ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	long-chain fatty acid biosynthetic process (GO:0042759)	8.99886710
2	multicellular organismal water homeostasis (GO:0050891)	8.99431964
3	keratinocyte differentiation (GO:0030216)	8.22488934
4	water homeostasis (GO:0030104)	7.60145871
5	peptide cross-linking (GO:0018149)	6.76787971
6	lipoxygenase pathway (GO:0019372)	6.71316466
7	linoleic acid metabolic process (GO:0043651)	6.51967553
8	epidermal cell differentiation (GO:0009913)	6.23836206
9	keratinocyte proliferation (GO:0043616)	6.00200477
10	skin morphogenesis (GO:0043589)	5.81920650
11	desmosome organization (GO:0002934)	5.52992797
12	epidermis development (GO:0008544)	5.36527518
13	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.28350574
14	detection of bacterium (GO:0016045)	4.95905655
15	regulation of natural killer cell differentiation (GO:0032823)	4.65700843
16	detection of other organism (GO:0098543)	4.61729854
17	establishment of protein localization to Golgi (GO:0072600)	4.49233875
18	polarized epithelial cell differentiation (GO:0030859)	4.36775396
19	protein targeting to Golgi (GO:0000042)	4.34941387
20	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.25151055
21	phosphatidylinositol acyl-chain remodeling (GO:0036149)	4.13567742
22	lateral sprouting from an epithelium (GO:0060601)	4.12168715
23	sperm motility (GO:0030317)	4.12162726
24	surfactant homeostasis (GO:0043129)	4.06703385
25	acrosome reaction (GO:0007340)	3.92587106
26	microtubule depolymerization (GO:0007019)	3.90071145
27	negative regulation of interferon-gamma production (GO:0032689)	3.81658728
28	protein polyglutamylation (GO:0018095)	3.79588766
29	phospholipid efflux (GO:0033700)	3.78318902
30	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.76510170
31	chemical homeostasis within a tissue (GO:0048875)	3.72527217
32	microtubule nucleation (GO:0007020)	3.71994718
33	gap junction assembly (GO:0016264)	3.63853797
34	fusion of sperm to egg plasma membrane (GO:0007342)	3.58003484
35	ectoderm development (GO:0007398)	3.56714439
36	establishment of planar polarity (GO:0001736)	3.54481050
37	establishment of tissue polarity (GO:0007164)	3.54481050
38	negative regulation of interleukin-17 production (GO:0032700)	3.47321107
39	ceramide biosynthetic process (GO:0046513)	3.38742049
40	positive regulation of monocyte chemotaxis (GO:0090026)	3.28473779
41	microtubule polymerization or depolymerization (GO:0031109)	3.28140267
42	positive regulation of cholesterol efflux (GO:0010875)	3.26545346
43	regulation of protein localization to cell surface (GO:2000008)	3.21108419
44	protein localization to Golgi apparatus (GO:0034067)	3.21063852
45	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.17418634
46	intermediate filament cytoskeleton organization (GO:0045104)	3.13879680
47	single strand break repair (GO:0000012)	3.12452265
48	thrombin receptor signaling pathway (GO:0070493)	3.06241058
49	intermediate filament-based process (GO:0045103)	3.04643740
50	keratinization (GO:0031424)	24.2785720
51	positive regulation of sterol transport (GO:0032373)	2.86666290
52	positive regulation of cholesterol transport (GO:0032376)	2.86666290
53	response to pheromone (GO:0019236)	2.82426136
54	molting cycle (GO:0042303)	2.81215667
55	hair cycle (GO:0042633)	2.81215667
56	plasma membrane fusion (GO:0045026)	2.80289607
57	arginine catabolic process (GO:0006527)	2.77815724
58	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.73697339
59	one-carbon compound transport (GO:0019755)	2.67144661
60	genitalia morphogenesis (GO:0035112)	2.64289775
61	somite development (GO:0061053)	2.63738997
62	sympathetic nervous system development (GO:0048485)	2.59472658
63	keratinocyte development (GO:0003334)	2.58959649
