MTPAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)6.39910980
2sperm motility (GO:0030317)4.55122349
3rRNA methylation (GO:0031167)4.55095588
4DNA double-strand break processing (GO:0000729)4.47232122
5DNA strand elongation involved in DNA replication (GO:0006271)4.21567776
6single strand break repair (GO:0000012)4.20619514
7DNA replication initiation (GO:0006270)4.15260598
8acrosome reaction (GO:0007340)4.15141889
9nucleobase biosynthetic process (GO:0046112)4.10472295
10telomere maintenance via semi-conservative replication (GO:0032201)4.04031218
11DNA strand elongation (GO:0022616)4.01674898
12maturation of SSU-rRNA (GO:0030490)4.01066441
13ribosomal small subunit assembly (GO:0000028)4.00008815
14mitotic metaphase plate congression (GO:0007080)3.93928375
15centriole replication (GO:0007099)3.93190124
16DNA replication checkpoint (GO:0000076)3.91724593
17protein polyglutamylation (GO:0018095)3.90184395
18negative regulation of DNA-dependent DNA replication (GO:2000104)3.80085209
19microtubule depolymerization (GO:0007019)3.76409676
20meiotic chromosome segregation (GO:0045132)3.75266959
21DNA deamination (GO:0045006)3.73737108
22CENP-A containing nucleosome assembly (GO:0034080)3.72911755
23metaphase plate congression (GO:0051310)3.69904693
24purine nucleobase biosynthetic process (GO:0009113)3.67401326
25respiratory chain complex IV assembly (GO:0008535)3.66541279
26sperm-egg recognition (GO:0035036)3.65500217
27replication fork processing (GO:0031297)3.64323201
28chromatin remodeling at centromere (GO:0031055)3.58922916
29telomere maintenance via recombination (GO:0000722)3.57956596
30DNA unwinding involved in DNA replication (GO:0006268)3.57608487
31attachment of spindle microtubules to kinetochore (GO:0008608)3.56769987
32protein localization to kinetochore (GO:0034501)3.51062210
33spermatid development (GO:0007286)3.49299061
34purine ribonucleotide transport (GO:0015868)3.47755280
35formation of translation preinitiation complex (GO:0001731)3.46530889
36protein deneddylation (GO:0000338)3.46189227
37mismatch repair (GO:0006298)3.40553424
38regulation of mitotic spindle checkpoint (GO:1903504)3.36877824
39regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.36877824
40somatic diversification of immune receptors via somatic mutation (GO:0002566)3.35492481
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.35492481
42adenine nucleotide transport (GO:0051503)3.35246810
43spermatid nucleus differentiation (GO:0007289)3.35140098
44establishment of chromosome localization (GO:0051303)3.32257166
45mitotic recombination (GO:0006312)3.30912445
46microtubule polymerization or depolymerization (GO:0031109)3.30593470
47nucleotide-excision repair, DNA gap filling (GO:0006297)3.29355415
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.27785917
49DNA replication-independent nucleosome organization (GO:0034724)3.27746848
50DNA replication-independent nucleosome assembly (GO:0006336)3.27746848
51regulation of cilium movement (GO:0003352)3.26450987
52telomere maintenance via telomere lengthening (GO:0010833)3.25410388
53proteasome assembly (GO:0043248)3.24483876
54cullin deneddylation (GO:0010388)3.23710980
55cytochrome complex assembly (GO:0017004)3.23059734
56regulation of nuclear cell cycle DNA replication (GO:0033262)3.22588937
57binding of sperm to zona pellucida (GO:0007339)3.20862435
58ribosome biogenesis (GO:0042254)3.19691621
59postreplication repair (GO:0006301)3.19614382
60recombinational repair (GO:0000725)3.15644482
61negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.15091331
62multicellular organism reproduction (GO:0032504)3.14251458
63fusion of sperm to egg plasma membrane (GO:0007342)3.13924515
64regulation of meiosis I (GO:0060631)3.13292362
65double-strand break repair via homologous recombination (GO:0000724)3.12532684
66epithelial cilium movement (GO:0003351)3.09872220
67regulation of helicase activity (GO:0051095)3.08718950
68translesion synthesis (GO:0019985)3.07340357
69regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06973647
70synapsis (GO:0007129)3.05990524
71mitotic chromosome condensation (GO:0007076)3.05566089
72negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.05356230
73negative regulation of sister chromatid segregation (GO:0033046)3.05356230
74negative regulation of mitotic sister chromatid separation (GO:2000816)3.05356230
75negative regulation of mitotic sister chromatid segregation (GO:0033048)3.05356230
76mitotic spindle assembly checkpoint (GO:0007094)3.04955114
77spindle assembly checkpoint (GO:0071173)3.04950431
78IMP biosynthetic process (GO:0006188)3.04076615
79negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.03679909
80negative regulation of telomerase activity (GO:0051974)3.02961851
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01707315
82regulation of centriole replication (GO:0046599)3.00764597
83maturation of 5.8S rRNA (GO:0000460)3.00410558
84ribosome assembly (GO:0042255)2.99573473
85negative regulation of chromosome segregation (GO:0051985)2.97739311
86histone H2A acetylation (GO:0043968)2.97013562
87positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95947575
88somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.95459630
89isotype switching (GO:0045190)2.95459630
90somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.95459630
91regulation of centrosome cycle (GO:0046605)2.93696634
92mitotic nuclear envelope disassembly (GO:0007077)2.93309042
93cellular ketone body metabolic process (GO:0046950)2.92650454
94rRNA modification (GO:0000154)2.92220866
95ribosomal large subunit biogenesis (GO:0042273)2.91252960
96ribonucleoprotein complex biogenesis (GO:0022613)2.90020377
97rRNA processing (GO:0006364)2.89901377
98spindle checkpoint (GO:0031577)2.88348582
99cell-cell recognition (GO:0009988)2.87590976
100piRNA metabolic process (GO:0034587)2.87405938
101histone exchange (GO:0043486)2.87281861
102nuclear pore organization (GO:0006999)2.86850221
103IMP metabolic process (GO:0046040)2.86028940
104DNA replication-dependent nucleosome organization (GO:0034723)2.83990092
