ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	muscle atrophy (GO:0014889)	9.15122221
2	skeletal muscle tissue regeneration (GO:0043403)	8.79489853
3	negative regulation of muscle hypertrophy (GO:0014741)	8.47262621
4	actin-myosin filament sliding (GO:0033275)	7.93281867
5	muscle filament sliding (GO:0030049)	7.93281867
6	regulation of skeletal muscle contraction (GO:0014819)	7.49845036
7	response to muscle activity (GO:0014850)	6.59715016
8	actin-mediated cell contraction (GO:0070252)	6.56276212
9	negative regulation of skeletal muscle tissue development (GO:0048642)	6.46147685
10	cellular response to dexamethasone stimulus (GO:0071549)	5.46656312
11	protein K6-linked ubiquitination (GO:0085020)	5.24084098
12	response to activity (GO:0014823)	5.15458953
13	response to dexamethasone (GO:0071548)	5.02852915
14	striated muscle adaptation (GO:0014888)	4.78824609
15	actin filament-based movement (GO:0030048)	4.52059373
16	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	4.31585707
17	protein polyglutamylation (GO:0018095)	4.28670377
18	regulation of muscle hypertrophy (GO:0014743)	4.15303667
19	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.03825096
20	heparin metabolic process (GO:0030202)	4.00051659
21	heparin biosynthetic process (GO:0030210)	4.00051659
22	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.99762935
23	muscle adaptation (GO:0043500)	3.77899367
24	skeletal muscle contraction (GO:0003009)	3.69626835
25	protein neddylation (GO:0045116)	3.64443695
26	regulation of female receptivity (GO:0045924)	3.53992232
27	tissue regeneration (GO:0042246)	3.41211413
28	protein trimerization (GO:0070206)	3.37310974
29	behavioral response to nicotine (GO:0035095)	3.34093502
30	regulation of relaxation of muscle (GO:1901077)	3.31039720
31	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	3.27921354
32	response to electrical stimulus (GO:0051602)	3.26272119
33	myotube cell development (GO:0014904)	3.24977441
34	regulation of centriole replication (GO:0046599)	3.22559291
35	response to testosterone (GO:0033574)	3.11743131
36	lymphangiogenesis (GO:0001946)	3.08591430
37	muscle organ development (GO:0007517)	3.07224946
38	muscle structure development (GO:0061061)	3.05025004
39	calcium ion import (GO:0070509)	2.97025763
40	DNA damage response, signal transduction resulting in transcription (GO:0042772)	2.93957493
41	regulation of sarcomere organization (GO:0060297)	2.93921959
42	negative regulation of muscle tissue development (GO:1901862)	2.89947095
43	cellular response to glucocorticoid stimulus (GO:0071385)	2.89889838
44	regulation of meiosis I (GO:0060631)	2.89859556
45	negative regulation of striated muscle tissue development (GO:0045843)	2.88501485
46	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.85586953
47	regulation of DNA methylation (GO:0044030)	2.85395361
48	platelet dense granule organization (GO:0060155)	2.84891643
49	axoneme assembly (GO:0035082)	2.83775453
50	female mating behavior (GO:0060180)	2.82613876
51	positive regulation of protein homodimerization activity (GO:0090073)	2.77017348
52	negative regulation of muscle organ development (GO:0048635)	2.76062614
53	muscle system process (GO:0003012)	2.71478483
54	neuronal action potential (GO:0019228)	2.71148472
55	cellular response to corticosteroid stimulus (GO:0071384)	2.66314473
56	cellular ketone body metabolic process (GO:0046950)	2.65063609
57	kynurenine metabolic process (GO:0070189)	2.63219662
58	positive regulation of endothelial cell differentiation (GO:0045603)	2.62304136
59	regulation of germinal center formation (GO:0002634)	2.61872297
60	fat-soluble vitamin catabolic process (GO:0042363)	2.60741839
61	vitamin catabolic process (GO:0009111)	2.60741839
62	detection of light stimulus involved in sensory perception (GO:0050962)	2.60541735
63	detection of light stimulus involved in visual perception (GO:0050908)	2.60541735
64	regulation of histone H3-K9 methylation (GO:0051570)	2.60271538
65	neuronal action potential propagation (GO:0019227)	2.59911447
66	positive regulation of histone H3-K4 methylation (GO:0051571)	2.59369753
67	negative regulation of organelle assembly (GO:1902116)	2.58649828
68	mitochondrial calcium ion homeostasis (GO:0051560)	2.58553784
69	response to inactivity (GO:0014854)	2.58248666
70	dosage compensation (GO:0007549)	2.57669823
