ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	4.97653905
2	fusion of sperm to egg plasma membrane (GO:0007342)	4.75332597
3	cell adhesion mediated by integrin (GO:0033627)	4.41594548
4	sperm motility (GO:0030317)	4.25698704
5	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.06797271
6	L-phenylalanine metabolic process (GO:0006558)	4.06797271
7	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.99713425
8	L-phenylalanine catabolic process (GO:0006559)	3.99713425
9	rRNA methylation (GO:0031167)	3.91950051
10	sperm-egg recognition (GO:0035036)	3.88923272
11	GTP biosynthetic process (GO:0006183)	3.85512987
12	single strand break repair (GO:0000012)	3.80149059
13	positive regulation of cellular response to oxidative stress (GO:1900409)	3.78039262
14	positive regulation of response to oxidative stress (GO:1902884)	3.78039262
15	acrosome reaction (GO:0007340)	3.72630000
16	response to pheromone (GO:0019236)	3.68038967
17	plasma membrane fusion (GO:0045026)	3.65828383
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.64415735
19	NADH dehydrogenase complex assembly (GO:0010257)	3.64415735
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.64415735
21	binding of sperm to zona pellucida (GO:0007339)	3.62106917
22	rRNA modification (GO:0000154)	3.55713610
23	regulation of bile acid biosynthetic process (GO:0070857)	3.55022356
24	dicarboxylic acid biosynthetic process (GO:0043650)	3.50935932
25	water-soluble vitamin biosynthetic process (GO:0042364)	3.49535374
26	protein polyglutamylation (GO:0018095)	3.48054451
27	DNA replication-dependent nucleosome organization (GO:0034723)	3.47763018
28	DNA replication-dependent nucleosome assembly (GO:0006335)	3.47763018
29	arginine metabolic process (GO:0006525)	3.42922279
30	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	3.34329752
31	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	3.34102879
32	xenobiotic catabolic process (GO:0042178)	3.33176846
33	microtubule depolymerization (GO:0007019)	3.28215208
34	detection of light stimulus involved in visual perception (GO:0050908)	3.24505943
35	detection of light stimulus involved in sensory perception (GO:0050962)	3.24505943
36	positive regulation of endothelial cell differentiation (GO:0045603)	3.23378888
37	UTP biosynthetic process (GO:0006228)	3.19444030
38	primary amino compound metabolic process (GO:1901160)	3.17349950
39	dicarboxylic acid catabolic process (GO:0043649)	3.14268962
40	peptidyl-glutamic acid modification (GO:0018200)	3.13977042
41	glycerophospholipid catabolic process (GO:0046475)	3.13003479
42	multicellular organism reproduction (GO:0032504)	3.12005678
43	ER overload response (GO:0006983)	3.09975047
44	low-density lipoprotein particle remodeling (GO:0034374)	3.08593919
45	UTP metabolic process (GO:0046051)	3.07045409
46	regulation of cilium movement (GO:0003352)	3.05144239
47	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.97961757
48	DNA deamination (GO:0045006)	2.97582912
49	cell-cell recognition (GO:0009988)	2.93732853
50	C4-dicarboxylate transport (GO:0015740)	2.93273701
51	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.91950614
52	retina homeostasis (GO:0001895)	2.87134315
53	glycerol ether metabolic process (GO:0006662)	2.84739202
54	protein complex biogenesis (GO:0070271)	2.81994487
55	innate immune response in mucosa (GO:0002227)	2.81365177
56	negative regulation of mast cell activation (GO:0033004)	2.78686308
57	proteasome assembly (GO:0043248)	2.77694077
58	translesion synthesis (GO:0019985)	2.77571634
59	aromatic amino acid family catabolic process (GO:0009074)	2.76293663
60	mannosylation (GO:0097502)	2.74577900
61	arginine catabolic process (GO:0006527)	2.74387683
62	adenosine metabolic process (GO:0046085)	2.74077260
63	glutathione derivative metabolic process (GO:1901685)	2.71555854
