ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	dopamine transport (GO:0015872)	7.14721425
2	phenol-containing compound catabolic process (GO:0019336)	4.79643072
3	dopamine biosynthetic process (GO:0042416)	4.77186177
4	sleep (GO:0030431)	4.37054753
5	catecholamine transport (GO:0051937)	4.27816332
6	response to gravity (GO:0009629)	4.18097801
7	DNA deamination (GO:0045006)	4.07795634
8	regulation of endothelial cell differentiation (GO:0045601)	3.83772558
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.70567882
10	NADH dehydrogenase complex assembly (GO:0010257)	3.70567882
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.70567882
12	cellular response to nicotine (GO:0071316)	3.61626625
13	positive regulation of prostaglandin secretion (GO:0032308)	3.60437976
14	regulation of skeletal muscle contraction (GO:0014819)	3.51867725
15	behavioral response to nicotine (GO:0035095)	3.50366468
16	neurotransmitter biosynthetic process (GO:0042136)	3.49045222
17	protein complex biogenesis (GO:0070271)	3.48398756
18	L-fucose catabolic process (GO:0042355)	3.43528114
19	fucose catabolic process (GO:0019317)	3.43528114
20	L-fucose metabolic process (GO:0042354)	3.43528114
21	water-soluble vitamin biosynthetic process (GO:0042364)	3.21621824
22	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.20723129
23	inositol phosphate dephosphorylation (GO:0046855)	3.20723129
24	mitochondrial respiratory chain complex assembly (GO:0033108)	3.11986500
25	positive regulation of defense response to virus by host (GO:0002230)	3.11851459
26	catecholamine biosynthetic process (GO:0042423)	3.08746776
27	catechol-containing compound biosynthetic process (GO:0009713)	3.08746776
28	monoamine transport (GO:0015844)	3.07723987
29	cellular response to exogenous dsRNA (GO:0071360)	3.04581008
30	rRNA catabolic process (GO:0016075)	3.00896786
31	positive regulation of endothelial cell differentiation (GO:0045603)	2.97836569
32	regulation of prostaglandin secretion (GO:0032306)	2.95216569
33	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.93715452
34	prenylation (GO:0097354)	2.92755804
35	protein prenylation (GO:0018342)	2.92755804
36	sulfation (GO:0051923)	2.92159022
37	norepinephrine metabolic process (GO:0042415)	2.91327873
38	regulation of germinal center formation (GO:0002634)	2.89653759
39	kynurenine metabolic process (GO:0070189)	2.89624027
40	neurotransmitter metabolic process (GO:0042133)	2.87978109
41	inositol phosphate catabolic process (GO:0071545)	2.85559703
42	alkaloid metabolic process (GO:0009820)	2.83687799
43	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.82908031
44	detection of calcium ion (GO:0005513)	2.81164224
45	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.78413680
46	adenosine metabolic process (GO:0046085)	2.78351249
47	response to xenobiotic stimulus (GO:0009410)	2.77595856
48	neuronal action potential (GO:0019228)	2.75591341
49	cytidine metabolic process (GO:0046087)	2.74859702
50	cytidine catabolic process (GO:0006216)	2.74859702
51	cytidine deamination (GO:0009972)	2.74859702
52	tryptophan metabolic process (GO:0006568)	2.73358428
53	endoderm formation (GO:0001706)	2.72592306
54	response to interferon-beta (GO:0035456)	2.70888027
55	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.70865954
56	regulation of T cell mediated cytotoxicity (GO:0001914)	2.70273135
57	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.69778349
58	ATP synthesis coupled proton transport (GO:0015986)	2.69778349
59	mannosylation (GO:0097502)	2.69577665
60	positive regulation of fatty acid transport (GO:2000193)	2.68765038
61	respiratory chain complex IV assembly (GO:0008535)	2.68451953
62	regulation of memory T cell differentiation (GO:0043380)	2.67521936
63	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.65677741
64	preassembly of GPI anchor in ER membrane (GO:0016254)	2.64847329
65	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.63251443
66	tyrosine metabolic process (GO:0006570)	2.60708173
67	benzene-containing compound metabolic process (GO:0042537)	2.60671083
68	indolalkylamine metabolic process (GO:0006586)	2.60177115
69	axoneme assembly (GO:0035082)	2.55553660
70	organic cation transport (GO:0015695)	2.55496981
71	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.54925237
72	regulation of defense response to virus by host (GO:0050691)	2.54174023
