ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of cell aging (GO:0090344)	5.26176970
2	adenosine receptor signaling pathway (GO:0001973)	5.15426974
3	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	5.09087827
4	cellular response to ATP (GO:0071318)	4.95863600
5	gonadal mesoderm development (GO:0007506)	4.83680076
6	GDP-mannose metabolic process (GO:0019673)	4.81321087
7	adenine nucleotide transport (GO:0051503)	4.65038464
8	purine ribonucleotide transport (GO:0015868)	4.50325686
9	positive regulation of protein kinase C signaling (GO:0090037)	4.46044391
10	DNA strand renaturation (GO:0000733)	4.39655440
11	NIK/NF-kappaB signaling (GO:0038061)	4.29434324
12	response to peptidoglycan (GO:0032494)	4.25086780
13	regulation of RIG-I signaling pathway (GO:0039535)	4.22759045
14	melanin biosynthetic process (GO:0042438)	4.21807009
15	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	3.95867738
16	positive regulation of interleukin-8 secretion (GO:2000484)	3.83930225
17	G-protein coupled purinergic receptor signaling pathway (GO:0035588)	3.83559861
18	UV protection (GO:0009650)	3.81299784
19	secondary metabolite biosynthetic process (GO:0044550)	3.80923423
20	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.78785609
21	oligosaccharide catabolic process (GO:0009313)	3.75911103
22	base-excision repair, AP site formation (GO:0006285)	3.69980795
23	negative regulation of interleukin-8 production (GO:0032717)	3.68394353
24	regulation of interferon-beta biosynthetic process (GO:0045357)	3.64923776
25	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.60537235
26	melanin metabolic process (GO:0006582)	3.59880795
27	nucleoside transmembrane transport (GO:1901642)	3.58556105
28	purine nucleotide transport (GO:0015865)	3.58305910
29	protein retention in ER lumen (GO:0006621)	3.43827454
30	nucleotide transmembrane transport (GO:1901679)	3.41025049
31	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.38958203
32	positive regulation of T cell chemotaxis (GO:0010820)	3.32106348
33	regulation of T cell chemotaxis (GO:0010819)	3.32106348
34	regulation of interleukin-8 secretion (GO:2000482)	3.27324183
35	positive regulation of odontogenesis (GO:0042482)	3.22938552
36	mitotic cell cycle arrest (GO:0071850)	3.17371870
37	negative regulation of macrophage differentiation (GO:0045650)	3.17147410
38	purinergic receptor signaling pathway (GO:0035587)	3.13989573
39	response to ATP (GO:0033198)	3.12406286
40	granulocyte differentiation (GO:0030851)	3.12040623
41	regulation of cell aging (GO:0090342)	3.10150161
42	nucleoside transport (GO:0015858)	3.09704390
43	monocyte chemotaxis (GO:0002548)	3.09001233
44	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.08518626
45	negative regulation of necroptotic process (GO:0060546)	3.00685929
46	lipopolysaccharide biosynthetic process (GO:0009103)	2.97809586
47	hyaluronan catabolic process (GO:0030214)	2.95223014
48	positive regulation of protein sumoylation (GO:0033235)	2.92149688
49	heme transport (GO:0015886)	2.89879655
50	rRNA modification (GO:0000154)	2.87849238
51	mannosylation (GO:0097502)	2.85970737
52	actin nucleation (GO:0045010)	2.85888030
53	grooming behavior (GO:0007625)	2.84940528
54	rRNA methylation (GO:0031167)	2.84481223
55	positive regulation of T cell migration (GO:2000406)	2.84291696
56	nucleoside salvage (GO:0043174)	2.83938251
57	iron coordination entity transport (GO:1901678)	2.83806994
58	negative regulation of tumor necrosis factor production (GO:0032720)	2.82952732
59	regulation of T cell migration (GO:2000404)	2.82758984
60	lipopolysaccharide metabolic process (GO:0008653)	2.82139886
61	lens fiber cell differentiation (GO:0070306)	2.81106779
62	negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)	2.80143326
63	folic acid transport (GO:0015884)	2.79684499
64	detection of light stimulus involved in visual perception (GO:0050908)	2.79549927