64	glutathione derivative biosynthetic process (GO:1901687)	2.71555854
65	ether metabolic process (GO:0018904)	2.71472309
66	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.71181099
67	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.70974616
68	establishment of protein localization to Golgi (GO:0072600)	2.69879688
69	protein targeting to Golgi (GO:0000042)	2.68277276
70	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.64762655
71	ATP synthesis coupled proton transport (GO:0015986)	2.64762655
72	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.64119820
73	meiosis I (GO:0007127)	2.62164972
74	regulation of glucokinase activity (GO:0033131)	2.62011418
75	regulation of hexokinase activity (GO:1903299)	2.62011418
76	DNA double-strand break processing (GO:0000729)	2.61315723
77	male meiosis I (GO:0007141)	2.61256380
78	mitochondrial respiratory chain complex assembly (GO:0033108)	2.59525807
79	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.57293919
80	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.54917865
81	nucleoside diphosphate phosphorylation (GO:0006165)	2.52376784
82	replicative senescence (GO:0090399)	2.51878888
83	tyrosine metabolic process (GO:0006570)	2.50963104
84	cellular response to arsenic-containing substance (GO:0071243)	2.48683399
85	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.48218017
86	regulation of hydrogen peroxide metabolic process (GO:0010310)	2.47249831
87	preassembly of GPI anchor in ER membrane (GO:0016254)	2.47137865
88	mucosal immune response (GO:0002385)	2.45730789
89	pseudouridine synthesis (GO:0001522)	2.44514563
90	protein K6-linked ubiquitination (GO:0085020)	2.44095146
91	CTP biosynthetic process (GO:0006241)	2.41720260
92	CTP metabolic process (GO:0046036)	2.41720260
93	regulation of transmission of nerve impulse (GO:0051969)	2.40721589
94	peptidyl-glutamic acid carboxylation (GO:0017187)	2.39619529
95	protein carboxylation (GO:0018214)	2.39619529
96	cofactor catabolic process (GO:0051187)	2.39284272
97	regulation of response to tumor cell (GO:0002834)	2.39065507
98	positive regulation of response to tumor cell (GO:0002836)	2.39065507
99	positive regulation of immune response to tumor cell (GO:0002839)	2.39065507
100	regulation of immune response to tumor cell (GO:0002837)	2.39065507

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.99247428
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.98142479
3	VDR_22108803_ChIP-Seq_LS180_Human	2.94912906
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.79834857
5	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	2.61622488
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.52455528
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.23257657
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.21248505
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.12041415
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	10.6136069
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.99214351
12	IRF1_19129219_ChIP-ChIP_H3396_Human	1.96659014
13	GBX2_23144817_ChIP-Seq_PC3_Human	1.91866534
14	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.79354671
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.77206993
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.76594768
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.73964201
18	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.68946775
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64240335
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.62981636
21	P300_19829295_ChIP-Seq_ESCs_Human	1.59655574
22	EZH2_22144423_ChIP-Seq_EOC_Human	1.54786544
23	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.50434893
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.47818431
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.47307639
