

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | locomotory exploration behavior (GO:0035641) | 5.90653931 |
| 2 | synaptic vesicle maturation (GO:0016188) | 5.45513054 |
| 3 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.01696575 |
| 4 | layer formation in cerebral cortex (GO:0021819) | 4.87869954 |
| 5 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.86237764 |
| 6 | vocalization behavior (GO:0071625) | 4.80168370 |
| 7 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.63654970 |
| 8 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.54827463 |
| 9 | sodium ion export (GO:0071436) | 4.54512967 |
| 10 | glutamate secretion (GO:0014047) | 4.30006611 |
| 11 | cellular potassium ion homeostasis (GO:0030007) | 4.29405575 |
| 12 | synaptic vesicle exocytosis (GO:0016079) | 4.27199460 |
| 13 | exploration behavior (GO:0035640) | 4.19135797 |
| 14 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.12827910 |
| 15 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.12430613 |
| 16 | regulation of synapse structural plasticity (GO:0051823) | 4.09124570 |
| 17 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.08214610 |
| 18 | gamma-aminobutyric acid transport (GO:0015812) | 4.05122198 |
| 19 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 4.03421618 |
| 20 | axon ensheathment in central nervous system (GO:0032291) | 4.02224690 |
| 21 | central nervous system myelination (GO:0022010) | 4.02224690 |
| 22 | cell communication by electrical coupling (GO:0010644) | 3.94087247 |
| 23 | neurotransmitter secretion (GO:0007269) | 3.90410631 |
| 24 | dendritic spine morphogenesis (GO:0060997) | 3.87233790 |
| 25 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.79448371 |
| 26 | neuron cell-cell adhesion (GO:0007158) | 3.78272339 |
| 27 | cerebellar granule cell differentiation (GO:0021707) | 3.76686588 |
| 28 | protein localization to synapse (GO:0035418) | 3.74544681 |
| 29 | proline transport (GO:0015824) | 3.66432289 |
| 30 | dendrite morphogenesis (GO:0048813) | 3.65081412 |
| 31 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.64700873 |
| 32 | regulation of synaptic vesicle transport (GO:1902803) | 3.56869142 |
| 33 | positive regulation of synapse maturation (GO:0090129) | 3.56232548 |
| 34 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.53597236 |
| 35 | synaptic transmission, glutamatergic (GO:0035249) | 3.44196395 |
| 36 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.43729297 |
| 37 | activation of protein kinase A activity (GO:0034199) | 3.42764300 |
| 38 | neuronal action potential propagation (GO:0019227) | 3.41126857 |
| 39 | potassium ion import (GO:0010107) | 3.40595906 |
| 40 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.40478869 |
| 41 | neuromuscular process controlling balance (GO:0050885) | 3.39287800 |
| 42 | glutamate receptor signaling pathway (GO:0007215) | 3.38047067 |
| 43 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.35370842 |
| 44 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.29715493 |
| 45 | long-term memory (GO:0007616) | 3.28056100 |
| 46 | auditory behavior (GO:0031223) | 3.25800500 |
| 47 | postsynaptic membrane organization (GO:0001941) | 3.25790490 |
| 48 | establishment of nucleus localization (GO:0040023) | 3.23176453 |
| 49 | innervation (GO:0060384) | 3.20176171 |
| 50 | cerebellar Purkinje cell layer development (GO:0021680) | 3.16551778 |
| 51 | cell migration in hindbrain (GO:0021535) | 3.16457597 |
| 52 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.13725366 |
| 53 | glycine transport (GO:0015816) | 3.12609411 |
| 54 | potassium ion homeostasis (GO:0055075) | 3.11432845 |
| 55 | positive regulation of dendritic spine development (GO:0060999) | 3.11028759 |
| 56 | response to auditory stimulus (GO:0010996) | 3.09301342 |
| 57 | response to pheromone (GO:0019236) | 3.07357241 |
| 58 | neurotransmitter transport (GO:0006836) | 3.06131932 |
| 59 | neuron recognition (GO:0008038) | 3.03086738 |
| 60 | neuron-neuron synaptic transmission (GO:0007270) | 3.01675653 |
| 61 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.00591598 |
| 62 | axonal fasciculation (GO:0007413) | 3.00122349 |
| 63 | L-amino acid import (GO:0043092) | 2.96599350 |
| 64 | synaptic vesicle endocytosis (GO:0048488) | 2.95501735 |
| 65 | cellular sodium ion homeostasis (GO:0006883) | 2.95391068 |
| 66 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.94576379 |
| 67 | positive regulation of membrane potential (GO:0045838) | 2.92591742 |
| 68 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.91456138 |
| 69 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.91383757 |
| 70 | cell communication involved in cardiac conduction (GO:0086065) | 2.90991952 |
| 71 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.90510853 |
| 72 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.88885401 |
| 73 | membrane repolarization (GO:0086009) | 2.87972095 |
| 74 | regulation of ARF protein signal transduction (GO:0032012) | 2.87560855 |
| 75 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.85796267 |
| 76 | regulation of neurotransmitter levels (GO:0001505) | 2.84030213 |
| 77 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.83170245 |
| 78 | regulation of synaptic plasticity (GO:0048167) | 2.81682864 |
| 79 | cell differentiation in hindbrain (GO:0021533) | 2.80423398 |
| 80 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.79724636 |
| 81 | regulation of postsynaptic membrane potential (GO:0060078) | 2.78909407 |
| 82 | prepulse inhibition (GO:0060134) | 2.77611739 |
| 83 | synapse organization (GO:0050808) | 2.76893300 |
| 84 | long-term synaptic potentiation (GO:0060291) | 2.75664903 |
| 85 | regulation of neurotransmitter secretion (GO:0046928) | 2.74998506 |
| 86 | astrocyte development (GO:0014002) | 2.74402395 |