64	positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)	2.56094296
65	sphingolipid biosynthetic process (GO:0030148)	2.55143198
66	epithelium development (GO:0060429)	2.54708769
67	regulation of T cell chemotaxis (GO:0010819)	2.53002304
68	positive regulation of T cell chemotaxis (GO:0010820)	2.53002304
69	intermediate filament organization (GO:0045109)	2.50850003
70	sequestering of metal ion (GO:0051238)	2.49951929
71	centriole replication (GO:0007099)	2.49236031
72	ventricular cardiac muscle cell action potential (GO:0086005)	2.48607019
73	regulation of lipoprotein metabolic process (GO:0050746)	2.48209783
74	multicellular organism reproduction (GO:0032504)	2.45182908
75	regulation of cholesterol efflux (GO:0010874)	2.44728796
76	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.44448933
77	fatty acid elongation (GO:0030497)	2.39853162
78	detection of external biotic stimulus (GO:0098581)	2.35991133
79	regulation of neuron projection regeneration (GO:0070570)	2.35412946
80	regulation of axon regeneration (GO:0048679)	2.35412946
81	calcium ion-dependent exocytosis (GO:0017156)	2.28262087
82	homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)	2.26862338
83	morphogenesis of an epithelial fold (GO:0060571)	2.24181319
84	epithelial cilium movement (GO:0003351)	2.24013614
85	seminiferous tubule development (GO:0072520)	2.23857371
86	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	2.22999791
87	regulation of cilium movement (GO:0003352)	2.22564791
88	vesicle transport along microtubule (GO:0047496)	2.20985841
89	regulation of natural killer cell activation (GO:0032814)	2.20674219
90	regulation of monocyte chemotaxis (GO:0090025)	2.20609175
91	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.20282132
92	phosphatidylserine metabolic process (GO:0006658)	2.18642644
93	intra-Golgi vesicle-mediated transport (GO:0006891)	2.17378445
94	fibrinolysis (GO:0042730)	2.17123490
95	membrane lipid biosynthetic process (GO:0046467)	2.15592544
96	negative regulation of vascular permeability (GO:0043116)	2.15244099
97	axonemal dynein complex assembly (GO:0070286)	2.15063577
98	spermatid development (GO:0007286)	2.13082770
99	establishment of skin barrier (GO:0061436)	17.5387776
100	regulation of water loss via skin (GO:0033561)	14.6130757

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.62399710
2	GBX2_23144817_ChIP-Seq_PC3_Human	2.49781136
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.24501870
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.13409078
5	AR_21572438_ChIP-Seq_LNCaP_Human	2.12145620
6	FUS_26573619_Chip-Seq_HEK293_Human	2.10435680
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04773219
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.04182034
9	SMAD4_21799915_ChIP-Seq_A2780_Human	2.02074390
10	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.92107034
11	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.90823008
12	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.79966308
13	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.79966308
14	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.79245698
15	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.78827804
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.77095015
17	P300_19829295_ChIP-Seq_ESCs_Human	1.76622938
18	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.75917035
19	IGF1R_20145208_ChIP-Seq_DFB_Human	1.74319844
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.71978398
21	AR_25329375_ChIP-Seq_VCAP_Human	1.71200483
22	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.70406840
23	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.70045921
24	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.69998174
