MTRNR2L6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to Golgi (GO:0072600)5.01089806
2interkinetic nuclear migration (GO:0022027)4.49290330
3nuclear pore complex assembly (GO:0051292)4.46930590
4retrograde transport, vesicle recycling within Golgi (GO:0000301)4.45406790
5protein targeting to Golgi (GO:0000042)4.29540001
6negative regulation of vascular permeability (GO:0043116)4.26360865
7bundle of His cell to Purkinje myocyte communication (GO:0086069)4.05849576
8regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.99908321
9cytoplasmic mRNA processing body assembly (GO:0033962)3.93378260
10thrombin receptor signaling pathway (GO:0070493)3.82053144
11nuclear pore organization (GO:0006999)3.71026696
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.65595775
13positive regulation of endothelial cell differentiation (GO:0045603)3.56900641
14artery development (GO:0060840)3.54341962
15phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.50347281
16positive regulation of muscle hypertrophy (GO:0014742)3.48556559
17positive regulation of cardiac muscle hypertrophy (GO:0010613)3.48556559
18protein K48-linked deubiquitination (GO:0071108)3.45735639
19pore complex assembly (GO:0046931)3.37347575
20negative regulation of neurotransmitter secretion (GO:0046929)3.35286557
21negative regulation of protein localization to cell surface (GO:2000009)3.32326155
22regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.30176905
23regulation of lipoprotein metabolic process (GO:0050746)3.29472093
24carnitine shuttle (GO:0006853)3.28216435
25early endosome to late endosome transport (GO:0045022)3.24324699
26regulation of clathrin-mediated endocytosis (GO:2000369)3.22175527
27regulation of transforming growth factor beta2 production (GO:0032909)3.21049422
28sleep (GO:0030431)3.00569792
29negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.99364671
30keratinization (GO:0031424)2.95956475
31embryonic retina morphogenesis in camera-type eye (GO:0060059)2.88827669
32positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.87117127
33COPII vesicle coating (GO:0048208)2.87107146
34fatty acid transmembrane transport (GO:1902001)2.87106117
35macroautophagy (GO:0016236)2.86564233
36regulation of endothelial cell differentiation (GO:0045601)2.85206752
37microtubule nucleation (GO:0007020)2.83928412
38fibroblast migration (GO:0010761)2.83914740
39microtubule anchoring (GO:0034453)2.83561188
40regulation of cell communication by electrical coupling (GO:0010649)2.83329470
41negative regulation of neurotransmitter transport (GO:0051589)2.82382750
42positive regulation of glycolytic process (GO:0045821)2.82147828
43lymphangiogenesis (GO:0001946)2.78553575
44positive regulation of Rho protein signal transduction (GO:0035025)2.78030815
45protein localization to Golgi apparatus (GO:0034067)2.77102970
46long-chain fatty acid biosynthetic process (GO:0042759)2.75664397
47regulation of establishment of cell polarity (GO:2000114)2.74702009
48Golgi to plasma membrane protein transport (GO:0043001)2.72570668
49intra-Golgi vesicle-mediated transport (GO:0006891)2.71059595
50microtubule depolymerization (GO:0007019)2.71006730
51cyclic nucleotide catabolic process (GO:0009214)2.68347533
52desmosome organization (GO:0002934)2.66529685
53biotin metabolic process (GO:0006768)2.63581182
54protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.63534959
55mesodermal cell differentiation (GO:0048333)2.61999197
56nucleus localization (GO:0051647)2.61455394
57synaptic vesicle docking involved in exocytosis (GO:0016081)2.60684654
58negative regulation of blood circulation (GO:1903523)2.58124722
59regulation of cardiac muscle hypertrophy (GO:0010611)2.58019416
60establishment of skin barrier (GO:0061436)2.57457765
61Golgi to plasma membrane transport (GO:0006893)2.57449053
62regulation of pigment cell differentiation (GO:0050932)2.54221072
63regulation of muscle hypertrophy (GO:0014743)2.52719393
64negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.52234282
65regulation of female receptivity (GO:0045924)2.52029664
66Golgi to endosome transport (GO:0006895)2.49532733
