70281146
87	MP0000733_abnormal_muscle_development	0.70145635
88	MP0005253_abnormal_eye_physiology	0.69509716
89	MP0005164_abnormal_response_to	0.69244858
90	MP0002882_abnormal_neuron_morphology	0.68999721
91	MP0005376_homeostasis/metabolism_phenot	0.68807287
92	MP0006072_abnormal_retinal_apoptosis	0.68801743
93	MP0005448_abnormal_energy_balance	0.66964555
94	MP0006138_congestive_heart_failure	0.66118763
95	MP0002751_abnormal_autonomic_nervous	0.62514819
96	MP0003329_amyloid_beta_deposits	0.62494788
97	MP0005636_abnormal_mineral_homeostasis	0.62277545
98	MP0005408_hypopigmentation	0.60939005
99	MP0002734_abnormal_mechanical_nocicepti	0.60727925
100	MP0000015_abnormal_ear_pigmentation	0.60569150

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Action tremor (HP:0002345)	7.14383791
2	Genetic anticipation (HP:0003743)	6.16358443
3	Progressive cerebellar ataxia (HP:0002073)	5.10436264
4	Pendular nystagmus (HP:0012043)	4.25621159
5	Abnormality of incisor morphology (HP:0011063)	3.91145338
6	Congenital stationary night blindness (HP:0007642)	3.86757430
7	Aplasia/Hypoplasia of the tongue (HP:0010295)	3.77159383
8	Congenital sensorineural hearing impairment (HP:0008527)	3.61114529
9	Dysmetric saccades (HP:0000641)	3.57291459
10	Rib fusion (HP:0000902)	3.38308804
11	Pancreatic fibrosis (HP:0100732)	3.31146736
12	Hyperventilation (HP:0002883)	3.29305039
13	Megalencephaly (HP:0001355)	3.23686164
14	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.16908999
15	Aplasia involving bones of the extremities (HP:0009825)	3.05413601
16	Aplasia involving bones of the upper limbs (HP:0009823)	3.05413601
17	Aplasia of the phalanges of the hand (HP:0009802)	3.05413601
18	Abnormality of midbrain morphology (HP:0002418)	2.86075942
19	Molar tooth sign on MRI (HP:0002419)	2.86075942
20	Pancreatic cysts (HP:0001737)	2.80010473
21	Abnormality of the hepatic vasculature (HP:0006707)	2.71079287
22	Truncal obesity (HP:0001956)	2.69280866
23	Preaxial foot polydactyly (HP:0001841)	2.68655033
24	Abnormality of the incisor (HP:0000676)	2.67277289
25	Short 1st metacarpal (HP:0010034)	2.66590020
26	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.66590020
27	Fibular aplasia (HP:0002990)	2.63059070
28	Short tibia (HP:0005736)	2.59988300
29	Abnormality of the thoracic spine (HP:0100711)	2.59778438
30	Fair hair (HP:0002286)	2.53057325
31	True hermaphroditism (HP:0010459)	2.52771655
32	Impaired proprioception (HP:0010831)	2.47776132
33	Nephronophthisis (HP:0000090)	2.43071606
34	Protruding tongue (HP:0010808)	2.38691129
35	Abnormality of macular pigmentation (HP:0008002)	2.37698440
36	Ulnar bowing (HP:0003031)	2.36325708
37	Vitreoretinal degeneration (HP:0000655)	2.35369931
38	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.32945737
39	Prostate neoplasm (HP:0100787)	2.32501438
40	Absence seizures (HP:0002121)	2.32363609
41	Scotoma (HP:0000575)	2.31599480
42	Abnormality of the 1st metacarpal (HP:0010009)	2.30853100
43	Stomach cancer (HP:0012126)	2.27643998
44	Postural instability (HP:0002172)	2.26289614
45	Severe visual impairment (HP:0001141)	2.25843653
46	Dysdiadochokinesis (HP:0002075)	2.25796785
47	Rectovaginal fistula (HP:0000143)	2.24945411
48	Rectal fistula (HP:0100590)	2.24945411
49	Papillary thyroid carcinoma (HP:0002895)	2.24430703
50	Postural tremor (HP:0002174)	2.23714914
51	Vaginal fistula (HP:0004320)	2.23686581
52	Clumsiness (HP:0002312)	2.22435612
53	Gaze-evoked nystagmus (HP:0000640)	2.19848263
54	Hypoplasia of the pons (HP:0012110)	2.17960374
