ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore complex assembly (GO:0051292)	4.30883225
2	establishment of protein localization to Golgi (GO:0072600)	4.26413009
3	synaptic vesicle docking involved in exocytosis (GO:0016081)	4.02948639
4	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.78398129
5	protein targeting to Golgi (GO:0000042)	3.72654338
6	nuclear pore organization (GO:0006999)	3.66305162
7	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.55912237
8	interkinetic nuclear migration (GO:0022027)	3.39586913
9	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	3.23006975
10	pore complex assembly (GO:0046931)	3.20037878
11	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.09543754
12	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.09314377
13	negative regulation of vascular permeability (GO:0043116)	3.05578583
14	cerebellar Purkinje cell differentiation (GO:0021702)	3.04142269
15	negative regulation of neurotransmitter secretion (GO:0046929)	3.04061804
16	negative regulation of protein localization to cell surface (GO:2000009)	3.00168294
17	regulation of synaptic vesicle exocytosis (GO:2000300)	2.93096564
18	regulation of cell communication by electrical coupling (GO:0010649)	2.92985480
19	cytoplasmic mRNA processing body assembly (GO:0033962)	2.91116427
20	negative regulation of neurotransmitter transport (GO:0051589)	2.91114536
21	glutamate secretion (GO:0014047)	2.84533501
22	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.82364575
23	regulation of sarcomere organization (GO:0060297)	2.82019669
24	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.80084275
25	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	2.79721230
26	L-amino acid import (GO:0043092)	2.77534675
27	regulation of cAMP-dependent protein kinase activity (GO:2000479)	2.76510551
28	nucleus localization (GO:0051647)	2.76375766
29	protein K48-linked deubiquitination (GO:0071108)	2.73976176
30	microtubule depolymerization (GO:0007019)	2.67249800
31	Golgi to endosome transport (GO:0006895)	2.67103569
32	microtubule polymerization or depolymerization (GO:0031109)	2.66473684
33	regulation of pigment cell differentiation (GO:0050932)	2.63065995
34	vesicle transport along microtubule (GO:0047496)	2.62807412
35	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	2.61975415
36	microtubule anchoring (GO:0034453)	2.61223429
37	regulation of synaptic vesicle transport (GO:1902803)	2.60174847
38	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.58252789
39	protein localization to Golgi apparatus (GO:0034067)	2.55960081
40	regulation of clathrin-mediated endocytosis (GO:2000369)	2.55495811
41	positive regulation of muscle hypertrophy (GO:0014742)	2.53975257
42	positive regulation of cardiac muscle hypertrophy (GO:0010613)	2.53975257
43	synaptic vesicle maturation (GO:0016188)	2.50015818
44	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	2.49810893
45	artery development (GO:0060840)	2.48775187
46	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.48094092
47	cell communication involved in cardiac conduction (GO:0086065)	2.46966274
48	C4-dicarboxylate transport (GO:0015740)	2.46746554
49	synaptic vesicle exocytosis (GO:0016079)	2.45976243
50	protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)	2.44064399
51	ventricular cardiac muscle cell action potential (GO:0086005)	2.42889891
52	musculoskeletal movement (GO:0050881)	2.42769829
53	multicellular organismal movement (GO:0050879)	2.42769829
54	regulation of female receptivity (GO:0045924)	2.41181274
55	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	2.41121372
56	organelle transport along microtubule (GO:0072384)	2.38376651
57	cyclic nucleotide catabolic process (GO:0009214)	2.38117839
58	neuronal action potential propagation (GO:0019227)	2.37978915