105DNA replication-dependent nucleosome assembly (GO:0006335)2.83990092
106mitotic spindle checkpoint (GO:0071174)2.83618879
107viral mRNA export from host cell nucleus (GO:0046784)2.83616717
108intra-S DNA damage checkpoint (GO:0031573)2.82978004
109L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82782250
110deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.82531613
111protein K6-linked ubiquitination (GO:0085020)2.82363676
112termination of RNA polymerase III transcription (GO:0006386)2.81652946
113transcription elongation from RNA polymerase III promoter (GO:0006385)2.81652946
114protein localization to chromosome, centromeric region (GO:0071459)2.80961918
115negative regulation of transcription regulatory region DNA binding (GO:2000678)2.80758996
116kinetochore organization (GO:0051383)2.79926618
117nodal signaling pathway (GO:0038092)2.79175538
118RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.78152507
119tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.77532181
120RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.77532181
121rRNA metabolic process (GO:0016072)2.77265934
122fucose catabolic process (GO:0019317)2.76915550
123L-fucose metabolic process (GO:0042354)2.76915550
124L-fucose catabolic process (GO:0042355)2.76915550
125water-soluble vitamin biosynthetic process (GO:0042364)2.76342125
126maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.76127377
127centriole assembly (GO:0098534)2.75673555
128folic acid-containing compound biosynthetic process (GO:0009396)2.75398638
129DNA catabolic process, exonucleolytic (GO:0000738)2.74997845
130negative regulation of ligase activity (GO:0051352)2.74641495
131negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.74641495
132regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.74398617
133mitotic sister chromatid segregation (GO:0000070)2.74013152
134spliceosomal complex assembly (GO:0000245)2.73709193
135telomere maintenance (GO:0000723)2.71183874
136DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.71059099
137cell cycle G1/S phase transition (GO:0044843)2.70661305
138G1/S transition of mitotic cell cycle (GO:0000082)2.70661305
139DNA packaging (GO:0006323)2.69592962
140telomere organization (GO:0032200)2.68189524
141intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.67219375
142signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.67219375
143regulation of telomere maintenance via telomerase (GO:0032210)2.67178627
144deoxyribonucleotide biosynthetic process (GO:0009263)2.66540758
145peptidyl-histidine modification (GO:0018202)2.66374795
146nonmotile primary cilium assembly (GO:0035058)2.64774621
147sperm capacitation (GO:0048240)2.64708853
148regulation of DNA endoreduplication (GO:0032875)2.64285587
149resolution of meiotic recombination intermediates (GO:0000712)2.63168079
150negative regulation of DNA recombination (GO:0045910)2.60856147
151mitochondrial respiratory chain complex assembly (GO:0033108)2.60349894
152retinal cone cell development (GO:0046549)2.59867341
153ketone body metabolic process (GO:1902224)2.59756488
154chromosome condensation (GO:0030261)2.59526043
155male gamete generation (GO:0048232)2.59395367
156spermatogenesis (GO:0007283)2.59154380
157negative regulation of translation, ncRNA-mediated (GO:0040033)2.56227988
158regulation of translation, ncRNA-mediated (GO:0045974)2.56227988
159negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.56227988
160DNA methylation involved in gamete generation (GO:0043046)2.55687446
161protein complex biogenesis (GO:0070271)2.55290041
162axonemal dynein complex assembly (GO:0070286)2.53356458
163negative regulation of telomere maintenance (GO:0032205)2.51169570
164plasma membrane fusion (GO:0045026)2.50944595
165exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.50437880
166nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.49839587
167regulation of glucokinase activity (GO:0033131)2.49827572
168regulation of hexokinase activity (GO:1903299)2.49827572
169cilium movement (GO:0003341)2.47703867
170establishment of protein localization to Golgi (GO:0072600)2.47685287
171cilium organization (GO:0044782)2.47414141
172regulation of centrosome duplication (GO:0010824)2.46498470
173gamete generation (GO:0007276)2.45706033
174protein targeting to Golgi (GO:0000042)2.45235112
175epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.44857245
176regulation of telomere maintenance (GO:0032204)2.44360466
177protein K11-linked deubiquitination (GO:0035871)2.44025256
178calcium ion-dependent exocytosis (GO:0017156)2.43328799
179protein-cofactor linkage (GO:0018065)2.42641504

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.23756421
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.84509938
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.81263631
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.58466063
5ZNF274_21170338_ChIP-Seq_K562_Hela3.53479814
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.45893394
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.32592084
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.24686529
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.14329868
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12837487
11VDR_22108803_ChIP-Seq_LS180_Human3.10206792
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.08016099
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03303303
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.82476050
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.81215911
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73269546
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65021484
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59611631
19FUS_26573619_Chip-Seq_HEK293_Human2.58944264
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55998588
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.52562337
22VDR_23849224_ChIP-Seq_CD4+_Human2.47186114
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44480501
24AR_21909140_ChIP-Seq_LNCAP_Human2.42891126
25TAF15_26573619_Chip-Seq_HEK293_Human2.36358674
26GBX2_23144817_ChIP-Seq_PC3_Human2.35259159
