ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to Golgi (GO:0072600)	4.50571851
2	carnitine shuttle (GO:0006853)	4.12167987
3	protein targeting to Golgi (GO:0000042)	4.06550737
4	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	4.05682467
5	fatty acid transmembrane transport (GO:1902001)	3.95112300
6	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.79716820
7	regulation of relaxation of muscle (GO:1901077)	3.69325282
8	positive regulation of mitochondrial fission (GO:0090141)	3.67233041
9	flavonoid metabolic process (GO:0009812)	3.48005427
10	actin-myosin filament sliding (GO:0033275)	3.44163278
11	muscle filament sliding (GO:0030049)	3.44163278
12	actin-mediated cell contraction (GO:0070252)	3.36639560
13	sulfation (GO:0051923)	3.33495776
14	sleep (GO:0030431)	3.28965800
15	protein polyglutamylation (GO:0018095)	3.27116023
16	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.26448665
17	peroxisome fission (GO:0016559)	3.25614996
18	parturition (GO:0007567)	3.23894804
19	regulation of skeletal muscle contraction (GO:0014819)	3.10946663
20	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	3.10721941
21	cellular ketone body metabolic process (GO:0046950)	3.08976638
22	response to pheromone (GO:0019236)	3.08701776
23	protein localization to Golgi apparatus (GO:0034067)	3.08234959
24	carnitine transmembrane transport (GO:1902603)	3.04614547
25	skeletal muscle adaptation (GO:0043501)	3.03622820
26	sperm motility (GO:0030317)	3.03113909
27	coenzyme catabolic process (GO:0009109)	2.99971311
28	amino-acid betaine transport (GO:0015838)	2.98694868
29	carnitine transport (GO:0015879)	2.98694868
30	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.90712568
31	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.90712568
32	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.87102512
33	regulation of cell communication by electrical coupling (GO:0010649)	2.85558538
34	regulation of coenzyme metabolic process (GO:0051196)	2.84199216
35	regulation of cofactor metabolic process (GO:0051193)	2.84199216
36	intra-Golgi vesicle-mediated transport (GO:0006891)	2.82893158
37	negative regulation of protein localization to cell surface (GO:2000009)	2.81735623
38	positive regulation of glycolytic process (GO:0045821)	2.79880042
39	adenosine metabolic process (GO:0046085)	2.79649964
40	regulation of glycolytic process (GO:0006110)	2.77189171
41	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	2.74721675
42	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.66485930
43	sarcomere organization (GO:0045214)	2.65165332
44	regulation of endothelial cell differentiation (GO:0045601)	2.64142597
45	acrosome reaction (GO:0007340)	2.63865544
46	cyclic nucleotide catabolic process (GO:0009214)	2.63541157
47	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	2.62238340
48	ketone body metabolic process (GO:1902224)	2.57312737
49	cAMP catabolic process (GO:0006198)	2.55046081
50	male genitalia development (GO:0030539)	2.52051316
51	phenol-containing compound catabolic process (GO:0019336)	2.51823062
52	quinone biosynthetic process (GO:1901663)	2.50797393
53	seminiferous tubule development (GO:0072520)	2.50536315
54	DNA dealkylation (GO:0035510)	2.50065777
55	protein K48-linked deubiquitination (GO:0071108)	2.49455431
56	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.47518630
57	rRNA catabolic process (GO:0016075)	2.45841213
58	regulation of hippo signaling (GO:0035330)	2.45631187
59	positive regulation of endothelial cell differentiation (GO:0045603)	2.45533130
60	cardiac septum development (GO:0003279)	2.45532319
61	C4-dicarboxylate transport (GO:0015740)	2.44274148
62	DNA integration (GO:0015074)	2.43448265
63	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.43398683
64	replicative senescence (GO:0090399)	2.43267327
65	cGMP-mediated signaling (GO:0019934)	2.42756327
66	regulation of mitochondrial fission (GO:0090140)	2.42664471
67	regulation of energy homeostasis (GO:2000505)	2.40908116
68	lipoprotein transport (GO:0042953)	2.39739074
69	regulation of cardioblast proliferation (GO:0003264)	2.37922308
70	regulation of secondary heart field cardioblast proliferation (GO:0003266)	2.37922308
71	striated muscle atrophy (GO:0014891)	2.37850547
72	midgut development (GO:0007494)	2.37717092
73	regulation of guanylate cyclase activity (GO:0031282)	2.36799972
74	pyrimidine dimer repair (GO:0006290)	2.35796607
75	myofibril assembly (GO:0030239)	2.34076303
76	positive regulation of guanylate cyclase activity (GO:0031284)	2.33885027
77	ubiquinone biosynthetic process (GO:0006744)	2.33859193
78	nucleoside bisphosphate metabolic process (GO:0033865)	2.33056613
79	purine nucleoside bisphosphate metabolic process (GO:0034032)	2.33056613
80	ribonucleoside bisphosphate metabolic process (GO:0033875)	2.33056613
81	actin filament-based movement (GO:0030048)	2.31173757
82	microtubule depolymerization (GO:0007019)	2.30593592
83	regulation of cilium movement (GO:0003352)	2.30525588
84	angiotensin maturation (GO:0002003)	2.29917677
85	ubiquinone metabolic process (GO:0006743)	2.29614253
86	behavioral response to nicotine (GO:0035095)	2.29391635
87	protein K63-linked deubiquitination (GO:0070536)	2.27379683
88	cardiac muscle cell development (GO:0055013)	2.27300812
89	ventricular septum development (GO:0003281)	2.26743227
90	regulation of hexokinase activity (GO:1903299)	2.25542665
91	regulation of glucokinase activity (GO:0033131)	2.25542665
92	negative regulation of mast cell activation (GO:0033004)	2.25501001
93	intestinal absorption (GO:0050892)	2.25409692
94	regulation of sarcomere organization (GO:0060297)	2.25214754
95	neurotransmitter biosynthetic process (GO:0042136)	2.23937004
96	regulation of sulfur metabolic process (GO:0042762)	2.23490945
97	magnesium ion transport (GO:0015693)	2.23059257
98	cellular glucuronidation (GO:0052695)	2.22404069
99	antibacterial humoral response (GO:0019731)	2.21881008
100	DNA demethylation (GO:0080111)	2.21537423

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.38529103
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.21108114
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.03482577
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.96023937
5	TAF15_26573619_Chip-Seq_HEK293_Human	2.75011906
6	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.63028089
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.45738496
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.40632143
9	FUS_26573619_Chip-Seq_HEK293_Human	2.39029981
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.34659945
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.26342282
12	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.25748351
13	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.22728081
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.16516524
15	IRF1_19129219_ChIP-ChIP_H3396_Human	2.15910906
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.07053816
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.05401776
18	P300_19829295_ChIP-Seq_ESCs_Human	2.03853919
19	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.03300131
20	VDR_22108803_ChIP-Seq_LS180_Human	2.01860434
21	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.00565804
22	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.84253336
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.80044197
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.73538756
25	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.69272235
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.67572050
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66148511
28	STAT3_23295773_ChIP-Seq_U87_Human	1.64692379
29	EWS_26573619_Chip-Seq_HEK293_Human	1.62073319
30	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.60126798
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59253285
32	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55589968
33	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.54988039
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.54458207
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54458207
36	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.49131545
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.42747192
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42613916
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.41700935
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.39473759
41	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38557917
42	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.36716451
43	AR_25329375_ChIP-Seq_VCAP_Human	1.34497325
44	TCF4_23295773_ChIP-Seq_U87_Human	1.32445434
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31311435
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.29043273
47	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28979343
48	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28632690
49	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.24628689
50	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.23691665
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.22955432
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21491917
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21491917
54	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.16371828
55	CDX2_22108803_ChIP-Seq_LS180_Human	1.15143400
56	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11133472
57	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.10861668
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10706471
59	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.10350950
60	TP53_18474530_ChIP-ChIP_U2OS_Human	1.09683735
61	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.09619327
62	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.09445672
63	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09066286
64	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.08699120
65	TBL1_22424771_ChIP-Seq_293T_Human	1.08448601
66	AR_21572438_ChIP-Seq_LNCaP_Human	1.07361825
67	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07341521
68	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.06889947
69	TP53_22573176_ChIP-Seq_HFKS_Human	1.06556933
70	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06422119
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05996990
72	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04362543
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.04143647
74	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.02972436
75	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.02677457
76	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.02677457
77	MYC_18940864_ChIP-ChIP_HL60_Human	1.02656939
78	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.02624758
79	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.01803411
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01787158
81	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01161310
82	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.00938043
83	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.99528630
84	AR_20517297_ChIP-Seq_VCAP_Human	0.99456036
85	NFYB_21822215_ChIP-Seq_K562_Human	0.99183348
86	BCAT_22108803_ChIP-Seq_LS180_Human	0.97567445
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97557649
88	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.97516320
89	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.96928234
90	P53_22387025_ChIP-Seq_ESCs_Mouse	0.96472988
91	CJUN_26792858_Chip-Seq_BT549_Human	0.96056309
92	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.95147601
93	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95119729
94	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.94296715
95	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.94101442
96	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.93239832
97	AHR_22903824_ChIP-Seq_MCF-7_Human	0.93182984
98	ERG_20517297_ChIP-Seq_VCAP_Human	0.92779043
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92772281
100	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.91643459

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	5.03666179
2	MP0002009_preneoplasia	3.49271397
3	MP0004147_increased_porphyrin_level	2.66911975
4	MP0002822_catalepsy	2.57785776
5	MP0004145_abnormal_muscle_electrophysio	2.56536480
6	MP0005085_abnormal_gallbladder_physiolo	2.55427983
7	MP0009697_abnormal_copulation	2.43080502
8	MP0002102_abnormal_ear_morphology	2.38562262
9	MP0005187_abnormal_penis_morphology	2.35076457
10	MP0005360_urolithiasis	2.34849449
11	MP0004036_abnormal_muscle_relaxation	2.30902959
12	MP0005670_abnormal_white_adipose	2.24030213
13	MP0001661_extended_life_span	2.22978556
14	MP0004084_abnormal_cardiac_muscle	2.18155582
15	MP0000751_myopathy	2.12102765
16	MP0004215_abnormal_myocardial_fiber	2.07583252
17	MP0000749_muscle_degeneration	2.01124595
18	MP0006072_abnormal_retinal_apoptosis	1.94789931
19	MP0004043_abnormal_pH_regulation	1.91680888
20	MP0001529_abnormal_vocalization	1.91073541
21	MP0000013_abnormal_adipose_tissue	1.89838397
22	MP0004130_abnormal_muscle_cell	1.89065684
23	MP0002876_abnormal_thyroid_physiology	1.89011194
24	MP0002837_dystrophic_cardiac_calcinosis	1.87495248
25	MP0005410_abnormal_fertilization	1.78043952
26	MP0004484_altered_response_of	1.74498476
27	MP0008775_abnormal_heart_ventricle	1.68892674
28	MP0005620_abnormal_muscle_contractility	1.64310775
29	MP0010329_abnormal_lipoprotein_level	1.58738117
30	MP0005253_abnormal_eye_physiology	1.56974384
31	MP0003718_maternal_effect	1.55758639
32	MP0002106_abnormal_muscle_physiology	1.55525574
33	MP0003137_abnormal_impulse_conducting	1.50236151
34	MP0001984_abnormal_olfaction	1.45783865
35	MP0005365_abnormal_bile_salt	1.45560788
36	MP0005646_abnormal_pituitary_gland	1.42987621
37	MP0001666_abnormal_nutrient_absorption	1.42312023
38	MP0000465_gastrointestinal_hemorrhage	1.39747306
39	MP0006276_abnormal_autonomic_nervous	1.38053283
40	MP0005332_abnormal_amino_acid	1.33640850
41	MP0000750_abnormal_muscle_regeneration	1.27399696
42	MP0002972_abnormal_cardiac_muscle	1.26874931
43	MP0005645_abnormal_hypothalamus_physiol	1.19809612
44	MP0005083_abnormal_biliary_tract	1.19092574
45	MP0002234_abnormal_pharynx_morphology	1.15748587
46	MP0005551_abnormal_eye_electrophysiolog	1.14789981
47	MP0004085_abnormal_heartbeat	1.13449576
48	MP0005369_muscle_phenotype	1.13448912
49	MP0000569_abnormal_digit_pigmentation	1.13147074
50	MP0002332_abnormal_exercise_endurance	1.11915915
51	MP0003315_abnormal_perineum_morphology	1.11601022
52	MP0002638_abnormal_pupillary_reflex	1.11079062
53	MP0000538_abnormal_urinary_bladder	1.09619459
54	MP0003183_abnormal_peptide_metabolism	1.07549364
55	MP0004087_abnormal_muscle_fiber	1.06956870
56	MP0004233_abnormal_muscle_weight	1.04478093
57	MP0002127_abnormal_cardiovascular_syste	1.03494675
58	MP0002269_muscular_atrophy	1.02561703
59	MP0000230_abnormal_systemic_arterial	1.01386611
60	MP0001486_abnormal_startle_reflex	1.00384947
61	MP0001879_abnormal_lymphatic_vessel	0.99130708
62	MP0001299_abnormal_eye_distance/	0.96431989
63	MP0005167_abnormal_blood-brain_barrier	0.96148603
64	MP0005266_abnormal_metabolism	0.95459125
65	MP0000747_muscle_weakness	0.94041732
66	MP0001764_abnormal_homeostasis	0.92901428
67	MP0002736_abnormal_nociception_after	0.92899371
68	MP0004924_abnormal_behavior	0.92558514
69	MP0005386_behavior/neurological_phenoty	0.92558514
70	MP0003252_abnormal_bile_duct	0.90853637
71	MP0010352_gastrointestinal_tract_polyps	0.90521353
72	MP0006138_congestive_heart_failure	0.90377776
73	MP0008872_abnormal_physiological_respon	0.89822853
74	MP0000759_abnormal_skeletal_muscle	0.88322379
75	MP0001664_abnormal_digestion	0.84964186
76	MP0003698_abnormal_male_reproductive	0.84740416
77	MP0003879_abnormal_hair_cell	0.84490884
78	MP0009046_muscle_twitch	0.84245717
79	MP0002166_altered_tumor_susceptibility	0.83510846
80	MP0001905_abnormal_dopamine_level	0.83356841
81	MP0005385_cardiovascular_system_phenoty	0.83302013
82	MP0001544_abnormal_cardiovascular_syste	0.83302013
83	MP0002160_abnormal_reproductive_system	0.83062601
84	MP0004272_abnormal_basement_membrane	0.82770164
85	MP0003221_abnormal_cardiomyocyte_apopto	0.82631532
86	MP0003937_abnormal_limbs/digits/tail_de	0.81963057
87	MP0000427_abnormal_hair_cycle	0.81720013
88	MP0006036_abnormal_mitochondrial_physio	0.79400347
89	MP0000733_abnormal_muscle_development	0.77755082
90	MP0009384_cardiac_valve_regurgitation	0.76474407
91	MP0005330_cardiomyopathy	0.75856451
92	MP0002971_abnormal_brown_adipose	0.75851032
93	MP0003950_abnormal_plasma_membrane	0.75751149
94	MP0001929_abnormal_gametogenesis	0.73341149
95	MP0002557_abnormal_social/conspecific_i	0.71518159
96	MP0009840_abnormal_foam_cell	0.71050060
97	MP0004134_abnormal_chest_morphology	0.70686686
98	MP0005389_reproductive_system_phenotype	0.70425981
99	MP0004142_abnormal_muscle_tone	0.70039059
100	MP0000631_abnormal_neuroendocrine_gland	0.69856377

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Nemaline bodies (HP:0003798)	4.21336505
2	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	4.17331825
3	Muscle fiber inclusion bodies (HP:0100299)	4.16579386
4	Renal cortical cysts (HP:0000803)	3.90094823
5	Exercise-induced muscle cramps (HP:0003710)	3.81020767
6	Myoglobinuria (HP:0002913)	3.47330903
7	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.33709977
8	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.32398540
9	Short tibia (HP:0005736)	3.06540303
10	Abnormality of the renal cortex (HP:0011035)	3.05154354
11	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.88060222
12	Abnormality of alanine metabolism (HP:0010916)	2.88060222
13	Hyperalaninemia (HP:0003348)	2.88060222
14	Calf muscle hypertrophy (HP:0008981)	2.81232874
15	Cerebellar dysplasia (HP:0007033)	2.80647481
16	Muscle hypertrophy of the lower extremities (HP:0008968)	2.72928514
17	Bundle branch block (HP:0011710)	2.70906798
18	Acanthocytosis (HP:0001927)	2.70745052
19	Rimmed vacuoles (HP:0003805)	2.68389011
20	Decreased circulating renin level (HP:0003351)	2.66892120
21	Rhabdomyolysis (HP:0003201)	2.58411320
22	Chronic hepatic failure (HP:0100626)	2.57831206
23	Exercise-induced myalgia (HP:0003738)	2.56606388
24	Asymmetric septal hypertrophy (HP:0001670)	2.51513552
25	Pancreatic cysts (HP:0001737)	2.43530056
26	Tubulointerstitial nephritis (HP:0001970)	2.33337538
27	Fibular aplasia (HP:0002990)	2.31405539
28	Abnormality of the calf musculature (HP:0001430)	2.30662544
29	Hyperglycinuria (HP:0003108)	2.26342579
30	Medial flaring of the eyebrow (HP:0010747)	2.19877669
31	Increased purine levels (HP:0004368)	2.18090801
32	Hyperuricemia (HP:0002149)	2.18090801
33	Hyperkalemia (HP:0002153)	2.15049795
34	Abnormality of proline metabolism (HP:0010907)	2.13688698
35	Hydroxyprolinuria (HP:0003080)	2.13688698
36	Pancreatic fibrosis (HP:0100732)	2.12256553
37	Hypoalphalipoproteinemia (HP:0003233)	2.08644645
38	Abnormality of the ischium (HP:0003174)	2.08618268
39	Distal arthrogryposis (HP:0005684)	2.07171062
40	Insulin-resistant diabetes mellitus (HP:0000831)	2.03933604
41	Congenital primary aphakia (HP:0007707)	2.01881490
42	Hypolipoproteinemia (HP:0010981)	2.01468445
43	Abnormality of serine family amino acid metabolism (HP:0010894)	1.99716411
44	Abnormality of glycine metabolism (HP:0010895)	1.99716411
45	Nephronophthisis (HP:0000090)	1.98903045
46	Long clavicles (HP:0000890)	1.94691376
47	Short 1st metacarpal (HP:0010034)	1.92734257
48	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.92734257
49	Abnormality of urine glucose concentration (HP:0011016)	1.92404792
50	Glycosuria (HP:0003076)	1.92404792
51	Gait imbalance (HP:0002141)	1.91931460
52	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.91082701
53	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.90768470
54	Hyperventilation (HP:0002883)	1.89947954
55	Type 1 muscle fiber predominance (HP:0003803)	1.88835756
56	Abnormality of potassium homeostasis (HP:0011042)	1.87593438
57	Inability to walk (HP:0002540)	1.83670341
58	Abnormal finger flexion creases (HP:0006143)	1.82570915
59	Genital tract atresia (HP:0001827)	1.82216322
60	Frequent falls (HP:0002359)	1.81053542
61	Abnormality of purine metabolism (HP:0004352)	1.80406485
62	Abnormality of the 1st metacarpal (HP:0010009)	1.79098430
63	Type II lissencephaly (HP:0007260)	1.78768635
64	Short phalanx of the thumb (HP:0009660)	1.77583941
65	Colon cancer (HP:0003003)	1.77229465
66	Abnormal albumin level (HP:0012116)	1.76580882
67	Hypoalbuminemia (HP:0003073)	1.76580882
68	Abnormality of vitamin B metabolism (HP:0004340)	1.76541551
69	Nephrogenic diabetes insipidus (HP:0009806)	1.76145407
70	Hyperammonemia (HP:0001987)	1.75568943
71	Vaginal atresia (HP:0000148)	1.75254131
72	Hypokalemia (HP:0002900)	1.73528749
73	Hepatic necrosis (HP:0002605)	1.72624741
74	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.71414112
75	Impulsivity (HP:0100710)	1.71125190
76	Sudden death (HP:0001699)	1.70962815
77	Proximal tubulopathy (HP:0000114)	1.70814902
78	Abnormality of serum amino acid levels (HP:0003112)	1.70718888
79	Alkalosis (HP:0001948)	1.68799722
80	Drooling (HP:0002307)	1.68066649
81	Left ventricular hypertrophy (HP:0001712)	1.66671231
82	Absent phalangeal crease (HP:0006109)	1.66405025
83	EMG: myopathic abnormalities (HP:0003458)	1.65544138
84	Abnormality of midbrain morphology (HP:0002418)	1.65212098
85	Molar tooth sign on MRI (HP:0002419)	1.65212098
86	Chronic diarrhea (HP:0002028)	1.64064865
87	Abnormality of macular pigmentation (HP:0008002)	1.63590516
88	Abnormality of the renal medulla (HP:0100957)	1.63405506
89	Abnormal protein glycosylation (HP:0012346)	1.62886198
90	Abnormal glycosylation (HP:0012345)	1.62886198
91	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.62886198
92	Abnormal protein N-linked glycosylation (HP:0012347)	1.62886198
93	True hermaphroditism (HP:0010459)	1.62874534
94	Areflexia of lower limbs (HP:0002522)	1.62868373
95	Cerebral edema (HP:0002181)	1.61998175
96	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.60938635
97	Poor coordination (HP:0002370)	1.59062522
98	Ventricular tachycardia (HP:0004756)	1.58955945
99	Metabolic acidosis (HP:0001942)	1.58890788
100	Chorioretinal atrophy (HP:0000533)	1.58663619

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	OBSCN	3.95169556
2	AKT3	3.51604605
3	ZAK	3.37854577
4	ACVR1B	2.89861394
5	TLK1	2.89555919
6	MAP4K2	2.86929458
7	MAP3K4	2.83217140
8	TAOK3	2.82942893
9	EPHA3	2.67250680
10	MAP2K7	2.65410435
11	FRK	2.46549822
12	PHKG2	1.76318382
13	PHKG1	1.76318382
14	PLK4	1.70829945
15	PIK3CG	1.70219616
16	BMPR1B	1.68682615
17	SRPK1	1.65888610
18	PINK1	1.64099717
19	CSNK1A1L	1.62750198
20	STK39	1.56102814
21	INSRR	1.55569324
22	FLT3	1.55134324
23	CSNK1G3	1.49044576
24	CSNK1G1	1.41897798
25	PKN2	1.41004281
26	ERBB3	1.37761260
27	MYLK	1.32613990
28	BCKDK	1.19311573
29	RPS6KA5	1.17759326
30	CSNK1G2	1.16224673
31	MAP2K4	1.14062932
32	FER	1.13049227
33	SCYL2	1.11258364
34	PRKAA2	1.07499022
35	GRK1	1.07262983
36	NEK1	1.04181517
37	PDK2	1.03813889
38	CDK19	1.03417840
39	TESK2	1.02222146
40	BCR	1.02032230
41	WNK3	0.97207374
42	PRKAA1	0.96655513
43	LIMK1	0.95847638
44	CAMKK2	0.94652457
45	NUAK1	0.93283447
46	VRK1	0.92890383
47	MAPK13	0.92862946
48	BRSK2	0.92437522
49	OXSR1	0.91870565
50	MAP3K6	0.83156154
51	MUSK	0.82633842
52	CASK	0.81921036
53	ADRBK2	0.79830750
54	MAPKAPK3	0.75914443
55	NEK9	0.73463260
56	PLK2	0.73210013
57	NLK	0.71477834
58	MAPKAPK5	0.71324987
59	PAK3	0.70115934
60	STK38L	0.69388117
61	BUB1	0.68545787
62	TTN	0.64767908
63	BRD4	0.63642983
64	PIK3CA	0.63022558
65	TESK1	0.61738734
66	LMTK2	0.60462004
67	WNK4	0.59835695
68	MAPK11	0.59738257
69	PAK6	0.57384922
70	STK38	0.56934893
71	CAMK4	0.55780122
72	PAK2	0.54024063
73	MAP3K7	0.53199209
74	MAP2K2	0.52479987
75	PRKCE	0.51050247
76	PBK	0.50310192
77	TEC	0.49673934
78	PIM1	0.49233505
79	CAMK2A	0.48203186
80	PKN1	0.46945316
81	GRK6	0.46503806
82	CDK6	0.45852163
83	ADRBK1	0.43554294
84	CCNB1	0.42196219
85	MARK1	0.41280959
86	PRKACA	0.40471308
87	AURKB	0.40146412
88	CAMK2D	0.38990003
89	DYRK1B	0.37344947
90	CHEK2	0.37058349
91	TXK	0.36783364
92	CAMK2G	0.36341437
93	PRKG1	0.34835429
94	SGK223	0.34443302
95	SGK494	0.34443302
96	PRKACG	0.34342757
97	PRKACB	0.34166875
98	AURKA	0.33999711
99	MET	0.33944013
100	SGK2	0.33606444

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	3.09951604
2	Alcoholism_Homo sapiens_hsa05034	2.71631141
3	Fat digestion and absorption_Homo sapiens_hsa04975	2.66734581
4	Sulfur metabolism_Homo sapiens_hsa00920	2.39523744
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.29833186
6	Renin-angiotensin system_Homo sapiens_hsa04614	2.11932301
7	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.06130229
8	Caffeine metabolism_Homo sapiens_hsa00232	2.02154299
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.00036921
10	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.97143036
11	Propanoate metabolism_Homo sapiens_hsa00640	1.82164728
12	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.77015911
13	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.75199519
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.73639889
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.73374408
16	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.62322429
17	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.60989265
18	Arginine biosynthesis_Homo sapiens_hsa00220	1.60607200
19	Fatty acid metabolism_Homo sapiens_hsa01212	1.58459782
20	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.58359043
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.54633763
22	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.50795295
23	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.48208067
24	Butanoate metabolism_Homo sapiens_hsa00650	1.45837376
25	Protein digestion and absorption_Homo sapiens_hsa04974	1.42139132
26	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.41543873
27	PPAR signaling pathway_Homo sapiens_hsa03320	1.39982711
28	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.38681118
29	Peroxisome_Homo sapiens_hsa04146	1.37560983
30	Fatty acid elongation_Homo sapiens_hsa00062	1.36291745
31	Fatty acid degradation_Homo sapiens_hsa00071	1.35945690
32	Circadian rhythm_Homo sapiens_hsa04710	1.35732240
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.32998805
34	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.31103104
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.29056630
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.24767770
37	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.21932919
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.21036222
39	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.15992985
40	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.13037313
41	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.11960911
42	ABC transporters_Homo sapiens_hsa02010	1.10711037
43	Sulfur relay system_Homo sapiens_hsa04122	1.10483666
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.09928545
45	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.07154831
46	Oxidative phosphorylation_Homo sapiens_hsa00190	1.06561332
47	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.00929053
48	Parkinsons disease_Homo sapiens_hsa05012	1.00831185
49	Retinol metabolism_Homo sapiens_hsa00830	1.00082289
50	Arginine and proline metabolism_Homo sapiens_hsa00330	0.99718727
51	Fanconi anemia pathway_Homo sapiens_hsa03460	0.94708772
52	Glycerolipid metabolism_Homo sapiens_hsa00561	0.94319177
53	Phenylalanine metabolism_Homo sapiens_hsa00360	0.93581368
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.93163918
55	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.91187784
56	Selenocompound metabolism_Homo sapiens_hsa00450	0.86828530
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.82626266
58	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.82288246
59	Galactose metabolism_Homo sapiens_hsa00052	0.82279499
60	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.82044403
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.80180846
62	Mineral absorption_Homo sapiens_hsa04978	0.80066952
63	Regulation of autophagy_Homo sapiens_hsa04140	0.79208743
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.76155031
65	Taste transduction_Homo sapiens_hsa04742	0.75148754
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.74623520
67	Ether lipid metabolism_Homo sapiens_hsa00565	0.72705283
68	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.72164090
69	Alzheimers disease_Homo sapiens_hsa05010	0.70184216
70	Non-homologous end-joining_Homo sapiens_hsa03450	0.68115478
71	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.68109674
72	Metabolic pathways_Homo sapiens_hsa01100	0.67936919
73	Purine metabolism_Homo sapiens_hsa00230	0.67383457
74	Huntingtons disease_Homo sapiens_hsa05016	0.66328297
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.65985239
76	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.65880049
77	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.65538505
78	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.65464003
79	Pyruvate metabolism_Homo sapiens_hsa00620	0.65087825
80	Nicotine addiction_Homo sapiens_hsa05033	0.62156740
81	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.61123636
82	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.60930106
83	Olfactory transduction_Homo sapiens_hsa04740	0.59410229
84	Carbon metabolism_Homo sapiens_hsa01200	0.58974332
85	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.56468390
86	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.54895161
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.54420394
88	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.53785058
89	Viral carcinogenesis_Homo sapiens_hsa05203	0.53211443
90	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.52626424
91	Morphine addiction_Homo sapiens_hsa05032	0.50806356
92	GABAergic synapse_Homo sapiens_hsa04727	0.50561565
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.49565201
94	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48728110
95	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.47717892
96	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.45980484
97	Bile secretion_Homo sapiens_hsa04976	0.45881547
98	Salivary secretion_Homo sapiens_hsa04970	0.43921545
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.43072917
100	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.42493072

MTRNR2L4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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