ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore complex assembly (GO:0051292)	4.13473970
2	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.05230630
3	establishment of protein localization to Golgi (GO:0072600)	3.83118140
4	nuclear pore organization (GO:0006999)	3.62998906
5	cytoplasmic mRNA processing body assembly (GO:0033962)	3.58009688
6	negative regulation of vascular permeability (GO:0043116)	3.56471125
7	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	3.43865847
8	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.42282834
9	protein targeting to Golgi (GO:0000042)	3.28370919
10	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.26541222
11	negative regulation of neurotransmitter secretion (GO:0046929)	3.24709048
12	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.15827806
13	pore complex assembly (GO:0046931)	3.10314039
14	keratinization (GO:0031424)	3.05761538
15	regulation of cAMP-dependent protein kinase activity (GO:2000479)	3.00481109
16	regulation of clathrin-mediated endocytosis (GO:2000369)	2.99437114
17	microtubule anchoring (GO:0034453)	2.99422769
18	interkinetic nuclear migration (GO:0022027)	2.98343841
19	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.98020144
20	regulation of sarcomere organization (GO:0060297)	2.94872970
21	negative regulation of neurotransmitter transport (GO:0051589)	2.93728792
22	fibroblast migration (GO:0010761)	2.83594655
23	glucocorticoid biosynthetic process (GO:0006704)	2.82220448
24	biotin metabolic process (GO:0006768)	2.78874646
25	long-chain fatty acid biosynthetic process (GO:0042759)	2.76389042
26	establishment of skin barrier (GO:0061436)	2.72415536
27	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.70068430
28	positive regulation of muscle hypertrophy (GO:0014742)	2.67446501
29	positive regulation of cardiac muscle hypertrophy (GO:0010613)	2.67446501
30	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.65895174
31	linoleic acid metabolic process (GO:0043651)	2.64304944
32	thrombin receptor signaling pathway (GO:0070493)	2.62339733
33	protein K48-linked deubiquitination (GO:0071108)	2.56344927
34	intra-Golgi vesicle-mediated transport (GO:0006891)	2.56319800
35	Golgi to plasma membrane protein transport (GO:0043001)	2.56162446
36	atrial cardiac muscle cell action potential (GO:0086014)	2.53875141
37	regulation of transforming growth factor beta2 production (GO:0032909)	2.53830924
38	ventricular cardiac muscle cell action potential (GO:0086005)	2.53330650
39	regulation of synaptic vesicle exocytosis (GO:2000300)	2.53250374
40	Golgi to plasma membrane transport (GO:0006893)	2.51830638
41	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	2.51778603
42	cerebellar Purkinje cell differentiation (GO:0021702)	2.49837437
43	microtubule nucleation (GO:0007020)	2.47857769
44	regulation of pigment cell differentiation (GO:0050932)	2.46444165
45	negative regulation of protein localization to cell surface (GO:2000009)	2.45314444
46	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.45105164
47	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.45105164
48	regulation of translation, ncRNA-mediated (GO:0045974)	2.45105164
49	cell communication involved in cardiac conduction (GO:0086065)	2.44187796
50	protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)	2.44049524
51	pre-miRNA processing (GO:0031054)	2.42534245
52	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.41103509
53	microtubule depolymerization (GO:0007019)	2.40590822
54	genitalia morphogenesis (GO:0035112)	2.40420644
55	vesicle transport along microtubule (GO:0047496)	2.39729002
56	androgen biosynthetic process (GO:0006702)	2.38573476
57	regulation of female receptivity (GO:0045924)	2.38367944
58	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.38195381
59	organelle transport along microtubule (GO:0072384)	2.37297603
