

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 4.92105219 |
| 2 | rRNA modification (GO:0000154) | 4.62751346 |
| 3 | maturation of SSU-rRNA (GO:0030490) | 4.52381644 |
| 4 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.49188016 |
| 5 | formation of translation preinitiation complex (GO:0001731) | 4.29731099 |
| 6 | DNA strand elongation (GO:0022616) | 4.28284681 |
| 7 | nucleobase biosynthetic process (GO:0046112) | 4.25812408 |
| 8 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.25406097 |
| 9 | purine nucleobase biosynthetic process (GO:0009113) | 4.16903125 |
| 10 | proteasome assembly (GO:0043248) | 4.09745036 |
| 11 | DNA replication initiation (GO:0006270) | 4.05464528 |
| 12 | ribosomal large subunit biogenesis (GO:0042273) | 3.96545891 |
| 13 | rRNA methylation (GO:0031167) | 3.96470905 |
| 14 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.96455192 |
| 15 | ribosomal small subunit assembly (GO:0000028) | 3.93571190 |
| 16 | protein maturation by protein folding (GO:0022417) | 3.86627972 |
| 17 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.86433214 |
| 18 | DNA replication checkpoint (GO:0000076) | 3.85724273 |
| 19 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.81234645 |
| 20 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.81039070 |
| 21 | GDP-mannose metabolic process (GO:0019673) | 3.78928263 |
| 22 | chaperone-mediated protein transport (GO:0072321) | 3.75366378 |
| 23 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.74785632 |
| 24 | pentose metabolic process (GO:0019321) | 3.74171638 |
| 25 | ribosomal small subunit biogenesis (GO:0042274) | 3.73885157 |
| 26 | negative regulation of ligase activity (GO:0051352) | 3.71853740 |
| 27 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.71853740 |
| 28 | viral transcription (GO:0019083) | 3.68648180 |
| 29 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.66512652 |
| 30 | chromatin remodeling at centromere (GO:0031055) | 3.66470930 |
| 31 | translational termination (GO:0006415) | 3.64696528 |
| 32 | spliceosomal snRNP assembly (GO:0000387) | 3.63991925 |
| 33 | DNA unwinding involved in DNA replication (GO:0006268) | 3.62199256 |
| 34 | telomere maintenance via recombination (GO:0000722) | 3.62186120 |
| 35 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.61305577 |
| 36 | CENP-A containing nucleosome assembly (GO:0034080) | 3.61133894 |
| 37 | ribosome biogenesis (GO:0042254) | 3.59542990 |
| 38 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 3.59358473 |
| 39 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.55770523 |
| 40 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.50420888 |
| 41 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.50420888 |
| 42 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.49714070 |
| 43 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.49714070 |
| 44 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.48071879 |
| 45 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.48071879 |
| 46 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.48071879 |
| 47 | telomere maintenance via telomere lengthening (GO:0010833) | 3.46824525 |
| 48 | IMP biosynthetic process (GO:0006188) | 3.45117305 |
| 49 | translational elongation (GO:0006414) | 3.44762280 |
| 50 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.43242175 |
| 51 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.43242175 |
| 52 | pyrimidine-containing compound salvage (GO:0008655) | 3.42374905 |
| 53 | pyrimidine nucleoside salvage (GO:0043097) | 3.42374905 |
| 54 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.42220522 |
| 55 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.37522865 |
| 56 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.37043539 |
| 57 | establishment of integrated proviral latency (GO:0075713) | 3.36061820 |
| 58 | rRNA processing (GO:0006364) | 3.35832762 |
| 59 | regulation of mitochondrial translation (GO:0070129) | 3.35670713 |
| 60 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.34458244 |
| 61 | mitotic recombination (GO:0006312) | 3.32312101 |
| 62 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.32263260 |
| 63 | mitotic metaphase plate congression (GO:0007080) | 3.31674565 |
| 64 | translational initiation (GO:0006413) | 3.31552971 |
| 65 | pseudouridine synthesis (GO:0001522) | 3.27814865 |
| 66 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.24089937 |
| 67 | folic acid metabolic process (GO:0046655) | 3.24029917 |
| 68 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.23755047 |
| 69 | rRNA metabolic process (GO:0016072) | 3.23503683 |
| 70 | DNA replication-independent nucleosome organization (GO:0034724) | 3.22757037 |
| 71 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.22757037 |
| 72 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.22645009 |
| 73 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.21525521 |
| 74 | positive regulation of ligase activity (GO:0051351) | 3.21229787 |
| 75 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.19791621 |
| 76 | ribosome assembly (GO:0042255) | 3.18621550 |
| 77 | histone exchange (GO:0043486) | 3.17666219 |
| 78 | translation (GO:0006412) | 3.17533212 |
| 79 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.17274930 |
| 80 | nucleoside salvage (GO:0043174) | 3.16930637 |
| 81 | 7-methylguanosine mRNA capping (GO:0006370) | 3.14665047 |
| 82 | cullin deneddylation (GO:0010388) | 3.13628872 |
| 83 | cotranslational protein targeting to membrane (GO:0006613) | 3.11783994 |
| 84 | protein targeting to ER (GO:0045047) | 3.09669172 |
| 85 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.09536609 |
| 86 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.08249825 |
| 87 | 7-methylguanosine RNA capping (GO:0009452) | 3.08070589 |
| 88 | RNA capping (GO:0036260) | 3.08070589 |
| 89 | pentose-phosphate shunt (GO:0006098) | 3.07526880 |
| 90 | IMP metabolic process (GO:0046040) | 3.07141033 |
| 91 | cellular component biogenesis (GO:0044085) | 3.07005307 |
| 92 | binding of sperm to zona pellucida (GO:0007339) | 3.06865645 |
| 93 | glycine metabolic process (GO:0006544) | 3.03949254 |
| 94 | termination of RNA polymerase III transcription (GO:0006386) | 3.03778363 |
| 95 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.03778363 |
