ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to Golgi (GO:0072600)	5.01089806
2	interkinetic nuclear migration (GO:0022027)	4.49290330
3	nuclear pore complex assembly (GO:0051292)	4.46930590
4	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.45406790
5	protein targeting to Golgi (GO:0000042)	4.29540001
6	negative regulation of vascular permeability (GO:0043116)	4.26360865
7	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.05849576
8	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.99908321
9	cytoplasmic mRNA processing body assembly (GO:0033962)	3.93378260
10	thrombin receptor signaling pathway (GO:0070493)	3.82053144
11	nuclear pore organization (GO:0006999)	3.71026696
12	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	3.65595775
13	positive regulation of endothelial cell differentiation (GO:0045603)	3.56900641
14	artery development (GO:0060840)	3.54341962
15	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	3.50347281
16	positive regulation of muscle hypertrophy (GO:0014742)	3.48556559
17	positive regulation of cardiac muscle hypertrophy (GO:0010613)	3.48556559
18	protein K48-linked deubiquitination (GO:0071108)	3.45735639
19	pore complex assembly (GO:0046931)	3.37347575
20	negative regulation of neurotransmitter secretion (GO:0046929)	3.35286557
21	negative regulation of protein localization to cell surface (GO:2000009)	3.32326155
22	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	3.30176905
23	regulation of lipoprotein metabolic process (GO:0050746)	3.29472093
24	carnitine shuttle (GO:0006853)	3.28216435
25	early endosome to late endosome transport (GO:0045022)	3.24324699
26	regulation of clathrin-mediated endocytosis (GO:2000369)	3.22175527
27	regulation of transforming growth factor beta2 production (GO:0032909)	3.21049422
28	sleep (GO:0030431)	3.00569792
29	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.99364671
30	keratinization (GO:0031424)	2.95956475
31	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.88827669
32	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	2.87117127
33	COPII vesicle coating (GO:0048208)	2.87107146
34	fatty acid transmembrane transport (GO:1902001)	2.87106117
35	macroautophagy (GO:0016236)	2.86564233
36	regulation of endothelial cell differentiation (GO:0045601)	2.85206752
37	microtubule nucleation (GO:0007020)	2.83928412
38	fibroblast migration (GO:0010761)	2.83914740
39	microtubule anchoring (GO:0034453)	2.83561188
40	regulation of cell communication by electrical coupling (GO:0010649)	2.83329470
41	negative regulation of neurotransmitter transport (GO:0051589)	2.82382750
42	positive regulation of glycolytic process (GO:0045821)	2.82147828
43	lymphangiogenesis (GO:0001946)	2.78553575
44	positive regulation of Rho protein signal transduction (GO:0035025)	2.78030815
45	protein localization to Golgi apparatus (GO:0034067)	2.77102970
46	long-chain fatty acid biosynthetic process (GO:0042759)	2.75664397
47	regulation of establishment of cell polarity (GO:2000114)	2.74702009
48	Golgi to plasma membrane protein transport (GO:0043001)	2.72570668
49	intra-Golgi vesicle-mediated transport (GO:0006891)	2.71059595
50	microtubule depolymerization (GO:0007019)	2.71006730
51	cyclic nucleotide catabolic process (GO:0009214)	2.68347533
52	desmosome organization (GO:0002934)	2.66529685
53	biotin metabolic process (GO:0006768)	2.63581182
54	protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)	2.63534959
55	mesodermal cell differentiation (GO:0048333)	2.61999197
56	nucleus localization (GO:0051647)	2.61455394
57	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.60684654
58	negative regulation of blood circulation (GO:1903523)	2.58124722
59	regulation of cardiac muscle hypertrophy (GO:0010611)	2.58019416
60	establishment of skin barrier (GO:0061436)	2.57457765
