ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	7.29821520
2	acrosome reaction (GO:0007340)	6.77617961
3	fusion of sperm to egg plasma membrane (GO:0007342)	6.61258290
4	sperm capacitation (GO:0048240)	5.93328820
5	establishment of protein localization to Golgi (GO:0072600)	5.60864008
6	protein targeting to Golgi (GO:0000042)	5.35353424
7	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.25416247
8	microtubule depolymerization (GO:0007019)	5.00512379
9	plasma membrane fusion (GO:0045026)	4.94921020
10	DNA packaging (GO:0006323)	4.73556607
11	microtubule polymerization or depolymerization (GO:0031109)	4.72440131
12	single strand break repair (GO:0000012)	4.70346469
13	spermatid development (GO:0007286)	4.69964752
14	calcium ion-dependent exocytosis (GO:0017156)	4.64549645
15	chromosome condensation (GO:0030261)	4.43806795
16	response to pheromone (GO:0019236)	4.37375545
17	Golgi to endosome transport (GO:0006895)	4.28157398
18	protein polyglutamylation (GO:0018095)	4.27905385
19	sexual reproduction (GO:0019953)	4.27895146
20	spermatid nucleus differentiation (GO:0007289)	4.24378175
21	multicellular organism reproduction (GO:0032504)	4.14729073
22	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.13643097
23	negative regulation of inclusion body assembly (GO:0090084)	4.07382732
24	positive regulation of Rab GTPase activity (GO:0032851)	4.04867912
25	regulation of Rab GTPase activity (GO:0032313)	4.04867912
26	reproduction (GO:0000003)	4.01807615
27	musculoskeletal movement (GO:0050881)	3.99537206
28	multicellular organismal movement (GO:0050879)	3.99537206
29	microtubule severing (GO:0051013)	3.85147654
30	phosphatidylethanolamine metabolic process (GO:0046337)	3.80145582
31	regulation of transcription involved in cell fate commitment (GO:0060850)	3.67927822
32	sperm-egg recognition (GO:0035036)	3.65947238
33	nuclear pore complex assembly (GO:0051292)	3.61119987
34	protein localization to Golgi apparatus (GO:0034067)	3.60200067
35	spermatogenesis (GO:0007283)	3.50404460
36	male gamete generation (GO:0048232)	3.49773340
37	cilium or flagellum-dependent cell motility (GO:0001539)	3.43918406
38	centriole replication (GO:0007099)	3.28668114
39	regulation of bile acid biosynthetic process (GO:0070857)	3.24766101
40	gamete generation (GO:0007276)	3.22124361
41	receptor recycling (GO:0001881)	3.18999767
42	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.18113220
43	regulation of centriole replication (GO:0046599)	3.17626694
44	regulation of cilium movement (GO:0003352)	3.11038253
45	centrosome duplication (GO:0051298)	3.07869229
46	nucleus organization (GO:0006997)	3.07369240
47	peptidyl-threonine dephosphorylation (GO:0035970)	3.04104065
48	cell-cell recognition (GO:0009988)	3.01625890
49	positive regulation of guanylate cyclase activity (GO:0031284)	3.00590022
50	genitalia morphogenesis (GO:0035112)	2.94323713
51	negative regulation of vascular permeability (GO:0043116)	2.94004187
52	coenzyme catabolic process (GO:0009109)	2.93717739
53	axonemal dynein complex assembly (GO:0070286)	2.93149419
54	histone H3-K9 demethylation (GO:0033169)	2.91131728
55	regulation of guanylate cyclase activity (GO:0031282)	2.90943150
56	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.89895870
57	motile cilium assembly (GO:0044458)	2.88746211
58	binding of sperm to zona pellucida (GO:0007339)	2.86989208
59	protein K48-linked deubiquitination (GO:0071108)	2.83672273
60	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.82858781
61	cellular ketone body metabolic process (GO:0046950)	2.81999567
62	nuclear pore organization (GO:0006999)	2.81988132
63	vesicle transport along microtubule (GO:0047496)	2.80029728
64	germ cell development (GO:0007281)	2.79240609
65	L-amino acid import (GO:0043092)	2.75276061