67multicellular organismal movement (GO:0050879)2.48512402
68musculoskeletal movement (GO:0050881)2.48512402
69regulation of steroid hormone biosynthetic process (GO:0090030)2.47725086
70regulation of glycolytic process (GO:0006110)2.45964297
71regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.44327624
72regulation of relaxation of muscle (GO:1901077)2.43367144
73regulation of sarcomere organization (GO:0060297)2.42383405
74regulation of cAMP-dependent protein kinase activity (GO:2000479)2.41900127
75phospholipid translocation (GO:0045332)2.41228843
76lipid translocation (GO:0034204)2.41228843
77regulation of establishment or maintenance of cell polarity (GO:0032878)2.40701185
78ventricular cardiac muscle cell action potential (GO:0086005)2.39871787
79receptor recycling (GO:0001881)2.39724090
80negative regulation of translation, ncRNA-mediated (GO:0040033)2.38919424
81regulation of translation, ncRNA-mediated (GO:0045974)2.38919424
82negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.38919424
83regulation of protein localization to cell surface (GO:2000008)2.38581636
84carnitine transmembrane transport (GO:1902603)2.37656513
85linoleic acid metabolic process (GO:0043651)2.37250823
86regulation of energy homeostasis (GO:2000505)2.36736005
87regulation of NFAT protein import into nucleus (GO:0051532)2.36439773
88regulation of alkaline phosphatase activity (GO:0010692)2.36431483
89embryonic camera-type eye morphogenesis (GO:0048596)2.34891471
90microtubule polymerization or depolymerization (GO:0031109)2.34849400
91protein localization to microtubule cytoskeleton (GO:0072698)2.34665559
92protein K11-linked deubiquitination (GO:0035871)2.33934988
93cAMP catabolic process (GO:0006198)2.31162866
94genitalia morphogenesis (GO:0035112)2.30602480
95vesicle transport along microtubule (GO:0047496)2.30330671
96regulation of muscle adaptation (GO:0043502)2.29597987
97protein K63-linked deubiquitination (GO:0070536)2.28630377
98coronary vasculature morphogenesis (GO:0060977)2.27433389
99carnitine transport (GO:0015879)2.24825973
100amino-acid betaine transport (GO:0015838)2.24825973

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.99756729
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.00922829
3GBX2_23144817_ChIP-Seq_PC3_Human2.99776488
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.95755362
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.64196517
6AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.53384357
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48409614
8CDX2_19796622_ChIP-Seq_MESCs_Mouse2.46681886
9SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.34590758
10TAF15_26573619_Chip-Seq_HEK293_Human2.34291356
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.28461880
12PIAS1_25552417_ChIP-Seq_VCAP_Human2.22893522
13SMAD4_21799915_ChIP-Seq_A2780_Human2.17505950
14IGF1R_20145208_ChIP-Seq_DFB_Human2.02317591
15AR_21572438_ChIP-Seq_LNCaP_Human1.97393495
16GATA1_22025678_ChIP-Seq_K562_Human1.92724354
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90128647
18STAT3_23295773_ChIP-Seq_U87_Human1.88391601
19P300_19829295_ChIP-Seq_ESCs_Human1.77749459
20MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.75796543
21AHR_22903824_ChIP-Seq_MCF-7_Human1.68789528
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65839155
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65144170
24FUS_26573619_Chip-Seq_HEK293_Human1.64492588
25ARNT_22903824_ChIP-Seq_MCF-7_Human1.63923420
26FOXM1_26456572_ChIP-Seq_MCF-7_Human1.63877426
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63869210
28OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63296692
29TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.60390293
30TCF4_23295773_ChIP-Seq_U87_Human1.58604323
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.58283000
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54303892
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54261470
34CTNNB1_20460455_ChIP-Seq_HCT116_Human1.53466456
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51749811
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.48472797
37TCF4_18268006_ChIP-ChIP_LS174T_Human1.47802880