61	Golgi to plasma membrane transport (GO:0006893)	2.57449053
62	regulation of pigment cell differentiation (GO:0050932)	2.54221072
63	regulation of muscle hypertrophy (GO:0014743)	2.52719393
64	negative regulation of phosphoprotein phosphatase activity (GO:0032515)	2.52234282
65	regulation of female receptivity (GO:0045924)	2.52029664
66	Golgi to endosome transport (GO:0006895)	2.49532733
67	musculoskeletal movement (GO:0050881)	2.48512402
68	multicellular organismal movement (GO:0050879)	2.48512402
69	regulation of steroid hormone biosynthetic process (GO:0090030)	2.47725086
70	regulation of glycolytic process (GO:0006110)	2.45964297
71	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	2.44327624
72	regulation of relaxation of muscle (GO:1901077)	2.43367144
73	regulation of sarcomere organization (GO:0060297)	2.42383405
74	regulation of cAMP-dependent protein kinase activity (GO:2000479)	2.41900127
75	phospholipid translocation (GO:0045332)	2.41228843
76	lipid translocation (GO:0034204)	2.41228843
77	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.40701185
78	ventricular cardiac muscle cell action potential (GO:0086005)	2.39871787
79	receptor recycling (GO:0001881)	2.39724090
80	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.38919424
81	regulation of translation, ncRNA-mediated (GO:0045974)	2.38919424
82	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.38919424
83	regulation of protein localization to cell surface (GO:2000008)	2.38581636
84	carnitine transmembrane transport (GO:1902603)	2.37656513
85	linoleic acid metabolic process (GO:0043651)	2.37250823
86	regulation of energy homeostasis (GO:2000505)	2.36736005
87	regulation of NFAT protein import into nucleus (GO:0051532)	2.36439773
88	regulation of alkaline phosphatase activity (GO:0010692)	2.36431483
89	embryonic camera-type eye morphogenesis (GO:0048596)	2.34891471
90	microtubule polymerization or depolymerization (GO:0031109)	2.34849400
91	protein localization to microtubule cytoskeleton (GO:0072698)	2.34665559
92	protein K11-linked deubiquitination (GO:0035871)	2.33934988
93	cAMP catabolic process (GO:0006198)	2.31162866
94	genitalia morphogenesis (GO:0035112)	2.30602480
95	vesicle transport along microtubule (GO:0047496)	2.30330671
96	regulation of muscle adaptation (GO:0043502)	2.29597987
97	protein K63-linked deubiquitination (GO:0070536)	2.28630377
98	coronary vasculature morphogenesis (GO:0060977)	2.27433389
99	amino-acid betaine transport (GO:0015838)	2.24825973
100	carnitine transport (GO:0015879)	2.24825973

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.99756729
2	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	3.00922829
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.99776488
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.95755362
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.64196517
6	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.53384357
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.48409614
8	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.46681886
9	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.34590758
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.34291356
11	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.28461880
12	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.22893522
13	SMAD4_21799915_ChIP-Seq_A2780_Human	2.17505950
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.02317591
15	AR_21572438_ChIP-Seq_LNCaP_Human	1.97393495
16	GATA1_22025678_ChIP-Seq_K562_Human	1.92724354
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.90128647
18	STAT3_23295773_ChIP-Seq_U87_Human	1.88391601
19	P300_19829295_ChIP-Seq_ESCs_Human	1.77749459
20	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.75796543
21	AHR_22903824_ChIP-Seq_MCF-7_Human	1.68789528
22	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.65839155