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.69998174
26	TP63_23658742_ChIP-Seq_EP156T_Human	1.68897371
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.67455949
28	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.64335859
29	EZH2_22144423_ChIP-Seq_EOC_Human	1.64264593
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.60344281
31	TP53_18474530_ChIP-ChIP_U2OS_Human	1.60158531
32	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.59088654
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.58437518
34	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.57346384
35	STAT3_23295773_ChIP-Seq_U87_Human	1.56115553
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.42907851
37	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.40561619
38	TCF4_22108803_ChIP-Seq_LS180_Human	1.38535955
39	ERG_20517297_ChIP-Seq_VCAP_Human	1.38028016
40	AHR_22903824_ChIP-Seq_MCF-7_Human	1.36622381
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.36361336
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35897051
43	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.35662025
44	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.33031537
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31640396
46	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31540009
47	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.30659636
48	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.29538718
49	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.29441915
50	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.28656348
51	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.27600602
52	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.27246699
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.27099603
54	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.26812349
55	HTT_18923047_ChIP-ChIP_STHdh_Human	1.26688308
56	CJUN_26792858_Chip-Seq_BT549_Human	1.26523946
57	TCF4_23295773_ChIP-Seq_U87_Human	1.26352640
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26060288
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24044218
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.23707302
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22978200
62	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.19977437
63	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.19784835
64	BCAT_22108803_ChIP-Seq_LS180_Human	1.19779569
65	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.19418620
66	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.17632057
67	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.16534069
68	RBPJ_21746931_ChIP-Seq_IB4_Human	1.16437304
69	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.16410818
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.15411023
71	VDR_22108803_ChIP-Seq_LS180_Human	1.15167883
72	TBL1_22424771_ChIP-Seq_293T_Human	1.14413637
73	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12844071
74	NCOR_22424771_ChIP-Seq_293T_Human	1.12802889
75	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.12206559
76	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.11844138
77	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10950297
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10950297
79	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.10899591
80	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.10561891
81	RXR_22108803_ChIP-Seq_LS180_Human	1.10382068
82	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09194623
83	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.09174774
84	ETV1_20927104_ChIP-Seq_GIST48_Human	1.08905242
85	TAF2_19829295_ChIP-Seq_ESCs_Human	1.08859760
86	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.08246829