| 87 | transmission of nerve impulse (GO:0019226) | 2.74295271 |
| 88 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.73512451 |
| 89 | alanine transport (GO:0032328) | 2.73213890 |
| 90 | membrane depolarization during action potential (GO:0086010) | 2.72532906 |
| 91 | synapse assembly (GO:0007416) | 2.71039035 |
| 92 | positive regulation of dendrite development (GO:1900006) | 2.70618446 |
| 93 | chondroitin sulfate catabolic process (GO:0030207) | 2.69868072 |
| 94 | neuromuscular process controlling posture (GO:0050884) | 2.69044948 |
| 95 | neuronal ion channel clustering (GO:0045161) | 2.68881939 |
| 96 | amino acid import (GO:0043090) | 2.68837528 |
| 97 | dendritic spine organization (GO:0097061) | 2.67124685 |
| 98 | negative regulation of catenin import into nucleus (GO:0035414) | 2.66354615 |
| 99 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.65173184 |
| 100 | neuromuscular process (GO:0050905) | 2.64952538 |
| 101 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.62605842 |
| 102 | vesicle transport along microtubule (GO:0047496) | 2.61517433 |
| 103 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.60054116 |
| 104 | membrane hyperpolarization (GO:0060081) | 2.59930628 |
| 105 | mating behavior (GO:0007617) | 2.59610324 |
| 106 | regulation of neurotransmitter transport (GO:0051588) | 2.59284000 |
| 107 | clathrin coat assembly (GO:0048268) | 2.59251370 |
| 108 | presynaptic membrane assembly (GO:0097105) | 2.58745538 |
| 109 | regulation of synapse maturation (GO:0090128) | 2.57570821 |
| 110 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.57076541 |
| 111 | myelination in peripheral nervous system (GO:0022011) | 2.56206366 |
| 112 | peripheral nervous system axon ensheathment (GO:0032292) | 2.56206366 |
| 113 | astrocyte differentiation (GO:0048708) | 2.54896834 |
| 114 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.54655645 |
| 115 | acidic amino acid transport (GO:0015800) | 2.51056162 |
| 116 | presynaptic membrane organization (GO:0097090) | 2.50506470 |
| 117 | regulation of cholesterol biosynthetic process (GO:0045540) | 2.49869594 |
| 118 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 2.49225742 |
| 119 | protein retention in ER lumen (GO:0006621) | 2.47167185 |
| 120 | protein targeting to plasma membrane (GO:0072661) | 2.46413469 |
| 121 | cell-cell junction maintenance (GO:0045217) | 2.46275341 |
| 122 | peptidyl-tyrosine autophosphorylation (GO:0038083) | 2.45268708 |
| 123 | neurotransmitter uptake (GO:0001504) | 2.44877226 |
| 124 | negative regulation of dendrite morphogenesis (GO:0050774) | 2.43170019 |
| 125 | semaphorin-plexin signaling pathway (GO:0071526) | 2.40066198 |
| 126 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.37034838 |
| 127 | myelin maintenance (GO:0043217) | 2.35481490 |
| 128 | lung epithelium development (GO:0060428) | 2.35261972 |
| 129 | neuron projection regeneration (GO:0031102) | 2.34828383 |
| 130 | cell volume homeostasis (GO:0006884) | 2.33861644 |
| 131 | adherens junction assembly (GO:0034333) | 2.33751631 |
| 132 | membrane assembly (GO:0071709) | 2.32067456 |
| 133 | dermatan sulfate metabolic process (GO:0030205) | 2.31239212 |
| 134 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.28745401 |
| 135 | regulation of early endosome to late endosome transport (GO:2000641) | 2.28654035 |
| 136 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 2.27478951 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.20807957 |
| 2 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.93320657 |
| 3 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.82865503 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.78685292 |
| 5 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.77964768 |
| 6 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.77964768 |
| 7 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.65240097 |
| 8 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.55097652 |
| 9 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.44962243 |
| 10 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.43937997 |
| 11 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.42142345 |
| 12 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.41773771 |
| 13 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.40306009 |
| 14 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.34577540 |
| 15 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.33920620 |
| 16 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.26441461 |
| 17 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.26426930 |
| 18 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.25478153 |
| 19 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.25220001 |
| 20 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.18437167 |
| 21 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.18172629 |
| 22 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.17855202 |
| 23 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.15748852 |
| 24 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.10106237 |
| 25 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.95524652 |
| 26 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.95494507 |
| 27 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.94176515 |
| 28 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.93335421 |
| 29 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.90450534 |
| 30 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.85091402 |
| 31 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.83745752 |
| 32 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.75310150 |
| 33 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.72495179 |
| 34 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.70657671 |