23	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.65144170
24	FUS_26573619_Chip-Seq_HEK293_Human	1.64492588
25	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.63923420
26	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.63877426
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.63869210
28	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.63296692
29	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.60390293
30	TCF4_23295773_ChIP-Seq_U87_Human	1.58604323
31	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.58283000
32	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.54303892
33	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.54261470
34	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.53466456
35	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.51749811
36	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.48472797
37	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.47802880
38	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.46356001
39	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.46290005
40	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.45117959
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43980573
42	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.42201294
43	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.41489906
44	TP53_16413492_ChIP-PET_HCT116_Human	1.39627356
45	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.37463454
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.36144743
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.36144743
48	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.34420321
49	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.34251868
50	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.34113981
51	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.34113981
52	AR_25329375_ChIP-Seq_VCAP_Human	1.33823986
53	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.28574653
54	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26027812
55	CJUN_26792858_Chip-Seq_BT549_Human	1.25367208
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25203670
57	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.25125853
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23732226
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20743514
60	ER_23166858_ChIP-Seq_MCF-7_Human	1.20464189
61	CDX2_22108803_ChIP-Seq_LS180_Human	1.20376915
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19611825
63	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.19475441
64	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.18103328
65	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.18024826
66	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16588422
67	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.14620138
68	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.14114362
69	TP53_18474530_ChIP-ChIP_U2OS_Human	1.12961848
70	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12812468
71	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.12226456
72	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.11894389
73	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.10436118
74	TP63_23658742_ChIP-Seq_EP156T_Human	1.08667142
75	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.08551725
76	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08345916
77	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08069012
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07333992
79	EWS_26573619_Chip-Seq_HEK293_Human	1.06752614
80	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05210507
81	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.04042199
82	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.03542048
83	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.03138288
