ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to Golgi (GO:0072600)	5.58358790
2	protein targeting to Golgi (GO:0000042)	5.02815421
3	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.85791026
4	sleep (GO:0030431)	4.26553368
5	positive regulation of endothelial cell differentiation (GO:0045603)	3.93360828
6	interkinetic nuclear migration (GO:0022027)	3.72236996
7	protein localization to Golgi apparatus (GO:0034067)	3.69995876
8	protein polyglutamylation (GO:0018095)	3.66499125
9	thrombin receptor signaling pathway (GO:0070493)	3.66458050
10	keratinization (GO:0031424)	3.65142861
11	regulation of endothelial cell differentiation (GO:0045601)	3.54659230
12	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.44922210
13	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	3.43013832
14	early endosome to late endosome transport (GO:0045022)	3.40804505
15	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.31628310
16	rRNA catabolic process (GO:0016075)	3.28762218
17	regulation of cilium movement (GO:0003352)	3.24114212
18	intra-Golgi vesicle-mediated transport (GO:0006891)	3.20961620
19	protein K48-linked deubiquitination (GO:0071108)	3.17052160
20	cilium or flagellum-dependent cell motility (GO:0001539)	3.16068703
21	microtubule nucleation (GO:0007020)	3.15204274
22	microtubule anchoring (GO:0034453)	3.11749045
23	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.07133175
24	artery development (GO:0060840)	2.98576271
25	positive regulation of mitochondrial fission (GO:0090141)	2.89531852
26	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	2.88778705
27	protein K11-linked deubiquitination (GO:0035871)	2.87447773
28	axoneme assembly (GO:0035082)	2.86041015
29	negative regulation of neurotransmitter transport (GO:0051589)	2.85736560
30	platelet dense granule organization (GO:0060155)	2.84575889
31	regulation of memory T cell differentiation (GO:0043380)	2.81046634
32	establishment of skin barrier (GO:0061436)	2.78722217
33	negative regulation of phosphoprotein phosphatase activity (GO:0032515)	2.74148913
34	microtubule depolymerization (GO:0007019)	2.72502536
35	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.71073626
36	positive regulation of microtubule polymerization (GO:0031116)	2.70538655
37	acrosome assembly (GO:0001675)	2.68665209
38	long-chain fatty acid biosynthetic process (GO:0042759)	2.68374041
39	negative regulation of heart rate (GO:0010459)	2.66746460
40	negative regulation of protein localization to cell surface (GO:2000009)	2.66586634
41	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	2.66166006
42	adenosine metabolic process (GO:0046085)	2.65638459
43	negative regulation of vascular permeability (GO:0043116)	2.64375336
44	regulation of sarcomere organization (GO:0060297)	2.64178521
45	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.59249110
46	regulation of clathrin-mediated endocytosis (GO:2000369)	2.58311062
47	cyclic nucleotide catabolic process (GO:0009214)	2.57709869
48	protein K63-linked deubiquitination (GO:0070536)	2.56397663
49	regulation of lipoprotein metabolic process (GO:0050746)	2.55407672
50	cAMP catabolic process (GO:0006198)	2.55120731
51	magnesium ion transport (GO:0015693)	2.55100092
52	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.53226587
53	epithelial cilium movement (GO:0003351)	2.51334970
54	positive regulation of cardiac muscle hypertrophy (GO:0010613)	2.46547649
55	positive regulation of muscle hypertrophy (GO:0014742)	2.46547649
56	microtubule polymerization or depolymerization (GO:0031109)	2.46539944
57	vascular smooth muscle contraction (GO:0014829)	2.45238515
58	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.44292461
59	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.44292461
60	regulation of translation, ncRNA-mediated (GO:0045974)	2.44292461
