

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | cardiac myofibril assembly (GO:0055003) | 6.11961078 |
| 2 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 5.91423225 |
| 3 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 5.57059897 |
| 4 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 5.54857840 |
| 5 | sarcomere organization (GO:0045214) | 5.54420968 |
| 6 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 5.42822277 |
| 7 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 5.41629638 |
| 8 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 5.32111070 |
| 9 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 5.24380691 |
| 10 | cardiac muscle contraction (GO:0060048) | 5.07352052 |
| 11 | myofibril assembly (GO:0030239) | 5.02239060 |
| 12 | cell communication by electrical coupling (GO:0010644) | 4.90930837 |
| 13 | cell communication involved in cardiac conduction (GO:0086065) | 4.72607862 |
| 14 | regulation of membrane repolarization (GO:0060306) | 4.71351035 |
| 15 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 4.64925182 |
| 16 | ventricular cardiac muscle cell action potential (GO:0086005) | 4.60333235 |
| 17 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.52589734 |
| 18 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 4.49999335 |
| 19 | regulation of actin filament-based movement (GO:1903115) | 4.36424930 |
| 20 | regulation of cell communication by electrical coupling (GO:0010649) | 4.34494458 |
| 21 | regulation of sarcomere organization (GO:0060297) | 4.34338154 |
| 22 | cardiac muscle cell development (GO:0055013) | 4.31848087 |
| 23 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 4.28679092 |
| 24 | cardiac muscle hypertrophy (GO:0003300) | 4.23969004 |
| 25 | regulation of relaxation of muscle (GO:1901077) | 4.19081476 |
| 26 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 4.15182680 |
| 27 | tricarboxylic acid cycle (GO:0006099) | 4.14985110 |
| 28 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 4.08563840 |
| 29 | cardiac cell development (GO:0055006) | 4.00403539 |
| 30 | striated muscle hypertrophy (GO:0014897) | 4.00255798 |
| 31 | adult heart development (GO:0007512) | 3.88014883 |
| 32 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 3.80264294 |
| 33 | vocalization behavior (GO:0071625) | 3.76589476 |
| 34 | regulation of the force of heart contraction (GO:0002026) | 3.76431055 |
| 35 | cardiac muscle tissue morphogenesis (GO:0055008) | 3.76143039 |
| 36 | cardiac conduction (GO:0061337) | 3.74483888 |
| 37 | plasma membrane repair (GO:0001778) | 3.73010452 |
| 38 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.71120524 |
| 39 | striated muscle contraction (GO:0006941) | 3.70536737 |
| 40 | cardiac muscle cell action potential (GO:0086001) | 3.70187260 |
| 41 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 3.68844481 |
| 42 | regulation of striated muscle contraction (GO:0006942) | 3.68062068 |
| 43 | actomyosin structure organization (GO:0031032) | 3.67584165 |
| 44 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.67496668 |
| 45 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 3.66707128 |
| 46 | detection of calcium ion (GO:0005513) | 3.65165878 |
| 47 | regulation of heart rate by cardiac conduction (GO:0086091) | 3.65140246 |
| 48 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.61773496 |
| 49 | dendritic spine morphogenesis (GO:0060997) | 3.61426503 |
| 50 | relaxation of cardiac muscle (GO:0055119) | 3.59845906 |
| 51 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 3.56239769 |
| 52 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.55790204 |
| 53 | regulation of cardiac muscle contraction (GO:0055117) | 3.53788644 |
| 54 | actin-myosin filament sliding (GO:0033275) | 3.53542839 |
| 55 | muscle filament sliding (GO:0030049) | 3.53542839 |
| 56 | positive regulation of synapse maturation (GO:0090129) | 3.51960731 |
| 57 | cardiac chamber formation (GO:0003207) | 3.49176341 |
| 58 | regulation of cardiac muscle cell contraction (GO:0086004) | 3.48582997 |
| 59 | regulation of synapse structural plasticity (GO:0051823) | 3.47896009 |
| 60 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 3.46273926 |
| 61 | potassium ion export (GO:0071435) | 3.45785761 |
| 62 | positive regulation of action potential (GO:0045760) | 3.44484167 |
| 63 | muscle hypertrophy (GO:0014896) | 3.43452721 |
| 64 | regulation of heart rate (GO:0002027) | 3.42815357 |
| 65 | positive regulation of heart rate (GO:0010460) | 3.41359826 |
| 66 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.41339218 |
| 67 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.41339218 |
| 68 | negative regulation of potassium ion transport (GO:0043267) | 3.39600533 |
| 69 | negative regulation of cardiac muscle cell apoptotic process (GO:0010667) | 3.36571118 |
| 70 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.35269604 |
| 71 | synaptic vesicle exocytosis (GO:0016079) | 3.35133332 |
| 72 | regulation of coenzyme metabolic process (GO:0051196) | 3.33627262 |
| 73 | regulation of cofactor metabolic process (GO:0051193) | 3.33627262 |
| 74 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.33045729 |
| 75 | membrane repolarization during cardiac muscle cell action potential (GO:0086013) | 3.31544145 |
| 76 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.31071564 |
| 77 | muscle tissue morphogenesis (GO:0060415) | 3.29539323 |
| 78 | synaptic vesicle maturation (GO:0016188) | 3.29220313 |
| 79 | heart trabecula formation (GO:0060347) | 3.27748104 |
| 80 | negative regulation of protein localization to cell surface (GO:2000009) | 3.22570309 |
| 81 | positive regulation of potassium ion transport (GO:0043268) | 3.21347315 |
| 82 | membrane depolarization during action potential (GO:0086010) | 3.20220870 |