60	regulation of cofactor metabolic process (GO:0051193)	2.36630429
61	regulation of coenzyme metabolic process (GO:0051196)	2.36630429
62	positive regulation of glycolytic process (GO:0045821)	2.35844353
63	gastrulation with mouth forming second (GO:0001702)	2.35333476
64	desmosome organization (GO:0002934)	2.34726263
65	early endosome to late endosome transport (GO:0045022)	2.34396829
66	Golgi to endosome transport (GO:0006895)	2.34318969
67	protein localization to Golgi apparatus (GO:0034067)	2.33826504
68	regulation of cell communication by electrical coupling (GO:0010649)	2.33242211
69	positive regulation of endothelial cell differentiation (GO:0045603)	2.32689010
70	positive regulation of mitochondrial fission (GO:0090141)	2.32428361
71	clathrin coat assembly (GO:0048268)	2.31357004
72	C4-dicarboxylate transport (GO:0015740)	2.30591649
73	artery development (GO:0060840)	2.30569591
74	regulation of cardioblast differentiation (GO:0051890)	2.30046352
75	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.29816956
76	nucleus localization (GO:0051647)	2.29627732
77	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	2.27388617
78	gamma-aminobutyric acid transport (GO:0015812)	2.26840650
79	peroxisome fission (GO:0016559)	2.26817116
80	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.25700165
81	glutamate secretion (GO:0014047)	2.25584708
82	cardiac muscle cell action potential (GO:0086001)	2.22910078
83	regulation of synaptic vesicle transport (GO:1902803)	2.20154359
84	regulation of lipoprotein metabolic process (GO:0050746)	2.19865503
85	vascular smooth muscle contraction (GO:0014829)	2.19173035
86	COPII vesicle coating (GO:0048208)	2.17888900
87	inositol metabolic process (GO:0006020)	2.17856857
88	cyclic nucleotide catabolic process (GO:0009214)	2.17467461
89	carnitine shuttle (GO:0006853)	2.16075118
90	protein K11-linked deubiquitination (GO:0035871)	2.15081112
91	pyrimidine dimer repair (GO:0006290)	2.14845213
92	coenzyme A biosynthetic process (GO:0015937)	2.14225164
93	morphogenesis of an epithelial sheet (GO:0002011)	2.10785272
94	microtubule polymerization or depolymerization (GO:0031109)	2.10268937
95	negative regulation of blood circulation (GO:1903523)	2.09019601
96	regulation of bile acid biosynthetic process (GO:0070857)	2.08517021
97	nucleobase catabolic process (GO:0046113)	2.07487383
98	cardiac muscle cell action potential involved in contraction (GO:0086002)	2.07337461
99	regulation of sulfur metabolic process (GO:0042762)	2.06722345
100	vesicle docking (GO:0048278)	2.06612871

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.47406337
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.22384638
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.10165868
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.03012855
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.99206726
6	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.91360476
7	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.65026568
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.55929998
9	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.55236707
10	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.51760049
11	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.37412859
12	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.35395189
13	SMAD4_21799915_ChIP-Seq_A2780_Human	2.26759564
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.26357589
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.19217990
16	P300_19829295_ChIP-Seq_ESCs_Human	1.94818641
17	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.94484131
18	STAT3_23295773_ChIP-Seq_U87_Human	1.93727905
19	FUS_26573619_Chip-Seq_HEK293_Human	1.93127667
20	AR_21572438_ChIP-Seq_LNCaP_Human	1.91340354
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.87720697
