MTUS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.94779759
2L-phenylalanine catabolic process (GO:0006559)5.94779759
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.60014244
4L-phenylalanine metabolic process (GO:0006558)5.60014244
5aromatic amino acid family catabolic process (GO:0009074)5.12951763
6alpha-linolenic acid metabolic process (GO:0036109)4.92819591
7glyoxylate metabolic process (GO:0046487)4.74472732
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.73368325
9sulfur amino acid catabolic process (GO:0000098)4.62726023
10lysine catabolic process (GO:0006554)4.61995903
11lysine metabolic process (GO:0006553)4.61995903
12kynurenine metabolic process (GO:0070189)4.61693983
13complement activation, alternative pathway (GO:0006957)4.56687899
14bile acid biosynthetic process (GO:0006699)4.53274403
15urea metabolic process (GO:0019627)4.47425523
16urea cycle (GO:0000050)4.47425523
17tryptophan catabolic process (GO:0006569)4.47083590
18indole-containing compound catabolic process (GO:0042436)4.47083590
19indolalkylamine catabolic process (GO:0046218)4.47083590
20cysteine metabolic process (GO:0006534)4.46507456
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.45186646
22regulation of protein activation cascade (GO:2000257)4.39822403
23peptidyl-glutamic acid carboxylation (GO:0017187)4.32217436
24protein carboxylation (GO:0018214)4.32217436
25tryptophan metabolic process (GO:0006568)4.22219590
26regulation of triglyceride catabolic process (GO:0010896)4.19477772
27regulation of complement activation (GO:0030449)4.16919887
28nitrogen cycle metabolic process (GO:0071941)4.09990399
29negative regulation of fibrinolysis (GO:0051918)4.09861178
30cellular ketone body metabolic process (GO:0046950)4.07704323
31amino-acid betaine metabolic process (GO:0006577)4.04494731
32high-density lipoprotein particle remodeling (GO:0034375)3.98531370
33bile acid metabolic process (GO:0008206)3.97741831
34homocysteine metabolic process (GO:0050667)3.93418419
35cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.90306483
36serine family amino acid catabolic process (GO:0009071)3.88991753
37regulation of fibrinolysis (GO:0051917)3.82325712
38bile acid and bile salt transport (GO:0015721)3.78637373
39acylglycerol homeostasis (GO:0055090)3.78206322
40triglyceride homeostasis (GO:0070328)3.78206322
41fatty acid transmembrane transport (GO:1902001)3.74881422
42fatty acid beta-oxidation (GO:0006635)3.74021105
43alpha-amino acid catabolic process (GO:1901606)3.73123203
44regulation of actin filament-based movement (GO:1903115)3.71974094
45acetyl-CoA metabolic process (GO:0006084)3.71822344
46ethanol oxidation (GO:0006069)3.71739284
47coenzyme catabolic process (GO:0009109)3.67687951
48aspartate family amino acid catabolic process (GO:0009068)3.65938110
49fatty acid oxidation (GO:0019395)3.64606366
50short-chain fatty acid metabolic process (GO:0046459)3.64049865
51drug catabolic process (GO:0042737)3.63159169
52aromatic amino acid family metabolic process (GO:0009072)3.60700860
53lipid oxidation (GO:0034440)3.58012999
54reverse cholesterol transport (GO:0043691)3.57887468
55plasma lipoprotein particle remodeling (GO:0034369)3.57364716
56protein-lipid complex remodeling (GO:0034368)3.57364716
57macromolecular complex remodeling (GO:0034367)3.57364716
58regulation of bile acid biosynthetic process (GO:0070857)3.53895753
59plasma lipoprotein particle clearance (GO:0034381)3.53648423
60cellular amino acid catabolic process (GO:0009063)3.53360821
61carnitine shuttle (GO:0006853)3.52886442
62positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.51712354
632-oxoglutarate metabolic process (GO:0006103)3.51680025
64phospholipid homeostasis (GO:0055091)3.50186049
65fatty acid catabolic process (GO:0009062)3.49870216
66tyrosine metabolic process (GO:0006570)3.49541875
67cell communication involved in cardiac conduction (GO:0086065)3.49444899
68ketone body metabolic process (GO:1902224)3.47028475
69cellular modified amino acid catabolic process (GO:0042219)3.45276734
70positive regulation of fatty acid beta-oxidation (GO:0032000)3.43463678
71regulation of cell communication by electrical coupling (GO:0010649)3.40848854
72phospholipid efflux (GO:0033700)3.39847060
73monocarboxylic acid catabolic process (GO:0072329)3.38053413
74cellular sodium ion homeostasis (GO:0006883)3.35274872
75bundle of His cell to Purkinje myocyte communication (GO:0086069)3.33888910
76biotin metabolic process (GO:0006768)3.33125996
77regulation of sequestering of triglyceride (GO:0010889)3.31121707
78cellular glucuronidation (GO:0052695)3.29399197
79regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.29019228
80regulation of cholesterol esterification (GO:0010872)3.28964839
81positive regulation of lipid catabolic process (GO:0050996)3.28020529
82glutamate metabolic process (GO:0006536)3.27770039
83cholesterol efflux (GO:0033344)3.27424062
84organic acid catabolic process (GO:0016054)3.27264831
85carboxylic acid catabolic process (GO:0046395)3.27264831
86negative regulation of lipase activity (GO:0060192)3.24495551
87regulation of cardiac muscle cell contraction (GO:0086004)3.23866358
88sodium ion export (GO:0071436)3.21985977
89benzene-containing compound metabolic process (GO:0042537)3.19350248
90cholesterol homeostasis (GO:0042632)3.19334490
91carnitine metabolic process (GO:0009437)3.19261196
92regulation of relaxation of muscle (GO:1901077)3.17728124
93negative regulation of protein activation cascade (GO:2000258)3.17303542
94regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.16941687
95sterol homeostasis (GO:0055092)3.16872059
96disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.14916490
97killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.14916490