65	detection of light stimulus involved in sensory perception (GO:0050962)	2.79549927
66	nucleotide salvage (GO:0043173)	2.78874009
67	purine nucleotide salvage (GO:0032261)	2.78682497
68	negative regulation of defense response to virus (GO:0050687)	2.75363485
69	proline biosynthetic process (GO:0006561)	2.72947815
70	type B pancreatic cell proliferation (GO:0044342)	2.71820829
71	pyrimidine nucleoside salvage (GO:0043097)	2.71560476
72	pyrimidine-containing compound salvage (GO:0008655)	2.71560476
73	regulation of interferon-beta production (GO:0032648)	2.71437573
74	purine deoxyribonucleotide catabolic process (GO:0009155)	2.64959729
75	N-acetylneuraminate metabolic process (GO:0006054)	2.64693951
76	regulation of skeletal muscle contraction (GO:0014819)	2.62721944
77	negative regulation of interleukin-12 production (GO:0032695)	2.60980133
78	response to parathyroid hormone (GO:0071107)	2.60655698
79	anatomical structure regression (GO:0060033)	2.60340634
80	positive regulation of protein homooligomerization (GO:0032464)	2.59638723
81	necroptotic process (GO:0070266)	2.59150266
82	cellular metabolic compound salvage (GO:0043094)	2.58479771
83	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.57858651
84	glycosphingolipid catabolic process (GO:0046479)	2.57253540
85	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.54609812
86	regulation of interleukin-8 production (GO:0032677)	2.54208913
87	cellular response to exogenous dsRNA (GO:0071360)	2.53651540
88	positive regulation of lymphocyte migration (GO:2000403)	2.51865748
89	peptidyl-glutamic acid carboxylation (GO:0017187)	2.50861030
90	protein carboxylation (GO:0018214)	2.50861030
91	pentose-phosphate shunt (GO:0006098)	2.49274638
92	neutrophil mediated immunity (GO:0002446)	2.48988915
93	lipopolysaccharide-mediated signaling pathway (GO:0031663)	2.48968923
94	amino sugar catabolic process (GO:0046348)	2.48958914
95	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.47651610
96	negative regulation of chemokine production (GO:0032682)	2.47625608
97	positive regulation of T cell apoptotic process (GO:0070234)	2.46452338
98	negative regulation of metanephros development (GO:0072217)	2.44050762
99	regulation of monocyte differentiation (GO:0045655)	2.43108857
100	negative regulation of response to biotic stimulus (GO:0002832)	2.43063977

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_21846776_ChIP-Seq_THP-1_Human	3.54102719
2	LXR_22292898_ChIP-Seq_THP-1_Human	2.48796354
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.47945109
4	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.45085370
5	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.42787534
6	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.33180393
7	VDR_24763502_ChIP-Seq_THP-1_Human	2.13841783
8	XRN2_22483619_ChIP-Seq_HELA_Human	2.07002627
9	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.05633408
10	P68_20966046_ChIP-Seq_HELA_Human	2.03808190
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.99738387
12	BCL6_27268052_Chip-Seq_Bcells_Human	1.98001351
13	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.91971501
14	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.91161063
15	MAF_26560356_Chip-Seq_TH2_Human	1.88700198
16	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.88220036
17	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.87196271
18	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.86500703
19	BCOR_27268052_Chip-Seq_Bcells_Human	1.84543954
20	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.79612303
21	RACK7_27058665_Chip-Seq_MCF-7_Human	1.79413524
22	MAF_26560356_Chip-Seq_TH1_Human	1.77564019
23	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.77544944
24	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.76215386