26	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47307639
27	EWS_26573619_Chip-Seq_HEK293_Human	1.47217415
28	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.41873641
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.41679551
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40220351
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.40163176
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.37338443
33	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.34573601
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.33652286
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33336281
36	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.26104458
37	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.25805435
38	ERG_20517297_ChIP-Seq_VCAP_Human	1.23412534
39	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.22565240
40	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.21578974
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.20689229
42	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20466404
43	VDR_23849224_ChIP-Seq_CD4+_Human	1.20454756
44	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.18542287
45	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.18518525
46	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.18223085
47	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.17855689
48	FUS_26573619_Chip-Seq_HEK293_Human	1.17575706
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14714194
50	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.13778671
51	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.12546982
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11803803
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11803803
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.11776514
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10303400
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10303400
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.09806955
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.09534166
59	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.07993160
60	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07013824
61	ER_23166858_ChIP-Seq_MCF-7_Human	1.06904325
62	AR_25329375_ChIP-Seq_VCAP_Human	1.03958061
63	SMAD4_21799915_ChIP-Seq_A2780_Human	1.03760048
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03480924
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02052823
66	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.01696790
67	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.01582919
68	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.00727568
69	PHF8_20622853_ChIP-Seq_HELA_Human	0.99467354
70	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.99292929
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98388912
72	NCOR_22424771_ChIP-Seq_293T_Human	0.98209617
73	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.96450076
74	HTT_18923047_ChIP-ChIP_STHdh_Human	0.96443128
75	AR_20517297_ChIP-Seq_VCAP_Human	0.96165603
76	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.96080214
77	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.95721781
78	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.94149109
79	NANOG_20526341_ChIP-Seq_ESCs_Human	0.93731174
80	TCF4_22108803_ChIP-Seq_LS180_Human	0.93571546
81	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.93343322
82	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.92268920
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.91701722
84	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.91349034
85	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.90559800
86	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.90348710
87	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.89869880
88	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.88700325