22	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.86570806
23	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.84559031
24	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.82732655
25	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.72925829
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.68622999
27	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.65240782
28	TCF4_23295773_ChIP-Seq_U87_Human	1.59996218
29	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.56605848
30	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.51660448
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49960855
32	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.49562885
33	EWS_26573619_Chip-Seq_HEK293_Human	1.47977099
34	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.47892799
35	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.45872155
36	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.41848540
37	AHR_22903824_ChIP-Seq_MCF-7_Human	1.40162485
38	AR_25329375_ChIP-Seq_VCAP_Human	1.39943884
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.39916882
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39916882
41	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.39899200
42	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.38608165
43	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.36340598
44	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.35353122
45	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.33835836
46	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.33093654
47	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.31764390
48	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.31764390
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.28289766
50	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.27500147
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26976733
52	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.26391554
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26343063
54	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.24979061
55	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.24312795
56	IRF1_19129219_ChIP-ChIP_H3396_Human	1.24305123
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.24008008
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19322823
59	TP53_16413492_ChIP-PET_HCT116_Human	1.18779564
60	ZNF274_21170338_ChIP-Seq_K562_Hela	1.18566127
61	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17156656
62	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.16719021
63	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.16071730
64	CDX2_22108803_ChIP-Seq_LS180_Human	1.15594119
65	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.15574734
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.15233421
67	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.13754843
68	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.13215494
69	ER_23166858_ChIP-Seq_MCF-7_Human	1.13172910
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.13136659
71	SOX9_26525672_Chip-Seq_HEART_Mouse	1.12720522
72	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.12585093
73	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.11896347
74	P53_22387025_ChIP-Seq_ESCs_Mouse	1.11703000
75	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11421730
76	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.10646526
77	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.10636577
78	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.10552972
79	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08669272
80	GATA1_22025678_ChIP-Seq_K562_Human	1.07345631
81	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.06057471
82	VDR_22108803_ChIP-Seq_LS180_Human	1.05541217
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05489100
