MTSS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.95211966
2L-phenylalanine catabolic process (GO:0006559)6.95211966
3L-phenylalanine metabolic process (GO:0006558)6.47664528
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.47664528
5aromatic amino acid family catabolic process (GO:0009074)6.12924611
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.67563536
7tryptophan catabolic process (GO:0006569)5.41767013
8indole-containing compound catabolic process (GO:0042436)5.41767013
9indolalkylamine catabolic process (GO:0046218)5.41767013
10kynurenine metabolic process (GO:0070189)5.38661109
11alpha-linolenic acid metabolic process (GO:0036109)5.36184746
12glyoxylate metabolic process (GO:0046487)5.17706231
13urea metabolic process (GO:0019627)5.17091248
14urea cycle (GO:0000050)5.17091248
15bile acid biosynthetic process (GO:0006699)5.09901260
16tryptophan metabolic process (GO:0006568)5.07905829
17complement activation, alternative pathway (GO:0006957)4.94252434
18negative regulation of fibrinolysis (GO:0051918)4.92027788
19protein carboxylation (GO:0018214)4.91905047
20peptidyl-glutamic acid carboxylation (GO:0017187)4.91905047
21pyrimidine nucleobase catabolic process (GO:0006208)4.91698947
22regulation of protein activation cascade (GO:2000257)4.88901396
23high-density lipoprotein particle remodeling (GO:0034375)4.77936473
24nitrogen cycle metabolic process (GO:0071941)4.68809581
25regulation of fibrinolysis (GO:0051917)4.62846578
26regulation of complement activation (GO:0030449)4.57310108
27bile acid metabolic process (GO:0008206)4.49675300
28cysteine metabolic process (GO:0006534)4.40174459
29serine family amino acid catabolic process (GO:0009071)4.32048347
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.30687646
31phospholipid efflux (GO:0033700)4.29557619
32aromatic amino acid family metabolic process (GO:0009072)4.29319554
33lysine metabolic process (GO:0006553)4.28491244
34lysine catabolic process (GO:0006554)4.28491244
35cellular ketone body metabolic process (GO:0046950)4.28324940
36tyrosine metabolic process (GO:0006570)4.27965276
37reverse cholesterol transport (GO:0043691)4.27598505
38sulfur amino acid catabolic process (GO:0000098)4.26986167
39acylglycerol homeostasis (GO:0055090)4.20048753
40triglyceride homeostasis (GO:0070328)4.20048753
41nucleobase catabolic process (GO:0046113)4.18998550
42ionotropic glutamate receptor signaling pathway (GO:0035235)4.17091379
43negative regulation of cholesterol transport (GO:0032375)4.16940196
44negative regulation of sterol transport (GO:0032372)4.16940196
45regulation of triglyceride catabolic process (GO:0010896)4.09221583
46regulation of cholesterol esterification (GO:0010872)4.08181826
47alpha-amino acid catabolic process (GO:1901606)4.06534666
48plasma lipoprotein particle remodeling (GO:0034369)4.00843324
49protein-lipid complex remodeling (GO:0034368)4.00843324
50macromolecular complex remodeling (GO:0034367)4.00843324
51coenzyme catabolic process (GO:0009109)3.98669486
52plasma lipoprotein particle clearance (GO:0034381)3.97025211
53glutamate metabolic process (GO:0006536)3.96813850
54regulation of cholesterol homeostasis (GO:2000188)3.95984097
55dicarboxylic acid biosynthetic process (GO:0043650)3.95228111
56cholesterol efflux (GO:0033344)3.94353137
57homocysteine metabolic process (GO:0050667)3.91444309
58indolalkylamine metabolic process (GO:0006586)3.90304463
59drug catabolic process (GO:0042737)3.90053768
60arginine metabolic process (GO:0006525)3.84350450
61phospholipid homeostasis (GO:0055091)3.82141001
62amino-acid betaine metabolic process (GO:0006577)3.78919305
63neuron cell-cell adhesion (GO:0007158)3.74696506
64acetyl-CoA metabolic process (GO:0006084)3.69460589
65cellular amino acid catabolic process (GO:0009063)3.68398639
66bile acid and bile salt transport (GO:0015721)3.65191076
67ketone body metabolic process (GO:1902224)3.64158081
68regulation of bile acid biosynthetic process (GO:0070857)3.63427745
69positive regulation of fatty acid beta-oxidation (GO:0032000)3.61670572
70cellular modified amino acid catabolic process (GO:0042219)3.57340537
71benzene-containing compound metabolic process (GO:0042537)3.56755928
72cellular glucuronidation (GO:0052695)3.56566068
73complement activation, classical pathway (GO:0006958)3.55468506
74positive regulation of lipid catabolic process (GO:0050996)3.55064336
75plasma lipoprotein particle assembly (GO:0034377)3.53236443
76gamma-aminobutyric acid transport (GO:0015812)3.52636189
77complement activation (GO:0006956)3.50572851
78postsynaptic membrane organization (GO:0001941)3.50296210
79neurotransmitter-gated ion channel clustering (GO:0072578)3.49378255
80cellular biogenic amine catabolic process (GO:0042402)3.48812537
81amine catabolic process (GO:0009310)3.48812537
82imidazole-containing compound metabolic process (GO:0052803)3.48308620
83ethanol oxidation (GO:0006069)3.47004494
84exogenous drug catabolic process (GO:0042738)3.46353294
85fibrinolysis (GO:0042730)3.46251874
86negative regulation of protein activation cascade (GO:2000258)3.35435642
87cholesterol homeostasis (GO:0042632)3.34525976
88glutamate receptor signaling pathway (GO:0007215)3.34211643
89protein activation cascade (GO:0072376)3.32839189
90sterol homeostasis (GO:0055092)3.30793874
91protein-lipid complex assembly (GO:0065005)3.28423699
92synaptic transmission, glutamatergic (GO:0035249)3.28149379
93presynaptic membrane assembly (GO:0097105)3.27921828
94regulation of fatty acid beta-oxidation (GO:0031998)3.27128126
95cofactor catabolic process (GO:0051187)3.25664551
96negative regulation of lipase activity (GO:0060192)3.24186673
97membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.21872783
98low-density lipoprotein particle remodeling (GO:0034374)3.21417491
99presynaptic membrane organization (GO:0097090)3.21016865
100short-chain fatty acid metabolic process (GO:0046459)3.20672190
101glycine metabolic process (GO:0006544)3.19238514
102serine family amino acid metabolic process (GO:0009069)3.18775930
103organic acid catabolic process (GO:0016054)3.15830854
104carboxylic acid catabolic process (GO:0046395)3.15830854
105lipoprotein metabolic process (GO:0042157)3.14157070
106epoxygenase P450 pathway (GO:0019373)3.13379025
107vocalization behavior (GO:0071625)3.13140980
108aspartate family amino acid catabolic process (GO:0009068)3.12465640
109glucuronate metabolic process (GO:0019585)3.11974421
