MTND6P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to cadmium ion (GO:0071276)5.98712356
2synaptic vesicle exocytosis (GO:0016079)5.60836403
3central nervous system myelination (GO:0022010)5.44924179
4axon ensheathment in central nervous system (GO:0032291)5.44924179
5glutamate secretion (GO:0014047)5.34258423
6regulation of response to food (GO:0032095)5.20244731
7cellular response to nitric oxide (GO:0071732)5.19827327
8cellular potassium ion homeostasis (GO:0030007)5.19394637
9potassium ion homeostasis (GO:0055075)5.06349082
10potassium ion import (GO:0010107)5.06324761
11regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00435.03062217
12cellular response to leptin stimulus (GO:0044320)4.99134252
13response to leptin (GO:0044321)4.86249628
14regulation of protein glycosylation (GO:0060049)4.81001984
15regulation of female receptivity (GO:0045924)4.54706951
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.39438359
17cholesterol catabolic process (GO:0006707)4.19707785
18sterol catabolic process (GO:0016127)4.19707785
19regulation of oxidative phosphorylation (GO:0002082)4.04750016
20gamma-aminobutyric acid transport (GO:0015812)4.04456630
21cellular response to zinc ion (GO:0071294)3.98057142
22neurotransmitter secretion (GO:0007269)3.97453439
23cellular response to reactive nitrogen species (GO:1902170)3.95090398
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.92918099
25female mating behavior (GO:0060180)3.92249812
26synaptic vesicle docking involved in exocytosis (GO:0016081)3.89392008
27regulation of sensory perception of pain (GO:0051930)3.86458479
28regulation of sensory perception (GO:0051931)3.86458479
29response to nitric oxide (GO:0071731)3.81878197
30neurotransmitter uptake (GO:0001504)3.80066575
31postsynaptic membrane organization (GO:0001941)3.74281621
32L-amino acid import (GO:0043092)3.70838857
33negative regulation of response to food (GO:0032096)3.65840662
34negative regulation of appetite (GO:0032099)3.65840662
35cellular zinc ion homeostasis (GO:0006882)3.63259007
36cellular response to superoxide (GO:0071451)3.62655515
37cellular response to oxygen radical (GO:0071450)3.62655515
38removal of superoxide radicals (GO:0019430)3.62655515
39auditory behavior (GO:0031223)3.61417613
40positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.55228839
41regulation of synapse structural plasticity (GO:0051823)3.53310963
42regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.48808883
43calcium ion-dependent exocytosis (GO:0017156)3.42415478
44activation of protein kinase B activity (GO:0032148)3.41484100
45positive regulation of potassium ion transmembrane transport (GO:1901381)3.41291515
46respiratory electron transport chain (GO:0022904)3.39969946
47positive regulation of synapse maturation (GO:0090129)3.35716875
48sleep (GO:0030431)3.34904625
49detection of calcium ion (GO:0005513)3.34794342
50cellular response to electrical stimulus (GO:0071257)3.34586570
51electron transport chain (GO:0022900)3.34436622
52positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.31943841
53astrocyte development (GO:0014002)3.31403375
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29645916
55regulation of cell communication by electrical coupling (GO:0010649)3.25509896
56positive regulation of dendritic spine development (GO:0060999)3.24656536
57insulin secretion (GO:0030073)3.24575085
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.24062106
59regulation of neurotransmitter levels (GO:0001505)3.23492593
60positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.23119668
61negative regulation of reactive oxygen species metabolic process (GO:2000378)3.21966868
62response to histamine (GO:0034776)3.21489533
63sodium ion export (GO:0071436)3.20008267
64positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.18967524
65neurotransmitter transport (GO:0006836)3.15405552
66membrane repolarization (GO:0086009)3.14607265
67cAMP-mediated signaling (GO:0019933)3.12981389
68zinc ion homeostasis (GO:0055069)3.12832611
69ATP synthesis coupled proton transport (GO:0015986)3.10684191
