MTPN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.64918375
2negative regulation of erythrocyte differentiation (GO:0045647)4.29394091
3locomotory exploration behavior (GO:0035641)3.95893295
4layer formation in cerebral cortex (GO:0021819)3.87635636
5proline transport (GO:0015824)3.86902293
6protein localization to endosome (GO:0036010)3.77233345
7positive regulation of gamma-delta T cell activation (GO:0046645)3.75851786
8hypotonic response (GO:0006971)3.67538040
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.61236621
10negative regulation of cell killing (GO:0031342)3.61236621
11glutamate secretion (GO:0014047)3.56514141
12synaptic vesicle exocytosis (GO:0016079)3.49445460
13regulation of platelet aggregation (GO:0090330)3.45661966
14synaptic vesicle docking involved in exocytosis (GO:0016081)3.41456922
15nuclear pore complex assembly (GO:0051292)3.40347274
16positive regulation of receptor recycling (GO:0001921)3.37897019
17COPI coating of Golgi vesicle (GO:0048205)3.34010487
18Golgi transport vesicle coating (GO:0048200)3.34010487
19regulation of short-term neuronal synaptic plasticity (GO:0048172)3.32302283
20regulation of synaptic vesicle exocytosis (GO:2000300)3.25334711
21negative regulation of protein localization to plasma membrane (GO:1903077)3.23264677
22regulation of synapse structural plasticity (GO:0051823)3.23114973
23exploration behavior (GO:0035640)3.22587307
24megakaryocyte development (GO:0035855)3.21225660
25clathrin coat assembly (GO:0048268)3.20580135
26positive regulation of cellular amide metabolic process (GO:0034250)3.16986759
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.13931934
28positive regulation of axon extension (GO:0045773)3.11428507
29positive regulation of chemokine biosynthetic process (GO:0045080)3.08963253
30cell adhesion mediated by integrin (GO:0033627)3.07285027
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.06026606
32negative regulation of homotypic cell-cell adhesion (GO:0034111)3.03234916
33platelet aggregation (GO:0070527)3.02963618
34Arp2/3 complex-mediated actin nucleation (GO:0034314)3.01270741
35vocalization behavior (GO:0071625)2.97889520
36positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.96775400
37regulation of glutamate receptor signaling pathway (GO:1900449)2.95960379
38detection of molecule of bacterial origin (GO:0032490)2.95601056
39regulation of long-term neuronal synaptic plasticity (GO:0048169)2.95307897
40positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.94099073
41cellular extravasation (GO:0045123)2.91730277
42axon extension (GO:0048675)2.91706806
43G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.91669571
44positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.90207589
45nuclear pore organization (GO:0006999)2.88648023
46regulation of early endosome to late endosome transport (GO:2000641)2.87641027
47regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.87571626
48regulation of leukocyte degranulation (GO:0043300)2.86312894
49vesicle transport along microtubule (GO:0047496)2.84919562
50cortical actin cytoskeleton organization (GO:0030866)2.82867459
51positive regulation of macrophage cytokine production (GO:0060907)2.82552614
52positive regulation of vesicle fusion (GO:0031340)2.78618808
53B cell receptor signaling pathway (GO:0050853)2.77808727
54detection of other organism (GO:0098543)2.74633573
55neuron projection extension (GO:1990138)2.73620026
56positive regulation of mast cell activation (GO:0033005)2.73372281
57regulation of synaptic vesicle transport (GO:1902803)2.71768884
58positive regulation of synapse maturation (GO:0090129)2.70128291
59neutrophil activation involved in immune response (GO:0002283)2.68809702
60regulation of mast cell degranulation (GO:0043304)2.68168346
61positive regulation of fibroblast migration (GO:0010763)2.68075438
62protein localization to synapse (GO:0035418)2.67544924
63Rap protein signal transduction (GO:0032486)2.66169416
64positive regulation by symbiont of host defense response (GO:0052509)2.65724561
65modulation by symbiont of host defense response (GO:0052031)2.65724561
66modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.65724561
67modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.65724561
68positive regulation by organism of defense response of other organism involved in symbiotic interact2.65724561
69modulation by symbiont of host immune response (GO:0052553)2.65724561
70regulation of B cell receptor signaling pathway (GO:0050855)2.63943936
71macrophage activation involved in immune response (GO:0002281)2.63364828
72response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.62539375
73response to host (GO:0075136)2.62539375
74response to host defenses (GO:0052200)2.62539375
75nerve growth factor signaling pathway (GO:0038180)2.62228545
76definitive hemopoiesis (GO:0060216)2.61466567
77nucleobase catabolic process (GO:0046113)2.59998636
78adenosine receptor signaling pathway (GO:0001973)2.59870837
79embryonic process involved in female pregnancy (GO:0060136)2.57993672
80actin nucleation (GO:0045010)2.57911699
81regulation of defense response to virus by virus (GO:0050690)2.57525650
82regulation of dendritic spine morphogenesis (GO:0061001)2.56456646
83response to muramyl dipeptide (GO:0032495)2.55300751
84positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.55185031
85axonal fasciculation (GO:0007413)2.54356039
86negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.54200270
87peptidyl-threonine modification (GO:0018210)2.54193423
88cell-substrate junction assembly (GO:0007044)2.54144680
89response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.52857072
90response to host immune response (GO:0052572)2.52857072
91dendritic spine morphogenesis (GO:0060997)2.52518769
92regulation of T-helper 2 cell differentiation (GO:0045628)2.52511935
93cellular response to thyroid hormone stimulus (GO:0097067)2.52424207