25	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.73398358
26	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.71681745
27	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.70405065
28	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.67757975
29	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.65964550
30	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.65679415
31	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.62445697
32	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.61346518
33	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.59905662
34	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.59412454
35	E2F1_20622854_ChIP-Seq_HELA_Human	1.58815037
36	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.57631904
37	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.52428528
38	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.50351459
39	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.48459447
40	UTX_26944678_Chip-Seq_JUKART_Human	1.47072947
41	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.46815909
42	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.45828811
43	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.43351056
44	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.40930156
45	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.40820677
46	TFEB_21752829_ChIP-Seq_HELA_Human	1.40733025
47	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.40183928
48	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.39055855
49	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.38692475
50	PHF8_20622854_ChIP-Seq_HELA_Human	1.38313885
51	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.38161629
52	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.37687969
53	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.36723521
54	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.36323786
55	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.35773832
56	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.34999506
57	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.34541302
58	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.34502903
59	CTCF_21964334_Chip-Seq_Bcells_Human	1.33954805
60	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.33592641
61	DCP1A_22483619_ChIP-Seq_HELA_Human	1.33556214
62	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.33442802
63	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.33440224
64	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.33423581
65	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.33395684
66	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.29373014
67	TP53_22127205_ChIP-Seq_IMR90_Human	1.27742835
68	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.27476749
69	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.27466707
70	MYC_22102868_ChIP-Seq_BL_Human	1.26379983
71	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.26276852
72	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.25979652
73	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.25804161
74	SPI1_23547873_ChIP-Seq_NB4_Human	1.25023271
75	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.24875584
76	KDM2B_26808549_Chip-Seq_DND41_Human	1.24748890
77	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.24467840
78	NCOR1_26117541_ChIP-Seq_K562_Human	1.24204623
79	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.23742803
80	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.22206520
81	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.21581589
82	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.20104687
83	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.19012467
84	ATF3_27146783_Chip-Seq_COLON_Human	1.18832138
85	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.17868848
86	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.16617624
