MTX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.92105219
2rRNA modification (GO:0000154)4.62751346
3maturation of SSU-rRNA (GO:0030490)4.52381644
4DNA strand elongation involved in DNA replication (GO:0006271)4.49188016
5formation of translation preinitiation complex (GO:0001731)4.29731099
6DNA strand elongation (GO:0022616)4.28284681
7nucleobase biosynthetic process (GO:0046112)4.25812408
8telomere maintenance via semi-conservative replication (GO:0032201)4.25406097
9purine nucleobase biosynthetic process (GO:0009113)4.16903125
10proteasome assembly (GO:0043248)4.09745036
11DNA replication initiation (GO:0006270)4.05464528
12ribosomal large subunit biogenesis (GO:0042273)3.96545891
13rRNA methylation (GO:0031167)3.96470905
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.96455192
15ribosomal small subunit assembly (GO:0000028)3.93571190
16protein maturation by protein folding (GO:0022417)3.86627972
17folic acid-containing compound biosynthetic process (GO:0009396)3.86433214
18DNA replication checkpoint (GO:0000076)3.85724273
19positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.81234645
20regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.81039070
21GDP-mannose metabolic process (GO:0019673)3.78928263
22chaperone-mediated protein transport (GO:0072321)3.75366378
23anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.74785632
24pentose metabolic process (GO:0019321)3.74171638
25ribosomal small subunit biogenesis (GO:0042274)3.73885157
26negative regulation of ligase activity (GO:0051352)3.71853740
27negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.71853740
28viral transcription (GO:0019083)3.68648180
29ribonucleoprotein complex biogenesis (GO:0022613)3.66512652
30chromatin remodeling at centromere (GO:0031055)3.66470930
31translational termination (GO:0006415)3.64696528
32spliceosomal snRNP assembly (GO:0000387)3.63991925
33DNA unwinding involved in DNA replication (GO:0006268)3.62199256
34telomere maintenance via recombination (GO:0000722)3.62186120
35regulation of cellular amino acid metabolic process (GO:0006521)3.61305577
36CENP-A containing nucleosome assembly (GO:0034080)3.61133894
37ribosome biogenesis (GO:0042254)3.59542990
38negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.59358473
39DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.55770523
40DNA replication-dependent nucleosome assembly (GO:0006335)3.50420888
41DNA replication-dependent nucleosome organization (GO:0034723)3.50420888
42intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.49714070
43signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.49714070
44signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.48071879
45signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.48071879
46signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.48071879
47telomere maintenance via telomere lengthening (GO:0010833)3.46824525
48IMP biosynthetic process (GO:0006188)3.45117305
49translational elongation (GO:0006414)3.44762280
50signal transduction involved in DNA damage checkpoint (GO:0072422)3.43242175
51signal transduction involved in DNA integrity checkpoint (GO:0072401)3.43242175
52pyrimidine-containing compound salvage (GO:0008655)3.42374905
53pyrimidine nucleoside salvage (GO:0043097)3.42374905
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.42220522
55signal transduction involved in cell cycle checkpoint (GO:0072395)3.37522865
56transcription-coupled nucleotide-excision repair (GO:0006283)3.37043539
57establishment of integrated proviral latency (GO:0075713)3.36061820
58rRNA processing (GO:0006364)3.35832762
59regulation of mitochondrial translation (GO:0070129)3.35670713
60positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.34458244
61mitotic recombination (GO:0006312)3.32312101
62guanosine-containing compound biosynthetic process (GO:1901070)3.32263260
63mitotic metaphase plate congression (GO:0007080)3.31674565
64translational initiation (GO:0006413)3.31552971
65pseudouridine synthesis (GO:0001522)3.27814865
66nucleotide-excision repair, DNA gap filling (GO:0006297)3.24089937
67folic acid metabolic process (GO:0046655)3.24029917
68nucleobase-containing small molecule interconversion (GO:0015949)3.23755047
69rRNA metabolic process (GO:0016072)3.23503683
70DNA replication-independent nucleosome organization (GO:0034724)3.22757037
71DNA replication-independent nucleosome assembly (GO:0006336)3.22757037
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.22645009
73pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.21525521
74positive regulation of ligase activity (GO:0051351)3.21229787
75SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19791621
76ribosome assembly (GO:0042255)3.18621550
77histone exchange (GO:0043486)3.17666219
78translation (GO:0006412)3.17533212
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.17274930
80nucleoside salvage (GO:0043174)3.16930637
817-methylguanosine mRNA capping (GO:0006370)3.14665047
82cullin deneddylation (GO:0010388)3.13628872
83cotranslational protein targeting to membrane (GO:0006613)3.11783994
84protein targeting to ER (GO:0045047)3.09669172
85regulation of ubiquitin-protein transferase activity (GO:0051438)3.09536609
86pteridine-containing compound biosynthetic process (GO:0042559)3.08249825
877-methylguanosine RNA capping (GO:0009452)3.08070589