98arginine metabolic process (GO:0006525)3.13833121
99cell communication by electrical coupling (GO:0010644)3.12413805
100regulation of cholesterol metabolic process (GO:0090181)3.11627705
101regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.11506760
102negative regulation of cholesterol transport (GO:0032375)3.11233283
103negative regulation of sterol transport (GO:0032372)3.11233283
104cellular potassium ion homeostasis (GO:0030007)3.10694299
105fibrinolysis (GO:0042730)3.10413330
106regulation of cholesterol homeostasis (GO:2000188)3.10075673
107positive regulation of fatty acid oxidation (GO:0046321)3.09654414
108valine metabolic process (GO:0006573)3.08923436
109regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.08204825
110response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.07419512
111indolalkylamine metabolic process (GO:0006586)3.07205668
112positive regulation of lipoprotein lipase activity (GO:0051006)3.06568669
113positive regulation of triglyceride lipase activity (GO:0061365)3.06568669
114muscle filament sliding (GO:0030049)3.05905302
115actin-myosin filament sliding (GO:0033275)3.05905302
116branched-chain amino acid catabolic process (GO:0009083)3.04840470
117complement activation (GO:0006956)3.04557911
118sarcoplasmic reticulum calcium ion transport (GO:0070296)3.03662991
119dicarboxylic acid biosynthetic process (GO:0043650)3.02670055
120complement activation, classical pathway (GO:0006958)3.00697787
121relaxation of cardiac muscle (GO:0055119)2.96836231
122membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.95694883
123cardiac muscle contraction (GO:0060048)2.91379632
124ventricular cardiac muscle cell action potential (GO:0086005)2.90633643
125myofibril assembly (GO:0030239)2.87871886
126sarcomere organization (GO:0045214)2.87582946
127sodium ion homeostasis (GO:0055078)2.79801520
128cardiac muscle hypertrophy (GO:0003300)2.76314113
129cardiac myofibril assembly (GO:0055003)2.75339213
130actin-mediated cell contraction (GO:0070252)2.70776152
131potassium ion import (GO:0010107)2.68012957
132striated muscle contraction (GO:0006941)2.65475412
133striated muscle hypertrophy (GO:0014897)2.62656681
134intestinal cholesterol absorption (GO:0030299)2.61793714
135desmosome organization (GO:0002934)2.61781639
136negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.56269005
137cardiac muscle cell action potential (GO:0086001)2.52357110
138regulation of lipoprotein metabolic process (GO:0050746)2.50086004
139axon ensheathment in central nervous system (GO:0032291)2.48911252
140central nervous system myelination (GO:0022010)2.48911252
141cardiac muscle cell action potential involved in contraction (GO:0086002)2.45335270
142NADH metabolic process (GO:0006734)2.44130267
143regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.43568441
144actomyosin structure organization (GO:0031032)2.43519688
145detection of calcium ion (GO:0005513)2.41020107
146embryonic retina morphogenesis in camera-type eye (GO:0060059)2.40932708
147negative regulation of complement activation (GO:0045916)2.39968395
148polyketide metabolic process (GO:0030638)2.39072164
149doxorubicin metabolic process (GO:0044598)2.39072164
150daunorubicin metabolic process (GO:0044597)2.39072164
151regulation of sodium ion transmembrane transport (GO:1902305)2.37896455
152positive regulation of sodium ion transport (GO:0010765)2.37791059
153glutamate secretion (GO:0014047)2.37100712
154negative regulation of hormone metabolic process (GO:0032351)2.37094273
155positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.36847430
156cardiac conduction (GO:0061337)2.36695829
157regulation of sodium ion transmembrane transporter activity (GO:2000649)2.34408230
158artery smooth muscle contraction (GO:0014824)2.32736830
159actin filament-based movement (GO:0030048)2.32045625
160regulation of striated muscle contraction (GO:0006942)2.31985606
161regulation of the force of heart contraction (GO:0002026)2.31921463
162negative regulation of protein localization to cell surface (GO:2000009)2.30200347
163relaxation of muscle (GO:0090075)2.30185469
164neurotransmitter-gated ion channel clustering (GO:0072578)2.29126835
165cytoskeletal anchoring at plasma membrane (GO:0007016)2.26736596
166potassium ion homeostasis (GO:0055075)2.26574235
167muscle hypertrophy (GO:0014896)2.23139510
168macroautophagy (GO:0016236)2.22386890
169renal absorption (GO:0070293)2.21757117
170intestinal absorption (GO:0050892)2.20908363
171chemical homeostasis within a tissue (GO:0048875)2.20267816
172cardiac muscle hypertrophy in response to stress (GO:0014898)2.19731219
173muscle hypertrophy in response to stress (GO:0003299)2.19731219
174cardiac muscle adaptation (GO:0014887)2.19731219
175surfactant homeostasis (GO:0043129)2.19478709
176tonic smooth muscle contraction (GO:0014820)2.17980791
177negative regulation of potassium ion transmembrane transport (GO:1901380)2.16744294
178synaptic vesicle docking involved in exocytosis (GO:0016081)2.15715417
179negative regulation of cytosolic calcium ion concentration (GO:0051481)2.15432970
180transcytosis (GO:0045056)2.15161689
181vascular smooth muscle contraction (GO:0014829)2.15065244
182positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.15032701
183glomerular filtration (GO:0003094)2.13904257
184regulation of heart rate by cardiac conduction (GO:0086091)2.10540909
185positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.09683992
186aminoglycoside antibiotic metabolic process (GO:0030647)2.09270645
187regulation of heart rate (GO:0002027)2.08715632
188phosphate ion transmembrane transport (GO:0035435)2.08249184
189cGMP-mediated signaling (GO:0019934)2.06337259
190regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.04508872