70energy coupled proton transport, down electrochemical gradient (GO:0015985)3.10684191
71positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.06983326
72regulation of glutamate receptor signaling pathway (GO:1900449)3.00315193
73positive regulation of potassium ion transport (GO:0043268)2.98688671
74substrate-independent telencephalic tangential migration (GO:0021826)2.98400023
75substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.98400023
76regulation of voltage-gated calcium channel activity (GO:1901385)2.96505310
77neurofilament cytoskeleton organization (GO:0060052)2.92985823
78positive regulation of meiosis (GO:0045836)2.92900185
79positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90908742
80negative regulation of necrotic cell death (GO:0060547)2.90300637
81response to superoxide (GO:0000303)2.90117649
82response to auditory stimulus (GO:0010996)2.87974820
83membrane hyperpolarization (GO:0060081)2.86564403
84synaptic vesicle maturation (GO:0016188)2.85018645
85startle response (GO:0001964)2.84496836
86steroid catabolic process (GO:0006706)2.79407804
87ionotropic glutamate receptor signaling pathway (GO:0035235)2.79347736
88amino acid import (GO:0043090)2.78552505
89relaxation of smooth muscle (GO:0044557)2.78506491
90glutamate receptor signaling pathway (GO:0007215)2.78460397
91cellular sodium ion homeostasis (GO:0006883)2.77201643
92regulation of synapse maturation (GO:0090128)2.77104647
93regulation of cellular respiration (GO:0043457)2.77084208
94erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.76263561
95L-phenylalanine catabolic process (GO:0006559)2.76263561
96one-carbon compound transport (GO:0019755)2.74142388
97regulation of synaptic vesicle exocytosis (GO:2000300)2.73345944
98synaptic transmission, glutamatergic (GO:0035249)2.72656174
99urinary tract smooth muscle contraction (GO:0014848)2.72271642
100transmission of nerve impulse (GO:0019226)2.70995897

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.01442430
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.76690031
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63104430
4REST_21632747_ChIP-Seq_MESCs_Mouse2.62242470
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.57797561
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.55265456
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.46953825
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45756444
9GBX2_23144817_ChIP-Seq_PC3_Human2.33347784
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25921661
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24078957
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18577425
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13339847
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.11849076
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.02580615
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00946505
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.00926047
18REST_18959480_ChIP-ChIP_MESCs_Mouse1.98696744
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95980292
20RARB_27405468_Chip-Seq_BRAIN_Mouse1.91065017
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91043342
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91043342
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89641220
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89393207
25RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.86514747
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84984615
27DROSHA_22980978_ChIP-Seq_HELA_Human1.78837899
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.76875944
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73014666
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69654307
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68658767
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58367146
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57864216
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52240565
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.44834482
36AR_21572438_ChIP-Seq_LNCaP_Human1.36891849
37P300_19829295_ChIP-Seq_ESCs_Human1.34242434
38RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34119039
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33056225
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.32146183
41TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.30084246
42HTT_18923047_ChIP-ChIP_STHdh_Human1.24991015
43AR_25329375_ChIP-Seq_VCAP_Human1.24220497
44SMAD4_21799915_ChIP-Seq_A2780_Human1.19437160
45TAF15_26573619_Chip-Seq_HEK293_Human1.17363322
46TCF4_23295773_ChIP-Seq_U87_Human1.16450407
47CTCF_27219007_Chip-Seq_Bcells_Human1.14906965
48BCAT_22108803_ChIP-Seq_LS180_Human1.13619841
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13485757
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12321980
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11049711
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09397512
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09201968
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08222315
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08061586
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07689934
57RNF2_27304074_Chip-Seq_NSC_Mouse1.07177325
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.06887772
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05189505
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.05186668
61SMAD3_21741376_ChIP-Seq_ESCs_Human1.04586267
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04449657
63CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04322229
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.04146205
65CBP_20019798_ChIP-Seq_JUKART_Human1.01018561
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01018561
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98905229
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97944536
69FUS_26573619_Chip-Seq_HEK293_Human0.97765985
70WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96991269
71EGR1_19032775_ChIP-ChIP_M12_Human0.96928532
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96522973
73VDR_22108803_ChIP-Seq_LS180_Human0.96356104
74STAT3_23295773_ChIP-Seq_U87_Human0.95077874
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93858552
76AR_19668381_ChIP-Seq_PC3_Human0.93738682
77TAF2_19829295_ChIP-Seq_ESCs_Human0.90964004
78TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90326272
79TCF4_22108803_ChIP-Seq_LS180_Human0.89212682
80RXR_22108803_ChIP-Seq_LS180_Human0.89140215
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89066466
82POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89034730
83MYC_19829295_ChIP-Seq_ESCs_Human0.88678641
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88177439
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87309879
86CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86752168
87NANOG_19829295_ChIP-Seq_ESCs_Human0.86559362
88SOX2_19829295_ChIP-Seq_ESCs_Human0.86559362
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85657312
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85064061
91SOX2_21211035_ChIP-Seq_LN229_Gbm0.85000975
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84878476
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84056566
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84027229
95RUNX2_22187159_ChIP-Seq_PCA_Human0.83568820
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83227651
97JUN_21703547_ChIP-Seq_K562_Human0.83022857
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82786229
99P53_22387025_ChIP-Seq_ESCs_Mouse0.82731349
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82475559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004885_abnormal_endolymph4.23732827
2MP0003880_abnormal_central_pattern3.87456772
3MP0004043_abnormal_pH_regulation3.81413448
4MP0004859_abnormal_synaptic_plasticity3.77097242
5MP0003787_abnormal_imprinting3.63739297
6MP0002064_seizures3.17614961
7MP0003635_abnormal_synaptic_transmissio2.93380519
8MP0009379_abnormal_foot_pigmentation2.88636511
9MP0004270_analgesia2.83962842
10MP0009780_abnormal_chondrocyte_physiolo2.82092977
11MP0009745_abnormal_behavioral_response2.78445420
12MP0002272_abnormal_nervous_system2.65886333
13MP0008877_abnormal_DNA_methylation2.48244175
