MTNR1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation, alternative pathway (GO:0006957)8.36383658
2blood coagulation, intrinsic pathway (GO:0007597)7.68201278
3phosphate ion transmembrane transport (GO:0035435)7.51384210
4left/right axis specification (GO:0070986)7.27624147
5regulation of bile acid biosynthetic process (GO:0070857)6.99785439
6regulation of protein activation cascade (GO:2000257)6.92170170
7regulation of complement activation (GO:0030449)6.83523117
8embryonic retina morphogenesis in camera-type eye (GO:0060059)6.76364860
9phosphate ion transport (GO:0006817)6.46537819
10negative regulation of sterol transport (GO:0032372)6.36652367
11negative regulation of cholesterol transport (GO:0032375)6.36652367
12regulation of cholesterol esterification (GO:0010872)6.18356440
13low-density lipoprotein particle remodeling (GO:0034374)5.94926708
14high-density lipoprotein particle remodeling (GO:0034375)5.90537144
15regulation of fibrinolysis (GO:0051917)5.77354259
16arginine catabolic process (GO:0006527)5.77221195
17phospholipid efflux (GO:0033700)5.68918024
18imidazole-containing compound metabolic process (GO:0052803)5.66335084
19fibrinolysis (GO:0042730)5.64012121
20phospholipid homeostasis (GO:0055091)5.59717977
21reverse cholesterol transport (GO:0043691)5.57773029
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.52835879
23hepatocyte differentiation (GO:0070365)5.43180516
24urea metabolic process (GO:0019627)5.41968168
25drug catabolic process (GO:0042737)5.36421528
26regulation of sarcomere organization (GO:0060297)5.21224176
27positive regulation of cell cycle checkpoint (GO:1901978)5.10596516
28response to vitamin A (GO:0033189)5.06776153
29urea cycle (GO:0000050)5.04487422
30peptidyl-glutamic acid carboxylation (GO:0017187)4.97314048
31protein carboxylation (GO:0018214)4.97314048
32nitrogen cycle metabolic process (GO:0071941)4.90412629
33omega-hydroxylase P450 pathway (GO:0097267)4.88362816
34plasma lipoprotein particle remodeling (GO:0034369)4.81312959
35protein-lipid complex remodeling (GO:0034368)4.81312959
36macromolecular complex remodeling (GO:0034367)4.81312959
37negative regulation of fibrinolysis (GO:0051918)4.80057474
38cholesterol efflux (GO:0033344)4.79293842
39oxidative demethylation (GO:0070989)4.77127175
40response to methylmercury (GO:0051597)4.68895949
41plasma lipoprotein particle assembly (GO:0034377)4.60125520
42protein activation cascade (GO:0072376)4.53195073
43cerebellar granule cell differentiation (GO:0021707)4.48838807
44plasma lipoprotein particle clearance (GO:0034381)4.29769616
45bile acid biosynthetic process (GO:0006699)4.28207504
46venous blood vessel morphogenesis (GO:0048845)4.25020864
47negative regulation of hemostasis (GO:1900047)4.17166184
48negative regulation of blood coagulation (GO:0030195)4.17166184
49alkaloid metabolic process (GO:0009820)4.02988368
50regulation of lipoprotein metabolic process (GO:0050746)3.95216650
51regulation of humoral immune response (GO:0002920)3.94778751
52protein-lipid complex assembly (GO:0065005)3.94430301
53lymphangiogenesis (GO:0001946)3.93884220
54negative regulation of norepinephrine secretion (GO:0010700)3.91955586
55cellular glucuronidation (GO:0052695)3.89469422
56pyrimidine nucleobase catabolic process (GO:0006208)3.88937021
57bile acid metabolic process (GO:0008206)3.86021640
58negative regulation of coagulation (GO:0050819)3.85284091
59alpha-linolenic acid metabolic process (GO:0036109)3.82081459
60epoxygenase P450 pathway (GO:0019373)3.80932973
61bile acid and bile salt transport (GO:0015721)3.78745355