84	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.02633447
85	RUNX2_22187159_ChIP-Seq_PCA_Human	1.02535539
86	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.02171259
87	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01376990
88	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.01376990
89	TCF4_22108803_ChIP-Seq_LS180_Human	1.01259274
90	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.01207995
91	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.01194826
92	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.01055734
93	TBL1_22424771_ChIP-Seq_293T_Human	1.00506930
94	EZH2_22144423_ChIP-Seq_EOC_Human	1.00133525
95	RXR_22108803_ChIP-Seq_LS180_Human	0.97948403
96	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.95921829
97	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.95830368
98	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.95696952
99	VDR_22108803_ChIP-Seq_LS180_Human	0.95188908
100	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95052186

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010352_gastrointestinal_tract_polyps	3.99938704
2	MP0002009_preneoplasia	3.82924720
3	MP0008057_abnormal_DNA_replication	3.18538793
4	MP0000569_abnormal_digit_pigmentation	3.17887725
5	MP0004036_abnormal_muscle_relaxation	3.09753396
6	MP0004084_abnormal_cardiac_muscle	3.08661989
7	MP0003646_muscle_fatigue	3.08350048
8	MP0009697_abnormal_copulation	2.94326300
9	MP0000465_gastrointestinal_hemorrhage	2.61683404
10	MP0009780_abnormal_chondrocyte_physiolo	2.50623289
11	MP0004130_abnormal_muscle_cell	2.35014260
12	MP0003941_abnormal_skin_development	2.22558157
13	MP0005409_darkened_coat_color	2.22044714
14	MP0004510_myositis	2.13967275
15	MP0004233_abnormal_muscle_weight	2.12157911
16	MP0001879_abnormal_lymphatic_vessel	2.08295386
17	MP0008004_abnormal_stomach_pH	2.05209360
18	MP0005670_abnormal_white_adipose	2.02256243
19	MP0005646_abnormal_pituitary_gland	2.02224635
20	MP0004484_altered_response_of	1.86198662
21	MP0005187_abnormal_penis_morphology	1.85662365
22	MP0005083_abnormal_biliary_tract	1.81462161
23	MP0003950_abnormal_plasma_membrane	1.75917193
24	MP0000383_abnormal_hair_follicle	1.70774485
25	MP0003183_abnormal_peptide_metabolism	1.64057681
26	MP0001661_extended_life_span	1.57664864
27	MP0004134_abnormal_chest_morphology	1.56832449
28	MP0001666_abnormal_nutrient_absorption	1.56642112
29	MP0004215_abnormal_myocardial_fiber	1.55804584
30	MP0005464_abnormal_platelet_physiology	1.54049657
31	MP0010368_abnormal_lymphatic_system	1.53202766
32	MP0004264_abnormal_extraembryonic_tissu	1.53187061
33	MP0005275_abnormal_skin_tensile	1.50489468
34	MP0008775_abnormal_heart_ventricle	1.49761530
35	MP0009046_muscle_twitch	1.48460716
36	MP0006138_congestive_heart_failure	1.45931661
37	MP0005167_abnormal_blood-brain_barrier	1.45745994
38	MP0003879_abnormal_hair_cell	1.45458432
39	MP0002876_abnormal_thyroid_physiology	1.43424158
40	MP0003868_abnormal_feces_composition	1.40956140
41	MP0003045_fibrosis	1.37477841
42	MP0000013_abnormal_adipose_tissue	1.34975278
43	MP0005365_abnormal_bile_salt	1.33578545
44	MP0004270_analgesia	1.29776674
45	MP0005085_abnormal_gallbladder_physiolo	1.28013038
46	MP0004085_abnormal_heartbeat	1.27381355
47	MP0010329_abnormal_lipoprotein_level	1.27143005
48	MP0004145_abnormal_muscle_electrophysio	1.26817975
49	MP0010678_abnormal_skin_adnexa	1.20966124
50	MP0003828_pulmonary_edema	1.20163125
51	MP0009115_abnormal_fat_cell	1.20006147
52	MP0000003_abnormal_adipose_tissue	1.15417953
53	MP0000230_abnormal_systemic_arterial	1.13637409
54	MP0005620_abnormal_muscle_contractility	1.13264268
55	MP0002166_altered_tumor_susceptibility	1.12733484
56	MP0000427_abnormal_hair_cycle	1.07100291
57	MP0005410_abnormal_fertilization	1.06301625
58	MP0002332_abnormal_exercise_endurance	1.05637281