66	microtubule nucleation (GO:0007020)	2.74464194
67	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.74449342
68	pore complex assembly (GO:0046931)	2.70635869
69	RNA destabilization (GO:0050779)	2.68400525
70	lipoprotein transport (GO:0042953)	2.67771946
71	C4-dicarboxylate transport (GO:0015740)	2.66816982
72	interkinetic nuclear migration (GO:0022027)	2.65739214
73	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.65554435
74	multicellular organismal reproductive process (GO:0048609)	2.64465909
75	rRNA methylation (GO:0031167)	2.64464923
76	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.64424055
77	angiotensin maturation (GO:0002003)	2.62081451
78	chromatin silencing (GO:0006342)	2.62031358
79	centriole assembly (GO:0098534)	2.61086508
80	organic cation transport (GO:0015695)	2.59899426
81	carnitine shuttle (GO:0006853)	2.58808443
82	artery development (GO:0060840)	2.58512046
83	single fertilization (GO:0007338)	2.55611293
84	positive regulation of endothelial cell differentiation (GO:0045603)	2.52848597
85	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.51355760
86	sleep (GO:0030431)	2.51260197
87	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.48225974
88	regulation of inclusion body assembly (GO:0090083)	2.46723653
89	sodium ion export (GO:0071436)	2.46283343
90	ketone body metabolic process (GO:1902224)	2.45337241
91	primary amino compound metabolic process (GO:1901160)	2.42135098
92	regulation of interleukin-13 production (GO:0032656)	2.39364053
93	positive regulation of glycolytic process (GO:0045821)	2.39214247
94	alanine transport (GO:0032328)	2.36119210
95	membrane depolarization during action potential (GO:0086010)	2.35445701
96	early endosome to late endosome transport (GO:0045022)	2.34377816
97	negative regulation of Rho protein signal transduction (GO:0035024)	2.34174182
98	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.33727000
99	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.32982477
100	intra-Golgi vesicle-mediated transport (GO:0006891)	2.32867642

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.44261398
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.53095289
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.23068037
4	AR_21572438_ChIP-Seq_LNCaP_Human	2.17577291
5	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.99446549
6	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.98330892
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.88012420
8	SMAD4_21799915_ChIP-Seq_A2780_Human	1.87586461
9	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.87005344
10	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.86423803
11	DROSHA_22980978_ChIP-Seq_HELA_Human	1.83762061
12	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.80518115
13	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.80518115
14	TAF15_26573619_Chip-Seq_HEK293_Human	1.79850047
15	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.78992701
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.76411763
17	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.71590508
18	STAT3_23295773_ChIP-Seq_U87_Human	1.70898039
19	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.70869502
20	CBP_20019798_ChIP-Seq_JUKART_Human	1.70869502
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68276654
22	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.68014303
23	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.67806915
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.67505054
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.67281370
26	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.66906705
27	FUS_26573619_Chip-Seq_HEK293_Human	1.59299176
28	P300_19829295_ChIP-Seq_ESCs_Human	1.58572761
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56281147