62negative regulation of protein activation cascade (GO:2000258)3.77421306
63arginine metabolic process (GO:0006525)3.71182493
64nucleobase catabolic process (GO:0046113)3.69637469
65negative regulation of wound healing (GO:0061045)3.68748753
66complement activation (GO:0006956)3.65913357
67plasma lipoprotein particle organization (GO:0071827)3.62358757
68positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.54898621
69glucuronate metabolic process (GO:0019585)3.54561419
70uronic acid metabolic process (GO:0006063)3.54561419
71negative regulation of complement activation (GO:0045916)3.53493225
72positive regulation of renal sodium excretion (GO:0035815)3.52891388
73glyoxylate metabolic process (GO:0046487)3.45562914
74mRNA modification (GO:0016556)3.44011663
75negative regulation of lipid transport (GO:0032369)3.39711507
76negative regulation of lipase activity (GO:0060192)3.35231619
77exogenous drug catabolic process (GO:0042738)3.34353414
78diacylglycerol metabolic process (GO:0046339)3.33296826
79protein-lipid complex subunit organization (GO:0071825)3.32450260
80drug metabolic process (GO:0017144)3.31782270
81N-acetylneuraminate metabolic process (GO:0006054)3.30383308
82regulation of sterol transport (GO:0032371)3.28756333
83regulation of cholesterol transport (GO:0032374)3.28756333
84response to pheromone (GO:0019236)3.27905373
85response to manganese ion (GO:0010042)3.27784610
86regulation of apoptotic cell clearance (GO:2000425)3.26214594
87glycine metabolic process (GO:0006544)3.23359353
88neuronal stem cell maintenance (GO:0097150)3.21874265
89response to vitamin E (GO:0033197)3.19103922
90amino-acid betaine transport (GO:0015838)3.18194938
91carnitine transport (GO:0015879)3.18194938
92positive regulation of glycolytic process (GO:0045821)3.16502961
93regulation of response to tumor cell (GO:0002834)3.11098101
94positive regulation of response to tumor cell (GO:0002836)3.11098101
95positive regulation of immune response to tumor cell (GO:0002839)3.11098101
96regulation of immune response to tumor cell (GO:0002837)3.11098101
97serine family amino acid metabolic process (GO:0009069)3.10820475
98regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.06158818
99leukocyte migration involved in inflammatory response (GO:0002523)3.06062463
100heme transport (GO:0015886)3.06056100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse3.82210204
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.78781262
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.17145801
4TAF15_26573619_Chip-Seq_HEK293_Human3.10712246
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.08404852
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.97220048
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.96811655
8NFE2_27457419_Chip-Seq_LIVER_Mouse2.75606023
9TCF4_18268006_ChIP-ChIP_LS174T_Human2.57929963
10SUZ12_27294783_Chip-Seq_NPCs_Mouse2.47940203
11GBX2_23144817_ChIP-Seq_PC3_Human2.47743515
12GATA1_22025678_ChIP-Seq_K562_Human2.40021076
13EZH2_27294783_Chip-Seq_NPCs_Mouse2.35580488
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31088611
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.20444629
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.16237936
17CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse2.07096833
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.07033217
19P53_22387025_ChIP-Seq_ESCs_Mouse1.92105844
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88659121
21E2F1_18555785_Chip-Seq_ESCs_Mouse1.87829112
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84846279
23TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.84094787
24NANOG_18555785_Chip-Seq_ESCs_Mouse1.83836787
25CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.78252936
26SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.78111336
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.77766789
28HNFA_21074721_ChIP-Seq_CACO-2_Human1.76867676
29CMYC_18555785_Chip-Seq_ESCs_Mouse1.76406915
30GATA6_21074721_ChIP-Seq_CACO-2_Human1.75007072
31* NFYA_21822215_ChIP-Seq_K562_Human1.74443373
32FOXA2_19822575_ChIP-Seq_HepG2_Human1.73584035
33PHF8_20622853_ChIP-Seq_HELA_Human1.73312998
34OCT4_18555785_Chip-Seq_ESCs_Mouse1.72170435
35EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.71563166
36CBX2_22325352_ChIP-Seq_293T-Rex_Human1.70815114
37STAT3_18555785_Chip-Seq_ESCs_Mouse1.69766231
38ETV1_20927104_ChIP-Seq_GIST48_Human1.69272807
39RBPJ_21746931_ChIP-Seq_IB4_Human1.66589915
40OCT4_21477851_ChIP-Seq_ESCs_Mouse1.66169542
41P300_18555785_Chip-Seq_ESCs_Mouse1.65206440
42KLF4_18555785_Chip-Seq_ESCs_Mouse1.64943705
43GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.64097564
44SOX2_18555785_Chip-Seq_ESCs_Mouse1.64086870
45RUNX1_27457419_Chip-Seq_LIVER_Mouse1.62270451
46CRX_20693478_ChIP-Seq_RETINA_Mouse1.60300008
47SUZ12_18555785_Chip-Seq_ESCs_Mouse1.60091435
48SMAD1_18555785_Chip-Seq_ESCs_Mouse1.59827533
49* PIAS1_25552417_ChIP-Seq_VCAP_Human1.58596879
50CTCF_18555785_Chip-Seq_ESCs_Mouse1.57043605
51ER_23166858_ChIP-Seq_MCF-7_Human1.55828659
52* NFYB_21822215_ChIP-Seq_K562_Human1.55533485
53ZFX_18555785_Chip-Seq_ESCs_Mouse1.53914731
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53512778
55EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.53171380
56PU1_27457419_Chip-Seq_LIVER_Mouse1.52758977
57NMYC_18555785_Chip-Seq_ESCs_Mouse1.52263517
58ESRRB_18555785_Chip-Seq_ESCs_Mouse1.50751052
59* TBL1_22424771_ChIP-Seq_293T_Human1.49317090
60RNF2_27304074_Chip-Seq_NSC_Mouse1.48637299
61EZH2_22144423_ChIP-Seq_EOC_Human1.46390267
62TP53_16413492_ChIP-PET_HCT116_Human1.46230931
63PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.44061350
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40629996
65VDR_22108803_ChIP-Seq_LS180_Human1.38351284
66SMAD4_21799915_ChIP-Seq_A2780_Human1.37010730
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36159315
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32746838
69HTT_18923047_ChIP-ChIP_STHdh_Human1.30876948
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30702448
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28326709
72AR_21572438_ChIP-Seq_LNCaP_Human1.27942441
73BCAT_22108803_ChIP-Seq_LS180_Human1.25851587
74IGF1R_20145208_ChIP-Seq_DFB_Human1.25149371
75* HNF4A_19822575_ChIP-Seq_HepG2_Human1.22718115
76CBP_20019798_ChIP-Seq_JUKART_Human1.22647586
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22647586
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22208911
79* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21218660
80* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20033536
81IRF1_19129219_ChIP-ChIP_H3396_Human1.17225766
82TCF4_23295773_ChIP-Seq_U87_Human1.16592817
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15888067
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13481503
85STAT3_23295773_ChIP-Seq_U87_Human1.12150326
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10799574
87GATA4_25053715_ChIP-Seq_YYC3_Human1.09616244
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09106676
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08476891
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08298578
91* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07127712
92* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04504130
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03502958
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01229614
95* P300_19829295_ChIP-Seq_ESCs_Human1.00841381
96SOX2_21211035_ChIP-Seq_LN229_Gbm0.96627825
97FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95445559
98CBX2_27304074_Chip-Seq_ESCs_Mouse0.93216031
99PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90789223
100FLI1_21867929_ChIP-Seq_TH2_Mouse0.90677249

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system9.61284678
2MP0003195_calcinosis6.99143564
3MP0002139_abnormal_hepatobiliary_system5.03915592
4MP0010368_abnormal_lymphatic_system4.84370998
5MP0005085_abnormal_gallbladder_physiolo4.62089884
6MP0000569_abnormal_digit_pigmentation3.76758843
7MP0005365_abnormal_bile_salt3.47922043
8MP0003252_abnormal_bile_duct3.41931598
9MP0010329_abnormal_lipoprotein_level2.87591444
10MP0002876_abnormal_thyroid_physiology2.49518598
11MP0001666_abnormal_nutrient_absorption2.22286296
12MP0005645_abnormal_hypothalamus_physiol2.19912699
13MP0001661_extended_life_span2.13804400
14MP0003868_abnormal_feces_composition2.06833972
15MP0003880_abnormal_central_pattern1.68684303
16MP0000604_amyloidosis1.68074545
17MP0001879_abnormal_lymphatic_vessel1.65084418
18MP0008057_abnormal_DNA_replication1.63990416
19MP0004742_abnormal_vestibular_system1.56921464
20MP0002118_abnormal_lipid_homeostasis1.49998223
21MP0006276_abnormal_autonomic_nervous1.46526151
22MP0005464_abnormal_platelet_physiology1.44128065
23MP0005332_abnormal_amino_acid1.41582754
24MP0002928_abnormal_bile_duct1.34185109
25MP0003879_abnormal_hair_cell1.31803414
26MP0003690_abnormal_glial_cell1.28001612
27MP0005187_abnormal_penis_morphology1.26434720
28MP0005379_endocrine/exocrine_gland_phen1.20848543
29MP0005451_abnormal_body_composition1.17859850
30MP0005164_abnormal_response_to1.17223999
31MP0003943_abnormal_hepatobiliary_system1.17041211
32MP0005408_hypopigmentation1.16878825
33MP0002254_reproductive_system_inflammat1.12431558
34MP0004883_abnormal_blood_vessel1.11933866
35MP0000609_abnormal_liver_physiology1.10367780
36MP0005360_urolithiasis1.09329024
37MP0003122_maternal_imprinting1.08877075
38MP0001486_abnormal_startle_reflex1.08687087
39MP0005220_abnormal_exocrine_pancreas1.07734014
40MP0000383_abnormal_hair_follicle1.05932294
41MP0000003_abnormal_adipose_tissue1.03514750
42MP0003890_abnormal_embryonic-extraembry1.02378256
43MP0009115_abnormal_fat_cell0.99999394
44MP0003632_abnormal_nervous_system0.98415212
45MP0001764_abnormal_homeostasis0.96473243
46MP0005646_abnormal_pituitary_gland0.94357199
47MP0002078_abnormal_glucose_homeostasis0.93971483
48MP0005386_behavior/neurological_phenoty0.92522704
49MP0004924_abnormal_behavior0.92522704
50MP0003638_abnormal_response/metabolism_0.89149368
51MP0004019_abnormal_vitamin_homeostasis0.86184674
52MP0004130_abnormal_muscle_cell0.85601784
53MP0002168_other_aberrant_phenotype0.85327263
54MP0005376_homeostasis/metabolism_phenot0.84580278
55MP0003953_abnormal_hormone_level0.80871561
56MP0003959_abnormal_lean_body0.80017588
57MP0003011_delayed_dark_adaptation0.79642794
58MP0001915_intracranial_hemorrhage0.79534378
59MP0000598_abnormal_liver_morphology0.77932579
60MP0004272_abnormal_basement_membrane0.77186484
61MP0009642_abnormal_blood_homeostasis0.76288615
62MP0001944_abnormal_pancreas_morphology0.74430464
63MP0001501_abnormal_sleep_pattern0.74355994
64MP0003950_abnormal_plasma_membrane0.73751844
65MP0005319_abnormal_enzyme/_coenzyme0.68897742