| 83 | sodium ion export (GO:0071436) | 3.20068730 |
| 84 | regulation of potassium ion transmembrane transport (GO:1901379) | 3.19971003 |
| 85 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 3.19955981 |
| 86 | muscle hypertrophy in response to stress (GO:0003299) | 3.19955981 |
| 87 | cardiac muscle adaptation (GO:0014887) | 3.19955981 |
| 88 | cardiac ventricle formation (GO:0003211) | 3.18688525 |
| 89 | cellular potassium ion homeostasis (GO:0030007) | 3.18153052 |
| 90 | regulation of ATPase activity (GO:0043462) | 3.17339949 |
| 91 | regulation of ATP catabolic process (GO:1903289) | 3.17339949 |
| 92 | regulation of heart contraction (GO:0008016) | 3.17300507 |
| 93 | heart contraction (GO:0060047) | 3.16335732 |
| 94 | heart process (GO:0003015) | 3.16335732 |
| 95 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 3.16271978 |
| 96 | activation of protein kinase A activity (GO:0034199) | 3.15345099 |
| 97 | regulation of potassium ion transmembrane transporter activity (GO:1901016) | 3.15037051 |
| 98 | positive regulation of ATPase activity (GO:0032781) | 3.14203883 |
| 99 | positive regulation of ATP catabolic process (GO:1903291) | 3.14203883 |
| 100 | striatum development (GO:0021756) | 3.10580629 |
| 101 | membrane repolarization (GO:0086009) | 3.09889112 |
| 102 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 3.08817353 |
| 103 | protein localization to synapse (GO:0035418) | 3.08577123 |
| 104 | adrenergic receptor signaling pathway (GO:0071875) | 3.08056776 |
| 105 | chemosensory behavior (GO:0007635) | 3.07722483 |
| 106 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.06227870 |
| 107 | positive regulation of cation channel activity (GO:2001259) | 3.05504154 |
| 108 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.03086550 |
| 109 | neuronal ion channel clustering (GO:0045161) | 3.02066000 |
| 110 | membrane repolarization during action potential (GO:0086011) | 3.01256450 |
| 111 | actin-mediated cell contraction (GO:0070252) | 3.00456072 |
| 112 | regulation of action potential (GO:0098900) | 2.99756906 |
| 113 | urinary tract smooth muscle contraction (GO:0014848) | 2.99414551 |
| 114 | positive regulation of sodium ion transport (GO:0010765) | 2.97652264 |
| 115 | multicellular organismal signaling (GO:0035637) | 2.97584177 |
| 116 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 2.97348236 |
| 117 | regulation of synapse maturation (GO:0090128) | 2.95786800 |
| 118 | positive regulation of ion transmembrane transporter activity (GO:0032414) | 2.94396276 |
| 119 | negative regulation of heart rate (GO:0010459) | 2.92405135 |
| 120 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.86955554 |
| 121 | action potential (GO:0001508) | 2.81155391 |
| 122 | regulation of cardioblast differentiation (GO:0051890) | 2.78468622 |
| 123 | insulin secretion (GO:0030073) | 2.76263998 |
| 124 | neuronal action potential (GO:0019228) | 2.72964889 |
| 125 | positive regulation of heart contraction (GO:0045823) | 2.71865470 |
| 126 | negative regulation of hormone biosynthetic process (GO:0032353) | 2.67030791 |
| 127 | cAMP biosynthetic process (GO:0006171) | 2.64079836 |
| 128 | positive regulation of membrane potential (GO:0045838) | 2.62927725 |
| 129 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 2.57636500 |
| 130 | desmosome organization (GO:0002934) | 2.57585689 |
| 131 | presynaptic membrane organization (GO:0097090) | 2.57564198 |
| 132 | positive regulation of cardiac muscle cell differentiation (GO:2000727) | 2.57544552 |
| 133 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 2.56372373 |
| 134 | glutamate secretion (GO:0014047) | 2.55924317 |
| 135 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.55266010 |
| 136 | regulation of postsynaptic membrane potential (GO:0060078) | 2.55058557 |
| 137 | righting reflex (GO:0060013) | 2.53655371 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.17185714 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.15621497 |
| 3 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.71730245 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.64697980 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.63769462 |
| 6 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 2.44287575 |
| 7 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 2.42715397 |
| 8 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.42583517 |
| 9 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.41511001 |
| 10 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.41511001 |
| 11 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.34434941 |
| 12 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.33248921 |
| 13 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.21453062 |
| 14 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.19060001 |
| 15 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.16625924 |
| 16 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.11907416 |
| 17 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.09449059 |
| 18 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.07594188 |
| 19 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.05053327 |
| 20 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.03255847 |
| 21 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.98521846 |
| 22 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.96348857 |
| 23 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.96077246 |
| 24 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.89853433 |
| 25 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.89102076 |
| 26 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.88373530 |
| 27 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.85960612 |
