MTX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is highly similar to the metaxin 2 protein from mouse, which has been shown to interact with the mitochondrial membrane protein metaxin 1. Because of this similarity, it is thought that the encoded protein is peripherally associated with the cytosolic face of the outer mitochondrial membrane, and that it is involved in the import of proteins into the mitochondrion. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.84779197
2ATP synthesis coupled proton transport (GO:0015986)5.29615659
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.29615659
4DNA deamination (GO:0045006)5.19968615
5oxidative phosphorylation (GO:0006119)5.01053419
6respiratory electron transport chain (GO:0022904)4.51144551
7electron transport chain (GO:0022900)4.41565357
8proteasome assembly (GO:0043248)4.29404605
9regulation of mitochondrial translation (GO:0070129)4.23124533
10ribosomal small subunit assembly (GO:0000028)4.20970904
11tricarboxylic acid cycle (GO:0006099)4.12051096
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.09015685
13cullin deneddylation (GO:0010388)3.79362522
14quinone biosynthetic process (GO:1901663)3.77684682
15ubiquinone biosynthetic process (GO:0006744)3.77684682
16viral transcription (GO:0019083)3.71635897
17translational termination (GO:0006415)3.70924243
18deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.63661991
19lysine catabolic process (GO:0006554)3.61576082
20lysine metabolic process (GO:0006553)3.61576082
21deoxyribose phosphate biosynthetic process (GO:0046385)3.54369695
222-deoxyribonucleotide biosynthetic process (GO:0009265)3.54369695
23ubiquinone metabolic process (GO:0006743)3.47906835
24translational elongation (GO:0006414)3.47501645
25chaperone-mediated protein transport (GO:0072321)3.44281017
26branched-chain amino acid catabolic process (GO:0009083)3.43146558
27protein deneddylation (GO:0000338)3.41654797
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.41005912
29nucleobase-containing small molecule interconversion (GO:0015949)3.38666283
30cellular ketone body metabolic process (GO:0046950)3.37382840
31SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.36520196
32telomere maintenance via semi-conservative replication (GO:0032201)3.36506483
33chromatin remodeling at centromere (GO:0031055)3.35110594
34ribosomal large subunit biogenesis (GO:0042273)3.32775327
35DNA damage response, detection of DNA damage (GO:0042769)3.30295311
36DNA strand elongation involved in DNA replication (GO:0006271)3.29362009
37cotranslational protein targeting to membrane (GO:0006613)3.29008628
38folic acid-containing compound biosynthetic process (GO:0009396)3.28414729
39protein targeting to ER (GO:0045047)3.27086863
40establishment of integrated proviral latency (GO:0075713)3.26925609
41heme biosynthetic process (GO:0006783)3.25338438
42deoxyribonucleotide biosynthetic process (GO:0009263)3.23894985
43protein localization to endoplasmic reticulum (GO:0070972)3.22049837
44CENP-A containing nucleosome assembly (GO:0034080)3.21211865
45glyoxylate metabolic process (GO:0046487)3.20014318
46maturation of SSU-rRNA (GO:0030490)3.19782133
47cysteine metabolic process (GO:0006534)3.18518302
48pteridine-containing compound biosynthetic process (GO:0042559)3.17569300
49protein neddylation (GO:0045116)3.15089317
50L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.15083303
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.12422170
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.12422170
53NADH dehydrogenase complex assembly (GO:0010257)3.12422170
54negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.12135954
55DNA double-strand break processing (GO:0000729)3.11222009
56regulation of cellular amino acid metabolic process (GO:0006521)3.10454593
57establishment of protein localization to endoplasmic reticulum (GO:0072599)3.10185913
58aerobic respiration (GO:0009060)3.09878788
59translational initiation (GO:0006413)3.09802231
60DNA strand elongation (GO:0022616)3.07078526
61translation (GO:0006412)3.05908849
62transcription elongation from RNA polymerase III promoter (GO:0006385)3.05460933
63termination of RNA polymerase III transcription (GO:0006386)3.05460933
64folic acid metabolic process (GO:0046655)3.04161363
65ribosomal small subunit biogenesis (GO:0042274)3.03191564
66formation of translation preinitiation complex (GO:0001731)3.01090258
67amino acid salvage (GO:0043102)3.00922779
