MTRF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene was determined by in silico methods to be a mitochondrial protein with similarity to the peptide chain release factors (RFs) discovered in bacteria and yeast. The peptide chain release factors direct the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis, a recent publication found no mitochondrial translation release functionality. Multiple alternatively spliced transcript variants have been suggested by mRNA and EST data; however, their full-length natures are not clear. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of meiosis I (GO:0060631)5.14691351
2behavioral response to nicotine (GO:0035095)4.95577439
3DNA double-strand break processing (GO:0000729)4.88682728
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.52155412
5ribosomal small subunit assembly (GO:0000028)4.27232517
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.21689516
7ATP synthesis coupled proton transport (GO:0015986)4.21689516
8oxidative phosphorylation (GO:0006119)4.15148248
9protein localization to cilium (GO:0061512)3.99181943
10maturation of SSU-rRNA (GO:0030490)3.90084311
11centriole replication (GO:0007099)3.71596406
12neural tube formation (GO:0001841)3.71583276
13aldehyde catabolic process (GO:0046185)3.68561500
14purine nucleobase biosynthetic process (GO:0009113)3.63824832
15IMP metabolic process (GO:0046040)3.63209292
16DNA catabolic process, exonucleolytic (GO:0000738)3.56410334
17piRNA metabolic process (GO:0034587)3.53291591
18recombinational repair (GO:0000725)3.53226770
19double-strand break repair via homologous recombination (GO:0000724)3.52482571
20L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.51429711
21inner mitochondrial membrane organization (GO:0007007)3.45533836
22DNA replication initiation (GO:0006270)3.42464418
23fucose catabolic process (GO:0019317)3.42461163
24L-fucose metabolic process (GO:0042354)3.42461163
25L-fucose catabolic process (GO:0042355)3.42461163
26rRNA modification (GO:0000154)3.41024839
27IMP biosynthetic process (GO:0006188)3.39835224
28DNA strand elongation involved in DNA replication (GO:0006271)3.39097353
29protein neddylation (GO:0045116)3.37206087
30folic acid-containing compound biosynthetic process (GO:0009396)3.34860260
31nucleobase biosynthetic process (GO:0046112)3.34483296
32replication fork processing (GO:0031297)3.33947810
33tricarboxylic acid cycle (GO:0006099)3.33478046
34L-methionine salvage (GO:0071267)3.33362798
35L-methionine biosynthetic process (GO:0071265)3.33362798
36amino acid salvage (GO:0043102)3.33362798
37adaptation of signaling pathway (GO:0023058)3.31930226
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31796572
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.31796572
40NADH dehydrogenase complex assembly (GO:0010257)3.31796572
41establishment of protein localization to mitochondrial membrane (GO:0090151)3.30440080
42proteasome assembly (GO:0043248)3.29709871
43DNA methylation involved in gamete generation (GO:0043046)3.28687354
44pteridine-containing compound biosynthetic process (GO:0042559)3.26443573
45telomere maintenance via semi-conservative replication (GO:0032201)3.25121549
46negative regulation of DNA-dependent DNA replication (GO:2000104)3.24082562
47homocysteine metabolic process (GO:0050667)3.24041010
48regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.23838427
49regulation of mitotic spindle checkpoint (GO:1903504)3.23838427
50DNA strand elongation (GO:0022616)3.21382665
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.21143317
52protein K6-linked ubiquitination (GO:0085020)3.18933269
53DNA deamination (GO:0045006)3.17686062
54respiratory electron transport chain (GO:0022904)3.16208325
55fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.16089945
56chromatin remodeling at centromere (GO:0031055)3.13944009
57prenylation (GO:0097354)3.13275424
58protein prenylation (GO:0018342)3.13275424
59rRNA methylation (GO:0031167)3.13252790
60meiotic chromosome segregation (GO:0045132)3.12058136
61electron transport chain (GO:0022900)3.11744457
62protein complex biogenesis (GO:0070271)3.11056454
63DNA replication checkpoint (GO:0000076)3.09545345
64detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.09229845
65platelet dense granule organization (GO:0060155)3.07244011
66chaperone-mediated protein transport (GO:0072321)3.07138051
67nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05976277
68positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03915118
69oxaloacetate metabolic process (GO:0006107)3.03581286
70regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.03246320
71regulation of cellular amino acid metabolic process (GO:0006521)3.02529025
72behavioral response to ethanol (GO:0048149)3.01919174
73ether lipid metabolic process (GO:0046485)3.00263265
74methionine metabolic process (GO:0006555)2.99805980
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99659702
76reciprocal DNA recombination (GO:0035825)2.98692949
77reciprocal meiotic recombination (GO:0007131)2.98692949
78mitochondrial respiratory chain complex assembly (GO:0033108)2.97558295
79cullin deneddylation (GO:0010388)2.96508555
80mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.95726363
81aspartate family amino acid biosynthetic process (GO:0009067)2.95563446
82negative regulation of ligase activity (GO:0051352)2.94567113
83negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94567113
84antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.94025957
85protein deneddylation (GO:0000338)2.93152104
86intraciliary transport (GO:0042073)2.92415179
87cellular respiration (GO:0045333)2.91899691
88anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91765712
89RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90492886
90transcription elongation from RNA polymerase I promoter (GO:0006362)2.89689200
91pseudouridine synthesis (GO:0001522)2.87384682
92cytochrome complex assembly (GO:0017004)2.86815120
93organelle disassembly (GO:1903008)2.86396202
94DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.86031997
95somite rostral/caudal axis specification (GO:0032525)2.85787285
96telomere maintenance via recombination (GO:0000722)2.85654043
97water-soluble vitamin biosynthetic process (GO:0042364)2.85291320
98protein-cofactor linkage (GO:0018065)2.85214719
99methionine biosynthetic process (GO:0009086)2.85196901
100postreplication repair (GO:0006301)2.84169272
101aerobic respiration (GO:0009060)2.83211498
102intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.83043476
103signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.83043476
104DNA unwinding involved in DNA replication (GO:0006268)2.81856137
105ubiquinone biosynthetic process (GO:0006744)2.81190078
106quinone biosynthetic process (GO:1901663)2.81190078
107maturation of 5.8S rRNA (GO:0000460)2.80058842
108erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.78486192
109L-phenylalanine metabolic process (GO:0006558)2.78486192
110ribosomal large subunit biogenesis (GO:0042273)2.78234579
111signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.77525023
112signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.77525023
113signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.77525023
114tetrahydrofolate metabolic process (GO:0046653)2.77159622
115antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.74747093
116glyoxylate metabolic process (GO:0046487)2.74430263
117tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.72849782
118RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.72849782
119aspartate family amino acid metabolic process (GO:0009066)2.72288933
120glycine metabolic process (GO:0006544)2.72121120
1217-methylguanosine mRNA capping (GO:0006370)2.71065179
122somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70659677
123somatic hypermutation of immunoglobulin genes (GO:0016446)2.70659677
124signal transduction involved in DNA damage checkpoint (GO:0072422)2.70557156
125signal transduction involved in DNA integrity checkpoint (GO:0072401)2.70557156
126respiratory chain complex IV assembly (GO:0008535)2.70349335
127folic acid metabolic process (GO:0046655)2.70149208
128sulfur amino acid biosynthetic process (GO:0000097)2.69735992
129DNA demethylation (GO:0080111)2.69116621
130synapsis (GO:0007129)2.68876112
131serine family amino acid biosynthetic process (GO:0009070)2.68644640
132sulfur amino acid metabolic process (GO:0000096)2.68337998
133mitotic recombination (GO:0006312)2.67238484
134signal transduction involved in cell cycle checkpoint (GO:0072395)2.66642695
135positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.66133202
136positive regulation of meiosis (GO:0045836)2.66061880
137indolalkylamine metabolic process (GO:0006586)2.66038262
138regulation of hexokinase activity (GO:1903299)2.65836210
139regulation of glucokinase activity (GO:0033131)2.65836210
140viral mRNA export from host cell nucleus (GO:0046784)2.64799127
141regulation of centriole replication (GO:0046599)2.64444616
142regulation of nuclear cell cycle DNA replication (GO:0033262)2.64231249
143necroptotic process (GO:0070266)2.64194200
1447-methylguanosine RNA capping (GO:0009452)2.63389591
145RNA capping (GO:0036260)2.63389591
146bile acid biosynthetic process (GO:0006699)2.63369307
147attachment of spindle microtubules to kinetochore (GO:0008608)2.63211106
148erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.63194928
149nonmotile primary cilium assembly (GO:0035058)2.62748898
150branched-chain amino acid catabolic process (GO:0009083)2.62281111
151tRNA processing (GO:0008033)2.61245570
152DNA-dependent DNA replication (GO:0006261)2.60963013
153indole-containing compound catabolic process (GO:0042436)2.60540227
154indolalkylamine catabolic process (GO:0046218)2.60540227
155tryptophan catabolic process (GO:0006569)2.60540227
156adenosine metabolic process (GO:0046085)2.60052523
157male meiosis I (GO:0007141)2.59494559
158CENP-A containing nucleosome assembly (GO:0034080)2.58905084
159ubiquinone metabolic process (GO:0006743)2.58812839
160regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.58335757
161detection of light stimulus involved in visual perception (GO:0050908)2.56081040
162detection of light stimulus involved in sensory perception (GO:0050962)2.56081040
163male meiosis (GO:0007140)2.55952004
164maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.55610648
165negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.55437621
166centriole assembly (GO:0098534)2.52517093
167kidney morphogenesis (GO:0060993)2.51654405
168regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.51178434
169mismatch repair (GO:0006298)2.49066123
170negative regulation of translation, ncRNA-mediated (GO:0040033)2.48765428
171regulation of translation, ncRNA-mediated (GO:0045974)2.48765428
172negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.48765428
173positive regulation of meiotic cell cycle (GO:0051446)2.48222065
174response to pheromone (GO:0019236)2.47812346
175cytidine metabolic process (GO:0046087)2.46951253
176cytidine catabolic process (GO:0006216)2.46951253
177cytidine deamination (GO:0009972)2.46951253
178sulfation (GO:0051923)2.46863444
179DNA damage response, detection of DNA damage (GO:0042769)2.46568461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.59480907
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.39697171
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.11026848
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.66821809
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.59210269
6* GABP_17652178_ChIP-ChIP_JURKAT_Human3.51118248
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.45144460
8ZNF274_21170338_ChIP-Seq_K562_Hela3.38558831
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.32552892
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.96735337
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.85246041
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78501449
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.75264891