| 96 | cell cycle G1/S phase transition (GO:0044843) | 3.02696890 |
| 97 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.02696890 |
| 98 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.02577136 |
| 99 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.02248333 |
| 100 | protein localization to kinetochore (GO:0034501) | 3.00710802 |
| 101 | regulation of ligase activity (GO:0051340) | 2.99480449 |
| 102 | peptidyl-histidine modification (GO:0018202) | 2.99196396 |
| 103 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.98404311 |
| 104 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.96917388 |
| 105 | * protein targeting to mitochondrion (GO:0006626) | 2.96153102 |
| 106 | protein localization to endoplasmic reticulum (GO:0070972) | 2.95093312 |
| 107 | regulation of superoxide anion generation (GO:0032928) | 2.94827492 |
| 108 | viral life cycle (GO:0019058) | 2.93276216 |
| 109 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.93203270 |
| 110 | cellular protein complex disassembly (GO:0043624) | 2.92530947 |
| 111 | response to peptidoglycan (GO:0032494) | 2.91687653 |
| 112 | protein deneddylation (GO:0000338) | 2.91262298 |
| 113 | UTP biosynthetic process (GO:0006228) | 2.91178365 |
| 114 | L-methionine salvage (GO:0071267) | 2.90886863 |
| 115 | L-methionine biosynthetic process (GO:0071265) | 2.90886863 |
| 116 | amino acid salvage (GO:0043102) | 2.90886863 |
| 117 | mitotic nuclear envelope disassembly (GO:0007077) | 2.90014041 |
| 118 | spliceosomal complex assembly (GO:0000245) | 2.89744683 |
| 119 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.89607322 |
| 120 | GTP biosynthetic process (GO:0006183) | 2.87016454 |
| 121 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.86144215 |
| 122 | nucleotide salvage (GO:0043173) | 2.84034909 |
| 123 | NADPH regeneration (GO:0006740) | 2.82426856 |
| 124 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.81306296 |
| 125 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.81306296 |
| 126 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 2.76749021 |
| 127 | NIK/NF-kappaB signaling (GO:0038061) | 2.74678251 |
| 128 | CTP biosynthetic process (GO:0006241) | 2.72962416 |
| 129 | CTP metabolic process (GO:0046036) | 2.72962416 |
| 130 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.72383507 |
| 131 | ATP synthesis coupled proton transport (GO:0015986) | 2.72383507 |
| 132 | base-excision repair, AP site formation (GO:0006285) | 2.67460990 |
| 133 | UV protection (GO:0009650) | 2.65886120 |
| 134 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.65786713 |
| 135 | * establishment of protein localization to mitochondrion (GO:0072655) | 2.64701163 |
| 136 | pyrimidine nucleotide catabolic process (GO:0006244) | 2.58571280 |
| 137 | positive regulation of cell cycle arrest (GO:0071158) | 2.55697163 |
| 138 | iron-sulfur cluster assembly (GO:0016226) | 2.55336880 |
| 139 | metallo-sulfur cluster assembly (GO:0031163) | 2.55336880 |
| 140 | protein retention in ER lumen (GO:0006621) | 2.54168255 |
| 141 | establishment of viral latency (GO:0019043) | 2.52902441 |
| 142 | * protein localization to mitochondrion (GO:0070585) | 2.52504899 |
| 143 | pinocytosis (GO:0006907) | 2.52132955 |
| 144 | negative regulation of protein ubiquitination (GO:0031397) | 2.51375145 |
| 145 | Golgi transport vesicle coating (GO:0048200) | 2.49094838 |
| 146 | COPI coating of Golgi vesicle (GO:0048205) | 2.49094838 |
| 147 | negative regulation of protein modification by small protein conjugation or removal (GO:1903321) | 2.47409422 |
| 148 | nuclear envelope reassembly (GO:0031468) | 2.47187944 |
| 149 | mitotic nuclear envelope reassembly (GO:0007084) | 2.47187944 |
| 150 | deoxyribonucleotide catabolic process (GO:0009264) | 2.46646247 |
| 151 | amyloid precursor protein catabolic process (GO:0042987) | 2.46150824 |
| 152 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.46122755 |
| 153 | regulation of cellular amine metabolic process (GO:0033238) | 2.45544122 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.88361885 |
| 2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.21671664 |
| 3 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.95796368 |
| 4 | * KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.59578708 |
| 5 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.45294481 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.31274909 |
| 7 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.20401896 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.13779436 |
| 9 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.09948722 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.00326092 |
| 11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.94937651 |
| 12 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.86782724 |
| 13 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.85071364 |
| 14 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.83440199 |
| 15 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.80050898 |
| 16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.80018409 |
| 17 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.64054464 |
| 18 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.55881957 |
| 19 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.49004845 |
| 20 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.42990950 |
| 21 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.42094075 |
| 22 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.32315000 |
| 23 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.22172229 |
| 24 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.16064207 |
| 25 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.15750974 |
| 26 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.11525809 |
| 27 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.10704713 |
| 28 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.09205913 |
| 29 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.08630639 |
| 30 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.08031987 |
| 31 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.01231646 |
| 32 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.96814484 |
| 33 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.94502199 |
| 34 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.91036280 |
