ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	microtubule depolymerization (GO:0007019)	3.28282514
2	pyrimidine nucleobase catabolic process (GO:0006208)	3.23206238
3	establishment of protein localization to Golgi (GO:0072600)	3.19200720
4	nuclear pore complex assembly (GO:0051292)	3.02702927
5	microtubule polymerization or depolymerization (GO:0031109)	3.01413375
6	microtubule anchoring (GO:0034453)	2.99044741
7	intraciliary transport (GO:0042073)	2.92090210
8	nucleobase catabolic process (GO:0046113)	2.89646798
9	C4-dicarboxylate transport (GO:0015740)	2.87259650
10	positive regulation of mitochondrial fission (GO:0090141)	2.84732558
11	presynaptic membrane assembly (GO:0097105)	2.83238008
12	nonmotile primary cilium assembly (GO:0035058)	2.81586142
13	protein targeting to Golgi (GO:0000042)	2.81033023
14	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.79562601
15	nuclear pore organization (GO:0006999)	2.78007739
16	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.74895491
17	gamma-aminobutyric acid transport (GO:0015812)	2.73022499
18	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.70389106
19	negative regulation of DNA recombination (GO:0045910)	2.68933916
20	DNA double-strand break processing (GO:0000729)	2.63634026
21	forebrain neuron differentiation (GO:0021879)	2.62713133
22	neuron cell-cell adhesion (GO:0007158)	2.59172183
23	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.55877922
24	auditory behavior (GO:0031223)	2.55537428
25	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.54282489
26	regulation of synaptic vesicle exocytosis (GO:2000300)	2.54262099
27	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.54043318
28	negative regulation of neurotransmitter transport (GO:0051589)	2.53320611
29	postsynaptic membrane organization (GO:0001941)	2.52584801
30	protein neddylation (GO:0045116)	2.51854123
31	vocalization behavior (GO:0071625)	2.49073211
32	presynaptic membrane organization (GO:0097090)	2.47388675
33	epithelial cilium movement (GO:0003351)	2.46056217
34	regulation of sarcomere organization (GO:0060297)	2.44624749
35	ribonucleoprotein complex disassembly (GO:0032988)	2.42172304
36	regulation of cilium movement (GO:0003352)	2.41439893
37	synapse assembly (GO:0007416)	2.40750539
38	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.39815307
39	cilium assembly (GO:0042384)	2.36069831
40	mechanosensory behavior (GO:0007638)	2.35366574
41	cilium morphogenesis (GO:0060271)	2.34822471
42	cilium organization (GO:0044782)	2.33969852
43	protein localization to synapse (GO:0035418)	2.33493174
44	pore complex assembly (GO:0046931)	2.33169743
45	neuronal action potential propagation (GO:0019227)	2.31311727
46	negative regulation of heart rate (GO:0010459)	2.27575954
47	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.27312625
48	regulation of synaptic vesicle transport (GO:1902803)	2.26587497
49	regulation of cAMP-dependent protein kinase activity (GO:2000479)	2.25763914
50	axonal fasciculation (GO:0007413)	2.25591680
51	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.24642531
52	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.24642531
53	cerebellar Purkinje cell differentiation (GO:0021702)	2.23983747
54	protein polyglutamylation (GO:0018095)	2.23563469
55	microtubule-based transport (GO:0010970)	2.23201229
56	hippocampus development (GO:0021766)	2.21704780
57	negative regulation of protein localization to cell surface (GO:2000009)	2.21277843
58	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.20873508
59	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.20286310
60	synaptic vesicle endocytosis (GO:0048488)	2.19689224
61	regulation of clathrin-mediated endocytosis (GO:2000369)	2.18973712
62	cytoskeleton-dependent intracellular transport (GO:0030705)	2.18695767