110uronic acid metabolic process (GO:0006063)3.11974421
111cerebellar granule cell differentiation (GO:0021707)3.10909324
112plasma lipoprotein particle organization (GO:0071827)3.10781376
113neuronal action potential propagation (GO:0019227)2.99295020
114positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.97211056
115synaptic vesicle maturation (GO:0016188)2.96078988
116regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.90894608
117neuron-neuron synaptic transmission (GO:0007270)2.90144844
118regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.89019448
119nerve growth factor signaling pathway (GO:0038180)2.88523760
120negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.88277858
121positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.82939907
122synaptic vesicle exocytosis (GO:0016079)2.80446826
123regulation of synaptic vesicle exocytosis (GO:2000300)2.80250463
124synapse assembly (GO:0007416)2.79507392
125neuron recognition (GO:0008038)2.78689462
126axonal fasciculation (GO:0007413)2.78403396
127regulation of synapse structural plasticity (GO:0051823)2.75836828
128dendritic spine morphogenesis (GO:0060997)2.75827751
129positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.74585729
130positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.71892211
131regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.70746016
132neurotransmitter secretion (GO:0007269)2.69138213
133regulation of synaptic vesicle transport (GO:1902803)2.68314310
134glycosphingolipid biosynthetic process (GO:0006688)2.67559282
135membrane depolarization during action potential (GO:0086010)2.64604552
136cerebellar Purkinje cell differentiation (GO:0021702)2.61175539
137regulation of synaptic transmission, glutamatergic (GO:0051966)2.58565919
138regulation of glutamate receptor signaling pathway (GO:1900449)2.57076393
139startle response (GO:0001964)2.56671566
140protein localization to synapse (GO:0035418)2.55970425
141positive regulation of amino acid transport (GO:0051957)2.55603241
142neurofilament cytoskeleton organization (GO:0060052)2.55456805
143dendrite morphogenesis (GO:0048813)2.52603797
144exploration behavior (GO:0035640)2.45367002
145C4-dicarboxylate transport (GO:0015740)2.44165032
146locomotory exploration behavior (GO:0035641)2.44124066
147positive regulation of potassium ion transmembrane transport (GO:1901381)2.42919962
148auditory behavior (GO:0031223)2.41376490
149detection of calcium ion (GO:0005513)2.38985950
150negative regulation of synaptic transmission, GABAergic (GO:0032229)2.36907385
151regulation of neuron projection regeneration (GO:0070570)2.36492862
152regulation of axon regeneration (GO:0048679)2.36492862
153cell differentiation in hindbrain (GO:0021533)2.34025327
154G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.28869675
155transmission of nerve impulse (GO:0019226)2.26432930
156negative regulation of neurotransmitter transport (GO:0051589)2.25364855
157regulation of excitatory postsynaptic membrane potential (GO:0060079)2.24809294
158activated T cell proliferation (GO:0050798)2.24128394
159positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.22558785
160negative regulation of synaptic transmission (GO:0050805)2.20551930
161neuronal action potential (GO:0019228)2.20440367
162regulation of postsynaptic membrane potential (GO:0060078)2.20019280
163short-term memory (GO:0007614)2.19489413
164establishment of mitochondrion localization (GO:0051654)2.18169389
165regulation of neurotransmitter levels (GO:0001505)2.18099954
166membrane depolarization (GO:0051899)2.17976520
167cellular sodium ion homeostasis (GO:0006883)2.17540082
168synapse organization (GO:0050808)2.16740623
169behavioral response to nicotine (GO:0035095)2.15582653
170negative regulation of neurotransmitter secretion (GO:0046929)2.14273597
171mechanosensory behavior (GO:0007638)2.14150976
172gamma-aminobutyric acid signaling pathway (GO:0007214)2.13202995
173negative regulation of cytosolic calcium ion concentration (GO:0051481)2.11611589
174regulation of membrane repolarization (GO:0060306)2.10598127
175positive regulation of synapse maturation (GO:0090129)2.08500679
176regulation of dendritic spine morphogenesis (GO:0061001)2.08199888
177long-term synaptic potentiation (GO:0060291)2.08133167
178regulation of dendritic spine development (GO:0060998)2.07968684
179negative regulation of dendrite development (GO:2000171)2.07523682
180adult walking behavior (GO:0007628)2.07191858
181regulation of short-term neuronal synaptic plasticity (GO:0048172)2.06257874
182regulation of neurotransmitter secretion (GO:0046928)2.06254119
183calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.05864766
184glutamate secretion (GO:0014047)2.05248104
185regulation of synapse maturation (GO:0090128)2.04218575
186negative regulation of immunoglobulin mediated immune response (GO:0002890)2.04113233
187negative regulation of B cell mediated immunity (GO:0002713)2.04113233
188cerebral cortex radially oriented cell migration (GO:0021799)2.03759797
189long-chain fatty acid biosynthetic process (GO:0042759)2.03632668
190regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.02818205
191regulation of sarcomere organization (GO:0060297)2.02101381
192central nervous system projection neuron axonogenesis (GO:0021952)2.01683653
193positive regulation of membrane potential (GO:0045838)2.00486552
194neurotransmitter transport (GO:0006836)1.97394223
195neurotransmitter metabolic process (GO:0042133)1.97177249

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.73374866
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.38861337
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.42445561
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.20458235
5EZH2_22144423_ChIP-Seq_EOC_Human4.72098841
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.40634851
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.09845824
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.57579283
9GBX2_23144817_ChIP-Seq_PC3_Human3.43267085
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.30857448
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.88997169
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16526243
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.06313605
14REST_21632747_ChIP-Seq_MESCs_Mouse2.04474107
15TAF15_26573619_Chip-Seq_HEK293_Human2.03438970
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95942850