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07590088
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.07514663
89	ZNF274_21170338_ChIP-Seq_K562_Hela	1.07446585
90	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.07301836
91	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.06357866
92	CDX2_22108803_ChIP-Seq_LS180_Human	1.06234482
93	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05979701
94	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05834847
95	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.05049390
96	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.04887680
97	RUNX2_22187159_ChIP-Seq_PCA_Human	1.04367222
98	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.04243491
99	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.03632912
100	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.02864180

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005275_abnormal_skin_tensile	7.16531055
2	MP0005501_abnormal_skin_physiology	5.87355195
3	MP0005377_hearing/vestibular/ear_phenot	4.12396603
4	MP0003878_abnormal_ear_physiology	4.12396603
5	MP0003941_abnormal_skin_development	4.02773210
6	MP0000579_abnormal_nail_morphology	3.90307655
7	MP0004885_abnormal_endolymph	3.28079007
8	MP0003191_abnormal_cellular_cholesterol	2.85280249
9	MP0010771_integument_phenotype	2.61204389
10	MP0001216_abnormal_epidermal_layer	2.36886493
11	MP0001188_hyperpigmentation	2.15977507
12	MP0004782_abnormal_surfactant_physiolog	2.11236332
13	MP0004947_skin_inflammation	2.04436241
14	MP0003011_delayed_dark_adaptation	2.00000696
15	MP0002796_impaired_skin_barrier	10.6167689
16	MP0005410_abnormal_fertilization	1.91439190
17	MP0000465_gastrointestinal_hemorrhage	1.72817320
18	MP0000647_abnormal_sebaceous_gland	1.66599388
19	MP0000377_abnormal_hair_follicle	1.66008630
20	MP0002060_abnormal_skin_morphology	1.64054952
21	MP0003453_abnormal_keratinocyte_physiol	1.61911030
22	MP0001191_abnormal_skin_condition	1.61630398
23	MP0002098_abnormal_vibrissa_morphology	1.43451295
24	MP0005409_darkened_coat_color	1.30923033
25	MP0010234_abnormal_vibrissa_follicle	1.29999329
26	MP0010678_abnormal_skin_adnexa	1.29614816
27	MP0008004_abnormal_stomach_pH	1.25408112
28	MP0000383_abnormal_hair_follicle	1.25351889
29	MP0009931_abnormal_skin_appearance	1.24498854
30	MP0005670_abnormal_white_adipose	1.23905058
31	MP0010352_gastrointestinal_tract_polyps	1.23888209
32	MP0002234_abnormal_pharynx_morphology	1.21276081
33	MP0004084_abnormal_cardiac_muscle	1.21234500
34	MP0001485_abnormal_pinna_reflex	1.20495120
35	MP0000427_abnormal_hair_cycle	1.13778002
36	MP0004264_abnormal_extraembryonic_tissu	1.09742009
37	MP0000467_abnormal_esophagus_morphology	1.08653629
38	MP0002095_abnormal_skin_pigmentation	1.07427694
39	MP0001784_abnormal_fluid_regulation	1.06126488
40	MP0002138_abnormal_hepatobiliary_system	0.93546585
41	MP0008789_abnormal_olfactory_epithelium	0.86209811
42	MP0009697_abnormal_copulation	0.85745543
43	MP0004036_abnormal_muscle_relaxation	0.80550533
44	MP0005503_abnormal_tendon_morphology	0.80222900
45	MP0003646_muscle_fatigue	0.80213607
46	MP0000569_abnormal_digit_pigmentation	0.78254830
47	MP0001984_abnormal_olfaction	0.77887106
48	MP0005423_abnormal_somatic_nervous	0.77471005
49	MP0000566_synostosis	0.76868132
50	MP0005187_abnormal_penis_morphology	0.76460449
51	MP0004484_altered_response_of	0.75402147
52	MP0003698_abnormal_male_reproductive	0.72717978
53	MP0005499_abnormal_olfactory_system	0.71168616
54	MP0005394_taste/olfaction_phenotype	0.71168616
55	MP0000367_abnormal_coat/_hair	0.70969215
56	MP0004270_analgesia	0.68577501
57	MP0004510_myositis	0.67250717
58	MP0002736_abnormal_nociception_after	0.64575732
59	MP0001486_abnormal_startle_reflex	0.58647211
60	MP0003950_abnormal_plasma_membrane	0.57626593