14VDR_22108803_ChIP-Seq_LS180_Human2.73526593
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.71103373
16IGF1R_20145208_ChIP-Seq_DFB_Human2.70474217
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.68145286
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.66779797
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64569722
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62338992
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60417213
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57276999
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55514919
24* SRF_21415370_ChIP-Seq_HL-1_Mouse2.49042834
25* VDR_23849224_ChIP-Seq_CD4+_Human2.47607100
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.46106934
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.40210032
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36461356
29ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31650222
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.27545191
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.23200977
32* FOXP3_21729870_ChIP-Seq_TREG_Human2.21975246
33EWS_26573619_Chip-Seq_HEK293_Human2.21719737
34MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20403358
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18584417
36* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.17568427
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.17004860
38HOXB4_20404135_ChIP-ChIP_EML_Mouse2.15575927
39GBX2_23144817_ChIP-Seq_PC3_Human2.15330429
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11236767
41DCP1A_22483619_ChIP-Seq_HELA_Human2.10699037
42NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06142007
43PCGF2_27294783_Chip-Seq_ESCs_Mouse2.05398784
44RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05308815
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03687345
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02802499
47ELK1_19687146_ChIP-ChIP_HELA_Human1.96848870
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96712802
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96580424
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96541395
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93742557
52XRN2_22483619_ChIP-Seq_HELA_Human1.93426709
53P300_19829295_ChIP-Seq_ESCs_Human1.91886726
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87183429
55GABP_19822575_ChIP-Seq_HepG2_Human1.83159728
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.82257197
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79387451
58AR_21909140_ChIP-Seq_LNCAP_Human1.77355165
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75068677
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74937629
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72315371
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68121789
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.67015798
64* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66124051
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64750054
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61902590
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57785315
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56929501
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56340881
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.55580766
71ER_23166858_ChIP-Seq_MCF-7_Human1.52213512
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52148733
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51404875
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51142853
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50697354
76IRF1_19129219_ChIP-ChIP_H3396_Human1.49327299
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48364213
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48302293
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.46097606
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45432569
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.44266052
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42863979
83TTF2_22483619_ChIP-Seq_HELA_Human1.40731428
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40590766
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40128475
86* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40000651
87CBP_20019798_ChIP-Seq_JUKART_Human1.39476849
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39476849
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.37599855
90* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.36741649
91GATA1_22025678_ChIP-Seq_K562_Human1.36536528
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36222393
93BCAT_22108803_ChIP-Seq_LS180_Human1.34806656
94TP53_22573176_ChIP-Seq_HFKS_Human1.34219333
95NANOG_19829295_ChIP-Seq_ESCs_Human1.34199173
96SOX2_19829295_ChIP-Seq_ESCs_Human1.34199173
97MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33883039
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32904656
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31854345
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.31181195
101* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29805256
102MYC_18940864_ChIP-ChIP_HL60_Human1.29653318
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28837246
104FOXM1_23109430_ChIP-Seq_U2OS_Human1.26419991
105STAT3_23295773_ChIP-Seq_U87_Human1.26328846
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26164777
107* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23276287
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.23261139
109RXR_22158963_ChIP-Seq_LIVER_Mouse1.23180297
110PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22093914
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20059176
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18747308
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18621310
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18272580
115SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17706538
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16826891
117* KDM5A_27292631_Chip-Seq_BREAST_Human1.16767040