63	neural tube formation (GO:0001841)	2.18605642
64	synaptic vesicle maturation (GO:0016188)	2.18379643
65	organelle disassembly (GO:1903008)	2.16958683
66	olfactory bulb development (GO:0021772)	2.16440911
67	organelle transport along microtubule (GO:0072384)	2.16414646
68	protein localization to Golgi apparatus (GO:0034067)	2.15445512
69	cilium movement (GO:0003341)	2.15260109
70	vascular smooth muscle contraction (GO:0014829)	2.15080534
71	protein localization to cilium (GO:0061512)	2.14777050
72	establishment of mitochondrion localization (GO:0051654)	2.14096713
73	appendage development (GO:0048736)	2.12686728
74	limb development (GO:0060173)	2.12686728
75	negative regulation of response to food (GO:0032096)	2.12436653
76	negative regulation of appetite (GO:0032099)	2.12436653
77	glutamate secretion (GO:0014047)	2.12369986
78	glycosphingolipid biosynthetic process (GO:0006688)	2.11146327
79	chromatin remodeling at centromere (GO:0031055)	2.10795260
80	acrosome assembly (GO:0001675)	2.10784780
81	negative regulation of neurotransmitter secretion (GO:0046929)	2.10416987
82	homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)	2.09753394
83	transmission of nerve impulse (GO:0019226)	2.09444706
84	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.09316428
85	DNA integration (GO:0015074)	2.08901339
86	kinetochore organization (GO:0051383)	2.08514625
87	intra-Golgi vesicle-mediated transport (GO:0006891)	2.07847499
88	synaptic vesicle exocytosis (GO:0016079)	2.06981133
89	neurotransmitter-gated ion channel clustering (GO:0072578)	2.06009375
90	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.05749883
91	centriole replication (GO:0007099)	2.05059998
92	regulation of oligodendrocyte differentiation (GO:0048713)	2.02865271
93	pyrimidine dimer repair (GO:0006290)	2.02768923
94	microtubule-based movement (GO:0007018)	2.02095728
95	CENP-A containing nucleosome assembly (GO:0034080)	2.02053360
96	regulation of cofactor metabolic process (GO:0051193)	2.00634647
97	regulation of coenzyme metabolic process (GO:0051196)	2.00634647
98	kinetochore assembly (GO:0051382)	2.00549459
99	photoreceptor cell maintenance (GO:0045494)	2.00280315
100	gastrulation with mouth forming second (GO:0001702)	1.99465309

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.59519301
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.57824053
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.19967424
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.16397312
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.07438536
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.78263915
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.50761934
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.50126834
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.45011153
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.43359549
11	FUS_26573619_Chip-Seq_HEK293_Human	2.28363162
12	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.18840161
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.18642374
14	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.13988446
15	EWS_26573619_Chip-Seq_HEK293_Human	2.11830748
16	P300_19829295_ChIP-Seq_ESCs_Human	2.08136496
17	SMAD4_21799915_ChIP-Seq_A2780_Human	1.98385035
18	ZNF274_21170338_ChIP-Seq_K562_Hela	1.98207226
19	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.97913189
20	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.97387319
21	VDR_22108803_ChIP-Seq_LS180_Human	1.89736701
22	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.80196859
23	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.78804773
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.78596378
25	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.74679734