61	macroautophagy (GO:0016236)	2.43993491
62	regulation of cell communication by electrical coupling (GO:0010649)	2.42161731
63	sperm motility (GO:0030317)	2.41396424
64	DNA dealkylation (GO:0035510)	2.40253108
65	cytoplasmic mRNA processing body assembly (GO:0033962)	2.39525626
66	pyrimidine dimer repair (GO:0006290)	2.38941305
67	protein localization to cilium (GO:0061512)	2.37278948
68	protein localization to microtubule cytoskeleton (GO:0072698)	2.37025480
69	cilium movement (GO:0003341)	2.36988506
70	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.36426047
71	negative regulation of neurotransmitter secretion (GO:0046929)	2.36221141
72	negative regulation of lipid storage (GO:0010888)	2.34456833
73	proline transport (GO:0015824)	2.34239151
74	dopamine transport (GO:0015872)	2.33875119
75	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.33545863
76	retinal cone cell development (GO:0046549)	2.33545138
77	negative regulation of mast cell activation (GO:0033004)	2.33068509
78	cilium morphogenesis (GO:0060271)	2.31557728
79	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.30007974
80	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.30007974
81	regulation of relaxation of muscle (GO:1901077)	2.29740185
82	DNA demethylation (GO:0080111)	2.29738977
83	mitochondrial calcium ion transport (GO:0006851)	2.28792241
84	positive regulation of glycolytic process (GO:0045821)	2.27814786
85	calcium ion import (GO:0070509)	2.27275381
86	photoreceptor cell maintenance (GO:0045494)	2.25432288
87	regulation of germinal center formation (GO:0002634)	2.25416700
88	negative regulation of NF-kappaB import into nucleus (GO:0042347)	2.24517097
89	fucose catabolic process (GO:0019317)	2.23839628
90	L-fucose metabolic process (GO:0042354)	2.23839628
91	L-fucose catabolic process (GO:0042355)	2.23839628
92	amino acid salvage (GO:0043102)	2.23428863
93	L-methionine salvage (GO:0071267)	2.23428863
94	L-methionine biosynthetic process (GO:0071265)	2.23428863
95	cilium organization (GO:0044782)	2.23052501
96	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.21772977
97	regulation of protein glycosylation (GO:0060049)	2.21048881
98	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.18567407
99	regulation of hexokinase activity (GO:1903299)	2.18120247
100	regulation of glucokinase activity (GO:0033131)	2.18120247

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.18410445
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.28152819
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.20754790
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.16305333
5	TAF15_26573619_Chip-Seq_HEK293_Human	2.90663129
6	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.76939087
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.58455967
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.58207127
9	VDR_22108803_ChIP-Seq_LS180_Human	2.46250595
10	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.41330239
11	FUS_26573619_Chip-Seq_HEK293_Human	2.23325149
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15033598
13	SMAD4_21799915_ChIP-Seq_A2780_Human	2.14915899
14	P300_19829295_ChIP-Seq_ESCs_Human	2.13363293
15	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.09545590
16	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.09503497
17	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.04303597
18	ZNF274_21170338_ChIP-Seq_K562_Hela	2.02118260
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.99955346
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.99455840
21	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.93505215
22	AR_21572438_ChIP-Seq_LNCaP_Human	1.83146866
23	STAT3_23295773_ChIP-Seq_U87_Human	1.81052810
24	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.77514399
25	EWS_26573619_Chip-Seq_HEK293_Human	1.71482681