| 35 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.89418720 |
| 36 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.87246531 |
| 37 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.85981902 |
| 38 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.83670819 |
| 39 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.78832130 |
| 40 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.76056446 |
| 41 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.73178103 |
| 42 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.72981634 |
| 43 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.70786762 |
| 44 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.70295242 |
| 45 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.69914993 |
| 46 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.61362386 |
| 47 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.59315613 |
| 48 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.57760533 |
| 49 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.57356879 |
| 50 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.56988197 |
| 51 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.55352821 |
| 52 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.52722614 |
| 53 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.51908975 |
| 54 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.48798081 |
| 55 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.47830464 |
| 56 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.46887644 |
| 57 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.42363946 |
| 58 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.41817585 |
| 59 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.41161411 |
| 60 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.40255734 |
| 61 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.36962440 |
| 62 | P68_20966046_ChIP-Seq_HELA_Human | 1.36956376 |
| 63 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.35891132 |
| 64 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.35432959 |
| 65 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.34819735 |
| 66 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.33943453 |
| 67 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.33796161 |
| 68 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.33609633 |
| 69 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.31440086 |
| 70 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.30579306 |
| 71 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.29784646 |
| 72 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.26864920 |
| 73 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.26438147 |
| 74 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.26144966 |
| 75 | * MAF_26560356_Chip-Seq_TH2_Human | 1.22789959 |
| 76 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.21554962 |
| 77 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.20845349 |
| 78 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.20803449 |
| 79 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.20474779 |
| 80 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.18650747 |
| 81 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.18604251 |
| 82 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.17838052 |
| 83 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.15994743 |
| 84 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.14248811 |
| 85 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.12192853 |
| 86 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.11454648 |
| 87 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.11285593 |
| 88 | MAF_26560356_Chip-Seq_TH1_Human | 1.11245229 |
| 89 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.11052580 |
| 90 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.10665144 |
| 91 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.10174771 |
| 92 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.09133710 |
| 93 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.08060803 |
| 94 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.07409580 |
| 95 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.07257352 |
| 96 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.06579269 |
| 97 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.05725237 |
| 98 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.05462037 |
| 99 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.05361375 |
| 100 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.04989972 |
| 101 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.04841198 |
| 102 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.03993093 |
| 103 | UTX_26944678_Chip-Seq_JUKART_Human | 1.02047667 |
| 104 | CTCF_21964334_Chip-Seq_Bcells_Human | 1.01679567 |
| 105 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.01217311 |
| 106 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.00194354 |
| 107 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.00038180 |
| 108 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.99908854 |
| 109 | MYC_22102868_ChIP-Seq_BL_Human | 0.98757905 |
| 110 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.97701146 |
| 111 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.97437245 |
| 112 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.97344728 |
| 113 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.96595163 |
| 114 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.95864919 |
| 115 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.95520542 |
| 116 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.94926372 |
| 117 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.91573351 |
| 118 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.91141489 |
| 119 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.90201071 |
| 120 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.90061508 |
| 121 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.88860393 |
| 122 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.87567398 |
| 123 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.87499922 |
| 124 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.87327735 |
| 125 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.86460487 |
| 126 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.84292552 |
