MTR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sodium ion export (GO:0071436)6.79419704
2cell communication by electrical coupling involved in cardiac conduction (GO:0086064)6.72326515
3relaxation of cardiac muscle (GO:0055119)6.64882435
4regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.05910489
5cell communication by electrical coupling (GO:0010644)5.58413412
6nuclear pore complex assembly (GO:0051292)5.24948171
7nuclear pore organization (GO:0006999)5.21421537
8cellular sodium ion homeostasis (GO:0006883)4.77665564
9negative regulation of cytosolic calcium ion concentration (GO:0051481)4.48634597
10positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.43704800
11positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.41912692
12regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.41039708
13cell communication involved in cardiac conduction (GO:0086065)4.38100988
14membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.36627014
15pore complex assembly (GO:0046931)4.34551766
16protein localization to kinetochore (GO:0034501)4.28756549
17DNA unwinding involved in DNA replication (GO:0006268)4.16654176
18mitotic chromosome condensation (GO:0007076)4.15838268
19mitotic nuclear envelope disassembly (GO:0007077)4.13488604
20positive regulation of sodium ion transmembrane transporter activity (GO:2000651)4.09401813
21interkinetic nuclear migration (GO:0022027)3.99016423
22relaxation of muscle (GO:0090075)3.98624247
23cytoplasmic mRNA processing body assembly (GO:0033962)3.92268504
24regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.87910704
25embryonic heart tube development (GO:0035050)3.84713208
26nuclear envelope disassembly (GO:0051081)3.84221126
27membrane disassembly (GO:0030397)3.84221126
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.77828689
29membrane repolarization during action potential (GO:0086011)3.70182189
30DNA replication initiation (GO:0006270)3.69496277
31DNA strand elongation involved in DNA replication (GO:0006271)3.66089766
32cellular potassium ion homeostasis (GO:0030007)3.64918728
33cardiac myofibril assembly (GO:0055003)3.64677256
34protein localization to chromosome, centromeric region (GO:0071459)3.64378343
35IMP biosynthetic process (GO:0006188)3.64318094
36mitotic sister chromatid cohesion (GO:0007064)3.59544587
37cardiac muscle contraction (GO:0060048)3.56606073
38DNA strand elongation (GO:0022616)3.54784109
39myotube differentiation (GO:0014902)3.53796549
40DNA duplex unwinding (GO:0032508)3.48770489
41regulation of histone H3-K9 methylation (GO:0051570)3.48433687
42DNA geometric change (GO:0032392)3.48247279
43telomere maintenance via semi-conservative replication (GO:0032201)3.41183161
44myofibril assembly (GO:0030239)3.39526518
45response to caffeine (GO:0031000)3.37954245
46attachment of spindle microtubules to kinetochore (GO:0008608)3.34938575
47phospholipid translocation (GO:0045332)3.34895939
48lipid translocation (GO:0034204)3.34895939
49telomere maintenance via recombination (GO:0000722)3.28142386
50IMP metabolic process (GO:0046040)3.26907455
51monoubiquitinated protein deubiquitination (GO:0035520)3.26523537
52mitotic metaphase plate congression (GO:0007080)3.25648276
53regulation of spindle organization (GO:0090224)3.25408863
54DNA replication checkpoint (GO:0000076)3.25002277
55mitotic recombination (GO:0006312)3.22170985
56DNA replication-dependent nucleosome assembly (GO:0006335)3.20823326
57DNA replication-dependent nucleosome organization (GO:0034723)3.20823326
58regulation of translational fidelity (GO:0006450)3.19371815
59folic acid-containing compound biosynthetic process (GO:0009396)3.15160952
60regulation of pigment cell differentiation (GO:0050932)3.12393032
61piRNA metabolic process (GO:0034587)3.11210395
62negative regulation of histone methylation (GO:0031061)3.10390223
63DNA conformation change (GO:0071103)3.10096289
64nucleus localization (GO:0051647)3.09443398
65kinetochore organization (GO:0051383)3.08325035
66nuclear envelope organization (GO:0006998)3.08171810
67positive regulation of chromosome segregation (GO:0051984)3.07021383
68metaphase plate congression (GO:0051310)3.05680334
69nucleobase biosynthetic process (GO:0046112)3.05665530
70gene silencing by RNA (GO:0031047)3.05285684
71regulation of mitotic spindle organization (GO:0060236)3.04993602
72negative regulation of DNA repair (GO:0045738)3.03794103
73mitotic sister chromatid segregation (GO:0000070)3.03373865
74peptidyl-lysine dimethylation (GO:0018027)3.02319467
75sister chromatid segregation (GO:0000819)3.01365035
76positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.00460258
77startle response (GO:0001964)3.00294183
78regulation of sister chromatid cohesion (GO:0007063)2.99741712
79cardiac muscle cell development (GO:0055013)2.99587373
80protein K11-linked deubiquitination (GO:0035871)2.98067545
81dosage compensation (GO:0007549)2.97719964
82pre-miRNA processing (GO:0031054)2.96898124
83regulation of cardiac muscle contraction (GO:0055117)2.95228461
84protein localization to chromosome (GO:0034502)2.94299649
85chromosome condensation (GO:0030261)2.93899350
86meiotic chromosome segregation (GO:0045132)2.93252313
87mitotic G1 DNA damage checkpoint (GO:0031571)2.92832984
88telomere maintenance (GO:0000723)2.91348432
89heart morphogenesis (GO:0003007)2.90213260
90telomere organization (GO:0032200)2.88998397
91DNA packaging (GO:0006323)2.88465375
92phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.87758844
93sarcoplasmic reticulum calcium ion transport (GO:0070296)2.87612686
94positive regulation of sodium ion transmembrane transport (GO:1902307)2.87485351
95translesion synthesis (GO:0019985)2.87096616
96positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.85994832
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.85994832
98positive regulation of mitotic sister chromatid separation (GO:1901970)2.85994832
99gastrulation with mouth forming second (GO:0001702)2.84995753
100heterochromatin organization (GO:0070828)2.84892741
101cardiac cell development (GO:0055006)2.83774333
102negative regulation of chromosome segregation (GO:0051985)2.83004502
103chromatin remodeling at centromere (GO:0031055)2.82571409
104regulation of chromosome segregation (GO:0051983)2.81571118
105maturation of SSU-rRNA (GO:0030490)2.81117232