59	regulation of voltage-gated calcium channel activity (GO:1901385)	2.37950500
60	cardiac muscle cell action potential (GO:0086001)	2.37525883
61	long-chain fatty acid biosynthetic process (GO:0042759)	2.37137987
62	detection of calcium ion (GO:0005513)	2.37077738
63	membrane depolarization during action potential (GO:0086010)	2.36447499
64	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.34795861
65	cardiac muscle hypertrophy (GO:0003300)	2.33564152
66	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.31132331
67	regulation of translation, ncRNA-mediated (GO:0045974)	2.31132331
68	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.31132331
69	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.29929544
70	genitalia morphogenesis (GO:0035112)	2.29567269
71	clathrin coat assembly (GO:0048268)	2.29431525
72	regulation of establishment of cell polarity (GO:2000114)	2.29400220
73	intra-Golgi vesicle-mediated transport (GO:0006891)	2.27476887
74	calcium ion-dependent exocytosis (GO:0017156)	2.27238226
75	microtubule nucleation (GO:0007020)	2.26958132
76	carnitine shuttle (GO:0006853)	2.26646893
77	Golgi to plasma membrane protein transport (GO:0043001)	2.26261590
78	centrosome duplication (GO:0051298)	2.25615854
79	early endosome to late endosome transport (GO:0045022)	2.25568115
80	vesicle docking (GO:0048278)	2.25522055
81	gamma-aminobutyric acid transport (GO:0015812)	2.25231303
82	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.24960115
83	negative regulation of blood circulation (GO:1903523)	2.24749655
84	positive regulation of glycolytic process (GO:0045821)	2.24504527
85	cAMP catabolic process (GO:0006198)	2.23144437
86	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	2.22573970
87	striated muscle hypertrophy (GO:0014897)	2.22364124
88	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.22135209
89	serotonin metabolic process (GO:0042428)	2.21935054
90	amino acid import (GO:0043090)	2.21654768
91	Golgi to plasma membrane transport (GO:0006893)	2.21313518
92	myelination in peripheral nervous system (GO:0022011)	2.20803936
93	peripheral nervous system axon ensheathment (GO:0032292)	2.20803936
94	atrial cardiac muscle cell action potential (GO:0086014)	2.20307889
95	cardiac muscle cell action potential involved in contraction (GO:0086002)	2.19620561
96	pre-miRNA processing (GO:0031054)	2.19102356
97	fibroblast migration (GO:0010761)	2.18592359
98	cGMP-mediated signaling (GO:0019934)	2.15681531
99	neuron-neuron synaptic transmission (GO:0007270)	2.15327788
100	synaptic vesicle endocytosis (GO:0048488)	2.14061220

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.38130127
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.45272617
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.21132829
4	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.71775867
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.70659188
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.67729181
7	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.51142657
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.50845367
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.43138369
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.42622283
11	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.42234193
12	SMAD4_21799915_ChIP-Seq_A2780_Human	2.19642440
13	AR_21572438_ChIP-Seq_LNCaP_Human	2.14329390
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.13613212
15	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.09980082
16	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.08584435
17	STAT3_23295773_ChIP-Seq_U87_Human	1.94839084
18	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.87710999
19	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.87597893
20	P300_19829295_ChIP-Seq_ESCs_Human	1.86688362
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.85628421