73	L-methionine salvage (GO:0071267)	2.54142425
74	L-methionine biosynthetic process (GO:0071265)	2.54142425
75	amino acid salvage (GO:0043102)	2.54142425
76	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.53530252
77	regulation of dopamine metabolic process (GO:0042053)	2.51417569
78	regulation of catecholamine metabolic process (GO:0042069)	2.51417569
79	indole-containing compound catabolic process (GO:0042436)	2.51022304
80	indolalkylamine catabolic process (GO:0046218)	2.51022304
81	tryptophan catabolic process (GO:0006569)	2.51022304
82	interferon-gamma production (GO:0032609)	2.50723481
83	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.49565048
84	platelet dense granule organization (GO:0060155)	2.49526763
85	dopamine metabolic process (GO:0042417)	2.49320419
86	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.49211033
87	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.49211033
88	electron transport chain (GO:0022900)	2.49073942
89	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.48125003
90	response to corticosterone (GO:0051412)	2.44206751
91	multicellular organism reproduction (GO:0032504)	2.43589770
92	aromatic amino acid family metabolic process (GO:0009072)	2.42467957
93	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.42381286
94	mitotic cell cycle arrest (GO:0071850)	2.41473504
95	respiratory electron transport chain (GO:0022904)	2.41435472
96	positive regulation of icosanoid secretion (GO:0032305)	2.41219070
97	cellular response to interleukin-15 (GO:0071350)	2.40124350
98	regulation of cilium movement (GO:0003352)	2.40033213
99	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	2.39017042
100	cellular ketone body metabolic process (GO:0046950)	2.38379948

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.27209219
2	VDR_22108803_ChIP-Seq_LS180_Human	3.70448766
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.77676866
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.77514681
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.36993260
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.35524150
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.33243600
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.16046110
9	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.12499301
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.04551221
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.01341682
12	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.94804437
13	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.94501936
14	IRF1_19129219_ChIP-ChIP_H3396_Human	1.94228524
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.93060450
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.92191776
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.91645292
18	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.83895658
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.77363249
20	TP53_22573176_ChIP-Seq_HFKS_Human	1.76126691
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.75424961
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73749609
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.73550734
24	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.72701941
25	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.61563953
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.61206771
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.58882243
28	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.53016870
29	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.53016870
30	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.52969932
31	AR_20517297_ChIP-Seq_VCAP_Human	1.50319936
32	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.49874672
33	GATA3_26560356_Chip-Seq_TH2_Human	1.48341495
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.42338496
35	NANOG_19829295_ChIP-Seq_ESCs_Human	1.41004443
36	SOX2_19829295_ChIP-Seq_ESCs_Human	1.41004443
37	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.39240145
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.38441213
39	FUS_26573619_Chip-Seq_HEK293_Human	1.38055515
40	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.36381206
41	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.36254001
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.36191614
43	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.35100097