14MP0005646_abnormal_pituitary_gland2.47055203
15MP0001485_abnormal_pinna_reflex2.41996480
16MP0001486_abnormal_startle_reflex2.34107191
17MP0003879_abnormal_hair_cell2.07828390
18MP0001501_abnormal_sleep_pattern2.07477993
19MP0009046_muscle_twitch2.04596630
20MP0002063_abnormal_learning/memory/cond2.04225184
21MP0001968_abnormal_touch/_nociception2.01492491
22MP0002734_abnormal_mechanical_nocicepti1.99273676
23MP0002572_abnormal_emotion/affect_behav1.89142498
24MP0005423_abnormal_somatic_nervous1.87066516
25MP0001440_abnormal_grooming_behavior1.84483800
26MP0001905_abnormal_dopamine_level1.82649950
27MP0005551_abnormal_eye_electrophysiolog1.76360667
28MP0001970_abnormal_pain_threshold1.75002656
29MP0001984_abnormal_olfaction1.70117444
30MP0010386_abnormal_urinary_bladder1.69933133
31MP0002733_abnormal_thermal_nociception1.69661133
32MP0001188_hyperpigmentation1.60618851
33MP0003633_abnormal_nervous_system1.57615112
34MP0003123_paternal_imprinting1.55035691
35MP0008569_lethality_at_weaning1.54985879
36MP0002557_abnormal_social/conspecific_i1.54222226
37MP0003690_abnormal_glial_cell1.54074260
38MP0006276_abnormal_autonomic_nervous1.49996215
39MP0001963_abnormal_hearing_physiology1.45875897
40MP0002736_abnormal_nociception_after1.44203276
41MP0006036_abnormal_mitochondrial_physio1.42362303
42MP0002876_abnormal_thyroid_physiology1.41098978
43MP0002909_abnormal_adrenal_gland1.38710948
44MP0002837_dystrophic_cardiac_calcinosis1.38642053
45MP0008872_abnormal_physiological_respon1.36237178
46MP0000955_abnormal_spinal_cord1.32623882
47MP0004147_increased_porphyrin_level1.31479007
48MP0002067_abnormal_sensory_capabilities1.28231271
49MP0001502_abnormal_circadian_rhythm1.20700026
50MP0002229_neurodegeneration1.20551898
51MP0003878_abnormal_ear_physiology1.15680295
52MP0005377_hearing/vestibular/ear_phenot1.15680295
53MP0006072_abnormal_retinal_apoptosis1.15544205
54MP0003283_abnormal_digestive_organ1.14325939
55MP0002066_abnormal_motor_capabilities/c1.13643021
56MP0004742_abnormal_vestibular_system1.11819005
57MP0002882_abnormal_neuron_morphology1.11416127
58MP0005645_abnormal_hypothalamus_physiol1.11171303
59MP0003631_nervous_system_phenotype1.11083453
60MP0002735_abnormal_chemical_nociception1.09539614
61MP0000026_abnormal_inner_ear1.08314379
62MP0003121_genomic_imprinting1.07844853
63MP0005670_abnormal_white_adipose1.05814271
64MP0005636_abnormal_mineral_homeostasis1.05367418
65MP0005332_abnormal_amino_acid1.01929171
66MP0001765_abnormal_ion_homeostasis1.01769531
67MP0003329_amyloid_beta_deposits0.98063398
68MP0004811_abnormal_neuron_physiology0.93730153
69MP0000013_abnormal_adipose_tissue0.92873147
70MP0005386_behavior/neurological_phenoty0.90841971
71MP0004924_abnormal_behavior0.90841971
72MP0004142_abnormal_muscle_tone0.90291200
73MP0005360_urolithiasis0.88577318
74MP0004145_abnormal_muscle_electrophysio0.87830245
75MP0001664_abnormal_digestion0.87671584
76MP0004019_abnormal_vitamin_homeostasis0.87350049
77MP0010329_abnormal_lipoprotein_level0.87121748
78MP0002184_abnormal_innervation0.86668131
79MP0003122_maternal_imprinting0.84530564
80MP0000778_abnormal_nervous_system0.84259621
81MP0002089_abnormal_postnatal_growth/wei0.84221109
82MP0005535_abnormal_body_temperature0.82180022
83MP0000230_abnormal_systemic_arterial0.81688311
84MP0005253_abnormal_eye_physiology0.80292384
85MP0003195_calcinosis0.79977251
86MP0002752_abnormal_somatic_nervous0.78896704
87MP0000920_abnormal_myelination0.78381156
88MP0001756_abnormal_urination0.78364296
89MP0001986_abnormal_taste_sensitivity0.74174149
90MP0000631_abnormal_neuroendocrine_gland0.72105864
91MP0004215_abnormal_myocardial_fiber0.70687644
92MP0003866_abnormal_defecation0.69883682
93MP0003011_delayed_dark_adaptation0.69256796
94MP0005166_decreased_susceptibility_to0.68346080
95MP0002693_abnormal_pancreas_physiology0.68096125
96MP0003632_abnormal_nervous_system0.67994020
97MP0004085_abnormal_heartbeat0.66793806
98MP0002069_abnormal_eating/drinking_beha0.64958323
99MP0002163_abnormal_gland_morphology0.63124784
100MP0003075_altered_response_to0.62027340

Predicted human phenotypes

RankGene SetZ-score