106regulation of sarcomere organization (GO:0060297)2.80351338
107cardiac muscle hypertrophy (GO:0003300)2.79459898
108regulation of centriole replication (GO:0046599)2.78826136
109positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.78134631
110regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.78134631
111coronary vasculature morphogenesis (GO:0060977)2.78099775
112lymphangiogenesis (GO:0001946)2.77662676
113Golgi to endosome transport (GO:0006895)2.77383697
114regulation of telomere maintenance via telomerase (GO:0032210)2.77251998
115regulation of mitotic metaphase/anaphase transition (GO:0030071)2.76688329
116DNA replication-independent nucleosome assembly (GO:0006336)2.76465538
117DNA replication-independent nucleosome organization (GO:0034724)2.76465538
118negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.76349738
119negative regulation of sister chromatid segregation (GO:0033046)2.76349738
120negative regulation of mitotic sister chromatid separation (GO:2000816)2.76349738
121negative regulation of mitotic sister chromatid segregation (GO:0033048)2.76349738
122regulation of RNA export from nucleus (GO:0046831)2.75927875
123spindle assembly checkpoint (GO:0071173)2.75049866
124regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.74947317
125regulation of DNA endoreduplication (GO:0032875)2.74828859
126negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.74778903
127CENP-A containing nucleosome assembly (GO:0034080)2.74433148
128synaptonemal complex assembly (GO:0007130)2.74311764
129telomere maintenance via telomere lengthening (GO:0010833)2.74210043
130chromatin assembly (GO:0031497)2.73881015
131regulation of posttranscriptional gene silencing (GO:0060147)2.73142336
132regulation of gene silencing by miRNA (GO:0060964)2.73142336
133regulation of gene silencing by RNA (GO:0060966)2.73142336
134regulation of striated muscle contraction (GO:0006942)2.72989230
135formation of translation preinitiation complex (GO:0001731)2.72770500
136regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.72743641
137regulation of translational termination (GO:0006449)2.71458547
138chromatin assembly or disassembly (GO:0006333)2.71228664
139mitotic spindle assembly checkpoint (GO:0007094)2.70465676
140positive regulation of developmental pigmentation (GO:0048087)2.70328638
141regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.70073383
142regulation of protein polyubiquitination (GO:1902914)2.70067280
143regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.69697918
144spindle checkpoint (GO:0031577)2.69492293
145positive regulation of potassium ion transmembrane transport (GO:1901381)2.69220049
146peptidyl-threonine phosphorylation (GO:0018107)2.68005869
147regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.67663426
148snRNA processing (GO:0016180)2.67552149
149embryonic foregut morphogenesis (GO:0048617)2.67374605
150histone H2A monoubiquitination (GO:0035518)2.67334859
151negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.67313282
152nucleotide-excision repair, DNA gap filling (GO:0006297)2.66865856
153purine nucleobase biosynthetic process (GO:0009113)2.66815102
154striated muscle hypertrophy (GO:0014897)2.63512918
155embryonic retina morphogenesis in camera-type eye (GO:0060059)2.63488593
156ribosomal small subunit assembly (GO:0000028)2.63141636
157regulation of mitotic sister chromatid separation (GO:0010965)2.62995777
158regulation of mitotic sister chromatid segregation (GO:0033047)2.62995777
159regulation of sister chromatid segregation (GO:0033045)2.62995777
160mitotic spindle checkpoint (GO:0071174)2.62848713
161striated muscle contraction (GO:0006941)2.62602070
162regulation of potassium ion transmembrane transporter activity (GO:1901016)2.62510156
163establishment of chromosome localization (GO:0051303)2.62246197
164regulation of nucleobase-containing compound transport (GO:0032239)2.61724571
165regulation of the force of heart contraction (GO:0002026)2.60904468
166regulation of calcium ion transmembrane transporter activity (GO:1901019)2.57300573
167regulation of calcium ion transmembrane transport (GO:1903169)2.57300573
168histone-serine phosphorylation (GO:0035404)2.54548049
169relaxation of smooth muscle (GO:0044557)2.53269638
170histone H3-K9 demethylation (GO:0033169)2.49417812
171sodium ion homeostasis (GO:0055078)2.48516881
172negative regulation of neurotransmitter secretion (GO:0046929)2.47366279
173negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.46906853
174artery development (GO:0060840)2.46347505
175negative regulation of potassium ion transmembrane transport (GO:1901380)2.46245899
176positive regulation of protein import into nucleus, translocation (GO:0033160)2.44406145
177peptidyl-threonine modification (GO:0018210)2.43705893
178response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.41114968
179positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.40847477
180regulation of centrosome duplication (GO:0010824)2.38968575
181positive regulation of muscle hypertrophy (GO:0014742)2.38869805
182positive regulation of cardiac muscle hypertrophy (GO:0010613)2.38869805
183labyrinthine layer development (GO:0060711)2.37114046
184regulation of relaxation of muscle (GO:1901077)2.36095731
185sister chromatid cohesion (GO:0007062)2.35687868

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.38473431
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.58610417
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.59267126
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.17944373
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.11515744
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.06156578
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99921560
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.94301107
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79415024
10GBX2_23144817_ChIP-Seq_PC3_Human2.77857748
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64713518
12MYC_22102868_ChIP-Seq_BL_Human2.46420823
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.34824697
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33890970
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.32141465
16* FUS_26573619_Chip-Seq_HEK293_Human2.31769664
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23802165