191regulation of membrane repolarization (GO:0060306)2.03663290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.95592034
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.94476970
3LXR_22158963_ChIP-Seq_LIVER_Mouse5.03362721
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.03183636
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.64628169
6* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.25170248
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.70156423
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.50732029
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.69887017
10EZH2_22144423_ChIP-Seq_EOC_Human2.59885473
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.23198256
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12794685
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.10888113
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.09674600
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.04327302
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99298184
17* FOXA2_19822575_ChIP-Seq_HepG2_Human1.87600104
18CLOCK_20551151_ChIP-Seq_293T_Human1.84607621
19GBX2_23144817_ChIP-Seq_PC3_Human1.77781040
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.77488070
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70626200
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60654212
23DROSHA_22980978_ChIP-Seq_HELA_Human1.55273494
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.52261650
25CDX2_20551321_ChIP-Seq_CACO-2_Human1.49754810
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49240840
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.48298397
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46154179
29* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46024537
30TCF4_18268006_ChIP-ChIP_LS174T_Human1.41316586
31TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.40011623
32* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38383034
33* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37974544
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35954791
35SMAD4_21799915_ChIP-Seq_A2780_Human1.35745026
36SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34429927
37* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34399927
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33885031
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31685918
40* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29915132
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29086236
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.28553136
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26964305
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.24410132
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24162675
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24162675
47TBX20_22080862_ChIP-Seq_HEART_Mouse1.23032217
48TBX20_22328084_ChIP-Seq_HEART_Mouse1.23032217
49GATA1_22025678_ChIP-Seq_K562_Human1.21756015
50* HNF4A_19822575_ChIP-Seq_HepG2_Human1.21409698
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.19215600
52* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18968248
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16724208
54* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13628276
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13436455
56* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13242861
57AR_21572438_ChIP-Seq_LNCaP_Human1.12848752
58GATA4_25053715_ChIP-Seq_YYC3_Human1.11325117
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11321684
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11012120
61* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10162863
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.10093268
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.09489694
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.09460468
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09142128
66* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08768663
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07943623
68* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07365004
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07265819
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06907106
71* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06894434
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06163284
73* STAT3_23295773_ChIP-Seq_U87_Human1.05858204
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05022469
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04614273
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04614273
77* TCF4_23295773_ChIP-Seq_U87_Human1.04456249
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04399261
79TP63_17297297_ChIP-ChIP_HaCaT_Human1.03995469
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.03666130
81TP53_16413492_ChIP-PET_HCT116_Human1.03350654
82* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02516706
83* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01576574
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00857417
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00832894
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99943732
87AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99859935
88FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99280140
89* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99253106
90* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99040710
91HTT_18923047_ChIP-ChIP_STHdh_Human0.98832993
92EED_16625203_ChIP-ChIP_MESCs_Mouse0.98566772
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98398952
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97706283
95RARB_27405468_Chip-Seq_BRAIN_Mouse0.96618688