89	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.87830136
90	ERA_21632823_ChIP-Seq_H3396_Human	0.87813353
91	FOXP3_21729870_ChIP-Seq_TREG_Human	0.86661005
92	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.86437196
93	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.86300461
94	NFYB_21822215_ChIP-Seq_K562_Human	0.85658825
95	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.85265664
96	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.84626032
97	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.84534579
98	RBPJ_21746931_ChIP-Seq_IB4_Human	0.84459468
99	TAF2_19829295_ChIP-Seq_ESCs_Human	0.84181320
100	ETV1_20927104_ChIP-Seq_GIST48_Human	0.83596108

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	4.53283569
2	MP0003950_abnormal_plasma_membrane	3.13146932
3	MP0006054_spinal_hemorrhage	3.02865536
4	MP0008875_abnormal_xenobiotic_pharmacok	2.93427103
5	MP0005360_urolithiasis	2.77668827
6	MP0003195_calcinosis	2.73950492
7	MP0009697_abnormal_copulation	2.56772528
8	MP0005365_abnormal_bile_salt	2.32427786
9	MP0005187_abnormal_penis_morphology	2.24862896
10	MP0002736_abnormal_nociception_after	2.11985109
11	MP0005167_abnormal_blood-brain_barrier	2.10481779
12	MP0005464_abnormal_platelet_physiology	2.08417101
13	MP0008004_abnormal_stomach_pH	2.05415775
14	MP0009780_abnormal_chondrocyte_physiolo	2.02402241
15	MP0003718_maternal_effect	1.99232066
16	MP0005646_abnormal_pituitary_gland	1.98915714
17	MP0002102_abnormal_ear_morphology	1.97532983
18	MP0010386_abnormal_urinary_bladder	1.87316863
19	MP0008872_abnormal_physiological_respon	1.83694513
20	MP0001905_abnormal_dopamine_level	1.73401371
21	MP0003252_abnormal_bile_duct	1.69420713
22	MP0005551_abnormal_eye_electrophysiolog	1.68173443
23	MP0005085_abnormal_gallbladder_physiolo	1.67644370
24	MP0005084_abnormal_gallbladder_morpholo	1.65752035
25	MP0002139_abnormal_hepatobiliary_system	1.65448418
26	MP0001968_abnormal_touch/_nociception	1.60802375
27	MP0004043_abnormal_pH_regulation	1.56714066
28	MP0004272_abnormal_basement_membrane	1.49049231
29	MP0005253_abnormal_eye_physiology	1.48060015
30	MP0003698_abnormal_male_reproductive	1.46781992
31	MP0006072_abnormal_retinal_apoptosis	1.45731162
32	MP0010329_abnormal_lipoprotein_level	1.44444406
33	MP0001929_abnormal_gametogenesis	1.44371620
34	MP0006292_abnormal_olfactory_placode	1.41325290
35	MP0004084_abnormal_cardiac_muscle	1.40147198
36	MP0002160_abnormal_reproductive_system	1.37319864
37	MP0002735_abnormal_chemical_nociception	1.35111901
38	MP0001485_abnormal_pinna_reflex	1.31768723
39	MP0003119_abnormal_digestive_system	1.27985221
40	MP0001919_abnormal_reproductive_system	1.23483306
41	MP0003186_abnormal_redox_activity	1.21948706
42	MP0005377_hearing/vestibular/ear_phenot	1.20996775
43	MP0003878_abnormal_ear_physiology	1.20996775
44	MP0005389_reproductive_system_phenotype	1.20749873
45	MP0006276_abnormal_autonomic_nervous	1.20448270
46	MP0005623_abnormal_meninges_morphology	1.19731427
47	MP0005423_abnormal_somatic_nervous	1.18429360
48	MP0001764_abnormal_homeostasis	1.17278906
49	MP0000647_abnormal_sebaceous_gland	1.16014101
50	MP0001765_abnormal_ion_homeostasis	1.13677758
51	MP0005645_abnormal_hypothalamus_physiol	1.11708968
52	MP0001529_abnormal_vocalization	1.11556888
53	MP0005248_abnormal_Harderian_gland	1.11212076
54	MP0008438_abnormal_cutaneous_collagen	1.09027372
55	MP0002295_abnormal_pulmonary_circulatio	1.07117758
56	MP0004142_abnormal_muscle_tone	1.06988582
57	MP0000230_abnormal_systemic_arterial	1.06481072
58	MP0009053_abnormal_anal_canal	1.05931807
59	MP0003693_abnormal_embryo_hatching	1.05337517
60	MP0004036_abnormal_muscle_relaxation	1.04752745
61	MP0001661_extended_life_span	1.03788094
62	MP0005332_abnormal_amino_acid	1.03476414
63	MP0008877_abnormal_DNA_methylation	1.02917969