26	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.69686512
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66127677
28	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.65818242
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.65333180
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.63860173
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.62523921
32	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.62492530
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.59044645
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.58467150
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.58467150
36	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.57687229
37	TCF4_23295773_ChIP-Seq_U87_Human	1.53732812
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52440255
39	AR_25329375_ChIP-Seq_VCAP_Human	1.50635216
40	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.48495660
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.47219980
42	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.44846194
43	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.41113965
44	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.39848516
45	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.37609949
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33669760
47	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.32559407
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.28976004
49	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.26874823
50	BCAT_22108803_ChIP-Seq_LS180_Human	1.26717762
51	CDX2_22108803_ChIP-Seq_LS180_Human	1.26207056
52	TCF4_22108803_ChIP-Seq_LS180_Human	1.26175429
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.25843236
54	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.23924506
55	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.23183697
56	AHR_22903824_ChIP-Seq_MCF-7_Human	1.23172882
57	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.22801580
58	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.22220830
59	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.22150059
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21601270
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21280261
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21280261
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21026888
64	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.20962132
65	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.20458142
66	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.20161706
67	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.20161706
68	P53_22387025_ChIP-Seq_ESCs_Mouse	1.19648863
69	GATA1_22025678_ChIP-Seq_K562_Human	1.19344765
70	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.17545420
71	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17490546
72	EZH2_22144423_ChIP-Seq_EOC_Human	1.16618263
73	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.16604662
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.16131406
75	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.13937502
76	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.13826481
77	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.12289207
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12273804
79	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.11820050
80	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.11567833
81	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.09536118
82	TP53_16413492_ChIP-PET_HCT116_Human	1.08813946
83	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.08617303
84	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08268173
85	TP53_22573176_ChIP-Seq_HFKS_Human	1.08003246
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.04624800