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46356001
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.46290005
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45117959
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43980573
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42201294
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.41489906
44TP53_16413492_ChIP-PET_HCT116_Human1.39627356
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.37463454
46CBP_20019798_ChIP-Seq_JUKART_Human1.36144743
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36144743
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34420321
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34251868
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34113981
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34113981
52AR_25329375_ChIP-Seq_VCAP_Human1.33823986
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.28574653
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.26027812
55CJUN_26792858_Chip-Seq_BT549_Human1.25367208
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.25203670
57E2F1_18555785_Chip-Seq_ESCs_Mouse1.25125853
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.23732226
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20743514
60ER_23166858_ChIP-Seq_MCF-7_Human1.20464189
61CDX2_22108803_ChIP-Seq_LS180_Human1.20376915
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19611825
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19475441
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.18103328
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18024826
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16588422
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14620138
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.14114362
69TP53_18474530_ChIP-ChIP_U2OS_Human1.12961848
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.12812468
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12226456
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11894389
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10436118
74TP63_23658742_ChIP-Seq_EP156T_Human1.08667142
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08551725
76P53_22387025_ChIP-Seq_ESCs_Mouse1.08345916
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08069012
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.07333992
79EWS_26573619_Chip-Seq_HEK293_Human1.06752614
80TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05210507
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04042199
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03542048
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03138288
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02633447
85RUNX2_22187159_ChIP-Seq_PCA_Human1.02535539
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02171259
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01376990
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01376990
89TCF4_22108803_ChIP-Seq_LS180_Human1.01259274
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01207995
91AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01194826
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01055734
93TBL1_22424771_ChIP-Seq_293T_Human1.00506930
94EZH2_22144423_ChIP-Seq_EOC_Human1.00133525
95RXR_22108803_ChIP-Seq_LS180_Human0.97948403
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95921829
97TAL1_26923725_Chip-Seq_HPCs_Mouse0.95830368
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95696952
99VDR_22108803_ChIP-Seq_LS180_Human0.95188908
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95052186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.99938704
2MP0002009_preneoplasia3.82924720
3MP0008057_abnormal_DNA_replication3.18538793
4MP0000569_abnormal_digit_pigmentation3.17887725
5MP0004036_abnormal_muscle_relaxation3.09753396
6MP0004084_abnormal_cardiac_muscle3.08661989
7MP0003646_muscle_fatigue3.08350048
8MP0009697_abnormal_copulation2.94326300
9MP0000465_gastrointestinal_hemorrhage2.61683404
10MP0009780_abnormal_chondrocyte_physiolo2.50623289
11MP0004130_abnormal_muscle_cell2.35014260