94peptidyl-threonine phosphorylation (GO:0018107)2.51832403
95positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.51500782
96positive regulation of lamellipodium assembly (GO:0010592)2.50604627
97detection of external biotic stimulus (GO:0098581)2.50173221
98pyrimidine nucleobase catabolic process (GO:0006208)2.49952906
99protein localization to microtubule (GO:0035372)2.48970902
100positive regulation of leukocyte degranulation (GO:0043302)2.48215602
101dendrite morphogenesis (GO:0048813)2.48001988
102antigen processing and presentation via MHC class Ib (GO:0002475)2.47618692
1033-UTR-mediated mRNA stabilization (GO:0070935)2.47576395
104regulation of myeloid leukocyte mediated immunity (GO:0002886)2.46745643
105cellular response to interferon-alpha (GO:0035457)2.46552278
106positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.46131995
107positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.46111920
108regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.46111920
109cellular response to nerve growth factor stimulus (GO:1990090)2.45922992
110response to nerve growth factor (GO:1990089)2.45922992
111platelet formation (GO:0030220)2.45215507
112neutrophil activation (GO:0042119)2.44974413
113pore complex assembly (GO:0046931)2.43430080
114regulation of nucleobase-containing compound transport (GO:0032239)2.43002487
115neuron recognition (GO:0008038)2.42895130
116phagocytosis, engulfment (GO:0006911)2.42608656
117vesicle coating (GO:0006901)2.41290400
118regulation of homotypic cell-cell adhesion (GO:0034110)2.41192921
119cytoskeletal anchoring at plasma membrane (GO:0007016)2.40984449
120establishment of nucleus localization (GO:0040023)2.40545100
121regulation of mast cell activation involved in immune response (GO:0033006)2.40367233
122regulation of macrophage cytokine production (GO:0010935)2.39879172
123pinocytosis (GO:0006907)2.39531422
124thrombin receptor signaling pathway (GO:0070493)2.39410151
125cortical cytoskeleton organization (GO:0030865)2.39133178
126organelle transport along microtubule (GO:0072384)2.38664503
127hepatocyte apoptotic process (GO:0097284)2.38657711
128positive regulation of macrophage differentiation (GO:0045651)2.38507549
129detection of bacterium (GO:0016045)2.38480326
130positive regulation of B cell differentiation (GO:0045579)2.38367322
131regulation of RNA export from nucleus (GO:0046831)2.38174359
132myeloid cell activation involved in immune response (GO:0002275)2.38143171
133regulation of neuronal synaptic plasticity (GO:0048168)2.38064364
134germinal center formation (GO:0002467)2.37402805
135myeloid cell development (GO:0061515)2.37320976
136cell-substrate adherens junction assembly (GO:0007045)2.36983103
137focal adhesion assembly (GO:0048041)2.36983103
138positive regulation of nitric-oxide synthase activity (GO:0051000)2.36372772
139negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.36355927
140barbed-end actin filament capping (GO:0051016)2.35193943
141response to laminar fluid shear stress (GO:0034616)2.34533979
142activation of protein kinase A activity (GO:0034199)2.34330129
143regulation of clathrin-mediated endocytosis (GO:2000369)2.34271483
144regulation of integrin activation (GO:0033623)2.33641888
145granulocyte activation (GO:0036230)2.33368750
146regulation of chemokine biosynthetic process (GO:0045073)2.32953204
147regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.32549842
148neurotransmitter secretion (GO:0007269)2.32246028
149homotypic cell-cell adhesion (GO:0034109)2.31743839
150leukocyte migration involved in inflammatory response (GO:0002523)2.30748353
151regulation of amyloid precursor protein catabolic process (GO:1902991)2.30744297
152adherens junction assembly (GO:0034333)2.28561083
153ionotropic glutamate receptor signaling pathway (GO:0035235)2.27577983
154Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.27549296
155positive regulation of filopodium assembly (GO:0051491)2.25211296
156lipopolysaccharide-mediated signaling pathway (GO:0031663)2.24402635
157negative regulation of microtubule polymerization (GO:0031115)2.23112545
158axon extension involved in axon guidance (GO:0048846)2.22923587
159neuron projection extension involved in neuron projection guidance (GO:1902284)2.22923587
160positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.22033206
161regulation of dendritic spine development (GO:0060998)2.21505943
162Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.20660398
163immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.20660398
164Fc-gamma receptor signaling pathway (GO:0038094)2.20660398
165negative regulation of interleukin-17 production (GO:0032700)2.20484630
166positive regulation of dendritic spine morphogenesis (GO:0061003)2.19247510
167response to peptidoglycan (GO:0032494)2.17396640
168regulation of filopodium assembly (GO:0051489)2.16854138
169regulation of axon extension (GO:0030516)2.16525791
170NLS-bearing protein import into nucleus (GO:0006607)2.16436364
171regulation of NFAT protein import into nucleus (GO:0051532)2.15660750
172central nervous system projection neuron axonogenesis (GO:0021952)2.14728929
173regulation of regulated secretory pathway (GO:1903305)2.12717108
174stress fiber assembly (GO:0043149)2.12463502
175regulation of synaptic plasticity (GO:0048167)2.12012881
176positive regulation of bone resorption (GO:0045780)2.11982764
177positive regulation of bone remodeling (GO:0046852)2.11982764
178hydrogen peroxide biosynthetic process (GO:0050665)2.10961847
179positive regulation of dendrite morphogenesis (GO:0050775)2.10718751

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human3.79787918
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.39023943
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.00083370
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.91777031
5MYC_22102868_ChIP-Seq_BL_Human2.86224687