| 35 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.68516198 |
| 36 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.66268367 |
| 37 | KDM2B_26808549_Chip-Seq_K562_Human | 1.65700860 |
| 38 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.62438783 |
| 39 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.51318573 |
| 40 | * RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.50420711 |
| 41 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.48504544 |
| 42 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.46028697 |
| 43 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.45822179 |
| 44 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.43248354 |
| 45 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.42358162 |
| 46 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.42166451 |
| 47 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.41535669 |
| 48 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.41141602 |
| 49 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.40046959 |
| 50 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.39384405 |
| 51 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.37974711 |
| 52 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.37356182 |
| 53 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.37011958 |
| 54 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.36930540 |
| 55 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.35630466 |
| 56 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.32459012 |
| 57 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.28058809 |
| 58 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.27691078 |
| 59 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.27591584 |
| 60 | AR_19668381_ChIP-Seq_PC3_Human | 1.26525803 |
| 61 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.26303813 |
| 62 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.24999163 |
| 63 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.24442496 |
| 64 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.23354588 |
| 65 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.23015135 |
| 66 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.22253825 |
| 67 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.21366186 |
| 68 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.20799389 |
| 69 | * RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.20569489 |
| 70 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.19810670 |
| 71 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.19275369 |
| 72 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.19062776 |
| 73 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.18621313 |
| 74 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.17072809 |
| 75 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.16669521 |
| 76 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.15949914 |
| 77 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.14936382 |
| 78 | * TP53_23651856_ChIP-Seq_MEFs_Mouse | 1.14119297 |
| 79 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.13992302 |
| 80 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.12953527 |
| 81 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.12948893 |
| 82 | P68_20966046_ChIP-Seq_HELA_Human | 1.12404278 |
| 83 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.12007319 |
| 84 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.10781990 |
| 85 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.09498104 |
| 86 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.09335240 |
| 87 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.09135038 |
| 88 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.09014014 |
| 89 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.07652898 |
| 90 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.06824585 |
| 91 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.05662061 |
| 92 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.04259792 |
| 93 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.03229469 |
| 94 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.02846920 |
| 95 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.02711196 |
| 96 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.02634134 |
| 97 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.02607356 |
| 98 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.02336331 |
| 99 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.02298553 |
| 100 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.01895887 |
| 101 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.01596426 |
| 102 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.00847366 |
| 103 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.00599200 |
| 104 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.00568648 |
| 105 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.99621759 |
| 106 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.99596146 |
| 107 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.99428430 |
| 108 | * SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.97848418 |
| 109 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.97516664 |
| 110 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.97240469 |
| 111 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.96652642 |
| 112 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.96053856 |
| 113 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.96053856 |
| 114 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.95319664 |
| 115 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.95187505 |
| 116 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.93291027 |
| 117 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.93237504 |
| 118 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.92822660 |