66MP0002098_abnormal_vibrissa_morphology0.67811798
67MP0005334_abnormal_fat_pad0.67717973
68MP0003646_muscle_fatigue0.66981685
69MP0003878_abnormal_ear_physiology0.66331162
70MP0005377_hearing/vestibular/ear_phenot0.66331162
71MP0008469_abnormal_protein_level0.65038082
72MP0001346_abnormal_lacrimal_gland0.63365677
73MP0005395_other_phenotype0.63091132
74MP0005535_abnormal_body_temperature0.62879692
75MP0003631_nervous_system_phenotype0.61768105
76MP0002971_abnormal_brown_adipose0.60998735
77MP0005647_abnormal_sex_gland0.60519254
78MP0003633_abnormal_nervous_system0.59483690
79MP0005551_abnormal_eye_electrophysiolog0.59335048
80MP0005636_abnormal_mineral_homeostasis0.59125587
81MP0008875_abnormal_xenobiotic_pharmacok0.58511506
82MP0005076_abnormal_cell_differentiation0.58324652
83MP0004147_increased_porphyrin_level0.56489993
84MP0000647_abnormal_sebaceous_gland0.55217985
85MP0005375_adipose_tissue_phenotype0.54493185
86MP0005670_abnormal_white_adipose0.54190470
87MP0003123_paternal_imprinting0.54056603
88MP0000920_abnormal_myelination0.53439890
89MP0005083_abnormal_biliary_tract0.53231039
90MP0008004_abnormal_stomach_pH0.51887255
91MP0002229_neurodegeneration0.51213920
92MP0008770_decreased_survivor_rate0.51083319
93MP0002909_abnormal_adrenal_gland0.50370835
94MP0000249_abnormal_blood_vessel0.49838826
95MP0002733_abnormal_thermal_nociception0.47278767
96MP0005084_abnormal_gallbladder_morpholo0.46630836
97MP0002067_abnormal_sensory_capabilities0.46460293
98MP0001324_abnormal_eye_pigmentation0.45677321
99MP0005389_reproductive_system_phenotype0.44864890
100MP0001919_abnormal_reproductive_system0.44372452

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)9.79397786
2Abnormality of monocarboxylic acid metabolism (HP:0010996)9.45880304
3Osteomalacia (HP:0002749)8.06872633
4Complement deficiency (HP:0004431)7.08068840
5Abnormality of pyrimidine metabolism (HP:0004353)6.03947477
6Generalized aminoaciduria (HP:0002909)5.83586914
7Glomerulonephritis (HP:0000099)5.60396309
8Abnormality of complement system (HP:0005339)5.19325547
9Abnormality of the common coagulation pathway (HP:0010990)4.72767123
10Joint hemorrhage (HP:0005261)4.68219924
11Intrahepatic cholestasis (HP:0001406)4.52323138
12Menorrhagia (HP:0000132)4.24041677
13Fat malabsorption (HP:0002630)4.22815743
14Rickets (HP:0002748)3.95473557
15Steatorrhea (HP:0002570)3.84709969
16Abnormality of nucleobase metabolism (HP:0010932)3.80520157
17Scanning speech (HP:0002168)3.77650724
18Hyperphosphaturia (HP:0003109)3.56675254
19Arthropathy (HP:0003040)3.53532096
20Abnormality of vitamin metabolism (HP:0100508)3.43302623
21Conjugated hyperbilirubinemia (HP:0002908)3.37929343
22Acanthocytosis (HP:0001927)3.33911535
23Hypobetalipoproteinemia (HP:0003563)3.32906318
24Wrist flexion contracture (HP:0001239)3.29448547
25Hypophosphatemic rickets (HP:0004912)3.16733458
26Peritonitis (HP:0002586)3.10856460
27Systemic lupus erythematosus (HP:0002725)3.06939264
28Nephritis (HP:0000123)3.05810774
29Xanthomatosis (HP:0000991)3.00004906
30Decreased subcutaneous fat (HP:0001002)2.97454823
31Abnormal urine phosphate concentration (HP:0012599)2.95963253
32Sensorimotor neuropathy (HP:0007141)2.94502385
33Vascular calcification (HP:0004934)2.92159744
34Papillary thyroid carcinoma (HP:0002895)2.90298477
35Abnormality of the intrinsic pathway (HP:0010989)2.88101141
36Abnormality of purine metabolism (HP:0004352)2.78115969
37Hypercholesterolemia (HP:0003124)2.72195724
38Hypophosphatemia (HP:0002148)2.63482103
39Glycosuria (HP:0003076)2.61151532
40Abnormality of urine glucose concentration (HP:0011016)2.61151532