61	MP0000026_abnormal_inner_ear	0.57365870
62	MP0003638_abnormal_response/metabolism_	0.55399505
63	MP0001177_atelectasis	0.54567786
64	MP0008775_abnormal_heart_ventricle	0.54402067
65	MP0009046_muscle_twitch	0.52463373
66	MP0005645_abnormal_hypothalamus_physiol	0.51068632
67	MP0005167_abnormal_blood-brain_barrier	0.50960029
68	MP0001968_abnormal_touch/_nociception	0.50211398
69	MP0003566_abnormal_cell_adhesion	0.49302107
70	MP0005464_abnormal_platelet_physiology	0.48285029
71	MP0003879_abnormal_hair_cell	0.47465680
72	MP0003633_abnormal_nervous_system	0.47408974
73	MP0002282_abnormal_trachea_morphology	0.47165848
74	MP0005646_abnormal_pituitary_gland	0.46543553
75	MP0000762_abnormal_tongue_morphology	0.45335480
76	MP0005253_abnormal_eye_physiology	0.44214837
77	MP0006276_abnormal_autonomic_nervous	0.44193015
78	MP0001929_abnormal_gametogenesis	0.44191706
79	MP0004859_abnormal_synaptic_plasticity	0.43664142
80	MP0004142_abnormal_muscle_tone	0.43493597
81	MP0009053_abnormal_anal_canal	0.39862671
82	MP0002177_abnormal_outer_ear	0.39034310
83	MP0001879_abnormal_lymphatic_vessel	0.38418539
84	MP0001502_abnormal_circadian_rhythm	0.38400312
85	MP0008569_lethality_at_weaning	0.37789656
86	MP0005248_abnormal_Harderian_gland	0.37271465
87	MP0009115_abnormal_fat_cell	0.36667244
88	MP0002733_abnormal_thermal_nociception	0.36584404
89	MP0000230_abnormal_systemic_arterial	0.36114630
90	MP0001243_abnormal_dermal_layer	0.36086722
91	MP0002572_abnormal_emotion/affect_behav	0.35606358
92	MP0005551_abnormal_eye_electrophysiolog	0.35546164
93	MP0001905_abnormal_dopamine_level	0.35210122
94	MP0001963_abnormal_hearing_physiology	0.35104928
95	MP0002127_abnormal_cardiovascular_syste	0.33260824
96	MP0004197_abnormal_fetal_growth/weight/	0.33142377
97	MP0002653_abnormal_ependyma_morphology	0.30610684
98	MP0001340_abnormal_eyelid_morphology	0.30457369
99	MP0003718_maternal_effect	0.30115834
100	MP0005620_abnormal_muscle_contractility	0.30027354

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased IgE level (HP:0003212)	8.35773771
2	Onycholysis (HP:0001806)	7.38678398
3	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	7.33748545
4	Congenital ichthyosiform erythroderma (HP:0007431)	7.17196554
5	Abnormality of the axillary hair (HP:0100134)	7.07835590
6	Abnormality of secondary sexual hair (HP:0009888)	7.07835590
7	Alopecia of scalp (HP:0002293)	6.44587858
8	Corneal erosion (HP:0200020)	6.23586216
9	Erythroderma (HP:0001019)	6.21912126
10	Palmoplantar hyperkeratosis (HP:0000972)	5.86454940
11	Hypotrichosis (HP:0001006)	5.79122180
12	Palmar hyperkeratosis (HP:0010765)	5.64456048
13	Ectropion (HP:0000656)	4.69148932
14	Hypohidrosis (HP:0000966)	4.66315971
15	Plantar hyperkeratosis (HP:0007556)	4.46565583
16	Erythema (HP:0010783)	4.46203010
17	Parakeratosis (HP:0001036)	4.45574345
18	Absent eyelashes (HP:0000561)	4.34273252
19	Absent hair (HP:0002298)	4.21333084
20	Gangrene (HP:0100758)	4.18627205
21	Palmoplantar keratoderma (HP:0000982)	3.77878743
22	Oral leukoplakia (HP:0002745)	3.62703798
23	Right ventricular cardiomyopathy (HP:0011663)	3.46859837
24	Split foot (HP:0001839)	3.40312579
25	Thick nail (HP:0001805)	3.40024981
26	Autoamputation (HP:0001218)	3.37931914
27	Sparse eyelashes (HP:0000653)	3.11014892
28	Abnormality of placental membranes (HP:0011409)	3.09929240
29	Amniotic constriction ring (HP:0009775)	3.09929240
30	Pruritus (HP:0000989)	3.02611424
31	Depressed nasal tip (HP:0000437)	2.88152380
32	Lip pit (HP:0100267)	2.87551628
33	Furrowed tongue (HP:0000221)	2.80450266
34	Hypoplastic labia majora (HP:0000059)	2.79906295
35	Woolly hair (HP:0002224)	2.62660027
36	Nail dystrophy (HP:0008404)	2.60957954
37	Abnormality of the labia majora (HP:0012881)	2.52916921