71	regulation of gene expression by genetic imprinting (GO:0006349)	2.57445548
72	muscle contraction (GO:0006936)	2.55043549
73	regulation of endothelial cell differentiation (GO:0045601)	2.53345085
74	positive regulation of vasculogenesis (GO:2001214)	2.52134267
75	positive regulation of cAMP-mediated signaling (GO:0043950)	2.50144357
76	positive regulation of meiosis (GO:0045836)	2.48120048
77	cytidine metabolic process (GO:0046087)	2.44452701
78	cytidine catabolic process (GO:0006216)	2.44452701
79	cytidine deamination (GO:0009972)	2.44452701
80	appendage development (GO:0048736)	2.43811622
81	limb development (GO:0060173)	2.43811622
82	cAMP catabolic process (GO:0006198)	2.41594915
83	skeletal muscle fiber development (GO:0048741)	2.39519763
84	DNA deamination (GO:0045006)	2.38973997
85	tryptophan catabolic process (GO:0006569)	2.38781877
86	indole-containing compound catabolic process (GO:0042436)	2.38781877
87	indolalkylamine catabolic process (GO:0046218)	2.38781877
88	nephron tubule morphogenesis (GO:0072078)	2.37518202
89	nephron epithelium morphogenesis (GO:0072088)	2.37518202
90	sperm motility (GO:0030317)	2.36697657
91	regulation of striated muscle contraction (GO:0006942)	2.36075579
92	cellular response to ketone (GO:1901655)	2.35596493
93	negative regulation of histone methylation (GO:0031061)	2.34493170
94	negative regulation of fatty acid biosynthetic process (GO:0045717)	2.33618764
95	motile cilium assembly (GO:0044458)	2.30926703
96	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.30811565
97	indolalkylamine metabolic process (GO:0006586)	2.30132874
98	response to gravity (GO:0009629)	12.1793023
99	skeletal muscle adaptation (GO:0043501)	10.3245023
100	striated muscle atrophy (GO:0014891)	10.2002249

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	5.43965250
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.70517656
3	TAF15_26573619_Chip-Seq_HEK293_Human	3.63616039
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.97845994
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.75681104
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.68696963
7	FUS_26573619_Chip-Seq_HEK293_Human	2.64214592
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.58665924
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.57559554
10	AR_21572438_ChIP-Seq_LNCaP_Human	2.46004894
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.37457175
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.27231701
13	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.25538093
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.22881824
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.14259066
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.11091309
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.10661430
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.88866715
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.88483483
20	SMAD4_21799915_ChIP-Seq_A2780_Human	1.87404453
21	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.86813944
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.84909980
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.84738346
24	P300_19829295_ChIP-Seq_ESCs_Human	1.81692034
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79016756
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78439751
27	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.73129095
28	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.72959158
29	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.70226635
30	EWS_26573619_Chip-Seq_HEK293_Human	1.59697416
31	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.58662324
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.58537147
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.55277514
34	STAT3_23295773_ChIP-Seq_U87_Human	1.54618254
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.54302299
36	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.45135255
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.43339075
38	TCF4_23295773_ChIP-Seq_U87_Human	1.43158917
39	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.42701541
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.41779243
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41779243
42	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.40998459
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.40884136
44	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.38619130