59	MP0001486_abnormal_startle_reflex	1.05360672
60	MP0002972_abnormal_cardiac_muscle	1.04235764
61	MP0003890_abnormal_embryonic-extraembry	1.04190754
62	MP0002106_abnormal_muscle_physiology	1.01977256
63	MP0003566_abnormal_cell_adhesion	1.01016668
64	MP0004924_abnormal_behavior	0.98981755
65	MP0005386_behavior/neurological_phenoty	0.98981755
66	MP0004087_abnormal_muscle_fiber	0.95181771
67	MP0003718_maternal_effect	0.93976226
68	MP0004272_abnormal_basement_membrane	0.92289488
69	MP0005666_abnormal_adipose_tissue	0.91518505
70	MP0000733_abnormal_muscle_development	0.89836603
71	MP0002971_abnormal_brown_adipose	0.89368192
72	MP0008961_abnormal_basal_metabolism	0.87845251
73	MP0001299_abnormal_eye_distance/	0.87376797
74	MP0000647_abnormal_sebaceous_gland	0.85779740
75	MP0005385_cardiovascular_system_phenoty	0.84497990
76	MP0001544_abnormal_cardiovascular_syste	0.84497990
77	MP0005375_adipose_tissue_phenotype	0.81625794
78	MP0005369_muscle_phenotype	0.78908801
79	MP0001765_abnormal_ion_homeostasis	0.75561508
80	MP0002796_impaired_skin_barrier	0.75531585
81	MP0001784_abnormal_fluid_regulation	0.75467384
82	MP0001191_abnormal_skin_condition	0.75122189
83	MP0002127_abnormal_cardiovascular_syste	0.74914510
84	MP0001501_abnormal_sleep_pattern	0.71464152
85	MP0000749_muscle_degeneration	0.71388356
86	MP0000249_abnormal_blood_vessel	0.71366569
87	MP0004147_increased_porphyrin_level	0.69100759
88	MP0002006_tumorigenesis	0.69064805
89	MP0002118_abnormal_lipid_homeostasis	0.68070749
90	MP0000759_abnormal_skeletal_muscle	0.66565316
91	MP0001851_eye_inflammation	0.66343739
92	MP0002128_abnormal_blood_circulation	0.64096261
93	MP0005266_abnormal_metabolism	0.63285542
94	MP0003633_abnormal_nervous_system	0.62485201
95	MP0010630_abnormal_cardiac_muscle	0.61472879
96	MP0003984_embryonic_growth_retardation	0.59472943
97	MP0002086_abnormal_extraembryonic_tissu	0.58920360
98	MP0005645_abnormal_hypothalamus_physiol	0.58014775
99	MP0005165_increased_susceptibility_to	0.57249065
100	MP0008877_abnormal_DNA_methylation	0.56627671

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Papillary thyroid carcinoma (HP:0002895)	5.02278908
2	Increased mean platelet volume (HP:0011877)	3.49906060
3	Nemaline bodies (HP:0003798)	3.44648578
4	Right ventricular cardiomyopathy (HP:0011663)	3.44427842
5	Menorrhagia (HP:0000132)	3.44394289
6	Tubulointerstitial nephritis (HP:0001970)	3.26981023
7	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.10096903
8	Acanthocytosis (HP:0001927)	3.06566392
9	Hyperkalemia (HP:0002153)	3.03661446
10	Papilledema (HP:0001085)	3.01204752
11	Muscle fiber inclusion bodies (HP:0100299)	3.01165608
12	Prolonged bleeding time (HP:0003010)	2.93435473
13	Petechiae (HP:0000967)	2.92673835
14	Abnormal platelet volume (HP:0011876)	2.92196357
15	Overgrowth (HP:0001548)	2.87904852
16	Thyroid carcinoma (HP:0002890)	2.69948373
17	Subaortic stenosis (HP:0001682)	2.67255007
18	Abnormality of the left ventricular outflow tract (HP:0011103)	2.67255007
19	Truncal obesity (HP:0001956)	2.67181573
20	Genetic anticipation (HP:0003743)	2.64430793
21	Bundle branch block (HP:0011710)	2.58324210
22	Abnormal auditory evoked potentials (HP:0006958)	2.57495247
23	Acute myeloid leukemia (HP:0004808)	2.57363296
24	Neonatal hypoglycemia (HP:0001998)	2.54589919
25	Insulin-resistant diabetes mellitus (HP:0000831)	2.53165698
26	Gingival bleeding (HP:0000225)	2.50918404
27	Fair hair (HP:0002286)	2.50392829
28	Renal cortical cysts (HP:0000803)	2.45470688
29	Sudden death (HP:0001699)	2.44168447
30	Medulloblastoma (HP:0002885)	2.43670229
31	Hyperventilation (HP:0002883)	2.43180208
32	Termporal pattern (HP:0011008)	2.41226523
33	Insidious onset (HP:0003587)	2.41226523
34	Hypoplastic labia majora (HP:0000059)	2.41197766
35	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.34756639