| 119 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.92592658 |
| 120 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.91879405 |
| 121 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.91573598 |
| 122 | RXR_22108803_ChIP-Seq_LS180_Human | 0.91403490 |
| 123 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.90997913 |
| 124 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.90748322 |
| 125 | STAT3_23295773_ChIP-Seq_U87_Human | 0.90534684 |
| 126 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.90511842 |
| 127 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.90448978 |
| 128 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.89918030 |
| 129 | AR_25329375_ChIP-Seq_VCAP_Human | 0.89281242 |
| 130 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.89231258 |
| 131 | * SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.87439952 |
| 132 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.87301913 |
| 133 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.87245158 |
| 134 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 0.87178390 |
| 135 | TP53_16413492_ChIP-PET_HCT116_Human | 0.87167209 |
| 136 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.87118597 |
| 137 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.85345958 |
| 138 | * TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.84667550 |
| 139 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.84013635 |
| 140 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.83659180 |
| 141 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.81346232 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.93944562 |
| 2 | MP0003635_abnormal_synaptic_transmissio | 3.66996995 |
| 3 | MP0004270_analgesia | 3.17583885 |
| 4 | MP0003880_abnormal_central_pattern | 2.88543315 |
| 5 | MP0002063_abnormal_learning/memory/cond | 2.78990110 |
| 6 | MP0004858_abnormal_nervous_system | 2.73736693 |
| 7 | MP0009046_muscle_twitch | 2.70887245 |
| 8 | MP0009745_abnormal_behavioral_response | 2.67974965 |
| 9 | MP0009780_abnormal_chondrocyte_physiolo | 2.64719406 |
| 10 | MP0005423_abnormal_somatic_nervous | 2.62881679 |
| 11 | MP0002064_seizures | 2.60710746 |
| 12 | MP0002734_abnormal_mechanical_nocicepti | 2.21119805 |
| 13 | MP0008569_lethality_at_weaning | 2.20015250 |
| 14 | MP0002572_abnormal_emotion/affect_behav | 2.19577734 |
| 15 | MP0001486_abnormal_startle_reflex | 2.14069361 |
| 16 | MP0001968_abnormal_touch/_nociception | 2.13647241 |
| 17 | MP0004885_abnormal_endolymph | 2.08449206 |
| 18 | MP0000778_abnormal_nervous_system | 2.07244753 |
| 19 | MP0002272_abnormal_nervous_system | 2.00620825 |
| 20 | MP0008438_abnormal_cutaneous_collagen | 1.88733276 |
| 21 | MP0002909_abnormal_adrenal_gland | 1.88078430 |
| 22 | MP0005409_darkened_coat_color | 1.86553148 |
| 23 | MP0000751_myopathy | 1.80336035 |
| 24 | MP0002249_abnormal_larynx_morphology | 1.79716570 |
| 25 | MP0005623_abnormal_meninges_morphology | 1.78881576 |
| 26 | MP0003283_abnormal_digestive_organ | 1.78235578 |
| 27 | MP0002184_abnormal_innervation | 1.76238533 |
| 28 | MP0002067_abnormal_sensory_capabilities | 1.74783379 |
| 29 | MP0003329_amyloid_beta_deposits | 1.73093240 |
| 30 | MP0000955_abnormal_spinal_cord | 1.70508243 |
| 31 | MP0002733_abnormal_thermal_nociception | 1.68737457 |
| 32 | MP0004145_abnormal_muscle_electrophysio | 1.66554686 |
| 33 | MP0004811_abnormal_neuron_physiology | 1.65902201 |
| 34 | MP0001440_abnormal_grooming_behavior | 1.65083444 |
| 35 | MP0001958_emphysema | 1.57989217 |
| 36 | MP0001501_abnormal_sleep_pattern | 1.57795853 |
| 37 | MP0002557_abnormal_social/conspecific_i | 1.57093782 |
| 38 | MP0000566_synostosis | 1.53359048 |
| 39 | MP0001970_abnormal_pain_threshold | 1.51386753 |
| 40 | MP0002736_abnormal_nociception_after | 1.51365737 |
| 41 | MP0003123_paternal_imprinting | 1.48085918 |
| 42 | MP0001348_abnormal_lacrimal_gland | 1.41313713 |
| 43 | MP0000579_abnormal_nail_morphology | 1.40276044 |
| 44 | MP0002735_abnormal_chemical_nociception | 1.37870356 |
| 45 | MP0002882_abnormal_neuron_morphology | 1.37800300 |
| 46 | MP0004233_abnormal_muscle_weight | 1.37015266 |
| 47 | MP0001299_abnormal_eye_distance/ | 1.34884723 |
| 48 | MP0005386_behavior/neurological_phenoty | 1.29338347 |
| 49 | MP0004924_abnormal_behavior | 1.29338347 |
| 50 | MP0002066_abnormal_motor_capabilities/c | 1.28527700 |
| 51 | MP0002152_abnormal_brain_morphology | 1.26121675 |
| 52 | MP0003122_maternal_imprinting | 1.22335693 |
| 53 | MP0003633_abnormal_nervous_system | 1.21952233 |
| 54 | MP0008961_abnormal_basal_metabolism | 1.21176184 |
| 55 | MP0003879_abnormal_hair_cell | 1.19561511 |
| 56 | MP0003634_abnormal_glial_cell | 1.17681327 |
| 57 | MP0003172_abnormal_lysosome_physiology | 1.17426531 |
| 58 | MP0001984_abnormal_olfaction | 1.15538823 |
| 59 | MP0004215_abnormal_myocardial_fiber | 1.14980735 |
| 60 | MP0003279_aneurysm | 1.12885906 |
| 61 | MP0001502_abnormal_circadian_rhythm | 1.12878513 |
| 62 | MP0005646_abnormal_pituitary_gland | 1.11983032 |
| 63 | MP0005503_abnormal_tendon_morphology | 1.10622184 |
| 64 | MP0003787_abnormal_imprinting | 1.09838512 |
| 65 | MP0005257_abnormal_intraocular_pressure | 1.09652467 |
| 66 | MP0002822_catalepsy | 1.08444857 |
| 67 | MP0000013_abnormal_adipose_tissue | 1.08401803 |
| 68 | MP0002089_abnormal_postnatal_growth/wei | 1.07562230 |
| 69 | MP0000569_abnormal_digit_pigmentation | 1.05429872 |
| 70 | MP0000604_amyloidosis | 1.05154263 |
| 71 | MP0003690_abnormal_glial_cell | 1.05149143 |
| 72 | MP0001849_ear_inflammation | 1.04873109 |
| 73 | MP0005187_abnormal_penis_morphology | 1.03921122 |
| 74 | MP0003631_nervous_system_phenotype | 1.03482325 |
| 75 | MP0002653_abnormal_ependyma_morphology | 1.02090121 |
| 76 | MP0003137_abnormal_impulse_conducting | 0.99583136 |