84	TP53_18474530_ChIP-ChIP_U2OS_Human	1.04531575
85	AR_19668381_ChIP-Seq_PC3_Human	1.03491518
86	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.01788267
87	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01270667
88	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.00520892
89	TBL1_22424771_ChIP-Seq_293T_Human	1.00179855
90	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00122509
91	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.00038703
92	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00038703
93	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97419903
94	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.95879971
95	JUN_21703547_ChIP-Seq_K562_Human	0.95205373
96	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.95045135
97	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.94496229
98	BCAT_22108803_ChIP-Seq_LS180_Human	0.94023638
99	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93651456
100	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.93552400

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010352_gastrointestinal_tract_polyps	3.24273147
2	MP0002009_preneoplasia	3.23310801
3	MP0008057_abnormal_DNA_replication	2.65545940
4	MP0003941_abnormal_skin_development	2.62311655
5	MP0000569_abnormal_digit_pigmentation	2.46177930
6	MP0009697_abnormal_copulation	2.33638164
7	MP0009780_abnormal_chondrocyte_physiolo	2.32702959
8	MP0004270_analgesia	2.23645143
9	MP0008004_abnormal_stomach_pH	2.08454162
10	MP0009046_muscle_twitch	2.03778863
11	MP0004859_abnormal_synaptic_plasticity	1.89602924
12	MP0001984_abnormal_olfaction	1.80348687
13	MP0004084_abnormal_cardiac_muscle	1.77859465
14	MP0005670_abnormal_white_adipose	1.73765781
15	MP0005187_abnormal_penis_morphology	1.69692914
16	MP0004036_abnormal_muscle_relaxation	1.69200298
17	MP0006276_abnormal_autonomic_nervous	1.67451862
18	MP0003890_abnormal_embryonic-extraembry	1.62382981
19	MP0000383_abnormal_hair_follicle	1.56586432
20	MP0005646_abnormal_pituitary_gland	1.53768769
21	MP0001188_hyperpigmentation	1.46524094
22	MP0001486_abnormal_startle_reflex	1.46290821
23	MP0004130_abnormal_muscle_cell	1.44567354
24	MP0000465_gastrointestinal_hemorrhage	1.43592250
25	MP0004233_abnormal_muscle_weight	1.43180682
26	MP0003880_abnormal_central_pattern	1.41740579
27	MP0004134_abnormal_chest_morphology	1.40452157
28	MP0000013_abnormal_adipose_tissue	1.39763086
29	MP0000647_abnormal_sebaceous_gland	1.36092205
30	MP0001661_extended_life_span	1.32347465
31	MP0005409_darkened_coat_color	1.32063924
32	MP0004215_abnormal_myocardial_fiber	1.30989424
33	MP0004484_altered_response_of	1.28585281
34	MP0001299_abnormal_eye_distance/	1.28026599
35	MP0001879_abnormal_lymphatic_vessel	1.25822442
36	MP0005275_abnormal_skin_tensile	1.25733199
37	MP0004924_abnormal_behavior	1.25151905
38	MP0005386_behavior/neurological_phenoty	1.25151905
39	MP0010678_abnormal_skin_adnexa	1.24604906
40	MP0004147_increased_porphyrin_level	1.23960152
41	MP0004085_abnormal_heartbeat	1.22688143
42	MP0003635_abnormal_synaptic_transmissio	1.21676307
43	MP0003646_muscle_fatigue	1.21542917
44	MP0001666_abnormal_nutrient_absorption	1.15313648
45	MP0002876_abnormal_thyroid_physiology	1.14483477
46	MP0002063_abnormal_learning/memory/cond	1.12450057
47	MP0003868_abnormal_feces_composition	1.09605046
48	MP0000427_abnormal_hair_cycle	1.09375770
49	MP0004264_abnormal_extraembryonic_tissu	1.07947778
50	MP0005083_abnormal_biliary_tract	1.07586883
51	MP0002272_abnormal_nervous_system	1.06668463
52	MP0010329_abnormal_lipoprotein_level	1.04495197
53	MP0002064_seizures	1.03016834
54	MP0002796_impaired_skin_barrier	1.02996126
55	MP0002557_abnormal_social/conspecific_i	1.02937696
56	MP0005167_abnormal_blood-brain_barrier	1.01876449
57	MP0008877_abnormal_DNA_methylation	1.00648418
58	MP0001501_abnormal_sleep_pattern	0.97346816