| 28 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.75960089 |
| 29 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.66525525 |
| 30 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.64355225 |
| 31 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.64080899 |
| 32 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 1.62711197 |
| 33 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.60965620 |
| 34 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.60570424 |
| 35 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.59210450 |
| 36 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.57666269 |
| 37 | * SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.56525728 |
| 38 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.52818112 |
| 39 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.51663665 |
| 40 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.48922953 |
| 41 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.48785527 |
| 42 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.47975995 |
| 43 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.47290722 |
| 44 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.44599952 |
| 45 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.41854202 |
| 46 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.40270919 |
| 47 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.38354149 |
| 48 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.38350636 |
| 49 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.37593422 |
| 50 | FUS_26573619_Chip-Seq_HEK293_Human | 1.35592945 |
| 51 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.35559004 |
| 52 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.34560629 |
| 53 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.34104826 |
| 54 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.33815469 |
| 55 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.33610434 |
| 56 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.32040436 |
| 57 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.32040436 |
| 58 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.26866589 |
| 59 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.26458762 |
| 60 | VDR_22108803_ChIP-Seq_LS180_Human | 1.25589789 |
| 61 | AR_19668381_ChIP-Seq_PC3_Human | 1.25340021 |
| 62 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.25014269 |
| 63 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.24946154 |
| 64 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.23250352 |
| 65 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.22003907 |
| 66 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.20907735 |
| 67 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.19784110 |
| 68 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.19721288 |
| 69 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.18385821 |
| 70 | * NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.18324899 |
| 71 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.16475844 |
| 72 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.15909677 |
| 73 | STAT3_23295773_ChIP-Seq_U87_Human | 1.15272466 |
| 74 | * LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.14538021 |
| 75 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.13601848 |
| 76 | P300_19829295_ChIP-Seq_ESCs_Human | 1.11920621 |
| 77 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.11865528 |
| 78 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.11279416 |
| 79 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.11220653 |
| 80 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.10987370 |
| 81 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.10721133 |
| 82 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.10457759 |
| 83 | TCF4_23295773_ChIP-Seq_U87_Human | 1.09265510 |
| 84 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.09088609 |
| 85 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.08695262 |
| 86 | * TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.08610376 |
| 87 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.08149142 |
| 88 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.07956768 |
| 89 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.07423819 |
| 90 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.07153949 |
| 91 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.06386581 |
| 92 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.06155378 |
| 93 | AR_25329375_ChIP-Seq_VCAP_Human | 1.05446109 |
| 94 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.04775256 |
| 95 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.04680016 |
| 96 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.04572923 |
| 97 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.04539949 |
| 98 | * RUNX2_22187159_ChIP-Seq_PCA_Human | 1.02461935 |
| 99 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.02452804 |
| 100 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.01410423 |
| 101 | * TBL1_22424771_ChIP-Seq_293T_Human | 1.01199372 |
| 102 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.01059105 |
| 103 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.00410957 |
| 104 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.00410957 |
| 105 | EWS_26573619_Chip-Seq_HEK293_Human | 0.99433013 |
| 106 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.99116998 |
| 107 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.98690910 |
| 108 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.98663384 |
| 109 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.98218511 |
| 110 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 0.98196320 |
| 111 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.97954361 |
| 112 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.97886359 |