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.35518366
46	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.34620408
47	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.33908477
48	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.33208021
49	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.32614166
50	BCAT_22108803_ChIP-Seq_LS180_Human	1.31012717
51	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27709433
52	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.27249743
53	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26900081
54	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.26624976
55	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26081371
56	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.25707559
57	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.24402510
58	AR_25329375_ChIP-Seq_VCAP_Human	1.22845767
59	KDM2B_26808549_Chip-Seq_REH_Human	1.21491144
60	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.21197750
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21157034
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21157034
63	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20105144
64	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.19818851
65	P53_22387025_ChIP-Seq_ESCs_Mouse	1.18884544
66	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.17764550
67	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.17062461
68	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.16949500
69	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.16138103
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16138103
71	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.14284374
72	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.12674821
73	RNF2_27304074_Chip-Seq_NSC_Mouse	1.11569837
74	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.10650715
75	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10282280
76	CDX2_22108803_ChIP-Seq_LS180_Human	1.09382202
77	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.08528901
78	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.08298237
79	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.08290640
80	TCF4_22108803_ChIP-Seq_LS180_Human	1.07381767
81	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06309658
82	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05749133
83	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05355463
84	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.04506001
85	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.04290813
86	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.02231428
87	AR_20517297_ChIP-Seq_VCAP_Human	1.02038386
88	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.01179295
89	RUNX2_22187159_ChIP-Seq_PCA_Human	1.00976342
90	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.00493460
91	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.00464561
92	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.00255599
93	IRF1_19129219_ChIP-ChIP_H3396_Human	0.99533800
94	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.99336899
95	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98644061
96	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.98098663
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97262062
98	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.96870514
99	RXR_22108803_ChIP-Seq_LS180_Human	0.96515321
100	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.94525160

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004145_abnormal_muscle_electrophysio	5.13762509
2	MP0004036_abnormal_muscle_relaxation	4.06590738
3	MP0000747_muscle_weakness	4.02580587
4	MP0002736_abnormal_nociception_after	3.08624196
5	MP0005083_abnormal_biliary_tract	3.08465667
6	MP0003646_muscle_fatigue	3.07623387
7	MP0001968_abnormal_touch/_nociception	2.77221846
8	MP0002089_abnormal_postnatal_growth/wei	2.64814635
9	MP0005167_abnormal_blood-brain_barrier	2.57837683
10	MP0002269_muscular_atrophy	2.54975176
11	MP0001879_abnormal_lymphatic_vessel	2.45563463
12	MP0005620_abnormal_muscle_contractility	2.37597959
13	MP0000749_muscle_degeneration	2.37572273
14	MP0002106_abnormal_muscle_physiology	2.26692562
15	MP0002108_abnormal_muscle_morphology	2.21976665
16	MP0000759_abnormal_skeletal_muscle	2.20129260
17	MP0004084_abnormal_cardiac_muscle	2.12315129