26	STAT3_23295773_ChIP-Seq_U87_Human	1.71362433
27	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.71032157
28	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.69346552
29	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.64135805
30	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.57613743
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55998249
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.55899860
33	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.54700286
34	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.52844699
35	AR_21572438_ChIP-Seq_LNCaP_Human	1.51687554
36	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50286282
37	RNF2_27304074_Chip-Seq_NSC_Mouse	1.49619233
38	TCF4_23295773_ChIP-Seq_U87_Human	1.45580095
39	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.45017934
40	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.44170967
41	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.44017551
42	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.43051310
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.39521650
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39521650
45	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.39121993
46	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.38131445
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.37748355
48	AR_25329375_ChIP-Seq_VCAP_Human	1.36744468
49	ELK1_19687146_ChIP-ChIP_HELA_Human	1.35428719
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.35175880
51	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.33698852
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.32477436
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29497700
54	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.29450911
55	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.28482116
56	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.26481094
57	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.24945553
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23838842
59	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.23785458
60	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.22916554
61	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.22879515
62	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22162413
63	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.22162413
64	SOX9_26525672_Chip-Seq_HEART_Mouse	1.21083998
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19717356
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19459529
67	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.16890024
68	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.16309165
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.15822543
70	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.15322692
71	JUN_21703547_ChIP-Seq_K562_Human	1.15060072
72	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.14543778
73	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14405423
74	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.12124780
75	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.12119563
76	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10177220
77	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10172284
78	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.08585636
79	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.07445575
80	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07010805
81	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.01893712
82	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.99913784
83	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.99540232
84	BCAT_22108803_ChIP-Seq_LS180_Human	0.98879248
85	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98601525