36	Abnormality of the astrocytes (HP:0100707)	2.34710554
37	Astrocytoma (HP:0009592)	2.34710554
38	Chronic hepatic failure (HP:0100626)	2.28937093
39	Hypoalphalipoproteinemia (HP:0003233)	2.26869347
40	Progressive cerebellar ataxia (HP:0002073)	2.25350495
41	Abnormality of the labia majora (HP:0012881)	2.25266853
42	Autoamputation (HP:0001218)	2.24001438
43	Facial diplegia (HP:0001349)	2.21343995
44	Abnormality of the axillary hair (HP:0100134)	2.14663538
45	Abnormality of secondary sexual hair (HP:0009888)	2.14663538
46	Gaze-evoked nystagmus (HP:0000640)	2.12980864
47	Absent eyelashes (HP:0000561)	2.12322314
48	Abnormality of the fingertips (HP:0001211)	2.11885917
49	Neoplasm of the heart (HP:0100544)	2.11269161
50	Febrile seizures (HP:0002373)	2.10232330
51	Exercise-induced myalgia (HP:0003738)	2.08529369
52	Abnormality of the renal cortex (HP:0011035)	2.07963914
53	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.06556939
54	Dysmetric saccades (HP:0000641)	2.06259564
55	Generalized hypopigmentation of hair (HP:0011358)	2.05103280
56	Conjunctival telangiectasia (HP:0000524)	2.04904042
57	Neoplasm of striated muscle (HP:0009728)	2.03810076
58	Portal hypertension (HP:0001409)	2.03032722
59	Menstrual irregularities (HP:0000858)	2.02032132
60	Abnormality of the ischium (HP:0003174)	2.01545999
61	Abnormality of potassium homeostasis (HP:0011042)	2.00053623
62	Poikilocytosis (HP:0004447)	1.96424504
63	Short chin (HP:0000331)	1.95672291
64	Urinary urgency (HP:0000012)	1.95652941
65	Abnormality of the nasal septum (HP:0000419)	1.94311024
66	Epistaxis (HP:0000421)	1.94094256
67	Broad ribs (HP:0000885)	1.94054207
68	Lip pit (HP:0100267)	1.92688834
69	Atonic seizures (HP:0010819)	1.92019965
70	Curly hair (HP:0002212)	1.91694548
71	Absent eyebrow (HP:0002223)	1.90184253
72	Ventricular tachycardia (HP:0004756)	1.88797077
73	Distal lower limb amyotrophy (HP:0008944)	1.88186024
74	Epileptiform EEG discharges (HP:0011182)	1.88172622
75	Asymmetric septal hypertrophy (HP:0001670)	1.88070615
76	Deep philtrum (HP:0002002)	1.87484443
77	Metaphyseal dysplasia (HP:0100255)	1.87284357
78	Hyporeflexia of lower limbs (HP:0002600)	1.86481590
79	Prominent nose (HP:0000448)	1.85370526
80	Submucous cleft hard palate (HP:0000176)	1.84477568
81	Osteolytic defects of the hand bones (HP:0009699)	1.83737046
82	Osteolytic defects of the phalanges of the hand (HP:0009771)	1.83737046
83	Hypolipoproteinemia (HP:0010981)	1.82717923
84	Rhabdomyosarcoma (HP:0002859)	1.82554601
85	Myoglobinuria (HP:0002913)	1.82493345
86	Urinary bladder sphincter dysfunction (HP:0002839)	1.82466344
87	Glioma (HP:0009733)	1.82232712
88	EEG with generalized epileptiform discharges (HP:0011198)	1.81784658
89	Spontaneous hematomas (HP:0007420)	1.80418719
90	Hepatoblastoma (HP:0002884)	1.80407347
91	Cone-rod dystrophy (HP:0000548)	1.80328344
92	Drooling (HP:0002307)	1.78239845
93	Decreased lacrimation (HP:0000633)	1.78211853
94	Lower limb amyotrophy (HP:0007210)	1.77519777
95	Increased density of long bones (HP:0006392)	1.76328256
96	Macroorchidism (HP:0000053)	1.76296569
97	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.75855932
98	Aortic aneurysm (HP:0004942)	1.74562488
99	Hypsarrhythmia (HP:0002521)	1.74456438
100	Anhidrosis (HP:0000970)	1.74203439

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	AKT3	4.79700684
2	CAMK1G	3.13938926
3	CAMK1D	2.62409970
4	CDK12	2.57064034
5	TAOK3	2.53705202
6	FRK	2.51691396
7	OBSCN	2.45944589
8	SGK2	2.21927529
9	MAP3K4	2.10759027
10	PIK3CG	2.08012339
11	STK39	2.07723439
12	NLK	1.83142069
13	EPHA3	1.76852805
14	BRD4	1.68272271
15	ZAK	1.67771502
16	SGK3	1.62180141
17	SCYL2	1.61988139
18	FER	1.60872267
19	MET	1.57649657
20	ACVR1B	1.56265916
21	SGK223	1.49493751
22	SGK494	1.49493751
23	CSNK1A1L	1.49014000
24	PIK3CA	1.44857333
25	LATS1	1.44417629
26	MYLK	1.40385287
27	TLK1	1.35558442