64	MP0005636_abnormal_mineral_homeostasis	1.00493164
65	MP0002733_abnormal_thermal_nociception	0.99303060
66	MP0002557_abnormal_social/conspecific_i	0.98223186
67	MP0008058_abnormal_DNA_repair	0.95094968
68	MP0002090_abnormal_vision	0.94917946
69	MP0003646_muscle_fatigue	0.93974049
70	MP0002161_abnormal_fertility/fecundity	0.90820156
71	MP0001502_abnormal_circadian_rhythm	0.90522642
72	MP0000653_abnormal_sex_gland	0.89608539
73	MP0002272_abnormal_nervous_system	0.89018673
74	MP0002210_abnormal_sex_determination	0.88928946
75	MP0000372_irregular_coat_pigmentation	0.88197923
76	MP0005220_abnormal_exocrine_pancreas	0.87614788
77	MP0002938_white_spotting	0.85633567
78	MP0005670_abnormal_white_adipose	0.84536341
79	MP0002138_abnormal_hepatobiliary_system	0.84459388
80	MP0000465_gastrointestinal_hemorrhage	0.83983762
81	MP0004957_abnormal_blastocyst_morpholog	0.81754357
82	MP0010094_abnormal_chromosome_stability	0.81672767
83	MP0008775_abnormal_heart_ventricle	0.81507026
84	MP0004133_heterotaxia	0.81001637
85	MP0002693_abnormal_pancreas_physiology	0.80608726
86	MP0002653_abnormal_ependyma_morphology	0.79428353
87	MP0005083_abnormal_biliary_tract	0.78687915
88	MP0005319_abnormal_enzyme/_coenzyme	0.78407812
89	MP0009840_abnormal_foam_cell	0.77607039
90	MP0001963_abnormal_hearing_physiology	0.74940323
91	MP0001348_abnormal_lacrimal_gland	0.73637779
92	MP0002229_neurodegeneration	0.71902997
93	MP0009745_abnormal_behavioral_response	0.71810653
94	MP0009046_muscle_twitch	0.71158669
95	MP0001440_abnormal_grooming_behavior	0.70900394
96	MP0009643_abnormal_urine_homeostasis	0.69894513
97	MP0000631_abnormal_neuroendocrine_gland	0.69881371
98	MP0005195_abnormal_posterior_eye	0.69103168
99	MP0001145_abnormal_male_reproductive	0.68949389
100	MP0001915_intracranial_hemorrhage	0.68536658

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Nuclear cataract (HP:0100018)	4.30021139
2	Acute necrotizing encephalopathy (HP:0006965)	4.07731187
3	Acute encephalopathy (HP:0006846)	3.68619105
4	Petechiae (HP:0000967)	3.62735445
5	Vascular calcification (HP:0004934)	3.50799283
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.43295549
7	Hypophosphatemic rickets (HP:0004912)	3.41693888
8	Progressive macrocephaly (HP:0004481)	3.33532289
9	Cardiovascular calcification (HP:0011915)	3.08462581
10	Mitochondrial inheritance (HP:0001427)	3.06768236
11	Renal Fanconi syndrome (HP:0001994)	3.06462947
12	Generalized aminoaciduria (HP:0002909)	3.02411787
13	Increased CSF lactate (HP:0002490)	2.97420965
14	Decreased circulating renin level (HP:0003351)	2.91532175
15	Decreased central vision (HP:0007663)	2.87718059
16	Menorrhagia (HP:0000132)	2.84148283
17	Abnormality of alanine metabolism (HP:0010916)	2.83842594
18	Hyperalaninemia (HP:0003348)	2.83842594
19	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.83842594
20	Back pain (HP:0003418)	2.81591988
21	Cerebral edema (HP:0002181)	2.81262038
22	Severe visual impairment (HP:0001141)	2.79609698
23	Hypoglycemic coma (HP:0001325)	2.78863895
24	Acanthocytosis (HP:0001927)	2.61208674
25	Lipid accumulation in hepatocytes (HP:0006561)	2.60316336
26	Intrahepatic cholestasis (HP:0001406)	2.55428955
27	Hyperglycinemia (HP:0002154)	2.53516966
28	Prolonged bleeding time (HP:0003010)	2.49729716
29	Purpura (HP:0000979)	2.43861558
30	Hypoalphalipoproteinemia (HP:0003233)	2.42131502
31	Vacuolated lymphocytes (HP:0001922)	2.42111304
32	Abnormality of methionine metabolism (HP:0010901)	2.40174728
33	Abolished electroretinogram (ERG) (HP:0000550)	2.37913181
34	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.36207810
35	Abnormality of urine glucose concentration (HP:0011016)	2.35181383
36	Glycosuria (HP:0003076)	2.35181383
37	Increased hepatocellular lipid droplets (HP:0006565)	2.33919785
38	Renal cortical cysts (HP:0000803)	2.30493686