38	Sparse scalp hair (HP:0002209)	2.49530290
39	Recurrent corneal erosions (HP:0000495)	2.44083035
40	Malignant hyperthermia (HP:0002047)	2.38053374
41	Lack of skin elasticity (HP:0100679)	2.34039593
42	Fair hair (HP:0002286)	2.31610271
43	Prolonged bleeding time (HP:0003010)	2.29285889
44	Increased mean platelet volume (HP:0011877)	2.28645046
45	Septate vagina (HP:0001153)	2.24082084
46	Paralysis (HP:0003470)	2.22886173
47	Abnormality of the salivary glands (HP:0010286)	2.22585334
48	Slow-growing hair (HP:0002217)	2.21096416
49	Abnormality of hair growth rate (HP:0011363)	2.21096416
50	Anhidrosis (HP:0000970)	2.19007397
51	Menorrhagia (HP:0000132)	2.17205609
52	Blepharitis (HP:0000498)	2.15822541
53	Petechiae (HP:0000967)	2.14922408
54	Abnormality of the renal collecting system (HP:0004742)	2.12770220
55	Duplicated collecting system (HP:0000081)	2.04249947
56	Abnormal platelet volume (HP:0011876)	2.00345533
57	Abnormality of nail color (HP:0100643)	11.0999093
58	Hyperkalemia (HP:0002153)	1.96500146
59	Curly hair (HP:0002212)	1.92179850
60	Gingival bleeding (HP:0000225)	1.91745762
61	Dehydration (HP:0001944)	1.90034445
62	Labial hypoplasia (HP:0000066)	1.88904170
63	Acanthocytosis (HP:0001927)	1.88387800
64	Asthma (HP:0002099)	1.77947098
65	Renal dysplasia (HP:0000110)	1.76519527
66	Hypergammaglobulinemia (HP:0010702)	1.74874198
67	Generalized hypopigmentation of hair (HP:0011358)	1.74778047
68	Dry skin (HP:0000958)	1.72719370
69	Breast hypoplasia (HP:0003187)	1.72707191
70	Fine hair (HP:0002213)	1.72605001
71	Tubulointerstitial nephritis (HP:0001970)	1.70422443
72	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.67555505
73	Cone-rod dystrophy (HP:0000548)	1.66659619
74	Hypoplastic female external genitalia (HP:0012815)	1.65249859
75	Poikilocytosis (HP:0004447)	1.64561766
76	Abnormal hair laboratory examination (HP:0003328)	1.57231153
77	Melanocytic nevus (HP:0000995)	1.55112396
78	Purpura (HP:0000979)	1.54409007
79	Keratoconjunctivitis sicca (HP:0001097)	1.52611093
80	Pustule (HP:0200039)	1.52491400
81	Neoplasm of the heart (HP:0100544)	1.52458436
82	Absent/shortened dynein arms (HP:0200106)	1.50645105
83	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.50645105
84	Growth hormone deficiency (HP:0000824)	1.48031928
85	Failure to thrive in infancy (HP:0001531)	1.46343932
86	Chronic hepatic failure (HP:0100626)	1.45341320
87	Hydroureter (HP:0000072)	1.45297643
88	Urticaria (HP:0001025)	1.44472288
89	Multifactorial inheritance (HP:0001426)	1.43792987
90	Brittle hair (HP:0002299)	1.43570388
91	Progressive cerebellar ataxia (HP:0002073)	1.43350941
92	Keratoconjunctivitis (HP:0001096)	1.42590414
93	Sepsis (HP:0100806)	1.40712413
94	Hamartoma (HP:0010566)	1.39357261
95	Generalized hyperpigmentation (HP:0007440)	1.39339395
96	Skin tags (HP:0010609)	1.38910570
97	Papillary thyroid carcinoma (HP:0002895)	1.38334656
98	Absent hand (HP:0004050)	1.37827544
99	Blue irides (HP:0000635)	1.37419707
100	Abnormality of the nasal septum (HP:0000419)	1.37135552

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PIK3CG	3.75255707
2	TGFBR1	3.73078990
3	PLK4	3.64151556
4	MAP3K4	2.47370285
5	INSRR	2.26821497
6	BRD4	2.20325616
7	OBSCN	2.11039172
8	MARK1	2.09131817
9	FER	2.07416259
10	AKT3	2.07182599
11	PLK2	1.99527015
12	MAP4K2	1.94332046
13	CAMK1G	1.94006813
14	CSNK1A1L	1.87147048
15	BCR	1.82804189
16	STK38L	1.80225402
17	WNK1	1.78283221
18	MAP2K7	1.78004414
19	TAOK3	1.56115822
20	PNCK	1.55504940
21	FRK	1.47776049
22	TRIM28	1.43834011
23	CDK12	1.41808624
24	CASK	1.34524840
25	STK39	1.33112079
26	SGK2	1.31428059
27	CSNK1G3	1.31109623
28	MET	1.29277561
29	BMPR1B	1.23940473
30	MST4	1.19469763
31	ERBB3	1.19441565
32	FGFR1	1.19325883
33	EPHA3	1.18206476
34	STK38	1.17629869