86	MYC_18940864_ChIP-ChIP_HL60_Human	0.95861952
87	SOX2_19829295_ChIP-Seq_ESCs_Human	0.95189165
88	NANOG_19829295_ChIP-Seq_ESCs_Human	0.95189165
89	REST_21632747_ChIP-Seq_MESCs_Mouse	0.94974465
90	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94888709
91	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.94777322
92	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.94777322
93	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.94509213
94	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.94297516
95	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.93828479
96	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.93229808
97	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.93055213
98	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.92710002
99	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.92331237
100	TBL1_22424771_ChIP-Seq_293T_Human	0.92202584

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.28654494
2	MP0009046_muscle_twitch	2.22365102
3	MP0004859_abnormal_synaptic_plasticity	2.21679224
4	MP0001984_abnormal_olfaction	2.19107439
5	MP0004270_analgesia	2.15320473
6	MP0001529_abnormal_vocalization	2.13818208
7	MP0006276_abnormal_autonomic_nervous	2.09838984
8	MP0003787_abnormal_imprinting	2.00362837
9	MP0003890_abnormal_embryonic-extraembry	1.95338231
10	MP0000569_abnormal_digit_pigmentation	1.94833021
11	MP0008057_abnormal_DNA_replication	1.93886444
12	MP0002009_preneoplasia	1.90069131
13	MP0009697_abnormal_copulation	1.89726900
14	MP0001486_abnormal_startle_reflex	1.82466004
15	MP0000778_abnormal_nervous_system	1.70186549
16	MP0005394_taste/olfaction_phenotype	1.68641397
17	MP0005499_abnormal_olfactory_system	1.68641397
18	MP0008877_abnormal_DNA_methylation	1.67449246
19	MP0005423_abnormal_somatic_nervous	1.66315789
20	MP0003635_abnormal_synaptic_transmissio	1.61550355
21	MP0008789_abnormal_olfactory_epithelium	1.61176093
22	MP0002272_abnormal_nervous_system	1.60976572
23	MP0003122_maternal_imprinting	1.58334272
24	MP0005187_abnormal_penis_morphology	1.55956061
25	MP0005253_abnormal_eye_physiology	1.53284071
26	MP0003121_genomic_imprinting	1.50847000
27	MP0004147_increased_porphyrin_level	1.49436188
28	MP0006072_abnormal_retinal_apoptosis	1.42804597
29	MP0002063_abnormal_learning/memory/cond	1.42084224
30	MP0006292_abnormal_olfactory_placode	1.41488037
31	MP0002234_abnormal_pharynx_morphology	1.38788215
32	MP0002572_abnormal_emotion/affect_behav	1.37113151
33	MP0001293_anophthalmia	1.36643940
34	MP0002557_abnormal_social/conspecific_i	1.36556123
35	MP0000631_abnormal_neuroendocrine_gland	1.36286353
36	MP0002064_seizures	1.35062385
37	MP0009745_abnormal_behavioral_response	1.34772333
38	MP0000647_abnormal_sebaceous_gland	1.33235293
39	MP0004215_abnormal_myocardial_fiber	1.33230749
40	MP0005646_abnormal_pituitary_gland	1.33177999
41	MP0005551_abnormal_eye_electrophysiolog	1.32330270
42	MP0002638_abnormal_pupillary_reflex	1.31403154
43	MP0002734_abnormal_mechanical_nocicepti	1.28647050
44	MP0004133_heterotaxia	1.27446989
45	MP0005248_abnormal_Harderian_gland	1.25671321
46	MP0005645_abnormal_hypothalamus_physiol	1.24969273
47	MP0002736_abnormal_nociception_after	1.24472785
48	MP0003937_abnormal_limbs/digits/tail_de	1.23528550
49	MP0005386_behavior/neurological_phenoty	1.21781484
50	MP0004924_abnormal_behavior	1.21781484
51	MP0002233_abnormal_nose_morphology	1.19130846
52	MP0001968_abnormal_touch/_nociception	1.18270365
53	MP0001299_abnormal_eye_distance/	1.16297905
54	MP0001188_hyperpigmentation	1.15185702
55	MP0004142_abnormal_muscle_tone	1.09501188
56	MP0002102_abnormal_ear_morphology	1.09297618
57	MP0002067_abnormal_sensory_capabilities	1.08292729
58	MP0003718_maternal_effect	1.07817822
59	MP0000955_abnormal_spinal_cord	1.05391860