55	Decreased subcutaneous fat (HP:0001002)	2.16840823
56	Concave nail (HP:0001598)	2.14813297
57	Keratoconus (HP:0000563)	2.11684331
58	Increased corneal curvature (HP:0100692)	2.11684331
59	Synostosis involving the elbow (HP:0003938)	2.09752676
60	Humeroradial synostosis (HP:0003041)	2.09752676
61	Relative macrocephaly (HP:0004482)	2.08956515
62	Intestinal fistula (HP:0100819)	2.08697835
63	Polymicrogyria (HP:0002126)	2.08131524
64	Chronic hepatic failure (HP:0100626)	2.08094095
65	Supernumerary spleens (HP:0009799)	2.05114781
66	Low anterior hairline (HP:0000294)	2.04144621
67	Abnormality of the pons (HP:0007361)	2.02602579
68	Renal cortical cysts (HP:0000803)	2.00361615
69	Long foot (HP:0001833)	1.99998281
70	Slow saccadic eye movements (HP:0000514)	1.98999479
71	Absent radius (HP:0003974)	1.97407938
72	Bronchomalacia (HP:0002780)	1.96830277
73	Death in childhood (HP:0003819)	1.94767560
74	Postaxial foot polydactyly (HP:0001830)	1.93749179
75	Abnormality of vision evoked potentials (HP:0000649)	1.91828791
76	Hypoproteinemia (HP:0003075)	1.90388543
77	Broad-based gait (HP:0002136)	1.90248115
78	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.89786519
79	Hypoplasia of the brainstem (HP:0002365)	1.89229288
80	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.89229288
81	Trigonocephaly (HP:0000243)	1.87949959
82	Aplasia involving forearm bones (HP:0009822)	1.86351743
83	Absent forearm bone (HP:0003953)	1.86351743
84	Sclerocornea (HP:0000647)	1.83877289
85	Preaxial hand polydactyly (HP:0001177)	1.83348690
86	Stenosis of the external auditory canal (HP:0000402)	1.82367759
87	Generalized myoclonic seizures (HP:0002123)	1.82096286
88	Anomalous pulmonary venous return (HP:0010772)	1.80974440
89	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	1.80394330
90	Focal seizures (HP:0007359)	1.79581049
91	Hyperlipoproteinemia (HP:0010980)	1.79449674
92	Abnormality of the aortic arch (HP:0012303)	1.78755259
93	Abnormality of the renal medulla (HP:0100957)	1.78075339
94	Chorioretinal atrophy (HP:0000533)	1.78042861
95	Cutaneous finger syndactyly (HP:0010554)	1.75297564
96	Impaired vibratory sensation (HP:0002495)	1.74401292
97	Rhabdomyosarcoma (HP:0002859)	1.74382334
98	Microglossia (HP:0000171)	1.73514228
99	Septate vagina (HP:0001153)	1.73284172
100	Long clavicles (HP:0000890)	1.72995338

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	8.50396572
2	CDK19	5.50605258
3	OXSR1	3.01989369
4	WNK3	3.01930790
5	FRK	2.92736401
6	CCNB1	2.90873603
7	INSRR	2.83941130
8	TNIK	2.66488000
9	NTRK3	1.81545930
10	STK38L	1.81381460
11	BCKDK	1.78303303
12	SIK2	1.73738614
13	MAP3K9	1.72754916
14	NUAK1	1.70646201
15	MKNK2	1.66460241
16	ACVR1B	1.66405623
17	PRKD2	1.61180341
18	MARK1	1.56609095
19	GRK1	1.49328581
20	FGFR2	1.48141664
21	NTRK2	1.41825303
22	MAP3K7	1.40275717
23	FGFR1	1.34594641
24	STK38	1.25182948
25	STK3	1.19890626
26	BCR	1.13715484
27	BMPR1B	1.13198579
28	MELK	1.13006083
29	SIK3	1.10770041
30	STK24	1.03658515
31	PRKCG	0.96572632
32	ADRBK2	0.96074965
33	WNK4	0.94280943
34	CAMK1D	0.89279663
35	ADRBK1	0.83262915
36	TGFBR1	0.75000306
37	SGK3	0.73661627
38	CDK11A	0.72344911
39	MKNK1	0.68781413
40	MAPK13	0.68739350
41	PRKCZ	0.65822176
42	CAMKK2	0.64610738
43	PRKAA2	0.64144636
44	PAK1	0.63059055
45	SRPK1	0.62172082
46	TAF1	0.60220478
47	CASK	0.53116313
48	STK11	0.52588500
49	MAPKAPK5	0.52520539
50	PDPK1	0.52473738
51	PAK3	0.50378810
52	TIE1	0.50281628
53	CDK15	0.50263979
54	NLK	0.49811657
55	CSNK1G2	0.48964514
56	TNK2	0.48377989
57	CDK18	0.47912033
58	CHUK	0.47239774