59	MP0005253_abnormal_eye_physiology	0.96123060
60	MP0002572_abnormal_emotion/affect_behav	0.95982229
61	MP0002234_abnormal_pharynx_morphology	0.95327791
62	MP0001529_abnormal_vocalization	0.93925471
63	MP0000631_abnormal_neuroendocrine_gland	0.93368563
64	MP0003879_abnormal_hair_cell	0.92851883
65	MP0008995_early_reproductive_senescence	0.92146637
66	MP0005501_abnormal_skin_physiology	0.91688612
67	MP0003137_abnormal_impulse_conducting	0.90739060
68	MP0005645_abnormal_hypothalamus_physiol	0.89700576
69	MP0003718_maternal_effect	0.88661282
70	MP0003183_abnormal_peptide_metabolism	0.88269837
71	MP0008961_abnormal_basal_metabolism	0.87735437
72	MP0006138_congestive_heart_failure	0.87415116
73	MP0002102_abnormal_ear_morphology	0.86122532
74	MP0005085_abnormal_gallbladder_physiolo	0.85735587
75	MP0002822_catalepsy	0.85656354
76	MP0000003_abnormal_adipose_tissue	0.85540664
77	MP0004272_abnormal_basement_membrane	0.84434799
78	MP0001502_abnormal_circadian_rhythm	0.83904220
79	MP0008775_abnormal_heart_ventricle	0.83578243
80	MP0003937_abnormal_limbs/digits/tail_de	0.83138180
81	MP0005365_abnormal_bile_salt	0.82672985
82	MP0002638_abnormal_pupillary_reflex	0.82090261
83	MP0000230_abnormal_systemic_arterial	0.81775604
84	MP0000778_abnormal_nervous_system	0.81179152
85	MP0009115_abnormal_fat_cell	0.80868661
86	MP0001177_atelectasis	0.78959722
87	MP0009745_abnormal_behavioral_response	0.77702433
88	MP0003633_abnormal_nervous_system	0.77116191
89	MP0003787_abnormal_imprinting	0.76823855
90	MP0001293_anophthalmia	0.76291746
91	MP0004811_abnormal_neuron_physiology	0.76006782
92	MP0005551_abnormal_eye_electrophysiolog	0.75658677
93	MP0005666_abnormal_adipose_tissue	0.75056031
94	MP0000639_abnormal_adrenal_gland	0.74033657
95	MP0009703_decreased_birth_body	0.69960142
96	MP0010368_abnormal_lymphatic_system	0.69386107
97	MP0005620_abnormal_muscle_contractility	0.69048926
98	MP0001191_abnormal_skin_condition	0.68827374
99	MP0002067_abnormal_sensory_capabilities	0.68810758
100	MP0001286_abnormal_eye_development	0.66290372

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Papillary thyroid carcinoma (HP:0002895)	4.49962674
2	Right ventricular cardiomyopathy (HP:0011663)	3.14005849
3	Hepatoblastoma (HP:0002884)	2.92678781
4	Drooling (HP:0002307)	2.86831976
5	Genetic anticipation (HP:0003743)	2.83578809
6	Tubulointerstitial nephritis (HP:0001970)	2.82544468
7	Hyperventilation (HP:0002883)	2.75256550
8	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.75070231
9	Urinary urgency (HP:0000012)	2.61910710
10	Abnormality of the astrocytes (HP:0100707)	2.61442547
11	Astrocytoma (HP:0009592)	2.61442547
12	Thyroid carcinoma (HP:0002890)	2.57135537
13	Insidious onset (HP:0003587)	2.55358690
14	Termporal pattern (HP:0011008)	2.55358690
15	Febrile seizures (HP:0002373)	2.54596939
16	Cortical dysplasia (HP:0002539)	2.53889001
17	Excessive salivation (HP:0003781)	2.49401413
18	Acanthocytosis (HP:0001927)	2.49312739
19	Progressive cerebellar ataxia (HP:0002073)	2.49118292
20	Atonic seizures (HP:0010819)	2.38623544
21	Gaze-evoked nystagmus (HP:0000640)	2.38137089
22	Medulloblastoma (HP:0002885)	2.37045330
23	Short tibia (HP:0005736)	2.36675047
24	Urinary bladder sphincter dysfunction (HP:0002839)	2.36578906
25	Abnormality of the axillary hair (HP:0100134)	2.34896008
26	Abnormality of secondary sexual hair (HP:0009888)	2.34896008
27	Hypoplastic labia majora (HP:0000059)	2.33333916
28	Truncal obesity (HP:0001956)	2.28967304
29	Epileptiform EEG discharges (HP:0011182)	2.28158188
30	EEG with generalized epileptiform discharges (HP:0011198)	2.24504026
31	Hypsarrhythmia (HP:0002521)	2.23705107
32	Absent eyelashes (HP:0000561)	2.22613080
33	Autoamputation (HP:0001218)	2.21555594
34	Absent eyebrow (HP:0002223)	2.18006314
35	Broad-based gait (HP:0002136)	2.17561273
36	Impaired vibration sensation in the lower limbs (HP:0002166)	2.17105168