88RNA capping (GO:0036260)3.08070589
89pentose-phosphate shunt (GO:0006098)3.07526880
90IMP metabolic process (GO:0046040)3.07141033
91cellular component biogenesis (GO:0044085)3.07005307
92binding of sperm to zona pellucida (GO:0007339)3.06865645
93glycine metabolic process (GO:0006544)3.03949254
94termination of RNA polymerase III transcription (GO:0006386)3.03778363
95transcription elongation from RNA polymerase III promoter (GO:0006385)3.03778363
96cell cycle G1/S phase transition (GO:0044843)3.02696890
97G1/S transition of mitotic cell cycle (GO:0000082)3.02696890
98establishment of protein localization to mitochondrial membrane (GO:0090151)3.02577136
99nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02248333
100protein localization to kinetochore (GO:0034501)3.00710802
101regulation of ligase activity (GO:0051340)2.99480449
102peptidyl-histidine modification (GO:0018202)2.99196396
103antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.98404311
104mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96917388
105* protein targeting to mitochondrion (GO:0006626)2.96153102
106protein localization to endoplasmic reticulum (GO:0070972)2.95093312
107regulation of superoxide anion generation (GO:0032928)2.94827492
108viral life cycle (GO:0019058)2.93276216
109pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.93203270
110cellular protein complex disassembly (GO:0043624)2.92530947
111response to peptidoglycan (GO:0032494)2.91687653
112protein deneddylation (GO:0000338)2.91262298
113UTP biosynthetic process (GO:0006228)2.91178365
114L-methionine salvage (GO:0071267)2.90886863
115L-methionine biosynthetic process (GO:0071265)2.90886863
116amino acid salvage (GO:0043102)2.90886863
117mitotic nuclear envelope disassembly (GO:0007077)2.90014041
118spliceosomal complex assembly (GO:0000245)2.89744683
119regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.89607322
120GTP biosynthetic process (GO:0006183)2.87016454
121pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.86144215
122nucleotide salvage (GO:0043173)2.84034909
123NADPH regeneration (GO:0006740)2.82426856
124deoxyribose phosphate biosynthetic process (GO:0046385)2.81306296
1252-deoxyribonucleotide biosynthetic process (GO:0009265)2.81306296
126pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.76749021
127NIK/NF-kappaB signaling (GO:0038061)2.74678251
128CTP biosynthetic process (GO:0006241)2.72962416
129CTP metabolic process (GO:0046036)2.72962416
130energy coupled proton transport, down electrochemical gradient (GO:0015985)2.72383507
131ATP synthesis coupled proton transport (GO:0015986)2.72383507
132base-excision repair, AP site formation (GO:0006285)2.67460990
133UV protection (GO:0009650)2.65886120
134pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.65786713
135* establishment of protein localization to mitochondrion (GO:0072655)2.64701163
136pyrimidine nucleotide catabolic process (GO:0006244)2.58571280
137positive regulation of cell cycle arrest (GO:0071158)2.55697163
138iron-sulfur cluster assembly (GO:0016226)2.55336880
139metallo-sulfur cluster assembly (GO:0031163)2.55336880
140protein retention in ER lumen (GO:0006621)2.54168255
141establishment of viral latency (GO:0019043)2.52902441
142* protein localization to mitochondrion (GO:0070585)2.52504899
143pinocytosis (GO:0006907)2.52132955
144negative regulation of protein ubiquitination (GO:0031397)2.51375145
145Golgi transport vesicle coating (GO:0048200)2.49094838
146COPI coating of Golgi vesicle (GO:0048205)2.49094838
147negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.47409422
148nuclear envelope reassembly (GO:0031468)2.47187944
149mitotic nuclear envelope reassembly (GO:0007084)2.47187944
150deoxyribonucleotide catabolic process (GO:0009264)2.46646247
151amyloid precursor protein catabolic process (GO:0042987)2.46150824
152antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.46122755
153regulation of cellular amine metabolic process (GO:0033238)2.45544122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.88361885
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.21671664
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.95796368
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59578708
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.45294481
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.31274909
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.20401896
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.13779436
9MYC_18358816_ChIP-ChIP_MESCs_Mouse3.09948722
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.00326092
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.94937651
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86782724
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85071364
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83440199
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.80050898
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.80018409
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64054464
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.55881957
19XRN2_22483619_ChIP-Seq_HELA_Human2.49004845
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42990950
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42094075
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32315000
23VDR_23849224_ChIP-Seq_CD4+_Human2.22172229
24DCP1A_22483619_ChIP-Seq_HELA_Human2.16064207
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15750974
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.11525809
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10704713
28VDR_21846776_ChIP-Seq_THP-1_Human2.09205913
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08630639
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.08031987
31FOXP3_21729870_ChIP-Seq_TREG_Human2.01231646
32GABP_19822575_ChIP-Seq_HepG2_Human1.96814484
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94502199
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91036280
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.89418720
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.87246531
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85981902
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83670819
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78832130
40LXR_22292898_ChIP-Seq_THP-1_Human1.76056446
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73178103
42TTF2_22483619_ChIP-Seq_HELA_Human1.72981634
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70786762
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70295242
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.69914993
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61362386
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59315613
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57760533
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57356879
50AR_21909140_ChIP-Seq_LNCAP_Human1.56988197
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55352821
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.52722614
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51908975
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48798081
55* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47830464
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46887644
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.42363946
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.41817585
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41161411
60CIITA_25753668_ChIP-Seq_RAJI_Human1.40255734
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36962440
62P68_20966046_ChIP-Seq_HELA_Human1.36956376
63RACK7_27058665_Chip-Seq_MCF-7_Human1.35891132
64* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35432959
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34819735
66ELK1_19687146_ChIP-ChIP_HELA_Human1.33943453
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33796161
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33609633
69ZNF263_19887448_ChIP-Seq_K562_Human1.31440086
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30579306
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29784646
72* KDM5A_27292631_Chip-Seq_BREAST_Human1.26864920
73BCL6_27268052_Chip-Seq_Bcells_Human1.26438147
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26144966
75* MAF_26560356_Chip-Seq_TH2_Human1.22789959
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21554962
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.20845349
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20803449
79BCOR_27268052_Chip-Seq_Bcells_Human1.20474779
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18650747
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18604251
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17838052
83SPI1_23547873_ChIP-Seq_NB4_Human1.15994743
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14248811
85ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12192853
86* FOXP1_21924763_ChIP-Seq_HESCs_Human1.11454648
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11285593
88MAF_26560356_Chip-Seq_TH1_Human1.11245229
89* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11052580
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10665144
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10174771
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09133710
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08060803
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07409580
95CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07257352
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06579269
97CTCF_26484167_Chip-Seq_Bcells_Mouse1.05725237
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05462037
99VDR_24763502_ChIP-Seq_THP-1_Human1.05361375
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04989972
101* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04841198
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03993093
103UTX_26944678_Chip-Seq_JUKART_Human1.02047667
104CTCF_21964334_Chip-Seq_Bcells_Human1.01679567
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01217311
106YY1_22570637_ChIP-Seq_MALME-3M_Human1.00194354
107STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00038180
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99908854
109MYC_22102868_ChIP-Seq_BL_Human0.98757905
110PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97701146
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97437245
112SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97344728
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96595163
114TFEB_21752829_ChIP-Seq_HELA_Human0.95864919
115MYC_18940864_ChIP-ChIP_HL60_Human0.95520542
116* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94926372
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91573351
118SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91141489
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90201071
120OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90061508
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88860393
122ELK1_22589737_ChIP-Seq_MCF10A_Human0.87567398
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87499922
124HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87327735
125NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86460487
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84292552
127CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83968951
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83779219
129KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.82684139
130GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81949836
131TET1_21451524_ChIP-Seq_MESCs_Mouse0.80091990

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.35663628
2MP0003806_abnormal_nucleotide_metabolis4.62883829
3MP0004957_abnormal_blastocyst_morpholog4.28564501
4MP0010094_abnormal_chromosome_stability4.01673697
5MP0003111_abnormal_nucleus_morphology3.92052795
6MP0005058_abnormal_lysosome_morphology3.70389395
7MP0003077_abnormal_cell_cycle3.59129266
8MP0008057_abnormal_DNA_replication3.17672281
9MP0008058_abnormal_DNA_repair3.00354729
10MP0008932_abnormal_embryonic_tissue2.84880669
11MP0008007_abnormal_cellular_replicative2.80542367
12MP0005410_abnormal_fertilization2.78059167
13MP0003191_abnormal_cellular_cholesterol2.76238011
14MP0008877_abnormal_DNA_methylation2.38339033
15MP0001730_embryonic_growth_arrest2.28634992
16MP0003436_decreased_susceptibility_to2.17715677
17MP0005360_urolithiasis2.03577409
18MP0003718_maternal_effect1.96530070
19MP0003172_abnormal_lysosome_physiology1.94559717
20MP0002132_abnormal_respiratory_system1.93982111
21MP0003186_abnormal_redox_activity1.93871531
22MP0000678_abnormal_parathyroid_gland1.88628011
23MP0003786_premature_aging1.87482687
24MP0004858_abnormal_nervous_system1.84031308
25MP0006036_abnormal_mitochondrial_physio1.82402357
26MP0000350_abnormal_cell_proliferation1.70858359
27MP0001929_abnormal_gametogenesis1.69335096
28MP0005085_abnormal_gallbladder_physiolo1.60864664
29MP0002396_abnormal_hematopoietic_system1.60460266
30MP0004133_heterotaxia1.58487671
31MP0002877_abnormal_melanocyte_morpholog1.58435859
32MP0002419_abnormal_innate_immunity1.58006366
33MP0001835_abnormal_antigen_presentation1.55557042
34MP0010352_gastrointestinal_tract_polyps1.54231096
35MP0009333_abnormal_splenocyte_physiolog1.54132402
36MP0003123_paternal_imprinting1.54004891
37MP0002160_abnormal_reproductive_system1.53020629
38MP0002139_abnormal_hepatobiliary_system1.51301752
39MP0004233_abnormal_muscle_weight1.51154229
40MP0002210_abnormal_sex_determination1.50123290
41MP0005025_abnormal_response_to1.47771199
42MP0009278_abnormal_bone_marrow1.46389138
43MP0001293_anophthalmia1.44771608
44MP0006292_abnormal_olfactory_placode1.43246097
45* MP0002080_prenatal_lethality1.41670775
46MP0000313_abnormal_cell_death1.41593560
47MP0009785_altered_susceptibility_to1.41302082
48MP0001849_ear_inflammation1.40912606
49MP0003656_abnormal_erythrocyte_physiolo1.39448877
50MP0001145_abnormal_male_reproductive1.39346005
51MP0001697_abnormal_embryo_size1.36929375
52MP0001764_abnormal_homeostasis1.35582898
53MP0006035_abnormal_mitochondrial_morpho1.34485621
54MP0008875_abnormal_xenobiotic_pharmacok1.34381452
55MP0001661_extended_life_span1.31664120
56MP0002148_abnormal_hypersensitivity_rea1.31166588
57MP0000490_abnormal_crypts_of1.30697616
58MP0010030_abnormal_orbit_morphology1.29090536
59MP0002019_abnormal_tumor_incidence1.28275926
60MP0003698_abnormal_male_reproductive1.28157048
61MP0001672_abnormal_embryogenesis/_devel1.26550053
62MP0005380_embryogenesis_phenotype1.26550053
63MP0003075_altered_response_to1.25204939
64MP0005266_abnormal_metabolism1.24818897
65MP0009840_abnormal_foam_cell1.22958589
66MP0000358_abnormal_cell_content/1.20507843
67MP0005464_abnormal_platelet_physiology1.19870272
68MP0010307_abnormal_tumor_latency1.16797456
69MP0006082_CNS_inflammation1.16729312
70MP0005397_hematopoietic_system_phenotyp1.13839677
71MP0001545_abnormal_hematopoietic_system1.13839677
72MP0000653_abnormal_sex_gland1.12616775
73MP0000372_irregular_coat_pigmentation1.11657513
74MP0005075_abnormal_melanosome_morpholog1.11382096
75MP0002085_abnormal_embryonic_tissue1.11086471
76MP0002723_abnormal_immune_serum1.10626546
77MP0002420_abnormal_adaptive_immunity1.09980955
78MP0005501_abnormal_skin_physiology1.09578675
79MP0001819_abnormal_immune_cell1.09178978
80MP0005670_abnormal_white_adipose1.08957134
81MP0005083_abnormal_biliary_tract1.07655415
82MP0003984_embryonic_growth_retardation1.07363646
83MP0000681_abnormal_thyroid_gland1.07001847
84MP0000343_altered_response_to1.06810971
85MP0005000_abnormal_immune_tolerance1.06140864
86MP0002452_abnormal_antigen_presenting1.05274696
87MP0004381_abnormal_hair_follicle1.05023955
88MP0005389_reproductive_system_phenotype1.04061333
89MP0000685_abnormal_immune_system1.02602377
90MP0002088_abnormal_embryonic_growth/wei1.01968542
91MP0002796_impaired_skin_barrier1.01543716
92MP0003303_peritoneal_inflammation1.01158326
93MP0008469_abnormal_protein_level1.00910314
94MP0000015_abnormal_ear_pigmentation1.00530616