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.34180681
28POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30710545
29FOXP3_21729870_ChIP-Seq_TREG_Human2.28679735
30* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27474256
31* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.24690605
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16360708
33P300_19829295_ChIP-Seq_ESCs_Human2.15216606
34E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13561894
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13287659
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.13135028
37CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11076127
38ELK1_19687146_ChIP-ChIP_HELA_Human2.10727606
39ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08516385
40SRF_21415370_ChIP-Seq_HL-1_Mouse2.02563428
41THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00258574
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98330819
43DCP1A_22483619_ChIP-Seq_HELA_Human1.96723868
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96266082
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94585777
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.92315787
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91977817
48XRN2_22483619_ChIP-Seq_HELA_Human1.91302100
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.91052087
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90929614
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.87150751
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84961450
53TTF2_22483619_ChIP-Seq_HELA_Human1.83024399
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79377952
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79219302
56GABP_19822575_ChIP-Seq_HepG2_Human1.79066567
57ER_23166858_ChIP-Seq_MCF-7_Human1.78239874
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77149925
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72738338
60* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70185390
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69984354
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69699622
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68472230
64CBP_20019798_ChIP-Seq_JUKART_Human1.68472230
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62813435
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59196840
67* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59133865
68CIITA_25753668_ChIP-Seq_RAJI_Human1.56954726
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.56083250
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55679518
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54898311
72* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54865244
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54252232
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53385592
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.51547474
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49451896
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48624565
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.46190535
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43016726
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42828594
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41290910
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.40893481
83ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39929464
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39271973
85NANOG_19829295_ChIP-Seq_ESCs_Human1.38926654
86SOX2_19829295_ChIP-Seq_ESCs_Human1.38926654
87AR_25329375_ChIP-Seq_VCAP_Human1.38047454
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37683034
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37683034
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.37624186
91POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36964025
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.33955921
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30933936
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.30350696
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.29003857
96SMAD4_21799915_ChIP-Seq_A2780_Human1.28973233
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.28586368
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28392911
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.28161885
100BCAT_22108803_ChIP-Seq_LS180_Human1.28098492
101IRF8_21731497_ChIP-ChIP_J774_Mouse1.26990638
102STAT3_23295773_ChIP-Seq_U87_Human1.25952305
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24933139
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24513505
105CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23769003
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.23570497
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20683627
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19552838
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.19075581
110IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17480717
111IRF1_19129219_ChIP-ChIP_H3396_Human1.17225571
112KDM5A_27292631_Chip-Seq_BREAST_Human1.17063384
113TP53_22573176_ChIP-Seq_HFKS_Human1.16620707
114FOXA1_25329375_ChIP-Seq_VCAP_Human1.16512879
115FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16512879
116TCF4_22108803_ChIP-Seq_LS180_Human1.16424195
117MYC_18940864_ChIP-ChIP_HL60_Human1.16397001
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.15111478
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12389153
120RUNX2_22187159_ChIP-Seq_PCA_Human1.12002660
121AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11294757
122SPI1_23547873_ChIP-Seq_NB4_Human1.11084235
123EGR1_19374776_ChIP-ChIP_THP-1_Human1.10712579
124* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10052773
125HOXB7_26014856_ChIP-Seq_BT474_Human1.09436396
126FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09111225
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08811690
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07477828
129TCF4_23295773_ChIP-Seq_U87_Human1.07477484
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07167490
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06734802