39	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.30381256
40	Absent/shortened dynein arms (HP:0200106)	2.30381256
41	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.30287734
42	Abnormality of macular pigmentation (HP:0008002)	2.30205035
43	Hepatic necrosis (HP:0002605)	2.28948418
44	Degeneration of anterior horn cells (HP:0002398)	2.27459213
45	Abnormality of the anterior horn cell (HP:0006802)	2.27459213
46	Pancreatic islet-cell hyperplasia (HP:0004510)	2.26247195
47	Abnormality of the renal cortex (HP:0011035)	2.25929273
48	Attenuation of retinal blood vessels (HP:0007843)	2.22501334
49	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.22016058
50	Chronic bronchitis (HP:0004469)	2.19844774
51	Febrile seizures (HP:0002373)	2.18632244
52	Abnormal pupillary function (HP:0007686)	2.14479679
53	Hypolipoproteinemia (HP:0010981)	2.14187542
54	Hydroxyprolinuria (HP:0003080)	2.10508901
55	Abnormality of proline metabolism (HP:0010907)	2.10508901
56	Bony spicule pigmentary retinopathy (HP:0007737)	2.09636976
57	Hepatocellular carcinoma (HP:0001402)	2.09318119
58	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.08305419
59	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.08054460
60	Hypokalemic alkalosis (HP:0001949)	2.07521604
61	Mitral stenosis (HP:0001718)	2.07384630
62	Zonular cataract (HP:0010920)	2.06221233
63	Abnormality of serum amino acid levels (HP:0003112)	2.05297859
64	Optic disc pallor (HP:0000543)	2.05240242
65	Respiratory failure (HP:0002878)	2.02342758
66	Xanthomatosis (HP:0000991)	2.01143436
67	Abnormal rod and cone electroretinograms (HP:0008323)	1.98815671
68	Bicornuate uterus (HP:0000813)	1.98646862
69	J-shaped sella turcica (HP:0002680)	1.97182256
70	Constricted visual fields (HP:0001133)	1.97085725
71	Congenital stationary night blindness (HP:0007642)	1.97048870
72	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.93280309
73	Nephronophthisis (HP:0000090)	1.91878706
74	Hyperlipoproteinemia (HP:0010980)	1.91872475
75	Hyperactive renin-angiotensin system (HP:0000841)	1.90738434
76	Poikilocytosis (HP:0004447)	1.90382396
77	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.88368153
78	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.88099184
79	Cone-rod dystrophy (HP:0000548)	1.87288007
80	Abnormality of renal resorption (HP:0011038)	1.86820713
81	Increased mean platelet volume (HP:0011877)	1.86627350
82	Short 1st metacarpal (HP:0010034)	1.84273678
83	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.84273678
84	Leukodystrophy (HP:0002415)	1.83660053
85	Hypoplasia of the fovea (HP:0007750)	1.83335303
86	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.83335303
87	Rickets (HP:0002748)	1.83098595
88	Pancreatic fibrosis (HP:0100732)	1.83097265
89	Nausea (HP:0002018)	1.82260301
90	Hepatocellular necrosis (HP:0001404)	1.80136645
91	Abnormality of dental color (HP:0011073)	1.79353790
92	Pancreatic cysts (HP:0001737)	1.78986893
93	Overlapping toe (HP:0001845)	1.76518630
94	Prolonged neonatal jaundice (HP:0006579)	1.75135241
95	Abnormality of the renal medulla (HP:0100957)	1.75117026
96	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.73446284
97	Absent epiphyses (HP:0010577)	1.73446284
98	Confusion (HP:0001289)	1.72241897
99	Hyperkalemia (HP:0002153)	1.71118591
100	Lactic acidosis (HP:0003128)	1.70954666

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	5.86802269
2	TLK1	5.60562747
3	VRK1	2.84329463
4	TAOK3	2.79974006
5	MAP3K9	2.50753396
6	PIK3CG	2.40838315
7	NUAK1	2.36980657
8	TAF1	2.20542060
9	VRK2	1.85059493
10	PBK	1.81728636
11	BUB1	1.77493848
12	FRK	1.73207033
13	WNK4	1.67678620
14	MST4	1.57297978
15	ADRBK2	1.57252638
16	STK39	1.55436591
17	TNIK	1.53259195
18	CSNK1G3	1.52339322
19	PLK2	1.46542270
20	BMPR1B	1.46328923
21	MAP4K2	1.45431848
22	CASK	1.40919940
23	AURKA	1.39566991
24	GRK1	1.38662790