68L-methionine salvage (GO:0071267)3.00922779
69L-methionine biosynthetic process (GO:0071265)3.00922779
70DNA replication checkpoint (GO:0000076)3.00695975
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.00486393
72L-phenylalanine metabolic process (GO:0006558)3.00486393
73protein complex biogenesis (GO:0070271)2.98563808
74inner mitochondrial membrane organization (GO:0007007)2.96401177
75fatty acid beta-oxidation (GO:0006635)2.96274057
76positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95316250
77ketone body metabolic process (GO:1902224)2.95024832
78pseudouridine synthesis (GO:0001522)2.94636694
79branched-chain amino acid metabolic process (GO:0009081)2.94602373
80purine nucleoside triphosphate biosynthetic process (GO:0009145)2.93469841
81ATP biosynthetic process (GO:0006754)2.91627928
82mitochondrial respiratory chain complex assembly (GO:0033108)2.91422105
83pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.90943326
84purine nucleobase biosynthetic process (GO:0009113)2.90891005
85* protein targeting to mitochondrion (GO:0006626)2.90009652
86viral life cycle (GO:0019058)2.88438099
87telomere maintenance via recombination (GO:0000722)2.87922599
88glycine metabolic process (GO:0006544)2.87885038
89NADH metabolic process (GO:0006734)2.87647459
90nucleoside diphosphate biosynthetic process (GO:0009133)2.87423847
91purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.86916552
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85869950
93ribosome assembly (GO:0042255)2.85800338
94* protein localization to mitochondrion (GO:0070585)2.85718531
95spliceosomal snRNP assembly (GO:0000387)2.85297225
96iron-sulfur cluster assembly (GO:0016226)2.85252458
97metallo-sulfur cluster assembly (GO:0031163)2.85252458
98heme metabolic process (GO:0042168)2.83935175
99* mitochondrial transport (GO:0006839)2.83775125
100* establishment of protein localization to mitochondrion (GO:0072655)2.82939508
101serine family amino acid biosynthetic process (GO:0009070)2.82756884
102IMP biosynthetic process (GO:0006188)2.80876810
103DNA replication initiation (GO:0006270)2.80110034
104protein-cofactor linkage (GO:0018065)2.79283672
105anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.77225899
106cellular respiration (GO:0045333)2.77223832
107cellular protein complex disassembly (GO:0043624)2.76958015
108peptidyl-histidine modification (GO:0018202)2.75262322
109water-soluble vitamin biosynthetic process (GO:0042364)2.74197960
110tricarboxylic acid metabolic process (GO:0072350)2.73429701
111negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72954418
112negative regulation of ligase activity (GO:0051352)2.72954418
113ribonucleoside triphosphate biosynthetic process (GO:0009201)2.72942335
114respiratory chain complex IV assembly (GO:0008535)2.72742946
115histone exchange (GO:0043486)2.72650427
116pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.71833254
117nucleobase biosynthetic process (GO:0046112)2.71769337
118nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.71665561
119valine metabolic process (GO:0006573)2.70739347
120exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.70723755
121GTP biosynthetic process (GO:0006183)2.70426737
122nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69991126
123regulation of mitotic spindle checkpoint (GO:1903504)2.69083019
124regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.69083019
125positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.68222137
126tRNA aminoacylation for protein translation (GO:0006418)2.67454514
127tRNA aminoacylation (GO:0043039)2.66253540
128amino acid activation (GO:0043038)2.66253540
129pyrimidine nucleobase catabolic process (GO:0006208)2.62535387
130ribonucleoprotein complex disassembly (GO:0032988)2.60754967
131positive regulation of mitochondrial fission (GO:0090141)2.59125465
132nonmotile primary cilium assembly (GO:0035058)2.58810549
133organelle disassembly (GO:1903008)2.58300194
134IMP metabolic process (GO:0046040)2.58242397
135positive regulation of ligase activity (GO:0051351)2.55416273
136establishment of viral latency (GO:0019043)2.54180857
137DNA replication-independent nucleosome organization (GO:0034724)2.54063046
138DNA replication-independent nucleosome assembly (GO:0006336)2.54063046
139histone H2A acetylation (GO:0043968)2.53869601
140DNA catabolic process, exonucleolytic (GO:0000738)2.53355933
141de novo protein folding (GO:0006458)2.52925933