| 127 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.83968951 |
| 128 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.83779219 |
| 129 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.82684139 |
| 130 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.81949836 |
| 131 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.80091990 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.35663628 |
| 2 | MP0003806_abnormal_nucleotide_metabolis | 4.62883829 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 4.28564501 |
| 4 | MP0010094_abnormal_chromosome_stability | 4.01673697 |
| 5 | MP0003111_abnormal_nucleus_morphology | 3.92052795 |
| 6 | MP0005058_abnormal_lysosome_morphology | 3.70389395 |
| 7 | MP0003077_abnormal_cell_cycle | 3.59129266 |
| 8 | MP0008057_abnormal_DNA_replication | 3.17672281 |
| 9 | MP0008058_abnormal_DNA_repair | 3.00354729 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.84880669 |
| 11 | MP0008007_abnormal_cellular_replicative | 2.80542367 |
| 12 | MP0005410_abnormal_fertilization | 2.78059167 |
| 13 | MP0003191_abnormal_cellular_cholesterol | 2.76238011 |
| 14 | MP0008877_abnormal_DNA_methylation | 2.38339033 |
| 15 | MP0001730_embryonic_growth_arrest | 2.28634992 |
| 16 | MP0003436_decreased_susceptibility_to | 2.17715677 |
| 17 | MP0005360_urolithiasis | 2.03577409 |
| 18 | MP0003718_maternal_effect | 1.96530070 |
| 19 | MP0003172_abnormal_lysosome_physiology | 1.94559717 |
| 20 | MP0002132_abnormal_respiratory_system | 1.93982111 |
| 21 | MP0003186_abnormal_redox_activity | 1.93871531 |
| 22 | MP0000678_abnormal_parathyroid_gland | 1.88628011 |
| 23 | MP0003786_premature_aging | 1.87482687 |
| 24 | MP0004858_abnormal_nervous_system | 1.84031308 |
| 25 | MP0006036_abnormal_mitochondrial_physio | 1.82402357 |
| 26 | MP0000350_abnormal_cell_proliferation | 1.70858359 |
| 27 | MP0001929_abnormal_gametogenesis | 1.69335096 |
| 28 | MP0005085_abnormal_gallbladder_physiolo | 1.60864664 |
| 29 | MP0002396_abnormal_hematopoietic_system | 1.60460266 |
| 30 | MP0004133_heterotaxia | 1.58487671 |
| 31 | MP0002877_abnormal_melanocyte_morpholog | 1.58435859 |
| 32 | MP0002419_abnormal_innate_immunity | 1.58006366 |
| 33 | MP0001835_abnormal_antigen_presentation | 1.55557042 |
| 34 | MP0010352_gastrointestinal_tract_polyps | 1.54231096 |
| 35 | MP0009333_abnormal_splenocyte_physiolog | 1.54132402 |
| 36 | MP0003123_paternal_imprinting | 1.54004891 |
| 37 | MP0002160_abnormal_reproductive_system | 1.53020629 |
| 38 | MP0002139_abnormal_hepatobiliary_system | 1.51301752 |
| 39 | MP0004233_abnormal_muscle_weight | 1.51154229 |
| 40 | MP0002210_abnormal_sex_determination | 1.50123290 |
| 41 | MP0005025_abnormal_response_to | 1.47771199 |
| 42 | MP0009278_abnormal_bone_marrow | 1.46389138 |
| 43 | MP0001293_anophthalmia | 1.44771608 |
| 44 | MP0006292_abnormal_olfactory_placode | 1.43246097 |
| 45 | * MP0002080_prenatal_lethality | 1.41670775 |
| 46 | MP0000313_abnormal_cell_death | 1.41593560 |
| 47 | MP0009785_altered_susceptibility_to | 1.41302082 |
| 48 | MP0001849_ear_inflammation | 1.40912606 |
| 49 | MP0003656_abnormal_erythrocyte_physiolo | 1.39448877 |
| 50 | MP0001145_abnormal_male_reproductive | 1.39346005 |
| 51 | MP0001697_abnormal_embryo_size | 1.36929375 |
| 52 | MP0001764_abnormal_homeostasis | 1.35582898 |
| 53 | MP0006035_abnormal_mitochondrial_morpho | 1.34485621 |
| 54 | MP0008875_abnormal_xenobiotic_pharmacok | 1.34381452 |
| 55 | MP0001661_extended_life_span | 1.31664120 |
| 56 | MP0002148_abnormal_hypersensitivity_rea | 1.31166588 |
| 57 | MP0000490_abnormal_crypts_of | 1.30697616 |
| 58 | MP0010030_abnormal_orbit_morphology | 1.29090536 |
| 59 | MP0002019_abnormal_tumor_incidence | 1.28275926 |
| 60 | MP0003698_abnormal_male_reproductive | 1.28157048 |
| 61 | MP0001672_abnormal_embryogenesis/_devel | 1.26550053 |
| 62 | MP0005380_embryogenesis_phenotype | 1.26550053 |
| 63 | MP0003075_altered_response_to | 1.25204939 |
| 64 | MP0005266_abnormal_metabolism | 1.24818897 |
| 65 | MP0009840_abnormal_foam_cell | 1.22958589 |
| 66 | MP0000358_abnormal_cell_content/ | 1.20507843 |
| 67 | MP0005464_abnormal_platelet_physiology | 1.19870272 |
| 68 | MP0010307_abnormal_tumor_latency | 1.16797456 |
| 69 | MP0006082_CNS_inflammation | 1.16729312 |
| 70 | MP0005397_hematopoietic_system_phenotyp | 1.13839677 |
| 71 | MP0001545_abnormal_hematopoietic_system | 1.13839677 |
| 72 | MP0000653_abnormal_sex_gland | 1.12616775 |
| 73 | MP0000372_irregular_coat_pigmentation | 1.11657513 |
| 74 | MP0005075_abnormal_melanosome_morpholog | 1.11382096 |
| 75 | MP0002085_abnormal_embryonic_tissue | 1.11086471 |
| 76 | MP0002723_abnormal_immune_serum | 1.10626546 |
| 77 | MP0002420_abnormal_adaptive_immunity | 1.09980955 |
| 78 | MP0005501_abnormal_skin_physiology | 1.09578675 |
| 79 | MP0001819_abnormal_immune_cell | 1.09178978 |
| 80 | MP0005670_abnormal_white_adipose | 1.08957134 |
| 81 | MP0005083_abnormal_biliary_tract | 1.07655415 |
| 82 | MP0003984_embryonic_growth_retardation | 1.07363646 |
| 83 | MP0000681_abnormal_thyroid_gland | 1.07001847 |
| 84 | MP0000343_altered_response_to | 1.06810971 |
| 85 | MP0005000_abnormal_immune_tolerance | 1.06140864 |
| 86 | MP0002452_abnormal_antigen_presenting | 1.05274696 |
| 87 | MP0004381_abnormal_hair_follicle | 1.05023955 |
| 88 | MP0005389_reproductive_system_phenotype | 1.04061333 |
| 89 | MP0000685_abnormal_immune_system | 1.02602377 |
| 90 | MP0002088_abnormal_embryonic_growth/wei | 1.01968542 |
| 91 | MP0002796_impaired_skin_barrier | 1.01543716 |
| 92 | MP0003303_peritoneal_inflammation | 1.01158326 |
| 93 | MP0008469_abnormal_protein_level | 1.00910314 |
| 94 | MP0000015_abnormal_ear_pigmentation | 1.00530616 |
| 95 | MP0001845_abnormal_inflammatory_respons | 0.99441738 |
| 96 | MP0005332_abnormal_amino_acid | 0.97925705 |
| 97 | MP0002405_respiratory_system_inflammati | 0.97479414 |
| 98 | MP0003705_abnormal_hypodermis_morpholog | 0.95593669 |
| 99 | MP0002653_abnormal_ependyma_morphology | 0.95242322 |
| 100 | MP0003448_altered_tumor_morphology | 0.94294636 |
| 101 | MP0000716_abnormal_immune_system | 0.93116403 |
| 102 | MP0003453_abnormal_keratinocyte_physiol | 0.93039090 |
| 103 | MP0000689_abnormal_spleen_morphology | 0.91490240 |
| 104 | MP0004947_skin_inflammation | 0.91199451 |
| 105 | MP0002722_abnormal_immune_system | 0.90141737 |