12MP0003941_abnormal_skin_development2.22558157
13MP0005409_darkened_coat_color2.22044714
14MP0004510_myositis2.13967275
15MP0004233_abnormal_muscle_weight2.12157911
16MP0001879_abnormal_lymphatic_vessel2.08295386
17MP0008004_abnormal_stomach_pH2.05209360
18MP0005670_abnormal_white_adipose2.02256243
19MP0005646_abnormal_pituitary_gland2.02224635
20MP0004484_altered_response_of1.86198662
21MP0005187_abnormal_penis_morphology1.85662365
22MP0005083_abnormal_biliary_tract1.81462161
23MP0003950_abnormal_plasma_membrane1.75917193
24MP0000383_abnormal_hair_follicle1.70774485
25MP0003183_abnormal_peptide_metabolism1.64057681
26MP0001661_extended_life_span1.57664864
27MP0004134_abnormal_chest_morphology1.56832449
28MP0001666_abnormal_nutrient_absorption1.56642112
29MP0004215_abnormal_myocardial_fiber1.55804584
30MP0005464_abnormal_platelet_physiology1.54049657
31MP0010368_abnormal_lymphatic_system1.53202766
32MP0004264_abnormal_extraembryonic_tissu1.53187061
33MP0005275_abnormal_skin_tensile1.50489468
34MP0008775_abnormal_heart_ventricle1.49761530
35MP0009046_muscle_twitch1.48460716
36MP0006138_congestive_heart_failure1.45931661
37MP0005167_abnormal_blood-brain_barrier1.45745994
38MP0003879_abnormal_hair_cell1.45458432
39MP0002876_abnormal_thyroid_physiology1.43424158
40MP0003868_abnormal_feces_composition1.40956140
41MP0003045_fibrosis1.37477841
42MP0000013_abnormal_adipose_tissue1.34975278
43MP0005365_abnormal_bile_salt1.33578545
44MP0004270_analgesia1.29776674
45MP0005085_abnormal_gallbladder_physiolo1.28013038
46MP0004085_abnormal_heartbeat1.27381355
47MP0010329_abnormal_lipoprotein_level1.27143005
48MP0004145_abnormal_muscle_electrophysio1.26817975
49MP0010678_abnormal_skin_adnexa1.20966124
50MP0003828_pulmonary_edema1.20163125
51MP0009115_abnormal_fat_cell1.20006147
52MP0000003_abnormal_adipose_tissue1.15417953
53MP0000230_abnormal_systemic_arterial1.13637409
54MP0005620_abnormal_muscle_contractility1.13264268
55MP0002166_altered_tumor_susceptibility1.12733484
56MP0000427_abnormal_hair_cycle1.07100291
57MP0005410_abnormal_fertilization1.06301625
58MP0002332_abnormal_exercise_endurance1.05637281
59MP0001486_abnormal_startle_reflex1.05360672
60MP0002972_abnormal_cardiac_muscle1.04235764
61MP0003890_abnormal_embryonic-extraembry1.04190754
62MP0002106_abnormal_muscle_physiology1.01977256
63MP0003566_abnormal_cell_adhesion1.01016668
64MP0005386_behavior/neurological_phenoty0.98981755
65MP0004924_abnormal_behavior0.98981755
66MP0004087_abnormal_muscle_fiber0.95181771
67MP0003718_maternal_effect0.93976226
68MP0004272_abnormal_basement_membrane0.92289488
69MP0005666_abnormal_adipose_tissue0.91518505
70MP0000733_abnormal_muscle_development0.89836603
71MP0002971_abnormal_brown_adipose0.89368192
72MP0008961_abnormal_basal_metabolism0.87845251
73MP0001299_abnormal_eye_distance/0.87376797
74MP0000647_abnormal_sebaceous_gland0.85779740
75MP0005385_cardiovascular_system_phenoty0.84497990
76MP0001544_abnormal_cardiovascular_syste0.84497990
77MP0005375_adipose_tissue_phenotype0.81625794
78MP0005369_muscle_phenotype0.78908801
79MP0001765_abnormal_ion_homeostasis0.75561508
80MP0002796_impaired_skin_barrier0.75531585
81MP0001784_abnormal_fluid_regulation0.75467384
82MP0001191_abnormal_skin_condition0.75122189
83MP0002127_abnormal_cardiovascular_syste0.74914510
84MP0001501_abnormal_sleep_pattern0.71464152
85MP0000749_muscle_degeneration0.71388356
86MP0000249_abnormal_blood_vessel0.71366569
87MP0004147_increased_porphyrin_level0.69100759
88MP0002006_tumorigenesis0.69064805
89MP0002118_abnormal_lipid_homeostasis0.68070749
90MP0000759_abnormal_skeletal_muscle0.66565316
91MP0001851_eye_inflammation0.66343739
92MP0002128_abnormal_blood_circulation0.64096261
93MP0005266_abnormal_metabolism0.63285542
94MP0003633_abnormal_nervous_system0.62485201
95MP0010630_abnormal_cardiac_muscle0.61472879
96MP0003984_embryonic_growth_retardation0.59472943
97MP0002086_abnormal_extraembryonic_tissu0.58920360
98MP0005645_abnormal_hypothalamus_physiol0.58014775
99MP0005165_increased_susceptibility_to0.57249065
100MP0008877_abnormal_DNA_methylation0.56627671

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)5.02278908