44	P300_19829295_ChIP-Seq_ESCs_Human	1.33769926
45	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.30322583
46	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.29924632
47	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.29911964
48	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21667551
49	ELK1_19687146_ChIP-ChIP_HELA_Human	1.20942060
50	SMAD4_21799915_ChIP-Seq_A2780_Human	1.20671920
51	RUNX_20019798_ChIP-Seq_JUKART_Human	1.20008806
52	HOXB7_26014856_ChIP-Seq_BT474_Human	1.19903939
53	CDX2_22108803_ChIP-Seq_LS180_Human	1.17617379
54	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.17439894
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.17021549
56	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.16431678
57	ERG_20517297_ChIP-Seq_VCAP_Human	1.15558050
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.15109058
59	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.14827725
60	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.14180630
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14089454
62	AR_25329375_ChIP-Seq_VCAP_Human	1.13334382
63	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.13263191
64	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12997133
65	CBP_20019798_ChIP-Seq_JUKART_Human	1.12997133
66	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12921641
67	EWS_26573619_Chip-Seq_HEK293_Human	1.11129753
68	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.10438564
69	STAT3_23295773_ChIP-Seq_U87_Human	1.10174273
70	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.09284538
71	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08885135
72	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.08667336
73	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.07514450
74	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.06761664
75	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06133827
76	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.05390762
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.04995720
78	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03997884
79	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.02202048
80	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.02179180
81	TCF4_22108803_ChIP-Seq_LS180_Human	1.01906452
82	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00770762
83	TCF4_23295773_ChIP-Seq_U87_Human	1.00309404
84	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.00131875
85	FOXP3_21729870_ChIP-Seq_TREG_Human	1.00002485
86	MYC_19829295_ChIP-Seq_ESCs_Human	0.99776362
87	GATA3_26560356_Chip-Seq_TH1_Human	0.98388885
88	GATA4_25053715_ChIP-Seq_YYC3_Human	0.98114260
89	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.97024280
90	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.96935956
91	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96019542
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95772013
93	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.95344628
94	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.94534963
95	CJUN_26792858_Chip-Seq_BT549_Human	0.94375030
96	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.93405931
97	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.92462728
98	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.92184670
99	GATA3_27048872_Chip-Seq_THYMUS_Human	0.92007239
100	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.91848802

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008872_abnormal_physiological_respon	3.17984933
2	MP0002837_dystrophic_cardiac_calcinosis	2.62170060
3	MP0009046_muscle_twitch	2.54495422
4	MP0001905_abnormal_dopamine_level	2.46283449
5	MP0003195_calcinosis	2.41621979
6	MP0003724_increased_susceptibility_to	2.38049507
7	MP0004043_abnormal_pH_regulation	2.36889000
8	MP0006072_abnormal_retinal_apoptosis	2.36350187
9	MP0002876_abnormal_thyroid_physiology	2.32905074
10	MP0005671_abnormal_response_to	2.29322602
11	MP0008875_abnormal_xenobiotic_pharmacok	2.26250177
12	MP0003646_muscle_fatigue	2.11612967
13	MP0002138_abnormal_hepatobiliary_system	2.05786002
14	MP0008775_abnormal_heart_ventricle	1.97205187
15	MP0000465_gastrointestinal_hemorrhage	1.83892355
16	MP0009697_abnormal_copulation	1.82978556
17	MP0004147_increased_porphyrin_level	1.81269422
18	MP0005646_abnormal_pituitary_gland	1.80644127
19	MP0009764_decreased_sensitivity_to	1.80541950