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.62922656
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.61512189
8SCL_19346495_ChIP-Seq_HPC-7_Human2.59897527
9E2F7_22180533_ChIP-Seq_HELA_Human2.56335571
10EZH2_22144423_ChIP-Seq_EOC_Human2.39010748
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.30743955
12WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.28379615
13TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.24253021
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.18905148
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11888531
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.10591271
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.07778431
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.06556199
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03564165
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01371257
21VDR_21846776_ChIP-Seq_THP-1_Human2.00226539
22TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.99578143
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.98908758
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98554004
25CLOCK_20551151_ChIP-Seq_293T_Human1.93062087
26* RUNX1_22412390_ChIP-Seq_EML_Mouse1.92130944
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91205621
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.90728120
29GATA1_19941826_ChIP-Seq_K562_Human1.88979539
30GATA1_22025678_ChIP-Seq_K562_Human1.84927870
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.84257111
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.84257111
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.82599644
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.81283397
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80968130
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79421520
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77746992
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77175128
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76939741
40VDR_24763502_ChIP-Seq_THP-1_Human1.75006419
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73423390
42NRF2_20460467_ChIP-Seq_MEFs_Mouse1.72131699
43NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.72131699
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71432806
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.68938000
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67033016
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67025493
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65863539
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.64864743
50NCOR1_26117541_ChIP-Seq_K562_Human1.62786574
51MAF_26560356_Chip-Seq_TH1_Human1.62554744
52GATA1_22383799_ChIP-Seq_G1ME_Mouse1.62284895
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60031775
54* SPI1_23547873_ChIP-Seq_NB4_Human1.58606510
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.58035566
56* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57610991
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.55353190
58AR_21572438_ChIP-Seq_LNCaP_Human1.54895601
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53249030
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52500806
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.52422673
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52046116
63GATA2_19941826_ChIP-Seq_K562_Human1.51873175
64IGF1R_20145208_ChIP-Seq_DFB_Human1.50860535
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.49728118
66TP53_18474530_ChIP-ChIP_U2OS_Human1.48835873
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.47165102
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46571271
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45411453
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.44851671
71GBX2_23144817_ChIP-Seq_PC3_Human1.43234333
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42983394
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41686160
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41400186
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40265945
76TP53_16413492_ChIP-PET_HCT116_Human1.40096583
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39701882
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38959751
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38745647
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38266496
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37355370
82RXR_22108803_ChIP-Seq_LS180_Human1.35413216
83GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34825959
84UTX_26944678_Chip-Seq_JUKART_Human1.34798532
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34444924
86STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34281453
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33716224
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32030341
89PU_27001747_Chip-Seq_BMDM_Mouse1.30576955
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29251640
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28893478
92KDM2B_26808549_Chip-Seq_K562_Human1.28828026
93REST_21632747_ChIP-Seq_MESCs_Mouse1.28813799
94ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28100464
95RUNX_20019798_ChIP-Seq_JUKART_Human1.27780356
96NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.27494023
97STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27455850
98SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26698003
99SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26698003
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26393533
101MYB_26560356_Chip-Seq_TH2_Human1.25254227
102ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24071047
103GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23113471
104* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22711483
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22703814
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22117962