25	CSNK1A1L	1.31704539
26	CSNK1G1	1.30418827
27	RPS6KA5	1.29478212
28	PLK4	1.22636597
29	INSRR	1.22590695
30	CSNK1G2	1.21760587
31	MARK1	1.21120863
32	CAMK1G	1.16084009
33	STK16	1.13119803
34	MAPKAPK3	1.10330406
35	DAPK3	1.08372505
36	CDK9	1.07829778
37	STK4	1.07355152
38	MYLK	1.06476782
39	FER	1.02810795
40	AKT3	1.01112176
41	WNK3	1.00165599
42	PNCK	0.89539261
43	PINK1	0.88636741
44	CCNB1	0.88294518
45	ACVR1B	0.83874702
46	TSSK6	0.81986574
47	CAMK1D	0.80833182
48	MAPKAPK5	0.80200216
49	GRK5	0.80043881
50	SMG1	0.79637156
51	CHEK2	0.75216983
52	PHKG1	0.74971607
53	PHKG2	0.74971607
54	PRKCG	0.73408789
55	ERBB2	0.70402917
56	LMTK2	0.66970710
57	AURKB	0.66033583
58	TEC	0.65672701
59	OXSR1	0.65235699
60	MOS	0.63554688
61	PLK3	0.63082581
62	CDC7	0.60964888
63	BRAF	0.60792138
64	PDK2	0.59873562
65	ARAF	0.58919252
66	STK38L	0.58554666
67	AKT2	0.56108580
68	PRKAA1	0.54548618
69	IKBKB	0.53117029
70	PLK1	0.51152931
71	PAK1	0.50148725
72	TESK1	0.47393451
73	DYRK2	0.42826871
74	PRKCE	0.40597366
75	PKN1	0.39550178
76	CHUK	0.38319796
77	CAMK4	0.36857032
78	ATR	0.36656897
79	PRKG1	0.36518577
80	PRKCB	0.36165088
81	CAMK2A	0.35095252
82	PAK3	0.34921659
83	PTK2B	0.34576333
84	CSNK1E	0.33706096
85	EIF2AK1	0.33678007
86	EIF2AK2	0.31935123
87	PRKCA	0.31072913
88	PRKACA	0.30491476
89	CSNK1A1	0.30257974
90	CSNK1D	0.30046724
91	MAP2K2	0.29323163
92	SGK2	0.29272883
93	ADRBK1	0.28194020
94	PRKAA2	0.28011920
95	GRK7	0.27943584
96	PRKCD	0.27898554
97	PRKACG	0.27712232
98	EIF2AK3	0.27703760
99	CHEK1	0.27033874
100	MKNK2	0.27029215

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	4.97790716
2	Alcoholism_Homo sapiens_hsa05034	3.76864612
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.96811679
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.88311279
5	Sulfur metabolism_Homo sapiens_hsa00920	2.75908394
6	Proteasome_Homo sapiens_hsa03050	2.47020646
7	Protein export_Homo sapiens_hsa03060	2.18433198
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.15233111
9	Arginine biosynthesis_Homo sapiens_hsa00220	1.98303061
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.93190589
11	Parkinsons disease_Homo sapiens_hsa05012	1.64869993
12	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.63254234
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.60007640
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.56841651
15	Fatty acid elongation_Homo sapiens_hsa00062	1.43810625
16	Glutathione metabolism_Homo sapiens_hsa00480	1.39233673
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.38652564
18	Steroid biosynthesis_Homo sapiens_hsa00100	1.37876452
19	Huntingtons disease_Homo sapiens_hsa05016	1.34842359
20	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.33467132
21	Fat digestion and absorption_Homo sapiens_hsa04975	1.29596491
22	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.27817188
23	Peroxisome_Homo sapiens_hsa04146	1.25534283
24	RNA polymerase_Homo sapiens_hsa03020	1.23743053
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.23250042
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.22187060
27	Butanoate metabolism_Homo sapiens_hsa00650	1.21641624
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.20567184
29	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.19637567
30	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.19574505
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.18371631
32	Arginine and proline metabolism_Homo sapiens_hsa00330	1.17636578
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.17077506
34	Basal transcription factors_Homo sapiens_hsa03022	1.16411958
35	Alzheimers disease_Homo sapiens_hsa05010	1.14753976
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.13939517
37	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.13406359
38	Fatty acid degradation_Homo sapiens_hsa00071	1.12293219