20	MP0002166_altered_tumor_susceptibility	1.79839987
21	MP0004215_abnormal_myocardial_fiber	1.75971629
22	MP0000013_abnormal_adipose_tissue	1.73897254
23	MP0005084_abnormal_gallbladder_morpholo	1.73848380
24	MP0009780_abnormal_chondrocyte_physiolo	1.73756015
25	MP0001835_abnormal_antigen_presentation	1.66347368
26	MP0004145_abnormal_muscle_electrophysio	1.65268862
27	MP0001765_abnormal_ion_homeostasis	1.57666850
28	MP0005253_abnormal_eye_physiology	1.56116551
29	MP0002102_abnormal_ear_morphology	1.48092208
30	MP0000685_abnormal_immune_system	1.46385569
31	MP0002148_abnormal_hypersensitivity_rea	1.46309033
32	MP0005551_abnormal_eye_electrophysiolog	1.44433107
33	MP0002006_tumorigenesis	1.42876308
34	MP0004084_abnormal_cardiac_muscle	1.41585020
35	MP0002163_abnormal_gland_morphology	1.40844643
36	MP0008877_abnormal_DNA_methylation	1.40207517
37	MP0003950_abnormal_plasma_membrane	1.39870110
38	MP0005360_urolithiasis	1.39597975
39	MP0005410_abnormal_fertilization	1.38317642
40	MP0005645_abnormal_hypothalamus_physiol	1.34907137
41	MP0001661_extended_life_span	1.33776481
42	MP0006036_abnormal_mitochondrial_physio	1.33240616
43	MP0005365_abnormal_bile_salt	1.33213805
44	MP0002272_abnormal_nervous_system	1.32441312
45	MP0000569_abnormal_digit_pigmentation	1.27694554
46	MP0005000_abnormal_immune_tolerance	1.27628224
47	MP0005332_abnormal_amino_acid	1.27087021
48	MP0000230_abnormal_systemic_arterial	1.26676128
49	MP0002332_abnormal_exercise_endurance	1.26635146
50	MP0003786_premature_aging	1.25509821
51	MP0010329_abnormal_lipoprotein_level	1.24956585
52	MP0001968_abnormal_touch/_nociception	1.24862243
53	MP0001800_abnormal_humoral_immune	1.22614897
54	MP0002638_abnormal_pupillary_reflex	1.20929743
55	MP0004484_altered_response_of	1.19119172
56	MP0005085_abnormal_gallbladder_physiolo	1.17990344
57	MP0001501_abnormal_sleep_pattern	1.17337089
58	MP0003252_abnormal_bile_duct	1.17135844
59	MP0001986_abnormal_taste_sensitivity	1.15470476
60	MP0002009_preneoplasia	1.12236765
61	MP0005636_abnormal_mineral_homeostasis	1.11274965
62	MP0004142_abnormal_muscle_tone	1.10801600
63	MP0001879_abnormal_lymphatic_vessel	1.09959767
64	MP0002723_abnormal_immune_serum	1.09447123
65	MP0002736_abnormal_nociception_after	1.06252114
66	MP0001756_abnormal_urination	1.05017847
67	MP0006276_abnormal_autonomic_nervous	1.03016746
68	MP0002452_abnormal_antigen_presenting	1.00801950
69	MP0009745_abnormal_behavioral_response	1.00502988
70	MP0000427_abnormal_hair_cycle	1.00068509
71	MP0005379_endocrine/exocrine_gland_phen	0.99932547
72	MP0009643_abnormal_urine_homeostasis	0.99798491
73	MP0009785_altered_susceptibility_to	0.98525522
74	MP0005165_increased_susceptibility_to	0.98348219
75	MP0010386_abnormal_urinary_bladder	0.97868929
76	MP0004885_abnormal_endolymph	0.97059975
77	MP0005167_abnormal_blood-brain_barrier	0.96550375
78	MP0005389_reproductive_system_phenotype	0.96414388
79	MP0003806_abnormal_nucleotide_metabolis	0.95882727
80	MP0004036_abnormal_muscle_relaxation	0.95278165
81	MP0000749_muscle_degeneration	0.93823679
82	MP0001873_stomach_inflammation	0.92474379
83	MP0002693_abnormal_pancreas_physiology	0.90867038
84	MP0003763_abnormal_thymus_physiology	0.90484218
85	MP0001790_abnormal_immune_system	0.89272754
86	MP0005387_immune_system_phenotype	0.89272754
87	MP0005670_abnormal_white_adipose	0.89091063
88	MP0002139_abnormal_hepatobiliary_system	0.85850884
89	MP0001845_abnormal_inflammatory_respons	0.84754989
90	MP0003718_maternal_effect	0.84039199
91	MP0001819_abnormal_immune_cell	0.82681384
92	MP0003436_decreased_susceptibility_to	0.82552831
93	MP0003866_abnormal_defecation	0.82337589
94	MP0010368_abnormal_lymphatic_system	0.80806989
95	MP0000372_irregular_coat_pigmentation	0.80593349
96	MP0003183_abnormal_peptide_metabolism	0.80589638
97	MP0002420_abnormal_adaptive_immunity	0.79741125
98	MP0002972_abnormal_cardiac_muscle	0.77276446
99	MP0003638_abnormal_response/metabolism_	0.75530402
100	MP0000750_abnormal_muscle_regeneration	0.73058190

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Limb dystonia (HP:0002451)	4.57303924
2	Decreased circulating renin level (HP:0003351)	4.11064308
3	Tongue fasciculations (HP:0001308)	4.04174429
4	Renal cortical cysts (HP:0000803)	3.73156579
5	Lipid accumulation in hepatocytes (HP:0006561)	3.47595737
6	Muscle fibrillation (HP:0010546)	3.44610804