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21960886
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18880541
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.18614832
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.17431182
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.12825814
23* E2F1_21310950_ChIP-Seq_MCF-7_Human2.09259462
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07612712
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06039920
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.04200910
27AR_21572438_ChIP-Seq_LNCaP_Human2.02815980
28TAF15_26573619_Chip-Seq_HEK293_Human2.02788978
29TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse2.01707218
30* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99830381
31CIITA_25753668_ChIP-Seq_RAJI_Human1.98243456
32TP53_16413492_ChIP-PET_HCT116_Human1.96157877
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94434564
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.92467363
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88780387
36AR_21909140_ChIP-Seq_LNCAP_Human1.88238495
37EZH2_22144423_ChIP-Seq_EOC_Human1.87592987
38CTNNB1_20460455_ChIP-Seq_HCT116_Human1.85546551
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82616684
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80602014
41SMAD4_21799915_ChIP-Seq_A2780_Human1.78143375
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75459289
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74389442
44VDR_21846776_ChIP-Seq_THP-1_Human1.74246354
45STAT3_23295773_ChIP-Seq_U87_Human1.72625640
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71318680
47* EST1_17652178_ChIP-ChIP_JURKAT_Human1.70930216
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.67729367
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66922468
50XRN2_22483619_ChIP-Seq_HELA_Human1.64947783
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64112118
52* ETS1_20019798_ChIP-Seq_JURKAT_Human1.58067391
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57436428
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57370444
55EWS_26573619_Chip-Seq_HEK293_Human1.57084061
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55146533
57VDR_23849224_ChIP-Seq_CD4+_Human1.54661652
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.53899462
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52764572
60* TCF4_23295773_ChIP-Seq_U87_Human1.51786806
61* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50983850
62* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50863335
63FOXP3_21729870_ChIP-Seq_TREG_Human1.50647948
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48773396
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44919229
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44346185
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44111799
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42748019
69* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41610131
70KDM5A_27292631_Chip-Seq_BREAST_Human1.40949626
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.40590405
72* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.40247150
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.39646204
74TFEB_21752829_ChIP-Seq_HELA_Human1.38164871
75AHR_22903824_ChIP-Seq_MCF-7_Human1.37974659
76FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.37973099
77SCL_19346495_ChIP-Seq_HPC-7_Human1.37789338
78* GATA1_22025678_ChIP-Seq_K562_Human1.37684832
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.37095344
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35027538
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34829108
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34382757
83JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34002310
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33342930
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31837701
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31704264
87* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31039234
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31035394
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30649928
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27793100
91* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27590578
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27317365
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27317365
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.27309750
95P300_19829295_ChIP-Seq_ESCs_Human1.27136910
96GABP_19822575_ChIP-Seq_HepG2_Human1.27101432
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.26764893
98TCF7_22412390_ChIP-Seq_EML_Mouse1.26431690
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.26091207
100SOX9_26525672_Chip-Seq_HEART_Mouse1.25833584
101SPI1_23547873_ChIP-Seq_NB4_Human1.25664188
102SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24906301
103SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23363483
104GABP_17652178_ChIP-ChIP_JURKAT_Human1.22861895
105STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.20837567
106ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20734890
107* TCF4_18268006_ChIP-ChIP_LS174T_Human1.19476146
108UTX_26944678_Chip-Seq_JUKART_Human1.18519965
109* SOX2_21211035_ChIP-Seq_LN229_Gbm1.18434456
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18299030
111* MAF_26560356_Chip-Seq_TH1_Human1.18257234
112NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17891021
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17512180
114TP63_19390658_ChIP-ChIP_HaCaT_Human1.17097607
115FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16158959
116KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15988337
117SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15554377
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15494602
119ER_23166858_ChIP-Seq_MCF-7_Human1.15126108
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14579632
121TTF2_22483619_ChIP-Seq_HELA_Human1.13834631
122DCP1A_22483619_ChIP-Seq_HELA_Human1.13401076
123TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12651471
124SMAD_19615063_ChIP-ChIP_OVARY_Human1.12120349
125MYB_26560356_Chip-Seq_TH1_Human1.11635054
126EZH2_27294783_Chip-Seq_NPCs_Mouse1.11155656
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10977460
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10730033
129* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10524723
130FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10384762
131ELK1_19687146_ChIP-ChIP_HELA_Human1.09817880
132BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09616119
133BP1_19119308_ChIP-ChIP_Hs578T_Human1.09475285
134ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09190265
135E2F1_18555785_Chip-Seq_ESCs_Mouse1.09183646
136CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08820760
137NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08242365
138FOXA2_19822575_ChIP-Seq_HepG2_Human1.08059354
139IRF8_22096565_ChIP-ChIP_GC-B_Human1.08046245
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07756986
141POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07756986
142ISL1_27105846_Chip-Seq_CPCs_Mouse1.07739285
143* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06755687
144STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06302975
145STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06096258
146RUNX1_22412390_ChIP-Seq_EML_Mouse1.04838017
147NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04807344
148DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04765275
149CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04660782
150NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04538594
151MYB_26560356_Chip-Seq_TH2_Human1.04067855
152FLI1_21867929_ChIP-Seq_TH2_Mouse1.03925806
153IGF1R_20145208_ChIP-Seq_DFB_Human1.03347411
154* TBL1_22424771_ChIP-Seq_293T_Human1.03022083
155IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02748208
156* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02144525
157CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02132048
158GF1B_26923725_Chip-Seq_HPCs_Mouse1.00898432
159POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00593783
160UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00082791
161EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00000377
162MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99255942
163IRF8_21731497_ChIP-ChIP_J774_Mouse0.99251504
164BRD4_25478319_ChIP-Seq_HGPS_Human0.99207684
165SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99191642
166NOTCH1_21737748_ChIP-Seq_TLL_Human0.98229442
167HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97960066
168VDR_22108803_ChIP-Seq_LS180_Human0.97737266
169PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97097056
170RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96719171
171* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95160012
172* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94141100
173* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93867817
174PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93857839
175GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93800521
176CMYC_18555785_Chip-Seq_ESCs_Mouse0.93627797
177TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92465509
178SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92207524
179CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91939465
180NANOG_21062744_ChIP-ChIP_HESCs_Human0.91713324
181MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91641332
182TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91188726
183GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87885718
184SALL1_21062744_ChIP-ChIP_HESCs_Human0.87112919
185KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87070179
186BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87059343
187NCOR1_26117541_ChIP-Seq_K562_Human0.84873035
188VDR_24763502_ChIP-Seq_THP-1_Human0.84831576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia3.67877245
2MP0010094_abnormal_chromosome_stability3.62985035
3MP0003111_abnormal_nucleus_morphology3.14084659
4MP0008057_abnormal_DNA_replication3.01747897
5MP0003077_abnormal_cell_cycle2.95244432
6MP0008877_abnormal_DNA_methylation2.88605905
7MP0003693_abnormal_embryo_hatching2.85891313
8MP0002396_abnormal_hematopoietic_system2.77038370
9MP0004957_abnormal_blastocyst_morpholog2.67597388
10MP0004084_abnormal_cardiac_muscle2.39943310
11MP0008007_abnormal_cellular_replicative2.37849636
12MP0010352_gastrointestinal_tract_polyps2.32113132
13MP0010307_abnormal_tumor_latency2.23322167
14MP0008058_abnormal_DNA_repair2.14756634
15MP0004484_altered_response_of2.14454028
16MP0004808_abnormal_hematopoietic_stem2.12159294
17MP0003195_calcinosis1.87017282
18MP0001730_embryonic_growth_arrest1.82160234
19MP0000569_abnormal_digit_pigmentation1.74679405
20MP0003566_abnormal_cell_adhesion1.73566826
21MP0000350_abnormal_cell_proliferation1.71825616
22MP0001661_extended_life_span1.71459799
23MP0003950_abnormal_plasma_membrane1.67430262
24MP0005397_hematopoietic_system_phenotyp1.66967042
25MP0001545_abnormal_hematopoietic_system1.66967042
26MP0005187_abnormal_penis_morphology1.64848866
27MP0009278_abnormal_bone_marrow1.64458809
28MP0003646_muscle_fatigue1.63851712
29MP0004145_abnormal_muscle_electrophysio1.63409610
30MP0005171_absent_coat_pigmentation1.63312995
31MP0002108_abnormal_muscle_morphology1.61413580
32MP0003984_embryonic_growth_retardation1.58676074
33MP0005076_abnormal_cell_differentiation1.58243765
34MP0003786_premature_aging1.56685516
35MP0005380_embryogenesis_phenotype1.56399023
36MP0001672_abnormal_embryogenesis/_devel1.56399023
37MP0002088_abnormal_embryonic_growth/wei1.55109683
38MP0005503_abnormal_tendon_morphology1.53912543
39MP0004130_abnormal_muscle_cell1.50451423
40MP0003567_abnormal_fetal_cardiomyocyte1.48780040
41MP0005058_abnormal_lysosome_morphology1.47483872
42MP0005409_darkened_coat_color1.44140314
43MP0010630_abnormal_cardiac_muscle1.42134014
44MP0003937_abnormal_limbs/digits/tail_de1.40878303
45MP0004510_myositis1.38517414
46MP0006138_congestive_heart_failure1.38090668
47MP0001697_abnormal_embryo_size1.37883773
48MP0004272_abnormal_basement_membrane1.37036393
49MP0003221_abnormal_cardiomyocyte_apopto1.36183297
50MP0002086_abnormal_extraembryonic_tissu1.34691978
51MP0003890_abnormal_embryonic-extraembry1.31368553
52MP0008995_early_reproductive_senescence1.31307102
53MP0000751_myopathy1.31276574
54MP0004036_abnormal_muscle_relaxation1.31186669
55MP0003705_abnormal_hypodermis_morpholog1.27500277
56MP0000313_abnormal_cell_death1.27079382
57* MP0002080_prenatal_lethality1.25561820
58MP0003763_abnormal_thymus_physiology1.25338566