132IGF1R_20145208_ChIP-Seq_DFB_Human1.05155094
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04775327
134IRF8_22096565_ChIP-ChIP_GC-B_Human1.04213143
135RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00899126
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00556472
137MYC_22102868_ChIP-Seq_BL_Human1.00549575
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00496289
139FLI1_27457419_Chip-Seq_LIVER_Mouse1.00046422
140P300_18555785_Chip-Seq_ESCs_Mouse0.98679544
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98117679
142E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97673027
143CDX2_22108803_ChIP-Seq_LS180_Human0.97653340
144P53_22387025_ChIP-Seq_ESCs_Mouse0.97370246
145RBPJ_21746931_ChIP-Seq_IB4_Human0.97304349
146EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97235697
147CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96704514
148NCOR_22424771_ChIP-Seq_293T_Human0.96409894
149* TFEB_21752829_ChIP-Seq_HELA_Human0.96116637
150* PHF8_20622853_ChIP-Seq_HELA_Human0.95824818
151STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92995394
152MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92368655
153CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90629465
154HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90547456
155POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88324466
156SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88272992
157FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.86179549
158BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85594509
159KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84415424
160EWS_26573619_Chip-Seq_HEK293_Human0.82780038
161* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.81321114
162CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80805173
163PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77011911
164HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.76923686
165FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76722819
166KLF4_18555785_ChIP-Seq_MESCs_Mouse0.75990577
167CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.74610407
168MYB_21317192_ChIP-Seq_ERMYB_Mouse0.74261861
169MYB_26560356_Chip-Seq_TH2_Human0.73994877

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.38485178
2MP0010094_abnormal_chromosome_stability4.50892763
3MP0008057_abnormal_DNA_replication3.95640084
4MP0008058_abnormal_DNA_repair3.81072233
5MP0005410_abnormal_fertilization3.72707561
6MP0003077_abnormal_cell_cycle3.71215607
7MP0004957_abnormal_blastocyst_morpholog3.66934550
8MP0002102_abnormal_ear_morphology3.28161697
9MP0003111_abnormal_nucleus_morphology3.20939029
10MP0002396_abnormal_hematopoietic_system3.02060873
11MP0008932_abnormal_embryonic_tissue2.51348234
12MP0008007_abnormal_cellular_replicative2.43154748
13MP0008877_abnormal_DNA_methylation2.33381694
14MP0000490_abnormal_crypts_of2.18974777
15MP0003123_paternal_imprinting2.14586089
16MP0001835_abnormal_antigen_presentation2.11598456
17MP0006072_abnormal_retinal_apoptosis2.07933827
18MP0002938_white_spotting2.05686524
19MP0003698_abnormal_male_reproductive1.96074159
20MP0003195_calcinosis1.94966943
21MP0004808_abnormal_hematopoietic_stem1.91459453
22MP0003763_abnormal_thymus_physiology1.90716166
23MP0005551_abnormal_eye_electrophysiolog1.89605355
24MP0003718_maternal_effect1.80909972
25MP0006292_abnormal_olfactory_placode1.78975274
26MP0005253_abnormal_eye_physiology1.78405704
27MP0000569_abnormal_digit_pigmentation1.73688090
28MP0003787_abnormal_imprinting1.70428789
29MP0005084_abnormal_gallbladder_morpholo1.66965092
30MP0005671_abnormal_response_to1.66512565
31MP0009697_abnormal_copulation1.66431046
32MP0003121_genomic_imprinting1.64343334
33MP0002398_abnormal_bone_marrow1.62001012
34MP0005367_renal/urinary_system_phenotyp1.58568919
35MP0000516_abnormal_urinary_system1.58568919
36MP0000350_abnormal_cell_proliferation1.55341691
37MP0005397_hematopoietic_system_phenotyp1.54960671
38MP0001545_abnormal_hematopoietic_system1.54960671
39MP0001529_abnormal_vocalization1.51760275
40MP0003880_abnormal_central_pattern1.50629325
41MP0003646_muscle_fatigue1.49694368
42MP0003806_abnormal_nucleotide_metabolis1.49666641
43MP0001800_abnormal_humoral_immune1.49374462
44MP0001853_heart_inflammation1.47735772
45MP0010386_abnormal_urinary_bladder1.47700912
46MP0003011_delayed_dark_adaptation1.47601592
47MP0003786_premature_aging1.47554260
48MP0002234_abnormal_pharynx_morphology1.45370958
49MP0001485_abnormal_pinna_reflex1.45035526
50MP0009785_altered_susceptibility_to1.43788175
51MP0002019_abnormal_tumor_incidence1.41504459
52MP0002736_abnormal_nociception_after1.39822016
53MP0000689_abnormal_spleen_morphology1.39656096
54MP0001968_abnormal_touch/_nociception1.37599186
55MP0001986_abnormal_taste_sensitivity1.37084842
56MP0009333_abnormal_splenocyte_physiolog1.36500280
57MP0000703_abnormal_thymus_morphology1.35457575
58MP0002837_dystrophic_cardiac_calcinosis1.34351550
59MP0002751_abnormal_autonomic_nervous1.33149632
60MP0000427_abnormal_hair_cycle1.31704872
61MP0000313_abnormal_cell_death1.31087151
62MP0002722_abnormal_immune_system1.30969324
63MP0001984_abnormal_olfaction1.28408115
64MP0008789_abnormal_olfactory_epithelium1.26868298
65MP0001486_abnormal_startle_reflex1.26383646
66MP0000716_abnormal_immune_system1.25665055
67MP0002429_abnormal_blood_cell1.25043935
68MP0008872_abnormal_physiological_respon1.24105643
69MP0009745_abnormal_behavioral_response1.23452637
70MP0003937_abnormal_limbs/digits/tail_de1.22255973
71MP0001819_abnormal_immune_cell1.21909928
72MP0002723_abnormal_immune_serum1.21168538
73MP0001730_embryonic_growth_arrest1.21119723
74MP0002420_abnormal_adaptive_immunity1.20782056
75MP0002452_abnormal_antigen_presenting1.20011930
76MP0005380_embryogenesis_phenotype1.19871388
77MP0001672_abnormal_embryogenesis/_devel1.19871388
78MP0009046_muscle_twitch1.19652687
79MP0003984_embryonic_growth_retardation1.19170949
80MP0004147_increased_porphyrin_level1.17931036
81MP0000685_abnormal_immune_system1.17461273
82MP0008995_early_reproductive_senescence1.15798181
83MP0000343_altered_response_to1.14280805