2Increased mean platelet volume (HP:0011877)3.49906060
3Nemaline bodies (HP:0003798)3.44648578
4Right ventricular cardiomyopathy (HP:0011663)3.44427842
5Menorrhagia (HP:0000132)3.44394289
6Tubulointerstitial nephritis (HP:0001970)3.26981023
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.10096903
8Acanthocytosis (HP:0001927)3.06566392
9Hyperkalemia (HP:0002153)3.03661446
10Papilledema (HP:0001085)3.01204752
11Muscle fiber inclusion bodies (HP:0100299)3.01165608
12Prolonged bleeding time (HP:0003010)2.93435473
13Petechiae (HP:0000967)2.92673835
14Abnormal platelet volume (HP:0011876)2.92196357
15Overgrowth (HP:0001548)2.87904852
16Thyroid carcinoma (HP:0002890)2.69948373
17Abnormality of the left ventricular outflow tract (HP:0011103)2.67255007
18Subaortic stenosis (HP:0001682)2.67255007
19Truncal obesity (HP:0001956)2.67181573
20Genetic anticipation (HP:0003743)2.64430793
21Bundle branch block (HP:0011710)2.58324210
22Abnormal auditory evoked potentials (HP:0006958)2.57495247
23Acute myeloid leukemia (HP:0004808)2.57363296
24Neonatal hypoglycemia (HP:0001998)2.54589919
25Insulin-resistant diabetes mellitus (HP:0000831)2.53165698
26Gingival bleeding (HP:0000225)2.50918404
27Fair hair (HP:0002286)2.50392829
28Renal cortical cysts (HP:0000803)2.45470688
29Sudden death (HP:0001699)2.44168447
30Medulloblastoma (HP:0002885)2.43670229
31Hyperventilation (HP:0002883)2.43180208
32Insidious onset (HP:0003587)2.41226523
33Termporal pattern (HP:0011008)2.41226523
34Hypoplastic labia majora (HP:0000059)2.41197766
35Aplasia/Hypoplasia of the tibia (HP:0005772)2.34756639
36Abnormality of the astrocytes (HP:0100707)2.34710554
37Astrocytoma (HP:0009592)2.34710554
38Chronic hepatic failure (HP:0100626)2.28937093
39Hypoalphalipoproteinemia (HP:0003233)2.26869347
40Progressive cerebellar ataxia (HP:0002073)2.25350495
41Abnormality of the labia majora (HP:0012881)2.25266853
42Autoamputation (HP:0001218)2.24001438
43Facial diplegia (HP:0001349)2.21343995
44Abnormality of the axillary hair (HP:0100134)2.14663538
45Abnormality of secondary sexual hair (HP:0009888)2.14663538
46Gaze-evoked nystagmus (HP:0000640)2.12980864
47Absent eyelashes (HP:0000561)2.12322314
48Abnormality of the fingertips (HP:0001211)2.11885917
49Neoplasm of the heart (HP:0100544)2.11269161
50Febrile seizures (HP:0002373)2.10232330
51Exercise-induced myalgia (HP:0003738)2.08529369
52Abnormality of the renal cortex (HP:0011035)2.07963914
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.06556939
54Dysmetric saccades (HP:0000641)2.06259564
55Generalized hypopigmentation of hair (HP:0011358)2.05103280
56Conjunctival telangiectasia (HP:0000524)2.04904042
57Neoplasm of striated muscle (HP:0009728)2.03810076
58Portal hypertension (HP:0001409)2.03032722
59Menstrual irregularities (HP:0000858)2.02032132
60Abnormality of the ischium (HP:0003174)2.01545999
61Abnormality of potassium homeostasis (HP:0011042)2.00053623
62Poikilocytosis (HP:0004447)1.96424504
63Short chin (HP:0000331)1.95672291
64Urinary urgency (HP:0000012)1.95652941
65Abnormality of the nasal septum (HP:0000419)1.94311024
66Epistaxis (HP:0000421)1.94094256
67Broad ribs (HP:0000885)1.94054207
68Lip pit (HP:0100267)1.92688834
69Atonic seizures (HP:0010819)1.92019965
70Curly hair (HP:0002212)1.91694548
71Absent eyebrow (HP:0002223)1.90184253
72Ventricular tachycardia (HP:0004756)1.88797077
73Distal lower limb amyotrophy (HP:0008944)1.88186024
74Epileptiform EEG discharges (HP:0011182)1.88172622
75Asymmetric septal hypertrophy (HP:0001670)1.88070615
76Deep philtrum (HP:0002002)1.87484443
77Metaphyseal dysplasia (HP:0100255)1.87284357
78Hyporeflexia of lower limbs (HP:0002600)1.86481590
79Prominent nose (HP:0000448)1.85370526
80Submucous cleft hard palate (HP:0000176)1.84477568
81Osteolytic defects of the phalanges of the hand (HP:0009771)1.83737046
82Osteolytic defects of the hand bones (HP:0009699)1.83737046
83Hypolipoproteinemia (HP:0010981)1.82717923
84Rhabdomyosarcoma (HP:0002859)1.82554601
85Myoglobinuria (HP:0002913)1.82493345
86Urinary bladder sphincter dysfunction (HP:0002839)1.82466344
87Glioma (HP:0009733)1.82232712