142cellular component biogenesis (GO:0044085)2.49315582
143resolution of meiotic recombination intermediates (GO:0000712)2.48391703
144regulation of ubiquitin-protein transferase activity (GO:0051438)2.48304320
145mitotic metaphase plate congression (GO:0007080)2.46594124
146pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.43596570
147de novo posttranslational protein folding (GO:0051084)2.42863901
148regulation of cofactor metabolic process (GO:0051193)2.39254801
149regulation of coenzyme metabolic process (GO:0051196)2.39254801
150synapsis (GO:0007129)2.39202137
151negative regulation of mitotic sister chromatid separation (GO:2000816)2.38766648
152negative regulation of sister chromatid segregation (GO:0033046)2.38766648
153negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.38766648
154negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.38766648
155negative regulation of mitotic sister chromatid segregation (GO:0033048)2.38766648
156pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.38628629
157regulation of ligase activity (GO:0051340)2.38344090
1587-methylguanosine mRNA capping (GO:0006370)2.38152194
159protein K11-linked ubiquitination (GO:0070979)2.37350883
160negative regulation of DNA recombination (GO:0045910)2.36487154
161regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.35745187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.75161234
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.56042630
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.37861518
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.01658371
5E2F7_22180533_ChIP-Seq_HELA_Human3.87746693
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.68252549
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.61469953
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.41810300
9MYC_18358816_ChIP-ChIP_MESCs_Mouse3.12807458
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.09574550
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.06937507
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.96236863
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68215694
14DCP1A_22483619_ChIP-Seq_HELA_Human2.54132429
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51694663
16* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.49733891
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40998359
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33162527
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31478954
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30114546
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30084141
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29916126
23* VDR_23849224_ChIP-Seq_CD4+_Human2.25885905
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24559831
25XRN2_22483619_ChIP-Seq_HELA_Human2.24222767
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23918684
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23795229
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.23450984
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20558617
30SRF_21415370_ChIP-Seq_HL-1_Mouse2.20502252
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16158931
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.14754996
33RXR_22158963_ChIP-Seq_LIVER_Mouse2.05482581
34* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.04337637
35* GABP_19822575_ChIP-Seq_HepG2_Human2.00788255
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96947445
37FOXP3_21729870_ChIP-Seq_TREG_Human1.95994137
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.91656778
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.89536547
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87574456
41* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.86970802
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86799374
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84361318
44AR_21909140_ChIP-Seq_LNCAP_Human1.81559032
45TTF2_22483619_ChIP-Seq_HELA_Human1.80936029
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78290598
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.76909550
48ZNF274_21170338_ChIP-Seq_K562_Hela1.73132883
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72630963
50GATA1_22025678_ChIP-Seq_K562_Human1.71462579
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69828593
52IGF1R_20145208_ChIP-Seq_DFB_Human1.68855097
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65471893
54* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.65056712
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64180048
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64108154
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63537172
58ELK1_19687146_ChIP-ChIP_HELA_Human1.59755219
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59198296
60* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53870365
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47737593
62* FUS_26573619_Chip-Seq_HEK293_Human1.46645858
63VDR_22108803_ChIP-Seq_LS180_Human1.45382385
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42271317
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.39009508
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.38879252
67* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38102401
68* EWS_26573619_Chip-Seq_HEK293_Human1.37515598
69* E2F1_21310950_ChIP-Seq_MCF-7_Human1.36876703
70* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.36103597
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.30752050
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28783046
73* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27666909
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27637002
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.23805928
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23171318
77ZNF263_19887448_ChIP-Seq_K562_Human1.23123279
78TAF15_26573619_Chip-Seq_HEK293_Human1.22579489
79FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20960266
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.19525208
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19362756
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19234799
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18047235
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17913592
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17714698
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17232773
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11871855
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.11546887
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10233196
90ELK1_22589737_ChIP-Seq_MCF10A_Human1.09746700
91* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.09053773
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08500815
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07044389
94LXR_22158963_ChIP-Seq_LIVER_Mouse1.07019994
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06728693
96* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05816200
97* MYC_18940864_ChIP-ChIP_HL60_Human1.03582944
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.03076462
99PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02075884
100TFEB_21752829_ChIP-Seq_HELA_Human1.01886044
101SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01125609
102CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00770281
103IRF1_19129219_ChIP-ChIP_H3396_Human1.00523975
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00176263
105CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99188702
106KDM5A_27292631_Chip-Seq_BREAST_Human0.98237974
107* RNF2_27304074_Chip-Seq_NSC_Mouse0.97898728
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96574195
109CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95946895
110FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94224525
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93705730
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92703060
113REST_19997604_ChIP-ChIP_NEURONS_Mouse0.91928157
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90834335
115MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89987453
116CIITA_25753668_ChIP-Seq_RAJI_Human0.89980744
117SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89424637
118* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89256548
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88563904
120GBX2_23144817_ChIP-Seq_PC3_Human0.88430477
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88345352
122CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87167529
123SOX17_20123909_ChIP-Seq_XEN_Mouse0.87101567
124* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85700902
125FOXM1_23109430_ChIP-Seq_U2OS_Human0.84833751
126P300_19829295_ChIP-Seq_ESCs_Human0.83567988
127HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.82805983
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82567969