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.92768788
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87167072
19* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86185519
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.82205520
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81079502
22* CLOCK_20551151_ChIP-Seq_293T_Human1.78564451
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72196315
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71422653
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67788672
26SMAD4_21799915_ChIP-Seq_A2780_Human1.66529565
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.63365518
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62156455
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59842330
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58510535
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.55579351
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53739342
33ZNF274_21170338_ChIP-Seq_K562_Hela1.51835409
34VDR_22108803_ChIP-Seq_LS180_Human1.48664695
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47341992
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45116462
37* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44694036
38IGF1R_20145208_ChIP-Seq_DFB_Human1.42508274
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41405440
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41313785
41P300_19829295_ChIP-Seq_ESCs_Human1.41084880
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40532277
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38300380
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33634352
45STAT3_23295773_ChIP-Seq_U87_Human1.32785718
46* AR_25329375_ChIP-Seq_VCAP_Human1.31317260
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30276320
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30276320
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.30049916
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.28223537
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27317254
52* TCF4_23295773_ChIP-Seq_U87_Human1.27130583
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26260179
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23656286
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.23622231
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23447345
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.23253701
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.22569870
59* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21441951
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.21292460
61* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20392656
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20380585
63* HNF4A_19822575_ChIP-Seq_HepG2_Human1.19609297
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19119720
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19119720
66* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18620039
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.18381467
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.18046053
69* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17128820
70* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16757817
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14686435
72* ER_23166858_ChIP-Seq_MCF-7_Human1.13709654
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12346322
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12341240
75KDM2B_26808549_Chip-Seq_K562_Human1.11282932
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10737243
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.10254620
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08054291
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08042267
80RNF2_27304074_Chip-Seq_NSC_Mouse1.07928815
81* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07552112
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07523758
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06331298
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.05194976
85RARB_27405468_Chip-Seq_BRAIN_Mouse1.03960804
86* RUNX2_22187159_ChIP-Seq_PCA_Human1.03467292
87* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02659218
88* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02633860
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02363583
90* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01319421
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00854674
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00441978
93PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98683807
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98429947
95TRIM28_21343339_ChIP-Seq_HEK293_Human0.98182620
96ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98032638
97P53_22387025_ChIP-Seq_ESCs_Mouse0.97588771
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97224766
99* PRDM14_20953172_ChIP-Seq_ESCs_Human0.97070984
100BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96476476
101AHR_22903824_ChIP-Seq_MCF-7_Human0.95217466
102FLI1_21867929_ChIP-Seq_TH2_Mouse0.95031597
103FUS_26573619_Chip-Seq_HEK293_Human0.94244394
104KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93666485
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92496827
106ESR1_20079471_ChIP-ChIP_T-47D_Human0.92313279
107* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92289539
108ERG_21242973_ChIP-ChIP_JURKAT_Human0.91974918
109STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.91046132
110CMYC_18555785_Chip-Seq_ESCs_Mouse0.90765158
111KDM2B_26808549_Chip-Seq_REH_Human0.90681387
112LXR_22292898_ChIP-Seq_THP-1_Human0.90471298
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90353507
114EZH2_27294783_Chip-Seq_NPCs_Mouse0.90224269
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.89928977
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89027107
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88814760
118DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88701079
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.84260912
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.83806089
121* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83576225
122ZNF263_19887448_ChIP-Seq_K562_Human0.81341503
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81028463
124AR_21572438_ChIP-Seq_LNCaP_Human0.79423113
125* GATA1_19941826_ChIP-Seq_K562_Human0.79242589
126ISL1_27105846_Chip-Seq_CPCs_Mouse0.79030477
127* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78958245
128CDX2_20551321_ChIP-Seq_CACO-2_Human0.78613186
129* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78582708
130KDM2B_26808549_Chip-Seq_DND41_Human0.78425271
131DROSHA_22980978_ChIP-Seq_HELA_Human0.78267450
132ZFP281_18757296_ChIP-ChIP_E14_Mouse0.76577909
133AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76277169
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74839750
135KDM2B_26808549_Chip-Seq_JURKAT_Human0.74134288
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74006630
137* TBX20_22328084_ChIP-Seq_HEART_Mouse0.73936569
138* TBX20_22080862_ChIP-Seq_HEART_Mouse0.73936569
139EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.73121419
140P300_27058665_Chip-Seq_ZR-75-30cells_Human0.72860623
141* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71869945
142BCAT_22108803_ChIP-Seq_LS180_Human0.71026625
143ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.69929653
144DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.69863101
145HTT_18923047_ChIP-ChIP_STHdh_Human0.69668517
146NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69642910
147NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69642910
148FOXA1_25552417_ChIP-Seq_VCAP_Human0.68329801
149PIAS1_25552417_ChIP-Seq_VCAP_Human0.68133088
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.66846863
151PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.66667505
152GATA1_22025678_ChIP-Seq_K562_Human0.66015530
153* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.65464092
154* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.65453218
155SOX2_21211035_ChIP-Seq_LN229_Gbm0.65440600
156SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.65229303
157FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65009820
158MTF2_20144788_ChIP-Seq_MESCs_Mouse0.64191373
159CREB1_26743006_Chip-Seq_LNCaP_Human0.63903905
160GATA4_25053715_ChIP-Seq_YYC3_Human0.63639703
161FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.63408231
162* GATA2_19941826_ChIP-Seq_K562_Human0.62367758
163* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.62112607
164* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.61436235
165AR_19668381_ChIP-Seq_PC3_Human0.60793119
166SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.60688566
167RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.60101076
168NR3C1_23031785_ChIP-Seq_PC12_Mouse0.59971815
169GATA2_21666600_ChIP-Seq_HMVEC_Human0.59616478
170EP300_21415370_ChIP-Seq_HL-1_Mouse0.58838456
171ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.58834080
172EZH2_27294783_Chip-Seq_ESCs_Mouse0.58508982
173* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.58434397
174SOX9_24532713_ChIP-Seq_HFSC_Mouse0.58417509
175CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.58305041
176* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.58250605

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.74250970
2MP0005360_urolithiasis7.12786458
3MP0005085_abnormal_gallbladder_physiolo5.85190710
4MP0005365_abnormal_bile_salt5.72350484
5MP0008875_abnormal_xenobiotic_pharmacok4.75938487
6MP0003252_abnormal_bile_duct3.94688524
7MP0010329_abnormal_lipoprotein_level3.56261282
8MP0005083_abnormal_biliary_tract3.38479108
9MP0004270_analgesia3.31917553
10MP0003880_abnormal_central_pattern3.19614098
11MP0004859_abnormal_synaptic_plasticity3.06870174
12MP0009840_abnormal_foam_cell3.06198798
13MP0003806_abnormal_nucleotide_metabolis2.87988766
14MP0003787_abnormal_imprinting2.85945689
15MP0009046_muscle_twitch2.75855673
16MP0003635_abnormal_synaptic_transmissio2.69076882
17MP0003195_calcinosis2.64953051
18MP0005332_abnormal_amino_acid2.48057812
19MP0002272_abnormal_nervous_system2.43998100
20MP0003122_maternal_imprinting2.36917267
21MP0001984_abnormal_olfaction2.35850520
22MP0009745_abnormal_behavioral_response2.31637796
23MP0002064_seizures2.30601829
24MP0003191_abnormal_cellular_cholesterol2.30212877
25MP0002063_abnormal_learning/memory/cond2.27696306
26MP0002735_abnormal_chemical_nociception2.21665905
27MP0001666_abnormal_nutrient_absorption2.18285797
28MP0001968_abnormal_touch/_nociception2.17950580
29MP0002118_abnormal_lipid_homeostasis2.14769784
30MP0001486_abnormal_startle_reflex2.13369622
31MP0005423_abnormal_somatic_nervous2.07514978
32MP0000609_abnormal_liver_physiology2.06802586
33MP0002138_abnormal_hepatobiliary_system1.95690113
34MP0002734_abnormal_mechanical_nocicepti1.95365578
35MP0002572_abnormal_emotion/affect_behav1.91791116
36MP0004019_abnormal_vitamin_homeostasis1.90997126
37MP0002736_abnormal_nociception_after1.85977959
38MP0003868_abnormal_feces_composition1.76761580
39MP0001986_abnormal_taste_sensitivity1.75784644
40MP0006276_abnormal_autonomic_nervous1.75686237
41MP0001501_abnormal_sleep_pattern1.71934507
42MP0002067_abnormal_sensory_capabilities1.71664265
43MP0002638_abnormal_pupillary_reflex1.71355615
44MP0001970_abnormal_pain_threshold1.71176882
45MP0004742_abnormal_vestibular_system1.69828447
46MP0004142_abnormal_muscle_tone1.68946179
47MP0001440_abnormal_grooming_behavior1.66642486
48MP0003705_abnormal_hypodermis_morpholog1.61389943
49MP0003879_abnormal_hair_cell1.61301260
50MP0008569_lethality_at_weaning1.59456485
51MP0002733_abnormal_thermal_nociception1.58391505
52MP0005319_abnormal_enzyme/_coenzyme1.55741674
53MP0000604_amyloidosis1.52465774
54MP0001188_hyperpigmentation1.47432295
55MP0005386_behavior/neurological_phenoty1.46663359
56MP0004924_abnormal_behavior1.46663359
57MP0002557_abnormal_social/conspecific_i1.46269348
58MP0010368_abnormal_lymphatic_system1.43605817
59MP0005584_abnormal_enzyme/coenzyme_acti1.39662571
60MP0003690_abnormal_glial_cell1.36730461
61MP0002822_catalepsy1.31729349
62MP0001502_abnormal_circadian_rhythm1.28583317
63MP0005646_abnormal_pituitary_gland1.28089677
64MP0005670_abnormal_white_adipose1.26440369
65MP0008877_abnormal_DNA_methylation1.25108698
66MP0005451_abnormal_body_composition1.24898428
67MP0004130_abnormal_muscle_cell1.22375365
68MP0004811_abnormal_neuron_physiology1.21818580
69MP0002184_abnormal_innervation1.20571811
70MP0003121_genomic_imprinting1.20526809
71MP0009643_abnormal_urine_homeostasis1.18752438
72MP0008961_abnormal_basal_metabolism1.18636190
73MP0003631_nervous_system_phenotype1.16753076
74MP0005551_abnormal_eye_electrophysiolog1.15883558
75MP0002229_neurodegeneration1.14334378
76MP0000465_gastrointestinal_hemorrhage1.13099875
77MP0002882_abnormal_neuron_morphology1.12103321