107BRD4_25478319_ChIP-Seq_HGPS_Human1.21637152
108MYB_26560356_Chip-Seq_TH1_Human1.20628405
109VDR_24787735_ChIP-Seq_THP-1_Human1.20252693
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19466384
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19424729
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17104606
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.16121464
114* SPI1_23127762_ChIP-Seq_K562_Human1.14959976
115TFEB_21752829_ChIP-Seq_HELA_Human1.14702931
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14116879
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13271847
118EZH2_27304074_Chip-Seq_ESCs_Mouse1.12839711
119JUN_21703547_ChIP-Seq_K562_Human1.11726464
120E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11596830
121ZNF263_19887448_ChIP-Seq_K562_Human1.11264016
122MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11099942
123EED_16625203_ChIP-ChIP_MESCs_Mouse1.10723098
124* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09596290
125KDM2B_26808549_Chip-Seq_DND41_Human1.08069177
126SMAD4_21799915_ChIP-Seq_A2780_Human1.07518669
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07038784
128* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06624063
129SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05922139
130* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05377458
131GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05211074
132TCF7_22412390_ChIP-Seq_EML_Mouse1.04890935
133SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04749216
134* SOX2_21211035_ChIP-Seq_LN229_Gbm1.03873038
135P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03434973
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02378442
137RACK7_27058665_Chip-Seq_MCF-7_Human1.02268631
138CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02161962
139* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01718572
140GATA1_19941827_ChIP-Seq_MEL86_Mouse1.01064082
141RING1B_27294783_Chip-Seq_NPCs_Mouse1.00841778
142CJUN_26792858_Chip-Seq_BT549_Human1.00433311
143IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99863975
144YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99757155
145DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99071950
146PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99042288
147AR_25329375_ChIP-Seq_VCAP_Human0.98993749
148SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98780232
149* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98246006
150TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98127227
151LXR_22292898_ChIP-Seq_THP-1_Human0.97485776
152REST_18959480_ChIP-ChIP_MESCs_Mouse0.97341254
153FOXO3_23340844_ChIP-Seq_DLD1_Human0.96957709
154DROSHA_22980978_ChIP-Seq_HELA_Human0.96735827
155P300_19829295_ChIP-Seq_ESCs_Human0.96502756
156TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95571441
157STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95520481
158EZH2_27294783_Chip-Seq_ESCs_Mouse0.94875801
159WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93856975
160UBF1/2_26484160_Chip-Seq_HMECs_Human0.93468756
161BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92579281
162AR_19668381_ChIP-Seq_PC3_Human0.91200892
163* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90776516
164KDM2B_26808549_Chip-Seq_JURKAT_Human0.90211604
165SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89659420
166ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88594141
167ARNT_22903824_ChIP-Seq_MCF-7_Human0.88362404
168KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88227013

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.21390014
2MP0003303_peritoneal_inflammation4.05175266
3MP0004858_abnormal_nervous_system3.21866473
4MP0000569_abnormal_digit_pigmentation2.98612643
5MP0003705_abnormal_hypodermis_morpholog2.71408386
6MP0003635_abnormal_synaptic_transmissio2.53512431
7MP0010352_gastrointestinal_tract_polyps2.52555823
8MP0008260_abnormal_autophagy2.33314248
9MP0010234_abnormal_vibrissa_follicle2.32119033
10MP0002063_abnormal_learning/memory/cond2.28626710
11MP0003828_pulmonary_edema2.26982064
12MP0005409_darkened_coat_color2.26470423
13MP0004270_analgesia2.17114543
14MP0005451_abnormal_body_composition2.13923754
15MP0003880_abnormal_central_pattern2.10817565
16MP0009780_abnormal_chondrocyte_physiolo2.09915016
17MP0003172_abnormal_lysosome_physiology1.95862524
18MP0003436_decreased_susceptibility_to1.90819464
19MP0000465_gastrointestinal_hemorrhage1.84963873
20MP0005058_abnormal_lysosome_morphology1.83646016
21MP0004510_myositis1.82352736
22MP0003724_increased_susceptibility_to1.80866354
23MP0003091_abnormal_cell_migration1.78919692
24MP0008004_abnormal_stomach_pH1.76900444
25MP0003191_abnormal_cellular_cholesterol1.76326687
26MP0002009_preneoplasia1.74765979
27MP0005623_abnormal_meninges_morphology1.73078845
28MP0003656_abnormal_erythrocyte_physiolo1.72802102
29MP0003183_abnormal_peptide_metabolism1.72771261
30MP0003075_altered_response_to1.70672936
31MP0003300_gastrointestinal_ulcer1.67047601
32MP0000604_amyloidosis1.64663394
33MP0009745_abnormal_behavioral_response1.64651906
34MP0005257_abnormal_intraocular_pressure1.63347304
35MP0001968_abnormal_touch/_nociception1.60157734
36MP0003329_amyloid_beta_deposits1.58889458
37MP0002064_seizures1.55116499
38MP0002396_abnormal_hematopoietic_system1.55021888
39MP0005076_abnormal_cell_differentiation1.53282056
40MP0001835_abnormal_antigen_presentation1.51755925
41MP0004811_abnormal_neuron_physiology1.49904147
42MP0003763_abnormal_thymus_physiology1.49101485
43MP0003453_abnormal_keratinocyte_physiol1.48569170
44MP0008438_abnormal_cutaneous_collagen1.46618943
45MP0008057_abnormal_DNA_replication1.46515313
46MP0002572_abnormal_emotion/affect_behav1.45592981
47MP0002877_abnormal_melanocyte_morpholog1.45583077
48MP0001851_eye_inflammation1.45382821
49MP0004185_abnormal_adipocyte_glucose1.45333169