60	MP0004811_abnormal_neuron_physiology	1.03851810
61	MP0008058_abnormal_DNA_repair	1.03600043
62	MP0009780_abnormal_chondrocyte_physiolo	1.02356502
63	MP0008932_abnormal_embryonic_tissue	1.02162026
64	MP0002822_catalepsy	1.01302437
65	MP0002882_abnormal_neuron_morphology	1.00726702
66	MP0002653_abnormal_ependyma_morphology	1.00650852
67	MP0003137_abnormal_impulse_conducting	0.98394962
68	MP0008995_early_reproductive_senescence	0.97741779
69	MP0002735_abnormal_chemical_nociception	0.96732762
70	MP0001286_abnormal_eye_development	0.96494354
71	MP0002184_abnormal_innervation	0.95649701
72	MP0002152_abnormal_brain_morphology	0.94795453
73	MP0003861_abnormal_nervous_system	0.93117362
74	MP0002752_abnormal_somatic_nervous	0.92951044
75	MP0003136_yellow_coat_color	0.92437621
76	MP0010386_abnormal_urinary_bladder	0.91425044
77	MP0001485_abnormal_pinna_reflex	0.90444538
78	MP0005391_vision/eye_phenotype	0.90368478
79	MP0003119_abnormal_digestive_system	0.89629948
80	MP0000427_abnormal_hair_cycle	0.88132581
81	MP0003941_abnormal_skin_development	0.87901417
82	MP0004085_abnormal_heartbeat	0.87698812
83	MP0004043_abnormal_pH_regulation	0.87201419
84	MP0005167_abnormal_blood-brain_barrier	0.86784649
85	MP0010094_abnormal_chromosome_stability	0.84789423
86	MP0001177_atelectasis	0.84408638
87	MP0002090_abnormal_vision	0.83773528
88	MP0002733_abnormal_thermal_nociception	0.83147412
89	MP0003567_abnormal_fetal_cardiomyocyte	0.82058477
90	MP0003698_abnormal_male_reproductive	0.81569738
91	MP0001502_abnormal_circadian_rhythm	0.79701591
92	MP0003385_abnormal_body_wall	0.78371272
93	MP0001970_abnormal_pain_threshold	0.78205817
94	MP0000383_abnormal_hair_follicle	0.77475823
95	MP0010352_gastrointestinal_tract_polyps	0.75263260
96	MP0002160_abnormal_reproductive_system	0.74615220
97	MP0003011_delayed_dark_adaptation	0.74597831
98	MP0000026_abnormal_inner_ear	0.74558833
99	MP0003633_abnormal_nervous_system	0.74554762
100	MP0002697_abnormal_eye_size	0.73595886

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Gait imbalance (HP:0002141)	3.24246543
2	Papillary thyroid carcinoma (HP:0002895)	3.22505364
3	Congenital primary aphakia (HP:0007707)	3.11587005
4	Medial flaring of the eyebrow (HP:0010747)	3.09039211
5	Drooling (HP:0002307)	2.98655685
6	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.88985281
7	Hepatoblastoma (HP:0002884)	2.85590075
8	Nephrogenic diabetes insipidus (HP:0009806)	2.82299571
9	Genital tract atresia (HP:0001827)	2.79124054
10	Vaginal atresia (HP:0000148)	2.74424326
11	Poor coordination (HP:0002370)	2.71868752
12	Colon cancer (HP:0003003)	2.69827790
13	Excessive salivation (HP:0003781)	2.60229170
14	Febrile seizures (HP:0002373)	2.56374634
15	Cortical dysplasia (HP:0002539)	2.55816251
16	Short tibia (HP:0005736)	2.53133430
17	Pancreatic fibrosis (HP:0100732)	2.51062218
18	Thyroid-stimulating hormone excess (HP:0002925)	2.49497442
19	Tubulointerstitial nephritis (HP:0001970)	2.49032285
20	Chronic hepatic failure (HP:0100626)	2.44408163
21	Volvulus (HP:0002580)	2.39354177
22	Atonic seizures (HP:0010819)	2.37049267
23	True hermaphroditism (HP:0010459)	2.34589249
24	Hyperventilation (HP:0002883)	2.32681517
25	Pancreatic cysts (HP:0001737)	2.30705924
26	Progressive cerebellar ataxia (HP:0002073)	2.19925365
27	Urinary urgency (HP:0000012)	2.19604775
28	Broad-based gait (HP:0002136)	2.19367178
29	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.18978448
30	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.18978448
31	Medulloblastoma (HP:0002885)	2.14104708
32	Oligodactyly (hands) (HP:0001180)	2.12310272
33	Nephronophthisis (HP:0000090)	2.06672258
34	Genetic anticipation (HP:0003743)	2.04557123
35	Thyroid carcinoma (HP:0002890)	2.03732341
36	Abnormality of midbrain morphology (HP:0002418)	2.02648908