39	Viral carcinogenesis_Homo sapiens_hsa05203	1.11304023
40	Caffeine metabolism_Homo sapiens_hsa00232	1.07287960
41	Collecting duct acid secretion_Homo sapiens_hsa04966	1.05530093
42	Linoleic acid metabolism_Homo sapiens_hsa00591	1.03431954
43	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.03049829
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.02859095
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.02662526
46	Sulfur relay system_Homo sapiens_hsa04122	1.00283595
47	Fatty acid metabolism_Homo sapiens_hsa01212	0.98173980
48	Homologous recombination_Homo sapiens_hsa03440	0.96983205
49	One carbon pool by folate_Homo sapiens_hsa00670	0.95190569
50	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.93970030
51	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.93738622
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.93598684
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.93195041
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.90373863
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.88113815
56	Mismatch repair_Homo sapiens_hsa03430	0.87506081
57	Fanconi anemia pathway_Homo sapiens_hsa03460	0.84420544
58	Renin-angiotensin system_Homo sapiens_hsa04614	0.83793589
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.83659196
60	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.82078202
61	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.79947006
62	Cardiac muscle contraction_Homo sapiens_hsa04260	0.79833679
63	Olfactory transduction_Homo sapiens_hsa04740	0.79626021
64	Tyrosine metabolism_Homo sapiens_hsa00350	0.77429954
65	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.75572897
66	Retinol metabolism_Homo sapiens_hsa00830	0.74367820
67	Purine metabolism_Homo sapiens_hsa00230	0.74349757
68	Phototransduction_Homo sapiens_hsa04744	0.73778661
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72614199
70	Metabolic pathways_Homo sapiens_hsa01100	0.72042581
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71797357
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70092977
73	Propanoate metabolism_Homo sapiens_hsa00640	0.69784104
74	Serotonergic synapse_Homo sapiens_hsa04726	0.68453254
75	RNA transport_Homo sapiens_hsa03013	0.66763171
76	Sphingolipid metabolism_Homo sapiens_hsa00600	0.65902865
77	Pyrimidine metabolism_Homo sapiens_hsa00240	0.63165814
78	Spliceosome_Homo sapiens_hsa03040	0.63053267
79	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.62657709
80	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.60503068
81	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.59909384
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.59690520
83	Taste transduction_Homo sapiens_hsa04742	0.58788350
84	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.58270791
85	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.57250158
86	Vibrio cholerae infection_Homo sapiens_hsa05110	0.56366708
87	Phenylalanine metabolism_Homo sapiens_hsa00360	0.55612217
88	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.53202329
89	Non-homologous end-joining_Homo sapiens_hsa03450	0.48741982
90	Carbon metabolism_Homo sapiens_hsa01200	0.48042954
91	Pyruvate metabolism_Homo sapiens_hsa00620	0.45938800
92	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.45305798
93	Histidine metabolism_Homo sapiens_hsa00340	0.44554094
94	DNA replication_Homo sapiens_hsa03030	0.44299858
95	Lysosome_Homo sapiens_hsa04142	0.43315657
96	Nicotine addiction_Homo sapiens_hsa05033	0.43273531
97	RNA degradation_Homo sapiens_hsa03018	0.42757112
98	PPAR signaling pathway_Homo sapiens_hsa03320	0.41963738
99	ABC transporters_Homo sapiens_hsa02010	0.41448430
100	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.39768425

MTRNR2L7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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