41Cardiovascular calcification (HP:0011915)2.53391043
42Bile duct proliferation (HP:0001408)2.48171024
43Abnormal biliary tract physiology (HP:0012439)2.48171024
44Gonadotropin excess (HP:0000837)2.46961781
45Toxemia of pregnancy (HP:0100603)2.39678144
46Gastrointestinal infarctions (HP:0005244)2.37417201
47Macroorchidism (HP:0000053)2.33903286
48Cholecystitis (HP:0001082)2.32623515
49Abnormal gallbladder physiology (HP:0012438)2.32623515
50Elevated alkaline phosphatase (HP:0003155)2.31613681
51Prolonged bleeding time (HP:0003010)2.30491294
52Renal tubular dysfunction (HP:0000124)2.29386773
53Myocardial infarction (HP:0001658)2.21720578
54Hypokalemia (HP:0002900)2.15227036
55Poikilocytosis (HP:0004447)2.13785629
56Hyperammonemia (HP:0001987)2.11363484
57Hypoplastic labia majora (HP:0000059)2.08608864
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.07211279
59Abnormality of alkaline phosphatase activity (HP:0004379)2.05856916
60Abnormality of transition element cation homeostasis (HP:0011030)2.04223166
61Postural instability (HP:0002172)2.04116242
62Hypolipoproteinemia (HP:0010981)2.01760921
63Spontaneous abortion (HP:0005268)2.01452421
64Deep venous thrombosis (HP:0002625)11.7185265
65Hepatoblastoma (HP:0002884)1.98343907
66Increased serum ferritin (HP:0003281)1.97882248
67Abnormal enzyme/coenzyme activity (HP:0012379)1.96621510
68Purpura (HP:0000979)1.95780754
69Truncal obesity (HP:0001956)1.90360625
70Abnormality of subcutaneous fat tissue (HP:0001001)1.88892818
71Abnormality of the labia majora (HP:0012881)1.87804658
72Abnormality of iron homeostasis (HP:0011031)1.84672148
73Polycythemia (HP:0001901)1.84489991
74Epistaxis (HP:0000421)1.84322039
75Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.83063613
76Gingival bleeding (HP:0000225)1.82688903
77Acute hepatic failure (HP:0006554)1.80158117
78Epidermoid cyst (HP:0200040)1.79774862
79Enlarged kidneys (HP:0000105)1.79004635
80Hepatocellular carcinoma (HP:0001402)1.78453405
81Abnormality of potassium homeostasis (HP:0011042)1.78104663
82Chin dimple (HP:0010751)1.75682729
83Congenital sensorineural hearing impairment (HP:0008527)1.75499252
84Cortical dysplasia (HP:0002539)1.74836975
85Increased mean platelet volume (HP:0011877)1.70227200
86Esophageal varix (HP:0002040)1.67307785
87Hyperinsulinemic hypoglycemia (HP:0000825)1.66028136
88Increased neuronal autofluorescent lipopigment (HP:0002074)1.65068835
89Anorexia (HP:0002039)1.61764344
90Abdominal distention (HP:0003270)1.61088055
91Genetic anticipation (HP:0003743)1.57847977
92Thyroid carcinoma (HP:0002890)1.56514113
93Hyperglycinemia (HP:0002154)1.55976505
94Late onset (HP:0003584)1.55084984
95Decreased muscle mass (HP:0003199)1.53989934
96Thoracolumbar scoliosis (HP:0002944)1.53421567
97Delayed puberty (HP:0000823)1.50869697
98Bifid scrotum (HP:0000048)1.50157115
99Spastic paraparesis (HP:0002313)1.49125499
100Progressive visual loss (HP:0000529)1.46997422

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK7.30649246
2FRK5.20368655
3TAOK34.18101404
4TAOK13.27243382
5CAMK1G3.02534751
6PNCK2.95870726
7PIK3CA2.55981155
8LATS12.44037568
9WNK32.29841744
10CAMK1D2.14167277
11ACVR1B2.11306646
12FGFR21.94187508
13GRK11.92752942
14MAP4K21.79958228
15BMPR1B1.72941050
16MAP3K21.39393372
17NEK61.34711114
18NEK91.25453363
19PRKCG1.20632375
20INSRR1.19475192
21SIK21.18138927
22PLK41.11828553
23MUSK1.11179335
24WNK11.04816804
25MAPK131.04362799
26PRKACG0.96340708
27STK110.95609231
28STK38L0.91324359
29PRKAA10.87648608
30NTRK20.86126743
31TIE10.85864535
32JAK20.85767683
33PRKAA20.81768515