35	CSNK1G2	1.16133419
36	SGK223	1.15033181
37	SGK494	1.15033181
38	TYRO3	1.13703827
39	TESK1	1.11159863
40	MAP2K4	1.09164473
41	PINK1	1.08944934
42	CSNK1G1	1.02107931
43	MAP3K6	0.99613508
44	MAPK13	0.99144516
45	WNK3	0.96395750
46	WNK4	0.88318384
47	DYRK1B	0.87352105
48	DMPK	0.84684017
49	MINK1	0.84429512
50	CDK19	0.81868583
51	DDR2	0.78563340
52	PTK2B	0.75301451
53	DYRK2	0.74612213
54	CAMK1	0.74308283
55	PKN1	0.73543096
56	MARK2	0.72314010
57	EPHA4	0.71761160
58	PDK1	0.70846920
59	CAMK1D	0.70720186
60	CAMK4	0.70705048
61	PRKCG	0.70105721
62	SGK3	0.69236361
63	PRKD3	0.69046372
64	NTRK2	0.68596154
65	STK3	0.68564500
66	FLT3	0.68401246
67	ADRBK2	0.67609557
68	PIM2	0.67293507
69	SIK3	0.63440342
70	OXSR1	0.63274781
71	BCKDK	0.59689062
72	PDPK1	0.58531291
73	MAP3K5	0.56865874
74	PAK3	0.55627445
75	STK24	0.54605395
76	PRKCE	0.53320086
77	PRKAA2	0.53298731
78	PIK3CA	0.52208596
79	TXK	0.51989924
80	PRKG1	0.50621115
81	NTRK3	0.48207104
82	SGK1	0.47363937
83	TNIK	0.44750376
84	MAP3K2	0.44331951
85	CDK8	0.44087055
86	CDK3	0.43165184
87	BMX	0.42657354
88	SYK	0.42004126
89	IKBKB	0.40906041
90	MAP3K9	0.40794686
91	RPS6KB1	0.40553366
92	PRKAA1	0.40219644
93	TEC	0.39799909
94	PRKACA	0.39360337
95	MAPK12	0.39148730
96	NEK6	0.38468906
97	CSNK1D	0.38311136
98	MAPK7	0.38030692
99	ADRBK1	0.36189446
100	MAP3K7	0.35660484

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.08912107
2	Linoleic acid metabolism_Homo sapiens_hsa00591	3.73026936
3	Phototransduction_Homo sapiens_hsa04744	2.97127988
4	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.70814957
5	Olfactory transduction_Homo sapiens_hsa04740	2.51624441
6	Ether lipid metabolism_Homo sapiens_hsa00565	2.12367723
7	Serotonergic synapse_Homo sapiens_hsa04726	1.98506085
8	Circadian rhythm_Homo sapiens_hsa04710	1.98070326
9	ABC transporters_Homo sapiens_hsa02010	1.96935090
10	Long-term depression_Homo sapiens_hsa04730	1.81790189
11	Renin secretion_Homo sapiens_hsa04924	1.70768883
12	Platelet activation_Homo sapiens_hsa04611	1.60200085
13	Circadian entrainment_Homo sapiens_hsa04713	1.54112386
14	Nicotine addiction_Homo sapiens_hsa05033	1.52970633
15	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.51203068
16	Histidine metabolism_Homo sapiens_hsa00340	1.45087946
17	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.44064154
18	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.43971995
19	Glutamatergic synapse_Homo sapiens_hsa04724	1.40995559
20	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.39436032
21	Sphingolipid metabolism_Homo sapiens_hsa00600	1.38331196
22	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.31626590
23	Arginine biosynthesis_Homo sapiens_hsa00220	1.26963691
24	beta-Alanine metabolism_Homo sapiens_hsa00410	1.24431620
25	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.24367316
26	Choline metabolism in cancer_Homo sapiens_hsa05231	1.24272330
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.17186842
28	Arginine and proline metabolism_Homo sapiens_hsa00330	1.17144486
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.16731097
30	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.14255685
31	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.13052604
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.12162282
33	Renin-angiotensin system_Homo sapiens_hsa04614	1.11938707
34	Amphetamine addiction_Homo sapiens_hsa05031	1.11693838
35	GnRH signaling pathway_Homo sapiens_hsa04912	1.07065398
36	Taste transduction_Homo sapiens_hsa04742	1.06390862
37	Gastric acid secretion_Homo sapiens_hsa04971	1.04158311
38	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.02561748
39	Salivary secretion_Homo sapiens_hsa04970	1.02385508
40	Collecting duct acid secretion_Homo sapiens_hsa04966	1.01937345