| 77 | MP0004130_abnormal_muscle_cell | 0.99163509 |
| 78 | MP0002837_dystrophic_cardiac_calcinosis | 0.98805312 |
| 79 | MP0000534_abnormal_ureter_morphology | 0.98297109 |
| 80 | MP0005167_abnormal_blood-brain_barrier | 0.97793153 |
| 81 | MP0004142_abnormal_muscle_tone | 0.97231488 |
| 82 | MP0003632_abnormal_nervous_system | 0.95676690 |
| 83 | MP0001177_atelectasis | 0.91518199 |
| 84 | MP0005076_abnormal_cell_differentiation | 0.91168475 |
| 85 | MP0004085_abnormal_heartbeat | 0.89249567 |
| 86 | MP0003566_abnormal_cell_adhesion | 0.89247598 |
| 87 | MP0005645_abnormal_hypothalamus_physiol | 0.89127425 |
| 88 | MP0003861_abnormal_nervous_system | 0.87021224 |
| 89 | MP0002234_abnormal_pharynx_morphology | 0.86948605 |
| 90 | MP0000462_abnormal_digestive_system | 0.86109835 |
| 91 | MP0000631_abnormal_neuroendocrine_gland | 0.85355934 |
| 92 | MP0004272_abnormal_basement_membrane | 0.85272468 |
| 93 | MP0000003_abnormal_adipose_tissue | 0.84107474 |
| 94 | MP0002896_abnormal_bone_mineralization | 0.81518814 |
| 95 | MP0000747_muscle_weakness | 0.81080551 |
| 96 | MP0005171_absent_coat_pigmentation | 0.80777453 |
| 97 | MP0001346_abnormal_lacrimal_gland | 0.80288391 |
| 98 | MP0003115_abnormal_respiratory_system | 0.78231324 |
| 99 | MP0003705_abnormal_hypodermis_morpholog | 0.78216262 |
| 100 | MP0003646_muscle_fatigue | 0.78099600 |
| 101 | MP0002069_abnormal_eating/drinking_beha | 0.78068858 |
| 102 | MP0003091_abnormal_cell_migration | 0.77627879 |
| 103 | MP0000762_abnormal_tongue_morphology | 0.77459326 |
| 104 | MP0004087_abnormal_muscle_fiber | 0.77149646 |
| 105 | MP0001485_abnormal_pinna_reflex | 0.77104560 |
| 106 | MP0000678_abnormal_parathyroid_gland | 0.76751689 |
| 107 | MP0005394_taste/olfaction_phenotype | 0.76168181 |
| 108 | MP0005499_abnormal_olfactory_system | 0.76168181 |
| 109 | MP0002090_abnormal_vision | 0.75756742 |
| 110 | MP0000920_abnormal_myelination | 0.75639464 |
| 111 | MP0006072_abnormal_retinal_apoptosis | 0.72247872 |
| 112 | MP0001963_abnormal_hearing_physiology | 0.72172383 |
| 113 | MP0004484_altered_response_of | 0.71486409 |
| 114 | MP0005058_abnormal_lysosome_morphology | 0.70701229 |
| 115 | MP0004084_abnormal_cardiac_muscle | 0.70162122 |
| 116 | MP0000733_abnormal_muscle_development | 0.69933881 |
| 117 | MP0002229_neurodegeneration | 0.69370615 |
| 118 | MP0002752_abnormal_somatic_nervous | 0.68112896 |
| 119 | MP0001943_abnormal_respiration | 0.67933913 |
| 120 | MP0009384_cardiac_valve_regurgitation | 0.67453500 |
| 121 | MP0003942_abnormal_urinary_system | 0.67171867 |
| 122 | MP0005508_abnormal_skeleton_morphology | 0.65119592 |
| 123 | MP0005620_abnormal_muscle_contractility | 0.64838730 |
| 124 | MP0000759_abnormal_skeletal_muscle | 0.64835424 |
| 125 | MP0005551_abnormal_eye_electrophysiolog | 0.64466107 |
| 126 | MP0003385_abnormal_body_wall | 0.64334304 |
| 127 | MP0005670_abnormal_white_adipose | 0.64184329 |
| 128 | MP0003075_altered_response_to | 0.63985190 |
| 129 | MP0003045_fibrosis | 0.63801287 |
| 130 | MP0006276_abnormal_autonomic_nervous | 0.63421993 |
| 131 | MP0010769_abnormal_survival | 0.63235035 |
| 132 | MP0002108_abnormal_muscle_morphology | 0.63167966 |
| 133 | MP0000749_muscle_degeneration | 0.62150611 |
| 134 | MP0000681_abnormal_thyroid_gland | 0.62141363 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 4.55998132 |
| 2 | Focal motor seizures (HP:0011153) | 4.23804321 |
| 3 | Visual hallucinations (HP:0002367) | 4.15462486 |
| 4 | Action tremor (HP:0002345) | 4.01933662 |
| 5 | Focal seizures (HP:0007359) | 3.84507590 |
| 6 | Progressive cerebellar ataxia (HP:0002073) | 3.84427267 |
| 7 | Protrusio acetabuli (HP:0003179) | 3.49508734 |
| 8 | Megalencephaly (HP:0001355) | 3.29024142 |
| 9 | Genetic anticipation (HP:0003743) | 3.28439043 |
| 10 | Epileptic encephalopathy (HP:0200134) | 3.11973390 |
| 11 | Supranuclear gaze palsy (HP:0000605) | 3.06075213 |
| 12 | Dysdiadochokinesis (HP:0002075) | 2.86258985 |
| 13 | Hemiplegia (HP:0002301) | 2.83620112 |
| 14 | Ankle clonus (HP:0011448) | 2.79228171 |
| 15 | Depression (HP:0000716) | 2.76820489 |
| 16 | Cerebral aneurysm (HP:0004944) | 2.74578336 |
| 17 | Shallow orbits (HP:0000586) | 2.68257819 |
| 18 | Insomnia (HP:0100785) | 2.65880315 |
| 19 | Atonic seizures (HP:0010819) | 2.65447289 |
| 20 | Absence seizures (HP:0002121) | 2.63664788 |
| 21 | Peripheral hypomyelination (HP:0007182) | 2.60784314 |
| 22 | Premature rupture of membranes (HP:0001788) | 2.59949725 |
| 23 | Abnormality of the lower motor neuron (HP:0002366) | 2.59848292 |
| 24 | Poor eye contact (HP:0000817) | 2.59237348 |
| 25 | Hemiparesis (HP:0001269) | 2.55743487 |
| 26 | Generalized tonic-clonic seizures (HP:0002069) | 2.53998431 |
| 27 | Ventricular fibrillation (HP:0001663) | 2.52933764 |
| 28 | Broad-based gait (HP:0002136) | 2.52728357 |
| 29 | Dysmetric saccades (HP:0000641) | 2.50388179 |
| 30 | Impaired social interactions (HP:0000735) | 2.49623399 |
| 31 | Abnormal social behavior (HP:0012433) | 2.49623399 |
| 32 | Papilledema (HP:0001085) | 2.44979234 |
| 33 | Akinesia (HP:0002304) | 2.44965356 |
| 34 | Obstructive sleep apnea (HP:0002870) | 2.42811061 |
| 35 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.40768019 |
| 36 | Gaze-evoked nystagmus (HP:0000640) | 2.39767246 |
| 37 | Upper limb amyotrophy (HP:0009129) | 2.37606684 |
| 38 | Distal upper limb amyotrophy (HP:0007149) | 2.37606684 |
| 39 | Postural instability (HP:0002172) | 2.37218619 |
| 40 | Mutism (HP:0002300) | 2.36250965 |
| 41 | Deep venous thrombosis (HP:0002625) | 2.36211770 |
| 42 | Febrile seizures (HP:0002373) | 2.35334947 |
| 43 | Pointed chin (HP:0000307) | 2.34664247 |
| 44 | Intention tremor (HP:0002080) | 2.34448413 |
| 45 | Hyperacusis (HP:0010780) | 2.33893967 |
| 46 | Ulnar bowing (HP:0003031) | 2.32989357 |