118TCF4_22108803_ChIP-Seq_LS180_Human1.16602591
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15051592
120TCF4_23295773_ChIP-Seq_U87_Human1.14342687
121AR_25329375_ChIP-Seq_VCAP_Human1.13462625
122FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12028918
123SMAD4_21799915_ChIP-Seq_A2780_Human1.11444256
124PIAS1_25552417_ChIP-Seq_VCAP_Human1.11354165
125NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11132924
126POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10319315
127P53_22387025_ChIP-Seq_ESCs_Mouse1.08959617
128GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08870557
129HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08478527
130ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08459342
131FOXA1_25329375_ChIP-Seq_VCAP_Human1.08132452
132FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08132452
133TFEB_21752829_ChIP-Seq_HELA_Human1.07587997
134NANOG_18555785_Chip-Seq_ESCs_Mouse1.07396010
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07111660
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07104348
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07104348
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05388462
139STAT3_18555785_Chip-Seq_ESCs_Mouse1.05295269
140SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05000083
141STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04997485
142ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03785068
143SMAD3_21741376_ChIP-Seq_EPCs_Human1.03422778
144AR_21572438_ChIP-Seq_LNCaP_Human1.02556729
145TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01791011
146SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01612695
147OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01497763
148SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00958595
149NOTCH1_21737748_ChIP-Seq_TLL_Human1.00632869
150FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00602957
151OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00174479
152P300_18555785_Chip-Seq_ESCs_Mouse0.99238060
153NCOR_22424771_ChIP-Seq_293T_Human0.97856962
154RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97370819
155BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97351145
156GATA3_26560356_Chip-Seq_TH2_Human0.96906158
157E2F1_18555785_Chip-Seq_ESCs_Mouse0.96453537
158* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95342506
159SPI1_23547873_ChIP-Seq_NB4_Human0.94238256
160POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93425139
161TAF15_26573619_Chip-Seq_HEK293_Human0.92200958
162LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91401409
163KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91306827
164IRF8_21731497_ChIP-ChIP_J774_Mouse0.89860845
165CIITA_25753668_ChIP-Seq_RAJI_Human0.85857006
166E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84800393
167IRF8_22096565_ChIP-ChIP_GC-B_Human0.79673780
168GATA2_22383799_ChIP-Seq_G1ME_Mouse0.78605299
169MYB_21317192_ChIP-Seq_ERMYB_Mouse0.77103793
170FUS_26573619_Chip-Seq_HEK293_Human0.74550667
171GATA4_21415370_ChIP-Seq_HL-1_Mouse0.72639271

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.10477476
2MP0002139_abnormal_hepatobiliary_system4.24696787
3MP0005360_urolithiasis3.96033202
4MP0003136_yellow_coat_color3.66565959
5MP0005085_abnormal_gallbladder_physiolo3.28667735
6MP0009697_abnormal_copulation3.25980499
7MP0005365_abnormal_bile_salt3.16634663
8MP0000569_abnormal_digit_pigmentation3.11442709
9MP0008875_abnormal_xenobiotic_pharmacok3.02882465
10MP0006036_abnormal_mitochondrial_physio3.02702360
11MP0004957_abnormal_blastocyst_morpholog2.90525977
12MP0002837_dystrophic_cardiac_calcinosis2.85112440
13MP0003693_abnormal_embryo_hatching2.74706939
14MP0005171_absent_coat_pigmentation2.58833611
15MP0010094_abnormal_chromosome_stability2.53350242
16MP0003646_muscle_fatigue2.50658086
17MP0006035_abnormal_mitochondrial_morpho2.31207424
18MP0001529_abnormal_vocalization2.28090973
19MP0002938_white_spotting2.26725140
20MP0004043_abnormal_pH_regulation2.24498427
21MP0003186_abnormal_redox_activity2.24373601
22MP0006072_abnormal_retinal_apoptosis2.22429138
23MP0000372_irregular_coat_pigmentation2.14099567
24MP0001764_abnormal_homeostasis1.97296626
25MP0005551_abnormal_eye_electrophysiolog1.91158157
26MP0000749_muscle_degeneration1.90967748
27MP0002102_abnormal_ear_morphology1.88942124
28MP0002653_abnormal_ependyma_morphology1.81802299
29MP0005332_abnormal_amino_acid1.80644047
30MP0009379_abnormal_foot_pigmentation1.78091618
31MP0004084_abnormal_cardiac_muscle1.71955636
32MP0003656_abnormal_erythrocyte_physiolo1.69511260
33MP0010329_abnormal_lipoprotein_level1.67121346
34MP0003077_abnormal_cell_cycle1.64563058
35MP0001835_abnormal_antigen_presentation1.61926173
36MP0004036_abnormal_muscle_relaxation1.61870360
37MP0005253_abnormal_eye_physiology1.56621453
38MP0006276_abnormal_autonomic_nervous1.55314877
39MP0005174_abnormal_tail_pigmentation1.54617494
40MP0003121_genomic_imprinting1.52511423
41MP0008057_abnormal_DNA_replication1.52271479
42MP0002095_abnormal_skin_pigmentation1.50792846
43MP0003787_abnormal_imprinting1.50273726
44MP0005266_abnormal_metabolism1.49164095
45MP0003221_abnormal_cardiomyocyte_apopto1.47055354
46MP0004215_abnormal_myocardial_fiber1.45152336
47MP0002638_abnormal_pupillary_reflex1.43701010
48MP0005084_abnormal_gallbladder_morpholo1.43145102
49MP0005319_abnormal_enzyme/_coenzyme1.40039433
50MP0001984_abnormal_olfaction1.39816556
51MP0004147_increased_porphyrin_level1.39104431
52MP0003718_maternal_effect1.33891867
53MP0002396_abnormal_hematopoietic_system1.32836687
54MP0003111_abnormal_nucleus_morphology1.31170654
55MP0002736_abnormal_nociception_after1.30870118
56MP0002160_abnormal_reproductive_system1.30505227
57MP0008789_abnormal_olfactory_epithelium1.29849218
58MP0002277_abnormal_respiratory_mucosa1.29320432
59MP0004145_abnormal_muscle_electrophysio1.26411822
60MP0008877_abnormal_DNA_methylation1.24999293
61MP0001986_abnormal_taste_sensitivity1.24401589
62MP0004142_abnormal_muscle_tone1.24355873
63MP0003011_delayed_dark_adaptation1.22727568