78MP0003656_abnormal_erythrocyte_physiolo1.12089405
79MP0004043_abnormal_pH_regulation1.11563400
80MP0003329_amyloid_beta_deposits1.10292170
81MP0002102_abnormal_ear_morphology1.07082891
82MP0000598_abnormal_liver_morphology1.06077892
83MP0002254_reproductive_system_inflammat1.05517528
84MP0003303_peritoneal_inflammation1.04934695
85MP0002653_abnormal_ependyma_morphology1.02893361
86MP0002066_abnormal_motor_capabilities/c1.00330558
87MP0003724_increased_susceptibility_to1.00141699
88MP0002078_abnormal_glucose_homeostasis0.97450195
89MP0000955_abnormal_spinal_cord0.96633392
90MP0004484_altered_response_of0.96368065
91MP0009780_abnormal_chondrocyte_physiolo0.94972201
92MP0005647_abnormal_sex_gland0.94300898
93MP0003183_abnormal_peptide_metabolism0.93530968
94MP0001764_abnormal_homeostasis0.88695685
95MP0003011_delayed_dark_adaptation0.87948286
96MP0005248_abnormal_Harderian_gland0.87785455
97MP0009763_increased_sensitivity_to0.86541426
98MP0005645_abnormal_hypothalamus_physiol0.85531295
99MP0005409_darkened_coat_color0.82395386
100MP0004085_abnormal_heartbeat0.82199922
101MP0005220_abnormal_exocrine_pancreas0.81528913
102MP0002876_abnormal_thyroid_physiology0.81371087
103MP0005334_abnormal_fat_pad0.80196171
104MP0009642_abnormal_blood_homeostasis0.80022369
105MP0003300_gastrointestinal_ulcer0.79480933
106MP0002971_abnormal_brown_adipose0.77699463
107MP0002332_abnormal_exercise_endurance0.77531026
108MP0002928_abnormal_bile_duct0.74754604
109MP0004885_abnormal_endolymph0.74208450
110MP0004510_myositis0.72106793
111MP0009764_decreased_sensitivity_to0.71400719
112MP0001905_abnormal_dopamine_level0.71262071
113MP0005187_abnormal_penis_morphology0.70357320
114MP0002152_abnormal_brain_morphology0.68707599
115MP0001485_abnormal_pinna_reflex0.68473281
116MP0001756_abnormal_urination0.67109015
117MP0004215_abnormal_myocardial_fiber0.66431070
118MP0005253_abnormal_eye_physiology0.66081325
119MP0005535_abnormal_body_temperature0.65701507
120MP0010234_abnormal_vibrissa_follicle0.65333683
121MP0008872_abnormal_physiological_respon0.64020176
122MP0003172_abnormal_lysosome_physiology0.63885967
123MP0000569_abnormal_digit_pigmentation0.62877499
124MP0005076_abnormal_cell_differentiation0.62658306
125MP0000639_abnormal_adrenal_gland0.62532978
126MP0001915_intracranial_hemorrhage0.60668569
127MP0005408_hypopigmentation0.60655499
128MP0005448_abnormal_energy_balance0.60328862
129MP0008469_abnormal_protein_level0.59206908
130MP0009765_abnormal_xenobiotic_induced0.59031629
131MP0003137_abnormal_impulse_conducting0.58949263
132MP0002837_dystrophic_cardiac_calcinosis0.58300534
133MP0009697_abnormal_copulation0.57969464
134MP0005666_abnormal_adipose_tissue0.55529799
135MP0001879_abnormal_lymphatic_vessel0.55514080
136MP0009672_abnormal_birth_weight0.53308348
137* MP0002136_abnormal_kidney_physiology0.53194299
138MP0000579_abnormal_nail_morphology0.52365117
139MP0000778_abnormal_nervous_system0.51996048
140MP0002090_abnormal_vision0.51169988
141MP0005376_homeostasis/metabolism_phenot0.50613730
142MP0004782_abnormal_surfactant_physiolog0.50417815
143MP0008874_decreased_physiological_sensi0.50250381
144MP0004883_abnormal_blood_vessel0.49996090
145MP0009053_abnormal_anal_canal0.49988252
146MP0003632_abnormal_nervous_system0.49649751
147MP0005636_abnormal_mineral_homeostasis0.49507930
148MP0003953_abnormal_hormone_level0.47081393
149MP0005266_abnormal_metabolism0.45124107
150MP0001881_abnormal_mammary_gland0.45016933
151MP0001661_extended_life_span0.43566561
152MP0004185_abnormal_adipocyte_glucose0.42417811
153MP0005167_abnormal_blood-brain_barrier0.42251136
154MP0002168_other_aberrant_phenotype0.42222940
155MP0005166_decreased_susceptibility_to0.41069270
156MP0001944_abnormal_pancreas_morphology0.40495485
157MP0003186_abnormal_redox_activity0.40400774
158MP0002909_abnormal_adrenal_gland0.39836490
159MP0009115_abnormal_fat_cell0.39777930
160MP0003638_abnormal_response/metabolism_0.38687431
161MP0005375_adipose_tissue_phenotype0.38633814
162MP0005058_abnormal_lysosome_morphology0.38046449
163MP0002970_abnormal_white_adipose0.37694133
164MP0002697_abnormal_eye_size0.37363394
165MP0000230_abnormal_systemic_arterial0.35884445
166MP0003633_abnormal_nervous_system0.35537500
167MP0005197_abnormal_uvea_morphology0.34920966
168MP0000920_abnormal_myelination0.33434376
169MP0002069_abnormal_eating/drinking_beha0.33192616

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.02500992
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.27963151
3Intrahepatic cholestasis (HP:0001406)6.24895431
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.66433382
5Xanthomatosis (HP:0000991)5.59693436
6Prolonged partial thromboplastin time (HP:0003645)5.24351950
7Complement deficiency (HP:0004431)5.19822161
8Hyperlipoproteinemia (HP:0010980)5.04829951
9Hypobetalipoproteinemia (HP:0003563)5.01211751
10Febrile seizures (HP:0002373)4.84154639
11Focal motor seizures (HP:0011153)4.65487212
12Epidermoid cyst (HP:0200040)4.61131065
13Joint hemorrhage (HP:0005261)4.29307455
14Progressive cerebellar ataxia (HP:0002073)4.10221170
15Hyperventilation (HP:0002883)4.02623006
16Action tremor (HP:0002345)3.98162483
17Ketosis (HP:0001946)3.93893121
18Hypolipoproteinemia (HP:0010981)3.92191391
19Atonic seizures (HP:0010819)3.89612166
20Abnormality of the common coagulation pathway (HP:0010990)3.79909496
21Abnormality of complement system (HP:0005339)3.78006478
22Hyperammonemia (HP:0001987)3.77667178
23Epileptic encephalopathy (HP:0200134)3.72426592
24Hypoalphalipoproteinemia (HP:0003233)3.71965160
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.69721526
26Focal seizures (HP:0007359)3.68892224
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.66497417
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.47453402
29Myocardial infarction (HP:0001658)3.44270802
30Hypercholesterolemia (HP:0003124)3.42643009
31Hyperglycinemia (HP:0002154)3.41215632
32Fat malabsorption (HP:0002630)3.35912287
33Myokymia (HP:0002411)3.35597315
34Hypoglycemic coma (HP:0001325)3.33579296
35Polyphagia (HP:0002591)3.30512295
36Absent speech (HP:0001344)3.28500230
37Broad-based gait (HP:0002136)3.25536743
38Dysdiadochokinesis (HP:0002075)3.23632215
39Gaze-evoked nystagmus (HP:0000640)3.21906414
40Conjugated hyperbilirubinemia (HP:0002908)3.17402826
41Systemic lupus erythematosus (HP:0002725)3.10497326
42Ketoacidosis (HP:0001993)3.10443746