| 106 | MP0001533_abnormal_skeleton_physiology | 0.89810367 |
| 107 | * MP0005319_abnormal_enzyme/_coenzyme | 0.88703289 |
| 108 | MP0001853_heart_inflammation | 0.88424978 |
| 109 | MP0005671_abnormal_response_to | 0.87913941 |
| 110 | MP0000598_abnormal_liver_morphology | 0.87685589 |
| 111 | MP0005365_abnormal_bile_salt | 0.87497003 |
| 112 | MP0002161_abnormal_fertility/fecundity | 0.87226915 |
| 113 | MP0001727_abnormal_embryo_implantation | 0.87132109 |
| 114 | MP0002086_abnormal_extraembryonic_tissu | 0.86314545 |
| 115 | MP0009697_abnormal_copulation | 0.85326230 |
| 116 | MP0004197_abnormal_fetal_growth/weight/ | 0.85236636 |
| 117 | MP0002163_abnormal_gland_morphology | 0.85039185 |
| 118 | MP0002084_abnormal_developmental_patter | 0.84815288 |
| 119 | MP0004019_abnormal_vitamin_homeostasis | 0.82610439 |
| 120 | MP0000703_abnormal_thymus_morphology | 0.81607034 |
| 121 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.80594632 |
| 122 | MP0003221_abnormal_cardiomyocyte_apopto | 0.80304307 |
| 123 | MP0008004_abnormal_stomach_pH | 0.80044551 |
| 124 | MP0005408_hypopigmentation | 0.79462610 |
| 125 | MP0001790_abnormal_immune_system | 0.77646337 |
| 126 | MP0005387_immune_system_phenotype | 0.77646337 |
| 127 | MP0002398_abnormal_bone_marrow | 0.75762516 |
| 128 | MP0001800_abnormal_humoral_immune | 0.75716409 |
| 129 | MP0003763_abnormal_thymus_physiology | 0.75017360 |
| 130 | MP0000750_abnormal_muscle_regeneration | 0.74305433 |
| 131 | MP0009672_abnormal_birth_weight | 0.74089809 |
| 132 | MP0003566_abnormal_cell_adhesion | 0.73114605 |
| 133 | MP0004185_abnormal_adipocyte_glucose | 0.72750258 |
| 134 | MP0005377_hearing/vestibular/ear_phenot | 0.72724613 |
| 135 | MP0003878_abnormal_ear_physiology | 0.72724613 |
| 136 | MP0002429_abnormal_blood_cell | 0.72557176 |
| 137 | MP0005376_homeostasis/metabolism_phenot | 0.70955259 |
| 138 | MP0000858_altered_metastatic_potential | 0.70659052 |
| 139 | MP0004147_increased_porphyrin_level | 0.69010644 |
| 140 | MP0003315_abnormal_perineum_morphology | 0.68554731 |
| 141 | MP0004808_abnormal_hematopoietic_stem | 0.67205698 |
| 142 | MP0003119_abnormal_digestive_system | 0.65769818 |
| 143 | MP0008260_abnormal_autophagy | 0.65359817 |
| 144 | MP0000609_abnormal_liver_physiology | 0.63333916 |
| 145 | MP0002282_abnormal_trachea_morphology | 0.63068167 |
| 146 | MP0002111_abnormal_tail_morphology | 0.62416728 |
| 147 | MP0005384_cellular_phenotype | 0.62116896 |
| 148 | MP0003567_abnormal_fetal_cardiomyocyte | 0.61654795 |
| 149 | MP0009643_abnormal_urine_homeostasis | 0.61495010 |
| 150 | MP0005451_abnormal_body_composition | 0.60586110 |
| 151 | MP0005636_abnormal_mineral_homeostasis | 0.60210911 |
| 152 | MP0002092_abnormal_eye_morphology | 0.59086910 |
| 153 | MP0003011_delayed_dark_adaptation | 0.58433110 |
| 154 | MP0000477_abnormal_intestine_morphology | 0.58022592 |
| 155 | MP0009379_abnormal_foot_pigmentation | 0.57881600 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 4.50714103 |
| 2 | Reticulocytopenia (HP:0001896) | 4.30709099 |
| 3 | Oral leukoplakia (HP:0002745) | 4.17134720 |
| 4 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.12080884 |
| 5 | Abnormal number of erythroid precursors (HP:0012131) | 3.99944865 |
| 6 | Vertebral compression fractures (HP:0002953) | 3.58830279 |
| 7 | Cerebral hypomyelination (HP:0006808) | 3.56585045 |
| 8 | Breast hypoplasia (HP:0003187) | 3.55577292 |
| 9 | Ragged-red muscle fibers (HP:0003200) | 3.43304150 |
| 10 | Abnormality of liposaccharide metabolism (HP:0010968) | 3.35176627 |
| 11 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 3.35176627 |
| 12 | Abnormality of glycolipid metabolism (HP:0010969) | 3.35176627 |
| 13 | Rough bone trabeculation (HP:0100670) | 3.31822193 |
| 14 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.27013412 |
| 15 | Increased serum pyruvate (HP:0003542) | 3.24198760 |
| 16 | Abnormality of glycolysis (HP:0004366) | 3.24198760 |
| 17 | Carpal bone hypoplasia (HP:0001498) | 3.19662968 |
| 18 | Macrocytic anemia (HP:0001972) | 3.16016117 |
| 19 | Hepatocellular necrosis (HP:0001404) | 3.15214602 |
| 20 | Acute necrotizing encephalopathy (HP:0006965) | 3.11280150 |
| 21 | Multiple enchondromatosis (HP:0005701) | 3.09163730 |
| 22 | Hepatic necrosis (HP:0002605) | 3.08663847 |
| 23 | Aplastic anemia (HP:0001915) | 3.07175135 |
| 24 | Increased serum lactate (HP:0002151) | 3.05061425 |
| 25 | Renal Fanconi syndrome (HP:0001994) | 2.97156396 |
| 26 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.91788224 |
| 27 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.91788224 |
| 28 | Mitochondrial inheritance (HP:0001427) | 2.91007167 |
| 29 | Increased CSF lactate (HP:0002490) | 2.86674563 |
| 30 | Selective tooth agenesis (HP:0001592) | 2.86454151 |
| 31 | Petechiae (HP:0000967) | 2.85872196 |
| 32 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.84582286 |
| 33 | Abnormality of the anterior horn cell (HP:0006802) | 2.83843308 |
| 34 | Degeneration of anterior horn cells (HP:0002398) | 2.83843308 |
| 35 | Recurrent abscess formation (HP:0002722) | 2.80042505 |
| 36 | Impulsivity (HP:0100710) | 2.78147788 |
| 37 | Pallor (HP:0000980) | 2.76560714 |
| 38 | Abnormal gallbladder physiology (HP:0012438) | 2.76545877 |
| 39 | Cholecystitis (HP:0001082) | 2.76545877 |
| 40 | Abnormality of macrophages (HP:0004311) | 2.75964961 |
| 41 | Acute encephalopathy (HP:0006846) | 2.75041186 |
| 42 | Microvesicular hepatic steatosis (HP:0001414) | 2.73592062 |
| 43 | Chronic obstructive pulmonary disease (HP:0006510) | 2.70870306 |
| 44 | Obstructive lung disease (HP:0006536) | 2.70870306 |
| 45 | Absent thumb (HP:0009777) | 2.69310515 |
| 46 | Testicular atrophy (HP:0000029) | 2.67298001 |
| 47 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.63812578 |
| 48 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.63196618 |
| 49 | Abnormality of the fetal cardiovascular system (HP:0010948) | 2.59092229 |
| 50 | Abnormal umbilical cord blood vessels (HP:0011403) | 2.59092229 |
| 51 | Single umbilical artery (HP:0001195) | 2.59092229 |
| 52 | Cerebral edema (HP:0002181) | 2.56352789 |
| 53 | Hepatosplenomegaly (HP:0001433) | 2.50411011 |
| 54 | Megaloblastic anemia (HP:0001889) | 2.50246795 |
| 55 | Recurrent bacterial skin infections (HP:0005406) | 2.49523773 |
| 56 | Trismus (HP:0000211) | 2.49013617 |