22	FUS_26573619_Chip-Seq_HEK293_Human	1.81466589
23	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.74234849
24	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.70418089
25	TCF4_23295773_ChIP-Seq_U87_Human	1.69109835
26	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.68928017
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.67804647
28	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.64591775
29	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.64006386
30	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.56955186
31	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.50485182
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49831344
33	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.48359782
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.46889259
35	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46033912
36	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.46022598
37	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.43434073
38	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.43102231
39	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.41800636
40	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.41697407
41	AR_25329375_ChIP-Seq_VCAP_Human	1.40733377
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39419345
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.39419345
44	AHR_22903824_ChIP-Seq_MCF-7_Human	1.37205148
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35805112
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.34711492
47	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.33310389
48	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.32853438
49	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.31690144
50	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.28741692
51	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.28230936
52	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28223382
53	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.28223382
54	VDR_22108803_ChIP-Seq_LS180_Human	1.27010893
55	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.23243752
56	EWS_26573619_Chip-Seq_HEK293_Human	1.21646920
57	TP53_16413492_ChIP-PET_HCT116_Human	1.21586978
58	ER_23166858_ChIP-Seq_MCF-7_Human	1.21517420
59	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.20580639
60	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18823094
61	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.16877572
62	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.16877572
63	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.16329677
64	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.15713448
65	AR_19668381_ChIP-Seq_PC3_Human	1.14932430
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14585289
67	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13256983
68	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.11206500
69	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.10063456
70	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.10050780
71	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.09518463
72	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08982828
73	TP53_18474530_ChIP-ChIP_U2OS_Human	1.08321520
74	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07986736
75	TCF4_22108803_ChIP-Seq_LS180_Human	1.07791131
76	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06939418
77	P53_22387025_ChIP-Seq_ESCs_Mouse	1.06388222
78	SOX9_26525672_Chip-Seq_HEART_Mouse	1.05474073
79	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.05155268
80	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04669804
81	TBL1_22424771_ChIP-Seq_293T_Human	1.04151252
82	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.03882402
83	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03489788
84	BCAT_22108803_ChIP-Seq_LS180_Human	1.03271355