43Abnormality of aspartate family amino acid metabolism (HP:0010899)3.09742764
44Abnormality of serine family amino acid metabolism (HP:0010894)3.07964922
45Abnormality of glycine metabolism (HP:0010895)3.07964922
46Abnormality of methionine metabolism (HP:0010901)3.07395835
47Hyperglycinuria (HP:0003108)3.06869977
48Agitation (HP:0000713)3.00004538
49Hypochromic microcytic anemia (HP:0004840)2.95703369
50Hepatocellular carcinoma (HP:0001402)2.90179186
51Hemiparesis (HP:0001269)2.90154470
52Mitral stenosis (HP:0001718)2.88614222
53Glomerulonephritis (HP:0000099)2.88342347
54Dialeptic seizures (HP:0011146)2.81892153
55Abnormality of pyrimidine metabolism (HP:0004353)2.80159962
56Abnormality of the intrinsic pathway (HP:0010989)2.79583779
57Skin nodule (HP:0200036)2.78003804
58Intention tremor (HP:0002080)2.76572357
59Absence seizures (HP:0002121)2.74318157
60Cortical dysplasia (HP:0002539)2.69287913
61Hypoglycemic seizures (HP:0002173)2.69241921
62Drooling (HP:0002307)2.68564707
63Mutism (HP:0002300)2.64928417
64Hyperbilirubinemia (HP:0002904)2.64810176
65Hemiplegia (HP:0002301)2.62259321
66Excessive salivation (HP:0003781)2.60527876
67Limb dystonia (HP:0002451)2.59171693
68Epileptiform EEG discharges (HP:0011182)2.58065407
69EEG with generalized epileptiform discharges (HP:0011198)2.56000526
70Abnormality of nucleobase metabolism (HP:0010932)2.55571078
71Postural instability (HP:0002172)2.55548112
72Truncal ataxia (HP:0002078)2.54584536
73Neurofibrillary tangles (HP:0002185)2.53766654
74Hypsarrhythmia (HP:0002521)2.52040314
75Degeneration of the lateral corticospinal tracts (HP:0002314)2.51883923
76Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.51883923
77Genetic anticipation (HP:0003743)2.49057344
78Spastic diplegia (HP:0001264)2.48386217
79Delayed CNS myelination (HP:0002188)2.44983518
80Back pain (HP:0003418)2.43490975
81Abnormality of purine metabolism (HP:0004352)2.43276636
82Diplopia (HP:0000651)2.43074821
83Abnormality of binocular vision (HP:0011514)2.43074821
84Steatorrhea (HP:0002570)2.41265614
85Ankle clonus (HP:0011448)2.40084460
86Scanning speech (HP:0002168)2.39281134
87Vascular calcification (HP:0004934)2.38604119
88Esophageal varix (HP:0002040)2.37462492
89Abnormal eating behavior (HP:0100738)2.33720356
90Cerebral inclusion bodies (HP:0100314)2.33670711
91Gout (HP:0001997)2.33092270
92Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.31744682
93Recurrent gram-negative bacterial infections (HP:0005420)2.29000451
94Generalized tonic-clonic seizures (HP:0002069)2.28632436
95Widely spaced teeth (HP:0000687)2.24009331
96Prolonged bleeding time (HP:0003010)2.23805745
97Hyperinsulinemic hypoglycemia (HP:0000825)2.23101973
98Abnormality of fatty-acid metabolism (HP:0004359)2.20818351
99Lymphangioma (HP:0100764)2.20467206
100Nephritis (HP:0000123)2.16183226
101Lissencephaly (HP:0001339)2.14726206
102Hemorrhage of the eye (HP:0011885)2.12774453
103Irritability (HP:0000737)2.12541159
104Spastic tetraplegia (HP:0002510)2.11339366
105Postural tremor (HP:0002174)2.11257960
106Pachygyria (HP:0001302)2.09979225
107Urinary bladder sphincter dysfunction (HP:0002839)2.09627927
108Spontaneous abortion (HP:0005268)2.09549792
109Medial flaring of the eyebrow (HP:0010747)2.08917024
110Abnormality of ocular smooth pursuit (HP:0000617)2.08911448
111Hepatoblastoma (HP:0002884)2.06960119
112Impaired smooth pursuit (HP:0007772)2.06077270
113Inability to walk (HP:0002540)2.05369999
114Cardiovascular calcification (HP:0011915)2.04366992
115Gait imbalance (HP:0002141)2.03640885
116Spastic gait (HP:0002064)2.02313698
117Esotropia (HP:0000565)2.01174359
118Turricephaly (HP:0000262)2.00952585
119Amyloidosis (HP:0011034)2.00939357
120Gingival bleeding (HP:0000225)2.00231561
121Abnormal gallbladder morphology (HP:0012437)2.00164963
122Pseudobulbar signs (HP:0002200)1.99986257
123Morphological abnormality of the pyramidal tract (HP:0002062)1.98545547
124Status epilepticus (HP:0002133)1.98314180
125Fair hair (HP:0002286)1.97459773
126Amyotrophic lateral sclerosis (HP:0007354)1.97299707
127Urinary urgency (HP:0000012)1.96022710
128Impaired vibration sensation in the lower limbs (HP:0002166)1.95278433
129Supranuclear gaze palsy (HP:0000605)1.94161263
130Neonatal onset (HP:0003623)1.94007048
131Metabolic acidosis (HP:0001942)1.92321108
132Late onset (HP:0003584)1.91629219
133Dysmetria (HP:0001310)1.91418887
134Focal segmental glomerulosclerosis (HP:0000097)1.91358043
135Cholelithiasis (HP:0001081)1.90247839
136Hyperglycemia (HP:0003074)1.88065892
137Abnormality of serum amino acid levels (HP:0003112)1.88062839
138Upper motor neuron abnormality (HP:0002127)1.87912149
139Ulnar claw (HP:0001178)1.86718932
140Sleep apnea (HP:0010535)1.85800350
141Blue irides (HP:0000635)1.85628830
142Congenital stationary night blindness (HP:0007642)1.83914899
143Glomerulosclerosis (HP:0000096)1.82730996
144Abnormality of the corticospinal tract (HP:0002492)1.82187382
145Hypothermia (HP:0002045)1.80864917
146Purpura (HP:0000979)1.80040850
147Protruding tongue (HP:0010808)1.77911587
148Sensorimotor neuropathy (HP:0007141)1.77591467
149Intellectual disability, progressive (HP:0006887)1.77285267
150Acanthocytosis (HP:0001927)1.76697122
151Arthropathy (HP:0003040)1.76691026
152Nephrogenic diabetes insipidus (HP:0009806)1.76565519
153Polycythemia (HP:0001901)1.75903505
154Abnormal enzyme/coenzyme activity (HP:0012379)1.75872158
155Hydroxyprolinuria (HP:0003080)1.75644494
156Abnormality of proline metabolism (HP:0010907)1.75644494
157Menorrhagia (HP:0000132)1.75338099
158Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75165540
159Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74820167
160Global brain atrophy (HP:0002283)1.74541422
161Abnormality of endocrine pancreas physiology (HP:0012093)1.74248065
162Abnormality of the pancreatic islet cells (HP:0006476)1.74248065
163Hypophosphatemic rickets (HP:0004912)1.74206032
164Polydipsia (HP:0001959)1.74176861
165Abnormal drinking behavior (HP:0030082)1.74176861
166Death in childhood (HP:0003819)1.73962075
167Rickets (HP:0002748)1.73950308
168Lower limb muscle weakness (HP:0007340)1.73148224
169Thrombophlebitis (HP:0004418)1.72729384
170Syncope (HP:0001279)1.72276288
171Hypoplasia of the corpus callosum (HP:0002079)1.72272518
172Increased circulating renin level (HP:0000848)1.72123716
173Symptomatic seizures (HP:0011145)1.70615440
174Generalized hypopigmentation of hair (HP:0011358)1.69175234
175Exotropia (HP:0000577)1.69140085