87	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03597947
88	HTT_18923047_ChIP-ChIP_STHdh_Human	1.03137369
89	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.02384117
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.02133728
91	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.00813670
92	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99457793
93	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.99457793
94	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.98711273
95	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.98565804
96	AR_20517297_ChIP-Seq_VCAP_Human	0.98262950
97	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.97358634
98	TP53_18474530_ChIP-ChIP_U2OS_Human	0.97191684
99	JUN_21703547_ChIP-Seq_K562_Human	0.95701796
100	CJUN_26792858_Chip-Seq_BT549_Human	0.94800581

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000465_gastrointestinal_hemorrhage	3.22118166
2	MP0002009_preneoplasia	3.17930260
3	MP0000569_abnormal_digit_pigmentation	3.12418033
4	MP0009697_abnormal_copulation	2.84082414
5	MP0009046_muscle_twitch	2.36931426
6	MP0004084_abnormal_cardiac_muscle	2.36792440
7	MP0005083_abnormal_biliary_tract	2.32220416
8	MP0008877_abnormal_DNA_methylation	2.26220634
9	MP0003646_muscle_fatigue	2.25875527
10	MP0001879_abnormal_lymphatic_vessel	2.17778777
11	MP0004147_increased_porphyrin_level	2.12290627
12	MP0004036_abnormal_muscle_relaxation	1.96445178
13	MP0005253_abnormal_eye_physiology	1.88062913
14	MP0005365_abnormal_bile_salt	1.85188304
15	MP0004484_altered_response_of	1.84684386
16	MP0004215_abnormal_myocardial_fiber	1.83966263
17	MP0000383_abnormal_hair_follicle	1.79159376
18	MP0002876_abnormal_thyroid_physiology	1.79020881
19	MP0001984_abnormal_olfaction	1.73188364
20	MP0002102_abnormal_ear_morphology	1.70885999
21	MP0000013_abnormal_adipose_tissue	1.65765594
22	MP0005646_abnormal_pituitary_gland	1.65716896
23	MP0009780_abnormal_chondrocyte_physiolo	1.64380033
24	MP0003724_increased_susceptibility_to	1.64376774
25	MP0008775_abnormal_heart_ventricle	1.59933607
26	MP0005187_abnormal_penis_morphology	1.58336864
27	MP0005085_abnormal_gallbladder_physiolo	1.58140404
28	MP0010352_gastrointestinal_tract_polyps	1.57317001
29	MP0006072_abnormal_retinal_apoptosis	1.56131367
30	MP0000647_abnormal_sebaceous_gland	1.53378888
31	MP0010329_abnormal_lipoprotein_level	1.52445796
32	MP0000427_abnormal_hair_cycle	1.50284731
33	MP0005645_abnormal_hypothalamus_physiol	1.49661296
34	MP0003183_abnormal_peptide_metabolism	1.48341841
35	MP0005551_abnormal_eye_electrophysiolog	1.47724570
36	MP0001486_abnormal_startle_reflex	1.47042282
37	MP0004043_abnormal_pH_regulation	1.45096480
38	MP0008057_abnormal_DNA_replication	1.44380574
39	MP0010368_abnormal_lymphatic_system	1.42253999
40	MP0005167_abnormal_blood-brain_barrier	1.38780166
41	MP0000230_abnormal_systemic_arterial	1.38113300
42	MP0006276_abnormal_autonomic_nervous	1.37652730
43	MP0008004_abnormal_stomach_pH	1.35559937
44	MP0004510_myositis	1.33378600
45	MP0003879_abnormal_hair_cell	1.31841800
46	MP0003718_maternal_effect	1.28899354
47	MP0004085_abnormal_heartbeat	1.27123514
48	MP0004134_abnormal_chest_morphology	1.25838491
49	MP0001501_abnormal_sleep_pattern	1.22615485
50	MP0004145_abnormal_muscle_electrophysio	1.21202453
51	MP0005386_behavior/neurological_phenoty	1.18587886
52	MP0004924_abnormal_behavior	1.18587886
53	MP0002837_dystrophic_cardiac_calcinosis	1.18552991
54	MP0001188_hyperpigmentation	1.18334878
55	MP0004142_abnormal_muscle_tone	1.17946373
56	MP0002272_abnormal_nervous_system	1.17686307
57	MP0002095_abnormal_skin_pigmentation	1.15094600
58	MP0002736_abnormal_nociception_after	1.13946193
59	MP0005670_abnormal_white_adipose	1.12881326
60	MP0001666_abnormal_nutrient_absorption	1.12588242
61	MP0010678_abnormal_skin_adnexa	1.11292261
62	MP0003195_calcinosis	1.11101504