37	Molar tooth sign on MRI (HP:0002419)	2.02648908
38	Hyperglycinemia (HP:0002154)	2.01998476
39	Myokymia (HP:0002411)	2.01895531
40	Postaxial foot polydactyly (HP:0001830)	2.00705537
41	Impaired vibration sensation in the lower limbs (HP:0002166)	2.00500263
42	Abnormality of the corticospinal tract (HP:0002492)	1.99969043
43	Polyphagia (HP:0002591)	1.98443182
44	Hypsarrhythmia (HP:0002521)	1.98368275
45	Specific learning disability (HP:0001328)	1.98247604
46	Astrocytoma (HP:0009592)	1.97896048
47	Abnormality of the astrocytes (HP:0100707)	1.97896048
48	Bifid tongue (HP:0010297)	1.97596244
49	Broad foot (HP:0001769)	1.96741095
50	Epileptiform EEG discharges (HP:0011182)	1.96139731
51	EEG with generalized epileptiform discharges (HP:0011198)	1.93740394
52	Gaze-evoked nystagmus (HP:0000640)	1.91501625
53	Abnormality of the renal medulla (HP:0100957)	1.90352342
54	Renal cortical cysts (HP:0000803)	1.87371457
55	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.86812292
56	Urinary bladder sphincter dysfunction (HP:0002839)	1.86721445
57	Postaxial hand polydactyly (HP:0001162)	1.86352477
58	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.84802170
59	Abnormality of the labia minora (HP:0012880)	1.79835459
60	Absent eyebrow (HP:0002223)	1.79594029
61	Abnormality of the renal cortex (HP:0011035)	1.75332873
62	Dyskinesia (HP:0100660)	1.74583614
63	Focal seizures (HP:0007359)	1.71526305
64	Termporal pattern (HP:0011008)	1.71485474
65	Insidious onset (HP:0003587)	1.71485474
66	Glioma (HP:0009733)	1.70541183
67	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.70259866
68	Abnormality of alanine metabolism (HP:0010916)	1.70259866
69	Hyperalaninemia (HP:0003348)	1.70259866
70	Acanthocytosis (HP:0001927)	1.69694675
71	Abnormality of secondary sexual hair (HP:0009888)	1.69664141
72	Abnormality of the axillary hair (HP:0100134)	1.69664141
73	Spastic gait (HP:0002064)	1.69045021
74	Micropenis (HP:0000054)	1.67516412
75	Labial hypoplasia (HP:0000066)	1.67410787
76	Rhabdomyosarcoma (HP:0002859)	1.67313177
77	Decreased testicular size (HP:0008734)	1.66669446
78	Median cleft lip (HP:0000161)	1.65937932
79	Abnormal auditory evoked potentials (HP:0006958)	1.65349138
80	Fair hair (HP:0002286)	1.64775152
81	Absent speech (HP:0001344)	1.63207619
82	Epileptic encephalopathy (HP:0200134)	1.60894460
83	Truncal obesity (HP:0001956)	1.60414942
84	Absent hair (HP:0002298)	1.58682365
85	Dialeptic seizures (HP:0011146)	1.57418399
86	Decreased lacrimation (HP:0000633)	1.57376219
87	Spastic tetraplegia (HP:0002510)	1.57317261
88	Prominent nasal bridge (HP:0000426)	1.57249180
89	Split foot (HP:0001839)	1.55922383
90	Focal motor seizures (HP:0011153)	1.55815363
91	Aplasia/Hypoplasia of the lens (HP:0008063)	1.55655426
92	Occipital encephalocele (HP:0002085)	1.55631941
93	Abnormality of chromosome stability (HP:0003220)	1.55458619
94	Impulsivity (HP:0100710)	1.55433906
95	Cutaneous finger syndactyly (HP:0010554)	1.54624535
96	Renal hypoplasia (HP:0000089)	1.54378364
97	Astigmatism (HP:0000483)	1.54371538
98	Supernumerary spleens (HP:0009799)	1.52004531
99	Abnormal social behavior (HP:0012433)	1.51586481
100	Impaired social interactions (HP:0000735)	1.51586481

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K4	3.53778684
2	MAP2K7	2.86116901
3	CASK	2.63108038
4	BCR	2.53854231
5	EPHA4	2.27584190
6	FRK	2.25790017
7	WNK3	2.20329028
8	MAP4K2	2.12307804
9	ZAK	2.02949508
10	AKT3	2.02518622
11	SRPK1	1.92895309
12	CSNK1A1L	1.91782500
13	EPHA3	1.87730772
14	MARK1	1.86952201
15	MAPK13	1.72278665
16	ERBB3	1.72273001
17	CSNK1G2	1.67840709
18	CSNK1G1	1.67762954
19	TRIM28	1.66977752
20	CSNK1G3	1.65875576
21	PINK1	1.64100702
22	BMPR1B	1.56734251
23	BRD4	1.44635221
24	PLK2	1.38255701
25	STK39	1.34139055
26	CAMKK2	1.31579953
27	CAMK1G	1.25250579