| 113 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.95674756 |
| 114 | KDM2B_26808549_Chip-Seq_K562_Human | 0.95565883 |
| 115 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.95361632 |
| 116 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.94962618 |
| 117 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.94793435 |
| 118 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.94361547 |
| 119 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.93887304 |
| 120 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 0.91044250 |
| 121 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.90682800 |
| 122 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.89969439 |
| 123 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.89606906 |
| 124 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.89340931 |
| 125 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.89139690 |
| 126 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.89139690 |
| 127 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.88945321 |
| 128 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.88450998 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002837_dystrophic_cardiac_calcinosis | 5.30858619 |
| 2 | MP0004084_abnormal_cardiac_muscle | 4.52755423 |
| 3 | MP0003646_muscle_fatigue | 4.21425954 |
| 4 | MP0004215_abnormal_myocardial_fiber | 4.17824331 |
| 5 | MP0000751_myopathy | 3.96541990 |
| 6 | MP0004036_abnormal_muscle_relaxation | 3.37017694 |
| 7 | MP0004859_abnormal_synaptic_plasticity | 3.22300817 |
| 8 | MP0003137_abnormal_impulse_conducting | 2.76944184 |
| 9 | MP0003880_abnormal_central_pattern | 2.73119150 |
| 10 | MP0005330_cardiomyopathy | 2.71169804 |
| 11 | MP0002972_abnormal_cardiac_muscle | 2.51022881 |
| 12 | MP0008775_abnormal_heart_ventricle | 2.48274990 |
| 13 | MP0000749_muscle_degeneration | 2.47946694 |
| 14 | MP0003283_abnormal_digestive_organ | 2.34417100 |
| 15 | MP0003635_abnormal_synaptic_transmissio | 2.28442488 |
| 16 | MP0004085_abnormal_heartbeat | 2.23198616 |
| 17 | MP0004145_abnormal_muscle_electrophysio | 2.20595292 |
| 18 | MP0004484_altered_response_of | 2.20036669 |
| 19 | MP0005620_abnormal_muscle_contractility | 2.19054836 |
| 20 | MP0004087_abnormal_muscle_fiber | 2.04164118 |
| 21 | MP0009046_muscle_twitch | 1.99701917 |
| 22 | MP0003195_calcinosis | 1.99172369 |
| 23 | MP0004270_analgesia | 1.92585847 |
| 24 | MP0005385_cardiovascular_system_phenoty | 1.89512536 |
| 25 | MP0001544_abnormal_cardiovascular_syste | 1.89512536 |
| 26 | MP0009745_abnormal_behavioral_response | 1.80578394 |
| 27 | MP0006138_congestive_heart_failure | 1.80201798 |
| 28 | MP0002063_abnormal_learning/memory/cond | 1.79757329 |
| 29 | MP0004233_abnormal_muscle_weight | 1.77704524 |
| 30 | MP0002106_abnormal_muscle_physiology | 1.74085682 |
| 31 | MP0002822_catalepsy | 1.72472465 |
| 32 | MP0002064_seizures | 1.68642202 |
| 33 | MP0010630_abnormal_cardiac_muscle | 1.63889278 |
| 34 | MP0008877_abnormal_DNA_methylation | 1.63437756 |
| 35 | MP0002272_abnormal_nervous_system | 1.61765417 |
| 36 | MP0004510_myositis | 1.60093600 |
| 37 | MP0002734_abnormal_mechanical_nocicepti | 1.55896314 |
| 38 | MP0001968_abnormal_touch/_nociception | 1.55391978 |
| 39 | MP0002127_abnormal_cardiovascular_syste | 1.53185867 |
| 40 | MP0000750_abnormal_muscle_regeneration | 1.51616479 |
| 41 | MP0002269_muscular_atrophy | 1.49350892 |
| 42 | MP0002572_abnormal_emotion/affect_behav | 1.49079607 |
| 43 | MP0004130_abnormal_muscle_cell | 1.47198964 |
| 44 | MP0003121_genomic_imprinting | 1.47126509 |
| 45 | MP0001486_abnormal_startle_reflex | 1.43304205 |
| 46 | MP0005423_abnormal_somatic_nervous | 1.42417816 |
| 47 | MP0000569_abnormal_digit_pigmentation | 1.40835826 |
| 48 | MP0005369_muscle_phenotype | 1.40102502 |
| 49 | MP0002735_abnormal_chemical_nociception | 1.38364391 |
| 50 | MP0004924_abnormal_behavior | 1.37289684 |
| 51 | MP0005386_behavior/neurological_phenoty | 1.37289684 |
| 52 | MP0005551_abnormal_eye_electrophysiolog | 1.33830999 |
| 53 | MP0006276_abnormal_autonomic_nervous | 1.33332956 |
| 54 | MP0002067_abnormal_sensory_capabilities | 1.32038523 |
| 55 | MP0003221_abnormal_cardiomyocyte_apopto | 1.31809747 |
| 56 | MP0002909_abnormal_adrenal_gland | 1.30274567 |
| 57 | MP0001440_abnormal_grooming_behavior | 1.29878552 |
| 58 | MP0000759_abnormal_skeletal_muscle | 1.29377482 |
| 59 | MP0006072_abnormal_retinal_apoptosis | 1.28272007 |
| 60 | MP0002234_abnormal_pharynx_morphology | 1.27069019 |
| 61 | MP0001984_abnormal_olfaction | 1.26874340 |
| 62 | MP0003123_paternal_imprinting | 1.26562412 |
| 63 | MP0008569_lethality_at_weaning | 1.25128656 |
| 64 | MP0002184_abnormal_innervation | 1.25071190 |
| 65 | MP0000747_muscle_weakness | 1.23510633 |
| 66 | MP0001944_abnormal_pancreas_morphology | 1.22361452 |
| 67 | MP0001970_abnormal_pain_threshold | 1.12689788 |
| 68 | MP0002736_abnormal_nociception_after | 1.10783137 |
| 69 | MP0001529_abnormal_vocalization | 1.10176320 |
| 70 | MP0002332_abnormal_exercise_endurance | 1.09716815 |
| 71 | MP0003950_abnormal_plasma_membrane | 1.09588000 |
| 72 | MP0003828_pulmonary_edema | 1.09573366 |
| 73 | MP0002693_abnormal_pancreas_physiology | 1.08095464 |
| 74 | MP0002638_abnormal_pupillary_reflex | 1.06774326 |
| 75 | MP0005084_abnormal_gallbladder_morpholo | 1.05410430 |
| 76 | MP0000778_abnormal_nervous_system | 1.04737073 |
| 77 | MP0002102_abnormal_ear_morphology | 1.04319791 |
| 78 | MP0001986_abnormal_taste_sensitivity | 1.02058021 |
| 79 | MP0001502_abnormal_circadian_rhythm | 1.01548628 |
| 80 | MP0010234_abnormal_vibrissa_follicle | 0.98597425 |
| 81 | MP0002733_abnormal_thermal_nociception | 0.98517688 |
| 82 | MP0003879_abnormal_hair_cell | 0.98035975 |
| 83 | MP0010386_abnormal_urinary_bladder | 0.95424100 |