84MP0005379_endocrine/exocrine_gland_phen1.13508460
85MP0002088_abnormal_embryonic_growth/wei1.12318977
86MP0004133_heterotaxia1.11904032
87MP0005075_abnormal_melanosome_morpholog1.11389112
88MP0001697_abnormal_embryo_size1.11252094
89MP0000537_abnormal_urethra_morphology1.10434718
90MP0005377_hearing/vestibular/ear_phenot1.09708897
91MP0003878_abnormal_ear_physiology1.09708897
92MP0000678_abnormal_parathyroid_gland1.09641066
93MP0002161_abnormal_fertility/fecundity1.08777753
94MP0002210_abnormal_sex_determination1.08381031
95MP0005645_abnormal_hypothalamus_physiol1.07682941
96MP0004215_abnormal_myocardial_fiber1.06126072
97MP0002272_abnormal_nervous_system1.05815315
98MP0002254_reproductive_system_inflammat1.05680483
99MP0001119_abnormal_female_reproductive1.03626569
100MP0003119_abnormal_digestive_system1.02861723
101MP0006276_abnormal_autonomic_nervous1.01595633
102MP0002080_prenatal_lethality1.00923209
103MP0001790_abnormal_immune_system0.99995138
104MP0005387_immune_system_phenotype0.99995138
105MP0001764_abnormal_homeostasis0.95640442
106MP0000372_irregular_coat_pigmentation0.95024988
107MP0002735_abnormal_chemical_nociception0.94058158
108MP0000647_abnormal_sebaceous_gland0.93478795
109MP0001919_abnormal_reproductive_system0.92863487
110MP0005646_abnormal_pituitary_gland0.92408028
111MP0000631_abnormal_neuroendocrine_gland0.91866956
112MP0003186_abnormal_redox_activity0.91479457
113MP0002282_abnormal_trachea_morphology0.90658713
114MP0004484_altered_response_of0.90105602
115MP0005025_abnormal_response_to0.89759517
116MP0002557_abnormal_social/conspecific_i0.89460541
117MP0005000_abnormal_immune_tolerance0.88975975
118MP0001293_anophthalmia0.88283985
119MP0008875_abnormal_xenobiotic_pharmacok0.87872125
120MP0000566_synostosis0.86641157
121MP0010155_abnormal_intestine_physiology0.86254634
122MP0001929_abnormal_gametogenesis0.85724171
123MP0005395_other_phenotype0.85131164
124MP0000653_abnormal_sex_gland0.84638728
125MP0003890_abnormal_embryonic-extraembry0.84612672
126MP0002086_abnormal_extraembryonic_tissu0.83676598
127MP0004085_abnormal_heartbeat0.83635098
128MP0005670_abnormal_white_adipose0.83579314
129MP0002067_abnormal_sensory_capabilities0.83281855
130MP0003943_abnormal_hepatobiliary_system0.82716817
131MP0003941_abnormal_skin_development0.82679000
132MP0001145_abnormal_male_reproductive0.82236592
133MP0010307_abnormal_tumor_latency0.81456966
134MP0003567_abnormal_fetal_cardiomyocyte0.81029573
135MP0005332_abnormal_amino_acid0.80914686
136MP0006036_abnormal_mitochondrial_physio0.79401390
137MP0002638_abnormal_pupillary_reflex0.79118743
138MP0002160_abnormal_reproductive_system0.78864936
139MP0005391_vision/eye_phenotype0.78601764
140MP0005389_reproductive_system_phenotype0.78597946
141MP0000858_altered_metastatic_potential0.78570356
142MP0006035_abnormal_mitochondrial_morpho0.78413334
143MP0003315_abnormal_perineum_morphology0.77861370
144MP0003724_increased_susceptibility_to0.77857874
145MP0002653_abnormal_ependyma_morphology0.77315724
146MP0003137_abnormal_impulse_conducting0.76448851
147MP0002085_abnormal_embryonic_tissue0.76178553
148MP0005174_abnormal_tail_pigmentation0.75819060
149MP0002876_abnormal_thyroid_physiology0.75461867
150MP0008260_abnormal_autophagy0.73490054
151MP0004043_abnormal_pH_regulation0.72775973
152MP0003122_maternal_imprinting0.72634298
153MP0005384_cellular_phenotype0.72298979
154MP0004142_abnormal_muscle_tone0.71965885
155MP0006054_spinal_hemorrhage0.71390382
156MP0001501_abnormal_sleep_pattern0.71239031
157MP0001324_abnormal_eye_pigmentation0.71015850
158MP0002132_abnormal_respiratory_system0.70218017
159MP0004742_abnormal_vestibular_system0.69972049
160MP0005195_abnormal_posterior_eye0.69961610
161MP0002405_respiratory_system_inflammati0.69337547
162MP0005621_abnormal_cell_physiology0.69144276
163MP0004264_abnormal_extraembryonic_tissu0.68176509
164MP0004197_abnormal_fetal_growth/weight/0.67820327
165MP0002095_abnormal_skin_pigmentation0.66754334
166MP0002148_abnormal_hypersensitivity_rea0.65961857
167MP0000358_abnormal_cell_content/0.65546253

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.55426497
2Aplastic anemia (HP:0001915)3.83709697
3Abnormality of T cell physiology (HP:0011840)3.36469548
4Pancreatic cysts (HP:0001737)3.27291451
5Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.26044756
6Abnormality of alanine metabolism (HP:0010916)3.26044756
7Hyperalaninemia (HP:0003348)3.26044756
8Abnormality of the preputium (HP:0100587)3.22673380
9Chromsome breakage (HP:0040012)3.20540481
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.17044147
11Panhypogammaglobulinemia (HP:0003139)3.14777254
12Abnormality of chromosome stability (HP:0003220)3.12782953
13Molar tooth sign on MRI (HP:0002419)3.12675553
14Abnormality of midbrain morphology (HP:0002418)3.12675553
15Myelodysplasia (HP:0002863)3.05771927
16Pancreatic fibrosis (HP:0100732)3.03421663
17Nephronophthisis (HP:0000090)3.02057559
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.99660163
19Reticulocytopenia (HP:0001896)2.97738263
20Thrombocytosis (HP:0001894)2.93339182
21True hermaphroditism (HP:0010459)2.85566450
22Meckel diverticulum (HP:0002245)2.84761510
23Oral leukoplakia (HP:0002745)2.83497172
24Congenital stationary night blindness (HP:0007642)2.76314657
25Abnormality of the ileum (HP:0001549)2.76046424
26Attenuation of retinal blood vessels (HP:0007843)2.75106348
27Abnormality of T cells (HP:0002843)2.74455762
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.74183904
29IgM deficiency (HP:0002850)2.72265173
30Intestinal atresia (HP:0011100)2.66073018
31Abnormality of the labia minora (HP:0012880)2.64622053
32Microretrognathia (HP:0000308)2.63370097
33Abnormal hair whorl (HP:0010721)2.63260874
34Pancytopenia (HP:0001876)2.61897088
35Recurrent viral infections (HP:0004429)2.61583795
36Chronic hepatic failure (HP:0100626)2.58949495
37IgG deficiency (HP:0004315)2.58680983
38Abnormality of the renal medulla (HP:0100957)2.51525057
39Small intestinal stenosis (HP:0012848)2.50394404
40Duodenal stenosis (HP:0100867)2.50394404
41Ependymoma (HP:0002888)2.48507871