176Enlarged kidneys (HP:0000105)1.68795620
177Intellectual disability, severe (HP:0010864)1.68572357
178Progressive inability to walk (HP:0002505)1.67559940
179Abnormality of midbrain morphology (HP:0002418)1.65208505
180Molar tooth sign on MRI (HP:0002419)1.65208505
181Hip dysplasia (HP:0001385)1.64976068
182Fetal akinesia sequence (HP:0001989)1.64624888
183Ventricular fibrillation (HP:0001663)1.64010676
184Impaired vibratory sensation (HP:0002495)1.63864639
185Peripheral demyelination (HP:0011096)1.61000669
186Stroke (HP:0001297)1.60259798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.65105476
2CASK3.51085619
3SIK13.16273033
4ERN13.14375395
5FGFR42.93403944
6MAP3K102.48886567
7FGFR22.37102247
8BCKDK2.36583615
9CAMK1D2.35789232
10CAMK1G2.34678471
11NTRK32.32209273
12INSRR2.19630395
13TRIB32.14158543
14PINK11.95396654
15PTK61.91508067
16ERBB41.90986669
17PKN21.74111404
18EPHB11.73367071
19MAP2K71.72517084
20TAOK31.65196713
21MAP2K41.56360377
22RIPK11.40378870
23SIK21.35017994
24MAP3K91.32680412
25TRIM281.30821009
26DYRK1B1.30451054
27FES1.23561103
28AKT31.23114804
29NTRK21.22363682
30LATS11.21819941
31DYRK21.21011754
32MAP4K21.20469295
33CDK61.14177574
34PKN11.13996883
35PRKCG1.13605738
36DAPK21.12590857
37TAOK11.12360892
38BCR1.12233335
39MINK11.11918694
40FGFR31.09886609
41CAMKK21.09481024
42SGK31.07301130
43PRKCZ1.07288498
44CDK121.04978691
45RET1.04529917
46FRK1.03623109
47CDK51.02740563
48PTK2B1.01801410
49PDGFRA1.01616931
50ERBB20.97880120
51MAPK110.97316601
52MAP3K70.97308802
53MAPK150.97135707
54EPHA40.96352359
55PHKG10.96171026
56PHKG20.96171026
57MAPK120.95919526
58GSK3A0.95628624
59EPHB20.95413722
60ICK0.95283544
61WNK30.95142882
62SIK30.92994264
63PAK60.91979063
64MAP3K40.91882192
65TNK20.90455633
66MTOR0.88784905
67TYK20.88657823
68JAK20.88087754
69SGK2230.87790985
70SGK4940.87790985
71BLK0.87204474
72CSNK1G20.86408561
73GRK60.85581849
74PRKAA20.84347750
75PRKCH0.83734985
76GRK50.83029882
77CSNK1A1L0.82411678
78ADRBK20.81778733
79PRKAA10.81150674
80CAMK2A0.81117667
81TYRO30.80275316
82TNIK0.79900751
83RIPK40.77742984
84SGK10.77228829
85PRKCE0.76905089
86PAK30.75447969
87TGFBR20.75045948
88SGK20.75024289
89FER0.74177226
90CSNK1G10.73879828
91PTK20.72660491
92PLK20.71626961
93FGR0.71445070
94PRKD10.71410957
95TIE10.70214278
96MAP3K120.69969143
97CSNK1G30.69174058
98MAP3K20.69161484
99GRK10.68611905
100BRD40.68270686
101PRKG10.68144793
102MATK0.67002264
103MAPK40.66584343
104CAMKK10.66437838
105LATS20.65191760
106EGFR0.64692703
107MAP3K110.64353315
108CAMK2B0.64195237
109CSK0.63936002
110EPHA30.62889611
111SYK0.62721376
112CAMK40.62556547
113PDGFRB0.62073911
114PRKACG0.61694368
115JAK10.60596005
116UHMK10.58925225
117DYRK1A0.58776493
118MAPK70.57213571
119BMX0.55516750
120TXK0.55505181
121PRKACA0.53975058
122ABL20.53804922
123RPS6KA20.53576612
124CSF1R0.52188720
125PDK10.49153512
126GRK70.45842096
127YES10.43404457
128MAPK130.43177482
129MAP2K10.42600954
130IRAK40.42475885
131NTRK10.42396597
132MAP4K10.42003707
133HIPK20.41451230
134STK110.41030107
135STK380.40903884
136ABL10.40854159
137MARK30.40730026
138WNK10.40410770
139MARK20.39736092
140MET0.39705423
141MAP3K10.39520710
142MAP2K60.39300961
143PRKCQ0.39136634
144WNK40.38734871
145RPS6KA30.38490953
146HCK0.38053234
147* CSNK1D0.37960111
148ERBB30.37801861
149FYN0.36896544
150KSR10.35424754

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.25996567
2Nitrogen metabolism_Homo sapiens_hsa009103.98079909
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.53655433
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24700980
5Arginine biosynthesis_Homo sapiens_hsa002203.07379270
6Nicotine addiction_Homo sapiens_hsa050332.82583700
7Complement and coagulation cascades_Homo sapiens_hsa046102.81822547
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.77776971
9Tryptophan metabolism_Homo sapiens_hsa003802.71252775
10Butanoate metabolism_Homo sapiens_hsa006502.41863113
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.28880899
12Fatty acid degradation_Homo sapiens_hsa000712.24150436
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22813816
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15486953
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.13176610
16Circadian entrainment_Homo sapiens_hsa047132.11298319
17Glutamatergic synapse_Homo sapiens_hsa047242.10981602
18Morphine addiction_Homo sapiens_hsa050321.95383988
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.95045959
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93792668
21Long-term depression_Homo sapiens_hsa047301.92108619
22Staphylococcus aureus infection_Homo sapiens_hsa051501.88666530
23PPAR signaling pathway_Homo sapiens_hsa033201.88230003
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.80348485
25Peroxisome_Homo sapiens_hsa041461.79210577
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.78454879
27Caffeine metabolism_Homo sapiens_hsa002321.75644393
28Fatty acid metabolism_Homo sapiens_hsa012121.70972373
29Histidine metabolism_Homo sapiens_hsa003401.70971308
30Bile secretion_Homo sapiens_hsa049761.69547592
31Dopaminergic synapse_Homo sapiens_hsa047281.68998718
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.67130115
33Synaptic vesicle cycle_Homo sapiens_hsa047211.62607346
34Propanoate metabolism_Homo sapiens_hsa006401.57262664
35Chemical carcinogenesis_Homo sapiens_hsa052041.55830124
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50502022
37Serotonergic synapse_Homo sapiens_hsa047261.50202556
38beta-Alanine metabolism_Homo sapiens_hsa004101.47890589
39Retinol metabolism_Homo sapiens_hsa008301.46158965
40Insulin secretion_Homo sapiens_hsa049111.45560799
41Long-term potentiation_Homo sapiens_hsa047201.45295978
42Amphetamine addiction_Homo sapiens_hsa050311.44254337
43Phenylalanine metabolism_Homo sapiens_hsa003601.38258593
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.36372271
45Lysine degradation_Homo sapiens_hsa003101.34694384
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.34055328
47Taste transduction_Homo sapiens_hsa047421.33984746
48Renin secretion_Homo sapiens_hsa049241.32736402
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31177459
50ABC transporters_Homo sapiens_hsa020101.30021982
51Selenocompound metabolism_Homo sapiens_hsa004501.29005414
52Steroid biosynthesis_Homo sapiens_hsa001001.26593316
53Circadian rhythm_Homo sapiens_hsa047101.25757492
54Phototransduction_Homo sapiens_hsa047441.22342655