37	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.16609175
38	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.16609175
39	Abnormality of the labia majora (HP:0012881)	2.16337450
40	Decreased lacrimation (HP:0000633)	2.15109974
41	Poor coordination (HP:0002370)	2.14176992
42	Chronic hepatic failure (HP:0100626)	2.13640278
43	Curly hair (HP:0002212)	2.12174040
44	Abnormal auditory evoked potentials (HP:0006958)	2.05458725
45	Genital tract atresia (HP:0001827)	2.04249395
46	Thyroid-stimulating hormone excess (HP:0002925)	2.02752725
47	Fair hair (HP:0002286)	2.02005197
48	Gait imbalance (HP:0002141)	2.01046970
49	Abnormality of the left ventricular outflow tract (HP:0011103)	1.99917094
50	Subaortic stenosis (HP:0001682)	1.99917094
51	Vaginal atresia (HP:0000148)	1.97533133
52	Glioma (HP:0009733)	1.97206100
53	Increased mean platelet volume (HP:0011877)	1.97079065
54	Congenital primary aphakia (HP:0007707)	1.96647589
55	Labial hypoplasia (HP:0000066)	1.96289260
56	Renal cortical cysts (HP:0000803)	1.94242901
57	Rhabdomyosarcoma (HP:0002859)	1.93583414
58	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.89556750
59	Abnormality of the corticospinal tract (HP:0002492)	1.88234748
60	Colon cancer (HP:0003003)	1.88177473
61	Absent hair (HP:0002298)	1.88016243
62	Spastic gait (HP:0002064)	1.87582947
63	Ectropion (HP:0000656)	1.84908571
64	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.83197450
65	Hyperkalemia (HP:0002153)	1.80797414
66	Medial flaring of the eyebrow (HP:0010747)	1.79580307
67	Volvulus (HP:0002580)	1.79541409
68	Acute myeloid leukemia (HP:0004808)	1.77049481
69	Overgrowth (HP:0001548)	1.76902657
70	Decreased circulating renin level (HP:0003351)	1.75892114
71	Deep philtrum (HP:0002002)	1.75601431
72	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.74419300
73	Partial agenesis of the corpus callosum (HP:0001338)	1.73603680
74	Cystic hygroma (HP:0000476)	1.72709068
75	Biliary tract neoplasm (HP:0100574)	1.72646630
76	Nephrogenic diabetes insipidus (HP:0009806)	1.72283485
77	Neoplasm of striated muscle (HP:0009728)	1.71605910
78	Menorrhagia (HP:0000132)	1.71327605
79	Cutaneous finger syndactyly (HP:0010554)	1.70561278
80	Papilledema (HP:0001085)	1.70430716
81	Lower limb muscle weakness (HP:0007340)	1.70037682
82	Dysmetric saccades (HP:0000641)	1.69905489
83	Double outlet right ventricle (HP:0001719)	1.68690039
84	Congenital malformation of the right heart (HP:0011723)	1.68690039
85	Insulin-resistant diabetes mellitus (HP:0000831)	1.68116959
86	Absent speech (HP:0001344)	1.65757994
87	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.65307899
88	Abnormality of nail color (HP:0100643)	1.64922980
89	Impaired social interactions (HP:0000735)	1.64856588
90	Abnormal social behavior (HP:0012433)	1.64856588
91	Abnormality of the fingertips (HP:0001211)	1.64711739
92	Submucous cleft hard palate (HP:0000176)	1.64087951
93	Hypoplastic female external genitalia (HP:0012815)	1.63392432
94	Blue irides (HP:0000635)	1.62831019
95	Bifid tongue (HP:0010297)	1.60993321
96	Impaired vibratory sensation (HP:0002495)	1.60814092
97	Failure to thrive in infancy (HP:0001531)	1.59287506
98	Syncope (HP:0001279)	1.58928165
99	Short chin (HP:0000331)	1.58534794
100	Alacrima (HP:0000522)	1.56885689

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	AKT3	4.09078091
2	MAP3K4	3.27204814
3	CAMK1G	2.56072396
4	MAP2K7	2.46782245
5	CAMK1D	2.39948547
6	EPHA3	2.36527921
7	CASK	2.25962348
8	FRK	2.21320012
9	CSNK1A1L	2.16302544
10	CDK12	1.93445575
11	SGK2	1.89583968
12	BCR	1.88591013
13	STK39	1.85165758
14	MAP4K2	1.84233023
15	FER	1.78094126
16	CSNK1G1	1.75207755
17	ZAK	1.63236608
18	CSNK1G3	1.56784285
19	NLK	1.52101932
20	SGK223	1.51942186
21	SGK494	1.51942186
22	BRD4	1.44699850
23	EPHA4	1.40419648
24	CSNK1G2	1.38991235
25	ERBB3	1.33071570
26	CAMKK2	1.24977035