85	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.01450561
86	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00565479
87	CDX2_22108803_ChIP-Seq_LS180_Human	1.00154301
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99893303
89	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.99647071
90	KDM2B_26808549_Chip-Seq_REH_Human	0.99618097
91	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99106517
92	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.98848908
93	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.97171040
94	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.94748100
95	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.93699436
96	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.93129666
97	JUN_21703547_ChIP-Seq_K562_Human	0.92777269
98	DROSHA_22980978_ChIP-Seq_HELA_Human	0.92490266
99	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.92396816
100	REST_21632747_ChIP-Seq_MESCs_Mouse	0.91459105

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004270_analgesia	3.00070065
2	MP0000569_abnormal_digit_pigmentation	2.82336545
3	MP0004859_abnormal_synaptic_plasticity	2.71304763
4	MP0009046_muscle_twitch	2.60699227
5	MP0002009_preneoplasia	2.58650600
6	MP0008057_abnormal_DNA_replication	2.50218926
7	MP0003646_muscle_fatigue	2.26361728
8	MP0009780_abnormal_chondrocyte_physiolo	2.22171604
9	MP0010352_gastrointestinal_tract_polyps	2.19037748
10	MP0009697_abnormal_copulation	2.12697397
11	MP0004036_abnormal_muscle_relaxation	2.09497186
12	MP0003880_abnormal_central_pattern	2.04174883
13	MP0004084_abnormal_cardiac_muscle	2.04156722
14	MP0004130_abnormal_muscle_cell	2.03380210
15	MP0001486_abnormal_startle_reflex	1.97518599
16	MP0005670_abnormal_white_adipose	1.88523901
17	MP0003635_abnormal_synaptic_transmissio	1.81477278
18	MP0004215_abnormal_myocardial_fiber	1.76524390
19	MP0001984_abnormal_olfaction	1.75407362
20	MP0003879_abnormal_hair_cell	1.73066051
21	MP0006276_abnormal_autonomic_nervous	1.71186067
22	MP0003941_abnormal_skin_development	1.70569056
23	MP0002064_seizures	1.65829169
24	MP0002272_abnormal_nervous_system	1.62773020
25	MP0003890_abnormal_embryonic-extraembry	1.57760807
26	MP0002063_abnormal_learning/memory/cond	1.56348146
27	MP0008004_abnormal_stomach_pH	1.55831966
28	MP0005409_darkened_coat_color	1.54414983
29	MP0005646_abnormal_pituitary_gland	1.53583223
30	MP0001501_abnormal_sleep_pattern	1.48820230
31	MP0004145_abnormal_muscle_electrophysio	1.48641152
32	MP0005187_abnormal_penis_morphology	1.46727474
33	MP0009745_abnormal_behavioral_response	1.41815850
34	MP0004233_abnormal_muscle_weight	1.41153158
35	MP0001879_abnormal_lymphatic_vessel	1.40761804
36	MP0005167_abnormal_blood-brain_barrier	1.38079013
37	MP0004484_altered_response_of	1.36726630
38	MP0002572_abnormal_emotion/affect_behav	1.34743079
39	MP0004085_abnormal_heartbeat	1.33205815
40	MP0004924_abnormal_behavior	1.30660159
41	MP0005386_behavior/neurological_phenoty	1.30660159
42	MP0005423_abnormal_somatic_nervous	1.30110848
43	MP0001661_extended_life_span	1.28599251
44	MP0004134_abnormal_chest_morphology	1.26004530
45	MP0002734_abnormal_mechanical_nocicepti	1.22301560
46	MP0001299_abnormal_eye_distance/	1.21735498
47	MP0002638_abnormal_pupillary_reflex	1.20761612
48	MP0002557_abnormal_social/conspecific_i	1.17666291
49	MP0001188_hyperpigmentation	1.17326690
50	MP0004147_increased_porphyrin_level	1.15551171
51	MP0005410_abnormal_fertilization	1.13637663
52	MP0003633_abnormal_nervous_system	1.10427352
53	MP0002067_abnormal_sensory_capabilities	1.09041126
54	MP0002822_catalepsy	1.08267635
55	MP0008569_lethality_at_weaning	1.06248862
56	MP0000383_abnormal_hair_follicle	1.05780560
57	MP0006138_congestive_heart_failure	1.05764638
58	MP0005645_abnormal_hypothalamus_physiol	1.05423951
59	MP0002735_abnormal_chemical_nociception	1.04171761