50MP0002733_abnormal_thermal_nociception1.44646772
51MP0001348_abnormal_lacrimal_gland1.43671447
52MP0000778_abnormal_nervous_system1.42392166
53MP0002398_abnormal_bone_marrow1.42375757
54MP0006082_CNS_inflammation1.41608360
55MP0003448_altered_tumor_morphology1.39402717
56MP0002735_abnormal_chemical_nociception1.35476698
57MP0002734_abnormal_mechanical_nocicepti1.35042553
58MP0005166_decreased_susceptibility_to1.32748147
59MP0002419_abnormal_innate_immunity1.30844885
60MP0009785_altered_susceptibility_to1.30709307
61MP0005000_abnormal_immune_tolerance1.30102078
62MP0009046_muscle_twitch1.29158090
63MP0005167_abnormal_blood-brain_barrier1.27681961
64MP0005621_abnormal_cell_physiology1.25587143
65MP0001849_ear_inflammation1.23968558
66MP0002166_altered_tumor_susceptibility1.22603724
67MP0002909_abnormal_adrenal_gland1.22141615
68MP0001440_abnormal_grooming_behavior1.21147933
69MP0002998_abnormal_bone_remodeling1.21055383
70MP0002148_abnormal_hypersensitivity_rea1.20744082
71MP0001501_abnormal_sleep_pattern1.17887413
72MP0001533_abnormal_skeleton_physiology1.15217579
73MP0005023_abnormal_wound_healing1.14329407
74MP0001915_intracranial_hemorrhage1.12680100
75MP0005275_abnormal_skin_tensile1.10875006
76MP0000685_abnormal_immune_system1.09963283
77MP0000858_altered_metastatic_potential1.09553780
78MP0000703_abnormal_thymus_morphology1.09451650
79MP0005248_abnormal_Harderian_gland1.07826976
80MP0002184_abnormal_innervation1.07725767
81MP0001800_abnormal_humoral_immune1.07288828
82MP0001970_abnormal_pain_threshold1.05706507
83MP0002722_abnormal_immune_system1.05279010
84MP0003221_abnormal_cardiomyocyte_apopto1.03862152
85MP0001958_emphysema1.01218421
86MP0002736_abnormal_nociception_after1.00784350
87MP0002452_abnormal_antigen_presenting1.00033974
88MP0010155_abnormal_intestine_physiology0.99911285
89MP0008961_abnormal_basal_metabolism0.99868656
90MP0002429_abnormal_blood_cell0.99163038
91MP0003279_aneurysm0.99028319
92MP0000716_abnormal_immune_system0.98284583
93MP0005164_abnormal_response_to0.98199743
94MP0010386_abnormal_urinary_bladder0.97115171
95MP0003122_maternal_imprinting0.97028190
96MP0005666_abnormal_adipose_tissue0.96924295
97MP0003566_abnormal_cell_adhesion0.96686618
98MP0006054_spinal_hemorrhage0.96561939
99MP0001299_abnormal_eye_distance/0.95422969
100MP0004084_abnormal_cardiac_muscle0.95213705
101MP0000343_altered_response_to0.94938368
102MP0004272_abnormal_basement_membrane0.94833692
103MP0002086_abnormal_extraembryonic_tissu0.92745781
104MP0009278_abnormal_bone_marrow0.92153537
105MP0002060_abnormal_skin_morphology0.91114822
106MP0003690_abnormal_glial_cell0.90860060
107MP0000350_abnormal_cell_proliferation0.90679409
108MP0002090_abnormal_vision0.90119951
109MP0003879_abnormal_hair_cell0.89861780
110MP0002405_respiratory_system_inflammati0.89180658
111MP0005464_abnormal_platelet_physiology0.89112456
112MP0000689_abnormal_spleen_morphology0.88338185
113MP0005384_cellular_phenotype0.87774143
114MP0003633_abnormal_nervous_system0.87131695
115MP0001730_embryonic_growth_arrest0.85549928
116MP0010307_abnormal_tumor_latency0.83819001
117MP0005499_abnormal_olfactory_system0.83560695
118MP0005394_taste/olfaction_phenotype0.83560695
119MP0000015_abnormal_ear_pigmentation0.82844742
120MP0001853_heart_inflammation0.82728422
121MP0000955_abnormal_spinal_cord0.82511457
122MP0002796_impaired_skin_barrier0.82456857
123MP0004883_abnormal_blood_vessel0.82433546
124MP0004808_abnormal_hematopoietic_stem0.80638495
125MP0006138_congestive_heart_failure0.80210167
126MP0005025_abnormal_response_to0.80049243
127MP0001819_abnormal_immune_cell0.79762072
128MP0004233_abnormal_muscle_weight0.79708004
129MP0005390_skeleton_phenotype0.79338590
130MP0000490_abnormal_crypts_of0.79104099
131MP0002420_abnormal_adaptive_immunity0.77841169
132MP0009764_decreased_sensitivity_to0.77832712
133MP0004381_abnormal_hair_follicle0.77111127
134MP0004130_abnormal_muscle_cell0.76868993
135MP0001790_abnormal_immune_system0.76094064
136MP0005387_immune_system_phenotype0.76094064
137MP0005501_abnormal_skin_physiology0.75836738
138MP0004924_abnormal_behavior0.75582049
139MP0005386_behavior/neurological_phenoty0.75582049
140MP0009053_abnormal_anal_canal0.75491142
141MP0005397_hematopoietic_system_phenotyp0.73268795
142MP0001545_abnormal_hematopoietic_system0.73268795
143MP0002006_tumorigenesis0.73210888
144MP0005197_abnormal_uvea_morphology0.73127135
145MP0002557_abnormal_social/conspecific_i0.73074639
146MP0004947_skin_inflammation0.72770274
147MP0002896_abnormal_bone_mineralization0.72761640
148MP0000767_abnormal_smooth_muscle0.72200882
149MP0009333_abnormal_splenocyte_physiolog0.71988217
150MP0005187_abnormal_penis_morphology0.70657064
151MP0002723_abnormal_immune_serum0.70639106
152MP0001177_atelectasis0.66198841
153MP0003795_abnormal_bone_structure0.65057731
154MP0008874_decreased_physiological_sensi0.64592883
155MP0002067_abnormal_sensory_capabilities0.64069559
156MP0002295_abnormal_pulmonary_circulatio0.63451075

Predicted human phenotypes

RankGene SetZ-score
1Papilledema (HP:0001085)4.41927545
2Increased mean platelet volume (HP:0011877)4.41156790
3Abnormal platelet volume (HP:0011876)4.37299789
4Prolonged bleeding time (HP:0003010)4.13937462
5Disinhibition (HP:0000734)3.65261786
6Inappropriate behavior (HP:0000719)3.53096028
7Amyotrophic lateral sclerosis (HP:0007354)3.50989523
8Menorrhagia (HP:0000132)3.50730201
9Apathy (HP:0000741)3.35053771
10Diminished motivation (HP:0000745)3.29046115
11Mutism (HP:0002300)3.10883164
12Petechiae (HP:0000967)3.10133790
13Spontaneous hematomas (HP:0007420)3.09241129
14Epistaxis (HP:0000421)3.09003012
15Gingival bleeding (HP:0000225)3.01601514
16Visual hallucinations (HP:0002367)3.00233343
17Purpura (HP:0000979)2.86187847
18Eczematoid dermatitis (HP:0000976)2.82191017
19Subacute progressive viral hepatitis (HP:0006572)2.81537475
20Focal seizures (HP:0007359)2.78153697
21Recurrent abscess formation (HP:0002722)2.75117841