| 47 | Neonatal short-limb short stature (HP:0008921) | 2.32435305 |
| 48 | Bundle branch block (HP:0011710) | 2.32396600 |
| 49 | Truncal ataxia (HP:0002078) | 2.31836293 |
| 50 | Abnormal eating behavior (HP:0100738) | 2.31543028 |
| 51 | Mitral regurgitation (HP:0001653) | 2.27979470 |
| 52 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.26235884 |
| 53 | Aplasia involving bones of the extremities (HP:0009825) | 2.24218681 |
| 54 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.24218681 |
| 55 | Aplasia of the phalanges of the hand (HP:0009802) | 2.24218681 |
| 56 | Anxiety (HP:0000739) | 2.24210075 |
| 57 | Dialeptic seizures (HP:0011146) | 2.21253702 |
| 58 | Bladder diverticulum (HP:0000015) | 2.20360577 |
| 59 | Abnormality of binocular vision (HP:0011514) | 2.20237838 |
| 60 | Diplopia (HP:0000651) | 2.20237838 |
| 61 | Dysmetria (HP:0001310) | 2.18873481 |
| 62 | Vascular tortuosity (HP:0004948) | 2.17205753 |
| 63 | Broad metatarsal (HP:0001783) | 2.16585480 |
| 64 | Impaired smooth pursuit (HP:0007772) | 2.13945406 |
| 65 | Elfin facies (HP:0004428) | 2.13271364 |
| 66 | Arterial tortuosity (HP:0005116) | 2.12028492 |
| 67 | Bowel diverticulosis (HP:0005222) | 2.09393652 |
| 68 | Cerebral inclusion bodies (HP:0100314) | 2.09372898 |
| 69 | Neoplasm of the heart (HP:0100544) | 2.08791741 |
| 70 | Excessive salivation (HP:0003781) | 2.08371194 |
| 71 | Drooling (HP:0002307) | 2.08371194 |
| 72 | Sleep apnea (HP:0010535) | 2.06750811 |
| 73 | Macroorchidism (HP:0000053) | 2.06419936 |
| 74 | Urinary urgency (HP:0000012) | 2.02966927 |
| 75 | Torticollis (HP:0000473) | 2.02467206 |
| 76 | Neurofibrillary tangles (HP:0002185) | 2.01997234 |
| 77 | Annular pancreas (HP:0001734) | 2.00883599 |
| 78 | Agitation (HP:0000713) | 1.98539099 |
| 79 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.98484322 |
| 80 | Overriding aorta (HP:0002623) | 1.94201126 |
| 81 | Hand muscle atrophy (HP:0009130) | 1.94008520 |
| 82 | Foot dorsiflexor weakness (HP:0009027) | 1.90784607 |
| 83 | Increased variability in muscle fiber diameter (HP:0003557) | 1.90515212 |
| 84 | Termporal pattern (HP:0011008) | 1.90155053 |
| 85 | Insidious onset (HP:0003587) | 1.90155053 |
| 86 | Myotonia (HP:0002486) | 1.90153449 |
| 87 | Bronchomalacia (HP:0002780) | 1.89570283 |
| 88 | Broad face (HP:0000283) | 1.88829186 |
| 89 | Hammertoe (HP:0001765) | 1.88467913 |
| 90 | Turricephaly (HP:0000262) | 1.88142317 |
| 91 | Exercise-induced myalgia (HP:0003738) | 1.88081107 |
| 92 | Stereotypic behavior (HP:0000733) | 1.86759547 |
| 93 | Thin ribs (HP:0000883) | 1.86515736 |
| 94 | Difficulty running (HP:0009046) | 1.86134703 |
| 95 | Mild short stature (HP:0003502) | 1.85445097 |
| 96 | Enlarged penis (HP:0000040) | 1.85156779 |
| 97 | Type 1 muscle fiber predominance (HP:0003803) | 1.83187398 |
| 98 | Hyporeflexia of lower limbs (HP:0002600) | 1.83121435 |
| 99 | Postural tremor (HP:0002174) | 1.83002887 |
| 100 | Atrophic scars (HP:0001075) | 1.81861373 |
| 101 | Overgrowth (HP:0001548) | 1.81360473 |
| 102 | Amyotrophic lateral sclerosis (HP:0007354) | 1.80686959 |
| 103 | Fragile skin (HP:0001030) | 1.80439299 |
| 104 | Hyperparathyroidism (HP:0000843) | 1.80286006 |
| 105 | Lower limb muscle weakness (HP:0007340) | 1.80182096 |
| 106 | Renal duplication (HP:0000075) | 1.79814819 |
| 107 | Arnold-Chiari malformation (HP:0002308) | 1.79781159 |
| 108 | Fetal akinesia sequence (HP:0001989) | 1.78457292 |
| 109 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.77791951 |
| 110 | Scanning speech (HP:0002168) | 1.77627722 |
| 111 | Craniofacial dystonia (HP:0012179) | 1.77550314 |
| 112 | Stridor (HP:0010307) | 1.76492093 |
| 113 | Tetraplegia (HP:0002445) | 1.76261744 |
| 114 | Spastic gait (HP:0002064) | 1.76246313 |
| 115 | Biconcave vertebral bodies (HP:0004586) | 1.75631949 |
| 116 | Aqueductal stenosis (HP:0002410) | 1.75442462 |
| 117 | Hypoventilation (HP:0002791) | 1.74792063 |
| 118 | Amblyopia (HP:0000646) | 1.74639714 |
| 119 | Abnormality of the corticospinal tract (HP:0002492) | 1.74487785 |
| 120 | Focal dystonia (HP:0004373) | 1.74356415 |
| 121 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 1.73849790 |
| 122 | Spinal rigidity (HP:0003306) | 1.73684629 |
| 123 | Renovascular hypertension (HP:0100817) | 1.73049908 |
| 124 | Prolonged QT interval (HP:0001657) | 1.71856524 |
| 125 | Pheochromocytoma (HP:0002666) | 1.71833352 |
| 126 | Neuronal loss in central nervous system (HP:0002529) | 1.71833032 |
| 127 | Sudden death (HP:0001699) | 1.71816076 |
| 128 | Wormian bones (HP:0002645) | 1.71783014 |
| 129 | Lower limb amyotrophy (HP:0007210) | 1.71555591 |
| 130 | Hypercortisolism (HP:0001578) | 1.71122506 |
| 131 | Hyperextensible skin (HP:0000974) | 1.71062304 |
| 132 | Abnormality of the foot musculature (HP:0001436) | 1.69987658 |
| 133 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.69681823 |
| 134 | Bradykinesia (HP:0002067) | 1.69661641 |
| 135 | Lower limb asymmetry (HP:0100559) | 1.69431432 |
| 136 | EEG with generalized epileptiform discharges (HP:0011198) | 1.67531612 |
| 137 | Bowel incontinence (HP:0002607) | 1.67409781 |
| 138 | Alacrima (HP:0000522) | 1.67295236 |
| 139 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.66540957 |
| 140 | Rapidly progressive (HP:0003678) | 1.65538704 |
| 141 | Flat cornea (HP:0007720) | 1.65427052 |
| 142 | Truncus arteriosus (HP:0001660) | 1.65423586 |
| 143 | Spinal canal stenosis (HP:0003416) | 1.64649135 |
| 144 | Achilles tendon contracture (HP:0001771) | 1.64360230 |
| 145 | Round ear (HP:0100830) | 1.63835958 |
| 146 | Vertebral arch anomaly (HP:0008438) | 1.63613574 |
| 147 | Rigidity (HP:0002063) | 1.61953989 |
| 148 | Abnormality of dentin (HP:0010299) | 1.61400116 |
| 149 | Coronal craniosynostosis (HP:0004440) | 1.61070887 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 3.67612254 |