42Breast hypoplasia (HP:0003187)2.48456070
43Cleft eyelid (HP:0000625)2.44189941
44Medial flaring of the eyebrow (HP:0010747)2.41659494
4511 pairs of ribs (HP:0000878)2.40722078
46Abnormality of the anterior horn cell (HP:0006802)2.40005628
47Degeneration of anterior horn cells (HP:0002398)2.40005628
48Abnormal biliary tract physiology (HP:0012439)2.39851230
49Bile duct proliferation (HP:0001408)2.39851230
50Severe visual impairment (HP:0001141)2.38591744
51Patellar aplasia (HP:0006443)2.36496639
52Abnormal number of erythroid precursors (HP:0012131)2.35261059
53Type 2 muscle fiber atrophy (HP:0003554)2.35148781
54Colon cancer (HP:0003003)2.33932117
55Pendular nystagmus (HP:0012043)2.30777467
56Abnormality of cells of the erythroid lineage (HP:0012130)2.28550608
57Type I transferrin isoform profile (HP:0003642)2.28326271
58B lymphocytopenia (HP:0010976)2.27938100
59Abnormality of B cell number (HP:0010975)2.27938100
60Agnosia (HP:0010524)2.26874800
61Progressive inability to walk (HP:0002505)2.25945790
62Tubulointerstitial nephritis (HP:0001970)2.23517831
63Abnormality of macular pigmentation (HP:0008002)2.23129280
64Bone marrow hypocellularity (HP:0005528)2.22610730
65Amaurosis fugax (HP:0100576)2.22498282
66Glioma (HP:0009733)2.21687296
67Selective tooth agenesis (HP:0001592)2.21517117
68Abnormality of lateral ventricle (HP:0030047)2.18251475
69Sloping forehead (HP:0000340)2.17765386
70Increased serum lactate (HP:0002151)2.16853413
71Abnormality of glycolysis (HP:0004366)2.16395457
72Increased serum pyruvate (HP:0003542)2.16395457
73Abnormality of the renal cortex (HP:0011035)2.13926843
74Sclerocornea (HP:0000647)2.11707938
75Tubular atrophy (HP:0000092)2.11353682
76Abnormal rod and cone electroretinograms (HP:0008323)2.11058671
77Bony spicule pigmentary retinopathy (HP:0007737)2.10184574
78Abnormality of the duodenum (HP:0002246)2.09968595
79Aplasia/Hypoplasia of the patella (HP:0006498)2.08528823
80Aplasia/Hypoplasia of the fovea (HP:0008060)2.07751345
81Hypoplasia of the fovea (HP:0007750)2.07751345
82Neoplasm of the adrenal cortex (HP:0100641)2.06366009
83Muscle fiber atrophy (HP:0100295)2.05555912
84Lymphoma (HP:0002665)2.05503515
85Astrocytoma (HP:0009592)2.04916287
86Abnormality of the astrocytes (HP:0100707)2.04916287
87Pallor (HP:0000980)2.04912801
88Acute encephalopathy (HP:0006846)2.04243365
89Dynein arm defect of respiratory motile cilia (HP:0012255)2.03962673
90Absent/shortened dynein arms (HP:0200106)2.03962673
91Hypothermia (HP:0002045)2.03455889
92Hepatic necrosis (HP:0002605)2.02975920
93Reduced antithrombin III activity (HP:0001976)2.02770476
94Clubbing of toes (HP:0100760)2.02685716
95Abnormality of the prostate (HP:0008775)2.02180737
96Polydipsia (HP:0001959)2.01641556
97Abnormal drinking behavior (HP:0030082)2.01641556
98Neutropenia (HP:0001875)2.01202518
99Volvulus (HP:0002580)2.00948448
100Methylmalonic aciduria (HP:0012120)2.00532126
101Hepatocellular necrosis (HP:0001404)2.00486695
102Embryonal renal neoplasm (HP:0011794)2.00415958
103Cellular immunodeficiency (HP:0005374)1.99945976
104Inability to walk (HP:0002540)1.97894192
105Medulloblastoma (HP:0002885)1.97478947
106Genital tract atresia (HP:0001827)1.96182414
107Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93897631
108Astigmatism (HP:0000483)1.93872364
109Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93814726
110Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93814726
111Abnormal number of incisors (HP:0011064)1.93786711
112Abnormality of the carotid arteries (HP:0005344)1.92083966
113Neoplasm of the adrenal gland (HP:0100631)1.92048873
114Abnormality of the pons (HP:0007361)1.89700139
115Congenital primary aphakia (HP:0007707)1.89287398
116Type II lissencephaly (HP:0007260)1.88911210
117Acute necrotizing encephalopathy (HP:0006965)1.88883051
118Absent thumb (HP:0009777)1.88798913
119Rhabdomyosarcoma (HP:0002859)1.88797857
120Increased hepatocellular lipid droplets (HP:0006565)1.87816879
121Abolished electroretinogram (ERG) (HP:0000550)1.87227048
122Anencephaly (HP:0002323)1.87195567
123Increased CSF lactate (HP:0002490)1.87150818
124Recurrent fungal infections (HP:0002841)1.87004863
125Gait imbalance (HP:0002141)1.85955348
126Abnormal protein N-linked glycosylation (HP:0012347)1.85655162
127Abnormal protein glycosylation (HP:0012346)1.85655162
128Abnormal glycosylation (HP:0012345)1.85655162
129Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85655162
130Abnormal lung lobation (HP:0002101)1.84899840
131Vaginal atresia (HP:0000148)1.84709657
132Supernumerary spleens (HP:0009799)1.84155080
133Macrocytic anemia (HP:0001972)1.83661101
134Oligodactyly (hands) (HP:0001180)1.83613940
135Azoospermia (HP:0000027)1.83128391
136Aplasia/Hypoplasia of the thymus (HP:0010515)1.83097982
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.82874680
138Neoplasm of the colon (HP:0100273)1.82647610
139Hyperglycinuria (HP:0003108)1.82553598
140Acute myeloid leukemia (HP:0004808)1.82300603
141Progressive macrocephaly (HP:0004481)1.82164211
142Abnormality of serum amino acid levels (HP:0003112)1.81434925
143Hypoplasia of the pons (HP:0012110)1.81119091
144Triphalangeal thumb (HP:0001199)1.80972654
145Encephalitis (HP:0002383)1.80293006
146Gastrointestinal atresia (HP:0002589)1.79618026
147Polyuria (HP:0000103)1.79387762
148Megaloblastic anemia (HP:0001889)1.78973263
149Hyperglycinemia (HP:0002154)1.78760509
150Cystic liver disease (HP:0006706)1.78420498
151Pulmonary fibrosis (HP:0002206)1.78076419
152Renal Fanconi syndrome (HP:0001994)1.77650387
153Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77467834
154Posterior subcapsular cataract (HP:0007787)1.77052635
155Absent radius (HP:0003974)1.76067914
156Agammaglobulinemia (HP:0004432)1.75663329
157Nephrogenic diabetes insipidus (HP:0009806)1.74595104
158Chronic mucocutaneous candidiasis (HP:0002728)1.74539897
159Recurrent cutaneous fungal infections (HP:0011370)1.74539897
160Abnormal mitochondria in muscle tissue (HP:0008316)1.74457173
161Abnormal respiratory motile cilium morphology (HP:0005938)1.73919319
162Abnormal respiratory epithelium morphology (HP:0012253)1.73919319