64MP0004885_abnormal_endolymph1.22037915
65MP0008007_abnormal_cellular_replicative1.21131355
66MP0003195_calcinosis1.20860540
67MP0009046_muscle_twitch1.20229813
68MP0000427_abnormal_hair_cycle1.20131694
69MP0000358_abnormal_cell_content/1.18758387
70MP0005389_reproductive_system_phenotype1.17003578
71MP0002210_abnormal_sex_determination1.14701435
72MP0002751_abnormal_autonomic_nervous1.14667235
73MP0001929_abnormal_gametogenesis1.14284733
74MP0000751_myopathy1.13017138
75MP0005584_abnormal_enzyme/coenzyme_acti1.12429688
76MP0008995_early_reproductive_senescence1.10549196
77MP0005410_abnormal_fertilization1.08963729
78MP0001968_abnormal_touch/_nociception1.08468483
79MP0008932_abnormal_embryonic_tissue1.04090677
80MP0003868_abnormal_feces_composition1.03658593
81MP0002269_muscular_atrophy1.03543671
82MP0005376_homeostasis/metabolism_phenot1.02371855
83MP0003698_abnormal_male_reproductive1.01910221
84MP0008058_abnormal_DNA_repair1.01500532
85MP0000653_abnormal_sex_gland1.00628637
86MP0006054_spinal_hemorrhage0.99630282
87MP0002928_abnormal_bile_duct0.98764670
88MP0005377_hearing/vestibular/ear_phenot0.98657297
89MP0003878_abnormal_ear_physiology0.98657297
90MP0000631_abnormal_neuroendocrine_gland0.97802982
91MP0003123_paternal_imprinting0.97386828
92MP0003950_abnormal_plasma_membrane0.97200865
93MP0002876_abnormal_thyroid_physiology0.97188888
94MP0000609_abnormal_liver_physiology0.96352989
95MP0003786_premature_aging0.96122498
96MP0000598_abnormal_liver_morphology0.94850654
97MP0009745_abnormal_behavioral_response0.94287239
98MP0005330_cardiomyopathy0.93374465
99MP0002972_abnormal_cardiac_muscle0.93164961
100MP0001485_abnormal_pinna_reflex0.92433439
101MP0000343_altered_response_to0.92138110
102MP0005083_abnormal_biliary_tract0.90878760
103MP0001145_abnormal_male_reproductive0.90819084
104MP0000015_abnormal_ear_pigmentation0.90445500
105MP0006292_abnormal_olfactory_placode0.89682154
106MP0001119_abnormal_female_reproductive0.89650331
107MP0003252_abnormal_bile_duct0.88611806
108MP0004381_abnormal_hair_follicle0.86386711
109MP0001853_heart_inflammation0.86053006
110MP0009840_abnormal_foam_cell0.85797212
111MP0003191_abnormal_cellular_cholesterol0.85788944
112MP0005645_abnormal_hypothalamus_physiol0.85787949
113MP0004133_heterotaxia0.85549718
114MP0005464_abnormal_platelet_physiology0.85161768
115MP0000689_abnormal_spleen_morphology0.84839537
116MP0004782_abnormal_surfactant_physiolog0.84287198
117MP0001324_abnormal_eye_pigmentation0.83362258
118MP0001905_abnormal_dopamine_level0.83227642
119MP0005075_abnormal_melanosome_morpholog0.82574996
120MP0002138_abnormal_hepatobiliary_system0.81769612
121MP0001293_anophthalmia0.81406378
122MP0003880_abnormal_central_pattern0.81223947
123MP0005620_abnormal_muscle_contractility0.81045428
124MP0004484_altered_response_of0.80868421
125MP0008775_abnormal_heart_ventricle0.80137156
126MP0004742_abnormal_vestibular_system0.79970262
127MP0001730_embryonic_growth_arrest0.79459879
128MP0008469_abnormal_protein_level0.78140778
129MP0001544_abnormal_cardiovascular_syste0.77469270
130MP0005385_cardiovascular_system_phenoty0.77469270
131MP0001188_hyperpigmentation0.76450095
132MP0008872_abnormal_physiological_respon0.75895337
133MP0005408_hypopigmentation0.75863542
134MP0002118_abnormal_lipid_homeostasis0.75766306
135MP0005671_abnormal_response_to0.75580170
136MP0003436_decreased_susceptibility_to0.75115951
137MP0005499_abnormal_olfactory_system0.74510453
138MP0005394_taste/olfaction_phenotype0.74510453
139MP0003890_abnormal_embryonic-extraembry0.74406566
140MP0002090_abnormal_vision0.73588712
141MP0002272_abnormal_nervous_system0.73189104
142MP0002127_abnormal_cardiovascular_syste0.73023168
143MP0001666_abnormal_nutrient_absorption0.72504304
144MP0009785_altered_susceptibility_to0.72170287
145MP0003122_maternal_imprinting0.71697928
146MP0009763_increased_sensitivity_to0.70970685
147MP0002067_abnormal_sensory_capabilities0.68846587
148MP0001486_abnormal_startle_reflex0.68633352
149MP0005195_abnormal_posterior_eye0.68325050
150MP0005670_abnormal_white_adipose0.68188230
151MP0004924_abnormal_behavior0.68144235
152MP0005386_behavior/neurological_phenoty0.68144235
153MP0006082_CNS_inflammation0.66035563
154MP0002019_abnormal_tumor_incidence0.65800298
155MP0002722_abnormal_immune_system0.65514288
156MP0001545_abnormal_hematopoietic_system0.65213991
157MP0005397_hematopoietic_system_phenotyp0.65213991
158MP0002106_abnormal_muscle_physiology0.65122602
159MP0005636_abnormal_mineral_homeostasis0.64579925
160MP0000747_muscle_weakness0.64395981
161MP0003567_abnormal_fetal_cardiomyocyte0.64273381
162MP0005647_abnormal_sex_gland0.63798910

Predicted human phenotypes

RankGene SetZ-score
1Increased serum pyruvate (HP:0003542)5.19278599
2Abnormality of glycolysis (HP:0004366)5.19278599
3Acute necrotizing encephalopathy (HP:0006965)4.57518284
4Abnormal mitochondria in muscle tissue (HP:0008316)4.45362618
5Acute encephalopathy (HP:0006846)4.37456706
6Mitochondrial inheritance (HP:0001427)4.30824763
7Increased CSF lactate (HP:0002490)4.16570357
8Lipid accumulation in hepatocytes (HP:0006561)4.14447037
9Hepatocellular necrosis (HP:0001404)4.12807500
10Hepatic necrosis (HP:0002605)4.01795366
11Increased hepatocellular lipid droplets (HP:0006565)3.97867974
12Cerebral edema (HP:0002181)3.93479782
13Pancreatic cysts (HP:0001737)3.85983259
14Progressive macrocephaly (HP:0004481)3.76987040
15Increased intramyocellular lipid droplets (HP:0012240)3.71967875
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.69661835
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.69661835
18Increased muscle lipid content (HP:0009058)3.68768893
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.56329146
20Microvesicular hepatic steatosis (HP:0001414)3.51328677
21Nephronophthisis (HP:0000090)3.50623368
22Aplastic anemia (HP:0001915)3.43597413
23Lactic acidosis (HP:0003128)3.41197120
24Increased serum lactate (HP:0002151)3.38066847
25Pancreatic fibrosis (HP:0100732)3.35090758
26Ragged-red muscle fibers (HP:0003200)3.34046919