| 2 | MAP3K9 | 3.25038607 |
| 3 | NTRK3 | 3.21223143 |
| 4 | NTRK2 | 2.65458558 |
| 5 | PAK6 | 2.61554951 |
| 6 | PRKD3 | 2.50641889 |
| 7 | MAP3K4 | 2.33649482 |
| 8 | MINK1 | 2.32166208 |
| 9 | TRIB3 | 2.31665941 |
| 10 | EPHA4 | 2.22122751 |
| 11 | PHKG1 | 2.17332214 |
| 12 | PHKG2 | 2.17332214 |
| 13 | CAMKK1 | 2.12691738 |
| 14 | RIPK1 | 2.00318918 |
| 15 | DAPK2 | 1.90205488 |
| 16 | NTRK1 | 1.89377895 |
| 17 | LMTK2 | 1.85676477 |
| 18 | TYRO3 | 1.77406902 |
| 19 | KSR2 | 1.72937860 |
| 20 | EEF2K | 1.66823093 |
| 21 | LATS2 | 1.66093828 |
| 22 | FGFR4 | 1.64906084 |
| 23 | STK38 | 1.59218146 |
| 24 | MAP2K7 | 1.42161717 |
| 25 | MAP2K4 | 1.40772633 |
| 26 | KSR1 | 1.39088488 |
| 27 | CDK5 | 1.36937128 |
| 28 | PDGFRA | 1.32726316 |
| 29 | CDK12 | 1.28541810 |
| 30 | SMG1 | 1.25635614 |
| 31 | DDR2 | 1.24311637 |
| 32 | ARAF | 1.20771461 |
| 33 | RET | 1.19878619 |
| 34 | SIK2 | 1.18769513 |
| 35 | UHMK1 | 1.18540858 |
| 36 | ALK | 1.17032111 |
| 37 | TAOK1 | 1.16210256 |
| 38 | CAMK1G | 1.15872739 |
| 39 | CAMKK2 | 1.14287653 |
| 40 | PRKCH | 1.13285630 |
| 41 | DMPK | 1.10897418 |
| 42 | NEK6 | 1.08728851 |
| 43 | PAK3 | 1.07739262 |
| 44 | MAPK13 | 1.04195307 |
| 45 | PLK2 | 1.00434683 |
| 46 | STK11 | 0.99342095 |
| 47 | TESK1 | 0.99242855 |
| 48 | PKN2 | 0.99196119 |
| 49 | ICK | 0.99136479 |
| 50 | PRKCG | 0.96041666 |
| 51 | SIK1 | 0.95291838 |
| 52 | CDK15 | 0.94671442 |
| 53 | MAP3K2 | 0.93266945 |
| 54 | CDK14 | 0.91893941 |
| 55 | SGK3 | 0.91871274 |
| 56 | CDK18 | 0.91415113 |
| 57 | TNIK | 0.87508938 |
| 58 | PRPF4B | 0.86422655 |
| 59 | PNCK | 0.86360986 |
| 60 | CDC42BPA | 0.86255087 |
| 61 | SGK494 | 0.83001259 |
| 62 | SGK223 | 0.83001259 |
| 63 | TTN | 0.82815315 |
| 64 | MAPK12 | 0.82480941 |
| 65 | CDK11A | 0.82419920 |
| 66 | NEK1 | 0.81883934 |
| 67 | GRK5 | 0.81570106 |
| 68 | WNK1 | 0.80095328 |
| 69 | MTOR | 0.80041551 |
| 70 | MARK2 | 0.79855424 |
| 71 | CAMK1 | 0.77649522 |
| 72 | SGK2 | 0.75470605 |
| 73 | FGFR3 | 0.74995665 |
| 74 | FGFR2 | 0.73611194 |
| 75 | BMX | 0.72917667 |
| 76 | PKN1 | 0.70463836 |
| 77 | BRSK1 | 0.70292643 |
| 78 | FER | 0.69546526 |
| 79 | MAPK15 | 0.68678265 |
| 80 | ROCK2 | 0.68287212 |
| 81 | CAMK2A | 0.67344838 |
| 82 | DYRK1A | 0.66158280 |
| 83 | ROCK1 | 0.65484958 |
| 84 | PINK1 | 0.64537353 |
| 85 | CASK | 0.64156527 |
| 86 | DAPK1 | 0.64108380 |
| 87 | MAP3K13 | 0.64014940 |
| 88 | PAK2 | 0.63824604 |
| 89 | SCYL2 | 0.62582841 |
| 90 | ERN1 | 0.61067644 |
| 91 | CDK19 | 0.60387195 |
| 92 | LIMK1 | 0.59551643 |
| 93 | MAP3K7 | 0.59049035 |
| 94 | SGK1 | 0.58975572 |
| 95 | CSNK1G2 | 0.58649630 |
| 96 | PRKD2 | 0.57773207 |
| 97 | PTK6 | 0.57336295 |
| 98 | RPS6KA3 | 0.55870090 |
| 99 | TNK2 | 0.55629411 |
| 100 | PTK2 | 0.54229197 |
| 101 | ERBB2 | 0.54132057 |
| 102 | CAMK4 | 0.52045815 |
| 103 | PRKCZ | 0.52012596 |
| 104 | EPHB2 | 0.50530467 |
| 105 | MOS | 0.49633962 |
| 106 | EPHA2 | 0.48033540 |
| 107 | PDGFRB | 0.47778826 |
| 108 | FES | 0.47660236 |
| 109 | MAPK10 | 0.47065510 |
| 110 | FYN | 0.46331815 |
| 111 | PRKD1 | 0.46149241 |
| 112 | RPS6KA2 | 0.45733872 |
| 113 | MAP2K1 | 0.45335920 |
| 114 | FGFR1 | 0.44825959 |
| 115 | CAMK1D | 0.44102209 |
| 116 | MAP3K1 | 0.43952679 |
| 117 | MET | 0.43702957 |
| 118 | BRAF | 0.42480953 |
| 119 | ERBB3 | 0.41776541 |
| 120 | PDPK1 | 0.41585714 |
| 121 | CAMK2B | 0.40801442 |
| 122 | CAMK2D | 0.40033794 |
| 123 | PRKAA1 | 0.39648983 |
| 124 | DYRK1B | 0.39110274 |
| 125 | MAPKAPK3 | 0.38875097 |
| 126 | PDK1 | 0.38775677 |
| 127 | MAPK8 | 0.38304704 |
| 128 | CAMK2G | 0.38145014 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 2.70358866 |
| 2 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.48966743 |
| 3 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.46532622 |
| 4 | GABAergic synapse_Homo sapiens_hsa04727 | 2.32007855 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.28934964 |
| 6 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.26493901 |
| 7 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.24951236 |
| 8 | Long-term potentiation_Homo sapiens_hsa04720 | 2.12274130 |
| 9 | Olfactory transduction_Homo sapiens_hsa04740 | 2.06951227 |
| 10 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.03000668 |
| 11 | Morphine addiction_Homo sapiens_hsa05032 | 1.91757287 |
| 12 | Insulin secretion_Homo sapiens_hsa04911 | 1.86228295 |
| 13 | Salivary secretion_Homo sapiens_hsa04970 | 1.85316176 |
| 14 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.83876090 |
| 15 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.81341135 |
| 16 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.75977106 |
| 17 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.73211148 |
| 18 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.67442810 |
| 19 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.67376212 |
| 20 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.63283480 |
| 21 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.58337308 |
| 22 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.58287780 |
| 23 | Long-term depression_Homo sapiens_hsa04730 | 1.50915859 |
| 24 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.49455272 |
| 25 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.48386125 |
| 26 | Renin secretion_Homo sapiens_hsa04924 | 1.39264180 |
| 27 | Gap junction_Homo sapiens_hsa04540 | 1.38966588 |
| 28 | Cocaine addiction_Homo sapiens_hsa05030 | 1.38665919 |
| 29 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.37834695 |
| 30 | Taste transduction_Homo sapiens_hsa04742 | 1.36318526 |
| 31 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.34303433 |
| 32 | Glioma_Homo sapiens_hsa05214 | 1.33561213 |
| 33 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.31952253 |
| 34 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.29747058 |