28	WNK1	1.34002541
29	MAP4K2	1.30665726
30	PRKAA2	1.30357779
31	TEC	1.30269061
32	STK38	1.25090916
33	MST1R	1.23402035
34	MAP2K7	1.20598098
35	MST4	1.20546639
36	BRSK2	1.19989356
37	CAMKK2	1.09090291
38	MAP3K2	1.07921210
39	CSNK1G1	1.05844761
40	PLK4	1.02805992
41	PRKAA1	1.01442780
42	TRPM7	0.97002660
43	MELK	0.95900726
44	BMPR2	0.94974278
45	JAK1	0.89711365
46	CAMK4	0.85378510
47	BMPR1B	0.84871010
48	FLT3	0.84837139
49	NUAK1	0.83727953
50	CAMK1	0.82123328
51	NTRK3	0.82051854
52	CSNK1G3	0.81494200
53	STK3	0.80305143
54	TIE1	0.77713554
55	PHKG2	0.77490292
56	PHKG1	0.77490292
57	MARK2	0.77288640
58	CASK	0.75868124
59	ERBB3	0.75604813
60	DMPK	0.70361154
61	TNIK	0.69550921
62	WNK4	0.64099712
63	SGK1	0.63420220
64	INSRR	0.60537145
65	OXSR1	0.60505601
66	CSNK1G2	0.60367588
67	PDGFRB	0.60045035
68	CDK6	0.57599591
69	MAP3K7	0.57407980
70	PRKD3	0.55756546
71	RPS6KA5	0.55177762
72	NEK9	0.54719437
73	PRKG1	0.54267625
74	PDK1	0.52917435
75	PRKCE	0.52612543
76	PTK2B	0.51596283
77	BMX	0.48884356
78	PLK2	0.48402557
79	PINK1	0.46824356
80	PAK3	0.46679600
81	YES1	0.46240251
82	PKN1	0.44667067
83	RPS6KA3	0.44118388
84	MAPK13	0.43726167
85	NEK6	0.43512678
86	STK38L	0.41880719
87	PIM1	0.41843983
88	MAP2K1	0.41144224
89	MAP3K6	0.40395071
90	PAK2	0.40230251
91	MAPK11	0.38266923
92	MAPK10	0.38041902
93	CDK3	0.36437402
94	CSNK1D	0.36048873
95	PRKCB	0.35846111
96	MAP2K4	0.34482109
97	VRK1	0.34064433
98	MAPK12	0.33483550
99	MAPKAPK5	0.31395932
100	MAPK7	0.31380973

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Circadian rhythm_Homo sapiens_hsa04710	3.03193247
2	Alcoholism_Homo sapiens_hsa05034	3.02143623
3	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.97089244
4	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.20517274
5	Adherens junction_Homo sapiens_hsa04520	1.85026717
6	Platelet activation_Homo sapiens_hsa04611	1.75838422
7	Renin-angiotensin system_Homo sapiens_hsa04614	1.65947140
8	Pancreatic secretion_Homo sapiens_hsa04972	1.58172731
9	Sulfur metabolism_Homo sapiens_hsa00920	1.57062017
10	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.54797501
11	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.46722397
12	Fat digestion and absorption_Homo sapiens_hsa04975	1.41338493
13	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.35110412
14	ECM-receptor interaction_Homo sapiens_hsa04512	1.31496952
15	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.26419801
16	Renin secretion_Homo sapiens_hsa04924	1.24415141
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.24187207
18	Salivary secretion_Homo sapiens_hsa04970	1.21573149
19	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.21308780
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.21100128
21	Thyroid cancer_Homo sapiens_hsa05216	1.20611529
22	Serotonergic synapse_Homo sapiens_hsa04726	1.18051437
23	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.15053451
24	Insulin secretion_Homo sapiens_hsa04911	1.14387827
25	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.10610841
26	Gap junction_Homo sapiens_hsa04540	1.10012234
27	Viral carcinogenesis_Homo sapiens_hsa05203	1.05817127
28	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.04954853
29	Amphetamine addiction_Homo sapiens_hsa05031	1.04617578
30	Arginine biosynthesis_Homo sapiens_hsa00220	1.03236854
31	Insulin resistance_Homo sapiens_hsa04931	1.01857111
32	Circadian entrainment_Homo sapiens_hsa04713	1.01055254
33	Sphingolipid metabolism_Homo sapiens_hsa00600	1.00392754
34	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.99607012
35	cAMP signaling pathway_Homo sapiens_hsa04024	0.98395777
36	Morphine addiction_Homo sapiens_hsa05032	0.96948041
37	Linoleic acid metabolism_Homo sapiens_hsa00591	0.95816791
38	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.95255513
39	ABC transporters_Homo sapiens_hsa02010	0.95108116