27Abnormality of aromatic amino acid family metabolism (HP:0004338)3.29987307
28Renal Fanconi syndrome (HP:0001994)3.28219229
29Exercise intolerance (HP:0003546)3.22001894
30Abnormality of the renal cortex (HP:0011035)3.19276412
31Exertional dyspnea (HP:0002875)3.13065512
32True hermaphroditism (HP:0010459)3.11701381
33Abnormality of the renal medulla (HP:0100957)3.11592515
34Birth length less than 3rd percentile (HP:0003561)3.10942146
35Abnormality of methionine metabolism (HP:0010901)3.07593148
36Aplasia/Hypoplasia of the uvula (HP:0010293)3.06613746
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.06184788
38Chromosomal breakage induced by crosslinking agents (HP:0003221)3.05550894
39Rhabdomyolysis (HP:0003201)2.98660776
40Abnormality of midbrain morphology (HP:0002418)2.87597386
41Molar tooth sign on MRI (HP:0002419)2.87597386
42Thrombocytosis (HP:0001894)2.86609178
43Medial flaring of the eyebrow (HP:0010747)2.83334282
44Hypobetalipoproteinemia (HP:0003563)2.82436531
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.77880771
46Abnormality of fatty-acid metabolism (HP:0004359)2.74958118
47Lethargy (HP:0001254)2.74590722
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.71921640
49Respiratory failure (HP:0002878)2.71856568
50Congenital stationary night blindness (HP:0007642)2.70625403
51Hyperammonemia (HP:0001987)2.69937633
52Prolonged partial thromboplastin time (HP:0003645)2.68909341
53Chronic hepatic failure (HP:0100626)2.65813135
54Delayed CNS myelination (HP:0002188)2.65335926
55Abnormality of the ileum (HP:0001549)2.64409048
56Respiratory difficulties (HP:0002880)2.64103190
57Abnormality of pyrimidine metabolism (HP:0004353)2.62111158
58Meckel diverticulum (HP:0002245)2.58699529
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53806115
60Dicarboxylic aciduria (HP:0003215)2.53806115
61Renal cortical cysts (HP:0000803)2.53662835
62Methylmalonic acidemia (HP:0002912)2.49407938
63Abnormality of serum amino acid levels (HP:0003112)2.49210775
64Agnosia (HP:0010524)2.48424388
65Abnormality of chromosome stability (HP:0003220)2.48372207
66Intrahepatic cholestasis (HP:0001406)2.47523503
67IgM deficiency (HP:0002850)2.46366062
68Myoglobinuria (HP:0002913)2.44695112
69Oral leukoplakia (HP:0002745)2.44662844
70Exercise-induced muscle cramps (HP:0003710)2.43427492
71Abnormality of monocarboxylic acid metabolism (HP:0010996)2.42537613
72Intestinal atresia (HP:0011100)2.42048795
73Abolished electroretinogram (ERG) (HP:0000550)2.36623863
74Type I transferrin isoform profile (HP:0003642)2.36384771
75Abnormality of glycine metabolism (HP:0010895)2.31658790
76Abnormality of serine family amino acid metabolism (HP:0010894)2.31658790
77Abnormal biliary tract physiology (HP:0012439)2.31284538
78Bile duct proliferation (HP:0001408)2.31284538
79CNS demyelination (HP:0007305)2.30077984
80Progressive inability to walk (HP:0002505)2.29858196
81Megaloblastic anemia (HP:0001889)2.28889273
82Ketosis (HP:0001946)2.28884875
83Abnormality of the preputium (HP:0100587)2.28569581
843-Methylglutaconic aciduria (HP:0003535)2.28507557
85Congenital primary aphakia (HP:0007707)2.28197419
86Abnormality of the pons (HP:0007361)2.27100262
87Colon cancer (HP:0003003)2.25687243
88Aplasia/Hypoplasia of the tibia (HP:0005772)2.25104240
89Hyperglycinuria (HP:0003108)2.24852116
90Methylmalonic aciduria (HP:0012120)2.23276102
91Hyperglycinemia (HP:0002154)2.22048215
92Abnormality of cells of the erythroid lineage (HP:0012130)2.20010069
93Abnormal number of erythroid precursors (HP:0012131)2.19190075
94Gait imbalance (HP:0002141)2.19059215
95Abnormality of sulfur amino acid metabolism (HP:0004339)2.18322599
96Leukodystrophy (HP:0002415)2.18150823
97Large for gestational age (HP:0001520)2.17775578
98Pendular nystagmus (HP:0012043)2.17383683
99Tongue fasciculations (HP:0001308)2.16226615
100Pancytopenia (HP:0001876)2.12697341
101Complement deficiency (HP:0004431)2.12322141
102Metabolic acidosis (HP:0001942)2.11570962
103Hypoglycemic coma (HP:0001325)2.09583154
104Postaxial foot polydactyly (HP:0001830)2.07829818
105Abnormality of the labia minora (HP:0012880)2.06898852
106Nephrogenic diabetes insipidus (HP:0009806)2.06234166
107Clubbing of toes (HP:0100760)2.05386424
108Aplasia/Hypoplasia of the tongue (HP:0010295)2.04921690
109Optic disc pallor (HP:0000543)2.04687304
110Glycosuria (HP:0003076)2.04430385
111Abnormality of urine glucose concentration (HP:0011016)2.04430385
112Abnormal rod and cone electroretinograms (HP:0008323)2.01917598
113Vomiting (HP:0002013)2.01357983
114Hypoplasia of the pons (HP:0012110)1.99961562
115Generalized aminoaciduria (HP:0002909)1.99386283
116Attenuation of retinal blood vessels (HP:0007843)1.98615740
117Cystic liver disease (HP:0006706)1.97204062
118Pancreatic islet-cell hyperplasia (HP:0004510)1.97022572
119Volvulus (HP:0002580)1.95185168
120Abnormality of the intrinsic pathway (HP:0010989)1.94042510
121Neoplasm of the adrenal cortex (HP:0100641)1.93865326
122Hyperventilation (HP:0002883)1.93661721
123Sloping forehead (HP:0000340)1.93386841
124Small intestinal stenosis (HP:0012848)1.93345783
125Duodenal stenosis (HP:0100867)1.93345783
126Short tibia (HP:0005736)1.92639120
127Abnormality of the vitamin B12 metabolism (HP:0004341)1.92537408
128Abnormality of renal resorption (HP:0011038)1.91134916
129Inability to walk (HP:0002540)1.89903905
130Gliosis (HP:0002171)1.89902540
131Rimmed vacuoles (HP:0003805)1.89676238
132Muscle fibrillation (HP:0010546)1.88353090
133Optic nerve hypoplasia (HP:0000609)1.87613223
134Supernumerary spleens (HP:0009799)1.87445587
135Ketoacidosis (HP:0001993)1.87216257
136Macrocytic anemia (HP:0001972)1.86924828
137Genital tract atresia (HP:0001827)1.85310993
138Cholecystitis (HP:0001082)1.85227732
139Abnormal gallbladder physiology (HP:0012438)1.85227732
140Chromsome breakage (HP:0040012)1.84708185
141Gaze-evoked nystagmus (HP:0000640)1.84491921
142Reduced antithrombin III activity (HP:0001976)1.83326583
143Exercise-induced myalgia (HP:0003738)1.82368588
144Anencephaly (HP:0002323)1.81958027