18	MP0002837_dystrophic_cardiac_calcinosis	1.94984234
19	MP0000372_irregular_coat_pigmentation	1.93059219
20	MP0005646_abnormal_pituitary_gland	1.87450658
21	MP0004885_abnormal_endolymph	1.83103701
22	MP0005369_muscle_phenotype	1.76460807
23	MP0004087_abnormal_muscle_fiber	1.72922641
24	MP0004270_analgesia	1.69220486
25	MP0010368_abnormal_lymphatic_system	1.64726319
26	MP0004484_altered_response_of	1.62173031
27	MP0002102_abnormal_ear_morphology	1.59632204
28	MP0000427_abnormal_hair_cycle	1.59141429
29	MP0006276_abnormal_autonomic_nervous	1.55601908
30	MP0005645_abnormal_hypothalamus_physiol	1.55357479
31	MP0009780_abnormal_chondrocyte_physiolo	1.54039645
32	MP0009697_abnormal_copulation	1.53441110
33	MP0004130_abnormal_muscle_cell	1.53394170
34	MP0002638_abnormal_pupillary_reflex	1.51473371
35	MP0004215_abnormal_myocardial_fiber	1.51175970
36	MP0008877_abnormal_DNA_methylation	1.48467122
37	MP0008872_abnormal_physiological_respon	1.44608222
38	MP0004142_abnormal_muscle_tone	1.43726325
39	MP0004147_increased_porphyrin_level	1.41979467
40	MP0003959_abnormal_lean_body	1.41238680
41	MP0003787_abnormal_imprinting	1.39307350
42	MP0004043_abnormal_pH_regulation	1.36596786
43	MP0002138_abnormal_hepatobiliary_system	1.30555195
44	MP0005551_abnormal_eye_electrophysiolog	1.29251562
45	MP0003880_abnormal_central_pattern	1.26268178
46	MP0000230_abnormal_systemic_arterial	1.25510018
47	MP0000631_abnormal_neuroendocrine_gland	1.19503414
48	MP0006072_abnormal_retinal_apoptosis	1.16771770
49	MP0000013_abnormal_adipose_tissue	1.15263703
50	MP0002876_abnormal_thyroid_physiology	1.14976690
51	MP0000566_synostosis	1.13680211
52	MP0000049_abnormal_middle_ear	1.13055541
53	MP0009745_abnormal_behavioral_response	1.12955589
54	MP0004134_abnormal_chest_morphology	1.11659465
55	MP0000467_abnormal_esophagus_morphology	1.03926648
56	MP0002272_abnormal_nervous_system	1.03658696
57	MP0003045_fibrosis	1.02275591
58	MP0000465_gastrointestinal_hemorrhage	0.98194576
59	MP0008775_abnormal_heart_ventricle	0.98009365
60	MP0001486_abnormal_startle_reflex	0.97305775
61	MP0003119_abnormal_digestive_system	0.95696013
62	MP0002733_abnormal_thermal_nociception	0.95382723
63	MP0002095_abnormal_skin_pigmentation	0.94731406
64	MP0002734_abnormal_mechanical_nocicepti	0.93355600
65	MP0004085_abnormal_heartbeat	0.91746343
66	MP0002735_abnormal_chemical_nociception	0.91531380
67	MP0005084_abnormal_gallbladder_morpholo	0.91211229
68	MP0003724_increased_susceptibility_to	0.91079780
69	MP0003937_abnormal_limbs/digits/tail_de	0.90778492
70	MP0005253_abnormal_eye_physiology	0.89746644
71	MP0003938_abnormal_ear_development	0.89149687
72	MP0008875_abnormal_xenobiotic_pharmacok	0.87615872
73	MP0000569_abnormal_digit_pigmentation	0.84465871
74	MP0002653_abnormal_ependyma_morphology	0.83927789
75	MP0002127_abnormal_cardiovascular_syste	0.83834980
76	MP0000733_abnormal_muscle_development	0.82940228
77	MP0002896_abnormal_bone_mineralization	0.82469173
78	MP0002277_abnormal_respiratory_mucosa	0.82266755
79	MP0005464_abnormal_platelet_physiology	0.80600344
80	MP0003950_abnormal_plasma_membrane	0.80265911
81	MP0001661_extended_life_span	0.80006466
82	MP0000751_myopathy	0.79396283
83	MP0002067_abnormal_sensory_capabilities	0.79174840
84	MP0003638_abnormal_response/metabolism_	0.76751180
85	MP0005410_abnormal_fertilization	0.76685980
86	MP0001970_abnormal_pain_threshold	0.76264769
87	MP0001501_abnormal_sleep_pattern	0.74580270
88	MP0002115_abnormal_skeleton_extremities	0.73648267
89	MP0005647_abnormal_sex_gland	0.71385217
90	MP0001485_abnormal_pinna_reflex	0.70083423
91	MP0009250_abnormal_appendicular_skeleto	0.69173720
92	MP0002109_abnormal_limb_morphology	0.67366707
93	MP0009046_muscle_twitch	0.66810139
94	MP0005085_abnormal_gallbladder_physiolo	0.66751018
95	MP0001963_abnormal_hearing_physiology	0.64475010
96	MP0003705_abnormal_hypodermis_morpholog	0.64237445
97	MP0001765_abnormal_ion_homeostasis	0.63835154
98	MP0003195_calcinosis	0.62907460
99	MP0003137_abnormal_impulse_conducting	0.62764509
100	MP0005334_abnormal_fat_pad	0.62026891

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Palpebral edema (HP:0100540)	7.59053876
2	Distal arthrogryposis (HP:0005684)	6.12907266
3	Nemaline bodies (HP:0003798)	5.90666103
4	Absent phalangeal crease (HP:0006109)	5.52608010
5	Round ear (HP:0100830)	5.41236193
6	Exercise-induced myalgia (HP:0003738)	5.19469680