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54327294
31	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.50341963
32	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.49250126
33	TCF4_23295773_ChIP-Seq_U87_Human	1.48844471
34	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.48354079
35	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.47110467
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44676753
37	AR_25329375_ChIP-Seq_VCAP_Human	1.42572093
38	AHR_22903824_ChIP-Seq_MCF-7_Human	1.37287737
39	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.29150731
40	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.29024446
41	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.27597439
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.27110097
43	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.24916335
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.24118205
45	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.23691654
46	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23253933
47	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22963176
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.21226003
49	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.20559457
50	TBL1_22424771_ChIP-Seq_293T_Human	1.19594281
51	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.18699817
52	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.17023240
53	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.15529062
54	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15391086
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14369508
56	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13947513
57	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.13942461
58	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.11899947
59	TP53_18474530_ChIP-ChIP_U2OS_Human	1.11100911
60	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.10669838
61	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.10571320
62	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.09618473
63	GATA1_22025678_ChIP-Seq_K562_Human	1.08776782
64	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.07593161
65	RUNX2_22187159_ChIP-Seq_PCA_Human	1.07114908
66	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.05151721
67	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.03779363
68	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.03656912
69	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02862204
70	NFYB_21822215_ChIP-Seq_K562_Human	1.02593808
71	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.02289469
72	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.02284041
73	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.01215361
74	CDX2_22108803_ChIP-Seq_LS180_Human	1.01032972
75	RXR_22108803_ChIP-Seq_LS180_Human	1.00166138
76	GF1_26923725_Chip-Seq_HPCs_Mouse	1.00104325
77	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.99829244
78	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.99404382
79	TP63_23658742_ChIP-Seq_EP156T_Human	0.98189540
80	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97723314
81	AR_19668381_ChIP-Seq_PC3_Human	0.96643675
82	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.96571533
83	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.95505171
84	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.94672326
85	KDM2B_26808549_Chip-Seq_REH_Human	0.93660417
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.93221710
87	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.93204479
88	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.93117464
89	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.92420886
90	NANOG_19829295_ChIP-Seq_ESCs_Human	0.91512728
91	SOX2_19829295_ChIP-Seq_ESCs_Human	0.91512728