59	CHEK1	0.47009171
60	CSNK1G1	0.46187835
61	MET	0.45745213
62	PBK	0.45678269
63	RET	0.43885493
64	CSNK1G3	0.43735491
65	MAP3K4	0.43502726
66	PRKACB	0.42697788
67	DYRK2	0.42261770
68	CAMK1G	0.42146879
69	TXK	0.41383866
70	CAMKK1	0.41022427
71	MAPK9	0.40091032
72	PRKAA1	0.38778033
73	CDK5	0.36392507
74	EPHB2	0.36281518
75	MAPK15	0.35104366
76	VRK2	0.34691278
77	LATS1	0.34573786
78	NEK2	0.34221080
79	BRSK2	0.33855836
80	CDK14	0.32714510
81	CAMK2B	0.32643174
82	MAPK10	0.31279654
83	PRKACG	0.31106463
84	GSK3B	0.30613369
85	PDK2	0.30570426
86	CSNK1A1L	0.29125927
87	GRK5	0.29006696
88	MAP3K14	0.28330285
89	ERBB2	0.27922430
90	MARK3	0.27297527
91	BTK	0.26531826
92	PRKCH	0.25348930
93	PRKACA	0.24855140
94	CHEK2	0.24738982
95	CDK1	0.24132172
96	MUSK	0.23333840
97	NTRK1	0.22982933
98	AKT1	0.22549612
99	DAPK2	0.21773130
100	FLT3	0.21080432

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.55257812
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.37553785
3	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	4.27185652
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.33036020
5	Phototransduction_Homo sapiens_hsa04744	3.15013727
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.12219310
7	Caffeine metabolism_Homo sapiens_hsa00232	2.87123746
8	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.52387640
9	Nicotine addiction_Homo sapiens_hsa05033	2.12122445
10	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.11393932
11	Butanoate metabolism_Homo sapiens_hsa00650	2.05891104
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.94079146
13	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.92949429
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.90103871
15	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.89421579
16	Chemical carcinogenesis_Homo sapiens_hsa05204	1.87117775
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.70202365
18	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.69954846
19	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.68052606
20	Retinol metabolism_Homo sapiens_hsa00830	1.66230889
21	Non-homologous end-joining_Homo sapiens_hsa03450	1.65789300
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.60079269
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.55485173
24	Sulfur relay system_Homo sapiens_hsa04122	1.53310647
25	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.49372716
26	Olfactory transduction_Homo sapiens_hsa04740	1.46831285
27	Lysine degradation_Homo sapiens_hsa00310	1.42754018
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.34124845
29	Arginine biosynthesis_Homo sapiens_hsa00220	1.31741352
30	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.24464540
31	Phenylalanine metabolism_Homo sapiens_hsa00360	1.22457922
32	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.13950615
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.11540311
34	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.97883223
35	Morphine addiction_Homo sapiens_hsa05032	0.97575996
36	Glutamatergic synapse_Homo sapiens_hsa04724	0.95516122
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.95198142
38	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.93308266
39	Regulation of autophagy_Homo sapiens_hsa04140	0.92989742
40	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.91234213
41	Tyrosine metabolism_Homo sapiens_hsa00350	0.90199597
42	Fat digestion and absorption_Homo sapiens_hsa04975	0.84678642
43	Long-term depression_Homo sapiens_hsa04730	0.83817153