145Hyperlipoproteinemia (HP:0010980)1.81952428
146Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81928038
147Abnormality of alanine metabolism (HP:0010916)1.81928038
148Hyperalaninemia (HP:0003348)1.81928038
149Congenital hepatic fibrosis (HP:0002612)1.81668313
150Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80175525
151Abnormal protein N-linked glycosylation (HP:0012347)1.80175525
152Abnormal protein glycosylation (HP:0012346)1.80175525
153Abnormal glycosylation (HP:0012345)1.80175525
154Xanthomatosis (HP:0000991)1.80017088
155Abnormality of vitamin B metabolism (HP:0004340)1.79948234
156Acanthocytosis (HP:0001927)1.79822219
157Tubular atrophy (HP:0000092)1.79789662
158Hypolipoproteinemia (HP:0010981)1.79561043
159Abnormality of the duodenum (HP:0002246)1.77822412
160Deep venous thrombosis (HP:0002625)1.77633107
161Vaginal atresia (HP:0000148)1.77305257
162Astigmatism (HP:0000483)1.76193372
163Gonadotropin excess (HP:0000837)1.75715729
164Sclerocornea (HP:0000647)1.74691578
165Aplasia/Hypoplasia of the fovea (HP:0008060)1.74404099
166Hypoplasia of the fovea (HP:0007750)1.74404099
167Abnormal drinking behavior (HP:0030082)1.73552406
168Polydipsia (HP:0001959)1.73552406
169Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73232791
170Postaxial hand polydactyly (HP:0001162)1.72836894
171Aplasia/Hypoplasia of the spleen (HP:0010451)1.68351632
172Abnormal lung lobation (HP:0002101)1.67450894
173Septo-optic dysplasia (HP:0100842)1.66739698
174Fair hair (HP:0002286)1.66735109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.41812562
2BUB14.14690220
3NUAK14.07727622
4WEE13.82269750
5FRK3.43520960
6MAP4K23.41487251
7STK163.33525719
8ACVR1B3.09150290
9BRSK23.00570349
10NEK12.97725692
11WNK32.75206479
12EIF2AK12.71447799
13BCKDK2.53360210
14NME22.24493857
15SRPK12.22231524
16PLK42.20284920
17CCNB12.14782871
18MAP3K122.13365212
19TRIM282.01012645
20SIK31.98070214
21OBSCN1.84737780
22MST41.83878343
23TGFBR11.83158493
24VRK11.82119593
25MKNK21.82068689
26FLT31.77239451
27GRK11.71198379
28TXK1.70776498
29BRSK11.67655126
30TNIK1.59092035
31KIT1.51403653
32MYLK1.50224096
33MUSK1.48223035
34PINK11.45942152
35IRAK11.43715142
36CDC71.42388149
37PDK41.39245227
38PDK31.39245227
39EIF2AK31.37952053
40TSSK61.37724844
41ZAK1.37401081
42NLK1.37000209
43STK31.36763836
44TIE11.34813554
45MKNK11.34558488
46PIM21.30063063
47ERBB31.25908403
48BMPR1B1.24884436
49STK241.23353027
50DAPK11.18607493
51WNK41.12650567
52PLK31.07137668
53MAPK131.05901944
54NEK91.04205266
55CASK1.03325652
56MAP2K31.02838322
57TAF11.02614466
58ADRBK21.02487611
59IRAK21.02273292
60MAP2K71.01716338
61TLK11.00355712
62PLK10.99887575
63TTK0.97425083
64INSRR0.96713610
65DYRK30.95990062
66PLK20.92220026
67TNK20.89957354
68STK40.86932925
69NEK20.85951969
70MAP2K40.85787110
71BMPR20.85176579
72AKT30.84646777
73CAMKK20.84010937
74SYK0.83072806
75RAF10.83062012
76BRAF0.82863611
77MAP3K60.82843614
78PASK0.82591981
79PDK20.82313415
80GRK70.81180562
81TEC0.79823579
82CDK80.79529804
83ARAF0.78997532
84BCR0.78842404
85RPS6KB20.77504934
86MAP4K10.77255951
87PIK3CG0.76417921
88NME10.75171893
89GRK60.73256125
90ABL20.72206676
91ATR0.71540198
92OXSR10.69684513
93AURKA0.68864369
94RPS6KA40.66015699
95DAPK20.63561268
96MAP3K30.63354278
97DYRK20.63336666
98PRKCQ0.62876499
99AURKB0.61863398
100MAP2K60.60212833
101RIPK40.59693733
102CDK190.58863351
103NTRK30.57880132
104VRK20.57198990
105STK38L0.54349070
106BTK0.53659572
107CSNK2A10.53081194
108CSNK2A20.52985529
109MAPKAPK50.51784103
110CSF1R0.51456483
111IRAK40.50540899
112MAPK40.49564060
113TAOK30.48468393
114TYK20.48390338
115MAP3K40.48314672
116ADRBK10.48115484
117LYN0.47346179
118PAK30.46938783
119PIM10.45751465
120CSNK1G10.44588010
121LIMK10.44249387
122PAK40.44060590
123PRKCG0.44002884
124CSNK1A1L0.43012032
125STK390.41679403
126TESK10.41486671
127ITK0.41230735
128CHEK20.41056939
129PRKCE0.40991939
130DAPK30.40287980
131MINK10.38376862
132CDK70.37943824
133ATM0.37685898
134RPS6KA50.37665751
135MAP3K80.37664540
136SCYL20.37153954
137PNCK0.37046215
138CDK40.36064692
139EPHA40.35684906
140CSNK1G20.35465076
141ERBB40.32129333
142MAP3K50.31617586
143CDK30.31571812
144CSNK1G30.30973520
145FES0.30942758
146EIF2AK20.27561347
147MELK0.26867402
148CSNK1A10.26775276
149PRKAA20.26611816
150FER0.23987415
151PTK2B0.22401341
152CAMK2A0.20876540
153PBK0.19602392

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.32273370
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.89545101
3DNA replication_Homo sapiens_hsa030302.88287046
4Oxidative phosphorylation_Homo sapiens_hsa001902.76047249
5Mismatch repair_Homo sapiens_hsa034302.72317786
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.52182584
7Ribosome_Homo sapiens_hsa030102.46642879
8Parkinsons disease_Homo sapiens_hsa050122.44560348
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.42800624
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.35955959
11RNA polymerase_Homo sapiens_hsa030202.20285494
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.13630909
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08386636
14One carbon pool by folate_Homo sapiens_hsa006702.07283727
15Propanoate metabolism_Homo sapiens_hsa006402.05523245
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.99072221
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98769500
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98034858
19Phototransduction_Homo sapiens_hsa047441.96985701
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.91181612
21Carbon metabolism_Homo sapiens_hsa012001.87794734
22Biosynthesis of amino acids_Homo sapiens_hsa012301.81849394
23Homologous recombination_Homo sapiens_hsa034401.75455911
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73436058
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.71985459
26Huntingtons disease_Homo sapiens_hsa050161.71351506
27Pyruvate metabolism_Homo sapiens_hsa006201.67872636
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67778203
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63098247