92	ETV1_20927104_ChIP-Seq_GIST48_Human	0.91031441
93	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.90370477
94	NFYA_21822215_ChIP-Seq_K562_Human	0.90195036
95	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.89836780
96	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.89160782
97	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.88486810
98	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.88483975
99	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.88117214
100	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.87918659

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	7.26358491
2	MP0005670_abnormal_white_adipose	5.08238927
3	MP0003646_muscle_fatigue	2.79537953
4	MP0003698_abnormal_male_reproductive	2.74707848
5	MP0005377_hearing/vestibular/ear_phenot	2.58855819
6	MP0003878_abnormal_ear_physiology	2.58855819
7	MP0001666_abnormal_nutrient_absorption	2.26074561
8	MP0003879_abnormal_hair_cell	2.24267759
9	MP0004270_analgesia	2.22461409
10	MP0001929_abnormal_gametogenesis	2.22413473
11	MP0004859_abnormal_synaptic_plasticity	2.20391630
12	MP0005409_darkened_coat_color	2.16256932
13	MP0002822_catalepsy	2.11668984
14	MP0004036_abnormal_muscle_relaxation	2.09000878
15	MP0000569_abnormal_digit_pigmentation	2.07187318
16	MP0004130_abnormal_muscle_cell	2.01402609
17	MP0005666_abnormal_adipose_tissue	2.00057033
18	MP0005085_abnormal_gallbladder_physiolo	1.94517649
19	MP0001486_abnormal_startle_reflex	1.93113726
20	MP0003718_maternal_effect	1.88716009
21	MP0009697_abnormal_copulation	1.86147033
22	MP0003183_abnormal_peptide_metabolism	1.81365115
23	MP0003941_abnormal_skin_development	1.75098570
24	MP0001501_abnormal_sleep_pattern	1.71474362
25	MP0004084_abnormal_cardiac_muscle	1.70963439
26	MP0005083_abnormal_biliary_tract	1.58439496
27	MP0005365_abnormal_bile_salt	1.57945528
28	MP0010329_abnormal_lipoprotein_level	1.57713601
29	MP0009780_abnormal_chondrocyte_physiolo	1.51871043
30	MP0009046_muscle_twitch	1.50794759
31	MP0008057_abnormal_DNA_replication	1.50511951
32	MP0004264_abnormal_extraembryonic_tissu	1.50090470
33	MP0002009_preneoplasia	1.47907852
34	MP0002161_abnormal_fertility/fecundity	1.47403427
35	MP0009115_abnormal_fat_cell	1.44518114
36	MP0004147_increased_porphyrin_level	1.39759583
37	MP0001765_abnormal_ion_homeostasis	1.37738264
38	MP0008569_lethality_at_weaning	1.33155994
39	MP0004484_altered_response_of	1.29866716
40	MP0001879_abnormal_lymphatic_vessel	1.29590654
41	MP0002064_seizures	1.27890130
42	MP0005375_adipose_tissue_phenotype	1.27234551
43	MP0004233_abnormal_muscle_weight	1.23659565
44	MP0010352_gastrointestinal_tract_polyps	1.20516306
45	MP0005360_urolithiasis	1.19508429
46	MP0002272_abnormal_nervous_system	1.18386736
47	MP0003635_abnormal_synaptic_transmissio	1.17911685
48	MP0003868_abnormal_feces_composition	1.17705118
49	MP0001485_abnormal_pinna_reflex	1.15692619
50	MP0002971_abnormal_brown_adipose	1.14383553
51	MP0002557_abnormal_social/conspecific_i	1.10772155
52	MP0005646_abnormal_pituitary_gland	1.10643839
53	MP0004085_abnormal_heartbeat	1.10219421
54	MP0008004_abnormal_stomach_pH	1.07734996
55	MP0005535_abnormal_body_temperature	1.05575051
56	MP0002734_abnormal_mechanical_nocicepti	1.02686471
57	MP0002735_abnormal_chemical_nociception	1.02606597
58	MP0001440_abnormal_grooming_behavior	1.00834735
59	MP0009745_abnormal_behavioral_response	1.00834155
60	MP0004145_abnormal_muscle_electrophysio	1.00592159
61	MP0004510_myositis	0.97387088
62	MP0006138_congestive_heart_failure	0.97122877
63	MP0002572_abnormal_emotion/affect_behav	0.96671876
64	MP0001661_extended_life_span	0.93584548
65	MP0003950_abnormal_plasma_membrane	0.90822717
66	MP0002067_abnormal_sensory_capabilities	0.90761462
67	MP0002876_abnormal_thyroid_physiology	0.90553585