22Increased cerebral lipofuscin (HP:0011813)2.74595705
23Absent frontal sinuses (HP:0002688)2.68496938
24Protrusio acetabuli (HP:0003179)2.67623928
25Ankyloglossia (HP:0010296)2.61618036
26Focal motor seizures (HP:0011153)2.60315589
27Supranuclear gaze palsy (HP:0000605)2.58663420
28Recurrent bacterial skin infections (HP:0005406)2.58619944
29Abnormal platelet function (HP:0011869)2.56941248
30Impaired platelet aggregation (HP:0003540)2.56941248
31Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.55056088
32Osteolytic defects of the hand bones (HP:0009699)2.52021836
33Osteolytic defects of the phalanges of the hand (HP:0009771)2.52021836
34Amblyopia (HP:0000646)2.49866461
35Peritonitis (HP:0002586)2.48720562
36Hepatoblastoma (HP:0002884)2.42862465
37Epileptic encephalopathy (HP:0200134)2.40800944
38Polycythemia (HP:0001901)2.39568653
39Abnormality of macrophages (HP:0004311)2.38784866
40Recurrent gram-negative bacterial infections (HP:0005420)2.34415607
41Dilatation of the ascending aorta (HP:0005111)2.33570061
42Abnormality of oral frenula (HP:0000190)2.33075348
43Cellulitis (HP:0100658)2.31733974
44Abnormality of the lower motor neuron (HP:0002366)2.24384625
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.23258259
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.22744162
47Myokymia (HP:0002411)2.22074807
48Excessive salivation (HP:0003781)2.21770720
49Drooling (HP:0002307)2.21770720
50Atrophy/Degeneration involving motor neurons (HP:0007373)2.21269590
51Mediastinal lymphadenopathy (HP:0100721)2.19352588
52Papillary thyroid carcinoma (HP:0002895)2.19015795
53Distal lower limb amyotrophy (HP:0008944)2.15667941
54Viral hepatitis (HP:0006562)2.14634354
55Cerebral inclusion bodies (HP:0100314)2.13677877
56Genu recurvatum (HP:0002816)2.09315532
57Absence seizures (HP:0002121)2.07679916
58Insomnia (HP:0100785)2.04615216
59Hematochezia (HP:0002573)2.04047346
60Relative macrocephaly (HP:0004482)2.02907537
61Arterial tortuosity (HP:0005116)2.02595445
62Hyperacusis (HP:0010780)2.00220055
63Deep philtrum (HP:0002002)2.00146088
64Abnormality of skeletal muscle fiber size (HP:0012084)1.99974458
65Stereotypic behavior (HP:0000733)1.99715360
66Increased variability in muscle fiber diameter (HP:0003557)1.98959760
67Heterochromia iridis (HP:0001100)1.98917863
68Dialeptic seizures (HP:0011146)1.98312024
69Cortical dysplasia (HP:0002539)1.97387104
70Orthostatic hypotension (HP:0001278)1.96677023
71Generalized tonic-clonic seizures (HP:0002069)1.96577478
72Fatigue (HP:0012378)1.95590831
73Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.94904600
74Transitional cell carcinoma of the bladder (HP:0006740)1.94885196
75Bladder neoplasm (HP:0009725)1.94610886
76Bladder carcinoma (HP:0002862)1.94610886
77Vascular tortuosity (HP:0004948)1.94473625
78Poor eye contact (HP:0000817)1.93736407
79Hyperventilation (HP:0002883)1.92617048
80Shallow orbits (HP:0000586)1.92428961
81Micronodular cirrhosis (HP:0001413)1.91287781
82Spinal cord lesions (HP:0100561)1.91026945
83Syringomyelia (HP:0003396)1.91026945
84Lower limb amyotrophy (HP:0007210)1.90994900
85Abnormality of glycolipid metabolism (HP:0010969)1.90982372
86Abnormality of liposaccharide metabolism (HP:0010968)1.90982372
87Abnormality of glycosphingolipid metabolism (HP:0004343)1.90982372
88Recurrent viral infections (HP:0004429)1.89545994
89Asymmetry of the thorax (HP:0001555)1.89079030
90Disproportionate tall stature (HP:0001519)1.88591016
91Bruising susceptibility (HP:0000978)1.88477425
92Genetic anticipation (HP:0003743)1.88258004
93Macroorchidism (HP:0000053)1.88001370
94Premature rupture of membranes (HP:0001788)1.86763194
95Action tremor (HP:0002345)1.85236607
96Hand muscle atrophy (HP:0009130)1.82952177
97Conjunctival telangiectasia (HP:0000524)1.82147660
98Termporal pattern (HP:0011008)1.80431505
99Insidious onset (HP:0003587)1.80431505
100Spondylolisthesis (HP:0003302)1.80137029
101Open mouth (HP:0000194)1.80069746
102Abnormality of the common coagulation pathway (HP:0010990)1.79845099
103Vertebral compression fractures (HP:0002953)1.79615835
104Aortic aneurysm (HP:0004942)1.79307948
105Abnormality of binocular vision (HP:0011514)1.78447545
106Diplopia (HP:0000651)1.78447545
107Slow saccadic eye movements (HP:0000514)1.78381505
108Intellectual disability, profound (HP:0002187)1.77867088
109Increased density of long bones (HP:0006392)1.77597215
110Shoulder girdle muscle weakness (HP:0003547)1.77194283
111Abnormality of the motor neurons (HP:0002450)1.76808025
112Abnormal neuron morphology (HP:0012757)1.76808025
113Depression (HP:0000716)1.75528723
114Mitral valve prolapse (HP:0001634)1.75499735
115Wormian bones (HP:0002645)1.75485005
116Dysmetric saccades (HP:0000641)1.75351327
117Leiomyosarcoma (HP:0100243)1.74868234
118Uterine leiomyosarcoma (HP:0002891)1.74868234
119Gingivitis (HP:0000230)1.72489107
120Achilles tendon contracture (HP:0001771)1.72221995
121Abnormality of the vasculature of the conjunctiva (HP:0008054)1.71822599
122Pointed chin (HP:0000307)1.71009656
123Osteomyelitis (HP:0002754)1.69769725
124Myocardial infarction (HP:0001658)1.69609378
125Chronic obstructive pulmonary disease (HP:0006510)1.69344289
126Obstructive lung disease (HP:0006536)1.69344289
127Centrally nucleated skeletal muscle fibers (HP:0003687)1.68965089
128Testicular neoplasm (HP:0010788)1.67772984
129Upper limb amyotrophy (HP:0009129)1.65449616
130Distal upper limb amyotrophy (HP:0007149)1.65449616
131Atonic seizures (HP:0010819)1.65362214
132Cerebral aneurysm (HP:0004944)1.65230615
133Neurofibrillary tangles (HP:0002185)1.65061872
134Arterial thrombosis (HP:0004420)1.63900942
135Acute myeloid leukemia (HP:0004808)1.63842759
136Decreased motor nerve conduction velocity (HP:0003431)1.63116718
137Akinesia (HP:0002304)1.62912400
138Resting tremor (HP:0002322)1.62044873
139Abnormal large intestine physiology (HP:0012700)1.61709865