41	Pancreatic secretion_Homo sapiens_hsa04972	1.01555985
42	Alcoholism_Homo sapiens_hsa05034	1.01367309
43	Phenylalanine metabolism_Homo sapiens_hsa00360	1.00192191
44	Adherens junction_Homo sapiens_hsa04520	0.99560998
45	cAMP signaling pathway_Homo sapiens_hsa04024	0.99515407
46	Long-term potentiation_Homo sapiens_hsa04720	0.97108233
47	Morphine addiction_Homo sapiens_hsa05032	0.96551636
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.96184586
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.95807724
50	GABAergic synapse_Homo sapiens_hsa04727	0.94976205
51	Dopaminergic synapse_Homo sapiens_hsa04728	0.93517596
52	VEGF signaling pathway_Homo sapiens_hsa04370	0.89190952
53	Nitrogen metabolism_Homo sapiens_hsa00910	0.88456167
54	Calcium signaling pathway_Homo sapiens_hsa04020	0.88000015
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.87508055
56	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.87428455
57	Ras signaling pathway_Homo sapiens_hsa04014	0.87199227
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.85135888
59	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.84757756
60	Glioma_Homo sapiens_hsa05214	0.83917889
61	Gap junction_Homo sapiens_hsa04540	0.83875261
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82922101
63	Fatty acid elongation_Homo sapiens_hsa00062	0.82880564
64	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.81218991
65	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.79623751
66	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.79612324
67	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.73069926
68	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.71923736
69	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.71625289
70	Retinol metabolism_Homo sapiens_hsa00830	0.71318599
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70499060
72	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.69619295
73	Butanoate metabolism_Homo sapiens_hsa00650	0.65871743
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65687345
75	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.63384058
76	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.62498775
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58324824
78	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.57864749
79	ECM-receptor interaction_Homo sapiens_hsa04512	0.57618914
80	Rap1 signaling pathway_Homo sapiens_hsa04015	0.57387074
81	Glucagon signaling pathway_Homo sapiens_hsa04922	0.56095089
82	Melanogenesis_Homo sapiens_hsa04916	0.55848639
83	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.52099464
84	Axon guidance_Homo sapiens_hsa04360	0.50898105
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50849472
86	Estrogen signaling pathway_Homo sapiens_hsa04915	0.48718216
87	Oocyte meiosis_Homo sapiens_hsa04114	0.47800653
88	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.47121568
89	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.46587509
90	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43610152
91	Cocaine addiction_Homo sapiens_hsa05030	0.43404626
92	PPAR signaling pathway_Homo sapiens_hsa03320	0.41821914
93	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.40224277
94	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.40208289
95	Endocytosis_Homo sapiens_hsa04144	0.40049080
96	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.39158905
97	ErbB signaling pathway_Homo sapiens_hsa04012	0.38947536
98	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.38578193
99	Wnt signaling pathway_Homo sapiens_hsa04310	0.37958842
100	Hippo signaling pathway_Homo sapiens_hsa04390	0.35790712

MTRNR2L2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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