68	MP0003633_abnormal_nervous_system	0.90421250
69	MP0005423_abnormal_somatic_nervous	0.89935119
70	MP0002063_abnormal_learning/memory/cond	0.88162216
71	MP0005167_abnormal_blood-brain_barrier	0.87281089
72	MP0003045_fibrosis	0.87078622
73	MP0000534_abnormal_ureter_morphology	0.87007612
74	MP0004215_abnormal_myocardial_fiber	0.85939191
75	MP0000230_abnormal_systemic_arterial	0.85664387
76	MP0005636_abnormal_mineral_homeostasis	0.85664013
77	MP0000003_abnormal_adipose_tissue	0.85087494
78	MP0005551_abnormal_eye_electrophysiolog	0.82644299
79	MP0003631_nervous_system_phenotype	0.82458639
80	MP0004924_abnormal_behavior	0.80577388
81	MP0005386_behavior/neurological_phenoty	0.80577388
82	MP0001963_abnormal_hearing_physiology	0.80395513
83	MP0002118_abnormal_lipid_homeostasis	0.79924121
84	MP0005395_other_phenotype	0.79086626
85	MP0001348_abnormal_lacrimal_gland	0.78317099
86	MP0002127_abnormal_cardiovascular_syste	0.77365829
87	MP0002210_abnormal_sex_determination	0.77191405
88	MP0005448_abnormal_energy_balance	0.75892942
89	MP0002229_neurodegeneration	0.75097003
90	MP0004134_abnormal_chest_morphology	0.74564875
91	MP0005332_abnormal_amino_acid	0.73763508
92	MP0002733_abnormal_thermal_nociception	0.73602534
93	MP0001299_abnormal_eye_distance/	0.73192358
94	MP0001968_abnormal_touch/_nociception	0.71858511
95	MP0005451_abnormal_body_composition	0.70902014
96	MP0005620_abnormal_muscle_contractility	0.70396085
97	MP0003632_abnormal_nervous_system	0.69917846
98	MP0002234_abnormal_pharynx_morphology	0.67291043
99	MP0000653_abnormal_sex_gland	0.66352887
100	MP0001145_abnormal_male_reproductive	0.65575568

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperkalemia (HP:0002153)	4.91729855
2	Tubulointerstitial nephritis (HP:0001970)	4.24283391
3	Abnormality of the ischium (HP:0003174)	3.93155978
4	Potter facies (HP:0002009)	3.86390341
5	Facial shape deformation (HP:0011334)	3.86390341
6	Bell-shaped thorax (HP:0001591)	3.51084944
7	Chronic hepatic failure (HP:0100626)	3.50767294
8	Progressive cerebellar ataxia (HP:0002073)	3.50581138
9	Asymmetric septal hypertrophy (HP:0001670)	3.46764957
10	Hypoplastic ischia (HP:0003175)	3.45189920
11	Impulsivity (HP:0100710)	3.41623229
12	Enlarged epiphyses (HP:0010580)	3.35671452
13	Acanthocytosis (HP:0001927)	3.30810528
14	Severe visual impairment (HP:0001141)	3.24973678
15	Truncal obesity (HP:0001956)	3.19507425
16	Hypoalphalipoproteinemia (HP:0003233)	3.12978472
17	Abnormality of potassium homeostasis (HP:0011042)	3.11689464
18	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.99186860
19	Absent/shortened dynein arms (HP:0200106)	2.99186860
20	Postural instability (HP:0002172)	2.97902678
21	Genetic anticipation (HP:0003743)	2.92001546
22	Male infertility (HP:0003251)	2.86715174
23	Cone-rod dystrophy (HP:0000548)	2.85541669
24	Insulin-resistant diabetes mellitus (HP:0000831)	2.83636187
25	Abnormality of the fingertips (HP:0001211)	2.80381021
26	Papillary thyroid carcinoma (HP:0002895)	2.72741626
27	Hypophosphatemic rickets (HP:0004912)	2.63204009
28	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.63080917
29	Abnormality of the pubic bones (HP:0003172)	2.57399231
30	Hypolipoproteinemia (HP:0010981)	2.55988806
31	Renovascular hypertension (HP:0100817)	2.54966732
32	Febrile seizures (HP:0002373)	2.51164630
33	Osteomalacia (HP:0002749)	2.46371312
34	Infertility (HP:0000789)	2.36897361
35	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.36676485
36	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.36468820
37	Neoplasm of the heart (HP:0100544)	2.36068446
38	Gaze-evoked nystagmus (HP:0000640)	2.35964871
39	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.35363316
40	Right ventricular cardiomyopathy (HP:0011663)	2.33590960
41	Ventricular tachycardia (HP:0004756)	2.32312845