27	SGK3	1.24505670
28	MARK1	1.24019134
29	MST4	1.20728089
30	MET	1.17881008
31	WNK3	1.16588790
32	ACVR1B	1.15794212
33	PIK3CA	1.15403765
34	TAOK3	1.10885429
35	LATS1	1.10589097
36	MAPK13	1.07039821
37	PIK3CG	1.05571065
38	BRSK2	1.03558500
39	PRKAA1	1.03230337
40	CAMK4	1.03030775
41	SCYL2	1.00835930
42	BMPR1B	0.98994622
43	PRKAA2	0.97460154
44	MAP3K6	0.96288519
45	OBSCN	0.94030120
46	PINK1	0.90105215
47	STK38	0.89988386
48	PAK3	0.88818622
49	MAP2K4	0.87087396
50	WNK1	0.86782288
51	CAMK1	0.86156565
52	TLK1	0.83228018
53	PAK6	0.83154018
54	PLK2	0.82298160
55	NTRK3	0.81037576
56	STK38L	0.79215714
57	MYLK	0.78785643
58	MARK2	0.78405582
59	SRPK1	0.77632060
60	RPS6KA5	0.76407715
61	PRKCE	0.74817475
62	OXSR1	0.69396427
63	TRIM28	0.69379909
64	MST1R	0.67877786
65	TNIK	0.67711750
66	FLT3	0.64582150
67	INSRR	0.64006139
68	TEC	0.63269248
69	MAP3K5	0.61858274
70	CDK6	0.60315945
71	NUAK1	0.60126979
72	SGK1	0.58524363
73	CDK5	0.57554920
74	MELK	0.57320591
75	PBK	0.54468788
76	PKN1	0.51985987
77	CSNK1D	0.48050676
78	ATM	0.46571177
79	MAPK10	0.45360463
80	RPS6KA3	0.45321176
81	WNK4	0.44874617
82	CDK19	0.44310313
83	MAP3K2	0.42694864
84	FGFR1	0.42588484
85	CAMK2A	0.42386415
86	LMTK2	0.41696257
87	PRKD3	0.41646369
88	DYRK1B	0.41636952
89	NTRK2	0.41522787
90	NEK1	0.41087931
91	JAK1	0.40168211
92	PLK4	0.39887965
93	DAPK2	0.39138540
94	STK3	0.38967039
95	PHKG2	0.38844106
96	PHKG1	0.38844106
97	TIE1	0.38834169
98	NEK6	0.37013509
99	GSK3B	0.36461747
100	BMPR2	0.36177856

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Alcoholism_Homo sapiens_hsa05034	2.83261689
2	Circadian rhythm_Homo sapiens_hsa04710	2.51168446
3	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.33601514
4	Nicotine addiction_Homo sapiens_hsa05033	2.17039727
5	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.95170868
6	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.83777752
7	GABAergic synapse_Homo sapiens_hsa04727	1.58228565
8	Fat digestion and absorption_Homo sapiens_hsa04975	1.56365936
9	Adherens junction_Homo sapiens_hsa04520	1.54264680
10	Renin-angiotensin system_Homo sapiens_hsa04614	1.44387951
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.42012459
12	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.41905892
13	Steroid biosynthesis_Homo sapiens_hsa00100	1.33960107
14	Morphine addiction_Homo sapiens_hsa05032	1.27167815
15	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.26498208
16	Propanoate metabolism_Homo sapiens_hsa00640	1.25887755
17	Pancreatic secretion_Homo sapiens_hsa04972	1.24398685
18	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.18558901
19	Circadian entrainment_Homo sapiens_hsa04713	1.18358500
20	Dopaminergic synapse_Homo sapiens_hsa04728	1.18005541
21	Arginine biosynthesis_Homo sapiens_hsa00220	1.17999829
22	Serotonergic synapse_Homo sapiens_hsa04726	1.16300436
23	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.14909456
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.14713747
25	Fatty acid elongation_Homo sapiens_hsa00062	1.13323977
26	Taste transduction_Homo sapiens_hsa04742	1.12551469
27	Lysine degradation_Homo sapiens_hsa00310	1.12483243
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.12465612
29	Amphetamine addiction_Homo sapiens_hsa05031	1.07203809
30	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.04437349
31	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.04101337
32	Fatty acid metabolism_Homo sapiens_hsa01212	1.03521465
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.03207580
34	Sulfur metabolism_Homo sapiens_hsa00920	1.02019202
35	Long-term depression_Homo sapiens_hsa04730	1.00905599
36	Insulin secretion_Homo sapiens_hsa04911	1.00801945
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.99286656
38	Gap junction_Homo sapiens_hsa04540	0.98683719
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.97718930