60	MP0010386_abnormal_urinary_bladder	1.01652936
61	MP0005620_abnormal_muscle_contractility	0.99971833
62	MP0005551_abnormal_eye_electrophysiolog	0.99896655
63	MP0003787_abnormal_imprinting	0.98277125
64	MP0005666_abnormal_adipose_tissue	0.98066136
65	MP0003868_abnormal_feces_composition	0.96800881
66	MP0003137_abnormal_impulse_conducting	0.95106637
67	MP0000465_gastrointestinal_hemorrhage	0.93990274
68	MP0004811_abnormal_neuron_physiology	0.91136146
69	MP0005253_abnormal_eye_physiology	0.91038878
70	MP0005083_abnormal_biliary_tract	0.90611793
71	MP0000751_myopathy	0.90011284
72	MP0000778_abnormal_nervous_system	0.88343546
73	MP0003631_nervous_system_phenotype	0.87745710
74	MP0010678_abnormal_skin_adnexa	0.87659096
75	MP0000230_abnormal_systemic_arterial	0.85936907
76	MP0001968_abnormal_touch/_nociception	0.85812904
77	MP0000013_abnormal_adipose_tissue	0.85636393
78	MP0008877_abnormal_DNA_methylation	0.84697279
79	MP0002332_abnormal_exercise_endurance	0.84234391
80	MP0000631_abnormal_neuroendocrine_gland	0.83748020
81	MP0010329_abnormal_lipoprotein_level	0.82410634
82	MP0004043_abnormal_pH_regulation	0.81876434
83	MP0002876_abnormal_thyroid_physiology	0.79972130
84	MP0002733_abnormal_thermal_nociception	0.79871911
85	MP0002972_abnormal_cardiac_muscle	0.78391702
86	MP0009115_abnormal_fat_cell	0.78271171
87	MP0000427_abnormal_hair_cycle	0.78269531
88	MP0002106_abnormal_muscle_physiology	0.78171117
89	MP0008775_abnormal_heart_ventricle	0.76680071
90	MP0002971_abnormal_brown_adipose	0.76184758
91	MP0003698_abnormal_male_reproductive	0.76093241
92	MP0002882_abnormal_neuron_morphology	0.75978416
93	MP0001502_abnormal_circadian_rhythm	0.75305072
94	MP0000955_abnormal_spinal_cord	0.74095278
95	MP0001485_abnormal_pinna_reflex	0.73762824
96	MP0000647_abnormal_sebaceous_gland	0.72229794
97	MP0002234_abnormal_pharynx_morphology	0.72177844
98	MP0002184_abnormal_innervation	0.70583519
99	MP0002066_abnormal_motor_capabilities/c	0.69909638
100	MP0008961_abnormal_basal_metabolism	0.69364396

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Papillary thyroid carcinoma (HP:0002895)	4.19237171
2	Febrile seizures (HP:0002373)	3.51102940
3	Progressive cerebellar ataxia (HP:0002073)	3.11500709
4	Tubulointerstitial nephritis (HP:0001970)	3.10766159
5	Genetic anticipation (HP:0003743)	3.08527760
6	Atonic seizures (HP:0010819)	3.00521842
7	Hyperventilation (HP:0002883)	2.90195241
8	Hyperkalemia (HP:0002153)	2.86474726
9	Drooling (HP:0002307)	2.85588199
10	Chronic hepatic failure (HP:0100626)	2.75406771
11	Urinary bladder sphincter dysfunction (HP:0002839)	2.73618110
12	Gaze-evoked nystagmus (HP:0000640)	2.72609947
13	Truncal obesity (HP:0001956)	2.71762660
14	Urinary urgency (HP:0000012)	2.62892616
15	Hepatoblastoma (HP:0002884)	2.60113939
16	Termporal pattern (HP:0011008)	2.59685511
17	Insidious onset (HP:0003587)	2.59685511
18	Acanthocytosis (HP:0001927)	2.55235360
19	Excessive salivation (HP:0003781)	2.50461558
20	Impaired vibration sensation in the lower limbs (HP:0002166)	2.47496497
21	Thyroid carcinoma (HP:0002890)	2.47305340
22	Abnormality of the astrocytes (HP:0100707)	2.45678391
23	Astrocytoma (HP:0009592)	2.45678391
24	Dysmetric saccades (HP:0000641)	2.45064073
25	Broad-based gait (HP:0002136)	2.41024581
26	Epileptiform EEG discharges (HP:0011182)	2.35567957
27	Fair hair (HP:0002286)	2.33962567
28	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.32654805
29	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.32654805
30	Bundle branch block (HP:0011710)	2.31712598
31	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.30110312
32	Focal seizures (HP:0007359)	2.25843675
33	Insulin-resistant diabetes mellitus (HP:0000831)	2.22778825
34	EEG with generalized epileptiform discharges (HP:0011198)	2.22772773
35	Sudden death (HP:0001699)	2.22586306