59MP0008932_abnormal_embryonic_tissue1.25186856
60MP0002398_abnormal_bone_marrow1.24950031
61MP0000759_abnormal_skeletal_muscle1.24727398
62MP0002972_abnormal_cardiac_muscle1.22905703
63MP0003828_pulmonary_edema1.22333377
64MP0000490_abnormal_crypts_of1.22252312
65MP0002019_abnormal_tumor_incidence1.21603982
66MP0000703_abnormal_thymus_morphology1.20254058
67MP0005620_abnormal_muscle_contractility1.20146557
68MP0008438_abnormal_cutaneous_collagen1.20067002
69MP0004197_abnormal_fetal_growth/weight/1.18527296
70MP0001879_abnormal_lymphatic_vessel1.18187966
71MP0005330_cardiomyopathy1.17889718
72MP0000689_abnormal_spleen_morphology1.16970457
73MP0003935_abnormal_craniofacial_develop1.15206157
74MP0004087_abnormal_muscle_fiber1.15194641
75MP0003123_paternal_imprinting1.15093051
76MP0002084_abnormal_developmental_patter1.14918340
77MP0002166_altered_tumor_susceptibility1.14861203
78MP0002722_abnormal_immune_system1.14704836
79MP0009697_abnormal_copulation1.13190422
80MP0001299_abnormal_eye_distance/1.12993991
81MP0005369_muscle_phenotype1.11368081
82MP0003943_abnormal_hepatobiliary_system1.10164612
83MP0002085_abnormal_embryonic_tissue1.07143787
84MP0002269_muscular_atrophy1.07125640
85MP0000749_muscle_degeneration1.06723521
86MP0002210_abnormal_sex_determination1.06242036
87MP0000747_muscle_weakness1.05990714
88MP0006054_spinal_hemorrhage1.05307465
89MP0004134_abnormal_chest_morphology1.04953719
90MP0001348_abnormal_lacrimal_gland1.03817890
91MP0001915_intracranial_hemorrhage1.03541949
92MP0001835_abnormal_antigen_presentation1.02856227
93MP0005023_abnormal_wound_healing0.98745958
94MP0004215_abnormal_myocardial_fiber0.97697194
95MP0002429_abnormal_blood_cell0.95607917
96MP0005174_abnormal_tail_pigmentation0.95454077
97MP0001853_heart_inflammation0.94916674
98MP0002925_abnormal_cardiovascular_devel0.94739483
99MP0000750_abnormal_muscle_regeneration0.94370206
100MP0009333_abnormal_splenocyte_physiolog0.94334059
101MP0000465_gastrointestinal_hemorrhage0.94114230
102MP0002877_abnormal_melanocyte_morpholog0.93892971
103MP0000015_abnormal_ear_pigmentation0.92268777
104MP0000733_abnormal_muscle_development0.92039687
105MP0000266_abnormal_heart_morphology0.91820909
106MP0002697_abnormal_eye_size0.91787928
107MP0002837_dystrophic_cardiac_calcinosis0.91147491
108MP0001145_abnormal_male_reproductive0.90676126
109MP0005464_abnormal_platelet_physiology0.90176706
110MP0004085_abnormal_heartbeat0.89836807
111MP0003045_fibrosis0.89774512
112MP0000716_abnormal_immune_system0.89139514
113MP0005408_hypopigmentation0.89129627
114MP0000003_abnormal_adipose_tissue0.88475863
115MP0001544_abnormal_cardiovascular_syste0.87925302
116MP0005385_cardiovascular_system_phenoty0.87925302
117MP0010368_abnormal_lymphatic_system0.87004846
118MP0009703_decreased_birth_body0.86698843
119MP0001929_abnormal_gametogenesis0.86501929
120MP0008775_abnormal_heart_ventricle0.85654717
121MP0001800_abnormal_humoral_immune0.85035326
122MP0003279_aneurysm0.85020956
123MP0004147_increased_porphyrin_level0.84427923
124MP0003091_abnormal_cell_migration0.84336931
125MP0003385_abnormal_body_wall0.84119118
126MP0002405_respiratory_system_inflammati0.84035371
127MP0000383_abnormal_hair_follicle0.83806731
128MP0005621_abnormal_cell_physiology0.82706100
129MP0002006_tumorigenesis0.81600352
130MP0003121_genomic_imprinting0.81490769
131MP0002127_abnormal_cardiovascular_syste0.81027221
132MP0002452_abnormal_antigen_presenting0.80904481
133MP0003941_abnormal_skin_development0.80734659
134MP0003942_abnormal_urinary_system0.80677777
135MP0002106_abnormal_muscle_physiology0.80474499
136MP0002168_other_aberrant_phenotype0.80091053
137MP0000428_abnormal_craniofacial_morphol0.79516327
138MP0009672_abnormal_birth_weight0.79443357
139MP0003300_gastrointestinal_ulcer0.77802854
140MP0010678_abnormal_skin_adnexa0.77635384
141MP0002128_abnormal_blood_circulation0.77588031
142MP0005666_abnormal_adipose_tissue0.77388037
143MP0005384_cellular_phenotype0.76735813
144MP0000372_irregular_coat_pigmentation0.76703084
145MP0002420_abnormal_adaptive_immunity0.76256096
146MP0000343_altered_response_to0.75476380
147MP0000371_diluted_coat_color0.75338703
148MP0000534_abnormal_ureter_morphology0.74740036
149MP0001819_abnormal_immune_cell0.74726784
150MP0002075_abnormal_coat/hair_pigmentati0.74110378
151MP0004233_abnormal_muscle_weight0.73940136
152MP0002114_abnormal_axial_skeleton0.73344157
153MP0000013_abnormal_adipose_tissue0.70926821
154MP0009046_muscle_twitch0.68386040

Predicted human phenotypes

RankGene SetZ-score
1Pheochromocytoma (HP:0002666)3.88613394
2Dysmetric saccades (HP:0000641)3.71563951
3Macroorchidism (HP:0000053)3.57365815
4Chromsome breakage (HP:0040012)3.40257406
5Ependymoma (HP:0002888)3.25711553
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.12695082
7Vertebral arch anomaly (HP:0008438)3.12227765
8Abnormality of the fingertips (HP:0001211)3.07805034
9Neuroendocrine neoplasm (HP:0100634)2.99997733
10Selective tooth agenesis (HP:0001592)2.91479081
11Asymmetric septal hypertrophy (HP:0001670)2.86597023
12Submucous cleft hard palate (HP:0000176)2.77295091
13Thrombocytosis (HP:0001894)2.72976583
14High pitched voice (HP:0001620)2.72369243
15Prominent nose (HP:0000448)2.66022760
16Papillary thyroid carcinoma (HP:0002895)2.65884199
17Ankle contracture (HP:0006466)2.65081764
18Abnormality of chromosome stability (HP:0003220)2.64908390
19Overgrowth (HP:0001548)2.64482519
20Protruding tongue (HP:0010808)2.63067329
21Abnormality of chromosome segregation (HP:0002916)2.60856178
22Agnosia (HP:0010524)2.60506387
23Reticulocytopenia (HP:0001896)2.59706315
24Colon cancer (HP:0003003)2.57260299
25Myelodysplasia (HP:0002863)2.53120186
2611 pairs of ribs (HP:0000878)2.52126240
27Birth length less than 3rd percentile (HP:0003561)2.52111053
28Hyperventilation (HP:0002883)2.50552381
29Increased connective tissue (HP:0009025)2.50390075
30Ventricular tachycardia (HP:0004756)2.50132786
31Calf muscle hypertrophy (HP:0008981)2.48695796
32Heterotopia (HP:0002282)2.46994846
33Long eyelashes (HP:0000527)2.42321387
34Volvulus (HP:0002580)2.40147044
35Cerebral aneurysm (HP:0004944)2.39862220
36Subaortic stenosis (HP:0001682)2.39155201
37Abnormality of the left ventricular outflow tract (HP:0011103)2.39155201
38Impulsivity (HP:0100710)2.38672937
39Medulloblastoma (HP:0002885)2.38391546