140Polyphagia (HP:0002591)1.61074208
141Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.60160908
142Hypercortisolism (HP:0001578)1.59560760
143Abnormal social behavior (HP:0012433)1.59436453
144Impaired social interactions (HP:0000735)1.59436453
145Bowel incontinence (HP:0002607)1.58791849
146Aortic dissection (HP:0002647)1.58284934
147Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.57752634
148Abnormality of salivation (HP:0100755)1.57515066
149Obstructive sleep apnea (HP:0002870)1.57201405
150Buphthalmos (HP:0000557)1.57057106
151Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.56810570
152Mitral regurgitation (HP:0001653)1.56582118
153Increased connective tissue (HP:0009025)1.55148563
154Abnormality of the Achilles tendon (HP:0005109)1.54967198
155Overgrowth (HP:0001548)1.53826696
156Aneurysm (HP:0002617)1.52940403
157Urticaria (HP:0001025)1.52886424
158Broad face (HP:0000283)1.52541471
159Hyperparathyroidism (HP:0000843)1.51981913
160Chest pain (HP:0100749)1.51572490
161Coarse hair (HP:0002208)1.51176559
162Increased IgE level (HP:0003212)1.50997784
163Long palpebral fissure (HP:0000637)1.50664247
164Gastrointestinal inflammation (HP:0004386)1.50003834
165Thrombocytosis (HP:0001894)1.49550530
166Renal cell carcinoma (HP:0005584)1.48488368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.97472617
2MARK13.82284749
3MAP3K93.71360148
4PRPF4B3.66605933
5MINK12.85826183
6KSR22.51562816
7EPHA42.46670983
8KSR12.46542390
9SCYL22.43712651
10NTRK32.36480231
11MAP2K32.23126924
12ERN12.05042284
13NTRK11.93578902
14ERBB31.88087789
15CAMKK11.85855165
16PLK21.85033738
17TRIB31.77729486
18LATS21.77126235
19MAP3K121.75421390
20IRAK31.75332820
21DAPK21.74560066
22EIF2AK11.74462835
23SIK21.70366917
24EEF2K1.68466766
25GRK51.67643893
26PAK61.66199163
27SMG11.63188602
28MAP2K41.54592703
29MAP3K41.52117366
30ICK1.50734121
31BLK1.42431262
32TESK11.40717802
33ZAP701.36146638
34MAP3K21.31203727
35BTK1.30603896
36SIK31.29370121
37GRK61.28302149
38DDR21.26366770
39SGK31.22269426
40TTN1.22085681
41NEK91.21746345
42CAMKK21.21622876
43YES11.21427564
44MOS1.17374678
45MATK1.17313339
46DAPK11.16889381
47TYRO31.13889463
48MAP3K61.13132081
49TYK21.12814105
50RAF11.12146057
51MAP2K71.11101631
52RET1.10287465
53IRAK41.09656129
54MAP3K131.08833196
55EPHB11.06924656
56PAK31.04785263
57TAOK21.04068515
58TAOK11.04035264
59PKN21.02420982
60RIPK11.01905041
61PDGFRA1.01165705
62CDK141.00336136
63MAP3K30.99889586
64ARAF0.99754406
65FES0.99120152
66CDK50.95023043
67CDK120.94928796
68NTRK20.93823742
69CSF1R0.92740204
70MAP3K50.91113514
71CDK180.90254221
72FGFR40.90253681
73IRAK20.90060783
74SGK20.87342964
75FRK0.87223407
76TEC0.86693780
77FGFR30.86292059
78ALK0.85706593
79PIK3CG0.83388963
80TBK10.83240304
81CDK150.82710270
82FGR0.79737482
83WNK10.78097660
84STK240.77722302
85SIK10.77659225
86CCNB10.76308682
87MAP3K140.75326263
88SYK0.75249504
89LIMK10.75109806
90MAPK120.74994083
91PTK2B0.74768679
92MAP3K80.74443883
93CLK10.73587827
94PAK20.72144093
95STK30.71963906
96TRPM70.70788587
97MAP2K10.70582148
98STK40.70125138
99ABL20.68724568
100BMX0.67539430
101PAK40.66424603
102CDK11A0.66353189
103DMPK0.66242331
104PTK60.63769619
105FYN0.62878639
106HCK0.62708157
107MAP3K100.62339532
108BRAF0.61438509
109HIPK20.60612319
110PRKCG0.60029937
111EGFR0.59742651
112FER0.58025857
113BRD40.56963332
114PIM20.56884935
115RPS6KA40.56175708
116CDK40.53076100
117MTOR0.52627753
118PDK10.52469275
119EPHB20.50939622
120TGFBR20.50716017
121MAP4K10.49743518
122STK100.49555818
123ILK0.49405548
124DYRK20.48015789
125MAPK70.47184600
126PTK20.44746665
127MARK20.44733652
128JAK30.41928164
129MAP3K10.41854138
130SGK2230.40660147
131SGK4940.40660147
132SRC0.40508851
133PAK10.39087222
134CSNK1G20.38800159
135PRKCZ0.38579019
136PRKCH0.38462190
137LYN0.38180186
138CSK0.37732766
139PDGFRB0.37713944
140RPS6KA20.36635469
141BMPR20.36626303
142IRAK10.36374893
143JAK20.36142498
144JAK10.34579933
145PDPK10.34467704
146CDK60.33554668
147LRRK20.33124381
148PRKCD0.32701565
149ADRBK10.32323506
150TESK20.32161459

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.20692367
2Long-term potentiation_Homo sapiens_hsa047201.81735804
3Synaptic vesicle cycle_Homo sapiens_hsa047211.77353347
4Acute myeloid leukemia_Homo sapiens_hsa052211.69605301
5Leishmaniasis_Homo sapiens_hsa051401.66465631
6Thyroid cancer_Homo sapiens_hsa052161.62715108
7Glioma_Homo sapiens_hsa052141.52125748
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50667705
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43792552
10Tuberculosis_Homo sapiens_hsa051521.43365303
11Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39325648
12Salmonella infection_Homo sapiens_hsa051321.37607088
13Neurotrophin signaling pathway_Homo sapiens_hsa047221.37542961
14Osteoclast differentiation_Homo sapiens_hsa043801.36240871
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35057208
16Shigellosis_Homo sapiens_hsa051311.34292160
17Dopaminergic synapse_Homo sapiens_hsa047281.33842011
18Olfactory transduction_Homo sapiens_hsa047401.30875756
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30676234
20B cell receptor signaling pathway_Homo sapiens_hsa046621.29232912
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27231559
22Pertussis_Homo sapiens_hsa051331.26999956
23Circadian entrainment_Homo sapiens_hsa047131.25875091
24VEGF signaling pathway_Homo sapiens_hsa043701.22943958
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21573767
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19634818
27Glutamatergic synapse_Homo sapiens_hsa047241.19577531
28Nicotine addiction_Homo sapiens_hsa050331.19520187
29Phagosome_Homo sapiens_hsa041451.19514230
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19451618
31Bladder cancer_Homo sapiens_hsa052191.19151385
32Amphetamine addiction_Homo sapiens_hsa050311.16235065
33Small cell lung cancer_Homo sapiens_hsa052221.15520911