163Abnormality of the parathyroid morphology (HP:0011766)1.73663969
164Mitochondrial inheritance (HP:0001427)1.72366886
165Nephroblastoma (Wilms tumor) (HP:0002667)1.72359617
166Abnormal spermatogenesis (HP:0008669)1.71527374
167Microvesicular hepatic steatosis (HP:0001414)1.70730615
168Female pseudohermaphroditism (HP:0010458)1.70617696
169Abnormality of T cell number (HP:0011839)1.70145905
170Methylmalonic acidemia (HP:0002912)1.69977021

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.54389704
2ACVR1B3.53015634
3BUB13.28678321
4MAP4K23.21779583
5EIF2AK13.20732426
6WEE13.09929666
7STK163.02568622
8WNK32.88988700
9TRIM282.74195939
10TSSK62.68733439
11NUAK12.61360068
12MST42.47393707
13EIF2AK32.42181245
14CDC72.39508354
15GRK12.35074846
16SIK32.33815117
17SRPK12.32575919
18PLK42.16643557
19INSRR2.09032718
20IRAK32.02323627
21PLK21.98657380
22BRSK21.95963770
23VRK11.91039449
24CCNB11.88796689
25STK38L1.87055271
26NEK11.78272512
27TLK11.74140211
28TGFBR11.67581991
29TXK1.62435093
30TTK1.61591131
31STK391.61015725
32RPS6KA41.59402378
33PNCK1.57198048
34NME21.51081974
35TAOK21.47544121
36OXSR11.42746973
37PLK11.41090073
38MAP3K121.39601300
39ERBB31.39123984
40KIT1.38106924
41VRK21.37797502
42PASK1.34456963
43IRAK41.34021507
44BMPR1B1.30706220
45EIF2AK21.30073132
46ATR1.29657699
47NEK21.29125604
48ZAK1.24275928
49PIM21.22903426
50FLT31.21628210
51MAP3K41.20879613
52PINK11.20534219
53OBSCN1.18920807
54PLK31.18357815
55TEC1.17582541
56MKNK11.17509832
57AURKB1.15143771
58RPS6KB21.14987434
59BTK1.12690430
60BCR1.12159950
61MAPK131.09172203
62PRPF4B1.06971872
63TAF11.05398060
64BRSK11.04791043
65PBK1.03786168
66NME11.03637187
67PIM11.01348870
68CDK80.97115674
69DYRK30.96625515
70CSNK1G10.95719506
71WNK40.94255190
72CDK190.93567666
73KSR10.90925998
74CHEK20.89452725
75BRAF0.87546913
76CDK70.87459348
77PDK30.86258401
78PDK40.86258401
79FGFR20.85433701
80STK100.84628415
81JAK30.82931452
82TNIK0.82707545
83CSNK1G20.82568932
84MAP3K60.81596809
85MAP4K10.80227298
86CSNK1G30.79688432
87ZAP700.79079136
88EEF2K0.78568313
89MKNK20.78056279
90MAPKAPK30.77971988
91DYRK20.77299870
92ATM0.76254752
93PAK30.72093211
94MAPK150.70688466
95TAOK30.70571024
96IKBKE0.70322719
97STK40.69105902
98CHEK10.68899902
99CDK40.67757786
100MAP3K140.67055001
101STK30.64206338
102CSNK1A1L0.64149824
103PRKCE0.63847882
104PRKCG0.63001395
105KDR0.62563249
106AKT30.62361938
107ADRBK20.62284866
108DAPK10.60533063
109CSF1R0.59757324
110BRD40.58665247
111RAF10.58093585
112MELK0.54346475
113CASK0.53559088
114TBK10.51042393
115CSNK2A20.50238243
116NLK0.49515952
117CSNK2A10.49220470
118MAPKAPK50.48510813
119BCKDK0.48138619
120MAP3K80.47994328
121AURKA0.47474105
122RPS6KA50.45562367
123FER0.44838695
124MARK10.44285346
125CDK30.43862962
126PTK2B0.43000621
127CHUK0.41853809
128MAP2K30.41632887
129CDK20.40787001
130IKBKB0.40623268
131ERBB40.40462339
132EPHA40.39824293
133NEK60.38038584
134PRKCI0.36981975
135LYN0.36108754
136CDK10.35693299
137EPHA20.35194232
138PDK20.34886449
139LCK0.34502305
140MAP2K60.34396318
141ITK0.34031148
142ADRBK10.33982871
143MAP3K130.33924898
144MAP2K70.33345924
145PHKG20.32623973
146PHKG10.32623973
147TIE10.30409292
148CAMK1G0.28923473
149CSNK1A10.27549298
150PKN10.25919964
151PRKG10.25588500
152MINK10.25146283
153CAMK2A0.24934583
154CSNK1D0.23914725
155STK240.23483632

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.72015550
2Base excision repair_Homo sapiens_hsa034103.91622425
3Mismatch repair_Homo sapiens_hsa034303.87090529
4Proteasome_Homo sapiens_hsa030503.36717086
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.27433818
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.25632136
7Homologous recombination_Homo sapiens_hsa034403.03426945
8RNA polymerase_Homo sapiens_hsa030202.86401420
9Spliceosome_Homo sapiens_hsa030402.82248222
10Non-homologous end-joining_Homo sapiens_hsa034502.77452137
11Ribosome_Homo sapiens_hsa030102.75756569
12Nucleotide excision repair_Homo sapiens_hsa034202.63547921
13RNA transport_Homo sapiens_hsa030132.59509920
14Cell cycle_Homo sapiens_hsa041102.57326632
15Pyrimidine metabolism_Homo sapiens_hsa002402.46759076
16Fanconi anemia pathway_Homo sapiens_hsa034602.33004658
17One carbon pool by folate_Homo sapiens_hsa006702.19842370
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17786727
19Basal transcription factors_Homo sapiens_hsa030222.07499000
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97209638
21Butanoate metabolism_Homo sapiens_hsa006501.97067331
22Phototransduction_Homo sapiens_hsa047441.95132570
23RNA degradation_Homo sapiens_hsa030181.93809753
24Fatty acid biosynthesis_Homo sapiens_hsa000611.72706885
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72698283
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67576056
27Primary immunodeficiency_Homo sapiens_hsa053401.66153891
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.62871238
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54753537
30Steroid biosynthesis_Homo sapiens_hsa001001.46480496
31Nitrogen metabolism_Homo sapiens_hsa009101.46383854
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.46312632
33Antigen processing and presentation_Homo sapiens_hsa046121.38421777
34p53 signaling pathway_Homo sapiens_hsa041151.37339923
35Purine metabolism_Homo sapiens_hsa002301.37234661
36Epstein-Barr virus infection_Homo sapiens_hsa051691.36731049
37Protein export_Homo sapiens_hsa030601.30355908
38Herpes simplex infection_Homo sapiens_hsa051681.26820625
39mRNA surveillance pathway_Homo sapiens_hsa030151.24980741
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13886799
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10635661
42Nicotine addiction_Homo sapiens_hsa050331.10596521
43Olfactory transduction_Homo sapiens_hsa047401.09956574
44Linoleic acid metabolism_Homo sapiens_hsa005911.09281699
45Tryptophan metabolism_Homo sapiens_hsa003801.08439251
46Caffeine metabolism_Homo sapiens_hsa002321.07985507
47Fatty acid elongation_Homo sapiens_hsa000621.07025743
48Fatty acid degradation_Homo sapiens_hsa000711.05358070
49Fatty acid metabolism_Homo sapiens_hsa012121.03666588
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.01393490