| 84 | MP0005645_abnormal_hypothalamus_physiol | 0.95184037 |
| 85 | MP0001501_abnormal_sleep_pattern | 0.93938150 |
| 86 | MP0006036_abnormal_mitochondrial_physio | 0.92203923 |
| 87 | MP0003122_maternal_imprinting | 0.91198296 |
| 88 | MP0002557_abnormal_social/conspecific_i | 0.90982749 |
| 89 | MP0006035_abnormal_mitochondrial_morpho | 0.89779111 |
| 90 | MP0008961_abnormal_basal_metabolism | 0.89322740 |
| 91 | MP0005379_endocrine/exocrine_gland_phen | 0.87368388 |
| 92 | MP0002882_abnormal_neuron_morphology | 0.87249671 |
| 93 | MP0004811_abnormal_neuron_physiology | 0.86995815 |
| 94 | MP0004147_increased_porphyrin_level | 0.86705082 |
| 95 | MP0002078_abnormal_glucose_homeostasis | 0.85203334 |
| 96 | MP0004858_abnormal_nervous_system | 0.84961467 |
| 97 | MP0002928_abnormal_bile_duct | 0.84831955 |
| 98 | MP0002066_abnormal_motor_capabilities/c | 0.84261151 |
| 99 | MP0003119_abnormal_digestive_system | 0.83789676 |
| 100 | MP0004133_heterotaxia | 0.83699378 |
| 101 | MP0003890_abnormal_embryonic-extraembry | 0.82091790 |
| 102 | MP0004885_abnormal_endolymph | 0.81619840 |
| 103 | MP0002090_abnormal_vision | 0.80231646 |
| 104 | MP0003787_abnormal_imprinting | 0.77470349 |
| 105 | MP0001485_abnormal_pinna_reflex | 0.76887103 |
| 106 | MP0003329_amyloid_beta_deposits | 0.75976308 |
| 107 | MP0005646_abnormal_pituitary_gland | 0.75495288 |
| 108 | MP0000266_abnormal_heart_morphology | 0.75197114 |
| 109 | MP0000955_abnormal_spinal_cord | 0.75179276 |
| 110 | MP0003567_abnormal_fetal_cardiomyocyte | 0.73016031 |
| 111 | MP0002160_abnormal_reproductive_system | 0.71484579 |
| 112 | MP0002229_neurodegeneration | 0.71308658 |
| 113 | MP0005187_abnormal_penis_morphology | 0.71024385 |
| 114 | MP0004142_abnormal_muscle_tone | 0.70934507 |
| 115 | MP0000230_abnormal_systemic_arterial | 0.70672557 |
| 116 | MP0009780_abnormal_chondrocyte_physiolo | 0.68850097 |
| 117 | MP0005253_abnormal_eye_physiology | 0.68669376 |
| 118 | MP0005623_abnormal_meninges_morphology | 0.66384894 |
| 119 | MP0002752_abnormal_somatic_nervous | 0.62630470 |
| 120 | MP0002152_abnormal_brain_morphology | 0.61459926 |
| 121 | MP0004043_abnormal_pH_regulation | 0.61169209 |
| 122 | MP0001905_abnormal_dopamine_level | 0.59755121 |
| 123 | MP0003633_abnormal_nervous_system | 0.58205988 |
| 124 | MP0005535_abnormal_body_temperature | 0.57021629 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Sudden death (HP:0001699) | 7.16250992 |
| 2 | Atrial fibrillation (HP:0005110) | 5.97336687 |
| 3 | Primary atrial arrhythmia (HP:0001692) | 5.69769128 |
| 4 | Supraventricular tachycardia (HP:0004755) | 5.45755809 |
| 5 | Supraventricular arrhythmia (HP:0005115) | 5.31929086 |
| 6 | Ventricular tachycardia (HP:0004756) | 5.22453858 |
| 7 | Syncope (HP:0001279) | 5.22103428 |
| 8 | Prolonged QT interval (HP:0001657) | 4.93992189 |
| 9 | Calf muscle hypertrophy (HP:0008981) | 4.78455613 |
| 10 | Ventricular fibrillation (HP:0001663) | 4.60956673 |
| 11 | Exercise-induced myalgia (HP:0003738) | 4.38483150 |
| 12 | Muscle hypertrophy of the lower extremities (HP:0008968) | 4.32636080 |
| 13 | Bundle branch block (HP:0011710) | 4.32303423 |
| 14 | Abnormality of the calf musculature (HP:0001430) | 4.30741377 |
| 15 | Lipoatrophy (HP:0100578) | 4.05768852 |
| 16 | Hypoglycemic coma (HP:0001325) | 4.02947685 |
| 17 | Subaortic stenosis (HP:0001682) | 3.98859472 |
| 18 | Abnormality of the left ventricular outflow tract (HP:0011103) | 3.98859472 |
| 19 | Exercise-induced muscle cramps (HP:0003710) | 3.95103687 |
| 20 | Ventricular arrhythmia (HP:0004308) | 3.93832416 |
| 21 | Focal motor seizures (HP:0011153) | 3.90987100 |
| 22 | Abnormal EKG (HP:0003115) | 3.90694650 |
| 23 | Hypoglycemic seizures (HP:0002173) | 3.80351138 |
| 24 | Palpitations (HP:0001962) | 3.69447631 |
| 25 | Hyperinsulinemic hypoglycemia (HP:0000825) | 3.64139819 |
| 26 | Right ventricular cardiomyopathy (HP:0011663) | 3.58379857 |
| 27 | Muscle fiber splitting (HP:0003555) | 3.49975931 |
| 28 | Central scotoma (HP:0000603) | 3.33235988 |
| 29 | Left ventricular hypertrophy (HP:0001712) | 3.31042265 |
| 30 | Heart block (HP:0012722) | 3.27960676 |
| 31 | Dilated cardiomyopathy (HP:0001644) | 3.26691530 |
| 32 | Myokymia (HP:0002411) | 3.20133786 |
| 33 | Myoglobinuria (HP:0002913) | 3.05958048 |
| 34 | Hyporeflexia of lower limbs (HP:0002600) | 3.05430878 |
| 35 | Atrioventricular block (HP:0001678) | 3.03932781 |
| 36 | Focal seizures (HP:0007359) | 3.02069631 |
| 37 | Visual hallucinations (HP:0002367) | 3.00139401 |
| 38 | Abnormal atrioventricular conduction (HP:0005150) | 2.99690792 |
| 39 | Dysmetric saccades (HP:0000641) | 2.97880541 |
| 40 | Asymmetric septal hypertrophy (HP:0001670) | 2.91085142 |
| 41 | EMG: myopathic abnormalities (HP:0003458) | 2.91068967 |
| 42 | Myotonia (HP:0002486) | 2.89844293 |
| 43 | Pheochromocytoma (HP:0002666) | 2.89809494 |
| 44 | Epileptiform EEG discharges (HP:0011182) | 2.86445592 |
| 45 | Hyperglycemia (HP:0003074) | 2.84672961 |
| 46 | EEG with generalized epileptiform discharges (HP:0011198) | 2.79621791 |
| 47 | Hypothermia (HP:0002045) | 2.73839307 |
| 48 | Epileptic encephalopathy (HP:0200134) | 2.72676646 |
| 49 | Febrile seizures (HP:0002373) | 2.70105455 |
| 50 | Hypsarrhythmia (HP:0002521) | 2.66358339 |
| 51 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.63584067 |
| 52 | Acute necrotizing encephalopathy (HP:0006965) | 2.62497583 |
| 53 | Late onset (HP:0003584) | 2.61250658 |
| 54 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 2.57210173 |
| 55 | Large for gestational age (HP:0001520) | 2.53977039 |
| 56 | Progressive cerebellar ataxia (HP:0002073) | 2.53746641 |
| 57 | Neuroendocrine neoplasm (HP:0100634) | 2.49727392 |
| 58 | Insulin-resistant diabetes mellitus (HP:0000831) | 2.46984253 |