1Nonprogressive disorder (HP:0003680)5.62749867
2Increased circulating renin level (HP:0000848)4.90838746
3Focal motor seizures (HP:0011153)4.62010820
4Focal seizures (HP:0007359)4.53474545
5Abnormality of binocular vision (HP:0011514)4.41925660
6Diplopia (HP:0000651)4.41925660
7Myokymia (HP:0002411)4.21390486
8Metabolic alkalosis (HP:0200114)3.99042391
9Acute necrotizing encephalopathy (HP:0006965)3.89650631
10Abnormal eating behavior (HP:0100738)3.86846592
11Action tremor (HP:0002345)3.74047921
12Epileptic encephalopathy (HP:0200134)3.60868496
13Progressive macrocephaly (HP:0004481)3.38403291
14Febrile seizures (HP:0002373)3.32431667
15Hypomagnesemia (HP:0002917)3.30317830
16Absence seizures (HP:0002121)3.29564753
17Dialeptic seizures (HP:0011146)3.29374597
18Abnormality of magnesium homeostasis (HP:0004921)3.27059580
19Hemiparesis (HP:0001269)3.26935762
20Abnormal mitochondria in muscle tissue (HP:0008316)3.25844591
21Atonic seizures (HP:0010819)3.22711945
22Peripheral hypomyelination (HP:0007182)3.09579242
23Acute encephalopathy (HP:0006846)3.09082756
24Abnormal drinking behavior (HP:0030082)2.96273490
25Polydipsia (HP:0001959)2.96273490
26Ankle clonus (HP:0011448)2.89818396
27Progressive cerebellar ataxia (HP:0002073)2.89411858
28Papilledema (HP:0001085)2.88365955
29Hypokalemic alkalosis (HP:0001949)2.87843453
30Generalized tonic-clonic seizures (HP:0002069)2.83904071
31Limb dystonia (HP:0002451)2.83262957
32Abnormality of renin-angiotensin system (HP:0000847)2.74753032
33Polyphagia (HP:0002591)2.72871271
34Epileptiform EEG discharges (HP:0011182)2.72333046
35Mitochondrial inheritance (HP:0001427)2.64916839
36Intention tremor (HP:0002080)2.54251411
37Status epilepticus (HP:0002133)2.52911379
38Ventricular fibrillation (HP:0001663)2.46183500
39Confusion (HP:0001289)2.44631499
40Anxiety (HP:0000739)2.40236674
41Metaphyseal dysplasia (HP:0100255)2.40013583
42Abnormality of aromatic amino acid family metabolism (HP:0004338)2.37262462
43Cerebral edema (HP:0002181)2.33699979
44Hyperaldosteronism (HP:0000859)2.27271072
45Broad-based gait (HP:0002136)2.22005823
46Abnormality of cochlea (HP:0000375)2.20435652
47Increased CSF lactate (HP:0002490)2.18954178
48Syncope (HP:0001279)2.16750837
49Hyperventilation (HP:0002883)2.16307932
50Hyperthyroidism (HP:0000836)2.15743240
51Abnormality of midbrain morphology (HP:0002418)2.14356471
52Molar tooth sign on MRI (HP:0002419)2.14356471
53Dysdiadochokinesis (HP:0002075)2.13969757
54Visual hallucinations (HP:0002367)2.09865099
55Pigmentary retinal degeneration (HP:0001146)2.09841276
56Sleep apnea (HP:0010535)2.06626474
57EEG with generalized epileptiform discharges (HP:0011198)2.06278315
58Gaze-evoked nystagmus (HP:0000640)2.04184337
59Obstructive sleep apnea (HP:0002870)2.04008449
60Leukodystrophy (HP:0002415)2.03258018
61Alkalosis (HP:0001948)2.02741161
62Morphological abnormality of the inner ear (HP:0011390)2.02510044
63Renal salt wasting (HP:0000127)2.00512226
64Delayed CNS myelination (HP:0002188)1.98597700
65Congenital stationary night blindness (HP:0007642)1.97719500
66Bundle branch block (HP:0011710)1.96579441
67Polyuria (HP:0000103)1.94998818
68Abnormality of renal excretion (HP:0011036)1.92825542
69Hyperphosphatemia (HP:0002905)1.92779932
70Megalencephaly (HP:0001355)1.91822497
71Pancreatic fibrosis (HP:0100732)1.91524145
72Hyperparathyroidism (HP:0000843)1.89227856
73Nephronophthisis (HP:0000090)1.85543834
74Abnormal urine output (HP:0012590)1.83956826
75Hepatic necrosis (HP:0002605)1.82552528
76Neurofibrillary tangles (HP:0002185)1.81773257
77Agitation (HP:0000713)1.81078647
783-Methylglutaconic aciduria (HP:0003535)1.80542568
79Congenital, generalized hypertrichosis (HP:0004540)1.80132987
80Medial flaring of the eyebrow (HP:0010747)1.79808969
81Focal dystonia (HP:0004373)1.78376832
82Hyperphosphaturia (HP:0003109)1.78248866
83Hypsarrhythmia (HP:0002521)1.77336773
84Hypoplastic left heart (HP:0004383)1.76990293
85Torticollis (HP:0000473)1.76750442
86Glycosuria (HP:0003076)1.76529190
87Abnormality of urine glucose concentration (HP:0011016)1.76529190
88Supranuclear gaze palsy (HP:0000605)1.75753243