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98261954
52Peroxisome_Homo sapiens_hsa041460.98198411
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97992564
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94386255
55Taste transduction_Homo sapiens_hsa047420.94240890
56Ether lipid metabolism_Homo sapiens_hsa005650.93974942
57Measles_Homo sapiens_hsa051620.91115929
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90382416
59Legionellosis_Homo sapiens_hsa051340.88506437
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85592902
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84877226
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84414506
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.83841406
64Viral carcinogenesis_Homo sapiens_hsa052030.81725695
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.80086788
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78238972
67Selenocompound metabolism_Homo sapiens_hsa004500.77212015
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77151469
69Hematopoietic cell lineage_Homo sapiens_hsa046400.76859582
70Biosynthesis of amino acids_Homo sapiens_hsa012300.75804671
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74393061
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73995346
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.73133252
74Allograft rejection_Homo sapiens_hsa053300.72759829
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.70987401
76Glutathione metabolism_Homo sapiens_hsa004800.69277085
77Fat digestion and absorption_Homo sapiens_hsa049750.68368594
78Alzheimers disease_Homo sapiens_hsa050100.67962479
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67938585
80HTLV-I infection_Homo sapiens_hsa051660.67651903
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67564114
82Pentose phosphate pathway_Homo sapiens_hsa000300.67118930
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66709186
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66393977
85Chemical carcinogenesis_Homo sapiens_hsa052040.65632098
86Retinol metabolism_Homo sapiens_hsa008300.65227413
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65194996
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.61878215
89Shigellosis_Homo sapiens_hsa051310.61764766
90Carbon metabolism_Homo sapiens_hsa012000.61266931
91Fructose and mannose metabolism_Homo sapiens_hsa000510.60850308
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60385316
93Oocyte meiosis_Homo sapiens_hsa041140.59516942
94Systemic lupus erythematosus_Homo sapiens_hsa053220.59315546
95beta-Alanine metabolism_Homo sapiens_hsa004100.56438339
96Huntingtons disease_Homo sapiens_hsa050160.55576635
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54766830
98Hepatitis B_Homo sapiens_hsa051610.52060224
99Folate biosynthesis_Homo sapiens_hsa007900.51224608
100Autoimmune thyroid disease_Homo sapiens_hsa053200.50470588
101Cardiac muscle contraction_Homo sapiens_hsa042600.49803892
102Leishmaniasis_Homo sapiens_hsa051400.48478345
103Parkinsons disease_Homo sapiens_hsa050120.46805881
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46463595
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46284788
106Influenza A_Homo sapiens_hsa051640.46023892
107Apoptosis_Homo sapiens_hsa042100.44507327
108N-Glycan biosynthesis_Homo sapiens_hsa005100.44485789
109Oxidative phosphorylation_Homo sapiens_hsa001900.44388977
110Collecting duct acid secretion_Homo sapiens_hsa049660.43550923
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43476263
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42603518
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42376217
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42097189
115Vitamin B6 metabolism_Homo sapiens_hsa007500.41025175
116Regulation of autophagy_Homo sapiens_hsa041400.40025169
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39788533
118Arginine and proline metabolism_Homo sapiens_hsa003300.37197315
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.36696942
120Hedgehog signaling pathway_Homo sapiens_hsa043400.35903976
121GABAergic synapse_Homo sapiens_hsa047270.34705532
122Serotonergic synapse_Homo sapiens_hsa047260.34673886
123Circadian rhythm_Homo sapiens_hsa047100.33265220
124T cell receptor signaling pathway_Homo sapiens_hsa046600.33237906
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32715643
126Morphine addiction_Homo sapiens_hsa050320.31794763
127Lysine degradation_Homo sapiens_hsa003100.31642059
128Pyruvate metabolism_Homo sapiens_hsa006200.31139798
129Circadian entrainment_Homo sapiens_hsa047130.30701078
130Thyroid cancer_Homo sapiens_hsa052160.30197382
131Renin-angiotensin system_Homo sapiens_hsa046140.30144509
132TGF-beta signaling pathway_Homo sapiens_hsa043500.29515843
133Galactose metabolism_Homo sapiens_hsa000520.28878216
134Metabolic pathways_Homo sapiens_hsa011000.28543794
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28303169
136Graft-versus-host disease_Homo sapiens_hsa053320.28193754
137Arachidonic acid metabolism_Homo sapiens_hsa005900.28033076
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27970299
139Type I diabetes mellitus_Homo sapiens_hsa049400.26292310
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25381458
141Propanoate metabolism_Homo sapiens_hsa006400.24402199
142Colorectal cancer_Homo sapiens_hsa052100.23248846
143Vitamin digestion and absorption_Homo sapiens_hsa049770.22287511
144Tuberculosis_Homo sapiens_hsa051520.20966455
145TNF signaling pathway_Homo sapiens_hsa046680.19525638
146Rheumatoid arthritis_Homo sapiens_hsa053230.18290967
147Cyanoamino acid metabolism_Homo sapiens_hsa004600.18007726
148Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.16736883
149Notch signaling pathway_Homo sapiens_hsa043300.15790429
150B cell receptor signaling pathway_Homo sapiens_hsa046620.15370721
151Small cell lung cancer_Homo sapiens_hsa052220.12097919
152Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.09580993
153Viral myocarditis_Homo sapiens_hsa054160.09506757

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