95MP0001845_abnormal_inflammatory_respons0.99441738
96MP0005332_abnormal_amino_acid0.97925705
97MP0002405_respiratory_system_inflammati0.97479414
98MP0003705_abnormal_hypodermis_morpholog0.95593669
99MP0002653_abnormal_ependyma_morphology0.95242322
100MP0003448_altered_tumor_morphology0.94294636
101MP0000716_abnormal_immune_system0.93116403
102MP0003453_abnormal_keratinocyte_physiol0.93039090
103MP0000689_abnormal_spleen_morphology0.91490240
104MP0004947_skin_inflammation0.91199451
105MP0002722_abnormal_immune_system0.90141737
106MP0001533_abnormal_skeleton_physiology0.89810367
107* MP0005319_abnormal_enzyme/_coenzyme0.88703289
108MP0001853_heart_inflammation0.88424978
109MP0005671_abnormal_response_to0.87913941
110MP0000598_abnormal_liver_morphology0.87685589
111MP0005365_abnormal_bile_salt0.87497003
112MP0002161_abnormal_fertility/fecundity0.87226915
113MP0001727_abnormal_embryo_implantation0.87132109
114MP0002086_abnormal_extraembryonic_tissu0.86314545
115MP0009697_abnormal_copulation0.85326230
116MP0004197_abnormal_fetal_growth/weight/0.85236636
117MP0002163_abnormal_gland_morphology0.85039185
118MP0002084_abnormal_developmental_patter0.84815288
119MP0004019_abnormal_vitamin_homeostasis0.82610439
120MP0000703_abnormal_thymus_morphology0.81607034
121MP0005584_abnormal_enzyme/coenzyme_acti0.80594632
122MP0003221_abnormal_cardiomyocyte_apopto0.80304307
123MP0008004_abnormal_stomach_pH0.80044551
124MP0005408_hypopigmentation0.79462610
125MP0001790_abnormal_immune_system0.77646337
126MP0005387_immune_system_phenotype0.77646337
127MP0002398_abnormal_bone_marrow0.75762516
128MP0001800_abnormal_humoral_immune0.75716409
129MP0003763_abnormal_thymus_physiology0.75017360
130MP0000750_abnormal_muscle_regeneration0.74305433
131MP0009672_abnormal_birth_weight0.74089809
132MP0003566_abnormal_cell_adhesion0.73114605
133MP0004185_abnormal_adipocyte_glucose0.72750258
134MP0005377_hearing/vestibular/ear_phenot0.72724613
135MP0003878_abnormal_ear_physiology0.72724613
136MP0002429_abnormal_blood_cell0.72557176
137MP0005376_homeostasis/metabolism_phenot0.70955259
138MP0000858_altered_metastatic_potential0.70659052
139MP0004147_increased_porphyrin_level0.69010644
140MP0003315_abnormal_perineum_morphology0.68554731
141MP0004808_abnormal_hematopoietic_stem0.67205698
142MP0003119_abnormal_digestive_system0.65769818
143MP0008260_abnormal_autophagy0.65359817
144MP0000609_abnormal_liver_physiology0.63333916
145MP0002282_abnormal_trachea_morphology0.63068167
146MP0002111_abnormal_tail_morphology0.62416728
147MP0005384_cellular_phenotype0.62116896
148MP0003567_abnormal_fetal_cardiomyocyte0.61654795
149MP0009643_abnormal_urine_homeostasis0.61495010
150MP0005451_abnormal_body_composition0.60586110
151MP0005636_abnormal_mineral_homeostasis0.60210911
152MP0002092_abnormal_eye_morphology0.59086910
153MP0003011_delayed_dark_adaptation0.58433110
154MP0000477_abnormal_intestine_morphology0.58022592
155MP0009379_abnormal_foot_pigmentation0.57881600

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.50714103
2Reticulocytopenia (HP:0001896)4.30709099
3Oral leukoplakia (HP:0002745)4.17134720
4Abnormality of cells of the erythroid lineage (HP:0012130)4.12080884
5Abnormal number of erythroid precursors (HP:0012131)3.99944865
6Vertebral compression fractures (HP:0002953)3.58830279
7Cerebral hypomyelination (HP:0006808)3.56585045
8Breast hypoplasia (HP:0003187)3.55577292
9Ragged-red muscle fibers (HP:0003200)3.43304150
10Abnormality of liposaccharide metabolism (HP:0010968)3.35176627
11Abnormality of glycosphingolipid metabolism (HP:0004343)3.35176627
12Abnormality of glycolipid metabolism (HP:0010969)3.35176627
13Rough bone trabeculation (HP:0100670)3.31822193
14Abnormality of pyrimidine metabolism (HP:0004353)3.27013412
15Increased serum pyruvate (HP:0003542)3.24198760
16Abnormality of glycolysis (HP:0004366)3.24198760
17Carpal bone hypoplasia (HP:0001498)3.19662968
18Macrocytic anemia (HP:0001972)3.16016117
19Hepatocellular necrosis (HP:0001404)3.15214602
20Acute necrotizing encephalopathy (HP:0006965)3.11280150
21Multiple enchondromatosis (HP:0005701)3.09163730
22Hepatic necrosis (HP:0002605)3.08663847
23Aplastic anemia (HP:0001915)3.07175135
24Increased serum lactate (HP:0002151)3.05061425
25Renal Fanconi syndrome (HP:0001994)2.97156396
26Decreased activity of mitochondrial respiratory chain (HP:0008972)2.91788224
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.91788224
28Mitochondrial inheritance (HP:0001427)2.91007167
29Increased CSF lactate (HP:0002490)2.86674563
30Selective tooth agenesis (HP:0001592)2.86454151
31Petechiae (HP:0000967)2.85872196
32Abnormal mitochondria in muscle tissue (HP:0008316)2.84582286
33Abnormality of the anterior horn cell (HP:0006802)2.83843308
34Degeneration of anterior horn cells (HP:0002398)2.83843308
35Recurrent abscess formation (HP:0002722)2.80042505
36Impulsivity (HP:0100710)2.78147788
37Pallor (HP:0000980)2.76560714
38Abnormal gallbladder physiology (HP:0012438)2.76545877
39Cholecystitis (HP:0001082)2.76545877
40Abnormality of macrophages (HP:0004311)2.75964961
41Acute encephalopathy (HP:0006846)2.75041186
42Microvesicular hepatic steatosis (HP:0001414)2.73592062
43Chronic obstructive pulmonary disease (HP:0006510)2.70870306
44Obstructive lung disease (HP:0006536)2.70870306
45Absent thumb (HP:0009777)2.69310515