7	Congenital, generalized hypertrichosis (HP:0004540)	3.43770494
8	Abnormality of the renal cortex (HP:0011035)	3.32177490
9	Mitochondrial inheritance (HP:0001427)	3.20946737
10	Increased hepatocellular lipid droplets (HP:0006565)	3.14929734
11	Hepatic necrosis (HP:0002605)	3.12534977
12	Hepatocellular necrosis (HP:0001404)	3.10841331
13	Type II lissencephaly (HP:0007260)	3.02809306
14	Increased CSF lactate (HP:0002490)	2.96031628
15	IgG deficiency (HP:0004315)	2.82274464
16	Hypothermia (HP:0002045)	2.80821881
17	Hypokinesia (HP:0002375)	2.77867572
18	Abnormal drinking behavior (HP:0030082)	2.77283931
19	Polydipsia (HP:0001959)	2.77283931
20	Abnormality of renin-angiotensin system (HP:0000847)	2.67531761
21	Oral leukoplakia (HP:0002745)	2.65231423
22	Absent/shortened dynein arms (HP:0200106)	2.59527838
23	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.59527838
24	Renal Fanconi syndrome (HP:0001994)	2.52012712
25	Pancreatic cysts (HP:0001737)	2.50928137
26	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.49635984
27	Abnormality of alanine metabolism (HP:0010916)	2.49635984
28	Hyperalaninemia (HP:0003348)	2.49635984
29	Exertional dyspnea (HP:0002875)	2.48271216
30	Abnormality of urine glucose concentration (HP:0011016)	2.46013735
31	Glycosuria (HP:0003076)	2.46013735
32	Nephronophthisis (HP:0000090)	2.44399006
33	Fibular aplasia (HP:0002990)	2.43452636
34	Delayed gross motor development (HP:0002194)	2.41280894
35	Increased intramyocellular lipid droplets (HP:0012240)	2.39950869
36	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.39270726
37	Acute necrotizing encephalopathy (HP:0006965)	2.38880282
38	3-Methylglutaconic aciduria (HP:0003535)	2.37790865
39	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.37608865
40	Increased serum lactate (HP:0002151)	2.36734151
41	Molar tooth sign on MRI (HP:0002419)	2.34826829
42	Abnormality of midbrain morphology (HP:0002418)	2.34826829
43	Increased muscle lipid content (HP:0009058)	2.33277783
44	Congenital stationary night blindness (HP:0007642)	2.28458909
45	Stomatitis (HP:0010280)	2.27346024
46	Stomach cancer (HP:0012126)	2.23166231
47	Abnormality of the renal medulla (HP:0100957)	2.20286773
48	Pancreatic fibrosis (HP:0100732)	2.18998906
49	Palpitations (HP:0001962)	2.16801119
50	Abnormal mitochondria in muscle tissue (HP:0008316)	2.16713353
51	Delayed CNS myelination (HP:0002188)	2.15864624
52	Abnormal rod and cone electroretinograms (HP:0008323)	2.15143645
53	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.12530208
54	Aplasia/hypoplasia of the uterus (HP:0008684)	2.11964748
55	Pustule (HP:0200039)	2.11066359
56	Hypoplasia of the uterus (HP:0000013)	2.10041525
57	Lactic acidosis (HP:0003128)	2.09668351
58	Progressive macrocephaly (HP:0004481)	2.08538504
59	Polyuria (HP:0000103)	2.08466525
60	Dyskinesia (HP:0100660)	2.07442363
61	Abolished electroretinogram (ERG) (HP:0000550)	2.07105977
62	Short tibia (HP:0005736)	2.05582100
63	Late onset (HP:0003584)	2.05096369
64	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.04725716
65	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.04725716
66	Hypoplasia of the fovea (HP:0007750)	2.02111956
67	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.02111956
68	Anomalous pulmonary venous return (HP:0010772)	2.02054910
69	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.01474766
70	Severe muscular hypotonia (HP:0006829)	2.01448896
71	Acute encephalopathy (HP:0006846)	2.01438912
72	Metabolic alkalosis (HP:0200114)	2.00584020
73	Methylmalonic acidemia (HP:0002912)	1.97593531
74	Chronic hepatic failure (HP:0100626)	1.95200078
75	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.94792471
76	Abnormality of the fovea (HP:0000493)	1.92079534
77	Insulin-resistant diabetes mellitus (HP:0000831)	1.91356967
78	Alkalosis (HP:0001948)	1.90144032
79	True hermaphroditism (HP:0010459)	1.89443070
80	Abnormality of the pons (HP:0007361)	1.88934398
81	Hypokalemic alkalosis (HP:0001949)	1.88124478
82	Large for gestational age (HP:0001520)	1.86823935
83	Elevated erythrocyte sedimentation rate (HP:0003565)	1.83253171
84	Abnormal urine output (HP:0012590)	1.83130836
85	Constricted visual fields (HP:0001133)	1.82513434
86	Methylmalonic aciduria (HP:0012120)	1.82467131
87	Syncope (HP:0001279)	1.81454821
88	Respiratory failure (HP:0002878)	1.78530200
89	Fair hair (HP:0002286)	1.77881686
90	Prostate neoplasm (HP:0100787)	1.76913489