36	Right ventricular cardiomyopathy (HP:0011663)	2.21616770
37	Focal motor seizures (HP:0011153)	2.19468534
38	Abnormality of the left ventricular outflow tract (HP:0011103)	2.17552501
39	Subaortic stenosis (HP:0001682)	2.17552501
40	Medulloblastoma (HP:0002885)	2.17372226
41	Hypsarrhythmia (HP:0002521)	2.16458711
42	Abnormality of the ischium (HP:0003174)	2.13803813
43	Hypoplastic labia majora (HP:0000059)	2.12631880
44	Blue irides (HP:0000635)	2.09405170
45	Myokymia (HP:0002411)	2.07439982
46	Abnormality of the corticospinal tract (HP:0002492)	2.06970181
47	Overgrowth (HP:0001548)	2.06770746
48	Abnormality of the labia majora (HP:0012881)	2.04499324
49	Spastic gait (HP:0002064)	2.02449269
50	Absence seizures (HP:0002121)	2.02143621
51	Abnormal social behavior (HP:0012433)	2.02125859
52	Impaired social interactions (HP:0000735)	2.02125859
53	Dialeptic seizures (HP:0011146)	1.99654026
54	Syncope (HP:0001279)	1.98923692
55	Biliary tract neoplasm (HP:0100574)	1.97105170
56	Action tremor (HP:0002345)	1.97056262
57	Neoplasm of the heart (HP:0100544)	1.97036859
58	Generalized hypopigmentation of hair (HP:0011358)	1.96477473
59	Poor eye contact (HP:0000817)	1.96184749
60	Epileptic encephalopathy (HP:0200134)	1.95487286
61	Abnormal auditory evoked potentials (HP:0006958)	1.93058644
62	Poor coordination (HP:0002370)	1.92806472
63	Glioma (HP:0009733)	1.92553117
64	Nemaline bodies (HP:0003798)	1.89649429
65	Protruding tongue (HP:0010808)	1.88776859
66	Abnormality of potassium homeostasis (HP:0011042)	1.88286924
67	Renal cortical cysts (HP:0000803)	1.87698995
68	Impaired vibratory sensation (HP:0002495)	1.87633578
69	Decreased circulating renin level (HP:0003351)	1.86736682
70	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	1.85081562
71	Thyroid-stimulating hormone excess (HP:0002925)	1.84756100
72	Abnormality of secondary sexual hair (HP:0009888)	1.83886618
73	Abnormality of the axillary hair (HP:0100134)	1.83886618
74	Hyporeflexia of lower limbs (HP:0002600)	1.83487017
75	Absent eyebrow (HP:0002223)	1.83247265
76	Neoplasm of striated muscle (HP:0009728)	1.82930104
77	Genital tract atresia (HP:0001827)	1.82901529
78	Abnormality of the fingertips (HP:0001211)	1.82372706
79	Lower limb muscle weakness (HP:0007340)	1.82088394
80	Rhabdomyosarcoma (HP:0002859)	1.80730605
81	Muscle fiber inclusion bodies (HP:0100299)	1.80361829
82	Absent eyelashes (HP:0000561)	1.79768453
83	Postural instability (HP:0002172)	1.78271352
84	Volvulus (HP:0002580)	1.78056623
85	Acute myeloid leukemia (HP:0004808)	1.77370602
86	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.77133716
87	Papilledema (HP:0001085)	1.76866128
88	Vaginal atresia (HP:0000148)	1.76030254
89	Decreased lacrimation (HP:0000633)	1.74181910
90	Abnormality of the renal cortex (HP:0011035)	1.72086243
91	Short chin (HP:0000331)	1.71450607
92	Autoamputation (HP:0001218)	1.71265936
93	Short tibia (HP:0005736)	1.70665062
94	Calf muscle hypertrophy (HP:0008981)	1.70056635
95	Cystic hygroma (HP:0000476)	1.69257750
96	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.67267189
97	Neoplasm of the small intestine (HP:0100833)	1.66544109
98	Failure to thrive in infancy (HP:0001531)	1.66123316
99	Hypoalphalipoproteinemia (HP:0003233)	1.65823179
100	Difficulty running (HP:0009046)	1.65577921

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	AKT3	3.37824678
2	MAP3K4	3.14292812
3	CAMK1G	2.67979307
4	FRK	2.55728649
5	ZAK	2.34260499
6	CAMK1D	2.30794582
7	CASK	2.20733006
8	OBSCN	2.16020509
9	SGK2	2.09488012
10	MAP2K7	1.98803707
11	STK39	1.96293570
12	TLK1	1.78296350
13	EPHA3	1.72583701
14	SGK494	1.67950391
15	SGK223	1.67950391
16	EPHA4	1.67049972
17	BRD4	1.63070338
18	NTRK3	1.61228947
19	CSNK1A1L	1.52293137
20	MARK1	1.45282997
21	FER	1.41409230
22	NLK	1.40831765
23	SGK3	1.38807072
24	CDK12	1.37642579
25	PIK3CG	1.34106258
26	CAMKK2	1.26684500