89Optic disc pallor (HP:0000543)1.75160865
90Ulnar claw (HP:0001178)1.74735494
91Postural tremor (HP:0002174)1.74590145
92Clumsiness (HP:0002312)1.74553715
93Truncal ataxia (HP:0002078)1.73872138
94Hemiplegia (HP:0002301)1.73715048
95Prolonged QT interval (HP:0001657)1.72895218
96Delusions (HP:0000746)1.71544879
97Abnormality of calcium-phosphate metabolism (HP:0100530)1.70042472
98Abnormality of renal resorption (HP:0011038)1.69499807
99Genetic anticipation (HP:0003743)1.68539905
100Urinary bladder sphincter dysfunction (HP:0002839)1.66660853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.30616422
2DMPK3.27022838
3PINK13.23277539
4RIPK42.79796970
5MARK12.65423469
6PAK32.65287045
7PAK62.52304815
8BMPR22.43712885
9FRK2.42218055
10UHMK12.04483403
11MINK12.03462166
12PHKG21.87614142
13PHKG11.87614142
14PLK21.86748523
15GRK51.83601998
16PRKD31.80539875
17DAPK21.76355292
18NTRK21.72036825
19TAOK31.69859752
20TLK11.66037472
21CAMKK11.61190823
22MAP3K121.47153825
23LIMK11.45786969
24GRK11.41496278
25PRKCG1.41016471
26MAPK131.40153897
27CAMK2A1.37745963
28CASK1.33937077
29TNK21.30448700
30ADRBK21.24417539
31SGK11.21253247
32CAMK11.21110230
33MAPKAPK31.19496527
34BMPR1B1.19123337
35SGK2231.17306005
36SGK4941.17306005
37CDK51.15942166
38ACVR1B1.15826620
39WNK41.13711274
40TNIK1.10684254
41CAMK2B1.07480181
42SGK21.06807096
43MAP3K41.02984137
44CAMK2G1.02821299
45ABL21.02425664
46STK390.97053070
47EPHA40.96515391
48WNK10.95088166
49CDK140.92685363
50CDK11A0.92599342
51PKN10.92338989
52CSNK1E0.91664543
53NUAK10.90700004
54MAP2K40.89490721
55CDK190.86486300
56PRKG10.86368305
57INSRR0.86046181
58MAP2K60.84778526
59PTK2B0.83861182
60CDK150.83850635
61MAPK120.83612130
62CAMK2D0.81346308
63NTRK10.80913591
64MAP2K70.77333184
65RPS6KA30.76969863
66PRKCQ0.76127717
67TEC0.75970141
68CDK180.74994602
69TESK10.70998926
70MYLK0.69481841
71OXSR10.69114121
72PRKCA0.69059352
73STK380.68270867
74STK160.67134940
75PRKACA0.65595791
76PRKCZ0.65064975
77ADRBK10.64687953
78PIK3CA0.64227494
79STK110.62423694
80TYRO30.61050206
81CSNK1A10.55829044
82PRKCH0.53885727
83SIK20.53832521
84MAPK40.53605332
85MAPK100.53017594
86PRKCE0.52783483
87MAP3K20.49415993
88FES0.49315020
89SGK30.49145276
90MST40.48402106
91PRKD10.47517143
92CDC70.44661495
93PRKCI0.44115442
94PRKG20.43835428
95MARK20.42989517
96PRKACG0.41521650
97PRKACB0.41309270
98HIPK20.41088984
99SYK0.40571211
100ROCK10.38679594

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.50297315
2Insulin secretion_Homo sapiens_hsa049113.26993931
3Oxidative phosphorylation_Homo sapiens_hsa001902.77934687
4Synaptic vesicle cycle_Homo sapiens_hsa047212.75587044
5Cardiac muscle contraction_Homo sapiens_hsa042602.37998301
6Circadian entrainment_Homo sapiens_hsa047132.35439375
7Morphine addiction_Homo sapiens_hsa050322.18606395
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15731175
9GABAergic synapse_Homo sapiens_hsa047272.15421697
10Amphetamine addiction_Homo sapiens_hsa050312.14411202
11Gastric acid secretion_Homo sapiens_hsa049712.11033155
12Mineral absorption_Homo sapiens_hsa049782.09643545
13Long-term potentiation_Homo sapiens_hsa047202.07033458
14Dopaminergic synapse_Homo sapiens_hsa047282.02629711
15Salivary secretion_Homo sapiens_hsa049702.01457124
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91496442
17Parkinsons disease_Homo sapiens_hsa050121.88047346
18Glutamatergic synapse_Homo sapiens_hsa047241.85038730
19Collecting duct acid secretion_Homo sapiens_hsa049661.82755651
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.80602485
21Alzheimers disease_Homo sapiens_hsa050101.77893148
22Renin secretion_Homo sapiens_hsa049241.62458886
23Serotonergic synapse_Homo sapiens_hsa047261.57860661
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50040999
25Folate biosynthesis_Homo sapiens_hsa007901.47544637
26Phototransduction_Homo sapiens_hsa047441.45196897
27Cocaine addiction_Homo sapiens_hsa050301.43809558
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43121982
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40515148
30Oxytocin signaling pathway_Homo sapiens_hsa049211.40227472