28	BRSK2	1.23973396
29	FER	1.21211367
30	MST4	1.20642752
31	CDC7	1.20036994
32	PLK4	1.19685999
33	CDK19	1.18778960
34	NEK1	1.15804798
35	SGK2	1.15442594
36	NTRK3	1.12374189
37	CAMK1D	1.07863799
38	PAK3	1.07685408
39	SGK494	1.06016026
40	SGK223	1.06016026
41	NTRK2	1.02486284
42	DYRK3	1.01872473
43	MAP2K4	0.98734193
44	NUAK1	0.95507868
45	MINK1	0.92937258
46	CAMK4	0.90014223
47	OXSR1	0.87022313
48	TNIK	0.86553965
49	TLK1	0.83150869
50	PRKCE	0.77774698
51	ACVR1B	0.77319639
52	PBK	0.75156958
53	NLK	0.75086033
54	MAP3K6	0.72628864
55	UHMK1	0.72513568
56	RPS6KA5	0.72195578
57	DYRK2	0.71952331
58	CAMK1	0.71797372
59	STK38L	0.71710348
60	PAK6	0.71422548
61	PLK1	0.70589017
62	PKN1	0.69445634
63	PRKCG	0.66582498
64	PIK3CA	0.65721995
65	DYRK1A	0.65194425
66	VRK1	0.64763159
67	GRK1	0.64045505
68	CAMK2A	0.63694982
69	LATS1	0.61164384
70	PRKAA1	0.61101397
71	CDK5	0.59134743
72	INSRR	0.59014901
73	ATR	0.55995864
74	WNK4	0.55197140
75	BRSK1	0.53703728
76	ERBB2	0.53510812
77	ATM	0.53428871
78	DYRK1B	0.53120710
79	AURKB	0.51797231
80	CDK14	0.51643818
81	PRKD3	0.51281606
82	BCKDK	0.50954655
83	CCNB1	0.49915332
84	SGK3	0.49511419
85	PLK3	0.47390881
86	MKNK2	0.47306239
87	CDK3	0.46271418
88	CHEK2	0.45884246
89	RPS6KA4	0.45781439
90	CSNK1E	0.44969270
91	TTK	0.44957038
92	CDK18	0.43522423
93	PRKACB	0.42991031
94	MAP3K5	0.42706044
95	OBSCN	0.42378567
96	CSNK1D	0.42126275
97	SGK1	0.41620592
98	TEC	0.40237190
99	CDK15	0.39312500
100	PRKAA2	0.39234901

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.87566999
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.45908197
3	Alcoholism_Homo sapiens_hsa05034	2.29212049
4	Steroid biosynthesis_Homo sapiens_hsa00100	2.28686612
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.04623199
6	GABAergic synapse_Homo sapiens_hsa04727	1.85953383
7	Propanoate metabolism_Homo sapiens_hsa00640	1.77716243
8	Fanconi anemia pathway_Homo sapiens_hsa03460	1.64704996
9	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.64158552
10	Circadian rhythm_Homo sapiens_hsa04710	1.63981949
11	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.55967916
12	Morphine addiction_Homo sapiens_hsa05032	1.51891755
13	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.49143509
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.41371620
15	Protein export_Homo sapiens_hsa03060	1.38759655
16	Butanoate metabolism_Homo sapiens_hsa00650	1.38735967
17	Glutamatergic synapse_Homo sapiens_hsa04724	1.32054977
18	Taste transduction_Homo sapiens_hsa04742	1.30586462
19	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.29903307
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.29855186
21	Mismatch repair_Homo sapiens_hsa03430	1.29125865
22	Circadian entrainment_Homo sapiens_hsa04713	1.27923190
23	Dopaminergic synapse_Homo sapiens_hsa04728	1.27204296
24	Basal transcription factors_Homo sapiens_hsa03022	1.27078844
25	Non-homologous end-joining_Homo sapiens_hsa03450	1.26346195
26	Olfactory transduction_Homo sapiens_hsa04740	1.19083716
27	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.18131215
28	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.16091704
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.13549386
30	Oocyte meiosis_Homo sapiens_hsa04114	1.10479288
31	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.08930204
32	Homologous recombination_Homo sapiens_hsa03440	1.07885383
33	Serotonergic synapse_Homo sapiens_hsa04726	1.04295372
34	Fatty acid elongation_Homo sapiens_hsa00062	1.02824892
35	Fatty acid metabolism_Homo sapiens_hsa01212	0.99798556
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.97649307
37	Oxidative phosphorylation_Homo sapiens_hsa00190	0.96391824
38	beta-Alanine metabolism_Homo sapiens_hsa00410	0.94329166
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.93645292