88EEG with generalized epileptiform discharges (HP:0011198)1.81784658
89Spontaneous hematomas (HP:0007420)1.80418719
90Hepatoblastoma (HP:0002884)1.80407347
91Cone-rod dystrophy (HP:0000548)1.80328344
92Drooling (HP:0002307)1.78239845
93Decreased lacrimation (HP:0000633)1.78211853
94Lower limb amyotrophy (HP:0007210)1.77519777
95Increased density of long bones (HP:0006392)1.76328256
96Macroorchidism (HP:0000053)1.76296569
97Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.75855932
98Aortic aneurysm (HP:0004942)1.74562488
99Hypsarrhythmia (HP:0002521)1.74456438
100Anhidrosis (HP:0000970)1.74203439

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.79700684
2CAMK1G3.13938926
3CAMK1D2.62409970
4CDK122.57064034
5TAOK32.53705202
6FRK2.51691396
7OBSCN2.45944589
8SGK22.21927529
9MAP3K42.10759027
10PIK3CG2.08012339
11STK392.07723439
12NLK1.83142069
13EPHA31.76852805
14BRD41.68272271
15ZAK1.67771502
16SGK31.62180141
17SCYL21.61988139
18FER1.60872267
19MET1.57649657
20ACVR1B1.56265916
21SGK2231.49493751
22SGK4941.49493751
23CSNK1A1L1.49014000
24PIK3CA1.44857333
25LATS11.44417629
26MYLK1.40385287
27TLK11.35558442
28WNK11.34002541
29MAP4K21.30665726
30PRKAA21.30357779
31TEC1.30269061
32STK381.25090916
33MST1R1.23402035
34MAP2K71.20598098
35MST41.20546639
36BRSK21.19989356
37CAMKK21.09090291
38MAP3K21.07921210
39CSNK1G11.05844761
40PLK41.02805992
41PRKAA11.01442780
42TRPM70.97002660
43MELK0.95900726
44BMPR20.94974278
45JAK10.89711365
46CAMK40.85378510
47BMPR1B0.84871010
48FLT30.84837139
49NUAK10.83727953
50CAMK10.82123328
51NTRK30.82051854
52CSNK1G30.81494200
53STK30.80305143
54TIE10.77713554
55PHKG20.77490292
56PHKG10.77490292
57MARK20.77288640
58CASK0.75868124
59ERBB30.75604813
60DMPK0.70361154
61TNIK0.69550921
62WNK40.64099712
63SGK10.63420220
64INSRR0.60537145
65OXSR10.60505601
66CSNK1G20.60367588
67PDGFRB0.60045035
68CDK60.57599591
69MAP3K70.57407980
70PRKD30.55756546
71RPS6KA50.55177762
72NEK90.54719437
73PRKG10.54267625
74PDK10.52917435
75PRKCE0.52612543
76PTK2B0.51596283
77BMX0.48884356
78PLK20.48402557
79PINK10.46824356
80PAK30.46679600
81YES10.46240251
82PKN10.44667067
83RPS6KA30.44118388
84MAPK130.43726167
85NEK60.43512678
86STK38L0.41880719
87PIM10.41843983
88MAP2K10.41144224
89MAP3K60.40395071
90PAK20.40230251
91MAPK110.38266923
92MAPK100.38041902
93CDK30.36437402
94CSNK1D0.36048873
95PRKCB0.35846111
96MAP2K40.34482109
97VRK10.34064433
98MAPK120.33483550
99MAPKAPK50.31395932
100MAPK70.31380973

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047103.03193247
2Alcoholism_Homo sapiens_hsa050343.02143623
3Systemic lupus erythematosus_Homo sapiens_hsa053222.97089244
4Fatty acid biosynthesis_Homo sapiens_hsa000612.20517274
5Adherens junction_Homo sapiens_hsa045201.85026717
6Platelet activation_Homo sapiens_hsa046111.75838422
7Renin-angiotensin system_Homo sapiens_hsa046141.65947140
8Pancreatic secretion_Homo sapiens_hsa049721.58172731
9Sulfur metabolism_Homo sapiens_hsa009201.57062017
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.54797501
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46722397
12Fat digestion and absorption_Homo sapiens_hsa049751.41338493
13Vascular smooth muscle contraction_Homo sapiens_hsa042701.35110412
14ECM-receptor interaction_Homo sapiens_hsa045121.31496952
15Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26419801
16Renin secretion_Homo sapiens_hsa049241.24415141
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.24187207
18Salivary secretion_Homo sapiens_hsa049701.21573149
19Dilated cardiomyopathy_Homo sapiens_hsa054141.21308780
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21100128
21Thyroid cancer_Homo sapiens_hsa052161.20611529
22Serotonergic synapse_Homo sapiens_hsa047261.18051437
23Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15053451
24Insulin secretion_Homo sapiens_hsa049111.14387827
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10610841
26Gap junction_Homo sapiens_hsa045401.10012234
27Viral carcinogenesis_Homo sapiens_hsa052031.05817127
28TGF-beta signaling pathway_Homo sapiens_hsa043501.04954853
29Amphetamine addiction_Homo sapiens_hsa050311.04617578
30Arginine biosynthesis_Homo sapiens_hsa002201.03236854