7	Ulnar deviation of the wrist (HP:0003049)	5.11600914
8	Mask-like facies (HP:0000298)	5.01451563
9	Abnormal finger flexion creases (HP:0006143)	4.92793869
10	Hyperkalemia (HP:0002153)	4.91869464
11	Muscle fiber inclusion bodies (HP:0100299)	4.70198173
12	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	4.64144854
13	Calcaneovalgus deformity (HP:0001848)	3.96692529
14	Periorbital edema (HP:0100539)	3.80971843
15	Deformed tarsal bones (HP:0008119)	3.74775928
16	Facial edema (HP:0000282)	3.64493725
17	Exercise-induced muscle cramps (HP:0003710)	3.32804189
18	Abnormality of potassium homeostasis (HP:0011042)	3.21611299
19	Decreased circulating renin level (HP:0003351)	3.09507268
20	Type 1 muscle fiber predominance (HP:0003803)	3.02756033
21	3-Methylglutaconic aciduria (HP:0003535)	2.97948731
22	Myoglobinuria (HP:0002913)	2.89703665
23	Decreased central vision (HP:0007663)	2.87009843
24	Myotonia (HP:0002486)	2.74356866
25	Fibular aplasia (HP:0002990)	2.70028657
26	Congenital stationary night blindness (HP:0007642)	2.60149396
27	Neoplasm of the heart (HP:0100544)	2.54558309
28	Nonprogressive disorder (HP:0003680)	2.50501894
29	Hypoplasia of the fovea (HP:0007750)	2.44427387
30	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.44427387
31	Myopathic facies (HP:0002058)	2.43688449
32	Hypokalemia (HP:0002900)	2.26478269
33	Abnormality of the fovea (HP:0000493)	2.26308229
34	Abnormality of the renal cortex (HP:0011035)	2.22758202
35	Nephronophthisis (HP:0000090)	2.19873878
36	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.19825114
37	Absent/shortened dynein arms (HP:0200106)	2.19825114
38	Polydipsia (HP:0001959)	2.13661601
39	Abnormal drinking behavior (HP:0030082)	2.13661601
40	Molar tooth sign on MRI (HP:0002419)	2.12632261
41	Abnormality of midbrain morphology (HP:0002418)	2.12632261
42	Abolished electroretinogram (ERG) (HP:0000550)	2.11511023
43	Abnormality of chloride homeostasis (HP:0011422)	2.06967087
44	Pancreatic cysts (HP:0001737)	2.05965276
45	Abnormality of the renal medulla (HP:0100957)	2.03290241
46	Pancreatic fibrosis (HP:0100732)	2.02879763
47	Prolonged bleeding time (HP:0003010)	2.02651354
48	Broad-based gait (HP:0002136)	2.02119922
49	Attenuation of retinal blood vessels (HP:0007843)	2.00028044
50	Hypoplastic iliac wings (HP:0002866)	1.95301993
51	Abnormality of macular pigmentation (HP:0008002)	1.94723617
52	True hermaphroditism (HP:0010459)	1.94399434
53	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.94192037
54	Increased corneal curvature (HP:0100692)	1.89132424
55	Keratoconus (HP:0000563)	1.89132424
56	Hypoplastic ischia (HP:0003175)	1.83351157
57	Thyroid-stimulating hormone excess (HP:0002925)	1.81086624
58	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.80148659
59	Febrile seizures (HP:0002373)	1.79730475
60	Muscle hypertrophy of the lower extremities (HP:0008968)	1.79476498
61	Lip pit (HP:0100267)	1.76732561
62	Abnormal rod and cone electroretinograms (HP:0008323)	1.76041167
63	Concave nail (HP:0001598)	1.75216367
64	Abnormality of the ischium (HP:0003174)	1.70800667
65	Absent speech (HP:0001344)	1.70351374
66	Malignant hyperthermia (HP:0002047)	1.69422021
67	Down-sloping shoulders (HP:0200021)	1.68183014
68	Short tibia (HP:0005736)	1.68179946
69	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.68095294
70	Pachygyria (HP:0001302)	1.67634471
71	Abnormality of the nasal septum (HP:0000419)	1.66945697
72	Bulbous nose (HP:0000414)	1.66429637
73	Renal cortical cysts (HP:0000803)	1.65888630
74	Polyuria (HP:0000103)	1.65737500
75	Difficulty running (HP:0009046)	1.64985538
76	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.64697465
77	2-3 toe syndactyly (HP:0004691)	1.63554819
78	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.63406280
79	Hypoplasia of the uterus (HP:0000013)	1.63081917
80	Adactyly (HP:0009776)	1.62297962
81	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.61484828
82	Morphological abnormality of the middle ear (HP:0008609)	1.60793812
83	Constricted visual fields (HP:0001133)	1.60449409
84	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.59079524
85	Metatarsus adductus (HP:0001840)	1.58892503
86	Aplasia/hypoplasia of the uterus (HP:0008684)	1.58419551
87	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.58270848
88	Short 4th metacarpal (HP:0010044)	1.58270848
89	Atrioventricular block (HP:0001678)	1.57129723