27	ACVR1B	1.24037425
28	CAMK4	1.18707023
29	CSNK1G1	1.17854686
30	WNK1	1.17730459
31	PLK2	1.14710052
32	MAPK13	1.13511595
33	MAP4K2	1.13292251
34	CAMK1	1.10607612
35	STK38	1.09258785
36	PINK1	1.08193949
37	PIK3CA	1.07434474
38	PLK4	1.07016077
39	PRKAA2	1.05322209
40	BMPR1B	1.05048128
41	LATS1	1.02022868
42	PRKAA1	0.99467724
43	MAP2K4	0.98070134
44	MST4	0.96295470
45	MET	0.95659881
46	SCYL2	0.93396341
47	CSNK1G2	0.92925760
48	BCR	0.90825114
49	MARK2	0.90505488
50	CSNK1G3	0.90414894
51	ERBB3	0.87581596
52	PAK6	0.86276916
53	PHKG1	0.86160585
54	PHKG2	0.86160585
55	STK38L	0.86159361
56	RPS6KA5	0.84082820
57	SGK1	0.83748303
58	TNIK	0.83181683
59	WNK3	0.83037426
60	NEK6	0.82736216
61	PAK3	0.81181881
62	PKN1	0.79949102
63	NTRK2	0.79283915
64	OXSR1	0.75571156
65	MAP3K2	0.74453778
66	TAOK3	0.74261601
67	MAP3K6	0.73250943
68	INSRR	0.72781903
69	PRKCE	0.70446992
70	CDK5	0.67194544
71	TEC	0.65680548
72	WNK4	0.65523266
73	BRSK2	0.62288916
74	RPS6KA3	0.60539906
75	MYLK	0.59546445
76	CAMK2A	0.57001438
77	MST1R	0.56449968
78	MAPK10	0.55758373
79	PRKD3	0.55636015
80	TIE1	0.54738267
81	DAPK2	0.53313958
82	DMPK	0.51973683
83	PRKG1	0.50281917
84	BMPR2	0.50137213
85	MELK	0.49640181
86	DAPK3	0.48331479
87	RET	0.47029467
88	CDK3	0.46519763
89	MINK1	0.46175235
90	CSNK1D	0.45514387
91	STK11	0.45428433
92	CAMK2B	0.45005511
93	VRK1	0.44981345
94	PDGFRB	0.43852961
95	ERBB2	0.43138478
96	JAK1	0.42756830
97	GSK3B	0.41976208
98	PRKCB	0.41704196
99	MAP3K7	0.41315360
100	PRKACB	0.40416405

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Alcoholism_Homo sapiens_hsa05034	3.27365826
2	Systemic lupus erythematosus_Homo sapiens_hsa05322	3.05845637
3	Nicotine addiction_Homo sapiens_hsa05033	2.79941444
4	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.20637193
5	Circadian rhythm_Homo sapiens_hsa04710	2.11430409
6	GABAergic synapse_Homo sapiens_hsa04727	1.91120798
7	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.86342131
8	Morphine addiction_Homo sapiens_hsa05032	1.80461717
9	Circadian entrainment_Homo sapiens_hsa04713	1.68415233
10	Glutamatergic synapse_Homo sapiens_hsa04724	1.57171008
11	Long-term potentiation_Homo sapiens_hsa04720	1.43178261
12	Insulin secretion_Homo sapiens_hsa04911	1.42460505
13	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.40883395
14	Serotonergic synapse_Homo sapiens_hsa04726	1.40125245
15	Dopaminergic synapse_Homo sapiens_hsa04728	1.38957252
16	Amphetamine addiction_Homo sapiens_hsa05031	1.35026539
17	Taste transduction_Homo sapiens_hsa04742	1.33827927
18	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.33369931
19	Olfactory transduction_Homo sapiens_hsa04740	1.32564968
20	Adherens junction_Homo sapiens_hsa04520	1.30049703
21	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.27831884
22	Renin secretion_Homo sapiens_hsa04924	1.24289459
23	Salivary secretion_Homo sapiens_hsa04970	1.21450197
24	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.18640515
25	Long-term depression_Homo sapiens_hsa04730	1.14872748
26	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.14447963
27	Calcium signaling pathway_Homo sapiens_hsa04020	1.13916689
28	Pancreatic secretion_Homo sapiens_hsa04972	1.11712570
29	Renin-angiotensin system_Homo sapiens_hsa04614	1.11118433
30	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.08999442
31	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.06019513
32	Arginine biosynthesis_Homo sapiens_hsa00220	1.04167063
33	Gap junction_Homo sapiens_hsa04540	1.03602046
34	Cholinergic synapse_Homo sapiens_hsa04725	1.02666324
35	cAMP signaling pathway_Homo sapiens_hsa04024	1.00753574
36	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.00657213
37	Gastric acid secretion_Homo sapiens_hsa04971	0.97501641
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.95861190
39	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.95656110