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96059254
97EZH2_27304074_Chip-Seq_ESCs_Mouse0.95901495
98JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95664639
99AR_25329375_ChIP-Seq_VCAP_Human0.95297627
100* AR_19668381_ChIP-Seq_PC3_Human0.95011625
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93693419
102RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92340593
103FOXA1_25552417_ChIP-Seq_VCAP_Human0.91444663
104PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88327469
105PIAS1_25552417_ChIP-Seq_VCAP_Human0.88189334
106CDX2_22108803_ChIP-Seq_LS180_Human0.87719000
107* CJUN_26792858_Chip-Seq_BT549_Human0.87635995
108* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87461401
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83357936
110CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82751480
111* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82150154
112* TP63_23658742_ChIP-Seq_EP156T_Human0.80748607
113* SOX2_20726797_ChIP-Seq_SW620_Human0.79954694
114PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79918248
115FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79835899
116FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76955305
117GATA1_19941826_ChIP-Seq_K562_Human0.76617632
118KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76252641
119ZNF263_19887448_ChIP-Seq_K562_Human0.75959453
120GATA2_19941826_ChIP-Seq_K562_Human0.75622211
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75134821
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74257050
123* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.74093978
124ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73722622
125BCAT_22108803_ChIP-Seq_LS180_Human0.73598936
126AHR_22903824_ChIP-Seq_MCF-7_Human0.71870124
127GATA3_24758297_ChIP-Seq_MCF-7_Human0.69339986
128GATA6_25053715_ChIP-Seq_YYC3_Human0.69279293
129CBP_21632823_ChIP-Seq_H3396_Human0.67467990
130GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.67326403
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.66956451
132ARNT_22903824_ChIP-Seq_MCF-7_Human0.66829533
133* STAT1_17558387_ChIP-Seq_HELA_Human0.66667713
134* SMAD4_21741376_ChIP-Seq_HESCs_Human0.66015238
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64825432
136PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.63964198
137PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.63950251
138FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.62487283
139FOXH1_21741376_ChIP-Seq_EPCs_Human0.62166511
140RXRA_24833708_ChIP-Seq_LIVER_Mouse0.61934633
141CTNNB1_20460455_ChIP-Seq_HCT116_Human0.61906886
142NFYA_21822215_ChIP-Seq_K562_Human0.61703874
143ISL1_27105846_Chip-Seq_CPCs_Mouse0.61277613
144NFIB_24661679_ChIP-Seq_LUNG_Mouse0.60998966
145SMAD4_21741376_ChIP-Seq_EPCs_Human0.60380051
146TBL1_22424771_ChIP-Seq_293T_Human0.60256887
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.59601570
148ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.58361265
149* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.57509925
150RXR_22108803_ChIP-Seq_LS180_Human0.56723797
151* ESET_19884257_ChIP-Seq_ESCs_Mouse0.56484623
152CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.56033766

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.56042087
2MP0005360_urolithiasis6.02486375
3MP0005085_abnormal_gallbladder_physiolo5.49295693
4MP0005365_abnormal_bile_salt5.36497566
5MP0008875_abnormal_xenobiotic_pharmacok4.37375975
6MP0003252_abnormal_bile_duct3.61115937
7MP0003806_abnormal_nucleotide_metabolis3.23442829
8MP0009780_abnormal_chondrocyte_physiolo3.23095360
9MP0010329_abnormal_lipoprotein_level3.05159381
10MP0005083_abnormal_biliary_tract2.85849648
11MP0009840_abnormal_foam_cell2.84249062
12MP0003191_abnormal_cellular_cholesterol2.63670609
13MP0004270_analgesia2.60307300
14MP0005332_abnormal_amino_acid2.39965888
15MP0002837_dystrophic_cardiac_calcinosis2.37833372
16MP0001666_abnormal_nutrient_absorption2.37238229
17MP0005451_abnormal_body_composition2.24974600
18MP0002118_abnormal_lipid_homeostasis2.11310290
19MP0005409_darkened_coat_color1.92772196
20MP0003195_calcinosis1.84634675
21MP0000609_abnormal_liver_physiology1.84395821
22MP0010368_abnormal_lymphatic_system1.84341069
23MP0004130_abnormal_muscle_cell1.77089849
24MP0003646_muscle_fatigue1.67567572
25MP0005670_abnormal_white_adipose1.65248094
26MP0004084_abnormal_cardiac_muscle1.60301953
27MP0003879_abnormal_hair_cell1.59981410
28MP0001879_abnormal_lymphatic_vessel1.58277579
29MP0004036_abnormal_muscle_relaxation1.54948271
30MP0004019_abnormal_vitamin_homeostasis1.54011516
31MP0005319_abnormal_enzyme/_coenzyme1.53097545
32MP0003868_abnormal_feces_composition1.45774683
33MP0000566_synostosis1.43096310
34MP0001486_abnormal_startle_reflex1.40522466
35MP0004185_abnormal_adipocyte_glucose1.38946467
36MP0003705_abnormal_hypodermis_morpholog1.35970052
37MP0005666_abnormal_adipose_tissue1.35952451
38MP0002106_abnormal_muscle_physiology1.33308155
39MP0004272_abnormal_basement_membrane1.32103836
40MP0005584_abnormal_enzyme/coenzyme_acti1.28823011
41MP0003718_maternal_effect1.25956214
42MP0009643_abnormal_urine_homeostasis1.23649753
43MP0003690_abnormal_glial_cell1.23553027
44MP0004859_abnormal_synaptic_plasticity1.23225967
45MP0005369_muscle_phenotype1.23208251
46MP0002971_abnormal_brown_adipose1.22567071
47MP0002909_abnormal_adrenal_gland1.21602073
48MP0002138_abnormal_hepatobiliary_system1.20326501
49MP0002127_abnormal_cardiovascular_syste1.19726046
50MP0003656_abnormal_erythrocyte_physiolo1.19212095
51MP0004215_abnormal_myocardial_fiber1.16741936
52MP0000013_abnormal_adipose_tissue1.15051488
53MP0002272_abnormal_nervous_system1.14659699
54MP0001502_abnormal_circadian_rhythm1.14073665
55MP0006138_congestive_heart_failure1.13673791