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.34729587
32Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.34696126
33Calcium signaling pathway_Homo sapiens_hsa040201.32011176
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31511549
35Cholinergic synapse_Homo sapiens_hsa047251.27884643
36cAMP signaling pathway_Homo sapiens_hsa040241.26088367
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24260221
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24122991
39Pancreatic secretion_Homo sapiens_hsa049721.23736487
40Histidine metabolism_Homo sapiens_hsa003401.21651065
41Olfactory transduction_Homo sapiens_hsa047401.19145991
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18652179
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13313127
44Taste transduction_Homo sapiens_hsa047421.11751157
45beta-Alanine metabolism_Homo sapiens_hsa004101.10618522
46Long-term depression_Homo sapiens_hsa047301.06779914
47Linoleic acid metabolism_Homo sapiens_hsa005911.04972267
48Huntingtons disease_Homo sapiens_hsa050161.00952122
49Arginine and proline metabolism_Homo sapiens_hsa003301.00767235
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99484985
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.98584631
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93745351
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89963367
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89943806
55Tryptophan metabolism_Homo sapiens_hsa003800.89324018
56Bile secretion_Homo sapiens_hsa049760.86458243
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84603381
58Arginine biosynthesis_Homo sapiens_hsa002200.84258382
59Butanoate metabolism_Homo sapiens_hsa006500.83009302
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78833696
61Asthma_Homo sapiens_hsa053100.76672984
62GnRH signaling pathway_Homo sapiens_hsa049120.75147619
63Arachidonic acid metabolism_Homo sapiens_hsa005900.72883908
64Sulfur relay system_Homo sapiens_hsa041220.68784932
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68322971
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68130496
67Thyroid hormone synthesis_Homo sapiens_hsa049180.67844895
68Vitamin B6 metabolism_Homo sapiens_hsa007500.63803860
69Chemical carcinogenesis_Homo sapiens_hsa052040.57022923
70Protein export_Homo sapiens_hsa030600.55366488
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54868522
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.51103816
73Melanogenesis_Homo sapiens_hsa049160.51059800
74Phenylalanine metabolism_Homo sapiens_hsa003600.48097686
75Type I diabetes mellitus_Homo sapiens_hsa049400.46852926
76Ras signaling pathway_Homo sapiens_hsa040140.46129209
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45786050
78Rheumatoid arthritis_Homo sapiens_hsa053230.44693914
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43620901
80Fat digestion and absorption_Homo sapiens_hsa049750.43047603
81Nitrogen metabolism_Homo sapiens_hsa009100.42768808
82Fatty acid degradation_Homo sapiens_hsa000710.41771260
83Ribosome_Homo sapiens_hsa030100.39134836
84MAPK signaling pathway_Homo sapiens_hsa040100.38134467
85Dorso-ventral axis formation_Homo sapiens_hsa043200.37822446
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.35960069
87Glycerolipid metabolism_Homo sapiens_hsa005610.35427378
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34477729
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34301469
90Rap1 signaling pathway_Homo sapiens_hsa040150.34160276
91PPAR signaling pathway_Homo sapiens_hsa033200.33421872
92Glucagon signaling pathway_Homo sapiens_hsa049220.32230854
93Ether lipid metabolism_Homo sapiens_hsa005650.32112445
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31653535
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31409061
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30654270
97Gap junction_Homo sapiens_hsa045400.30527402
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.30249565
99Retinol metabolism_Homo sapiens_hsa008300.29884798
100Estrogen signaling pathway_Homo sapiens_hsa049150.29625050

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