87	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.16585865
88	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.15422302
89	CTCF_20526341_ChIP-Seq_ESCs_Human	1.15139006
90	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13747928
91	GABP_19822575_ChIP-Seq_HepG2_Human	1.13011464
92	SMC4_20622854_ChIP-Seq_HELA_Human	1.12788141
93	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.12733227
94	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.11354903
95	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.10629088
96	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.10474086
97	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09693532
98	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.09338857
99	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.08249099
100	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.08139282

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001986_abnormal_taste_sensitivity	5.18576873
2	MP0005171_absent_coat_pigmentation	4.45729314
3	MP0003136_yellow_coat_color	4.06860154
4	MP0005174_abnormal_tail_pigmentation	3.92342507
5	MP0005423_abnormal_somatic_nervous	3.88572090
6	MP0005058_abnormal_lysosome_morphology	3.65039095
7	MP0003806_abnormal_nucleotide_metabolis	2.67290427
8	MP0005083_abnormal_biliary_tract	2.40231616
9	MP0006082_CNS_inflammation	2.23430039
10	MP0003172_abnormal_lysosome_physiology	2.22095353
11	MP0000516_abnormal_urinary_system	2.06742563
12	MP0005367_renal/urinary_system_phenotyp	2.06742563
13	MP0009278_abnormal_bone_marrow	2.02357239
14	MP0000537_abnormal_urethra_morphology	1.99861595
15	MP0000750_abnormal_muscle_regeneration	1.85742161
16	MP0003303_peritoneal_inflammation	1.84333968
17	MP0003436_decreased_susceptibility_to	1.75696466
18	MP0000751_myopathy	1.69379879
19	MP0008875_abnormal_xenobiotic_pharmacok	1.55419489
20	MP0002419_abnormal_innate_immunity	1.53266407
21	MP0003656_abnormal_erythrocyte_physiolo	1.50757860
22	MP0009333_abnormal_splenocyte_physiolog	1.50133919
23	MP0003448_altered_tumor_morphology	1.47485894
24	MP0002148_abnormal_hypersensitivity_rea	1.45475908
25	MP0001545_abnormal_hematopoietic_system	1.44875477
26	MP0005397_hematopoietic_system_phenotyp	1.44875477
27	MP0001348_abnormal_lacrimal_gland	1.44716029
28	MP0003315_abnormal_perineum_morphology	1.43863941
29	MP0001958_emphysema	1.43420630
30	MP0001661_extended_life_span	1.41446370
31	MP0000015_abnormal_ear_pigmentation	1.40052385
32	MP0005584_abnormal_enzyme/coenzyme_acti	1.36750598
33	MP0003075_altered_response_to	1.34809016
34	MP0002822_catalepsy	1.34067433
35	MP0000538_abnormal_urinary_bladder	1.33937724
36	MP0001968_abnormal_touch/_nociception	1.32977122
37	MP0002877_abnormal_melanocyte_morpholog	1.29890110
38	MP0005025_abnormal_response_to	1.28229009
39	MP0003191_abnormal_cellular_cholesterol	1.25507772
40	MP0003045_fibrosis	1.24812990
41	MP0005084_abnormal_gallbladder_morpholo	1.24454860
42	MP0003453_abnormal_keratinocyte_physiol	1.20590670
43	MP0009840_abnormal_foam_cell	1.20562714
44	MP0008260_abnormal_autophagy	1.18033442
45	MP0000685_abnormal_immune_system	1.12091990
46	MP0001756_abnormal_urination	1.11945896
47	MP0000343_altered_response_to	1.11590188
48	MP0005165_increased_susceptibility_to	1.10206858
49	MP0009764_decreased_sensitivity_to	1.09337678
50	MP0003091_abnormal_cell_migration	1.07632555
51	MP0009384_cardiac_valve_regurgitation	1.06635983
52	MP0000013_abnormal_adipose_tissue	1.06409935
53	MP0001188_hyperpigmentation	1.06376249
54	MP0001853_heart_inflammation	1.05051210
55	MP0003011_delayed_dark_adaptation	1.04196839
56	MP0002405_respiratory_system_inflammati	1.01901591
57	MP0005330_cardiomyopathy	1.00623669
58	MP0005257_abnormal_intraocular_pressure	0.99643959
59	MP0009785_altered_susceptibility_to	0.99220406
60	MP0005310_abnormal_salivary_gland	0.98604661