40	Type II diabetes mellitus_Homo sapiens_hsa04930	0.95249166
41	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.95197482
42	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.93107415
43	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.90913849
44	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.89877577
45	Cocaine addiction_Homo sapiens_hsa05030	0.88988690
46	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.87661474
47	Tight junction_Homo sapiens_hsa04530	0.87636609
48	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.85393102
49	Glioma_Homo sapiens_hsa05214	0.83906394
50	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.83852373
51	Platelet activation_Homo sapiens_hsa04611	0.81812111
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.81777402
53	Lysine degradation_Homo sapiens_hsa00310	0.81417739
54	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.81368990
55	ABC transporters_Homo sapiens_hsa02010	0.80526271
56	Propanoate metabolism_Homo sapiens_hsa00640	0.77982962
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.76950800
58	Glucagon signaling pathway_Homo sapiens_hsa04922	0.76356196
59	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.75998011
60	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.75069702
61	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.73670393
62	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.73594057
63	Choline metabolism in cancer_Homo sapiens_hsa05231	0.71976164
64	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.71877770
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.71503687
66	Butanoate metabolism_Homo sapiens_hsa00650	0.71054929
67	Viral carcinogenesis_Homo sapiens_hsa05203	0.69444198
68	Oocyte meiosis_Homo sapiens_hsa04114	0.69394391
69	ErbB signaling pathway_Homo sapiens_hsa04012	0.68536979
70	PPAR signaling pathway_Homo sapiens_hsa03320	0.68426308
71	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68292854
72	Linoleic acid metabolism_Homo sapiens_hsa00591	0.67775240
73	Nitrogen metabolism_Homo sapiens_hsa00910	0.67501579
74	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.64659061
75	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.64551478
76	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63755814
77	AMPK signaling pathway_Homo sapiens_hsa04152	0.63423840
78	ECM-receptor interaction_Homo sapiens_hsa04512	0.63154525
79	Bile secretion_Homo sapiens_hsa04976	0.61708762
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61107296
81	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.59074725
82	Sphingolipid metabolism_Homo sapiens_hsa00600	0.58822474
83	Thyroid cancer_Homo sapiens_hsa05216	0.58725667
84	Insulin signaling pathway_Homo sapiens_hsa04910	0.58590732
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58580971
86	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.56636690
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.56516238
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.55854940
89	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.54774536
90	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.54439809
91	FoxO signaling pathway_Homo sapiens_hsa04068	0.53440855
92	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.52643156
93	Hippo signaling pathway_Homo sapiens_hsa04390	0.52311373
94	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.50952843
95	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.50934731
96	Insulin resistance_Homo sapiens_hsa04931	0.49713138
97	GnRH signaling pathway_Homo sapiens_hsa04912	0.48670764
98	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.48150481
99	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.47728739
100	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.47066574

MTRNR2L1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »