ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	6.25869378
2	behavioral response to nicotine (GO:0035095)	6.11638816
3	nonmotile primary cilium assembly (GO:0035058)	3.91559649
4	preassembly of GPI anchor in ER membrane (GO:0016254)	3.89111643
5	regulation of cilium movement (GO:0003352)	3.59775842
6	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	3.49129513
7	synaptic transmission, cholinergic (GO:0007271)	3.43850502
8	protein polyglutamylation (GO:0018095)	3.39905370
9	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.39363180
10	cell proliferation in forebrain (GO:0021846)	3.37629480
11	negative regulation of telomere maintenance (GO:0032205)	3.35866429
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.27092627
13	positive regulation of sodium ion transmembrane transport (GO:1902307)	3.25518460
14	protein localization to cilium (GO:0061512)	3.23767479
15	pyrimidine nucleobase catabolic process (GO:0006208)	3.17277271
16	detection of light stimulus involved in sensory perception (GO:0050962)	3.15190406
17	detection of light stimulus involved in visual perception (GO:0050908)	3.15190406
18	sperm motility (GO:0030317)	3.13760914
19	DNA deamination (GO:0045006)	3.13517042
20	neuronal action potential (GO:0019228)	3.07537980
21	negative regulation of response to food (GO:0032096)	2.99754034
22	negative regulation of appetite (GO:0032099)	2.99754034
23	auditory receptor cell differentiation (GO:0042491)	2.99662251
24	ATP synthesis coupled proton transport (GO:0015986)	2.98905342
25	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.98905342
26	mitochondrial calcium ion transport (GO:0006851)	2.97985968
27	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.96560829
28	regulation of female receptivity (GO:0045924)	2.95683488
29	neuronal action potential propagation (GO:0019227)	2.95535724
30	membrane depolarization during action potential (GO:0086010)	2.94982138
31	somite development (GO:0061053)	2.94576172
32	kynurenine metabolic process (GO:0070189)	2.92454643
33	negative regulation of mast cell activation (GO:0033004)	2.91648594
34	oxygen transport (GO:0015671)	2.90699424
35	indolalkylamine metabolic process (GO:0006586)	2.89931489
36	DNA methylation involved in gamete generation (GO:0043046)	2.89651923
37	regulation of microtubule-based movement (GO:0060632)	2.89380662
38	negative regulation of protein localization to cell surface (GO:2000009)	2.89305719
39	platelet dense granule organization (GO:0060155)	2.89211820
40	negative regulation of heart rate (GO:0010459)	2.87250625
41	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.87010714
42	calcium ion import (GO:0070509)	2.85306331
43	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.85013462
44	water-soluble vitamin biosynthetic process (GO:0042364)	2.84678338
45	epithelial cilium movement (GO:0003351)	2.80134927
46	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.77834783
47	positive regulation of cAMP-mediated signaling (GO:0043950)	2.77402848
48	parturition (GO:0007567)	2.75174331
49	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.72625776
50	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.72625776
51	NADH dehydrogenase complex assembly (GO:0010257)	2.72625776
52	amine catabolic process (GO:0009310)	2.70590021
53	cellular biogenic amine catabolic process (GO:0042402)	2.70590021
54	GPI anchor metabolic process (GO:0006505)	2.69850758
55	transmission of nerve impulse (GO:0019226)	2.69687955
56	cellular biogenic amine biosynthetic process (GO:0042401)	2.66712569
57	nucleobase catabolic process (GO:0046113)	2.65961190
58	intraciliary transport (GO:0042073)	2.64992105
59	response to pheromone (GO:0019236)	2.64838960
60	negative regulation of systemic arterial blood pressure (GO:0003085)	2.58846034
61	lipoxygenase pathway (GO:0019372)	2.58799382
62	snRNA transcription (GO:0009301)	2.57905029
63	tachykinin receptor signaling pathway (GO:0007217)	2.56014999
64	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.55582487
65	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.55228707
66	multicellular organism reproduction (GO:0032504)	2.54148869
67	axoneme assembly (GO:0035082)	2.53751438
68	calcium ion-dependent exocytosis (GO:0017156)	2.52868918
69	gamma-aminobutyric acid transport (GO:0015812)	2.51714237
70	regulation of action potential (GO:0098900)	2.48046559
71	amine biosynthetic process (GO:0009309)	2.47324926
72	cilium organization (GO:0044782)	2.47272569
73	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.45831358
74	protein complex biogenesis (GO:0070271)	2.45670784
75	cilium assembly (GO:0042384)	2.45013753
76	male meiosis I (GO:0007141)	2.44280235
77	tryptophan catabolic process (GO:0006569)	2.42431894
78	indole-containing compound catabolic process (GO:0042436)	2.42431894
79	indolalkylamine catabolic process (GO:0046218)	2.42431894
80	sulfation (GO:0051923)	2.41692053
81	substrate-independent telencephalic tangential migration (GO:0021826)	2.41029876
82	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.41029876
83	C-terminal protein lipidation (GO:0006501)	2.40227450
84	cilium movement (GO:0003341)	2.39961468
85	head development (GO:0060322)	2.38649526
86	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.38022377
87	piRNA metabolic process (GO:0034587)	2.36503814
88	sleep (GO:0030431)	2.35247149
89	chaperone-mediated protein transport (GO:0072321)	2.35149606
90	adaptation of signaling pathway (GO:0023058)	2.31400257
91	glycosphingolipid biosynthetic process (GO:0006688)	2.30148358
92	endoderm formation (GO:0001706)	2.29701513
93	primary amino compound metabolic process (GO:1901160)	2.26048415
94	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.25943879
95	establishment of protein localization to Golgi (GO:0072600)	2.25704685
96	female mating behavior (GO:0060180)	2.25438116
97	C-terminal protein amino acid modification (GO:0018410)	2.25378843
98	gas transport (GO:0015669)	2.24842652
99	cellular ketone body metabolic process (GO:0046950)	2.22705788
100	mitochondrial calcium ion homeostasis (GO:0051560)	2.21732023

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.66879778
2	ZNF274_21170338_ChIP-Seq_K562_Hela	2.89496423
3	VDR_22108803_ChIP-Seq_LS180_Human	2.75928159
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.74749607
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.58213810
6	IRF1_19129219_ChIP-ChIP_H3396_Human	2.55986518
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.25615518
8	IGF1R_20145208_ChIP-Seq_DFB_Human	1.95720956
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.93418638
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.93120531
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.88850282
12	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.85659948
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.84865077
14	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.82592967
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.82541631
16	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.75059659
17	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.74108736
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.73521426
19	RNF2_27304074_Chip-Seq_NSC_Mouse	1.72384739
20	REST_21632747_ChIP-Seq_MESCs_Mouse	1.71957212
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.71582194
22	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.69028384
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.67887294
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.58895019
25	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.58154078
26	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.56216935
27	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.48886664
28	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.48334780
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.48148892
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46385366
31	EWS_26573619_Chip-Seq_HEK293_Human	1.46242380
32	P300_19829295_ChIP-Seq_ESCs_Human	1.45534169
33	AR_21572438_ChIP-Seq_LNCaP_Human	1.44681452
34	TAF15_26573619_Chip-Seq_HEK293_Human	1.44343377
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.43340633
36	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.40479262
37	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.39375309
38	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.36548466
39	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.35339615
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.34684210
41	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.33460312
42	AR_25329375_ChIP-Seq_VCAP_Human	1.33448857
43	TCF4_23295773_ChIP-Seq_U87_Human	1.32165968
44	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.31763932
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.31699639
46	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.30689829
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.30173050
48	FUS_26573619_Chip-Seq_HEK293_Human	1.29550589
49	DROSHA_22980978_ChIP-Seq_HELA_Human	1.28422992
50	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.28072719
51	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.27847849
52	STAT3_23295773_ChIP-Seq_U87_Human	1.26845537
53	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.24459191
54	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.24445157
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.24198244
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.23329007
57	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.21505855
58	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.20137453
59	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.19746458
60	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.17010809
61	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.16600004
62	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.15924879
63	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.15924879
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15628175
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15628175
66	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.12999049
67	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.10529135
68	BCAT_22108803_ChIP-Seq_LS180_Human	1.10526888
69	ERA_21632823_ChIP-Seq_H3396_Human	1.08850418
70	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.08792404
71	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.08610921
72	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.08266671
73	CBP_20019798_ChIP-Seq_JUKART_Human	1.08266671
74	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.06769601
75	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.06068210
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.05982203
77	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.05673495
78	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.05257054
79	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04969319
80	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.04969319
81	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03894663
82	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03172566
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03109079
84	RUNX2_22187159_ChIP-Seq_PCA_Human	1.02577230
85	AR_20517297_ChIP-Seq_VCAP_Human	1.02180707
86	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.01674053
87	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01212529
88	NCOR_22424771_ChIP-Seq_293T_Human	1.00038917
89	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99928585
90	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.99665226
91	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.99145974
92	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.96906811
93	MYC_19829295_ChIP-Seq_ESCs_Human	0.94222854
94	HTT_18923047_ChIP-ChIP_STHdh_Human	0.94137494
95	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.93347976
96	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.93347976
97	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.92824488
98	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.92800423
99	OCT4_20526341_ChIP-Seq_ESCs_Human	0.92227578
100	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.91922539

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	3.23061261
2	MP0006276_abnormal_autonomic_nervous	2.56821531
3	MP0006292_abnormal_olfactory_placode	2.56811247
4	MP0004885_abnormal_endolymph	2.56223983
5	MP0002736_abnormal_nociception_after	2.52411017
6	MP0003879_abnormal_hair_cell	2.41235274
7	MP0001968_abnormal_touch/_nociception	2.23317129
8	MP0003011_delayed_dark_adaptation	2.21652170
9	MP0004145_abnormal_muscle_electrophysio	2.21061687
10	MP0005646_abnormal_pituitary_gland	2.20124974
11	MP0003880_abnormal_central_pattern	2.17188955
12	MP0004043_abnormal_pH_regulation	2.05015226
13	MP0008872_abnormal_physiological_respon	1.90595600
14	MP0005377_hearing/vestibular/ear_phenot	1.89552666
15	MP0003878_abnormal_ear_physiology	1.89552666
16	MP0005551_abnormal_eye_electrophysiolog	1.88936030
17	MP0004147_increased_porphyrin_level	1.87849476
18	MP0009046_muscle_twitch	1.86844695
19	MP0000372_irregular_coat_pigmentation	1.82542357
20	MP0002653_abnormal_ependyma_morphology	1.78082748
21	MP0003195_calcinosis	1.75864667
22	MP0002102_abnormal_ear_morphology	1.73384810
23	MP0002735_abnormal_chemical_nociception	1.73382640
24	MP0004142_abnormal_muscle_tone	1.69883005
25	MP0005083_abnormal_biliary_tract	1.68060716
26	MP0002272_abnormal_nervous_system	1.67808855
27	MP0009379_abnormal_foot_pigmentation	1.66941590
28	MP0001188_hyperpigmentation	1.60616583
29	MP0000631_abnormal_neuroendocrine_gland	1.55742571
30	MP0002234_abnormal_pharynx_morphology	1.54831447
31	MP0001486_abnormal_startle_reflex	1.53884571
32	MP0005645_abnormal_hypothalamus_physiol	1.53724301
33	MP0002557_abnormal_social/conspecific_i	1.53313167
34	MP0003122_maternal_imprinting	1.49270465
35	MP0004742_abnormal_vestibular_system	1.48964602
36	MP0008789_abnormal_olfactory_epithelium	1.48826307
37	MP0002733_abnormal_thermal_nociception	1.48550083
38	MP0002876_abnormal_thyroid_physiology	1.48022149
39	MP0001919_abnormal_reproductive_system	1.46920459
40	MP0001485_abnormal_pinna_reflex	1.46286592
41	MP0008877_abnormal_DNA_methylation	1.45947417
42	MP0005423_abnormal_somatic_nervous	1.45130443
43	MP0001440_abnormal_grooming_behavior	1.41224488
44	MP0001970_abnormal_pain_threshold	1.35556698
45	MP0002822_catalepsy	1.35127742
46	MP0000230_abnormal_systemic_arterial	1.32504298
47	MP0009745_abnormal_behavioral_response	1.31794650
48	MP0005167_abnormal_blood-brain_barrier	1.31704569
49	MP0006072_abnormal_retinal_apoptosis	1.30956523
50	MP0004133_heterotaxia	1.28804077
51	MP0003635_abnormal_synaptic_transmissio	1.27331384
52	MP0005410_abnormal_fertilization	1.25616658
53	MP0002138_abnormal_hepatobiliary_system	1.25466024
54	MP0002572_abnormal_emotion/affect_behav	1.24719966
55	MP0001879_abnormal_lymphatic_vessel	1.23936874
56	MP0005499_abnormal_olfactory_system	1.23763035
57	MP0005394_taste/olfaction_phenotype	1.23763035
58	MP0005670_abnormal_white_adipose	1.23493726
59	MP0000026_abnormal_inner_ear	1.22881813
60	MP0005253_abnormal_eye_physiology	1.21487625
61	MP0002163_abnormal_gland_morphology	1.17051947
62	MP0002909_abnormal_adrenal_gland	1.16481742
63	MP0003787_abnormal_imprinting	1.15107717
64	MP0001963_abnormal_hearing_physiology	1.14597537
65	MP0005084_abnormal_gallbladder_morpholo	1.14254122
66	MP0003119_abnormal_digestive_system	1.14131985
67	MP0001501_abnormal_sleep_pattern	1.13716980
68	MP0002638_abnormal_pupillary_reflex	1.12172033
69	MP0002063_abnormal_learning/memory/cond	1.11673853
70	MP0005389_reproductive_system_phenotype	1.11107925
71	MP0004130_abnormal_muscle_cell	1.09904858
72	MP0002938_white_spotting	1.08693475
73	MP0005174_abnormal_tail_pigmentation	1.08517568
74	MP0002095_abnormal_skin_pigmentation	1.07465094
75	MP0000049_abnormal_middle_ear	1.06564973
76	MP0000778_abnormal_nervous_system	1.06464965
77	MP0004859_abnormal_synaptic_plasticity	1.06076039
78	MP0002160_abnormal_reproductive_system	1.05796183
79	MP0005464_abnormal_platelet_physiology	1.01326398
80	MP0002837_dystrophic_cardiac_calcinosis	0.99850725
81	MP0002752_abnormal_somatic_nervous	0.99137461
82	MP0002064_seizures	0.98424512
83	MP0002067_abnormal_sensory_capabilities	0.98016752
84	MP0002184_abnormal_innervation	0.96796969
85	MP0008775_abnormal_heart_ventricle	0.96289707
86	MP0002928_abnormal_bile_duct	0.94891779
87	MP0001986_abnormal_taste_sensitivity	0.89897610
88	MP0001905_abnormal_dopamine_level	0.89133715
89	MP0005360_urolithiasis	0.87910034
90	MP0002734_abnormal_mechanical_nocicepti	0.86726402
91	MP0010329_abnormal_lipoprotein_level	0.84964112
92	MP0004085_abnormal_heartbeat	0.81445467
93	MP0003938_abnormal_ear_development	0.79899431
94	MP0004036_abnormal_muscle_relaxation	0.78669247
95	MP0003283_abnormal_digestive_organ	0.77408924
96	MP0002229_neurodegeneration	0.76381575
97	MP0001293_anophthalmia	0.76256624
98	MP0005195_abnormal_posterior_eye	0.75995879
99	MP0000015_abnormal_ear_pigmentation	0.75959428
100	MP0000955_abnormal_spinal_cord	0.75804571

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Decreased central vision (HP:0007663)	3.87991703
2	Molar tooth sign on MRI (HP:0002419)	3.45306706
3	Abnormality of midbrain morphology (HP:0002418)	3.45306706
4	Pancreatic cysts (HP:0001737)	3.43588430
5	Type II lissencephaly (HP:0007260)	3.26715524
6	Pancreatic fibrosis (HP:0100732)	3.25610147
7	Nephronophthisis (HP:0000090)	3.23603720
8	Medial flaring of the eyebrow (HP:0010747)	3.00053670
9	Gait imbalance (HP:0002141)	2.86737898
10	Congenital stationary night blindness (HP:0007642)	2.81540089
11	Nephrogenic diabetes insipidus (HP:0009806)	2.80321377
12	True hermaphroditism (HP:0010459)	2.79229391
13	Abnormality of the renal medulla (HP:0100957)	2.77551708
14	Lipid accumulation in hepatocytes (HP:0006561)	2.76759469
15	Congenital primary aphakia (HP:0007707)	2.73759923
16	Acute encephalopathy (HP:0006846)	2.73543016
17	Thyroid-stimulating hormone excess (HP:0002925)	2.69494590
18	Abnormality of the renal cortex (HP:0011035)	2.59879409
19	Acute necrotizing encephalopathy (HP:0006965)	2.58870901
20	Genetic anticipation (HP:0003743)	2.57863174
21	Poor coordination (HP:0002370)	2.55860577
22	Abnormal hemoglobin (HP:0011902)	2.48861295
23	Hyperglycinemia (HP:0002154)	2.47422311
24	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.45391554
25	Mitochondrial inheritance (HP:0001427)	2.38523118
26	Lissencephaly (HP:0001339)	2.36539397
27	Abnormality of macular pigmentation (HP:0008002)	2.36319451
28	Polydipsia (HP:0001959)	2.33547775
29	Abnormal drinking behavior (HP:0030082)	2.33547775
30	Prolonged bleeding time (HP:0003010)	2.31321280
31	Progressive cerebellar ataxia (HP:0002073)	2.28420256
32	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.25811771
33	Abnormal mitochondria in muscle tissue (HP:0008316)	2.25028354
34	Acanthocytosis (HP:0001927)	2.23841946
35	Abnormal respiratory epithelium morphology (HP:0012253)	2.22098484
36	Abnormal respiratory motile cilium morphology (HP:0005938)	2.22098484
37	Arthropathy (HP:0003040)	2.21913152
38	Cystic liver disease (HP:0006706)	2.21130813
39	Petechiae (HP:0000967)	2.21095075
40	Hyperlipoproteinemia (HP:0010980)	2.19818548
41	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.18788050
42	Cerebellar dysplasia (HP:0007033)	2.18604913
43	Febrile seizures (HP:0002373)	2.17486121
44	Abnormal rod and cone electroretinograms (HP:0008323)	2.15890063
45	Chronic hepatic failure (HP:0100626)	2.15157899
46	Polyphagia (HP:0002591)	2.15080133
47	Failure to thrive in infancy (HP:0001531)	2.14415302
48	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.13964344
49	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.12514313
50	Anencephaly (HP:0002323)	2.11903113
51	Attenuation of retinal blood vessels (HP:0007843)	2.11452302
52	Abolished electroretinogram (ERG) (HP:0000550)	2.10149622
53	Vaginal atresia (HP:0000148)	2.08131876
54	Absent/shortened dynein arms (HP:0200106)	2.06992839
55	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.06992839
56	Genital tract atresia (HP:0001827)	2.06967114
57	Pendular nystagmus (HP:0012043)	2.06565943
58	Progressive macrocephaly (HP:0004481)	2.06096512
59	Increased CSF lactate (HP:0002490)	2.04352462
60	Bony spicule pigmentary retinopathy (HP:0007737)	2.04273304
61	Abnormality of alanine metabolism (HP:0010916)	2.03998164
62	Hyperalaninemia (HP:0003348)	2.03998164
63	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.03998164
64	Agitation (HP:0000713)	2.01162192
65	Myokymia (HP:0002411)	2.00508085
66	Postaxial foot polydactyly (HP:0001830)	2.00138865
67	Congenital sensorineural hearing impairment (HP:0008527)	1.99904656
68	Sclerocornea (HP:0000647)	1.99420076
69	Pachygyria (HP:0001302)	1.98692182
70	Absent thumb (HP:0009777)	1.98457485
71	Tubulointerstitial nephritis (HP:0001970)	1.97357626
72	Renal cortical cysts (HP:0000803)	1.96179246
73	Enlarged kidneys (HP:0000105)	1.95282149
74	Poikilocytosis (HP:0004447)	1.94476487
75	Short tibia (HP:0005736)	1.93703707
76	Increased muscle lipid content (HP:0009058)	1.90366962
77	Abnormality of DNA repair (HP:0003254)	1.87760467
78	Decreased circulating renin level (HP:0003351)	1.87673242
79	Abnormality of the nasal septum (HP:0000419)	1.87416996
80	Pallor (HP:0000980)	1.87038500
81	Bulbous nose (HP:0000414)	1.85248527
82	Congenital hepatic fibrosis (HP:0002612)	1.85123749
83	Methylmalonic acidemia (HP:0002912)	1.83178512
84	Increased corneal curvature (HP:0100692)	1.81708342
85	Keratoconus (HP:0000563)	1.81708342
86	Dyskinesia (HP:0100660)	1.78736606
87	Epileptic encephalopathy (HP:0200134)	1.78615883
88	Severe visual impairment (HP:0001141)	1.76881793
89	Male pseudohermaphroditism (HP:0000037)	1.76688045
90	Tubular atrophy (HP:0000092)	1.76616959
91	Occipital encephalocele (HP:0002085)	1.75927119
92	Specific learning disability (HP:0001328)	1.75536395
93	Methylmalonic aciduria (HP:0012120)	1.75400357
94	Postaxial hand polydactyly (HP:0001162)	1.74803063
95	Abnormal ciliary motility (HP:0012262)	1.74678378
96	Menorrhagia (HP:0000132)	1.74187555
97	Renal Fanconi syndrome (HP:0001994)	1.73932908
98	Hepatocellular necrosis (HP:0001404)	1.73596395
99	Abnormality of dental color (HP:0011073)	1.72732652
100	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.72074639

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	4.62650812
2	AKT3	3.22841351
3	MAP4K2	3.22456823
4	WNK4	3.03590528
5	ADRBK2	2.95773609
6	INSRR	2.92457635
7	FRK	2.91451538
8	TLK1	2.58981601
9	GRK1	2.08133461
10	MAP3K4	2.02777613
11	STK39	1.91743959
12	ZAK	1.90406950
13	CAMKK2	1.84134029
14	PINK1	1.79103858
15	MAPK13	1.72672898
16	CASK	1.65711636
17	DYRK2	1.59066213
18	WNK3	1.46002107
19	MAP2K2	1.45699403
20	BMPR1B	1.45663754
21	SIK2	1.43099706
22	MAP2K7	1.38073372
23	DAPK2	1.30443316
24	ADRBK1	1.22781592
25	TXK	1.21767393
26	NUAK1	1.16291486
27	PAK3	1.12816175
28	SGK2	1.10323448
29	CAMK1	1.04615342
30	TNK2	1.03415490
31	MST4	1.02049682
32	CSNK1A1L	1.00656060
33	CSNK1G2	1.00609318
34	SGK494	0.99264616
35	SGK223	0.99264616
36	CDK8	0.98505018
37	TNIK	0.96530596
38	NTRK2	0.96316075
39	MARK1	0.89992058
40	DYRK3	0.89568920
41	CSNK1G3	0.89322393
42	BCKDK	0.88724122
43	STK11	0.84329312
44	NTRK3	0.83017173
45	TIE1	0.81718085
46	PRKCG	0.81682480
47	ERN1	0.81500386
48	CAMK4	0.80977369
49	CAMKK1	0.76987213
50	MAP3K9	0.76360232
51	OXSR1	0.75871793
52	CSNK1G1	0.75156095
53	OBSCN	0.75101553
54	EPHA3	0.71704130
55	PHKG1	0.70743525
56	PHKG2	0.70743525
57	PRKACA	0.70692501
58	IKBKB	0.70369654
59	PRKCQ	0.70035806
60	PIK3CG	0.68380947
61	PKN1	0.68194325
62	ERBB2	0.65757418
63	MYLK	0.65111301
64	BCR	0.65070264
65	PIK3CA	0.65008873
66	TEC	0.62009032
67	EPHA4	0.61810184
68	ACVR1B	0.61786938
69	GRK5	0.61033094
70	MAP2K1	0.60433867
71	PLK2	0.60253177
72	CAMK2A	0.59006641
73	RPS6KA5	0.57937829
74	BTK	0.56582115
75	DYRK1A	0.56427092
76	PRKCZ	0.56157788
77	WNK1	0.55531611
78	PTK2B	0.54795706
79	MATK	0.52936186
80	PRKACG	0.52140721
81	AURKA	0.51933316
82	CAMK1D	0.49409848
83	PRKCA	0.49249708
84	PRKCE	0.48762325
85	CAMK1G	0.48749499
86	PDK2	0.48024584
87	SYK	0.47698673
88	MARK2	0.46515524
89	GRK6	0.45617733
90	PLK4	0.45595179
91	PRKG1	0.45101030
92	MAP2K4	0.45069860
93	STK38L	0.44838685
94	BRAF	0.43283981
95	DAPK3	0.42835172
96	SGK3	0.42037003
97	CSNK1A1	0.41411942
98	PRKD3	0.39964986
99	DYRK1B	0.38122927
100	BMX	0.37513457

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.20562602
2	Nicotine addiction_Homo sapiens_hsa05033	2.54352498
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.51683446
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.46146826
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.40525067
6	Phototransduction_Homo sapiens_hsa04744	2.21465739
7	Olfactory transduction_Homo sapiens_hsa04740	2.13729861
8	Morphine addiction_Homo sapiens_hsa05032	1.99599549
9	Sulfur relay system_Homo sapiens_hsa04122	1.94496784
10	Parkinsons disease_Homo sapiens_hsa05012	1.90031282
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.81080694
12	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.80612567
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.79419409
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.71167256
15	Ribosome_Homo sapiens_hsa03010	1.69173556
16	Serotonergic synapse_Homo sapiens_hsa04726	1.68659341
17	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.68615301
18	GABAergic synapse_Homo sapiens_hsa04727	1.67946566
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.64107372
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.57057579
21	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.46297396
22	Huntingtons disease_Homo sapiens_hsa05016	1.45489975
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.42643094
24	Alzheimers disease_Homo sapiens_hsa05010	1.40898970
25	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.39884544
26	Taste transduction_Homo sapiens_hsa04742	1.39405126
27	Circadian entrainment_Homo sapiens_hsa04713	1.38938850
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.38187562
29	Sulfur metabolism_Homo sapiens_hsa00920	1.37793979
30	Basal transcription factors_Homo sapiens_hsa03022	1.36908802
31	Butanoate metabolism_Homo sapiens_hsa00650	1.34057419
32	Steroid biosynthesis_Homo sapiens_hsa00100	1.32588972
33	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.32145417
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.30850507
35	Insulin secretion_Homo sapiens_hsa04911	1.29105606
36	Retinol metabolism_Homo sapiens_hsa00830	1.27692476
37	Fat digestion and absorption_Homo sapiens_hsa04975	1.24465626
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.24032328
39	Collecting duct acid secretion_Homo sapiens_hsa04966	1.23269051