61	MP0002723_abnormal_immune_serum	0.98370551
62	MP0002452_abnormal_antigen_presenting	0.96429313
63	MP0002638_abnormal_pupillary_reflex	0.95946412
64	MP0008004_abnormal_stomach_pH	0.95604941
65	MP0008469_abnormal_protein_level	0.91196818
66	MP0002736_abnormal_nociception_after	0.90937011
67	MP0001845_abnormal_inflammatory_respons	0.88617046
68	MP0008789_abnormal_olfactory_epithelium	0.88051905
69	MP0001542_abnormal_bone_strength	0.87998799
70	MP0000858_altered_metastatic_potential	0.87803353
71	MP0005164_abnormal_response_to	0.86106378
72	MP0001905_abnormal_dopamine_level	0.85516634
73	MP0000747_muscle_weakness	0.85508878
74	MP0005000_abnormal_immune_tolerance	0.82649131
75	MP0000358_abnormal_cell_content/	0.79915853
76	MP0005671_abnormal_response_to	0.77794040
77	MP0005464_abnormal_platelet_physiology	0.77074952
78	MP0005365_abnormal_bile_salt	0.76849710
79	MP0002420_abnormal_adaptive_immunity	0.76671001
80	MP0001819_abnormal_immune_cell	0.75779287
81	MP0002653_abnormal_ependyma_morphology	0.75044565
82	MP0003566_abnormal_cell_adhesion	0.74839532
83	MP0002019_abnormal_tumor_incidence	0.74214813
84	MP0009931_abnormal_skin_appearance	0.72702144
85	MP0005319_abnormal_enzyme/_coenzyme	0.72689706
86	MP0000003_abnormal_adipose_tissue	0.72396942
87	MP0005409_darkened_coat_color	0.71512220
88	MP0001790_abnormal_immune_system	0.71161148
89	MP0005387_immune_system_phenotype	0.71161148
90	MP0001664_abnormal_digestion	0.71019617
91	MP0003786_premature_aging	0.70677247
92	MP0004808_abnormal_hematopoietic_stem	0.70079839
93	MP0005023_abnormal_wound_healing	0.69382828
94	MP0004381_abnormal_hair_follicle	0.67348951
95	MP0010030_abnormal_orbit_morphology	0.66150133
96	MP0001502_abnormal_circadian_rhythm	0.63957022
97	MP0002429_abnormal_blood_cell	0.63745427
98	MP0005451_abnormal_body_composition	0.63692622
99	MP0001533_abnormal_skeleton_physiology	0.62895102
100	MP0000465_gastrointestinal_hemorrhage	0.61869482

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Testicular atrophy (HP:0000029)	5.20883655
2	Rib fusion (HP:0000902)	5.09143340
3	Abnormality of glycosphingolipid metabolism (HP:0004343)	4.15443532
4	Abnormality of glycolipid metabolism (HP:0010969)	4.15443532
5	Abnormality of liposaccharide metabolism (HP:0010968)	4.15443532
6	Abnormality of polysaccharide metabolism (HP:0011012)	4.10766315
7	Abnormality of glycosaminoglycan metabolism (HP:0004371)	4.10766315
8	Abnormality of mucopolysaccharide metabolism (HP:0011020)	4.10766315
9	Ulnar bowing (HP:0003031)	3.82296579
10	Mucopolysacchariduria (HP:0008155)	3.79876727
11	Urinary glycosaminoglycan excretion (HP:0003541)	3.79876727
12	Facial diplegia (HP:0001349)	3.57535779
13	Thin bony cortex (HP:0002753)	3.52570383
14	Male infertility (HP:0003251)	3.51463789
15	Akinesia (HP:0002304)	3.51345137
16	Attenuation of retinal blood vessels (HP:0007843)	3.41152451
17	Vertebral compression fractures (HP:0002953)	3.37557537
18	Poikiloderma (HP:0001029)	3.29907541
19	Cervical subluxation (HP:0003308)	3.26805581
20	Vaginal fistula (HP:0004320)	3.22003017
21	Dysostosis multiplex (HP:0000943)	3.19603534
22	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.19060278
23	Joint stiffness (HP:0001387)	3.04734196
24	Abnormal number of erythroid precursors (HP:0012131)	2.98280923
25	Rectal fistula (HP:0100590)	2.91716280
26	Rectovaginal fistula (HP:0000143)	2.91716280
27	Squamous cell carcinoma (HP:0002860)	2.85145508
28	Mesangial abnormality (HP:0001966)	2.73455828
29	Dyschromatopsia (HP:0007641)	2.71544244
30	Abnormality of the costochondral junction (HP:0000919)	2.70411613
31	Increased cerebral lipofuscin (HP:0011813)	2.69595446
32	Turricephaly (HP:0000262)	2.65923148
33	Abnormality of the intrinsic pathway (HP:0010989)	2.63262570
34	Coronal craniosynostosis (HP:0004440)	2.62417974
35	Intestinal fistula (HP:0100819)	2.59038220
36	Annular pancreas (HP:0001734)	2.55717780