46Testicular atrophy (HP:0000029)2.67298001
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.63812578
48Abnormality of the heme biosynthetic pathway (HP:0010472)2.63196618
49Abnormality of the fetal cardiovascular system (HP:0010948)2.59092229
50Abnormal umbilical cord blood vessels (HP:0011403)2.59092229
51Single umbilical artery (HP:0001195)2.59092229
52Cerebral edema (HP:0002181)2.56352789
53Hepatosplenomegaly (HP:0001433)2.50411011
54Megaloblastic anemia (HP:0001889)2.50246795
55Recurrent bacterial skin infections (HP:0005406)2.49523773
56Trismus (HP:0000211)2.49013617
57Pancytopenia (HP:0001876)2.48789838
58Increased intramyocellular lipid droplets (HP:0012240)2.47162227
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46704865
60Increased hepatocellular lipid droplets (HP:0006565)2.46511589
61Increased muscle lipid content (HP:0009058)2.45136033
62Premature graying of hair (HP:0002216)2.44994816
633-Methylglutaconic aciduria (HP:0003535)2.44667956
64Hypobetalipoproteinemia (HP:0003563)2.43808003
65Nausea (HP:0002018)2.42564952
66Lipid accumulation in hepatocytes (HP:0006561)2.40423393
67Abnormal number of incisors (HP:0011064)2.36826804
68Hypoplasia of the capital femoral epiphysis (HP:0003090)2.35709341
69Increased serum ferritin (HP:0003281)2.35324209
70Abnormality of monocarboxylic acid metabolism (HP:0010996)2.35177028
71Lactic acidosis (HP:0003128)2.35175544
72Respiratory difficulties (HP:0002880)2.32603328
73Hypertensive crisis (HP:0100735)2.29612599
74Progressive neurologic deterioration (HP:0002344)2.28724094
75Loss of speech (HP:0002371)2.27887207
76Irregular epiphyses (HP:0010582)2.27828739
77Progressive macrocephaly (HP:0004481)2.27515749
78Abnormality of reticulocytes (HP:0004312)2.27308675
79Patellar aplasia (HP:0006443)2.26019169
80Hypokinesia (HP:0002375)2.26008651
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.25780123
82Abnormal protein N-linked glycosylation (HP:0012347)2.25780123
83Abnormal protein glycosylation (HP:0012346)2.25780123
84Abnormal glycosylation (HP:0012345)2.25780123
85CNS demyelination (HP:0007305)2.25669057
86Abnormal trabecular bone morphology (HP:0100671)2.24623882
87Cholelithiasis (HP:0001081)2.23583589
88Abnormality of the umbilical cord (HP:0010881)2.19185438
89Vacuolated lymphocytes (HP:0001922)2.19165111
90Bone marrow hypocellularity (HP:0005528)2.18719231
91Microretrognathia (HP:0000308)2.18053575
92Prolonged neonatal jaundice (HP:0006579)2.17715530
93Exercise intolerance (HP:0003546)2.17186259
94Type I transferrin isoform profile (HP:0003642)2.16529395
95Respiratory failure (HP:0002878)2.15888737
96Meckel diverticulum (HP:0002245)2.15756135
97Increased cerebral lipofuscin (HP:0011813)2.15635838
98Aplasia/Hypoplasia of the patella (HP:0006498)2.15230692
99Duplicated collecting system (HP:0000081)2.15039657
100Horseshoe kidney (HP:0000085)2.14779008
101Secondary amenorrhea (HP:0000869)2.14212575
102Chromsome breakage (HP:0040012)2.14065888
103Abnormality of the preputium (HP:0100587)2.12752713
104Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10120588
105Sparse eyelashes (HP:0000653)2.09255628
106Increased IgM level (HP:0003496)2.07538836
107Lethargy (HP:0001254)2.07086171
108Abnormality of the ileum (HP:0001549)2.07082579
109Cellular immunodeficiency (HP:0005374)2.05384794
110Abnormal spermatogenesis (HP:0008669)2.05331722
111Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.01422939
112Reduced antithrombin III activity (HP:0001976)1.99944926
113Truncus arteriosus (HP:0001660)1.99705802
114Broad distal phalanx of finger (HP:0009836)1.99698740
115Increased neuronal autofluorescent lipopigment (HP:0002074)1.98830809
116Spastic paraparesis (HP:0002313)1.98664233
117Nonimmune hydrops fetalis (HP:0001790)1.98455017
118Intrahepatic cholestasis (HP:0001406)1.98316917
119Absent epiphyses (HP:0010577)1.96502641
120Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.96502641
121Acute hepatic failure (HP:0006554)1.95981435
122Abnormality of aromatic amino acid family metabolism (HP:0004338)1.95750606
123Absent radius (HP:0003974)1.94550626
124Brushfield spots (HP:0001088)1.93468203
125Chromosomal breakage induced by crosslinking agents (HP:0003221)1.93311381
126Leukodystrophy (HP:0002415)1.92842769
127Colon cancer (HP:0003003)1.92230950
128Emotional lability (HP:0000712)1.91787727
129Purpura (HP:0000979)1.91641859
130Ependymoma (HP:0002888)1.91457244
131Eczematoid dermatitis (HP:0000976)1.90642456
132Hyperglycinemia (HP:0002154)1.90478056
133Progressive muscle weakness (HP:0003323)1.90042126
134Abnormal respiratory epithelium morphology (HP:0012253)1.89889640
135Abnormal respiratory motile cilium morphology (HP:0005938)1.89889640
13611 pairs of ribs (HP:0000878)1.89593563
137Severe visual impairment (HP:0001141)1.89178553
138Abnormal gallbladder morphology (HP:0012437)1.88957827
139Delusions (HP:0000746)1.87811676
140Hypergonadotropic hypogonadism (HP:0000815)1.87551747
141Fatigue (HP:0012378)1.87280784
142Hypoplastic left heart (HP:0004383)1.85336436
143Short nail (HP:0001799)1.84224631
144Abnormality of chromosome stability (HP:0003220)1.84192906
145Neoplasm of the pancreas (HP:0002894)1.84136617
146Rhabdomyolysis (HP:0003201)1.82985846
147Medulloblastoma (HP:0002885)1.82689369
148Abnormality of the distal phalanges of the toes (HP:0010182)1.81880459
149Squamous cell carcinoma (HP:0002860)1.81315840