129GATA4_21415370_ChIP-Seq_HL-1_Mouse0.82297494
130TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79733180
131CTBP1_25329375_ChIP-Seq_LNCAP_Human0.78961818
132CLOCK_20551151_ChIP-Seq_293T_Human0.78893647
133* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78064286
134* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.76950561
135TP53_22573176_ChIP-Seq_HFKS_Human0.76303154

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.68165668
2MP0002139_abnormal_hepatobiliary_system4.33093552
3MP0005360_urolithiasis3.95696729
4MP0005085_abnormal_gallbladder_physiolo3.59754627
5MP0006036_abnormal_mitochondrial_physio3.31987376
6MP0005365_abnormal_bile_salt3.16456233
7MP0003186_abnormal_redox_activity3.01692509
8MP0004147_increased_porphyrin_level2.88287813
9MP0004215_abnormal_myocardial_fiber2.59200789
10MP0003693_abnormal_embryo_hatching2.58627561
11MP0008789_abnormal_olfactory_epithelium2.58444139
12MP0003646_muscle_fatigue2.54457719
13MP0004084_abnormal_cardiac_muscle2.53414664
14MP0003656_abnormal_erythrocyte_physiolo2.50440387
15MP0003195_calcinosis2.44191878
16MP0009379_abnormal_foot_pigmentation2.42309087
17MP0009840_abnormal_foam_cell2.38284693
18MP0003122_maternal_imprinting2.36040051
19MP0003221_abnormal_cardiomyocyte_apopto2.33384464
20MP0005499_abnormal_olfactory_system2.29092596
21MP0005394_taste/olfaction_phenotype2.29092596
22MP0006035_abnormal_mitochondrial_morpho2.26069916
23MP0008875_abnormal_xenobiotic_pharmacok2.21652564
24MP0004957_abnormal_blastocyst_morpholog2.20017677
25MP0005332_abnormal_amino_acid2.15576535
26MP0008877_abnormal_DNA_methylation2.15148918
27MP0005083_abnormal_biliary_tract2.15077089
28MP0002822_catalepsy2.14480110
29MP0002102_abnormal_ear_morphology2.06754863
30MP0003121_genomic_imprinting2.05236212
31MP0005084_abnormal_gallbladder_morpholo1.97503216
32MP0005330_cardiomyopathy1.87185162
33MP0002837_dystrophic_cardiac_calcinosis1.86493634
34MP0003941_abnormal_skin_development1.85401205
35MP0008775_abnormal_heart_ventricle1.78061362
36MP0003567_abnormal_fetal_cardiomyocyte1.75403416
37MP0006292_abnormal_olfactory_placode1.71688209
38MP0001984_abnormal_olfaction1.71301650
39MP0010329_abnormal_lipoprotein_level1.70973988
40MP0009046_muscle_twitch1.69214383
41MP0001666_abnormal_nutrient_absorption1.65980972
42MP0001764_abnormal_homeostasis1.64881934
43MP0005319_abnormal_enzyme/_coenzyme1.64730117
44MP0003786_premature_aging1.63817077
45MP0003252_abnormal_bile_duct1.63102336
46MP0003880_abnormal_central_pattern1.62715034
47MP0001188_hyperpigmentation1.59929891
48MP0003890_abnormal_embryonic-extraembry1.57281226
49MP0008995_early_reproductive_senescence1.57096181
50MP0006072_abnormal_retinal_apoptosis1.56352798
51MP0004036_abnormal_muscle_relaxation1.52667267
52MP0006276_abnormal_autonomic_nervous1.49593362
53MP0005670_abnormal_white_adipose1.49095924
54MP0010094_abnormal_chromosome_stability1.48607685
55MP0003123_paternal_imprinting1.47964302
56MP0005584_abnormal_enzyme/coenzyme_acti1.46522800
57MP0009697_abnormal_copulation1.45356115
58MP0006054_spinal_hemorrhage1.43695780
59MP0001293_anophthalmia1.43357328
60MP0003111_abnormal_nucleus_morphology1.39396690
61MP0003077_abnormal_cell_cycle1.39273347
62MP0005636_abnormal_mineral_homeostasis1.35639189
63MP0005266_abnormal_metabolism1.33979401
64MP0000609_abnormal_liver_physiology1.33886588
65MP0004130_abnormal_muscle_cell1.32026718
66MP0000358_abnormal_cell_content/1.30265858
67MP0004270_analgesia1.29632247
68MP0003937_abnormal_limbs/digits/tail_de1.29379225
69MP0004145_abnormal_muscle_electrophysio1.29373453
70MP0008932_abnormal_embryonic_tissue1.27984225
71MP0003787_abnormal_imprinting1.27806313
72MP0009643_abnormal_urine_homeostasis1.22785294
73MP0001544_abnormal_cardiovascular_syste1.21649693
74MP0005385_cardiovascular_system_phenoty1.21649693
75MP0000749_muscle_degeneration1.18447619
76MP0002118_abnormal_lipid_homeostasis1.16959714
77MP0002160_abnormal_reproductive_system1.16225636
78MP0001853_heart_inflammation1.15018866
79MP0002233_abnormal_nose_morphology1.13820012
80MP0002272_abnormal_nervous_system1.13495083
81MP0004142_abnormal_muscle_tone1.11642193
82MP0004133_heterotaxia1.11399963
83MP0006138_congestive_heart_failure1.08642337
84MP0002210_abnormal_sex_determination1.08164744
85MP0002972_abnormal_cardiac_muscle1.07782626
86MP0005645_abnormal_hypothalamus_physiol1.07635166
87MP0005666_abnormal_adipose_tissue1.07620723
88MP0003136_yellow_coat_color1.07232551