90	Bony spicule pigmentary retinopathy (HP:0007737)	1.57102134
91	Rhabdomyolysis (HP:0003201)	1.56022279
92	Lissencephaly (HP:0001339)	1.55672093
93	Short phalanx of the thumb (HP:0009660)	1.55561273
94	Delayed CNS myelination (HP:0002188)	1.55501381
95	Abnormality of renin-angiotensin system (HP:0000847)	1.55249984
96	Menorrhagia (HP:0000132)	1.54880158
97	Oligomenorrhea (HP:0000876)	1.54837308
98	Petechiae (HP:0000967)	1.54688011
99	Abnormality of the columella (HP:0009929)	1.53993774
100	Abnormality of the calcaneus (HP:0008364)	1.53752224

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	5.66491454
2	PHKG2	3.32217663
3	PHKG1	3.32217663
4	OBSCN	3.19876403
5	WNK4	2.66381164
6	TAOK3	2.59370305
7	FRK	2.30515871
8	MAP4K2	2.23002330
9	MAPK13	2.20342038
10	TLK1	2.14767722
11	PINK1	2.10245020
12	NUAK1	2.10113589
13	PIK3CA	2.03092632
14	CASK	1.97512256
15	MST4	1.76624744
16	ADRBK2	1.73600242
17	CAMKK2	1.71617482
18	ZAK	1.58787755
19	TEC	1.58462521
20	PIK3CG	1.53627768
21	MAP3K4	1.47869699
22	CAMK1D	1.46883173
23	WNK1	1.41598725
24	STK39	1.34363522
25	GRK1	1.30080049
26	CAMK1G	1.29665912
27	TXK	1.24917220
28	TNIK	1.24741593
29	CSNK1G1	1.24645167
30	IRAK1	1.23962513
31	WNK3	1.20565989
32	JAK3	1.14401163
33	CSNK1A1L	1.06145414
34	DAPK2	1.03352156
35	BCR	0.98968534
36	CSNK1G2	0.98473052
37	CSNK1G3	0.96516703
38	BMPR1B	0.95780571
39	MAP2K7	0.93551865
40	OXSR1	0.92020514
41	TYRO3	0.90363679
42	CHEK2	0.89925563
43	PTK2B	0.89484225
44	INSRR	0.87696425
45	FER	0.86891126
46	DYRK1B	0.86858680
47	RIPK4	0.85787311
48	KDR	0.82702332
49	BMPR2	0.76542862
50	CAMK1	0.75908859
51	PLK2	0.74971146
52	CAMK2G	0.74537587
53	BCKDK	0.72807327
54	CDK4	0.70905486
55	CAMK4	0.69071490
56	MAP3K12	0.68969237
57	TRIM28	0.68532258
58	MAPK7	0.67590799
59	EPHA3	0.65045762
60	SIK3	0.64455330
61	SGK2	0.64288912
62	PRKCE	0.63336664
63	MUSK	0.63289765
64	PRKG1	0.59789977
65	AURKA	0.59512194
66	LIMK1	0.58898983
67	MAPKAPK3	0.56913824
68	CCNB1	0.56594802
69	SYK	0.56266583
70	MYLK	0.55088429
71	MARK3	0.52777569
72	MAP2K2	0.50075511
73	PKN1	0.49812691
74	RPS6KA5	0.48882868
75	TRPM7	0.47985719
76	ERBB3	0.47869423
77	VRK1	0.46816114
78	PRKAA2	0.46397290
79	SGK1	0.43694660
80	PRKACA	0.42906281
81	ERBB2	0.42406101
82	NLK	0.42153824
83	MAP3K7	0.41648693
84	DYRK2	0.40075616
85	STK38	0.40054189
86	PRKCG	0.38757920
87	MAP2K1	0.37236489
88	BTK	0.34945131
89	ACVR1B	0.34353547
90	PRKCA	0.33776203
91	MAPK12	0.33568559
92	TAF1	0.33214047
93	PRKAA1	0.32814599
94	SGK223	0.30740164
95	SGK494	0.30740164
96	ADRBK1	0.30704252
97	PLK4	0.30197688
98	STK11	0.30030288
99	PRKACG	0.29515663
100	FES	0.29324726

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	2.96065493
2	Regulation of autophagy_Homo sapiens_hsa04140	2.93152904
3	Tight junction_Homo sapiens_hsa04530	2.91116565
4	Olfactory transduction_Homo sapiens_hsa04740	2.67175914
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.18840517
6	Circadian entrainment_Homo sapiens_hsa04713	2.06874610
7	Phototransduction_Homo sapiens_hsa04744	2.00014018
8	Morphine addiction_Homo sapiens_hsa05032	1.99277849
9	Circadian rhythm_Homo sapiens_hsa04710	1.92804701
10	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.87612322
11	Calcium signaling pathway_Homo sapiens_hsa04020	1.82568944
12	Nicotine addiction_Homo sapiens_hsa05033	1.75016204
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.72214933
14	Renin secretion_Homo sapiens_hsa04924	1.69658658
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.66007227
16	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.65570888
17	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.64908333
18	GABAergic synapse_Homo sapiens_hsa04727	1.61290503
19	Caffeine metabolism_Homo sapiens_hsa00232	1.60728188
20	Insulin secretion_Homo sapiens_hsa04911	1.59012773
21	Gastric acid secretion_Homo sapiens_hsa04971	1.54909870
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.53490019
23	Platelet activation_Homo sapiens_hsa04611	1.53146754
24	Chemical carcinogenesis_Homo sapiens_hsa05204	1.45751678
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.44478386
26	Serotonergic synapse_Homo sapiens_hsa04726	1.41727173
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.37783079
28	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.37575145
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.35621601
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.33947146