| 57 | Pancytopenia (HP:0001876) | 2.48789838 |
| 58 | Increased intramyocellular lipid droplets (HP:0012240) | 2.47162227 |
| 59 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.46704865 |
| 60 | Increased hepatocellular lipid droplets (HP:0006565) | 2.46511589 |
| 61 | Increased muscle lipid content (HP:0009058) | 2.45136033 |
| 62 | Premature graying of hair (HP:0002216) | 2.44994816 |
| 63 | 3-Methylglutaconic aciduria (HP:0003535) | 2.44667956 |
| 64 | Hypobetalipoproteinemia (HP:0003563) | 2.43808003 |
| 65 | Nausea (HP:0002018) | 2.42564952 |
| 66 | Lipid accumulation in hepatocytes (HP:0006561) | 2.40423393 |
| 67 | Abnormal number of incisors (HP:0011064) | 2.36826804 |
| 68 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.35709341 |
| 69 | Increased serum ferritin (HP:0003281) | 2.35324209 |
| 70 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 2.35177028 |
| 71 | Lactic acidosis (HP:0003128) | 2.35175544 |
| 72 | Respiratory difficulties (HP:0002880) | 2.32603328 |
| 73 | Hypertensive crisis (HP:0100735) | 2.29612599 |
| 74 | Progressive neurologic deterioration (HP:0002344) | 2.28724094 |
| 75 | Loss of speech (HP:0002371) | 2.27887207 |
| 76 | Irregular epiphyses (HP:0010582) | 2.27828739 |
| 77 | Progressive macrocephaly (HP:0004481) | 2.27515749 |
| 78 | Abnormality of reticulocytes (HP:0004312) | 2.27308675 |
| 79 | Patellar aplasia (HP:0006443) | 2.26019169 |
| 80 | Hypokinesia (HP:0002375) | 2.26008651 |
| 81 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.25780123 |
| 82 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.25780123 |
| 83 | Abnormal protein glycosylation (HP:0012346) | 2.25780123 |
| 84 | Abnormal glycosylation (HP:0012345) | 2.25780123 |
| 85 | CNS demyelination (HP:0007305) | 2.25669057 |
| 86 | Abnormal trabecular bone morphology (HP:0100671) | 2.24623882 |
| 87 | Cholelithiasis (HP:0001081) | 2.23583589 |
| 88 | Abnormality of the umbilical cord (HP:0010881) | 2.19185438 |
| 89 | Vacuolated lymphocytes (HP:0001922) | 2.19165111 |
| 90 | Bone marrow hypocellularity (HP:0005528) | 2.18719231 |
| 91 | Microretrognathia (HP:0000308) | 2.18053575 |
| 92 | Prolonged neonatal jaundice (HP:0006579) | 2.17715530 |
| 93 | Exercise intolerance (HP:0003546) | 2.17186259 |
| 94 | Type I transferrin isoform profile (HP:0003642) | 2.16529395 |
| 95 | Respiratory failure (HP:0002878) | 2.15888737 |
| 96 | Meckel diverticulum (HP:0002245) | 2.15756135 |
| 97 | Increased cerebral lipofuscin (HP:0011813) | 2.15635838 |
| 98 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.15230692 |
| 99 | Duplicated collecting system (HP:0000081) | 2.15039657 |
| 100 | Horseshoe kidney (HP:0000085) | 2.14779008 |
| 101 | Secondary amenorrhea (HP:0000869) | 2.14212575 |
| 102 | Chromsome breakage (HP:0040012) | 2.14065888 |
| 103 | Abnormality of the preputium (HP:0100587) | 2.12752713 |
| 104 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.10120588 |
| 105 | Sparse eyelashes (HP:0000653) | 2.09255628 |
| 106 | Increased IgM level (HP:0003496) | 2.07538836 |
| 107 | Lethargy (HP:0001254) | 2.07086171 |
| 108 | Abnormality of the ileum (HP:0001549) | 2.07082579 |
| 109 | Cellular immunodeficiency (HP:0005374) | 2.05384794 |
| 110 | Abnormal spermatogenesis (HP:0008669) | 2.05331722 |
| 111 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.01422939 |
| 112 | Reduced antithrombin III activity (HP:0001976) | 1.99944926 |
| 113 | Truncus arteriosus (HP:0001660) | 1.99705802 |
| 114 | Broad distal phalanx of finger (HP:0009836) | 1.99698740 |
| 115 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.98830809 |
| 116 | Spastic paraparesis (HP:0002313) | 1.98664233 |
| 117 | Nonimmune hydrops fetalis (HP:0001790) | 1.98455017 |
| 118 | Intrahepatic cholestasis (HP:0001406) | 1.98316917 |
| 119 | Absent epiphyses (HP:0010577) | 1.96502641 |
| 120 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.96502641 |
| 121 | Acute hepatic failure (HP:0006554) | 1.95981435 |
| 122 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.95750606 |
| 123 | Absent radius (HP:0003974) | 1.94550626 |
| 124 | Brushfield spots (HP:0001088) | 1.93468203 |
| 125 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.93311381 |
| 126 | Leukodystrophy (HP:0002415) | 1.92842769 |
| 127 | Colon cancer (HP:0003003) | 1.92230950 |
| 128 | Emotional lability (HP:0000712) | 1.91787727 |
| 129 | Purpura (HP:0000979) | 1.91641859 |
| 130 | Ependymoma (HP:0002888) | 1.91457244 |
| 131 | Eczematoid dermatitis (HP:0000976) | 1.90642456 |
| 132 | Hyperglycinemia (HP:0002154) | 1.90478056 |
| 133 | Progressive muscle weakness (HP:0003323) | 1.90042126 |
| 134 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.89889640 |
| 135 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.89889640 |
| 136 | 11 pairs of ribs (HP:0000878) | 1.89593563 |
| 137 | Severe visual impairment (HP:0001141) | 1.89178553 |
| 138 | Abnormal gallbladder morphology (HP:0012437) | 1.88957827 |
| 139 | Delusions (HP:0000746) | 1.87811676 |
| 140 | Hypergonadotropic hypogonadism (HP:0000815) | 1.87551747 |
| 141 | Fatigue (HP:0012378) | 1.87280784 |
| 142 | Hypoplastic left heart (HP:0004383) | 1.85336436 |
| 143 | Short nail (HP:0001799) | 1.84224631 |
| 144 | Abnormality of chromosome stability (HP:0003220) | 1.84192906 |
| 145 | Neoplasm of the pancreas (HP:0002894) | 1.84136617 |
| 146 | Rhabdomyolysis (HP:0003201) | 1.82985846 |
| 147 | Medulloblastoma (HP:0002885) | 1.82689369 |
| 148 | Abnormality of the distal phalanges of the toes (HP:0010182) | 1.81880459 |
| 149 | Squamous cell carcinoma (HP:0002860) | 1.81315840 |
| 150 | Abnormality of the gallbladder (HP:0005264) | 1.80459336 |
| 151 | Nasal polyposis (HP:0100582) | 1.80395444 |
| 152 | Mediastinal lymphadenopathy (HP:0100721) | 1.78955878 |
| 153 | Recurrent skin infections (HP:0001581) | 1.77480500 |
| 154 | Seborrheic dermatitis (HP:0001051) | 1.77105267 |
| 155 | Urticaria (HP:0001025) | 1.77029636 |
| 156 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.76782682 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.17140357 |
| 2 | VRK2 | 3.96004623 |
| 3 | WEE1 | 3.70904476 |
| 4 | EIF2AK1 | 3.46481009 |
| 5 | NME2 | 3.05355272 |
| 6 | SMG1 | 3.04296565 |
| 7 | STK16 | 3.02524266 |
| 8 | TESK2 | 2.97514244 |
| 9 | BRD4 | 2.93255130 |
| 10 | CDC7 | 2.77691531 |