| 59 | Absence seizures (HP:0002121) | 2.41262139 |
| 60 | Congenital stationary night blindness (HP:0007642) | 2.41137159 |
| 61 | Limb dystonia (HP:0002451) | 2.38864318 |
| 62 | Proximal tubulopathy (HP:0000114) | 2.34660001 |
| 63 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.32760128 |
| 64 | Abnormality of alanine metabolism (HP:0010916) | 2.32760128 |
| 65 | Hyperalaninemia (HP:0003348) | 2.32760128 |
| 66 | Progressive macrocephaly (HP:0004481) | 2.30935176 |
| 67 | Ketosis (HP:0001946) | 2.30623870 |
| 68 | Increased circulating renin level (HP:0000848) | 2.29108803 |
| 69 | Hemiparesis (HP:0001269) | 2.26080650 |
| 70 | Atonic seizures (HP:0010819) | 2.25898011 |
| 71 | Dysdiadochokinesis (HP:0002075) | 2.24382488 |
| 72 | Glycosuria (HP:0003076) | 2.22557206 |
| 73 | Abnormality of urine glucose concentration (HP:0011016) | 2.22557206 |
| 74 | Difficulty running (HP:0009046) | 2.21529765 |
| 75 | Abnormal pancreas size (HP:0012094) | 2.19072330 |
| 76 | Broad-based gait (HP:0002136) | 2.18906773 |
| 77 | Abnormality of the pancreatic islet cells (HP:0006476) | 2.16659858 |
| 78 | Abnormality of endocrine pancreas physiology (HP:0012093) | 2.16659858 |
| 79 | Scotoma (HP:0000575) | 2.15531964 |
| 80 | Mitochondrial inheritance (HP:0001427) | 2.15285597 |
| 81 | Dialeptic seizures (HP:0011146) | 2.14947800 |
| 82 | Generalized tonic-clonic seizures (HP:0002069) | 2.13881116 |
| 83 | Drooling (HP:0002307) | 2.12088816 |
| 84 | Congenital malformation of the right heart (HP:0011723) | 2.11367451 |
| 85 | Double outlet right ventricle (HP:0001719) | 2.11367451 |
| 86 | Hepatocellular necrosis (HP:0001404) | 2.09708724 |
| 87 | Hepatic necrosis (HP:0002605) | 2.04834047 |
| 88 | Symptomatic seizures (HP:0011145) | 2.02955046 |
| 89 | Poor eye contact (HP:0000817) | 2.01659205 |
| 90 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 2.00591698 |
| 91 | Acute encephalopathy (HP:0006846) | 1.98079267 |
| 92 | Athetosis (HP:0002305) | 1.96883962 |
| 93 | Palmoplantar keratoderma (HP:0000982) | 1.96443554 |
| 94 | Tinnitus (HP:0000360) | 1.96252816 |
| 95 | Hamartoma of the eye (HP:0010568) | 1.96140069 |
| 96 | Gaze-evoked nystagmus (HP:0000640) | 1.95804415 |
| 97 | Abnormal social behavior (HP:0012433) | 1.95687875 |
| 98 | Impaired social interactions (HP:0000735) | 1.95687875 |
| 99 | Osteomalacia (HP:0002749) | 1.94280758 |
| 100 | Rhabdomyolysis (HP:0003201) | 1.93815863 |
| 101 | Increased CSF lactate (HP:0002490) | 1.93115972 |
| 102 | Action tremor (HP:0002345) | 1.93032130 |
| 103 | Hypomagnesemia (HP:0002917) | 1.91860316 |
| 104 | Genetic anticipation (HP:0003743) | 1.90323470 |
| 105 | Bradycardia (HP:0001662) | 1.90269594 |
| 106 | Hyperventilation (HP:0002883) | 1.89067485 |
| 107 | Ketoacidosis (HP:0001993) | 1.88399139 |
| 108 | Hyperphosphaturia (HP:0003109) | 1.88192709 |
| 109 | Excessive salivation (HP:0003781) | 1.87874754 |
| 110 | Generalized myoclonic seizures (HP:0002123) | 1.87431308 |
| 111 | Ragged-red muscle fibers (HP:0003200) | 1.84885102 |
| 112 | Anxiety (HP:0000739) | 1.84110134 |
| 113 | Depression (HP:0000716) | 1.80850515 |
| 114 | Tachypnea (HP:0002789) | 1.79984568 |
| 115 | EMG: neuropathic changes (HP:0003445) | 1.78900122 |
| 116 | Testicular neoplasm (HP:0010788) | 1.77993491 |
| 117 | Limb-girdle muscle atrophy (HP:0003797) | 1.77324303 |
| 118 | Increased connective tissue (HP:0009025) | 1.77233386 |
| 119 | Enlarged penis (HP:0000040) | 1.76240192 |
| 120 | Increased intramyocellular lipid droplets (HP:0012240) | 1.75876016 |
| 121 | Difficulty climbing stairs (HP:0003551) | 1.75458613 |
| 122 | Polyuria (HP:0000103) | 1.75062954 |
| 123 | Optic disc pallor (HP:0000543) | 1.74587307 |
| 124 | Lymphangioma (HP:0100764) | 1.74364003 |
| 125 | Increased muscle lipid content (HP:0009058) | 1.73132498 |
| 126 | Sudden cardiac death (HP:0001645) | 1.73115170 |
| 127 | Neoplasm of the adrenal gland (HP:0100631) | 1.71806780 |
| 128 | Abnormality of the foot musculature (HP:0001436) | 1.71601754 |
| 129 | Abnormal drinking behavior (HP:0030082) | 1.71397827 |
| 130 | Polydipsia (HP:0001959) | 1.71397827 |
| 131 | Prominent metopic ridge (HP:0005487) | 1.67524980 |
| 132 | Exercise intolerance (HP:0003546) | 1.67235522 |
| 133 | Dysmetria (HP:0001310) | 1.67020164 |
| 134 | Amblyopia (HP:0000646) | 1.66916716 |
| 135 | Abnormality of macular pigmentation (HP:0008002) | 1.64714585 |
| 136 | Agitation (HP:0000713) | 1.64281988 |
| 137 | Muscular hypotonia of the trunk (HP:0008936) | 1.64281040 |
| 138 | Polyphagia (HP:0002591) | 1.63755820 |
| 139 | Lactic acidosis (HP:0003128) | 1.63711578 |
| 140 | Metaphyseal dysplasia (HP:0100255) | 1.63440500 |
| 141 | Truncal ataxia (HP:0002078) | 1.61597408 |
| 142 | Disproportionate short-trunk short stature (HP:0003521) | 1.61107800 |
| 143 | Unsteady gait (HP:0002317) | 1.60490535 |
| 144 | Hypoplastic left heart (HP:0004383) | 1.60095006 |
| 145 | Increased variability in muscle fiber diameter (HP:0003557) | 1.59696016 |
| 146 | Abnormality of glycolysis (HP:0004366) | 1.59366013 |
| 147 | Increased serum pyruvate (HP:0003542) | 1.59366013 |
| 148 | Tongue fasciculations (HP:0001308) | 1.58981409 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FRK | 4.19998203 |
| 2 | PHKG2 | 3.39205177 |
| 3 | PHKG1 | 3.39205177 |
| 4 | MARK1 | 2.79880317 |
| 5 | MYLK | 2.78158401 |
| 6 | LMTK2 | 2.74425267 |
| 7 | MAP3K4 | 2.54852125 |
| 8 | TTN | 2.53894985 |
| 9 | NTRK3 | 2.41950513 |
| 10 | EPHA4 | 2.34184491 |
| 11 | DMPK | 2.33681553 |
| 12 | NEK1 | 2.30398298 |
| 13 | MAP3K9 | 2.24804918 |
| 14 | PAK6 | 2.16482167 |
| 15 | STK39 | 2.14300632 |
| 16 | PDK3 | 2.11516623 |
| 17 | PDK4 | 2.11516623 |
| 18 | FGFR2 | 2.08970503 |
| 19 | OBSCN | 2.08828261 |
| 20 | MAP2K7 | 1.79819874 |
| 21 | PINK1 | 1.79406312 |