91	Amelogenesis imperfecta (HP:0000705)	1.76644849
92	Medial flaring of the eyebrow (HP:0010747)	1.74967900
93	Abnormality of T cell physiology (HP:0011840)	1.73546846
94	Hypomagnesemia (HP:0002917)	1.72438158
95	Ketoacidosis (HP:0001993)	1.69733984
96	Abnormality of renal excretion (HP:0011036)	1.68403149
97	Abnormality of the prostate (HP:0008775)	1.68319335
98	Calf muscle hypertrophy (HP:0008981)	1.68145650
99	Clumsiness (HP:0002312)	1.67498750
100	Abnormality of the pulmonary veins (HP:0011718)	1.66765058

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	4.36534806
2	TAOK3	4.27280652
3	BLK	3.52844208
4	ZAK	3.11574574
5	FRK	2.87383593
6	MAP4K2	2.65195782
7	MAPKAPK5	2.39717040
8	MST4	2.38215729
9	PHKG2	2.33369334
10	PHKG1	2.33369334
11	PINK1	2.25639515
12	TXK	2.14899262
13	ADRBK2	1.83975741
14	WNK4	1.82605128
15	MAPKAPK3	1.82069008
16	NUAK1	1.80015415
17	MAP3K12	1.74319605
18	CSNK1G3	1.70293846
19	BUB1	1.67092547
20	GRK5	1.61990923
21	BCKDK	1.58506875
22	BMPR1B	1.56393496
23	GRK1	1.54892149
24	MAP2K7	1.52698904
25	STK39	1.51042523
26	VRK2	1.49441404
27	GRK6	1.45664316
28	LIMK1	1.44603033
29	TESK2	1.40433941
30	CSNK1G2	1.40289260
31	CSNK1G1	1.39822566
32	MAP3K4	1.39540313
33	OXSR1	1.37485540
34	VRK1	1.27820497
35	CAMKK2	1.17412768
36	MYLK	1.15672388
37	DAPK2	1.14198752
38	MAP2K2	1.10359065
39	TRPM7	1.06040067
40	IKBKB	1.05095865
41	ACVR1B	0.97028509
42	OBSCN	0.94538054
43	RPS6KA5	0.93599823
44	SYK	0.91776624
45	BMPR2	0.90703591
46	IKBKE	0.87494548
47	EIF2AK2	0.87262581
48	PTK2B	0.87144721
49	GRK7	0.87077384
50	INSRR	0.86569050
51	WNK3	0.85646728
52	STK16	0.81355987
53	CAMK2D	0.78119524
54	DAPK1	0.76454335
55	TBK1	0.75151503
56	CSNK1A1L	0.75083562
57	SCYL2	0.74563666
58	TESK1	0.74023326
59	ERBB3	0.70036961
60	MAP3K14	0.67937728
61	TEC	0.66255860
62	ADRBK1	0.63949632
63	BRSK2	0.62302924
64	NEK1	0.59796817
65	MUSK	0.59493550
66	ITK	0.59252971
67	LMTK2	0.59049173
68	HIPK2	0.58487544
69	TIE1	0.58016963
70	CDK8	0.57817089
71	MAPK13	0.56604212
72	CAMK2A	0.55051780
73	PLK2	0.52245612
74	PRKCE	0.51942175
75	PAK3	0.51377323
76	EPHA3	0.49275392
77	FES	0.48673315
78	PIK3CA	0.48639518
79	PRKAA2	0.47424541
80	CAMK2G	0.47422170
81	MAP3K11	0.43548653
82	FER	0.39779931
83	EIF2AK3	0.39575457
84	WNK1	0.35736372
85	CAMK2B	0.35553957
86	LYN	0.35131570
87	MAP2K6	0.33869777
88	PIM1	0.33737553
89	IGF1R	0.33195278
90	ABL2	0.31869127
91	PRKCQ	0.31775268
92	TGFBR2	0.30658160
93	KDR	0.29537951
94	PDK2	0.28764852
95	PRKACA	0.28602851
96	MAPKAPK2	0.28550442
97	PRKCI	0.28133390
98	CSNK1A1	0.26766367
99	CHUK	0.26477255
100	PRKCA	0.26304901

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur metabolism_Homo sapiens_hsa00920	3.16520288
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.03754156
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.73720267
4	Parkinsons disease_Homo sapiens_hsa05012	2.72985194
5	Asthma_Homo sapiens_hsa05310	2.42143648
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.00706784
7	Proteasome_Homo sapiens_hsa03050	1.95540841
8	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.86636847
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.78144859
10	Allograft rejection_Homo sapiens_hsa05330	1.76344394
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.74329646
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.71504002
13	Salivary secretion_Homo sapiens_hsa04970	1.70332809
14	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.67739594
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.67442208
16	RNA polymerase_Homo sapiens_hsa03020	1.65784338
17	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.63847643
18	Collecting duct acid secretion_Homo sapiens_hsa04966	1.62887736
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.62193224
20	Graft-versus-host disease_Homo sapiens_hsa05332	1.60051787
21	Alzheimers disease_Homo sapiens_hsa05010	1.55744250
22	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.54497250
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.52806866
24	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.51194815
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.46994281
26	Huntingtons disease_Homo sapiens_hsa05016	1.43116534
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.42648349
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.40988022
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.38362509