31	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.25513233
32	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.24883820
33	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.23133112
34	Dopaminergic synapse_Homo sapiens_hsa04728	1.21681283
35	Taste transduction_Homo sapiens_hsa04742	1.20808114
36	Long-term depression_Homo sapiens_hsa04730	1.20056363
37	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.16870304
38	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.16834563
39	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.13626626
40	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.13236845
41	Salivary secretion_Homo sapiens_hsa04970	1.09071750
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.08486100
43	Retinol metabolism_Homo sapiens_hsa00830	1.06992409
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.05924582
45	Pancreatic secretion_Homo sapiens_hsa04972	1.00785958
46	Amphetamine addiction_Homo sapiens_hsa05031	1.00651679
47	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.00558697
48	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.99702698
49	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.99138050
50	Glutamatergic synapse_Homo sapiens_hsa04724	0.97162887
51	RNA degradation_Homo sapiens_hsa03018	0.96048595
52	Asthma_Homo sapiens_hsa05310	0.95505144
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.91768649
54	Oxidative phosphorylation_Homo sapiens_hsa00190	0.90472479
55	Sulfur metabolism_Homo sapiens_hsa00920	0.87352969
56	Ether lipid metabolism_Homo sapiens_hsa00565	0.86927798
57	Basal transcription factors_Homo sapiens_hsa03022	0.86041608
58	Alcoholism_Homo sapiens_hsa05034	0.84231381
59	Butanoate metabolism_Homo sapiens_hsa00650	0.84225807
60	Glucagon signaling pathway_Homo sapiens_hsa04922	0.83055311
61	Cholinergic synapse_Homo sapiens_hsa04725	0.82100629
62	Alzheimers disease_Homo sapiens_hsa05010	0.80694775
63	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.80607866
64	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.80259072
65	ABC transporters_Homo sapiens_hsa02010	0.79671869
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.78915468
67	Fanconi anemia pathway_Homo sapiens_hsa03460	0.77455831
68	cAMP signaling pathway_Homo sapiens_hsa04024	0.75561744
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74869144
70	Wnt signaling pathway_Homo sapiens_hsa04310	0.71247088
71	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.69841192
72	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.65121514
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.65076603
74	Protein export_Homo sapiens_hsa03060	0.62870762
75	Parkinsons disease_Homo sapiens_hsa05012	0.60937634
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.59407629
77	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.58595360
78	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.58254235
79	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.58212402
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.54649078
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.53756248
82	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.52892083
83	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.51487616
84	Allograft rejection_Homo sapiens_hsa05330	0.50674887
85	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.50652885
86	Arginine biosynthesis_Homo sapiens_hsa00220	0.47716595
87	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.47522535
88	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.47070792
89	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.46413378
90	Peroxisome_Homo sapiens_hsa04146	0.46195437
91	Oocyte meiosis_Homo sapiens_hsa04114	0.44644723
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40636494
93	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.40405283
94	Adherens junction_Homo sapiens_hsa04520	0.39445455
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38396902
96	Type I diabetes mellitus_Homo sapiens_hsa04940	0.37836884
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.37466904
98	Long-term potentiation_Homo sapiens_hsa04720	0.36056695
99	Rheumatoid arthritis_Homo sapiens_hsa05323	0.35921144
100	Graft-versus-host disease_Homo sapiens_hsa05332	0.34867164

MTRNR2L13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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