| 35 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.24915247 |
| 36 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.24779342 |
| 37 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.22433328 |
| 38 | Axon guidance_Homo sapiens_hsa04360 | 1.22414435 |
| 39 | Melanogenesis_Homo sapiens_hsa04916 | 1.18245382 |
| 40 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.13156639 |
| 41 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.09832032 |
| 42 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.08604842 |
| 43 | ECM-receptor interaction_Homo sapiens_hsa04512 | 1.07295488 |
| 44 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.03898325 |
| 45 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.03722875 |
| 46 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.01234373 |
| 47 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.00179049 |
| 48 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.98914405 |
| 49 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.98644299 |
| 50 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.95218831 |
| 51 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.94565069 |
| 52 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.94206645 |
| 53 | Endometrial cancer_Homo sapiens_hsa05213 | 0.92797450 |
| 54 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.90871114 |
| 55 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.90271900 |
| 56 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.88737369 |
| 57 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.88434784 |
| 58 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.87022574 |
| 59 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.84999195 |
| 60 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.84132321 |
| 61 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.83106990 |
| 62 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.82601591 |
| 63 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.82498620 |
| 64 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.80198731 |
| 65 | Histidine metabolism_Homo sapiens_hsa00340 | 0.78731587 |
| 66 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.77817986 |
| 67 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.77058611 |
| 68 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.76427401 |
| 69 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.75509413 |
| 70 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.75493211 |
| 71 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.75324384 |
| 72 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.73910102 |
| 73 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.73421239 |
| 74 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.73324306 |
| 75 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.72769972 |
| 76 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.72418612 |
| 77 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.71945915 |
| 78 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.71633950 |
| 79 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.70825752 |
| 80 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.70726747 |
| 81 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.69772135 |
| 82 | Bile secretion_Homo sapiens_hsa04976 | 0.69625176 |
| 83 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.68283071 |
| 84 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.67338401 |
| 85 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.67162775 |
| 86 | Adherens junction_Homo sapiens_hsa04520 | 0.65849673 |
| 87 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.64886688 |
| 88 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.64585383 |
| 89 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.63174742 |
| 90 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.62729809 |
| 91 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.62172033 |
| 92 | Focal adhesion_Homo sapiens_hsa04510 | 0.61854730 |
| 93 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.61546416 |
| 94 | Colorectal cancer_Homo sapiens_hsa05210 | 0.61200790 |
| 95 | Amoebiasis_Homo sapiens_hsa05146 | 0.60800888 |
| 96 | Circadian rhythm_Homo sapiens_hsa04710 | 0.57999728 |
| 97 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.57897734 |
| 98 | Endocytosis_Homo sapiens_hsa04144 | 0.57536684 |
| 99 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.56796498 |
| 100 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.56684632 |
| 101 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.56599166 |
| 102 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.56394572 |
| 103 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.55231231 |
| 104 | Tight junction_Homo sapiens_hsa04530 | 0.54263490 |
| 105 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.54175133 |
| 106 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.52252456 |
| 107 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.50727286 |
| 108 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.50170506 |
| 109 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.50150903 |
| 110 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.47258196 |
| 111 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.46902618 |
| 112 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.45895126 |
| 113 | Insulin resistance_Homo sapiens_hsa04931 | 0.45104744 |
| 114 | Prion diseases_Homo sapiens_hsa05020 | 0.42966883 |
| 115 | Melanoma_Homo sapiens_hsa05218 | 0.42839838 |
| 116 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.42372710 |
| 117 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.41556779 |
| 118 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.41311602 |
| 119 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.41283842 |