34SGK20.80044585
35WNK40.79458880
36ADRBK20.79456242
37RIPK10.78325481
38PRKG10.77971057
39YES10.76372994
40LATS20.76227963
41AKT30.75091045
42TGFBR10.74110051
43NTRK30.71798411
44CDK120.70134710
45SGK10.69895793
46MARK10.68987433
47NTRK10.64502343
48STK390.63376378
49STK380.61619267
50PIK3CG0.61275119
51PAK30.60856183
52IGF1R0.59097890
53MAP2K10.58034896
54SGK4940.57631036
55SGK2230.57631036
56CSNK1E0.57002070
57PRKCB0.56506095
58SYK0.56097161
59CSNK1D0.54552573
60PKN10.52665113
61BCR0.51541399
62RPS6KB10.51419417
63BMPR20.50784403
64PRKACB0.50103499
65MAP3K40.49536395
66MST40.47569496
67OXSR10.47211599
68MAPK10.45521294
69FGFR10.44149346
70ADRBK10.44029978
71RPS6KA30.43039564
72FYN0.42861778
73SGK30.42533134
74CAMK2G0.42287145
75PDGFRB0.41516935
76NLK0.41239195
77PRKACA0.41005640
78CSNK1A10.40980959
79CAMK2B0.39712825
80PRKCE0.38393855
81PRKCA0.38082492
82CAMK10.37917451
83MYLK0.36291137
84FGFR30.35838051
85CASK0.34679371
86RPS6KA50.34524040
87PRKCZ0.34249610
88PRKCI0.33932518
89MAPK140.33900069
90ZAP700.33812851
91MAPK30.33202591
92MAPK110.32937782
93MET0.32692660
94DAPK20.32582560
95FLT30.32191864
96IRAK40.31728522
97MAP3K70.30658084
98ERBB40.30268136
99DYRK20.29498851
100ABL10.29216629

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.82189603
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.18842892
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.86010450
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.67968195
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.18004107
6Pantothenate and CoA biosynthesis_Homo sapiens_hsa007703.15828208
7Steroid hormone biosynthesis_Homo sapiens_hsa001403.13621962
8Retinol metabolism_Homo sapiens_hsa008303.06038421
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.87907297
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.83782609
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.78561310
12Chemical carcinogenesis_Homo sapiens_hsa052042.75420665
13Histidine metabolism_Homo sapiens_hsa003402.59420720
14Arginine biosynthesis_Homo sapiens_hsa002202.44834333
15Drug metabolism - other enzymes_Homo sapiens_hsa009832.12447035
16Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.10784087
17Starch and sucrose metabolism_Homo sapiens_hsa005002.05170154
18Butanoate metabolism_Homo sapiens_hsa006501.96627624
19Staphylococcus aureus infection_Homo sapiens_hsa051501.95382431
20Bile secretion_Homo sapiens_hsa049761.86957565
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85869650
22Fatty acid biosynthesis_Homo sapiens_hsa000611.81576944
23ABC transporters_Homo sapiens_hsa020101.77276618
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.66574308
25Selenocompound metabolism_Homo sapiens_hsa004501.40453645
26TGF-beta signaling pathway_Homo sapiens_hsa043501.34118898
27Linoleic acid metabolism_Homo sapiens_hsa005911.32415804
28beta-Alanine metabolism_Homo sapiens_hsa004101.29906732
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27687175
30Peroxisome_Homo sapiens_hsa041461.21920046
31Nitrogen metabolism_Homo sapiens_hsa009101.21203394
32Circadian rhythm_Homo sapiens_hsa047101.16130872
33Fatty acid metabolism_Homo sapiens_hsa012121.11438558
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06534920
35Tryptophan metabolism_Homo sapiens_hsa003801.05444748
36Fat digestion and absorption_Homo sapiens_hsa049751.05201784
37Dorso-ventral axis formation_Homo sapiens_hsa043201.01327487
38PPAR signaling pathway_Homo sapiens_hsa033201.00177676
39Type II diabetes mellitus_Homo sapiens_hsa049300.98993969
40Fatty acid degradation_Homo sapiens_hsa000710.92337195