63	MP0002638_abnormal_pupillary_reflex	1.09771973
64	MP0001502_abnormal_circadian_rhythm	1.09394527
65	MP0001765_abnormal_ion_homeostasis	1.08648040
66	MP0005464_abnormal_platelet_physiology	1.06545988
67	MP0004270_analgesia	1.04406111
68	MP0008872_abnormal_physiological_respon	1.04246190
69	MP0004130_abnormal_muscle_cell	1.00545882
70	MP0004264_abnormal_extraembryonic_tissu	0.97737496
71	MP0003787_abnormal_imprinting	0.97357374
72	MP0004885_abnormal_endolymph	0.95683088
73	MP0003941_abnormal_skin_development	0.95199627
74	MP0010386_abnormal_urinary_bladder	0.94940974
75	MP0001529_abnormal_vocalization	0.92017180
76	MP0005410_abnormal_fertilization	0.89910519
77	MP0001968_abnormal_touch/_nociception	0.89057998
78	MP0000631_abnormal_neuroendocrine_gland	0.88606504
79	MP0003950_abnormal_plasma_membrane	0.87119499
80	MP0005084_abnormal_gallbladder_morpholo	0.85972348
81	MP0003137_abnormal_impulse_conducting	0.84839974
82	MP0008995_early_reproductive_senescence	0.83266584
83	MP0006138_congestive_heart_failure	0.80530724
84	MP0002572_abnormal_emotion/affect_behav	0.79612445
85	MP0002166_altered_tumor_susceptibility	0.78947244
86	MP0005620_abnormal_muscle_contractility	0.78286383
87	MP0003890_abnormal_embryonic-extraembry	0.78233687
88	MP0001905_abnormal_dopamine_level	0.77940930
89	MP0003828_pulmonary_edema	0.77268387
90	MP0001661_extended_life_span	0.75482483
91	MP0002067_abnormal_sensory_capabilities	0.74864234
92	MP0009745_abnormal_behavioral_response	0.74732193
93	MP0005332_abnormal_amino_acid	0.74324115
94	MP0002972_abnormal_cardiac_muscle	0.74025956
95	MP0001299_abnormal_eye_distance/	0.73981510
96	MP0002557_abnormal_social/conspecific_i	0.72795031
97	MP0005360_urolithiasis	0.72521786
98	MP0009764_decreased_sensitivity_to	0.70775147
99	MP0002118_abnormal_lipid_homeostasis	0.70250871
100	MP0001485_abnormal_pinna_reflex	0.70241617

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	4.00381126
2	Papillary thyroid carcinoma (HP:0002895)	3.76196752
3	Renal cortical cysts (HP:0000803)	3.70457747
4	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.44815991
5	Chronic hepatic failure (HP:0100626)	3.32953167
6	Abnormality of the renal cortex (HP:0011035)	3.32247356
7	Short tibia (HP:0005736)	3.12514553
8	Decreased circulating renin level (HP:0003351)	2.91888429
9	Medial flaring of the eyebrow (HP:0010747)	2.79465405
10	Papilledema (HP:0001085)	2.65669400
11	Congenital primary aphakia (HP:0007707)	2.64440001
12	Gait imbalance (HP:0002141)	2.57377548
13	Acanthocytosis (HP:0001927)	2.55002282
14	Nephronophthisis (HP:0000090)	2.46069621
15	Petechiae (HP:0000967)	2.45151737
16	Fibular aplasia (HP:0002990)	2.39616602
17	Pancreatic cysts (HP:0001737)	2.38864564
18	Hyperkalemia (HP:0002153)	2.37841646
19	Abnormality of the renal medulla (HP:0100957)	2.37696334
20	Nephrogenic diabetes insipidus (HP:0009806)	2.36377683
21	Hyperventilation (HP:0002883)	2.33897645
22	Febrile seizures (HP:0002373)	2.33459665
23	Facial diplegia (HP:0001349)	2.27302930
24	Thyroid carcinoma (HP:0002890)	2.25692644
25	Stomach cancer (HP:0012126)	2.25180329
26	Genital tract atresia (HP:0001827)	2.23743780
27	Poor coordination (HP:0002370)	2.21958964
28	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.20761081
29	Absent/shortened dynein arms (HP:0200106)	2.20761081
30	Insulin-resistant diabetes mellitus (HP:0000831)	2.17309124
31	Abnormal auditory evoked potentials (HP:0006958)	2.16619987
32	Metaphyseal dysplasia (HP:0100255)	2.15606904
33	Menorrhagia (HP:0000132)	2.15181633
34	Vaginal atresia (HP:0000148)	2.13299111
35	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.11936644
36	Abnormality of alanine metabolism (HP:0010916)	2.11936644
37	Hyperalaninemia (HP:0003348)	2.11936644
38	Fair hair (HP:0002286)	2.10484191
39	Thyroid-stimulating hormone excess (HP:0002925)	2.10353555