40	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.93345028
41	Glucagon signaling pathway_Homo sapiens_hsa04922	0.92551382
42	Lysine degradation_Homo sapiens_hsa00310	0.91955745
43	Long-term potentiation_Homo sapiens_hsa04720	0.91711516
44	Long-term depression_Homo sapiens_hsa04730	0.91417567
45	Olfactory transduction_Homo sapiens_hsa04740	0.90052510
46	Calcium signaling pathway_Homo sapiens_hsa04020	0.89010871
47	Nicotine addiction_Homo sapiens_hsa05033	0.88740205
48	Focal adhesion_Homo sapiens_hsa04510	0.88020460
49	Nitrogen metabolism_Homo sapiens_hsa00910	0.86868333
50	GABAergic synapse_Homo sapiens_hsa04727	0.86742986
51	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.85468936
52	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.84911577
53	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.83978386
54	Choline metabolism in cancer_Homo sapiens_hsa05231	0.81116827
55	Glioma_Homo sapiens_hsa05214	0.79704575
56	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.79408296
57	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.77902470
58	Prostate cancer_Homo sapiens_hsa05215	0.77760789
59	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.77405669
60	Protein digestion and absorption_Homo sapiens_hsa04974	0.77193164
61	Dopaminergic synapse_Homo sapiens_hsa04728	0.76446555
62	Type II diabetes mellitus_Homo sapiens_hsa04930	0.76228945
63	FoxO signaling pathway_Homo sapiens_hsa04068	0.76035984
64	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.75565175
65	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.75397665
66	Taste transduction_Homo sapiens_hsa04742	0.74645988
67	Tight junction_Homo sapiens_hsa04530	0.73340818
68	Glycerolipid metabolism_Homo sapiens_hsa00561	0.72690378
69	Bile secretion_Homo sapiens_hsa04976	0.72274224
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.72239575
71	Insulin signaling pathway_Homo sapiens_hsa04910	0.71220303
72	Prolactin signaling pathway_Homo sapiens_hsa04917	0.68681748
73	PPAR signaling pathway_Homo sapiens_hsa03320	0.68084099
74	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.67918840
75	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.67857641
76	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.67568583
77	ErbB signaling pathway_Homo sapiens_hsa04012	0.67148995
78	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.66821517
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.65203394
80	Glutamatergic synapse_Homo sapiens_hsa04724	0.64918049
81	Fatty acid metabolism_Homo sapiens_hsa01212	0.63654232
82	Endometrial cancer_Homo sapiens_hsa05213	0.63496690
83	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.61821149
84	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.60731310
85	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.59777859
86	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.59493560
87	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.58838349
88	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58683201
89	Phenylalanine metabolism_Homo sapiens_hsa00360	0.57772625
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57656758
91	AMPK signaling pathway_Homo sapiens_hsa04152	0.56891223
92	Cholinergic synapse_Homo sapiens_hsa04725	0.54729473
93	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.54207404
94	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.53262353
95	Colorectal cancer_Homo sapiens_hsa05210	0.52710214
96	Small cell lung cancer_Homo sapiens_hsa05222	0.52361324
97	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.50413634
98	Cocaine addiction_Homo sapiens_hsa05030	0.50204526
99	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.47885160
100	Fatty acid elongation_Homo sapiens_hsa00062	0.47654294

MTRNR2L6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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