31Insulin resistance_Homo sapiens_hsa049311.01857111
32Circadian entrainment_Homo sapiens_hsa047131.01055254
33Sphingolipid metabolism_Homo sapiens_hsa006001.00392754
34cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99607012
35cAMP signaling pathway_Homo sapiens_hsa040240.98395777
36Morphine addiction_Homo sapiens_hsa050320.96948041
37Linoleic acid metabolism_Homo sapiens_hsa005910.95816791
38Inositol phosphate metabolism_Homo sapiens_hsa005620.95255513
39ABC transporters_Homo sapiens_hsa020100.95108116
40Dorso-ventral axis formation_Homo sapiens_hsa043200.93345028
41Glucagon signaling pathway_Homo sapiens_hsa049220.92551382
42Lysine degradation_Homo sapiens_hsa003100.91955745
43Long-term potentiation_Homo sapiens_hsa047200.91711516
44Long-term depression_Homo sapiens_hsa047300.91417567
45Olfactory transduction_Homo sapiens_hsa047400.90052510
46Calcium signaling pathway_Homo sapiens_hsa040200.89010871
47Nicotine addiction_Homo sapiens_hsa050330.88740205
48Focal adhesion_Homo sapiens_hsa045100.88020460
49Nitrogen metabolism_Homo sapiens_hsa009100.86868333
50GABAergic synapse_Homo sapiens_hsa047270.86742986
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85468936
52Ovarian steroidogenesis_Homo sapiens_hsa049130.84911577
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83978386
54Choline metabolism in cancer_Homo sapiens_hsa052310.81116827
55Glioma_Homo sapiens_hsa052140.79704575
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79408296
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77902470
58Prostate cancer_Homo sapiens_hsa052150.77760789
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77405669
60Protein digestion and absorption_Homo sapiens_hsa049740.77193164
61Dopaminergic synapse_Homo sapiens_hsa047280.76446555
62Type II diabetes mellitus_Homo sapiens_hsa049300.76228945
63FoxO signaling pathway_Homo sapiens_hsa040680.76035984
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75565175
65Vitamin digestion and absorption_Homo sapiens_hsa049770.75397665
66Taste transduction_Homo sapiens_hsa047420.74645988
67Tight junction_Homo sapiens_hsa045300.73340818
68Glycerolipid metabolism_Homo sapiens_hsa005610.72690378
69Bile secretion_Homo sapiens_hsa049760.72274224
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72239575
71Insulin signaling pathway_Homo sapiens_hsa049100.71220303
72Prolactin signaling pathway_Homo sapiens_hsa049170.68681748
73PPAR signaling pathway_Homo sapiens_hsa033200.68084099
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67918840
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67857641
76Oxytocin signaling pathway_Homo sapiens_hsa049210.67568583
77ErbB signaling pathway_Homo sapiens_hsa040120.67148995
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.66821517
79Arachidonic acid metabolism_Homo sapiens_hsa005900.65203394
80Glutamatergic synapse_Homo sapiens_hsa047240.64918049
81Fatty acid metabolism_Homo sapiens_hsa012120.63654232
82Endometrial cancer_Homo sapiens_hsa052130.63496690
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.61821149
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60731310
85Starch and sucrose metabolism_Homo sapiens_hsa005000.59777859
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59493560
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58838349
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58683201
89Phenylalanine metabolism_Homo sapiens_hsa003600.57772625
90beta-Alanine metabolism_Homo sapiens_hsa004100.57656758
91AMPK signaling pathway_Homo sapiens_hsa041520.56891223
92Cholinergic synapse_Homo sapiens_hsa047250.54729473
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54207404
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.53262353
95Colorectal cancer_Homo sapiens_hsa052100.52710214
96Small cell lung cancer_Homo sapiens_hsa052220.52361324
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50413634
98Cocaine addiction_Homo sapiens_hsa050300.50204526
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47885160
100Fatty acid elongation_Homo sapiens_hsa000620.47654294

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