| 22 | MINK1 | 1.75898062 |
| 23 | MUSK | 1.75802818 |
| 24 | PAK3 | 1.69655648 |
| 25 | OXSR1 | 1.68116541 |
| 26 | PKN2 | 1.66669583 |
| 27 | STK38 | 1.66132075 |
| 28 | STK24 | 1.55082093 |
| 29 | CAMK2D | 1.44670179 |
| 30 | MAP2K4 | 1.44260527 |
| 31 | BMPR1B | 1.42584468 |
| 32 | GRK7 | 1.41844238 |
| 33 | CSNK1G2 | 1.27905158 |
| 34 | CDC42BPA | 1.27834539 |
| 35 | DAPK2 | 1.27512296 |
| 36 | KSR1 | 1.25974322 |
| 37 | CAMK1 | 1.24625657 |
| 38 | CAMK2A | 1.24524079 |
| 39 | PIK3CA | 1.24422820 |
| 40 | TRIM28 | 1.23978202 |
| 41 | STK38L | 1.21263486 |
| 42 | CASK | 1.20444849 |
| 43 | PRPF4B | 1.17344254 |
| 44 | PDK2 | 1.16481817 |
| 45 | KSR2 | 1.14284994 |
| 46 | CSNK1G1 | 1.13312708 |
| 47 | INSRR | 1.12669063 |
| 48 | PRKD3 | 1.11819931 |
| 49 | LATS2 | 1.11050952 |
| 50 | NTRK2 | 1.10954465 |
| 51 | MAPK13 | 1.09960486 |
| 52 | CSNK1G3 | 1.05661668 |
| 53 | ACVR1B | 1.05267449 |
| 54 | CAMK4 | 0.99968319 |
| 55 | PASK | 0.98686075 |
| 56 | RIPK1 | 0.98417111 |
| 57 | CAMKK1 | 0.97221623 |
| 58 | PRKAA1 | 0.95066199 |
| 59 | MAP3K6 | 0.93971199 |
| 60 | UHMK1 | 0.93881754 |
| 61 | CDK5 | 0.91819785 |
| 62 | GRK5 | 0.88229749 |
| 63 | SGK2 | 0.86697802 |
| 64 | ROCK1 | 0.85825607 |
| 65 | ADRBK2 | 0.85217322 |
| 66 | PLK2 | 0.84375622 |
| 67 | LIMK1 | 0.84090969 |
| 68 | SGK494 | 0.83433138 |
| 69 | SGK223 | 0.83433138 |
| 70 | PRKD1 | 0.82551955 |
| 71 | STK3 | 0.82007432 |
| 72 | MAPK12 | 0.80770111 |
| 73 | DAPK3 | 0.78933316 |
| 74 | PRKCE | 0.78877029 |
| 75 | CSNK1A1L | 0.78017947 |
| 76 | NLK | 0.76815915 |
| 77 | GRK1 | 0.76679379 |
| 78 | ROCK2 | 0.76517613 |
| 79 | TIE1 | 0.74274548 |
| 80 | MAP3K7 | 0.72761090 |
| 81 | BCR | 0.71766929 |
| 82 | PTK2B | 0.70844928 |
| 83 | MAP3K12 | 0.69335851 |
| 84 | TRPM7 | 0.68974331 |
| 85 | MAP3K5 | 0.68838406 |
| 86 | NTRK1 | 0.68505386 |
| 87 | PNCK | 0.67297957 |
| 88 | WNK3 | 0.66040544 |
| 89 | PKN1 | 0.65517769 |
| 90 | SGK3 | 0.65313835 |
| 91 | WNK1 | 0.64826711 |
| 92 | PRKCH | 0.64260874 |
| 93 | RET | 0.64163749 |
| 94 | PRKCG | 0.63382846 |
| 95 | DYRK1A | 0.62501405 |
| 96 | CAMKK2 | 0.62457033 |
| 97 | ILK | 0.62111668 |
| 98 | MARK2 | 0.60884301 |
| 99 | DAPK1 | 0.57240309 |
| 100 | ERBB3 | 0.56144212 |
| 101 | STK11 | 0.56077765 |
| 102 | PRKACA | 0.55990591 |
| 103 | SGK1 | 0.54548147 |
| 104 | PRKACB | 0.52762574 |
| 105 | NME1 | 0.52707110 |
| 106 | CAMK2G | 0.52257634 |
| 107 | AKT3 | 0.52182990 |
| 108 | FER | 0.51896029 |
| 109 | DYRK2 | 0.50963836 |
| 110 | WNK4 | 0.50527019 |
| 111 | CAMK2B | 0.49637698 |
| 112 | BCKDK | 0.48456488 |
| 113 | TRIB3 | 0.46418267 |
| 114 | RPS6KA3 | 0.45163889 |
| 115 | BMPR2 | 0.45044101 |
| 116 | PRKCZ | 0.45029622 |
| 117 | MST4 | 0.44854588 |
| 118 | MAP2K6 | 0.44538206 |
| 119 | MAP4K2 | 0.44377444 |
| 120 | SIK2 | 0.44015296 |
| 121 | TNIK | 0.43303542 |
| 122 | PRKG1 | 0.42059099 |
| 123 | MAP2K1 | 0.41040963 |
| 124 | HIPK2 | 0.39354785 |
| 125 | CDK18 | 0.39298842 |
| 126 | ADRBK1 | 0.39129489 |
| 127 | PDK1 | 0.39012248 |
| 128 | PRKACG | 0.39009007 |
| 129 | PRKAA2 | 0.38906466 |
| 130 | PRKCA | 0.38787180 |
| 131 | CAMK1G | 0.38498218 |
| 132 | MKNK2 | 0.38056707 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 3.63600437 |
| 2 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 3.59069579 |
| 3 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 2.91405378 |
| 4 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 2.86495304 |
| 5 | Nicotine addiction_Homo sapiens_hsa05033 | 2.78200856 |
| 6 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 2.60677807 |
| 7 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.45835846 |
| 8 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 2.26458759 |
| 9 | Circadian entrainment_Homo sapiens_hsa04713 | 2.19237548 |
| 10 | Parkinsons disease_Homo sapiens_hsa05012 | 2.15144111 |
| 11 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.14817978 |
| 12 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.14675769 |
| 13 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.10606776 |
| 14 | GABAergic synapse_Homo sapiens_hsa04727 | 2.07143569 |
| 15 | Olfactory transduction_Homo sapiens_hsa04740 | 1.99343460 |
| 16 | Morphine addiction_Homo sapiens_hsa05032 | 1.96548462 |
| 17 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.93352231 |
| 18 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.91979169 |
| 19 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.89708617 |
| 20 | Alzheimers disease_Homo sapiens_hsa05010 | 1.80201068 |
| 21 | Insulin secretion_Homo sapiens_hsa04911 | 1.72081846 |
| 22 | Long-term potentiation_Homo sapiens_hsa04720 | 1.69229867 |
| 23 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.59174876 |
| 24 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.58625380 |
| 25 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.55599022 |
| 26 | Taste transduction_Homo sapiens_hsa04742 | 1.54468176 |
| 27 | Salivary secretion_Homo sapiens_hsa04970 | 1.52842884 |
| 28 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.51096670 |
| 29 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.50790191 |
| 30 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.50133825 |
| 31 | Huntingtons disease_Homo sapiens_hsa05016 | 1.47483499 |
| 32 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.46274707 |
| 33 | Renin secretion_Homo sapiens_hsa04924 | 1.45303424 |
| 34 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.38375631 |
| 35 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.30442621 |
| 36 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.27120884 |
| 37 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.22990933 |
| 38 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.20746261 |
| 39 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.19844882 |