37	Hypochromic anemia (HP:0001931)	2.54783041
38	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.54043754
39	Facial hemangioma (HP:0000329)	2.53194328
40	Autoimmune thrombocytopenia (HP:0001973)	2.50385023
41	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.48762472
42	Loss of speech (HP:0002371)	2.48124583
43	Reduced antithrombin III activity (HP:0001976)	2.47936825
44	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.45529569
45	Abnormality of placental membranes (HP:0011409)	2.45060149
46	Amniotic constriction ring (HP:0009775)	2.45060149
47	Anteriorly placed anus (HP:0001545)	2.43888431
48	Abnormality of cells of the erythroid lineage (HP:0012130)	2.39026495
49	Hemorrhage of the eye (HP:0011885)	2.36356370
50	Popliteal pterygium (HP:0009756)	2.33873294
51	Renal Fanconi syndrome (HP:0001994)	2.33481606
52	Aplasia of the musculature (HP:0100854)	2.32114241
53	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.30068356
54	Epiphyseal stippling (HP:0010655)	2.28466532
55	Prolonged neonatal jaundice (HP:0006579)	2.27853824
56	Abnormality of macrophages (HP:0004311)	2.27498222
57	Vacuolated lymphocytes (HP:0001922)	2.23801757
58	Type I transferrin isoform profile (HP:0003642)	2.21277235
59	Protrusio acetabuli (HP:0003179)	2.20839934
60	Joint hemorrhage (HP:0005261)	2.20776534
61	Diminished movement (HP:0002374)	2.20001071
62	Abnormal epiphyseal ossification (HP:0010656)	2.18373355
63	Retinal dysplasia (HP:0007973)	2.14671213
64	Delayed epiphyseal ossification (HP:0002663)	2.10359806
65	Increased IgM level (HP:0003496)	2.09733146
66	Abnormal protein N-linked glycosylation (HP:0012347)	2.06879748
67	Abnormal protein glycosylation (HP:0012346)	2.06879748
68	Abnormal glycosylation (HP:0012345)	2.06879748
69	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.06879748
70	J-shaped sella turcica (HP:0002680)	2.03222316
71	Nonimmune hydrops fetalis (HP:0001790)	2.02913984
72	Cholelithiasis (HP:0001081)	2.02794247
73	Thrombocytosis (HP:0001894)	2.01647399
74	Increased serum ferritin (HP:0003281)	2.00747282
75	Bowing of the arm (HP:0006488)	2.00090730
76	Bowed forearm bones (HP:0003956)	2.00090730
77	Abnormal albumin level (HP:0012116)	1.99617835
78	Hypoalbuminemia (HP:0003073)	1.99617835
79	Petechiae (HP:0000967)	1.98064180
80	Abnormality of iron homeostasis (HP:0011031)	1.91988954
81	Global brain atrophy (HP:0002283)	1.91528269
82	Obstructive lung disease (HP:0006536)	1.91027318
83	Chronic obstructive pulmonary disease (HP:0006510)	1.91027318
84	Thoracic kyphosis (HP:0002942)	1.90265107
85	Choanal stenosis (HP:0000452)	1.89089084
86	Elevated erythrocyte sedimentation rate (HP:0003565)	1.87819467
87	Hypochromic microcytic anemia (HP:0004840)	1.87187878
88	Increased intramyocellular lipid droplets (HP:0012240)	1.86636002
89	Cheilitis (HP:0100825)	1.84894576
90	Zonular cataract (HP:0010920)	1.83675598
91	Ovoid vertebral bodies (HP:0003300)	1.83137089
92	Hypoplastic heart (HP:0001961)	1.82262799
93	Hepatosplenomegaly (HP:0001433)	1.81275402
94	Neonatal respiratory distress (HP:0002643)	1.80664369
95	Congenital stationary night blindness (HP:0007642)	1.80524767
96	Elevated alkaline phosphatase (HP:0003155)	1.79284037
97	Asymmetric septal hypertrophy (HP:0001670)	1.78800737
98	Prolonged partial thromboplastin time (HP:0003645)	1.78179540
99	Severe visual impairment (HP:0001141)	1.78179350
100	Neoplasm of head and neck (HP:0012288)	1.77560081

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	4.56731424
2	TESK2	4.04608984
3	MAP2K3	3.64577663
4	GRK6	2.89764844
5	BCKDK	2.83185701
6	PIM2	2.78402798
7	IRAK3	2.75928663
8	ERN1	2.57703328
9	BLK	2.50803513
10	TBK1	2.15073469
11	TAOK2	2.08841537
12	CCNB1	2.07377570
13	MAP3K11	1.97157917
14	NME2	1.94947373
15	EPHB2	1.90768905
16	VRK2	1.83321794
17	EPHB1	1.74386236
18	MUSK	1.73255326
19	TGFBR2	1.69816530