42	Atonic seizures (HP:0010819)	2.30842483
43	Menstrual irregularities (HP:0000858)	2.29574810
44	Bony spicule pigmentary retinopathy (HP:0007737)	2.23619983
45	Abnormality of macular pigmentation (HP:0008002)	2.23330872
46	Midline defect of the nose (HP:0004122)	2.18112342
47	Double outlet right ventricle (HP:0001719)	2.16454381
48	Congenital malformation of the right heart (HP:0011723)	2.16454381
49	Abnormal spermatogenesis (HP:0008669)	2.15958525
50	Increased purine levels (HP:0004368)	2.14559380
51	Hyperuricemia (HP:0002149)	2.14559380
52	Sudden death (HP:0001699)	2.14435197
53	Acute myeloid leukemia (HP:0004808)	2.12028992
54	Portal hypertension (HP:0001409)	2.11935015
55	Bundle branch block (HP:0011710)	2.10691154
56	Tubulointerstitial abnormality (HP:0001969)	2.09429604
57	Subaortic stenosis (HP:0001682)	2.08999915
58	Abnormality of the left ventricular outflow tract (HP:0011103)	2.08999915
59	Widely patent fontanelles and sutures (HP:0004492)	2.07978295
60	Abnormal ciliary motility (HP:0012262)	2.07356179
61	Poikilocytosis (HP:0004447)	2.05388441
62	Azoospermia (HP:0000027)	2.04626974
63	Attenuation of retinal blood vessels (HP:0007843)	2.04217383
64	Neonatal hypoglycemia (HP:0001998)	2.03482851
65	Hypokalemia (HP:0002900)	2.03036224
66	Overgrowth (HP:0001548)	2.00603168
67	Myokymia (HP:0002411)	2.00519136
68	Pigmentary retinal degeneration (HP:0001146)	1.96828527
69	Dysmetric saccades (HP:0000641)	1.95583286
70	Termporal pattern (HP:0011008)	1.91620671
71	Insidious onset (HP:0003587)	1.91620671
72	Increased circulating renin level (HP:0000848)	1.89525050
73	Abnormal respiratory motile cilium physiology (HP:0012261)	1.88427255
74	Abnormality of the hepatic vasculature (HP:0006707)	1.86070368
75	Abnormality of the parathyroid morphology (HP:0011766)	1.85730105
76	Hyperactive renin-angiotensin system (HP:0000841)	1.82930670
77	Neoplasm of striated muscle (HP:0009728)	1.82334879
78	Abnormality of chloride homeostasis (HP:0011422)	1.78471957
79	Sandal gap (HP:0001852)	1.78057487
80	Spontaneous abortion (HP:0005268)	1.77606863
81	Accelerated skeletal maturation (HP:0005616)	1.77036980
82	Abnormality of the nasal septum (HP:0000419)	1.76973985
83	Myoglobinuria (HP:0002913)	1.76905458
84	Hyperventilation (HP:0002883)	1.76131309
85	Action tremor (HP:0002345)	1.75872892
86	Syncope (HP:0001279)	1.70362155
87	Resting tremor (HP:0002322)	1.68913826
88	Abnormality of the aortic arch (HP:0012303)	1.68794764
89	Hyperaldosteronism (HP:0000859)	1.66555947
90	Absent eyebrow (HP:0002223)	1.66172556
91	Urinary bladder sphincter dysfunction (HP:0002839)	1.64914736
92	Rhabdomyolysis (HP:0003201)	1.64833299
93	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.64213963
94	Hypoplasia of the thymus (HP:0000778)	1.63784084
95	Skin pits (HP:0100276)	1.63605712
96	Germ cell neoplasia (HP:0100728)	1.63599279
97	Abnormality of the parietal bone (HP:0002696)	1.63292508
98	Rhinitis (HP:0012384)	1.62809739
99	Abnormal respiratory epithelium morphology (HP:0012253)	1.61327702
100	Abnormal respiratory motile cilium morphology (HP:0005938)	1.61327702

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	4.36344832
2	CAMK1G	3.72644604
3	AKT3	3.39744927
4	CAMK1D	2.87092295
5	STK38	2.67932205
6	STK39	2.62324462
7	DDR2	2.38560996
8	PIK3CG	2.27250191
9	TESK1	2.25828791
10	CDK12	2.10381083
11	ACVR1B	2.03929788
12	ZAK	2.02148474
13	INSRR	1.87826448
14	BRD4	1.85880993
15	SGK2	1.84991866
16	TLK1	1.83367276
17	OBSCN	1.80294055
18	PLK2	1.77812900
19	PRKD3	1.76977679
20	WNK1	1.66510125
21	SGK223	1.60560539
22	SGK494	1.60560539
23	STK38L	1.55450064
24	FRK	1.53981627
25	NTRK3	1.47069050
26	PNCK	1.40453774
27	MAP3K4	1.39786897
28	LATS1	1.36543980
29	MAP3K2	1.34568922
30	CASK	1.31868343
31	MST1R	1.30611304