41Glucagon signaling pathway_Homo sapiens_hsa049220.91046651
42Arginine and proline metabolism_Homo sapiens_hsa003300.88680362
43Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85652089
44Fatty acid elongation_Homo sapiens_hsa000620.80132189
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75300288
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71042560
47Arachidonic acid metabolism_Homo sapiens_hsa005900.70199336
48Insulin resistance_Homo sapiens_hsa049310.68808456
49Phenylalanine metabolism_Homo sapiens_hsa003600.67298735
50Glycerolipid metabolism_Homo sapiens_hsa005610.65204112
51Nicotine addiction_Homo sapiens_hsa050330.60495493
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.57858163
53Prion diseases_Homo sapiens_hsa050200.54120354
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52111631
55Vitamin digestion and absorption_Homo sapiens_hsa049770.47885108
56Insulin secretion_Homo sapiens_hsa049110.44888913
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44488953
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44331175
59Pertussis_Homo sapiens_hsa051330.44188650
60Serotonergic synapse_Homo sapiens_hsa047260.42368003
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.39367721
62Prolactin signaling pathway_Homo sapiens_hsa049170.31941017
63Sulfur metabolism_Homo sapiens_hsa009200.31811444
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28473317
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27977472
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27459710
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.25657478
68Metabolic pathways_Homo sapiens_hsa011000.25321899
69Propanoate metabolism_Homo sapiens_hsa006400.24953336
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24908114
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21603750
72Long-term depression_Homo sapiens_hsa047300.19822712
73Lysine degradation_Homo sapiens_hsa003100.17073527
74Systemic lupus erythematosus_Homo sapiens_hsa053220.16476486
75Mineral absorption_Homo sapiens_hsa049780.16389164
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.15856944
77AMPK signaling pathway_Homo sapiens_hsa041520.14700047
78Glutamatergic synapse_Homo sapiens_hsa047240.13321595
79Collecting duct acid secretion_Homo sapiens_hsa049660.13203786
80Insulin signaling pathway_Homo sapiens_hsa049100.10755617
81GABAergic synapse_Homo sapiens_hsa047270.10689636
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.10468892
83Galactose metabolism_Homo sapiens_hsa000520.09685059
84Ether lipid metabolism_Homo sapiens_hsa005650.09156276
85Biosynthesis of amino acids_Homo sapiens_hsa012300.07331208
86Synaptic vesicle cycle_Homo sapiens_hsa047210.07247320
87Fructose and mannose metabolism_Homo sapiens_hsa000510.07070279
88Pancreatic secretion_Homo sapiens_hsa049720.06846195
89Sphingolipid metabolism_Homo sapiens_hsa006000.05276405
90* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.04607525
91Cocaine addiction_Homo sapiens_hsa050300.03587575
92ECM-receptor interaction_Homo sapiens_hsa045120.03284098
93Amoebiasis_Homo sapiens_hsa051460.02734378
94Tyrosine metabolism_Homo sapiens_hsa003500.02182417
95Phototransduction_Homo sapiens_hsa047440.02126402
96Vibrio cholerae infection_Homo sapiens_hsa051100.01370987
97Platelet activation_Homo sapiens_hsa046110.00425959
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.00390355
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.00035440
100Cysteine and methionine metabolism_Homo sapiens_hsa00270-0.0174374

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