40	Broad-based gait (HP:0002136)	2.08900764
41	Abnormality of midbrain morphology (HP:0002418)	2.07684901
42	Molar tooth sign on MRI (HP:0002419)	2.07684901
43	Pancreatic fibrosis (HP:0100732)	2.06506454
44	Gaze-evoked nystagmus (HP:0000640)	2.04310186
45	Truncal obesity (HP:0001956)	2.03325574
46	Dyskinesia (HP:0100660)	2.02025953
47	Abnormality of renin-angiotensin system (HP:0000847)	2.01522617
48	Drooling (HP:0002307)	1.97616473
49	Genetic anticipation (HP:0003743)	1.94377870
50	Hypoplastic labia majora (HP:0000059)	1.93132253
51	Abnormality of the axillary hair (HP:0100134)	1.92618817
52	Abnormality of secondary sexual hair (HP:0009888)	1.92618817
53	Absent eyebrow (HP:0002223)	1.91855827
54	Atonic seizures (HP:0010819)	1.90593289
55	Anhidrosis (HP:0000970)	1.89652433
56	Epileptiform EEG discharges (HP:0011182)	1.89400841
57	EEG with generalized epileptiform discharges (HP:0011198)	1.88146137
58	Abnormality of potassium homeostasis (HP:0011042)	1.87974394
59	Hypsarrhythmia (HP:0002521)	1.87960762
60	Hypoplasia of the uterus (HP:0000013)	1.87442092
61	Generalized hypopigmentation of hair (HP:0011358)	1.86667834
62	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.83732433
63	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.83732433
64	Progressive cerebellar ataxia (HP:0002073)	1.81625750
65	Medulloblastoma (HP:0002885)	1.80764184
66	Increased mean platelet volume (HP:0011877)	1.78124664
67	Aplasia/hypoplasia of the uterus (HP:0008684)	1.78043651
68	Absent eyelashes (HP:0000561)	1.76431569
69	Increased circulating renin level (HP:0000848)	1.75301218
70	Colon cancer (HP:0003003)	1.75025767
71	Abnormality of the labia majora (HP:0012881)	1.74952859
72	True hermaphroditism (HP:0010459)	1.74583344
73	Prolonged bleeding time (HP:0003010)	1.74122385
74	Partial agenesis of the corpus callosum (HP:0001338)	1.73830857
75	Neoplasm of the heart (HP:0100544)	1.73174172
76	Poikilocytosis (HP:0004447)	1.70215637
77	Excessive salivation (HP:0003781)	1.68507938
78	Right ventricular cardiomyopathy (HP:0011663)	1.66265003
79	Absent speech (HP:0001344)	1.66091552
80	Inability to walk (HP:0002540)	1.65957758
81	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.65053909
82	Menstrual irregularities (HP:0000858)	1.64457769
83	Autoamputation (HP:0001218)	1.64308643
84	Neoplasm of the tracheobronchial system (HP:0100552)	1.64120007
85	Tubulointerstitial abnormality (HP:0001969)	1.63015737
86	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.62716687
87	Volvulus (HP:0002580)	1.62427868
88	Portal hypertension (HP:0001409)	1.62284129
89	Abolished electroretinogram (ERG) (HP:0000550)	1.62054381
90	Widely spaced teeth (HP:0000687)	1.61757823
91	Gingival bleeding (HP:0000225)	1.60515856
92	Hypokalemia (HP:0002900)	1.60204502
93	Increased density of long bones (HP:0006392)	1.60045040
94	Hyperaldosteronism (HP:0000859)	1.59768891
95	Clumsiness (HP:0002312)	1.57589231
96	Hyperactive renin-angiotensin system (HP:0000841)	1.55987236
97	Hepatoblastoma (HP:0002884)	1.55844358
98	Hypoalphalipoproteinemia (HP:0003233)	1.55630818
99	Asthma (HP:0002099)	1.55150909
100	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.54025845

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.82104023
2	MAP4K2	3.45293583
3	MAP3K4	3.40857060
4	AKT3	2.88875045
5	MAP2K7	2.62328234
6	FRK	2.39817601
7	EPHA3	2.33485898
8	ZAK	2.14521506
9	TLK1	2.09034236
10	STK39	1.94768893
11	MST4	1.91946331
12	CSNK1A1L	1.80611800
13	NUAK1	1.67130376
14	CAMK1G	1.58994778
15	CASK	1.58302020
16	WNK3	1.56678286
17	CSNK1G1	1.55756560
18	CSNK1G3	1.51791935
19	ACVR1B	1.50967971
20	BCR	1.48494880
21	SGK2	1.47073687
22	TIE1	1.46841821
23	PINK1	1.46497032
24	PIK3CG	1.37272963
25	CSNK1G2	1.34995800
26	FER	1.31924501
27	TXK	1.31336087
28	CAMKK2	1.30419461
29	OBSCN	1.29240812
30	ERBB3	1.27810712