20	PAK4	1.59629491
21	MAP3K3	1.55953347
22	ZAP70	1.51945487
23	MAP4K1	1.48058174
24	MAP2K7	1.45197129
25	IKBKE	1.43532258
26	GRK7	1.31487095
27	IRAK4	1.30990632
28	WNK4	1.28404285
29	DYRK1B	1.26098243
30	CDK19	1.23966958
31	MAP2K6	1.21242565
32	MAP2K4	1.21191210
33	EPHA2	1.18715728
34	CSK	1.16620943
35	ADRBK1	1.15945373
36	FES	1.14407828
37	IRAK2	1.13368745
38	KIT	1.11236467
39	TAOK1	1.09705795
40	TAOK3	1.07954001
41	PRKD2	1.07166182
42	MAPK7	1.05420332
43	TXK	1.02436641
44	SMG1	0.92807188
45	TESK1	0.92506768
46	MAP3K5	0.91096279
47	KDR	0.90010106
48	ABL2	0.87604703
49	IKBKB	0.86266694
50	SIK1	0.83812305
51	MAP3K1	0.82664264
52	SCYL2	0.79937288
53	SIK2	0.76194534
54	RPS6KC1	0.74995742
55	RPS6KL1	0.74995742
56	MAPK12	0.74178798
57	MAP3K6	0.73345528
58	ADRBK2	0.71885818
59	DAPK1	0.71129450
60	MYLK	0.71050026
61	TYK2	0.67916460
62	DAPK2	0.66656664
63	RPS6KA6	0.66232297
64	FLT3	0.64674784
65	DAPK3	0.63859914
66	DDR2	0.59959257
67	CSF1R	0.59056352
68	NEK9	0.58437841
69	LYN	0.58262588
70	RPS6KA2	0.57393513
71	PAK1	0.57330873
72	STK16	0.54713457
73	CDK4	0.51899324
74	NEK2	0.50186572
75	PRKD1	0.48801732
76	BCR	0.47518085
77	CDK11A	0.46848056
78	MAP3K12	0.45687302
79	PIK3CG	0.44497066
80	SYK	0.43288707
81	TRIB3	0.43206713
82	PIM1	0.43140567
83	MAP3K14	0.41142733
84	CDK15	0.40507278
85	IRAK1	0.40360277
86	MST1R	0.39500499
87	AURKA	0.38771972
88	SIK3	0.37352598
89	CDK18	0.36540938
90	HIPK2	0.36517724
91	PRKCD	0.36367551
92	LIMK1	0.36007025
93	RAF1	0.35296907
94	CDK14	0.34752495
95	GSK3A	0.34468141
96	LRRK2	0.34258249
97	PTK2B	0.33480448
98	DYRK3	0.33383184
99	MAPK11	0.32829923
100	JAK3	0.31394062

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	5.49678317
2	Glycosaminoglycan degradation_Homo sapiens_hsa00531	5.10595236
3	Sulfur relay system_Homo sapiens_hsa04122	4.57548717
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.44453679
5	Lysosome_Homo sapiens_hsa04142	2.73612662
6	Other glycan degradation_Homo sapiens_hsa00511	2.68642473
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.53854590
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.51126060
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.50192904
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.42625864
11	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.37279720
12	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.31824211
13	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.20735147
14	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.91899650
15	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.78606533
16	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.68412457
17	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.41303245
18	Collecting duct acid secretion_Homo sapiens_hsa04966	1.40261704
19	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.39700258
20	Sphingolipid metabolism_Homo sapiens_hsa00600	1.35954368
21	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.34764262
22	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.30068912
23	Bladder cancer_Homo sapiens_hsa05219	1.29580520
24	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.28385513
25	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.27819517
26	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.18307451
27	Rheumatoid arthritis_Homo sapiens_hsa05323	1.17831060
28	Galactose metabolism_Homo sapiens_hsa00052	1.10455313
29	TNF signaling pathway_Homo sapiens_hsa04668	1.09582440
30	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.05734764
31	Osteoclast differentiation_Homo sapiens_hsa04380	1.05435640
32	Ribosome_Homo sapiens_hsa03010	1.02257639
33	RNA polymerase_Homo sapiens_hsa03020	1.01275158
34	Fatty acid elongation_Homo sapiens_hsa00062	1.00621165
35	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.97322068
36	Vibrio cholerae infection_Homo sapiens_hsa05110	0.97140674