89MP0002184_abnormal_innervation1.05586830
90MP0008058_abnormal_DNA_repair1.05566468
91MP0003119_abnormal_digestive_system1.04152001
92MP0002138_abnormal_hepatobiliary_system1.04080302
93MP0010386_abnormal_urinary_bladder1.03733231
94MP0003011_delayed_dark_adaptation1.03391333
95MP0005220_abnormal_exocrine_pancreas1.03230197
96MP0002736_abnormal_nociception_after1.02071695
97MP0003137_abnormal_impulse_conducting1.01996882
98MP0003718_maternal_effect1.01994404
99MP0000598_abnormal_liver_morphology1.01979598
100MP0003191_abnormal_cellular_cholesterol1.01915821
101MP0004859_abnormal_synaptic_plasticity1.01449743
102MP0004019_abnormal_vitamin_homeostasis1.00595243
103MP0000778_abnormal_nervous_system1.00063352
104MP0004043_abnormal_pH_regulation0.99011268
105MP0000631_abnormal_neuroendocrine_gland0.97982687
106MP0000490_abnormal_crypts_of0.97909951
107MP0001929_abnormal_gametogenesis0.94733739
108MP0002751_abnormal_autonomic_nervous0.94686722
109MP0002734_abnormal_mechanical_nocicepti0.94187905
110MP0000049_abnormal_middle_ear0.92339543
111MP0002269_muscular_atrophy0.92022681
112MP0002971_abnormal_brown_adipose0.91272158
113MP0003315_abnormal_perineum_morphology0.91099149
114MP0000647_abnormal_sebaceous_gland0.90684418
115MP0005376_homeostasis/metabolism_phenot0.89718559
116MP0009745_abnormal_behavioral_response0.89324271
117MP0001299_abnormal_eye_distance/0.89196213
118MP0005165_increased_susceptibility_to0.89152188
119MP0000955_abnormal_spinal_cord0.88116434
120MP0002638_abnormal_pupillary_reflex0.87420415
121MP0004484_altered_response_of0.86279758
122MP0000750_abnormal_muscle_regeneration0.85913701
123MP0003698_abnormal_male_reproductive0.85516452
124MP0005253_abnormal_eye_physiology0.85230609
125MP0004233_abnormal_muscle_weight0.85122982
126MP0005551_abnormal_eye_electrophysiolog0.84570291
127MP0001145_abnormal_male_reproductive0.84426640
128MP0000343_altered_response_to0.83678745
129MP0002090_abnormal_vision0.83643925
130MP0001905_abnormal_dopamine_level0.82463273
131MP0008469_abnormal_protein_level0.82253715
132MP0008007_abnormal_cellular_replicative0.81764450
133MP0005535_abnormal_body_temperature0.81343404
134MP0005423_abnormal_somatic_nervous0.81075557
135MP0000653_abnormal_sex_gland0.80742327
136MP0001529_abnormal_vocalization0.80211055
137MP0001661_extended_life_span0.79752602
138MP0003868_abnormal_feces_composition0.79742153
139MP0001730_embryonic_growth_arrest0.79732630
140MP0002396_abnormal_hematopoietic_system0.78734777
141MP0002735_abnormal_chemical_nociception0.78402706
142MP0003385_abnormal_body_wall0.78217687
143MP0010630_abnormal_cardiac_muscle0.77760472
144MP0002653_abnormal_ependyma_morphology0.77706311
145MP0002697_abnormal_eye_size0.77558804
146MP0004811_abnormal_neuron_physiology0.77533719
147MP0005620_abnormal_muscle_contractility0.77277597
148MP0002078_abnormal_glucose_homeostasis0.76806010
149MP0001324_abnormal_eye_pigmentation0.76553726
150MP0003635_abnormal_synaptic_transmissio0.75888858
151MP0002084_abnormal_developmental_patter0.75604559
152MP0001727_abnormal_embryo_implantation0.74930371
153MP0002234_abnormal_pharynx_morphology0.74766007
154MP0002752_abnormal_somatic_nervous0.74381739
155MP0002085_abnormal_embryonic_tissue0.74093175
156MP0009763_increased_sensitivity_to0.73841183
157MP0004087_abnormal_muscle_fiber0.73765078
158MP0000751_myopathy0.73084670
159MP0002557_abnormal_social/conspecific_i0.71521581
160MP0001968_abnormal_touch/_nociception0.71504760
161MP0003724_increased_susceptibility_to0.69026101
162MP0009642_abnormal_blood_homeostasis0.68860515
163MP0002332_abnormal_exercise_endurance0.67091986
164MP0001756_abnormal_urination0.66443637
165MP0002938_white_spotting0.66192306
166MP0005187_abnormal_penis_morphology0.65174913
167MP0002970_abnormal_white_adipose0.64486169
168MP0000372_irregular_coat_pigmentation0.63844623
169MP0002106_abnormal_muscle_physiology0.62930483
170MP0002127_abnormal_cardiovascular_syste0.60193216

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.89255663
2Hepatic necrosis (HP:0002605)4.87261115
3Abnormal mitochondria in muscle tissue (HP:0008316)4.82340250
4Acute encephalopathy (HP:0006846)4.65182025
5Abnormality of alanine metabolism (HP:0010916)4.51490808
6Hyperalaninemia (HP:0003348)4.51490808
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.51490808
8Hepatocellular necrosis (HP:0001404)4.35978993
9Mitochondrial inheritance (HP:0001427)4.34839769
10Cerebral edema (HP:0002181)4.34652649