32	SGK3	1.29955991
33	NEK6	1.27979470
34	NLK	1.25793198
35	PDK1	1.23952603
36	PRKAA2	1.23569563
37	CAMK1	1.18006996
38	OXSR1	1.11485275
39	PDPK1	1.09262987
40	WNK4	1.01920845
41	MET	1.00813589
42	RIPK4	1.00556662
43	MAP4K2	1.00022734
44	CAMK4	0.96141908
45	MARK2	0.92951209
46	TNIK	0.90193980
47	BMPR2	0.90119610
48	SGK1	0.87993461
49	PRKAA1	0.85335496
50	FER	0.84757186
51	RIPK1	0.73549581
52	PRKG1	0.71985639
53	TAOK3	0.71891036
54	BMPR1B	0.67734103
55	PKN1	0.64314278
56	TYRO3	0.60682878
57	PIK3CA	0.58807416
58	MAPK15	0.58491864
59	SCYL2	0.57767090
60	MUSK	0.55569727
61	MAPK10	0.54926229
62	TEC	0.53349982
63	GSK3B	0.52138912
64	RPS6KA5	0.52057894
65	ICK	0.51421496
66	MTOR	0.50273993
67	RPS6KA3	0.50207596
68	CDK7	0.48067091
69	DYRK1B	0.46407401
70	DMPK	0.46026443
71	PHKG1	0.45594827
72	PHKG2	0.45594827
73	ROCK1	0.45207819
74	PRKCB	0.44462188
75	PINK1	0.43095972
76	NUAK1	0.42850894
77	PRKG2	0.42836353
78	CDK5	0.42706932
79	MAP2K7	0.42032666
80	BRAF	0.41515113
81	STK11	0.41490412
82	CSNK1A1L	0.39919359
83	KSR2	0.39229006
84	LMTK2	0.37781784
85	CAMKK2	0.37415635
86	PIM1	0.36992397
87	MELK	0.36967765
88	MAPK14	0.36550358
89	EPHA4	0.36434292
90	RET	0.36380156
91	MAPK11	0.35974248
92	RPS6KA2	0.35889209
93	BRSK2	0.35543759
94	JAK1	0.35424439
95	MARK1	0.35335268
96	CDK3	0.34776942
97	PTK2B	0.34571547
98	MAPK1	0.34398813
99	STK3	0.33639915
100	CAMK2A	0.33563351

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	4.51283100
2	Alcoholism_Homo sapiens_hsa05034	2.36363497
3	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.33583020
4	Renin-angiotensin system_Homo sapiens_hsa04614	2.17925541
5	Fat digestion and absorption_Homo sapiens_hsa04975	1.97391008
6	Olfactory transduction_Homo sapiens_hsa04740	1.86007409
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.76281428
8	PPAR signaling pathway_Homo sapiens_hsa03320	1.65722941
9	Nicotine addiction_Homo sapiens_hsa05033	1.64691068
10	Protein digestion and absorption_Homo sapiens_hsa04974	1.63286099
11	Arginine biosynthesis_Homo sapiens_hsa00220	1.61051330
12	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.58498806
13	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.57126413
14	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.38458084
15	Fatty acid metabolism_Homo sapiens_hsa01212	1.35999959
16	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.30462966
17	Circadian entrainment_Homo sapiens_hsa04713	1.28791839
18	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.28105458
19	Long-term potentiation_Homo sapiens_hsa04720	1.26699660
20	Fatty acid degradation_Homo sapiens_hsa00071	1.23871932
21	Salivary secretion_Homo sapiens_hsa04970	1.22979171
22	Morphine addiction_Homo sapiens_hsa05032	1.22837195
23	Circadian rhythm_Homo sapiens_hsa04710	1.22107942
24	Bile secretion_Homo sapiens_hsa04976	1.22009228
25	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.21676881
26	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.20068440
27	Pancreatic secretion_Homo sapiens_hsa04972	1.19225383
28	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.18418514
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.18411181
30	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.16310382
31	Type II diabetes mellitus_Homo sapiens_hsa04930	1.14414682
32	Insulin secretion_Homo sapiens_hsa04911	1.13478050
33	Renin secretion_Homo sapiens_hsa04924	1.12873235
34	Amphetamine addiction_Homo sapiens_hsa05031	1.12458489
35	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.11857385
36	Calcium signaling pathway_Homo sapiens_hsa04020	1.11106294
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.10981156
38	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.10526648
39	Phenylalanine metabolism_Homo sapiens_hsa00360	1.09515716
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.08782410