40	Huntingtons disease_Homo sapiens_hsa05016	0.93016290
41	Cell cycle_Homo sapiens_hsa04110	0.91092134
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.89614650
43	Cardiac muscle contraction_Homo sapiens_hsa04260	0.89282744
44	Phototransduction_Homo sapiens_hsa04744	0.88720055
45	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.88662493
46	Amphetamine addiction_Homo sapiens_hsa05031	0.86373606
47	Arginine and proline metabolism_Homo sapiens_hsa00330	0.85883846
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85337835
49	Peroxisome_Homo sapiens_hsa04146	0.85312374
50	Nitrogen metabolism_Homo sapiens_hsa00910	0.85263215
51	Parkinsons disease_Homo sapiens_hsa05012	0.85145633
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.83512699
53	Insulin secretion_Homo sapiens_hsa04911	0.83284347
54	Regulation of autophagy_Homo sapiens_hsa04140	0.82432713
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.82203115
56	RNA degradation_Homo sapiens_hsa03018	0.81175763
57	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.78294581
58	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.77241088
59	Cocaine addiction_Homo sapiens_hsa05030	0.76676890
60	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.75882953
61	Lysine degradation_Homo sapiens_hsa00310	0.74534663
62	Gap junction_Homo sapiens_hsa04540	0.74215297
63	RNA polymerase_Homo sapiens_hsa03020	0.73212870
64	Long-term depression_Homo sapiens_hsa04730	0.73106281
65	Hippo signaling pathway_Homo sapiens_hsa04390	0.73059587
66	Linoleic acid metabolism_Homo sapiens_hsa00591	0.72595644
67	Axon guidance_Homo sapiens_hsa04360	0.69001285
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.68361329
69	Pyruvate metabolism_Homo sapiens_hsa00620	0.67717938
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.67594885
71	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.64798321
72	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.62710863
73	Alzheimers disease_Homo sapiens_hsa05010	0.62110759
74	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.62031937
75	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.61823879
76	Salivary secretion_Homo sapiens_hsa04970	0.61366912
77	Adherens junction_Homo sapiens_hsa04520	0.60541056
78	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.59881083
79	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.59831940
80	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59723190
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57383612
82	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.57298617
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57147136
84	Collecting duct acid secretion_Homo sapiens_hsa04966	0.56971883
85	Cholinergic synapse_Homo sapiens_hsa04725	0.56734844
86	RNA transport_Homo sapiens_hsa03013	0.55107274
87	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.54485355
88	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.53585636
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.53400471
90	Basal cell carcinoma_Homo sapiens_hsa05217	0.53108361
91	Wnt signaling pathway_Homo sapiens_hsa04310	0.51150646
92	Tight junction_Homo sapiens_hsa04530	0.50304877
93	Arginine biosynthesis_Homo sapiens_hsa00220	0.49790162
94	mRNA surveillance pathway_Homo sapiens_hsa03015	0.49199772
95	Nucleotide excision repair_Homo sapiens_hsa03420	0.49071456
96	Tryptophan metabolism_Homo sapiens_hsa00380	0.47765653
97	Caffeine metabolism_Homo sapiens_hsa00232	0.46607221
98	cAMP signaling pathway_Homo sapiens_hsa04024	0.46594137
99	Fatty acid degradation_Homo sapiens_hsa00071	0.45411827
100	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.45376376

MTRNR2L12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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