40Urethral obstruction (HP:0000796)2.38001471
41Midline defect of the nose (HP:0004122)2.36393037
42Metaphyseal cupping (HP:0003021)2.33104422
43IgM deficiency (HP:0002850)2.31787539
44Fair hair (HP:0002286)2.31555419
45Blue irides (HP:0000635)2.27093310
46Exotropia (HP:0000577)2.26350661
47Ankyloglossia (HP:0010296)2.25848710
48Abnormal spermatogenesis (HP:0008669)2.25224802
49Astrocytoma (HP:0009592)2.25131356
50Abnormality of the astrocytes (HP:0100707)2.25131356
51Muscle hypertrophy of the lower extremities (HP:0008968)2.22603900
52Relative macrocephaly (HP:0004482)2.19141707
53Cubitus valgus (HP:0002967)2.17812705
54Ectopic kidney (HP:0000086)2.17120900
55Sandal gap (HP:0001852)2.17096376
56Drooling (HP:0002307)2.15485494
57Acute myeloid leukemia (HP:0004808)2.13221204
58Papilledema (HP:0001085)2.11589253
59Neoplasm of the peripheral nervous system (HP:0100007)2.11120376
60Recurrent viral infections (HP:0004429)2.10898173
61Febrile seizures (HP:0002373)2.10558359
62Truncal obesity (HP:0001956)2.10387497
63Absent thumb (HP:0009777)2.08956788
64Lipoatrophy (HP:0100578)2.07966951
65Short 4th metacarpal (HP:0010044)2.06422454
66Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06422454
67Basal cell carcinoma (HP:0002671)2.05796227
68Spinal muscular atrophy (HP:0007269)2.05391273
69Abnormality of the calf musculature (HP:0001430)2.04885813
70Deviation of the thumb (HP:0009603)2.04336804
71Neoplasm of the oral cavity (HP:0100649)2.04237674
72Increased nuchal translucency (HP:0010880)2.03548584
73Asymmetry of the thorax (HP:0001555)2.02514481
74Abnormality of the anterior horn cell (HP:0006802)2.02233748
75Degeneration of anterior horn cells (HP:0002398)2.02233748
76Mitral valve prolapse (HP:0001634)2.01558529
77Meckel diverticulum (HP:0002245)2.01263835
78Missing ribs (HP:0000921)2.01020014
79Exercise-induced muscle cramps (HP:0003710)2.00894895
80Cafe-au-lait spot (HP:0000957)2.00374812
81Thick eyebrow (HP:0000574)2.00344260
82Narrow palate (HP:0000189)2.00157755
83Bicuspid aortic valve (HP:0001647)1.99963694
84Bundle branch block (HP:0011710)1.99594777
85Proximal placement of thumb (HP:0009623)1.99452809
86Nephroblastoma (Wilms tumor) (HP:0002667)1.99320590
87Abnormality of the ischium (HP:0003174)1.99161893
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.98903846
89Petechiae (HP:0000967)1.98807688
90Sudden death (HP:0001699)1.98263595
91Aplastic anemia (HP:0001915)1.97601575
92Deep philtrum (HP:0002002)1.96256483
93Azoospermia (HP:0000027)1.95375151
94Gaze-evoked nystagmus (HP:0000640)1.95315403
95Cutaneous melanoma (HP:0012056)1.93762583
96Abnormality of the ileum (HP:0001549)1.93648505
97Glioma (HP:0009733)1.93427829
98Embryonal renal neoplasm (HP:0011794)1.93384880
99Hyporeflexia of lower limbs (HP:0002600)1.92767154
100Nemaline bodies (HP:0003798)1.92715099
101Facial diplegia (HP:0001349)1.90584253
102Biliary tract neoplasm (HP:0100574)1.90091067
103Short chin (HP:0000331)1.89215220
104Excessive salivation (HP:0003781)1.88821501
105Generalized hypopigmentation of hair (HP:0011358)1.88646038
106Abnormality of DNA repair (HP:0003254)1.88619103
107Obsessive-compulsive behavior (HP:0000722)1.88443451
108Abnormality of the preputium (HP:0100587)1.87594896
109Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.87031255
110Duodenal stenosis (HP:0100867)1.85654203
111Small intestinal stenosis (HP:0012848)1.85654203
112Conjunctival telangiectasia (HP:0000524)1.85530367
113Muscle fiber inclusion bodies (HP:0100299)1.85206641
114Rhabdomyosarcoma (HP:0002859)1.84941173
115Large earlobe (HP:0009748)1.83659616
116Deeply set eye (HP:0000490)1.83495273
117Hypoplasia of the iris (HP:0007676)1.82615112
118Atrial fibrillation (HP:0005110)1.82460606
119Amaurosis fugax (HP:0100576)1.82317259
120Low anterior hairline (HP:0000294)1.81724476
121Arterial tortuosity (HP:0005116)1.81032839
122Duplicated collecting system (HP:0000081)1.79773016
123Slender long bone (HP:0003100)1.77931401
124Sloping forehead (HP:0000340)1.77500645
125Rhabdomyolysis (HP:0003201)1.76725349
126Bowel incontinence (HP:0002607)1.76475264
127Mild short stature (HP:0003502)1.76298649
128Germ cell neoplasia (HP:0100728)1.75795037
129Neoplasm of the small intestine (HP:0100833)1.75735454
130Bone marrow hypocellularity (HP:0005528)1.75294891
131Tracheomalacia (HP:0002779)1.74168222
132Menstrual irregularities (HP:0000858)1.73849889
133Hematochezia (HP:0002573)1.73776784
134Broad palm (HP:0001169)1.73724557
135Entropion (HP:0000621)1.73230546
136Neoplasm of the rectum (HP:0100743)1.73128754
137Poikiloderma (HP:0001029)1.72335508
138Abnormality of the 4th metacarpal (HP:0010012)1.71565085
139Muscle fiber splitting (HP:0003555)1.71322532
140Neoplasm of striated muscle (HP:0009728)1.70893559
141Broad ribs (HP:0000885)1.69468803
142Ovarian neoplasm (HP:0100615)1.67896524
143Supraventricular tachycardia (HP:0004755)1.67444026
144Gastrointestinal carcinoma (HP:0002672)1.67190975
145Malignant gastrointestinal tract tumors (HP:0006749)1.67190975
146Right ventricular cardiomyopathy (HP:0011663)1.67125255
147Supraventricular arrhythmia (HP:0005115)1.67115197
148Tapered finger (HP:0001182)1.66417000
149Neoplasm of the colon (HP:0100273)1.66019587
150Skull defect (HP:0001362)1.65516522
151Muscle fibrillation (HP:0010546)1.65225543
152Abnormality of the carotid arteries (HP:0005344)1.65066048
153Abnormality of the calcaneus (HP:0008364)1.64926443
154Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.64692736
155Cystic hygroma (HP:0000476)1.64222290
156Underdeveloped nasal alae (HP:0000430)1.63724289
157Primary atrial arrhythmia (HP:0001692)1.63505769
158Increased density of long bones (HP:0006392)1.62668873
159Open mouth (HP:0000194)1.62397100
160Abnormality of the nasal septum (HP:0000419)1.61848391
161Septate vagina (HP:0001153)1.61709302
162Aortic aneurysm (HP:0004942)1.61549853
163Hyperacusis (HP:0010780)1.61204923
164Gonadotropin excess (HP:0000837)1.60902566
165Abnormality of the renal collecting system (HP:0004742)1.60605041
166Lymphoma (HP:0002665)1.60097516
167Patellar aplasia (HP:0006443)1.59708647
168Osteolytic defects of the hand bones (HP:0009699)1.58915439
169Abnormal large intestine physiology (HP:0012700)1.58672975
170Exercise-induced myalgia (HP:0003738)1.57792961
171Partial agenesis of the corpus callosum (HP:0001338)1.56733282
172Steppage gait (HP:0003376)1.56648833