31	BMPR1B	1.27798712
32	TEC	1.25460829
33	OXSR1	1.22243775
34	CAMK1D	1.21940590
35	WNK4	1.15234010
36	PIK3CA	1.14425048
37	MAPK13	1.09484010
38	PLK4	1.03824646
39	SGK223	1.00859571
40	SGK494	1.00859571
41	BRD4	1.00535851
42	BCKDK	0.99451925
43	NLK	0.99288258
44	TNIK	0.98336673
45	ADRBK2	0.95857720
46	CDK19	0.90059347
47	RPS6KA5	0.87919841
48	INSRR	0.87675308
49	GRK1	0.86630234
50	FLT3	0.84832091
51	VRK1	0.83047020
52	MYLK	0.82996893
53	TRIM28	0.80016056
54	BMPR2	0.75551166
55	PHKG1	0.73560654
56	PHKG2	0.73560654
57	PLK2	0.71530856
58	SGK3	0.71238820
59	MAP3K6	0.70472388
60	PRKAA2	0.70410256
61	GRK6	0.68591682
62	PRKCE	0.68446035
63	MAP2K4	0.66975672
64	MET	0.64239670
65	CAMK4	0.63998375
66	JAK1	0.63762681
67	PAK3	0.63262327
68	BRSK2	0.62760758
69	PTK2B	0.61209809
70	SCYL2	0.60176101
71	WNK1	0.59900977
72	PRKAA1	0.55536435
73	CAMK1	0.55533318
74	SRPK1	0.54330105
75	MARK1	0.52343426
76	MUSK	0.51672521
77	PKN1	0.46178305
78	MAP3K5	0.45973521
79	MAPKAPK5	0.45883720
80	NTRK3	0.44528476
81	PRKG1	0.44385765
82	PIM1	0.42369419
83	CAMK2A	0.41425465
84	NEK1	0.41258136
85	DAPK2	0.39566057
86	STK38	0.38859124
87	SGK1	0.37988070
88	IGF1R	0.35926675
89	IKBKE	0.35541965
90	CSNK1D	0.34941630
91	CDK3	0.34764730
92	PRKACB	0.34489352
93	GRK7	0.34368637
94	STK38L	0.34209723
95	ADRBK1	0.34194130
96	TESK1	0.34107100
97	PRKACA	0.33335076
98	LATS1	0.33066544
99	ERBB2	0.32349173
100	CSNK1A1	0.32162363

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Circadian rhythm_Homo sapiens_hsa04710	2.94719570
2	Alcoholism_Homo sapiens_hsa05034	2.45944723
3	Sulfur metabolism_Homo sapiens_hsa00920	2.45202886
4	Nicotine addiction_Homo sapiens_hsa05033	2.41592975
5	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.40879666
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.34694610
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.24254378
8	Fat digestion and absorption_Homo sapiens_hsa04975	1.91065353
9	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.78720727
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.76731640
11	Nitrogen metabolism_Homo sapiens_hsa00910	1.73689747
12	Caffeine metabolism_Homo sapiens_hsa00232	1.60413295
13	Morphine addiction_Homo sapiens_hsa05032	1.59825693
14	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.54356051
15	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.53794205
16	GABAergic synapse_Homo sapiens_hsa04727	1.53086744
17	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.52656080
18	Taste transduction_Homo sapiens_hsa04742	1.51869421
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.51318149
20	Salivary secretion_Homo sapiens_hsa04970	1.49384369
21	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.46922342
22	Regulation of autophagy_Homo sapiens_hsa04140	1.43929909
23	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.43827628
24	Fatty acid elongation_Homo sapiens_hsa00062	1.42602458
25	Renin-angiotensin system_Homo sapiens_hsa04614	1.41615807
26	Serotonergic synapse_Homo sapiens_hsa04726	1.41402533
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.38421634
28	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.37035681
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.34988505
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.32684045
31	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.30494801
32	Chemical carcinogenesis_Homo sapiens_hsa05204	1.24633645
33	Collecting duct acid secretion_Homo sapiens_hsa04966	1.23668520
34	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.22985381
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.21778782
36	Circadian entrainment_Homo sapiens_hsa04713	1.20323710
37	Olfactory transduction_Homo sapiens_hsa04740	1.20210297
38	Phototransduction_Homo sapiens_hsa04744	1.15043650
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.12670759