34African trypanosomiasis_Homo sapiens_hsa051431.15284604
35TNF signaling pathway_Homo sapiens_hsa046681.14901660
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14705171
37Long-term depression_Homo sapiens_hsa047301.13537568
38Cholinergic synapse_Homo sapiens_hsa047251.13095260
39Renin secretion_Homo sapiens_hsa049241.12837449
40Oxytocin signaling pathway_Homo sapiens_hsa049211.12542408
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11138718
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11044945
43GnRH signaling pathway_Homo sapiens_hsa049121.10491540
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10407526
45GABAergic synapse_Homo sapiens_hsa047271.09698976
46Prostate cancer_Homo sapiens_hsa052151.09522435
47Pancreatic cancer_Homo sapiens_hsa052121.08583627
48Central carbon metabolism in cancer_Homo sapiens_hsa052301.06762331
49Gap junction_Homo sapiens_hsa045401.06300664
50Colorectal cancer_Homo sapiens_hsa052101.05771855
51Salivary secretion_Homo sapiens_hsa049701.05597920
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05278667
53mTOR signaling pathway_Homo sapiens_hsa041501.05056784
54Chronic myeloid leukemia_Homo sapiens_hsa052201.05039849
55Type I diabetes mellitus_Homo sapiens_hsa049401.04712937
56Chemokine signaling pathway_Homo sapiens_hsa040621.04357883
57Adherens junction_Homo sapiens_hsa045201.04330995
58Estrogen signaling pathway_Homo sapiens_hsa049151.03506103
59Measles_Homo sapiens_hsa051621.03439499
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03184582
61Morphine addiction_Homo sapiens_hsa050321.02825414
62Platelet activation_Homo sapiens_hsa046111.00361682
63Axon guidance_Homo sapiens_hsa043600.99751952
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.97511899
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97257919
66ErbB signaling pathway_Homo sapiens_hsa040120.95495144
67Gastric acid secretion_Homo sapiens_hsa049710.94525027
68Legionellosis_Homo sapiens_hsa051340.93811444
69Viral carcinogenesis_Homo sapiens_hsa052030.93532240
70Proteoglycans in cancer_Homo sapiens_hsa052050.93148287
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92965541
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92779104
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92518792
74Amoebiasis_Homo sapiens_hsa051460.91645755
75Inositol phosphate metabolism_Homo sapiens_hsa005620.91130562
76Non-small cell lung cancer_Homo sapiens_hsa052230.90878501
77ECM-receptor interaction_Homo sapiens_hsa045120.90398135
78Insulin signaling pathway_Homo sapiens_hsa049100.90314050
79Viral myocarditis_Homo sapiens_hsa054160.90272673
80MicroRNAs in cancer_Homo sapiens_hsa052060.90249278
81Endometrial cancer_Homo sapiens_hsa052130.89739463
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89530380
83Rheumatoid arthritis_Homo sapiens_hsa053230.88237721
84Toxoplasmosis_Homo sapiens_hsa051450.87693695
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87031021
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.86975096
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86575601
88Hepatitis B_Homo sapiens_hsa051610.85875912
89Renal cell carcinoma_Homo sapiens_hsa052110.85793880
90HIF-1 signaling pathway_Homo sapiens_hsa040660.84787789
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82963648
92Hepatitis C_Homo sapiens_hsa051600.82899474
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82880927
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82268257
95Collecting duct acid secretion_Homo sapiens_hsa049660.82264586
96Vibrio cholerae infection_Homo sapiens_hsa051100.81249128
97Rap1 signaling pathway_Homo sapiens_hsa040150.80844138
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.80553604
99Dorso-ventral axis formation_Homo sapiens_hsa043200.80538923
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80054363
101Malaria_Homo sapiens_hsa051440.79739615
102Serotonergic synapse_Homo sapiens_hsa047260.78938690
103Focal adhesion_Homo sapiens_hsa045100.78891535
104Endocytosis_Homo sapiens_hsa041440.78393680
105Hematopoietic cell lineage_Homo sapiens_hsa046400.78314799
106Cocaine addiction_Homo sapiens_hsa050300.78171530
107FoxO signaling pathway_Homo sapiens_hsa040680.77247461
108Type II diabetes mellitus_Homo sapiens_hsa049300.76500236
109Notch signaling pathway_Homo sapiens_hsa043300.75606827
110Graft-versus-host disease_Homo sapiens_hsa053320.75105908
111Prolactin signaling pathway_Homo sapiens_hsa049170.73820723
112cAMP signaling pathway_Homo sapiens_hsa040240.72497498
113Lysosome_Homo sapiens_hsa041420.71593028
114Oocyte meiosis_Homo sapiens_hsa041140.71546192
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71365534
116Melanogenesis_Homo sapiens_hsa049160.70926240
117T cell receptor signaling pathway_Homo sapiens_hsa046600.70033580
118Prion diseases_Homo sapiens_hsa050200.70012527
119Apoptosis_Homo sapiens_hsa042100.68465606
120Other glycan degradation_Homo sapiens_hsa005110.68298614
121Influenza A_Homo sapiens_hsa051640.67859381
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66547000
123Melanoma_Homo sapiens_hsa052180.66503392
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.66493099
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66280884
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65775622
127Choline metabolism in cancer_Homo sapiens_hsa052310.65633338
128Pentose phosphate pathway_Homo sapiens_hsa000300.65016375
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.64104707
130HTLV-I infection_Homo sapiens_hsa051660.63203464
131Pathways in cancer_Homo sapiens_hsa052000.62608060
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58818109
133Herpes simplex infection_Homo sapiens_hsa051680.58470834
134MAPK signaling pathway_Homo sapiens_hsa040100.54145564
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52975508
136Ras signaling pathway_Homo sapiens_hsa040140.52729100

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