| 40 | Gap junction_Homo sapiens_hsa04540 | 1.12421362 |
| 41 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.10995131 |
| 42 | Circadian rhythm_Homo sapiens_hsa04710 | 1.07672617 |
| 43 | Carbon metabolism_Homo sapiens_hsa01200 | 1.07296826 |
| 44 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.06650942 |
| 45 | Long-term depression_Homo sapiens_hsa04730 | 1.04535147 |
| 46 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.04237068 |
| 47 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.02397767 |
| 48 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.98231319 |
| 49 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.93476533 |
| 50 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.92684588 |
| 51 | Cocaine addiction_Homo sapiens_hsa05030 | 0.90128481 |
| 52 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.88959182 |
| 53 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.88670649 |
| 54 | Phototransduction_Homo sapiens_hsa04744 | 0.85431033 |
| 55 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.82418751 |
| 56 | Bile secretion_Homo sapiens_hsa04976 | 0.81914010 |
| 57 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.80153212 |
| 58 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.79806290 |
| 59 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.79033145 |
| 60 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.77696592 |
| 61 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.76792419 |
| 62 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.73189654 |
| 63 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.72925151 |
| 64 | Axon guidance_Homo sapiens_hsa04360 | 0.72262818 |
| 65 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.71279561 |
| 66 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.71059329 |
| 67 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.69997365 |
| 68 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.69676427 |
| 69 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.68616061 |
| 70 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.67007753 |
| 71 | Viral myocarditis_Homo sapiens_hsa05416 | 0.65771249 |
| 72 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.65540898 |
| 73 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.64079472 |
| 74 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.63614944 |
| 75 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.61463906 |
| 76 | Melanogenesis_Homo sapiens_hsa04916 | 0.58372547 |
| 77 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.56887612 |
| 78 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.56847192 |
| 79 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.55950665 |
| 80 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.55711803 |
| 81 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.55453863 |
| 82 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.55186759 |
| 83 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.54499499 |
| 84 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.54110314 |
| 85 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.53938139 |
| 86 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.53710735 |
| 87 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.53668491 |
| 88 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.53470477 |
| 89 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.51619628 |
| 90 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.51209581 |
| 91 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.50941164 |
| 92 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.50016734 |
| 93 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.49352143 |
| 94 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.48306785 |
| 95 | Glioma_Homo sapiens_hsa05214 | 0.47410915 |
| 96 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.46650693 |
| 97 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.46295161 |
| 98 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.45907883 |
| 99 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.45221022 |
| 100 | Mineral absorption_Homo sapiens_hsa04978 | 0.44847840 |
| 101 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.44754641 |
| 102 | ABC transporters_Homo sapiens_hsa02010 | 0.44184303 |
| 103 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.43861566 |
| 104 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.42630828 |
| 105 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.41112040 |
| 106 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.40494782 |
| 107 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.40478686 |
| 108 | Tight junction_Homo sapiens_hsa04530 | 0.40306666 |
| 109 | Insulin resistance_Homo sapiens_hsa04931 | 0.40272934 |
| 110 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.39743079 |
| 111 | Endometrial cancer_Homo sapiens_hsa05213 | 0.36352391 |
| 112 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.34420214 |
| 113 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.33845026 |
| 114 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.33751803 |
| 115 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.33247060 |
| 116 | Peroxisome_Homo sapiens_hsa04146 | 0.31633551 |
| 117 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.31527313 |
| 118 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.31250211 |
| 119 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.30458923 |
| 120 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.28877149 |
| 121 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.28698423 |
| 122 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.28136566 |
| 123 | Focal adhesion_Homo sapiens_hsa04510 | 0.27370545 |
| 124 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.25770607 |