11Increased CSF lactate (HP:0002490)4.25899844
12Hypoglycemic coma (HP:0001325)4.10089402
13Progressive macrocephaly (HP:0004481)3.95308787
14Lipid accumulation in hepatocytes (HP:0006561)3.92433417
15Abnormality of dicarboxylic acid metabolism (HP:0010995)3.91568979
16Dicarboxylic aciduria (HP:0003215)3.91568979
17Nausea (HP:0002018)3.89128502
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.87938361
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.87938361
20Lactic acidosis (HP:0003128)3.87174489
21Increased muscle lipid content (HP:0009058)3.83439938
22Abnormality of aromatic amino acid family metabolism (HP:0004338)3.76459029
23Increased serum lactate (HP:0002151)3.72340162
24Abnormality of fatty-acid metabolism (HP:0004359)3.64074391
25Increased intramyocellular lipid droplets (HP:0012240)3.62668369
26Hyperammonemia (HP:0001987)3.60791748
27Increased hepatocellular lipid droplets (HP:0006565)3.52316624
28Abnormality of the heme biosynthetic pathway (HP:0010472)3.43734906
29Abnormality of glycolysis (HP:0004366)3.36077713
30Increased serum pyruvate (HP:0003542)3.36077713
31Abnormal number of erythroid precursors (HP:0012131)3.32187055
32Abnormality of cells of the erythroid lineage (HP:0012130)3.31621321
33Lethargy (HP:0001254)3.31520603
34Generalized aminoaciduria (HP:0002909)3.30587578
35Ketoacidosis (HP:0001993)3.28744402
36Ketosis (HP:0001946)3.28047388
373-Methylglutaconic aciduria (HP:0003535)3.12392583
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.10676678
39Exercise intolerance (HP:0003546)3.09349184
40Abnormality of serum amino acid levels (HP:0003112)3.07305184
41Respiratory failure (HP:0002878)3.06392646
42Myoglobinuria (HP:0002913)3.01253882
43Rhabdomyolysis (HP:0003201)2.94444952
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.92766725
45Proximal tubulopathy (HP:0000114)2.91642088
46Hypobetalipoproteinemia (HP:0003563)2.83809511
47Hyperglycinemia (HP:0002154)2.83213437
48Hyperglycinuria (HP:0003108)2.79332230
49Abnormality of the labia minora (HP:0012880)2.78809908
50Ragged-red muscle fibers (HP:0003200)2.72941817
51Multiple enchondromatosis (HP:0005701)2.71331800
52Abnormality of serine family amino acid metabolism (HP:0010894)2.70043364
53Abnormality of glycine metabolism (HP:0010895)2.70043364
54Abnormality of urine glucose concentration (HP:0011016)2.64339264
55Glycosuria (HP:0003076)2.64339264
56Palpitations (HP:0001962)2.63453872
57Methylmalonic aciduria (HP:0012120)2.63123203
58Renal Fanconi syndrome (HP:0001994)2.60013679
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.56543629
60Intrahepatic cholestasis (HP:0001406)2.54752872
61Vomiting (HP:0002013)2.54009633
62Metabolic acidosis (HP:0001942)2.51390190
63CNS demyelination (HP:0007305)2.48208164
64Oral leukoplakia (HP:0002745)2.45891241
65Cortical dysplasia (HP:0002539)2.44405703
66Microretrognathia (HP:0000308)2.43784447
67Macrocytic anemia (HP:0001972)2.43612569
68Xanthomatosis (HP:0000991)2.42539329
69Abnormality of the anterior horn cell (HP:0006802)2.41678874
70Degeneration of anterior horn cells (HP:0002398)2.41678874
71Aplastic anemia (HP:0001915)2.40434040
72Hyperlipoproteinemia (HP:0010980)2.40372920
73Reticulocytopenia (HP:0001896)2.37408541
74Prolonged partial thromboplastin time (HP:0003645)2.35898596
75Abnormality of monocarboxylic acid metabolism (HP:0010996)2.34838131
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.31989089
77Medial flaring of the eyebrow (HP:0010747)2.31518173
78Gait imbalance (HP:0002141)2.28081982
79Delayed CNS myelination (HP:0002188)2.26559031
80Congenital primary aphakia (HP:0007707)2.22647370
81Neoplasm of the adrenal gland (HP:0100631)2.22102145
82Aplasia/Hypoplasia of the sacrum (HP:0008517)2.21485676
83Neuroendocrine neoplasm (HP:0100634)2.20459523
84Abnormality of methionine metabolism (HP:0010901)2.19339657
85Retinal dysplasia (HP:0007973)2.16791177
86Hypolipoproteinemia (HP:0010981)2.16244304
87Optic disc pallor (HP:0000543)2.15270202
88True hermaphroditism (HP:0010459)2.14286969
89Pancreatic cysts (HP:0001737)2.13662355
90Reduced antithrombin III activity (HP:0001976)2.13565787
91Hyperbilirubinemia (HP:0002904)2.13038211
92Respiratory difficulties (HP:0002880)2.11940094
93Nephrogenic diabetes insipidus (HP:0009806)2.11231732
94Progressive muscle weakness (HP:0003323)2.08682627
95Cerebral hypomyelination (HP:0006808)2.07792644
96Exertional dyspnea (HP:0002875)2.07523687
97Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.07515639