56MP0005330_cardiomyopathy1.13552541
57MP0002332_abnormal_exercise_endurance1.12963173
58MP0004233_abnormal_muscle_weight1.11006549
59MP0001501_abnormal_sleep_pattern1.10935451
60MP0005647_abnormal_sex_gland1.10837259
61MP0000920_abnormal_myelination1.09209668
62MP0002108_abnormal_muscle_morphology1.08073017
63MP0002734_abnormal_mechanical_nocicepti1.07603118
64MP0005167_abnormal_blood-brain_barrier1.07490094
65MP0002064_seizures1.06255815
66MP0010678_abnormal_skin_adnexa1.05529375
67MP0001764_abnormal_homeostasis1.04218791
68MP0000759_abnormal_skeletal_muscle1.03945554
69MP0009384_cardiac_valve_regurgitation1.01129702
70MP0005408_hypopigmentation1.00127523
71MP0002972_abnormal_cardiac_muscle0.95750816
72MP0003635_abnormal_synaptic_transmissio0.95029028
73MP0000604_amyloidosis0.94086064
74MP0005620_abnormal_muscle_contractility0.93623655
75MP0009697_abnormal_copulation0.93573660
76MP0003329_amyloid_beta_deposits0.93371905
77MP0004087_abnormal_muscle_fiber0.93092274
78MP0003633_abnormal_nervous_system0.92760443
79MP0008569_lethality_at_weaning0.91958894
80MP0003950_abnormal_plasma_membrane0.91648527
81MP0009764_decreased_sensitivity_to0.91559691
82MP0001984_abnormal_olfaction0.90412597
83MP0003221_abnormal_cardiomyocyte_apopto0.90277641
84MP0000579_abnormal_nail_morphology0.90247524
85MP0003186_abnormal_redox_activity0.90085202
86MP0005423_abnormal_somatic_nervous0.89802646
87MP0000598_abnormal_liver_morphology0.88871526
88MP0008775_abnormal_heart_ventricle0.88626274
89MP0004147_increased_porphyrin_level0.88546015
90MP0002876_abnormal_thyroid_physiology0.88537705
91MP0010352_gastrointestinal_tract_polyps0.87563480
92MP0006036_abnormal_mitochondrial_physio0.87246336
93MP0005187_abnormal_penis_morphology0.86294141
94MP0005395_other_phenotype0.83345696
95MP0009046_muscle_twitch0.83044569
96MP0000751_myopathy0.82873297
97MP0005058_abnormal_lysosome_morphology0.82733169
98MP0000003_abnormal_adipose_tissue0.82633850
99MP0002063_abnormal_learning/memory/cond0.82440661
100MP0002078_abnormal_glucose_homeostasis0.81643154
101MP0001544_abnormal_cardiovascular_syste0.81316418
102MP0005385_cardiovascular_system_phenoty0.81316418
103MP0000762_abnormal_tongue_morphology0.80392613
104MP0005375_adipose_tissue_phenotype0.79942479
105MP0010630_abnormal_cardiac_muscle0.79719618
106MP0004264_abnormal_extraembryonic_tissu0.79416120
107MP0001661_extended_life_span0.79125899
108MP0009763_increased_sensitivity_to0.78838926
109MP0009745_abnormal_behavioral_response0.78634218
110MP0000230_abnormal_systemic_arterial0.75982520
111MP0000749_muscle_degeneration0.75913970
112MP0001664_abnormal_digestion0.75481391
113MP0002896_abnormal_bone_mineralization0.75154239
114MP0005646_abnormal_pituitary_gland0.74616393
115MP0000462_abnormal_digestive_system0.74093701
116MP0005334_abnormal_fat_pad0.73646542
117MP0003045_fibrosis0.72879552
118MP0002269_muscular_atrophy0.72169509
119MP0004924_abnormal_behavior0.71510622
120MP0005386_behavior/neurological_phenoty0.71510622
121MP0001756_abnormal_urination0.71436802
122MP0004043_abnormal_pH_regulation0.71108791
123MP0000383_abnormal_hair_follicle0.71084555
124MP0004782_abnormal_surfactant_physiolog0.70496745
125MP0003631_nervous_system_phenotype0.69817381
126MP0005220_abnormal_exocrine_pancreas0.68522270
127MP0009642_abnormal_blood_homeostasis0.68278736
128MP0000639_abnormal_adrenal_gland0.67882869
129MP0004145_abnormal_muscle_electrophysio0.67776092
130MP0005535_abnormal_body_temperature0.67528633
131MP0005165_increased_susceptibility_to0.66826844
132MP0005636_abnormal_mineral_homeostasis0.66636937
133MP0005376_homeostasis/metabolism_phenot0.66002572
134MP0004484_altered_response_of0.64871087
135MP0000747_muscle_weakness0.64767600
136MP0003011_delayed_dark_adaptation0.62390299
137MP0004883_abnormal_blood_vessel0.61165501
138MP0004085_abnormal_heartbeat0.61078560
139MP0003137_abnormal_impulse_conducting0.59619470
140MP0009115_abnormal_fat_cell0.56984512
141MP0003724_increased_susceptibility_to0.56444531
142MP0005266_abnormal_metabolism0.55146031
143MP0005084_abnormal_gallbladder_morpholo0.54135067
144MP0010234_abnormal_vibrissa_follicle0.52972947
145MP0003075_altered_response_to0.52944444
146MP0005595_abnormal_vascular_smooth0.52554658
147MP0002295_abnormal_pulmonary_circulatio0.52000911
148MP0000249_abnormal_blood_vessel0.51472608

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.44265253
2Intrahepatic cholestasis (HP:0001406)5.95334063
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.38050889
4Complement deficiency (HP:0004431)5.23263807
5Xanthomatosis (HP:0000991)5.21136709
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.85876525
7Hyperlipoproteinemia (HP:0010980)4.69401231
8Bundle branch block (HP:0011710)4.63284959
9Prolonged partial thromboplastin time (HP:0003645)4.52494325
10Hyperammonemia (HP:0001987)4.34342570
11Hypobetalipoproteinemia (HP:0003563)4.19212089
12Ketosis (HP:0001946)4.18343056
13Hyperglycinuria (HP:0003108)4.13926836
14Hypoalphalipoproteinemia (HP:0003233)4.09623200
15Abnormality of glycine metabolism (HP:0010895)4.03263726
16Abnormality of serine family amino acid metabolism (HP:0010894)4.03263726
17Hyperglycinemia (HP:0002154)4.02669875
18Hypoglycemic coma (HP:0001325)4.01276594
19Hypolipoproteinemia (HP:0010981)3.89134339
20Abnormality of the common coagulation pathway (HP:0010990)3.78155152
21Muscle fiber inclusion bodies (HP:0100299)3.75888724
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.68345642
23Abnormality of fatty-acid metabolism (HP:0004359)3.66590570
24Epidermoid cyst (HP:0200040)3.64432552
25Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.56859787
26Nemaline bodies (HP:0003798)3.56023430
27Abnormality of complement system (HP:0005339)3.55857113