40	Glutamatergic synapse_Homo sapiens_hsa04724	1.20883072
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.19560457
42	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.15808296
43	Ether lipid metabolism_Homo sapiens_hsa00565	1.15456978
44	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.11240911
45	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.09808937
46	Alcoholism_Homo sapiens_hsa05034	1.09512363
47	beta-Alanine metabolism_Homo sapiens_hsa00410	1.03616948
48	Tryptophan metabolism_Homo sapiens_hsa00380	1.01401155
49	Caffeine metabolism_Homo sapiens_hsa00232	1.00570596
50	Protein export_Homo sapiens_hsa03060	0.99174661
51	Peroxisome_Homo sapiens_hsa04146	0.96978444
52	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.95993770
53	Regulation of autophagy_Homo sapiens_hsa04140	0.92586232
54	RNA polymerase_Homo sapiens_hsa03020	0.90146611
55	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.89653741
56	Salivary secretion_Homo sapiens_hsa04970	0.89593520
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.86867796
58	Propanoate metabolism_Homo sapiens_hsa00640	0.84924651
59	Cholinergic synapse_Homo sapiens_hsa04725	0.84237152
60	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.83763332
61	Calcium signaling pathway_Homo sapiens_hsa04020	0.83446201
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.82967614
63	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.82577914
64	Arginine and proline metabolism_Homo sapiens_hsa00330	0.82573815
65	Dopaminergic synapse_Homo sapiens_hsa04728	0.82276085
66	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.80159803
67	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.79226402
68	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.74987882
69	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.69146476
70	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.67088206
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66165606
72	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.64196428
73	Fanconi anemia pathway_Homo sapiens_hsa03460	0.63770900
74	ABC transporters_Homo sapiens_hsa02010	0.63184232
75	Selenocompound metabolism_Homo sapiens_hsa00450	0.60861688
76	Phenylalanine metabolism_Homo sapiens_hsa00360	0.60612060
77	Pancreatic secretion_Homo sapiens_hsa04972	0.57954232
78	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.57744733
79	Gastric acid secretion_Homo sapiens_hsa04971	0.57404254
80	Metabolic pathways_Homo sapiens_hsa01100	0.57276665
81	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.56827916
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.56651868
83	Bile secretion_Homo sapiens_hsa04976	0.54994834
84	Amphetamine addiction_Homo sapiens_hsa05031	0.54864572
85	Long-term depression_Homo sapiens_hsa04730	0.54448951
86	cAMP signaling pathway_Homo sapiens_hsa04024	0.54401493
87	Cocaine addiction_Homo sapiens_hsa05030	0.53051577
88	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.51383458
89	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.51037130
90	Tyrosine metabolism_Homo sapiens_hsa00350	0.48418133
91	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.47636796
92	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.47075136
93	Homologous recombination_Homo sapiens_hsa03440	0.45495357
94	Renin secretion_Homo sapiens_hsa04924	0.43901313
95	Platelet activation_Homo sapiens_hsa04611	0.43213887
96	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.42267006
97	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.40021803
98	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.39804445
99	Ras signaling pathway_Homo sapiens_hsa04014	0.38891855
100	One carbon pool by folate_Homo sapiens_hsa00670	0.38865852

MTRNR2L5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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