30Pyrimidine metabolism_Homo sapiens_hsa002401.62402482
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.61506117
32Nucleotide excision repair_Homo sapiens_hsa034201.58496545
33Fatty acid degradation_Homo sapiens_hsa000711.56194880
34Peroxisome_Homo sapiens_hsa041461.54750318
35Alzheimers disease_Homo sapiens_hsa050101.52247874
36Protein export_Homo sapiens_hsa030601.50975614
37Folate biosynthesis_Homo sapiens_hsa007901.47290370
38Spliceosome_Homo sapiens_hsa030401.45710534
39RNA degradation_Homo sapiens_hsa030181.42468619
40Linoleic acid metabolism_Homo sapiens_hsa005911.39335931
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39217006
42Base excision repair_Homo sapiens_hsa034101.36611087
43RNA transport_Homo sapiens_hsa030131.36185924
44Primary immunodeficiency_Homo sapiens_hsa053401.34772592
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33221461
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31539092
47Basal transcription factors_Homo sapiens_hsa030221.27634823
48Ether lipid metabolism_Homo sapiens_hsa005651.22026806
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.21816289
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19144886
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18966493
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17255507
53Fatty acid elongation_Homo sapiens_hsa000621.16377229
54Arginine biosynthesis_Homo sapiens_hsa002201.16319401
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15528476
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13919719
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11718379
58Complement and coagulation cascades_Homo sapiens_hsa046101.07536459
59Cell cycle_Homo sapiens_hsa041101.06848121
60Non-homologous end-joining_Homo sapiens_hsa034501.06543102
61Phenylalanine metabolism_Homo sapiens_hsa003601.06463055
62Fatty acid metabolism_Homo sapiens_hsa012121.05522675
63Cyanoamino acid metabolism_Homo sapiens_hsa004601.04791595
64Nicotine addiction_Homo sapiens_hsa050331.04492493
65beta-Alanine metabolism_Homo sapiens_hsa004101.04416082
66Tryptophan metabolism_Homo sapiens_hsa003801.03483537
67Selenocompound metabolism_Homo sapiens_hsa004501.01914735
68Purine metabolism_Homo sapiens_hsa002301.01472665
69Tyrosine metabolism_Homo sapiens_hsa003501.01445289
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00598984
71Regulation of autophagy_Homo sapiens_hsa041400.99158965
72Fanconi anemia pathway_Homo sapiens_hsa034600.96413110
73Pentose phosphate pathway_Homo sapiens_hsa000300.90133185
74Cardiac muscle contraction_Homo sapiens_hsa042600.89357486
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82942526
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82579400
77Metabolic pathways_Homo sapiens_hsa011000.81118651
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78708078
79Butanoate metabolism_Homo sapiens_hsa006500.78702398
80Chemical carcinogenesis_Homo sapiens_hsa052040.77255536
81Taste transduction_Homo sapiens_hsa047420.75335559
82Sulfur metabolism_Homo sapiens_hsa009200.74003261
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73372323
84Histidine metabolism_Homo sapiens_hsa003400.72228993
85Caffeine metabolism_Homo sapiens_hsa002320.71789775
86Glutathione metabolism_Homo sapiens_hsa004800.70745489
87Arginine and proline metabolism_Homo sapiens_hsa003300.68051629
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67709339
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67487684
90Vitamin B6 metabolism_Homo sapiens_hsa007500.64597350
91Vitamin digestion and absorption_Homo sapiens_hsa049770.60386830
92Glycerolipid metabolism_Homo sapiens_hsa005610.58531726
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57113521
94Fructose and mannose metabolism_Homo sapiens_hsa000510.56076983
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.54210357
96ABC transporters_Homo sapiens_hsa020100.53712378
97Starch and sucrose metabolism_Homo sapiens_hsa005000.52643864
98Lysine degradation_Homo sapiens_hsa003100.50719963
99Fat digestion and absorption_Homo sapiens_hsa049750.49905579
100Systemic lupus erythematosus_Homo sapiens_hsa053220.48440706
101Olfactory transduction_Homo sapiens_hsa047400.48062611
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47915488
103p53 signaling pathway_Homo sapiens_hsa041150.47752576
104Dorso-ventral axis formation_Homo sapiens_hsa043200.43831753
105Sulfur relay system_Homo sapiens_hsa041220.43817722
106Epstein-Barr virus infection_Homo sapiens_hsa051690.39461029
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39121778
108PPAR signaling pathway_Homo sapiens_hsa033200.38732975
109Staphylococcus aureus infection_Homo sapiens_hsa051500.38063553
110Collecting duct acid secretion_Homo sapiens_hsa049660.36305712
111Arachidonic acid metabolism_Homo sapiens_hsa005900.35985548
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34168611
113Oocyte meiosis_Homo sapiens_hsa041140.34151609
114Nitrogen metabolism_Homo sapiens_hsa009100.33846083
115Serotonergic synapse_Homo sapiens_hsa047260.31074193
116Galactose metabolism_Homo sapiens_hsa000520.28784916
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.28740520
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28359382
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.28251640
120Calcium signaling pathway_Homo sapiens_hsa040200.26909087
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25340696
122Glucagon signaling pathway_Homo sapiens_hsa049220.23151483
123N-Glycan biosynthesis_Homo sapiens_hsa005100.23104624
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22801867
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.22339826
126Steroid biosynthesis_Homo sapiens_hsa001000.17345830
127Retinol metabolism_Homo sapiens_hsa008300.16833255
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15129437
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12355553
130Thyroid cancer_Homo sapiens_hsa052160.11339281
131Vibrio cholerae infection_Homo sapiens_hsa051100.06795223

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