30	Primary immunodeficiency_Homo sapiens_hsa05340	1.29059700
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.28789328
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.28448144
33	Regulation of autophagy_Homo sapiens_hsa04140	1.27228150
34	Rheumatoid arthritis_Homo sapiens_hsa05323	1.25890050
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.24574589
36	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.19639632
37	Protein export_Homo sapiens_hsa03060	1.16760459
38	Amphetamine addiction_Homo sapiens_hsa05031	1.14256543
39	Fatty acid elongation_Homo sapiens_hsa00062	1.13673937
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13576957
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13184899
42	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.11039501
43	Phototransduction_Homo sapiens_hsa04744	1.09407219
44	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.08483301
45	Insulin secretion_Homo sapiens_hsa04911	1.07632103
46	Homologous recombination_Homo sapiens_hsa03440	1.05792762
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.04970666
48	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.04813216
49	Peroxisome_Homo sapiens_hsa04146	1.04258923
50	RNA degradation_Homo sapiens_hsa03018	1.01104839
51	Caffeine metabolism_Homo sapiens_hsa00232	1.00348977
52	Circadian rhythm_Homo sapiens_hsa04710	0.98961226
53	Butanoate metabolism_Homo sapiens_hsa00650	0.97800652
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.97249572
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.94833576
56	Purine metabolism_Homo sapiens_hsa00230	0.94211393
57	Folate biosynthesis_Homo sapiens_hsa00790	0.93355763
58	Morphine addiction_Homo sapiens_hsa05032	0.90092539
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.89646094
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.89166718
61	Glutathione metabolism_Homo sapiens_hsa00480	0.87413289
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.86229798
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.84431823
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.81837524
65	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.81757297
66	Olfactory transduction_Homo sapiens_hsa04740	0.80520156
67	Cocaine addiction_Homo sapiens_hsa05030	0.79871061
68	Sulfur relay system_Homo sapiens_hsa04122	0.76919989
69	Pyrimidine metabolism_Homo sapiens_hsa00240	0.73059169
70	Basal transcription factors_Homo sapiens_hsa03022	0.70016378
71	Retinol metabolism_Homo sapiens_hsa00830	0.68033102
72	Mineral absorption_Homo sapiens_hsa04978	0.64985431
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.63923975
74	Antigen processing and presentation_Homo sapiens_hsa04612	0.63346797
75	Renin secretion_Homo sapiens_hsa04924	0.62049657
76	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.60342072
77	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.58461763
78	Metabolic pathways_Homo sapiens_hsa01100	0.58396832
79	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.58060210
80	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.58050718
81	Tyrosine metabolism_Homo sapiens_hsa00350	0.57618021
82	ABC transporters_Homo sapiens_hsa02010	0.54177204
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54106149
84	Circadian entrainment_Homo sapiens_hsa04713	0.53870363
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.53688521
86	Serotonergic synapse_Homo sapiens_hsa04726	0.53684191
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49644334
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49092716
89	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.48001907
90	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.47709705
91	Taste transduction_Homo sapiens_hsa04742	0.46665411
92	Fatty acid degradation_Homo sapiens_hsa00071	0.46102105
93	Alcoholism_Homo sapiens_hsa05034	0.45024251
94	Viral myocarditis_Homo sapiens_hsa05416	0.44632920
95	Nicotine addiction_Homo sapiens_hsa05033	0.44189774
96	Propanoate metabolism_Homo sapiens_hsa00640	0.43368054
97	Nucleotide excision repair_Homo sapiens_hsa03420	0.43008004
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.40025679
99	Vibrio cholerae infection_Homo sapiens_hsa05110	0.38127942
100	GABAergic synapse_Homo sapiens_hsa04727	0.36905680

MTRNR2L3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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