150Abnormality of the gallbladder (HP:0005264)1.80459336
151Nasal polyposis (HP:0100582)1.80395444
152Mediastinal lymphadenopathy (HP:0100721)1.78955878
153Recurrent skin infections (HP:0001581)1.77480500
154Seborrheic dermatitis (HP:0001051)1.77105267
155Urticaria (HP:0001025)1.77029636
156Elevated erythrocyte sedimentation rate (HP:0003565)1.76782682

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.17140357
2VRK23.96004623
3WEE13.70904476
4EIF2AK13.46481009
5NME23.05355272
6SMG13.04296565
7STK163.02524266
8TESK22.97514244
9BRD42.93255130
10CDC72.77691531
11ERN12.76355883
12TESK12.74778700
13IRAK32.61279343
14NEK22.09245495
15SRPK12.03956572
16TSSK62.01976986
17PLK41.92593024
18TTK1.89575539
19PLK11.88016208
20DYRK31.86465091
21TRIB31.85617093
22BCKDK1.85590072
23NME11.79388126
24VRK11.78098705
25NEK11.76490425
26MKNK11.70427131
27TLK11.68288643
28BRSK21.64457426
29EIF2AK31.64019760
30MST1R1.62635154
31PDK41.55350212
32PDK31.55350212
33INSRR1.48405113
34PRKD31.46684980
35PBK1.46295459
36MAP3K31.45007749
37PASK1.40326888
38CDK71.34713498
39MAP3K111.33548416
40AURKB1.32892502
41ATR1.32442610
42AURKA1.30527962
43MAP3K81.29302121
44STK38L1.26475077
45LIMK11.24110245
46RPS6KA41.23508623
47EPHA21.20550082
48MKNK21.19375592
49PRPF4B1.14527150
50TYK21.10913854
51PLK31.10638965
52BRSK11.09891239
53PAK41.09330865
54RPS6KB21.09099100
55CCNB11.08764980
56TBK11.08524597
57MAP3K11.05974762
58PIM21.05642904
59BRAF1.05298835
60RIPK41.03837392
61EPHB11.02765239
62KDR1.02022932
63MAP3K120.97393023
64ICK0.95901475
65STK40.92795374
66BLK0.92365934
67IRAK20.90291880
68CHEK10.89539266
69CHEK20.89030191
70PDK20.86307667
71STK100.82571366
72ILK0.81300793
73CSNK2A20.80026293
74ZAK0.79922878
75CDK40.79705014
76MAP4K10.78453333
77SIK30.77728332
78PAK10.77527283
79CSNK1G30.76959073
80PIM10.76434837
81CSNK2A10.74630667
82SIK10.69215991
83ABL20.64811192
84ACVR1B0.63908521
85PDPK10.63169843
86DYRK1B0.61656150
87CDK80.61040226
88MAP3K100.60532246
89TAF10.59766775
90SCYL20.57348159
91TAOK10.56791794
92RPS6KA50.56348541
93TNK20.54634231
94CDK20.54117732
95PRKCI0.51678719
96TAOK20.51251910
97IRAK40.50710574
98CSK0.49989874
99DYRK20.49417521
100MST40.48335556
101EIF2AK20.48171794
102MAP2K30.44907804
103ATM0.44100318
104FES0.43819087
105LRRK20.43092692
106ARAF0.42042091
107PTK60.41788457
108CSNK1A1L0.41210885
109PRKG20.41030451
110CDK190.40417610
111MAPKAPK20.39850072
112MAPKAPK30.38368411
113PRKD20.38252288
114AKT20.36230628
115FLT30.35288055
116STK380.34182706
117CLK10.33968257
118CDK90.33661771
119BTK0.33474905
120CDK10.33368246
121KSR20.32330426
122BMX0.31900366
123MAPK110.31128820
124MAP2K60.29661495
125PRKCD0.29648785
126DAPK10.29217274
127IKBKB0.27647353
128RPS6KA60.25287761
129GRK60.24507114
130PNCK0.24287019
131ZAP700.24170137
132ALK0.22445332
133NEK90.22018949
134MARK30.21744896
135BCR0.21389346
136CSNK1E0.20458323
137CDK11A0.19515629
138CDK140.19259289
139DAPK30.19151000

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.34909161
2DNA replication_Homo sapiens_hsa030304.22727840
3Ribosome_Homo sapiens_hsa030103.54255550
4Mismatch repair_Homo sapiens_hsa034303.41354418
5RNA polymerase_Homo sapiens_hsa030203.32928053
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88728178
7Spliceosome_Homo sapiens_hsa030402.73496260
8Base excision repair_Homo sapiens_hsa034102.67120545
9Pyrimidine metabolism_Homo sapiens_hsa002402.63986020
10Homologous recombination_Homo sapiens_hsa034402.54570380
11One carbon pool by folate_Homo sapiens_hsa006702.54217586
12Nucleotide excision repair_Homo sapiens_hsa034202.35410936
13RNA transport_Homo sapiens_hsa030132.33644123
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.04571169
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.72986269
16Basal transcription factors_Homo sapiens_hsa030221.72849764
17Cell cycle_Homo sapiens_hsa041101.65634463
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.64441801
19Oxidative phosphorylation_Homo sapiens_hsa001901.61819033
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.56994862
21Parkinsons disease_Homo sapiens_hsa050121.54715705
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49569181
23Fanconi anemia pathway_Homo sapiens_hsa034601.48504665
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47570479
25Folate biosynthesis_Homo sapiens_hsa007901.45346678
26Huntingtons disease_Homo sapiens_hsa050161.45098374
27Purine metabolism_Homo sapiens_hsa002301.43659006
28Non-homologous end-joining_Homo sapiens_hsa034501.41724143
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.40785740
30Biosynthesis of amino acids_Homo sapiens_hsa012301.37841047
31Sulfur relay system_Homo sapiens_hsa041221.35507742
32Lysosome_Homo sapiens_hsa041421.33887455
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30204334
34Pentose phosphate pathway_Homo sapiens_hsa000301.29300190
35RNA degradation_Homo sapiens_hsa030181.26376932
36Glutathione metabolism_Homo sapiens_hsa004801.25983836
37Carbon metabolism_Homo sapiens_hsa012001.25670150
38Sulfur metabolism_Homo sapiens_hsa009201.21693170
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17884268
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17642619
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.16906280
42Pyruvate metabolism_Homo sapiens_hsa006201.13955811
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13095393
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12545313