| 11 | ERN1 | 2.76355883 |
| 12 | TESK1 | 2.74778700 |
| 13 | IRAK3 | 2.61279343 |
| 14 | NEK2 | 2.09245495 |
| 15 | SRPK1 | 2.03956572 |
| 16 | TSSK6 | 2.01976986 |
| 17 | PLK4 | 1.92593024 |
| 18 | TTK | 1.89575539 |
| 19 | PLK1 | 1.88016208 |
| 20 | DYRK3 | 1.86465091 |
| 21 | TRIB3 | 1.85617093 |
| 22 | BCKDK | 1.85590072 |
| 23 | NME1 | 1.79388126 |
| 24 | VRK1 | 1.78098705 |
| 25 | NEK1 | 1.76490425 |
| 26 | MKNK1 | 1.70427131 |
| 27 | TLK1 | 1.68288643 |
| 28 | BRSK2 | 1.64457426 |
| 29 | EIF2AK3 | 1.64019760 |
| 30 | MST1R | 1.62635154 |
| 31 | PDK4 | 1.55350212 |
| 32 | PDK3 | 1.55350212 |
| 33 | INSRR | 1.48405113 |
| 34 | PRKD3 | 1.46684980 |
| 35 | PBK | 1.46295459 |
| 36 | MAP3K3 | 1.45007749 |
| 37 | PASK | 1.40326888 |
| 38 | CDK7 | 1.34713498 |
| 39 | MAP3K11 | 1.33548416 |
| 40 | AURKB | 1.32892502 |
| 41 | ATR | 1.32442610 |
| 42 | AURKA | 1.30527962 |
| 43 | MAP3K8 | 1.29302121 |
| 44 | STK38L | 1.26475077 |
| 45 | LIMK1 | 1.24110245 |
| 46 | RPS6KA4 | 1.23508623 |
| 47 | EPHA2 | 1.20550082 |
| 48 | MKNK2 | 1.19375592 |
| 49 | PRPF4B | 1.14527150 |
| 50 | TYK2 | 1.10913854 |
| 51 | PLK3 | 1.10638965 |
| 52 | BRSK1 | 1.09891239 |
| 53 | PAK4 | 1.09330865 |
| 54 | RPS6KB2 | 1.09099100 |
| 55 | CCNB1 | 1.08764980 |
| 56 | TBK1 | 1.08524597 |
| 57 | MAP3K1 | 1.05974762 |
| 58 | PIM2 | 1.05642904 |
| 59 | BRAF | 1.05298835 |
| 60 | RIPK4 | 1.03837392 |
| 61 | EPHB1 | 1.02765239 |
| 62 | KDR | 1.02022932 |
| 63 | MAP3K12 | 0.97393023 |
| 64 | ICK | 0.95901475 |
| 65 | STK4 | 0.92795374 |
| 66 | BLK | 0.92365934 |
| 67 | IRAK2 | 0.90291880 |
| 68 | CHEK1 | 0.89539266 |
| 69 | CHEK2 | 0.89030191 |
| 70 | PDK2 | 0.86307667 |
| 71 | STK10 | 0.82571366 |
| 72 | ILK | 0.81300793 |
| 73 | CSNK2A2 | 0.80026293 |
| 74 | ZAK | 0.79922878 |
| 75 | CDK4 | 0.79705014 |
| 76 | MAP4K1 | 0.78453333 |
| 77 | SIK3 | 0.77728332 |
| 78 | PAK1 | 0.77527283 |
| 79 | CSNK1G3 | 0.76959073 |
| 80 | PIM1 | 0.76434837 |
| 81 | CSNK2A1 | 0.74630667 |
| 82 | SIK1 | 0.69215991 |
| 83 | ABL2 | 0.64811192 |
| 84 | ACVR1B | 0.63908521 |
| 85 | PDPK1 | 0.63169843 |
| 86 | DYRK1B | 0.61656150 |
| 87 | CDK8 | 0.61040226 |
| 88 | MAP3K10 | 0.60532246 |
| 89 | TAF1 | 0.59766775 |
| 90 | SCYL2 | 0.57348159 |
| 91 | TAOK1 | 0.56791794 |
| 92 | RPS6KA5 | 0.56348541 |
| 93 | TNK2 | 0.54634231 |
| 94 | CDK2 | 0.54117732 |
| 95 | PRKCI | 0.51678719 |
| 96 | TAOK2 | 0.51251910 |
| 97 | IRAK4 | 0.50710574 |
| 98 | CSK | 0.49989874 |
| 99 | DYRK2 | 0.49417521 |
| 100 | MST4 | 0.48335556 |
| 101 | EIF2AK2 | 0.48171794 |
| 102 | MAP2K3 | 0.44907804 |
| 103 | ATM | 0.44100318 |
| 104 | FES | 0.43819087 |
| 105 | LRRK2 | 0.43092692 |
| 106 | ARAF | 0.42042091 |
| 107 | PTK6 | 0.41788457 |
| 108 | CSNK1A1L | 0.41210885 |
| 109 | PRKG2 | 0.41030451 |
| 110 | CDK19 | 0.40417610 |
| 111 | MAPKAPK2 | 0.39850072 |
| 112 | MAPKAPK3 | 0.38368411 |
| 113 | PRKD2 | 0.38252288 |
| 114 | AKT2 | 0.36230628 |
| 115 | FLT3 | 0.35288055 |
| 116 | STK38 | 0.34182706 |
| 117 | CLK1 | 0.33968257 |
| 118 | CDK9 | 0.33661771 |
| 119 | BTK | 0.33474905 |
| 120 | CDK1 | 0.33368246 |
| 121 | KSR2 | 0.32330426 |
| 122 | BMX | 0.31900366 |
| 123 | MAPK11 | 0.31128820 |
| 124 | MAP2K6 | 0.29661495 |
| 125 | PRKCD | 0.29648785 |
| 126 | DAPK1 | 0.29217274 |
| 127 | IKBKB | 0.27647353 |
| 128 | RPS6KA6 | 0.25287761 |
| 129 | GRK6 | 0.24507114 |
| 130 | PNCK | 0.24287019 |
| 131 | ZAP70 | 0.24170137 |
| 132 | ALK | 0.22445332 |
| 133 | NEK9 | 0.22018949 |
| 134 | MARK3 | 0.21744896 |
| 135 | BCR | 0.21389346 |
| 136 | CSNK1E | 0.20458323 |
| 137 | CDK11A | 0.19515629 |
| 138 | CDK14 | 0.19259289 |
| 139 | DAPK3 | 0.19151000 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.34909161 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 4.22727840 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 3.54255550 |
| 4 | Mismatch repair_Homo sapiens_hsa03430 | 3.41354418 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.32928053 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.88728178 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 2.73496260 |
| 8 | Base excision repair_Homo sapiens_hsa03410 | 2.67120545 |
| 9 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.63986020 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.54570380 |
| 11 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.54217586 |
| 12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.35410936 |
| 13 | RNA transport_Homo sapiens_hsa03013 | 2.33644123 |
| 14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.04571169 |
| 15 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.72986269 |
| 16 | Basal transcription factors_Homo sapiens_hsa03022 | 1.72849764 |
| 17 | Cell cycle_Homo sapiens_hsa04110 | 1.65634463 |
| 18 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.64441801 |
| 19 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.61819033 |
| 20 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.56994862 |
| 21 | Parkinsons disease_Homo sapiens_hsa05012 | 1.54715705 |
| 22 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.49569181 |
| 23 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.48504665 |
| 24 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.47570479 |
| 25 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.45346678 |
| 26 | Huntingtons disease_Homo sapiens_hsa05016 | 1.45098374 |
| 27 | Purine metabolism_Homo sapiens_hsa00230 | 1.43659006 |
| 28 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.41724143 |
| 29 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.40785740 |
| 30 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.37841047 |
| 31 | Sulfur relay system_Homo sapiens_hsa04122 | 1.35507742 |
| 32 | Lysosome_Homo sapiens_hsa04142 | 1.33887455 |
| 33 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.30204334 |
| 34 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.29300190 |
| 35 | RNA degradation_Homo sapiens_hsa03018 | 1.26376932 |
| 36 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.25983836 |
| 37 | Carbon metabolism_Homo sapiens_hsa01200 | 1.25670150 |
| 38 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.21693170 |
| 39 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.17884268 |
| 40 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.17642619 |
| 41 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.16906280 |