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.82387458
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71891866
46	Salivary secretion_Homo sapiens_hsa04970	0.70730325
47	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.70073521
48	GABAergic synapse_Homo sapiens_hsa04727	0.69419381
49	PPAR signaling pathway_Homo sapiens_hsa03320	0.68482130
50	Complement and coagulation cascades_Homo sapiens_hsa04610	0.68015885
51	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.63689252
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.63095329
53	Type II diabetes mellitus_Homo sapiens_hsa04930	0.61751690
54	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.60988442
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.60645212
56	Taste transduction_Homo sapiens_hsa04742	0.59029505
57	Calcium signaling pathway_Homo sapiens_hsa04020	0.55013720
58	Cholinergic synapse_Homo sapiens_hsa04725	0.53496542
59	mRNA surveillance pathway_Homo sapiens_hsa03015	0.53429974
60	cAMP signaling pathway_Homo sapiens_hsa04024	0.52146784
61	ABC transporters_Homo sapiens_hsa02010	0.51866774
62	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.51390876
63	Dopaminergic synapse_Homo sapiens_hsa04728	0.49531517
64	Pyruvate metabolism_Homo sapiens_hsa00620	0.49120909
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.48899531
66	RNA degradation_Homo sapiens_hsa03018	0.47574363
67	Basal transcription factors_Homo sapiens_hsa03022	0.45235079
68	Circadian entrainment_Homo sapiens_hsa04713	0.45060924
69	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.44284980
70	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.44010091
71	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.43817654
72	Peroxisome_Homo sapiens_hsa04146	0.42921613
73	Histidine metabolism_Homo sapiens_hsa00340	0.42666819
74	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.42410155
75	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.42281217
76	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.40738832
77	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.39680496
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39019553
79	Propanoate metabolism_Homo sapiens_hsa00640	0.38111432
80	Serotonergic synapse_Homo sapiens_hsa04726	0.37802583
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.37554448
82	Renin-angiotensin system_Homo sapiens_hsa04614	0.36762524
83	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.36620350
84	Bile secretion_Homo sapiens_hsa04976	0.30690269
85	Axon guidance_Homo sapiens_hsa04360	0.29044436
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.28375940
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.26976853
88	Hippo signaling pathway_Homo sapiens_hsa04390	0.25718016
89	RNA polymerase_Homo sapiens_hsa03020	0.24541641
90	Steroid biosynthesis_Homo sapiens_hsa00100	0.24267369
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.23542082
92	ECM-receptor interaction_Homo sapiens_hsa04512	0.23538866
93	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.22110569
94	Purine metabolism_Homo sapiens_hsa00230	0.21986857
95	Oocyte meiosis_Homo sapiens_hsa04114	0.21331305
96	Ras signaling pathway_Homo sapiens_hsa04014	0.20755854
97	Metabolic pathways_Homo sapiens_hsa01100	0.20286365
98	Base excision repair_Homo sapiens_hsa03410	0.19338075
99	Renal cell carcinoma_Homo sapiens_hsa05211	0.18367249
100	Cocaine addiction_Homo sapiens_hsa05030	0.17605086

MTND6P21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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