40	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.09926642
41	Pancreatic secretion_Homo sapiens_hsa04972	1.09508926
42	Butanoate metabolism_Homo sapiens_hsa00650	1.09076692
43	Steroid biosynthesis_Homo sapiens_hsa00100	1.08704357
44	Insulin secretion_Homo sapiens_hsa04911	1.08316479
45	Peroxisome_Homo sapiens_hsa04146	1.04183327
46	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.02231346
47	Amphetamine addiction_Homo sapiens_hsa05031	1.02117779
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.00790320
49	Propanoate metabolism_Homo sapiens_hsa00640	1.00499809
50	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.00308104
51	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.98273853
52	Retinol metabolism_Homo sapiens_hsa00830	0.97763397
53	ABC transporters_Homo sapiens_hsa02010	0.93781593
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.92084862
55	Oxidative phosphorylation_Homo sapiens_hsa00190	0.90688959
56	Sphingolipid metabolism_Homo sapiens_hsa00600	0.90493710
57	Renin secretion_Homo sapiens_hsa04924	0.87802377
58	Platelet activation_Homo sapiens_hsa04611	0.86546365
59	Dopaminergic synapse_Homo sapiens_hsa04728	0.85261864
60	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.83981699
61	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.82322477
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.78859732
63	Cardiac muscle contraction_Homo sapiens_hsa04260	0.76149913
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.75701205
65	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.74277361
66	Fatty acid metabolism_Homo sapiens_hsa01212	0.70610585
67	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.67759732
68	Glutamatergic synapse_Homo sapiens_hsa04724	0.67393944
69	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.67264439
70	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.66615697
71	Fanconi anemia pathway_Homo sapiens_hsa03460	0.66418529
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.65957541
73	Huntingtons disease_Homo sapiens_hsa05016	0.64059578
74	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.62546110
75	cAMP signaling pathway_Homo sapiens_hsa04024	0.62202852
76	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.59472771
77	RNA degradation_Homo sapiens_hsa03018	0.59226473
78	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.58778331
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.58313338
80	Mineral absorption_Homo sapiens_hsa04978	0.56156711
81	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.56135017
82	Long-term depression_Homo sapiens_hsa04730	0.56015132
83	Parkinsons disease_Homo sapiens_hsa05012	0.53089953
84	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.52909085
85	Protein export_Homo sapiens_hsa03060	0.52747815
86	Basal transcription factors_Homo sapiens_hsa03022	0.51397943
87	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.48645375
88	Histidine metabolism_Homo sapiens_hsa00340	0.46229844
89	Viral carcinogenesis_Homo sapiens_hsa05203	0.44050646
90	Cocaine addiction_Homo sapiens_hsa05030	0.43769326
91	Alzheimers disease_Homo sapiens_hsa05010	0.43727366
92	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.42751438
93	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.41969251
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41031166
95	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.39437752
96	PPAR signaling pathway_Homo sapiens_hsa03320	0.38001423
97	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.36807007
98	Adherens junction_Homo sapiens_hsa04520	0.36737213
99	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.35595450
100	Vibrio cholerae infection_Homo sapiens_hsa05110	0.35503118

MTRNR2L10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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