45Protein export_Homo sapiens_hsa030601.12144000
46Caffeine metabolism_Homo sapiens_hsa002321.10968314
47Selenocompound metabolism_Homo sapiens_hsa004501.10023865
48Epstein-Barr virus infection_Homo sapiens_hsa051690.96540830
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96011867
50mRNA surveillance pathway_Homo sapiens_hsa030150.95806841
51Vibrio cholerae infection_Homo sapiens_hsa051100.95543955
52Systemic lupus erythematosus_Homo sapiens_hsa053220.92786948
53p53 signaling pathway_Homo sapiens_hsa041150.91761236
54Vitamin B6 metabolism_Homo sapiens_hsa007500.87435540
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84934067
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84011145
57Propanoate metabolism_Homo sapiens_hsa006400.83851708
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.80849552
59Shigellosis_Homo sapiens_hsa051310.80548654
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80427955
61Arginine and proline metabolism_Homo sapiens_hsa003300.77687955
62Alzheimers disease_Homo sapiens_hsa050100.76581071
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75171858
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73066732
65Fructose and mannose metabolism_Homo sapiens_hsa000510.72744542
66Bladder cancer_Homo sapiens_hsa052190.71201443
67Apoptosis_Homo sapiens_hsa042100.69681587
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68731938
69Chemical carcinogenesis_Homo sapiens_hsa052040.68124438
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68050538
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68009067
72Collecting duct acid secretion_Homo sapiens_hsa049660.67711363
73Peroxisome_Homo sapiens_hsa041460.67664605
74Metabolic pathways_Homo sapiens_hsa011000.67291547
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66099247
76Phagosome_Homo sapiens_hsa041450.65132145
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64795800
78Acute myeloid leukemia_Homo sapiens_hsa052210.64050977
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62497786
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61053376
81Osteoclast differentiation_Homo sapiens_hsa043800.60059955
82Leishmaniasis_Homo sapiens_hsa051400.58659290
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57593069
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56166127
85Fatty acid degradation_Homo sapiens_hsa000710.55959780
86Tuberculosis_Homo sapiens_hsa051520.55538462
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54375785
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53875749
89Steroid biosynthesis_Homo sapiens_hsa001000.50692951
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50580160
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48057945
92Antigen processing and presentation_Homo sapiens_hsa046120.47942355
93Influenza A_Homo sapiens_hsa051640.45980577
94Legionellosis_Homo sapiens_hsa051340.45947402
95Galactose metabolism_Homo sapiens_hsa000520.43991697
96Oocyte meiosis_Homo sapiens_hsa041140.42987764
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41115585
98Viral carcinogenesis_Homo sapiens_hsa052030.40338089
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.40328496
100Salmonella infection_Homo sapiens_hsa051320.39710917
101Endocytosis_Homo sapiens_hsa041440.38593545
102Measles_Homo sapiens_hsa051620.38265164
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38185639
104Sphingolipid metabolism_Homo sapiens_hsa006000.38068477
105Primary immunodeficiency_Homo sapiens_hsa053400.37893086
106Herpes simplex infection_Homo sapiens_hsa051680.37577777
107Phenylalanine metabolism_Homo sapiens_hsa003600.35489354
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35325724
109Hepatitis B_Homo sapiens_hsa051610.34846019
110Thyroid cancer_Homo sapiens_hsa052160.34409496
111Linoleic acid metabolism_Homo sapiens_hsa005910.33958892
112Non-small cell lung cancer_Homo sapiens_hsa052230.33800618
113beta-Alanine metabolism_Homo sapiens_hsa004100.33447745
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33417301
115Retinol metabolism_Homo sapiens_hsa008300.33364576
116Tyrosine metabolism_Homo sapiens_hsa003500.33181396
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32865446
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32555042
119Fatty acid elongation_Homo sapiens_hsa000620.31609833
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31217143
121N-Glycan biosynthesis_Homo sapiens_hsa005100.30092129
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29911296
123Arachidonic acid metabolism_Homo sapiens_hsa005900.29056142
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27715867
125Tryptophan metabolism_Homo sapiens_hsa003800.26377797
126Fat digestion and absorption_Homo sapiens_hsa049750.24774295
127Vitamin digestion and absorption_Homo sapiens_hsa049770.23090505
128Fatty acid metabolism_Homo sapiens_hsa012120.21324028
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.21036752
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20115749
131Histidine metabolism_Homo sapiens_hsa003400.18904171
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17745202
133HTLV-I infection_Homo sapiens_hsa051660.17633886
134Other glycan degradation_Homo sapiens_hsa005110.14705600
135Cardiac muscle contraction_Homo sapiens_hsa042600.14465127

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