173Arteriovenous malformation (HP:0100026)1.55807057
174Widely spaced teeth (HP:0000687)1.55519294
175Thyroid carcinoma (HP:0002890)1.55474566
176Hypoplasia of the maxilla (HP:0000327)1.54652072
177Impaired social interactions (HP:0000735)1.54607317

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS24.25272409
2CDK123.96053792
3CDC73.82565551
4EEF2K3.02425052
5AKT32.73651561
6TTN2.62715449
7WEE12.58146005
8PKN22.50481885
9FRK2.45985662
10NEK22.38777253
11NEK12.04839130
12STK102.02106229
13TTK1.94379402
14TRIB31.90430378
15MAP3K101.86123145
16BUB11.85858211
17ACVR1B1.84824566
18TSSK61.84587721
19TGFBR21.78617843
20RPS6KB21.77045637
21ATR1.73001432
22CDK41.59459067
23ICK1.51038970
24STK41.50294613
25BRD41.49703611
26FGFR31.49014253
27PNCK1.48596647
28NTRK31.48288087
29WNK11.44336033
30NLK1.44154625
31PDK31.43198242
32PDK41.43198242
33CSF1R1.42279425
34TGFBR11.41488989
35PLK11.41081741
36MAP4K11.37744653
37PIK3CA1.37605395
38TAF11.36709950
39FLT31.36128728
40CDK71.33109346
41MAP3K71.32264452
42BRSK21.29592091
43MAP2K31.29547859
44PDGFRA1.29460571
45PASK1.28933766
46SGK21.27026609
47SRPK11.20290405
48CLK11.19629939
49PAK41.19607477
50AURKB1.18680379
51CAMK1D1.17529025
52CHEK11.16433039
53SCYL21.13027458
54CDK61.12519435
55STK31.11397419
56STK241.09876047
57RPS6KA41.09794717
58CHEK21.09217274
59MTOR1.08937986
60PIM11.07954713
61CASK1.05529842
62ZAK1.04169882
63CCNB11.03911404
64MKNK11.01627692
65ATM1.00624085
66MAP3K80.99437110
67TNIK0.96960705
68TYK20.95212230
69RET0.93739494
70FGFR20.92889908
71CAMK40.92716910
72MAP3K130.91088382
73MAP3K90.90461354
74PLK40.89626251
75PRKAA20.88850675
76SGK30.87256035
77MAPK110.85822256
78FGFR10.83599299
79ALK0.82406068
80KIT0.82355731
81BTK0.79781701
82DMPK0.79437891
83PINK10.79192402
84CDK20.78248351
85EIF2AK10.76910580
86MAPKAPK50.74831704
87TRPM70.73456817
88BMX0.72187300
89LRRK20.71137242
90RPS6KB10.70778556
91SGK10.70759430
92PRKAA10.70574128
93MAPK100.69181911
94PLK30.67339968
95OBSCN0.67016564
96FGFR40.67015481
97RIPK10.66808181
98NME20.66709381
99MAP3K20.66198095
100MAPK120.65558037
101VRK10.63860175
102MAP3K30.63400559
103PDK20.62514063
104MKNK20.62219694
105LMTK20.61172116
106PTK60.60655542
107LATS10.59978282
108PAK20.59827577
109TEC0.57087151
110CDK10.56751490
111STK110.56568601
112TLK10.56174719
113CAMK10.55115744
114SIK20.54807622
115MAPKAPK30.54301676
116MELK0.51856070
117STK390.51766594
118SGK2230.51677052
119SGK4940.51677052
120CAMKK20.51156727
121NTRK20.50671082
122CSNK1E0.49816239
123DYRK30.49613452
124MARK10.49509847
125CHUK0.49136809
126MAPK140.48992473
127ZAP700.48770916
128CSNK1D0.48197781
129RPS6KC10.47663033
130RPS6KL10.47663033
131AKT20.47397761
132CDK30.47278241
133MAP3K60.46820711
134GSK3B0.46634004
135EPHA30.45950558
136RPS6KA60.45159004
137JAK30.45072121
138MYLK0.44638612
139NEK90.44337562
140PDGFRB0.43316894
141RPS6KA30.42545956
142PRKDC0.41795478
143ILK0.41540935
144GRK60.41235245
145CAMK1G0.41012073
146TAOK30.40794534
147CSNK2A20.40458969
148JAK10.40297600
149FER0.39909970
150STK38L0.38874732
151MET0.38493435
152GRK70.37807813
153PAK30.37746862
154ITK0.37666873
155EIF2AK30.36734387
156BRSK10.36245251
157CDK90.35180287

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.12208476
2Mismatch repair_Homo sapiens_hsa034303.53756987
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.95716064
4Base excision repair_Homo sapiens_hsa034102.82704214
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.77614452
6RNA transport_Homo sapiens_hsa030132.60989441
7Cell cycle_Homo sapiens_hsa041102.50350158
8Non-homologous end-joining_Homo sapiens_hsa034502.46980354
9Homologous recombination_Homo sapiens_hsa034402.43418445
10Spliceosome_Homo sapiens_hsa030402.40347799
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21785893
12Nucleotide excision repair_Homo sapiens_hsa034202.09049249
13Dorso-ventral axis formation_Homo sapiens_hsa043202.06091191
14* One carbon pool by folate_Homo sapiens_hsa006702.01237977
15Long-term potentiation_Homo sapiens_hsa047201.92037346
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.85235657
17Fanconi anemia pathway_Homo sapiens_hsa034601.84087618
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.83470755
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79131309
20cGMP-PKG signaling pathway_Homo sapiens_hsa040221.74082796
21mRNA surveillance pathway_Homo sapiens_hsa030151.65842220
22RNA degradation_Homo sapiens_hsa030181.63981934
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60200929
24Glioma_Homo sapiens_hsa052141.55619160
25Antigen processing and presentation_Homo sapiens_hsa046121.49283638
26Lysine degradation_Homo sapiens_hsa003101.48976954
27Circadian rhythm_Homo sapiens_hsa047101.47022225
28Nicotine addiction_Homo sapiens_hsa050331.45520005
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44393488
30p53 signaling pathway_Homo sapiens_hsa041151.40484388
31Thyroid hormone synthesis_Homo sapiens_hsa049181.38985796
32RNA polymerase_Homo sapiens_hsa030201.38162435
33Longevity regulating pathway - mammal_Homo sapiens_hsa042111.36111295
34Basal transcription factors_Homo sapiens_hsa030221.32860934
35Pyrimidine metabolism_Homo sapiens_hsa002401.29225840
36Herpes simplex infection_Homo sapiens_hsa051681.28333414
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26231402
38Prostate cancer_Homo sapiens_hsa052151.24190694
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23700845
40Small cell lung cancer_Homo sapiens_hsa052221.23176643
41Endometrial cancer_Homo sapiens_hsa052131.21247845
42Viral carcinogenesis_Homo sapiens_hsa052031.20232549
43Glucagon signaling pathway_Homo sapiens_hsa049221.18898444
44Renin secretion_Homo sapiens_hsa049241.16985705
45Amphetamine addiction_Homo sapiens_hsa050311.16791949
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15165133
47Systemic lupus erythematosus_Homo sapiens_hsa053221.14875632
48Viral myocarditis_Homo sapiens_hsa054161.13399292
49Ribosome_Homo sapiens_hsa030101.12330739
50Epstein-Barr virus infection_Homo sapiens_hsa051691.11908635
51Gastric acid secretion_Homo sapiens_hsa049711.11540097
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.09929450
53Oxytocin signaling pathway_Homo sapiens_hsa049211.06345348
54Carbon metabolism_Homo sapiens_hsa012001.05757119
55Type II diabetes mellitus_Homo sapiens_hsa049301.05051559