| 42 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.13955811 |
| 43 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.13095393 |
| 44 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.12545313 |
| 45 | Protein export_Homo sapiens_hsa03060 | 1.12144000 |
| 46 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.10968314 |
| 47 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.10023865 |
| 48 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.96540830 |
| 49 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.96011867 |
| 50 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.95806841 |
| 51 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.95543955 |
| 52 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.92786948 |
| 53 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.91761236 |
| 54 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.87435540 |
| 55 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.84934067 |
| 56 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.84011145 |
| 57 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.83851708 |
| 58 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.80849552 |
| 59 | Shigellosis_Homo sapiens_hsa05131 | 0.80548654 |
| 60 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.80427955 |
| 61 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.77687955 |
| 62 | Alzheimers disease_Homo sapiens_hsa05010 | 0.76581071 |
| 63 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.75171858 |
| 64 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.73066732 |
| 65 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.72744542 |
| 66 | Bladder cancer_Homo sapiens_hsa05219 | 0.71201443 |
| 67 | Apoptosis_Homo sapiens_hsa04210 | 0.69681587 |
| 68 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.68731938 |
| 69 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.68124438 |
| 70 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.68050538 |
| 71 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.68009067 |
| 72 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.67711363 |
| 73 | Peroxisome_Homo sapiens_hsa04146 | 0.67664605 |
| 74 | Metabolic pathways_Homo sapiens_hsa01100 | 0.67291547 |
| 75 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.66099247 |
| 76 | Phagosome_Homo sapiens_hsa04145 | 0.65132145 |
| 77 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.64795800 |
| 78 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.64050977 |
| 79 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.62497786 |
| 80 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.61053376 |
| 81 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.60059955 |
| 82 | Leishmaniasis_Homo sapiens_hsa05140 | 0.58659290 |
| 83 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.57593069 |
| 84 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.56166127 |
| 85 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.55959780 |
| 86 | Tuberculosis_Homo sapiens_hsa05152 | 0.55538462 |
| 87 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.54375785 |
| 88 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.53875749 |
| 89 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.50692951 |
| 90 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.50580160 |
| 91 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.48057945 |
| 92 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.47942355 |
| 93 | Influenza A_Homo sapiens_hsa05164 | 0.45980577 |
| 94 | Legionellosis_Homo sapiens_hsa05134 | 0.45947402 |
| 95 | Galactose metabolism_Homo sapiens_hsa00052 | 0.43991697 |
| 96 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.42987764 |
| 97 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.41115585 |
| 98 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.40338089 |
| 99 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.40328496 |
| 100 | Salmonella infection_Homo sapiens_hsa05132 | 0.39710917 |
| 101 | Endocytosis_Homo sapiens_hsa04144 | 0.38593545 |
| 102 | Measles_Homo sapiens_hsa05162 | 0.38265164 |
| 103 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.38185639 |
| 104 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.38068477 |
| 105 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.37893086 |
| 106 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.37577777 |
| 107 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.35489354 |
| 108 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.35325724 |
| 109 | Hepatitis B_Homo sapiens_hsa05161 | 0.34846019 |
| 110 | Thyroid cancer_Homo sapiens_hsa05216 | 0.34409496 |
| 111 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.33958892 |
| 112 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.33800618 |
| 113 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.33447745 |
| 114 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.33417301 |
| 115 | Retinol metabolism_Homo sapiens_hsa00830 | 0.33364576 |
| 116 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.33181396 |
| 117 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.32865446 |
| 118 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.32555042 |
| 119 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.31609833 |
| 120 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.31217143 |
| 121 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.30092129 |
| 122 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.29911296 |
| 123 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.29056142 |
| 124 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.27715867 |
| 125 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.26377797 |
| 126 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.24774295 |
| 127 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.23090505 |
| 128 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.21324028 |
| 129 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.21036752 |
| 130 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.20115749 |
| 131 | Histidine metabolism_Homo sapiens_hsa00340 | 0.18904171 |
| 132 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.17745202 |
| 133 | HTLV-I infection_Homo sapiens_hsa05166 | 0.17633886 |
| 134 | Other glycan degradation_Homo sapiens_hsa00511 | 0.14705600 |
| 135 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.14465127 |