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20620331
56Tyrosine metabolism_Homo sapiens_hsa003501.20251562
57Collecting duct acid secretion_Homo sapiens_hsa049661.17883802
58Cholinergic synapse_Homo sapiens_hsa047251.12903259
59Salivary secretion_Homo sapiens_hsa049701.10562412
60Starch and sucrose metabolism_Homo sapiens_hsa005001.10533079
61Cocaine addiction_Homo sapiens_hsa050301.09211815
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07525629
63Gastric acid secretion_Homo sapiens_hsa049711.07101238
64Fat digestion and absorption_Homo sapiens_hsa049751.03690791
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01607501
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01433053
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00903573
68Pyruvate metabolism_Homo sapiens_hsa006200.98541315
69Fatty acid elongation_Homo sapiens_hsa000620.96214990
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94938427
71Sulfur metabolism_Homo sapiens_hsa009200.94388762
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93419610
73Calcium signaling pathway_Homo sapiens_hsa040200.92317252
74Oxytocin signaling pathway_Homo sapiens_hsa049210.90886228
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84975359
76cAMP signaling pathway_Homo sapiens_hsa040240.82968042
77Gap junction_Homo sapiens_hsa045400.78793855
78Ether lipid metabolism_Homo sapiens_hsa005650.78171879
79Biosynthesis of amino acids_Homo sapiens_hsa012300.78158054
80Platelet activation_Homo sapiens_hsa046110.77879092
81Regulation of autophagy_Homo sapiens_hsa041400.77027242
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.76469816
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76448992
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.74947830
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73730340
86GnRH signaling pathway_Homo sapiens_hsa049120.72859886
87Estrogen signaling pathway_Homo sapiens_hsa049150.72059728
88Olfactory transduction_Homo sapiens_hsa047400.69886758
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.68399818
90Carbon metabolism_Homo sapiens_hsa012000.68055698
91Glycerolipid metabolism_Homo sapiens_hsa005610.66760569
92Ras signaling pathway_Homo sapiens_hsa040140.65456140
93Arginine and proline metabolism_Homo sapiens_hsa003300.65419484
94Choline metabolism in cancer_Homo sapiens_hsa052310.65321607
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64407235
96Insulin resistance_Homo sapiens_hsa049310.61993090
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61865646
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60273135
99Prion diseases_Homo sapiens_hsa050200.59900242
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.59669312
101Pancreatic secretion_Homo sapiens_hsa049720.57104166
102Folate biosynthesis_Homo sapiens_hsa007900.56850797
103Phagosome_Homo sapiens_hsa041450.55751275
104Fatty acid biosynthesis_Homo sapiens_hsa000610.55578157
105MAPK signaling pathway_Homo sapiens_hsa040100.54295240
106Pertussis_Homo sapiens_hsa051330.53204516
107Chemokine signaling pathway_Homo sapiens_hsa040620.52970392
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52697573
109Rap1 signaling pathway_Homo sapiens_hsa040150.51061666
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50651104
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50523697
112Vitamin digestion and absorption_Homo sapiens_hsa049770.48340152
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48041486
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.46729646
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.44420776
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44210042
117Osteoclast differentiation_Homo sapiens_hsa043800.43283215
118Arachidonic acid metabolism_Homo sapiens_hsa005900.42441115
119ErbB signaling pathway_Homo sapiens_hsa040120.42287030
120Type I diabetes mellitus_Homo sapiens_hsa049400.41791259
121Endocytosis_Homo sapiens_hsa041440.41356689
122Type II diabetes mellitus_Homo sapiens_hsa049300.41099750
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39707902
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.35617049
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35544261
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35475814
127Sulfur relay system_Homo sapiens_hsa041220.34530452
128AMPK signaling pathway_Homo sapiens_hsa041520.33989978
129Vitamin B6 metabolism_Homo sapiens_hsa007500.33490697
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29692353
131Glucagon signaling pathway_Homo sapiens_hsa049220.28058305
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25482158
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24999069
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21226154
135Insulin signaling pathway_Homo sapiens_hsa049100.18583682
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16611423
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12907901
138B cell receptor signaling pathway_Homo sapiens_hsa046620.12645958
139Endometrial cancer_Homo sapiens_hsa052130.11819085
140Linoleic acid metabolism_Homo sapiens_hsa005910.11433885
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.10627245
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.10534846
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.09577450
144Dorso-ventral axis formation_Homo sapiens_hsa043200.08668150
145Renal cell carcinoma_Homo sapiens_hsa052110.08463546
146Metabolic pathways_Homo sapiens_hsa011000.08208930
147mTOR signaling pathway_Homo sapiens_hsa041500.07273830
148Amoebiasis_Homo sapiens_hsa051460.07263859
149Non-small cell lung cancer_Homo sapiens_hsa052230.06611329
150Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.06221029
151Axon guidance_Homo sapiens_hsa043600.05940369
152Glutathione metabolism_Homo sapiens_hsa004800.05608535
153GABAergic synapse_Homo sapiens_hsa047270.04323478
154Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.04046353
155One carbon pool by folate_Homo sapiens_hsa006700.03668468
156Pentose phosphate pathway_Homo sapiens_hsa000300.02664708
157Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.02273301
158Ovarian steroidogenesis_Homo sapiens_hsa049130.02177730
159Lysosome_Homo sapiens_hsa041420.01477702
160Notch signaling pathway_Homo sapiens_hsa04330-0.0155934
161Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0118673
162Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0028120

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