40	Salivary secretion_Homo sapiens_hsa04970	0.94897351
41	Butanoate metabolism_Homo sapiens_hsa00650	0.94817841
42	Linoleic acid metabolism_Homo sapiens_hsa00591	0.92400196
43	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.91265295
44	Renin secretion_Homo sapiens_hsa04924	0.91079785
45	beta-Alanine metabolism_Homo sapiens_hsa00410	0.90343825
46	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.89529760
47	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.89394763
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.87944548
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.86427574
50	Olfactory transduction_Homo sapiens_hsa04740	0.86162583
51	Long-term potentiation_Homo sapiens_hsa04720	0.84399266
52	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.82044137
53	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.81806565
54	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.79539642
55	Thyroid cancer_Homo sapiens_hsa05216	0.78295778
56	Cocaine addiction_Homo sapiens_hsa05030	0.77621886
57	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.76597972
58	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.76217576
59	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.76150943
60	Sphingolipid metabolism_Homo sapiens_hsa00600	0.75968871
61	cAMP signaling pathway_Homo sapiens_hsa04024	0.73783646
62	Oocyte meiosis_Homo sapiens_hsa04114	0.72656758
63	Tight junction_Homo sapiens_hsa04530	0.72084031
64	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.71767066
65	Arginine and proline metabolism_Homo sapiens_hsa00330	0.71330366
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70500516
67	Glucagon signaling pathway_Homo sapiens_hsa04922	0.69765059
68	Platelet activation_Homo sapiens_hsa04611	0.69242068
69	PPAR signaling pathway_Homo sapiens_hsa03320	0.68168879
70	Nitrogen metabolism_Homo sapiens_hsa00910	0.68127153
71	Type II diabetes mellitus_Homo sapiens_hsa04930	0.67004836
72	Non-homologous end-joining_Homo sapiens_hsa03450	0.66866247
73	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.66656705
74	Hippo signaling pathway_Homo sapiens_hsa04390	0.66578437
75	AMPK signaling pathway_Homo sapiens_hsa04152	0.66187856
76	Ether lipid metabolism_Homo sapiens_hsa00565	0.64944159
77	Calcium signaling pathway_Homo sapiens_hsa04020	0.64716098
78	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.64575923
79	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.63591009
80	ABC transporters_Homo sapiens_hsa02010	0.63490839
81	Viral carcinogenesis_Homo sapiens_hsa05203	0.62254526
82	Protein digestion and absorption_Homo sapiens_hsa04974	0.60741547
83	Choline metabolism in cancer_Homo sapiens_hsa05231	0.59884682
84	Glioma_Homo sapiens_hsa05214	0.59273807
85	Cholinergic synapse_Homo sapiens_hsa04725	0.59223496
86	Peroxisome_Homo sapiens_hsa04146	0.59099105
87	ECM-receptor interaction_Homo sapiens_hsa04512	0.57542703
88	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.57119089
89	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.57006378
90	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.56074792
91	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.54754515
92	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.52652304
93	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.52471636
94	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.51553220
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51432113
96	ErbB signaling pathway_Homo sapiens_hsa04012	0.50424977
97	Wnt signaling pathway_Homo sapiens_hsa04310	0.49246525
98	Vibrio cholerae infection_Homo sapiens_hsa05110	0.48376790
99	Gastric acid secretion_Homo sapiens_hsa04971	0.47687045
100	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.47594963

MTRNR2L8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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