41	Taste transduction_Homo sapiens_hsa04742	1.08127439
42	Glutamatergic synapse_Homo sapiens_hsa04724	1.06785694
43	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.06652928
44	Glycerolipid metabolism_Homo sapiens_hsa00561	1.03898072
45	Adherens junction_Homo sapiens_hsa04520	1.03043784
46	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.01463117
47	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.01117022
48	Serotonergic synapse_Homo sapiens_hsa04726	1.00674076
49	Caffeine metabolism_Homo sapiens_hsa00232	1.00178053
50	ABC transporters_Homo sapiens_hsa02010	0.99816556
51	cAMP signaling pathway_Homo sapiens_hsa04024	0.98073028
52	Mineral absorption_Homo sapiens_hsa04978	0.96940510
53	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.95446014
54	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.94502326
55	GABAergic synapse_Homo sapiens_hsa04727	0.90752464
56	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.90468951
57	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.90187563
58	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.90140659
59	Gastric acid secretion_Homo sapiens_hsa04971	0.89619803
60	Cholinergic synapse_Homo sapiens_hsa04725	0.87810213
61	Tight junction_Homo sapiens_hsa04530	0.87293534
62	Linoleic acid metabolism_Homo sapiens_hsa00591	0.85669784
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84883440
64	Platelet activation_Homo sapiens_hsa04611	0.82049971
65	Retinol metabolism_Homo sapiens_hsa00830	0.81020638
66	Histidine metabolism_Homo sapiens_hsa00340	0.80771718
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.78566572
68	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.78322646
69	Arginine and proline metabolism_Homo sapiens_hsa00330	0.75290741
70	Sphingolipid metabolism_Homo sapiens_hsa00600	0.74318610
71	Butanoate metabolism_Homo sapiens_hsa00650	0.72994653
72	Dopaminergic synapse_Homo sapiens_hsa04728	0.72086950
73	Cocaine addiction_Homo sapiens_hsa05030	0.71425475
74	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.71327524
75	Insulin resistance_Homo sapiens_hsa04931	0.70114876
76	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.69867081
77	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.65553249
78	Glioma_Homo sapiens_hsa05214	0.64888292
79	Viral carcinogenesis_Homo sapiens_hsa05203	0.64738998
80	ECM-receptor interaction_Homo sapiens_hsa04512	0.64391171
81	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.62916115
82	ErbB signaling pathway_Homo sapiens_hsa04012	0.62349052
83	Choline metabolism in cancer_Homo sapiens_hsa05231	0.62281629
84	Lysine degradation_Homo sapiens_hsa00310	0.60356620
85	Long-term depression_Homo sapiens_hsa04730	0.58995968
86	Chemical carcinogenesis_Homo sapiens_hsa05204	0.58608033
87	Glucagon signaling pathway_Homo sapiens_hsa04922	0.57306493
88	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.56453113
89	Nitrogen metabolism_Homo sapiens_hsa00910	0.55005572
90	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.53453025
91	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.52057565
92	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.51236634
93	Insulin signaling pathway_Homo sapiens_hsa04910	0.50769630
94	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.50275882
95	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.49052255
96	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.49045756
97	Gap junction_Homo sapiens_hsa04540	0.47754475
98	Estrogen signaling pathway_Homo sapiens_hsa04915	0.47706545
99	Prolactin signaling pathway_Homo sapiens_hsa04917	0.47678073
100	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46108092

MTRNR2L11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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