28Ketoacidosis (HP:0001993)3.48213022
29Joint hemorrhage (HP:0005261)3.46682382
30Fat malabsorption (HP:0002630)3.39032453
31Abnormality of glutamine family amino acid metabolism (HP:0010902)3.30727692
32Abnormality of sulfur amino acid metabolism (HP:0004339)3.26745845
33Abnormality of the intrinsic pathway (HP:0010989)3.24427320
34Abnormality of aspartate family amino acid metabolism (HP:0010899)3.24108295
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.20378151
36EMG: myopathic abnormalities (HP:0003458)3.13845739
37Abnormality of the calf musculature (HP:0001430)3.07172666
38Abnormality of methionine metabolism (HP:0010901)3.04208437
39Systemic lupus erythematosus (HP:0002725)3.02361923
40Heart block (HP:0012722)2.95976317
41Type 1 muscle fiber predominance (HP:0003803)2.92490179
42Muscle hypertrophy of the lower extremities (HP:0008968)2.85939908
43Atrial fibrillation (HP:0005110)2.85733635
44Hyperglycemia (HP:0003074)2.84994675
45Gout (HP:0001997)2.84967995
46Hypercholesterolemia (HP:0003124)2.81944950
47Abnormal atrioventricular conduction (HP:0005150)2.81436022
48Dicarboxylic aciduria (HP:0003215)2.76766825
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.76766825
50Abnormality of purine metabolism (HP:0004352)2.76573991
51Difficulty running (HP:0009046)2.75206858
52Calf muscle hypertrophy (HP:0008981)2.74919956
53Glomerulonephritis (HP:0000099)2.70919010
54Conjugated hyperbilirubinemia (HP:0002908)2.70917062
55Myocardial infarction (HP:0001658)2.66875874
56Skin nodule (HP:0200036)2.65866707
57Hyperkalemia (HP:0002153)2.63716166
58Ventricular fibrillation (HP:0001663)2.61608588
59Right ventricular cardiomyopathy (HP:0011663)2.60831854
60Subaortic stenosis (HP:0001682)2.60449488
61Abnormality of the left ventricular outflow tract (HP:0011103)2.60449488
62Abnormality of serum amino acid levels (HP:0003112)2.58521272
63Metabolic acidosis (HP:0001942)2.58006284
64Malnutrition (HP:0004395)2.57326390
65Steatorrhea (HP:0002570)2.51983445
66Abnormality of nucleobase metabolism (HP:0010932)2.50952036
67Amyloidosis (HP:0011034)2.49463098
68Distal lower limb muscle weakness (HP:0009053)2.47797388
69Neck muscle weakness (HP:0000467)2.47726317
70Action tremor (HP:0002345)2.46951570
71Primary atrial arrhythmia (HP:0001692)2.46295787
72Myoglobinuria (HP:0002913)2.39087449
73Abnormal gallbladder morphology (HP:0012437)2.37382697
74Hyperbilirubinemia (HP:0002904)2.36466871
75Sensorimotor neuropathy (HP:0007141)2.35174053
76Hepatocellular carcinoma (HP:0001402)2.34795535
77Cholelithiasis (HP:0001081)2.34654250
78Cholecystitis (HP:0001082)2.32892071
79Abnormal gallbladder physiology (HP:0012438)2.32892071
80Vascular calcification (HP:0004934)2.32637606
81Sudden death (HP:0001699)2.31843099
82Papillary thyroid carcinoma (HP:0002895)2.31029451
83Centrally nucleated skeletal muscle fibers (HP:0003687)2.30572016
84Supraventricular tachycardia (HP:0004755)2.29517710
85Esophageal varix (HP:0002040)2.28600080
86Supraventricular arrhythmia (HP:0005115)2.28107735
87Dilated cardiomyopathy (HP:0001644)2.25885262
88Muscle fiber splitting (HP:0003555)2.25862952
89Exercise-induced myalgia (HP:0003738)2.23262192
90Dysmetric saccades (HP:0000641)2.19483326
91Lethargy (HP:0001254)2.19295718
92Lipoatrophy (HP:0100578)2.19255789
93Hyperactive renin-angiotensin system (HP:0000841)2.18819830
94EMG: neuropathic changes (HP:0003445)2.18619700
95Polycythemia (HP:0001901)2.16824433
96Generalized aminoaciduria (HP:0002909)2.16702103
97Delayed CNS myelination (HP:0002188)2.16535093
98Spontaneous abortion (HP:0005268)2.15363496
99Increased purine levels (HP:0004368)2.14116827
100Hyperuricemia (HP:0002149)2.14116827
101Ventricular tachycardia (HP:0004756)2.12807291
102Hemorrhage of the eye (HP:0011885)2.12216874
103Hypoglycemic seizures (HP:0002173)2.11596815
104Hyporeflexia of lower limbs (HP:0002600)2.10145199
105Hyperinsulinemic hypoglycemia (HP:0000825)2.09946415
106Cardiovascular calcification (HP:0011915)2.09748678
107Insulin-resistant diabetes mellitus (HP:0000831)2.08048563
108Recurrent gram-negative bacterial infections (HP:0005420)2.02643672
109Atrioventricular block (HP:0001678)2.01708136
110Exercise-induced muscle cramps (HP:0003710)2.01255075
111Syncope (HP:0001279)2.00885568
112Proximal tubulopathy (HP:0000114)2.00454736
113Abnormality of pyrimidine metabolism (HP:0004353)1.99708127
114Cortical dysplasia (HP:0002539)1.98334886
115Decreased circulating renin level (HP:0003351)1.97857752
116Hypochromic microcytic anemia (HP:0004840)1.97741938
117Abnormality of the foot musculature (HP:0001436)1.94214777
118Late onset (HP:0003584)1.92968553
119Nephritis (HP:0000123)1.92844604
120Foot dorsiflexor weakness (HP:0009027)1.89736567
121Pancreatitis (HP:0001733)1.89724997
122Rhabdomyolysis (HP:0003201)1.89149535
123Irritability (HP:0000737)1.85541230
124Acanthocytosis (HP:0001927)1.85448437
125Increased connective tissue (HP:0009025)1.84116478
126Axonal loss (HP:0003447)1.83944402
127Ankle clonus (HP:0011448)1.83465817
128Myotonia (HP:0002486)1.83219699
129Febrile seizures (HP:0002373)1.83077133
130Vomiting (HP:0002013)1.82369292
131Distal arthrogryposis (HP:0005684)1.81657765
132Round ear (HP:0100830)1.81522595
133Frequent falls (HP:0002359)1.80526172
134Mildly elevated creatine phosphokinase (HP:0008180)1.80130652
135Cerebral hemorrhage (HP:0001342)1.79664243
136Polar cataract (HP:0010696)1.79197472
137Scanning speech (HP:0002168)1.79192570
138Hydroxyprolinuria (HP:0003080)1.78886460
139Abnormality of proline metabolism (HP:0010907)1.78886460
140Abnormality of the gallbladder (HP:0005264)1.78727799
141Increased circulating renin level (HP:0000848)1.78468289
142Neurofibrillary tangles (HP:0002185)1.78406044
143Abnormality of renin-angiotensin system (HP:0000847)1.76942139
144Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.75692173
145Ventricular arrhythmia (HP:0004308)1.75354583
146Asymmetric septal hypertrophy (HP:0001670)1.73546041
147Hyperaldosteronism (HP:0000859)1.73337537
148Abnormal cartilage morphology (HP:0002763)1.72797757
149Blue irides (HP:0000635)1.72201189
150Limited hip movement (HP:0008800)1.70667495
151Neonatal death (HP:0003811)1.68348086
152Palpitations (HP:0001962)1.68321798
153Myopathic facies (HP:0002058)1.68271930
154Skin pits (HP:0100276)1.67764400
155Focal motor seizures (HP:0011153)1.67737367
156Lymphangioma (HP:0100764)1.67098025
157Visceral angiomatosis (HP:0100761)1.66415162
158Prolonged QT interval (HP:0001657)1.65072225
159Focal seizures (HP:0007359)1.64863626
160Rimmed vacuoles (HP:0003805)1.63712319
161Abnormality of potassium homeostasis (HP:0011042)1.62336956
162Alacrima (HP:0000522)1.61543816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.04299876
2BCKDK3.49369892
3TAOK33.43210030
4ERN12.52905867
5STK38L2.44507103
6TIE12.39278496
7NTRK32.20939879
8EPHB12.16881803
9ERBB42.16505218
10SIK12.14921725
11TRIB32.10072808
12LATS22.04842037
13MARK11.90798759
14INSRR1.88820404
15PDK21.87425179
16MAP3K61.77163964
17OBSCN1.75539348
18EPHA21.69955920
19LMTK21.65412798
20AKT31.65374721
21FGFR41.63671928
22PIK3CA1.63079400
23PRKAA21.61467518
24KSR21.61090458
25TGFBR21.61021360
26STK391.60488962
27MST1R1.58983815
28CAMK1D1.58896785
29PHKG11.50768879
30PHKG21.50768879
31PKN21.45428770
32MAP2K41.40854207
33RIPK11.39611784
34NEK61.36344845
35FGFR21.36310350
36DMPK1.33710061
37EPHA41.33530404
38CASK1.33489939
39PINK11.29420846
40TTN1.29211734
41FRK1.26132266
42MET1.22871940
43PRKAA11.21927930
44KDR1.15816024
45STK31.13497425
46CAMK1G1.13067812
47FGFR31.07761544
48EEF2K1.05465313
49PTK61.04835751
50MYLK1.03533141
51NEK91.01250131
52WNK40.99613787
53NTRK20.97596202
54OXSR10.97275745
55TAOK10.96732144
56CAMK2D0.96731851
57CAMK2B0.96715622
58RET0.94529918
59STK380.92715011
60PDK30.92288309
61PDK40.92288309
62MAPK110.91500403
63MAPK120.90167605
64PDPK10.89210114
65UHMK10.88840482
66SGK4940.88760320
67SGK2230.88760320
68ABL20.87614017
69PRKD10.86766943
70ICK0.84828332
71JAK20.83598585
72MAP3K120.82176490
73PIK3CG0.80418517
74CAMK2A0.78618981
75MAP2K30.78249792
76MAPK150.77805907
77MAP3K70.76908860
78ERBB30.76762889
79PRKCE0.75302013
80NTRK10.72938006
81PKN10.72564107
82CAMK40.70304826
83STK240.69145909
84SGK30.66929116
85BMPR1B0.66853198
86MAP3K20.65558388
87STK100.64384949
88CDK50.62832419
89PTK20.62577649
90ERBB20.61732046
91CAMK10.60870266
92TRPM70.59709816
93GSK3A0.57279182
94AKT20.56955211
95PRKG20.56793134
96WNK10.56646388
97PAK60.56347594
98SGK20.56346015
99SGK10.55991684
100MARK20.55860671
101PRKG10.55525645
102CDC42BPA0.55337327
103PAK30.55136229
104NLK0.54671516
105ROCK20.54019162
106TNIK0.53373595
107MELK0.53193768
108EPHA30.52721755
109MAPKAPK30.51999493
110PDK10.51005977
111PDGFRA0.50555036
112MAPK100.49860593
113MUSK0.49763966
114PNCK0.49634204
115JAK10.49514337
116RPS6KA30.49432822
117ACVR1B0.48713429
118CAMK2G0.48432047
119MTOR0.47928127
120CSNK1G10.47872419
121MAP2K20.47808712
122PRKD30.46668120
123MAP3K30.46254166
124CDK90.44322948
125DAPK20.43388273
126MAP2K10.41920390
127FER0.40856524
128ROCK10.40360227
129PDGFRB0.39476432
130MAP3K10.39347750
131PRKACG0.39195894
132PRKCZ0.37813122
133PRKACB0.37720796
134MOS0.37511203
135MAP3K50.37391747
136EPHB20.36415138
137MAPK40.34096242
138MAP3K90.34042904

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.59945082
2Nitrogen metabolism_Homo sapiens_hsa009103.53456008
3Fatty acid degradation_Homo sapiens_hsa000712.81628327
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.81589881
5Arginine biosynthesis_Homo sapiens_hsa002202.78319346
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.72460654
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.68911698
8Propanoate metabolism_Homo sapiens_hsa006402.47294986
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45329148
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45085051
11Tryptophan metabolism_Homo sapiens_hsa003802.42497153
12Complement and coagulation cascades_Homo sapiens_hsa046102.39606535
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.22612139
14Butanoate metabolism_Homo sapiens_hsa006502.22198386
15Fatty acid metabolism_Homo sapiens_hsa012122.16660582
16PPAR signaling pathway_Homo sapiens_hsa033202.03398352
17Peroxisome_Homo sapiens_hsa041461.89236084
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.89170695
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88553923
20Histidine metabolism_Homo sapiens_hsa003401.85657116
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77011074
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76605849
23beta-Alanine metabolism_Homo sapiens_hsa004101.74917491
24Staphylococcus aureus infection_Homo sapiens_hsa051501.70033161
25Pancreatic secretion_Homo sapiens_hsa049721.59912643
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56993616
27Caffeine metabolism_Homo sapiens_hsa002321.55443292
28Fatty acid elongation_Homo sapiens_hsa000621.55439275
29Chemical carcinogenesis_Homo sapiens_hsa052041.55304184
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53344545
31Bile secretion_Homo sapiens_hsa049761.52246971
32Sulfur metabolism_Homo sapiens_hsa009201.50670557
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.49421608
34Pyruvate metabolism_Homo sapiens_hsa006201.42942788
35Starch and sucrose metabolism_Homo sapiens_hsa005001.39452682
36Retinol metabolism_Homo sapiens_hsa008301.33734365
37Carbon metabolism_Homo sapiens_hsa012001.25934915
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25355716
39Renin secretion_Homo sapiens_hsa049241.25113131
40Fat digestion and absorption_Homo sapiens_hsa049751.23953698
41ABC transporters_Homo sapiens_hsa020101.21408511
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20726817
43Phenylalanine metabolism_Homo sapiens_hsa003601.20114320
44Insulin secretion_Homo sapiens_hsa049111.18034285
45Tyrosine metabolism_Homo sapiens_hsa003501.17680961
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16871901
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14737332
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11450010
49Vitamin B6 metabolism_Homo sapiens_hsa007501.11387751
50Gastric acid secretion_Homo sapiens_hsa049711.05400557
51Biosynthesis of amino acids_Homo sapiens_hsa012301.05153370
52Arginine and proline metabolism_Homo sapiens_hsa003301.04765325
53Tight junction_Homo sapiens_hsa045301.03419297
54Cardiac muscle contraction_Homo sapiens_hsa042601.03079864
55Lysine degradation_Homo sapiens_hsa003101.01376863
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.99817684
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98178198
58Selenocompound metabolism_Homo sapiens_hsa004500.97096880
59Fatty acid biosynthesis_Homo sapiens_hsa000610.96175368
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95910885
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.95706948
62Adherens junction_Homo sapiens_hsa045200.93055103
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92844992
64GABAergic synapse_Homo sapiens_hsa047270.92727892
65Steroid biosynthesis_Homo sapiens_hsa001000.91809487
66Long-term potentiation_Homo sapiens_hsa047200.91500576
67Circadian entrainment_Homo sapiens_hsa047130.90655698
68Glycerolipid metabolism_Homo sapiens_hsa005610.89597862
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88982044
70Amphetamine addiction_Homo sapiens_hsa050310.88201196
71Vitamin digestion and absorption_Homo sapiens_hsa049770.88114962
72Glutamatergic synapse_Homo sapiens_hsa047240.87978022
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.87866744
74Salivary secretion_Homo sapiens_hsa049700.86567275
75Folate biosynthesis_Homo sapiens_hsa007900.84614787
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82059941
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.79703668
78Nicotine addiction_Homo sapiens_hsa050330.78502886
79Synaptic vesicle cycle_Homo sapiens_hsa047210.75186537
80ECM-receptor interaction_Homo sapiens_hsa045120.73897171
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69968754
82Calcium signaling pathway_Homo sapiens_hsa040200.69587213
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69216654
84Oxytocin signaling pathway_Homo sapiens_hsa049210.67784426
85cAMP signaling pathway_Homo sapiens_hsa040240.67626447
86Glutathione metabolism_Homo sapiens_hsa004800.66980731
87Morphine addiction_Homo sapiens_hsa050320.65555777
88Cocaine addiction_Homo sapiens_hsa050300.63982966
89Dopaminergic synapse_Homo sapiens_hsa047280.62221099
90GnRH signaling pathway_Homo sapiens_hsa049120.59228703
91Insulin resistance_Homo sapiens_hsa049310.59040700
92Gap junction_Homo sapiens_hsa045400.58162431
93Renin-angiotensin system_Homo sapiens_hsa046140.58148881
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57925057
95Ovarian steroidogenesis_Homo sapiens_hsa049130.56742127
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56573641
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54601707
98Pentose phosphate pathway_Homo sapiens_hsa000300.53053796
99Sulfur relay system_Homo sapiens_hsa041220.52518995
100Focal adhesion_Homo sapiens_hsa045100.52102205
101Estrogen signaling pathway_Homo sapiens_hsa049150.51522835
102Serotonergic synapse_Homo sapiens_hsa047260.48939265
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48077497
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.47617596
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.46587540
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.45079228
107Linoleic acid metabolism_Homo sapiens_hsa005910.44554391
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43809729
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43223663
110AMPK signaling pathway_Homo sapiens_hsa041520.35698156
111Metabolic pathways_Homo sapiens_hsa011000.35352082
112Ether lipid metabolism_Homo sapiens_hsa005650.32202798
113Glucagon signaling pathway_Homo sapiens_hsa049220.30779041
114Circadian rhythm_Homo sapiens_hsa047100.27910498
115Prion diseases_Homo sapiens_hsa050200.25997161
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25839340
117Dorso-ventral axis formation_Homo sapiens_hsa043200.25743314
118Insulin signaling pathway_Homo sapiens_hsa049100.22155764
119Fructose and mannose metabolism_Homo sapiens_hsa000510.18170741
120Dilated cardiomyopathy_Homo sapiens_hsa054140.17683629
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17309544
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.16941157
123Galactose metabolism_Homo sapiens_hsa000520.16515959
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.11385676
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10044085
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.09863889
127Mineral absorption_Homo sapiens_hsa049780.09836312
128Other glycan degradation_Homo sapiens_hsa005110.08173880
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08079893
130Protein digestion and absorption_Homo sapiens_hsa049740.06730466
131Arachidonic acid metabolism_Homo sapiens_hsa005900.06615584
132Type II diabetes mellitus_Homo sapiens_hsa049300.06250628
133Amoebiasis_Homo sapiens_hsa051460.05506972
134Thyroid hormone synthesis_Homo sapiens_hsa049180.05251612
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.03587941
136Pancreatic cancer_Homo sapiens_hsa05212-0.0094960

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