37	Base excision repair_Homo sapiens_hsa03410	0.94049459
38	Oxidative phosphorylation_Homo sapiens_hsa00190	0.93680066
39	Pertussis_Homo sapiens_hsa05133	0.91887639
40	Malaria_Homo sapiens_hsa05144	0.87563418
41	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.84399022
42	Proteasome_Homo sapiens_hsa03050	0.83754171
43	Pentose phosphate pathway_Homo sapiens_hsa00030	0.81358705
44	Phagosome_Homo sapiens_hsa04145	0.80954283
45	Shigellosis_Homo sapiens_hsa05131	0.80563441
46	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.78632540
47	Influenza A_Homo sapiens_hsa05164	0.75891255
48	Tuberculosis_Homo sapiens_hsa05152	0.74967726
49	Leishmaniasis_Homo sapiens_hsa05140	0.71478402
50	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.68232617
51	Hepatitis B_Homo sapiens_hsa05161	0.66982739
52	Folate biosynthesis_Homo sapiens_hsa00790	0.66578036
53	Salmonella infection_Homo sapiens_hsa05132	0.66360334
54	Sulfur metabolism_Homo sapiens_hsa00920	0.65319110
55	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.58852079
56	Pyrimidine metabolism_Homo sapiens_hsa00240	0.58083683
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.57277518
58	Metabolic pathways_Homo sapiens_hsa01100	0.54522505
59	Parkinsons disease_Homo sapiens_hsa05012	0.54175520
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53735054
61	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53082263
62	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.52353085
63	Apoptosis_Homo sapiens_hsa04210	0.50850205
64	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.49285798
65	Endocytosis_Homo sapiens_hsa04144	0.49198080
66	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.48557996
67	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.46422186
68	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.45445351
69	Legionellosis_Homo sapiens_hsa05134	0.44199664
70	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41778211
71	Toxoplasmosis_Homo sapiens_hsa05145	0.41089335
72	Measles_Homo sapiens_hsa05162	0.39347947
73	Herpes simplex infection_Homo sapiens_hsa05168	0.38535338
74	Steroid biosynthesis_Homo sapiens_hsa00100	0.37452422
75	Fatty acid metabolism_Homo sapiens_hsa01212	0.36736412
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.32681318
77	Hepatitis C_Homo sapiens_hsa05160	0.31916512
78	Pyruvate metabolism_Homo sapiens_hsa00620	0.31541059
79	Carbon metabolism_Homo sapiens_hsa01200	0.30342830
80	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.29656770
81	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.28882349
82	Alzheimers disease_Homo sapiens_hsa05010	0.28848960
83	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.28650170
84	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.28634049
85	Selenocompound metabolism_Homo sapiens_hsa00450	0.28570661
86	Purine metabolism_Homo sapiens_hsa00230	0.27542404
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.27279095
88	Graft-versus-host disease_Homo sapiens_hsa05332	0.25930341
89	Glutathione metabolism_Homo sapiens_hsa00480	0.25691233
90	Huntingtons disease_Homo sapiens_hsa05016	0.25288595
91	African trypanosomiasis_Homo sapiens_hsa05143	0.24112736
92	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.23384596
93	Small cell lung cancer_Homo sapiens_hsa05222	0.19154450
94	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.18857112
95	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.17808317
96	Primary immunodeficiency_Homo sapiens_hsa05340	0.17555600
97	Antigen processing and presentation_Homo sapiens_hsa04612	0.16502174
98	Allograft rejection_Homo sapiens_hsa05330	0.15536490
99	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.10723648
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.09479619

MTX1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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