56Renal cell carcinoma_Homo sapiens_hsa052111.04232467
57ECM-receptor interaction_Homo sapiens_hsa045121.04098872
58HTLV-I infection_Homo sapiens_hsa051661.03608971
59Insulin secretion_Homo sapiens_hsa049111.02471560
60Calcium signaling pathway_Homo sapiens_hsa040201.02357828
61Proteasome_Homo sapiens_hsa030501.00809344
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00754559
63Circadian entrainment_Homo sapiens_hsa047131.00505826
64ErbB signaling pathway_Homo sapiens_hsa040120.99196567
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99116776
66Salivary secretion_Homo sapiens_hsa049700.98569251
67Estrogen signaling pathway_Homo sapiens_hsa049150.97563359
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97340037
69Primary immunodeficiency_Homo sapiens_hsa053400.95917119
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94735641
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.92906639
72Legionellosis_Homo sapiens_hsa051340.92744011
73MicroRNAs in cancer_Homo sapiens_hsa052060.89413119
74Inositol phosphate metabolism_Homo sapiens_hsa005620.89133315
75Chronic myeloid leukemia_Homo sapiens_hsa052200.88870509
76Pancreatic secretion_Homo sapiens_hsa049720.88532970
77Pentose phosphate pathway_Homo sapiens_hsa000300.88281012
78cAMP signaling pathway_Homo sapiens_hsa040240.87966185
79Notch signaling pathway_Homo sapiens_hsa043300.86856682
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.86815363
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85257303
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82930445
83Hippo signaling pathway_Homo sapiens_hsa043900.82291182
84AMPK signaling pathway_Homo sapiens_hsa041520.82244237
85Melanoma_Homo sapiens_hsa052180.81079691
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.80678646
87Protein digestion and absorption_Homo sapiens_hsa049740.80450544
88Choline metabolism in cancer_Homo sapiens_hsa052310.80172370
89Apoptosis_Homo sapiens_hsa042100.79767302
90Fructose and mannose metabolism_Homo sapiens_hsa000510.78478033
91ABC transporters_Homo sapiens_hsa020100.78195054
92Measles_Homo sapiens_hsa051620.78191774
93* Biosynthesis of amino acids_Homo sapiens_hsa012300.77825374
94Cocaine addiction_Homo sapiens_hsa050300.77078202
95HIF-1 signaling pathway_Homo sapiens_hsa040660.75782955
96Alcoholism_Homo sapiens_hsa050340.75684694
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74323546
98Prolactin signaling pathway_Homo sapiens_hsa049170.74250162
99Acute myeloid leukemia_Homo sapiens_hsa052210.73415372
100mTOR signaling pathway_Homo sapiens_hsa041500.72253565
101* Selenocompound metabolism_Homo sapiens_hsa004500.71683886
102Adherens junction_Homo sapiens_hsa045200.71401132
103Dopaminergic synapse_Homo sapiens_hsa047280.71085942
104B cell receptor signaling pathway_Homo sapiens_hsa046620.70799902
105Other glycan degradation_Homo sapiens_hsa005110.70473860
106Taste transduction_Homo sapiens_hsa047420.70240665
107Leishmaniasis_Homo sapiens_hsa051400.70191974
108Long-term depression_Homo sapiens_hsa047300.69959995
109Mineral absorption_Homo sapiens_hsa049780.69497650
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68993569
111GnRH signaling pathway_Homo sapiens_hsa049120.68856394
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68787904
113Glutamatergic synapse_Homo sapiens_hsa047240.68556606
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.68139891
115Oocyte meiosis_Homo sapiens_hsa041140.68114364
116Wnt signaling pathway_Homo sapiens_hsa043100.66476980
117Influenza A_Homo sapiens_hsa051640.66314189
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.65877804
119Toxoplasmosis_Homo sapiens_hsa051450.65780891
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65298109
121Melanogenesis_Homo sapiens_hsa049160.65264556
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.64512899
123Thyroid cancer_Homo sapiens_hsa052160.64275459
124Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63321706
125Hepatitis B_Homo sapiens_hsa051610.62521066
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61596574
127Morphine addiction_Homo sapiens_hsa050320.60726607
128Dilated cardiomyopathy_Homo sapiens_hsa054140.60124249
129Galactose metabolism_Homo sapiens_hsa000520.60055512
130Olfactory transduction_Homo sapiens_hsa047400.60027819
131Renin-angiotensin system_Homo sapiens_hsa046140.59997368
132Cholinergic synapse_Homo sapiens_hsa047250.59365432
133Ovarian steroidogenesis_Homo sapiens_hsa049130.58938985
134Gap junction_Homo sapiens_hsa045400.57934695
135Tight junction_Homo sapiens_hsa045300.57268130
136Purine metabolism_Homo sapiens_hsa002300.57110175
137Osteoclast differentiation_Homo sapiens_hsa043800.56916120
138Non-small cell lung cancer_Homo sapiens_hsa052230.53286919
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51789587
140Insulin resistance_Homo sapiens_hsa049310.51757459
141Hematopoietic cell lineage_Homo sapiens_hsa046400.51705085
142Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51519024
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51420081
144Colorectal cancer_Homo sapiens_hsa052100.48001894
145Platelet activation_Homo sapiens_hsa046110.47965069
146Focal adhesion_Homo sapiens_hsa045100.47241206
147Pancreatic cancer_Homo sapiens_hsa052120.43807690
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40396053
149Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40149754
150Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39542093
151Insulin signaling pathway_Homo sapiens_hsa049100.39480908
152Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39354423
153TGF-beta signaling pathway_Homo sapiens_hsa043500.38924628
154Drug metabolism - other enzymes_Homo sapiens_hsa009830.38786611
155* Cysteine and methionine metabolism_Homo sapiens_hsa002700.38261494
156Proteoglycans in cancer_Homo sapiens_hsa052050.38157433
157Pathways in cancer_Homo sapiens_hsa052000.36891794
158Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36441420
159FoxO signaling pathway_Homo sapiens_hsa040680.34837501
160Caffeine metabolism_Homo sapiens_hsa002320.34791421
161Jak-STAT signaling pathway_Homo sapiens_hsa046300.34615165
162Fatty acid degradation_Homo sapiens_hsa000710.33315731
163Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30918562
164Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29977751

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