98Emotional lability (HP:0000712)2.07394665
99Brushfield spots (HP:0001088)2.03417828
100Conjunctival hamartoma (HP:0100780)2.02357388
101Hyperphosphaturia (HP:0003109)2.02056866
102Abnormal lung lobation (HP:0002101)2.01110384
103Late onset (HP:0003584)2.00661164
104Gliosis (HP:0002171)2.00230399
105Pallor (HP:0000980)2.00086822
106Exercise-induced muscle cramps (HP:0003710)1.99984727
107Colon cancer (HP:0003003)1.95559424
108Megaloblastic anemia (HP:0001889)1.95312985
109Myokymia (HP:0002411)1.94824652
110Leukodystrophy (HP:0002415)1.93752090
111Renal cortical cysts (HP:0000803)1.92188030
112CNS hypomyelination (HP:0003429)1.90423631
113Poor suck (HP:0002033)1.88847907
114Molar tooth sign on MRI (HP:0002419)1.88551781
115Abnormality of midbrain morphology (HP:0002418)1.88551781
116Pheochromocytoma (HP:0002666)1.87080086
117Pancreatic fibrosis (HP:0100732)1.86307800
118Methylmalonic acidemia (HP:0002912)1.86253847
119Degeneration of the lateral corticospinal tracts (HP:0002314)1.86158881
120Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86158881
121Microvesicular hepatic steatosis (HP:0001414)1.84548604
122Nephronophthisis (HP:0000090)1.82235849
123Abnormality of pyrimidine metabolism (HP:0004353)1.79830207
124Increased serum ferritin (HP:0003281)1.75424347
125Aplasia/hypoplasia of the uterus (HP:0008684)1.74949638
126Type II lissencephaly (HP:0007260)1.72795947
127Genital tract atresia (HP:0001827)1.72689477
128Vaginal atresia (HP:0000148)1.72153714
129Sclerocornea (HP:0000647)1.69458298
130Ependymoma (HP:0002888)1.68304460
131X-linked dominant inheritance (HP:0001423)1.66958380
132Type I transferrin isoform profile (HP:0003642)1.64845379
133Polyphagia (HP:0002591)1.64544778
134Hypoplasia of the uterus (HP:0000013)1.61576171
135Abnormality of the corticospinal tract (HP:0002492)1.61177718
136Abnormality of renal resorption (HP:0011038)1.60860275
137Anencephaly (HP:0002323)1.60810844
138Postnatal microcephaly (HP:0005484)1.60773473
139Gout (HP:0001997)1.59903042
140Horseshoe kidney (HP:0000085)1.59048470
141Occipital encephalocele (HP:0002085)1.58655936
142Upper limb muscle weakness (HP:0003484)1.57940585
143Lissencephaly (HP:0001339)1.57417576
144Abnormal respiratory epithelium morphology (HP:0012253)1.54226192
145Abnormal respiratory motile cilium morphology (HP:0005938)1.54226192
146Meckel diverticulum (HP:0002245)1.53300187

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.98257205
2STK164.71116312
3NME24.68300102
4WEE13.61968591
5EIF2AK13.44436869
6BUB13.37129476
7ACVR1B2.89009488
8TRIM282.70042887
9NEK12.56947789
10MAP3K42.54092624
11BCR2.41737460
12MAP4K22.35689675
13EIF2AK32.33392503
14SCYL22.26160614
15MAP2K72.23939446
16NME11.97516278
17KDR1.91118300
18VRK11.88099589
19DYRK31.84457502
20PDK41.76930975
21PDK31.76930975
22MST41.73417737
23FLT31.72532134
24MKNK21.58607217
25CDC71.55025419
26TLK11.43205721
27CSNK1G21.41712366
28PIM21.41011647
29BRSK21.40946222
30MARK11.38925256
31CSNK1G11.38004932
32MINK11.31147995
33ABL21.30143862
34ERBB31.27636813
35RPS6KA41.19827974
36CSNK1A1L1.18098621
37TGFBR11.17503158
38VRK21.17110615
39MAP3K121.15714474
40OBSCN1.14896353
41PLK41.12205389
42BMPR1B1.09730714
43PKN21.09564108
44CASK1.08777821
45MAP3K111.06792980
46NEK21.06393123
47SRPK11.06231924
48MAPK131.06008457
49PINK11.04544536
50AURKA1.04034279
51WNK31.02785451
52PLK21.02753614
53AURKB1.02520990
54ZAK1.01618723
55TESK20.99596072
56PBK0.97433651
57ARAF0.93678226
58PLK10.93303420
59EPHA40.90038055
60LMTK20.87715695
61LIMK10.86201018
62CDK80.84349276
63PASK0.84020222
64RPS6KB20.83488979
65EIF2AK20.81645436
66MAP3K50.78378302
67PDK20.77387200
68TTK0.75958761
69PRKCG0.73830769
70TESK10.73178273
71PIK3CG0.72408922
72CDK40.70839727
73BRAF0.70818120
74MAPKAPK30.69744028
75CSNK2A10.68122768
76CDK140.66398836
77DYRK20.66333577
78MYLK0.65663928
79ERBB40.65141339
80TEC0.64443909
81ILK0.64002523
82EPHA20.62713144
83LRRK20.62255267
84WNK40.60697750
85TAOK20.60282318
86PNCK0.60071195
87RAF10.59873468
88CSNK2A20.59635761
89CDK70.59512977
90CSNK1E0.59274854
91CAMKK20.59260323
92BRSK10.58145850
93MKNK10.57943584
94UHMK10.57822959
95CCNB10.57799767
96KIT0.57196653
97NUAK10.55881458
98CAMK2A0.54884887
99TYK20.54421487
100STK38L0.54110468
101ADRBK20.53000001
102CDK180.52656050
103ATR0.51684912
104PHKG20.51654857
105PHKG10.51654857
106NEK90.51411498
107ATM0.51324736
108TIE10.49320576
109MAPK110.48788594
110MAP2K40.48724214
111TNIK0.48523661
112CDK11A0.48270525
113CHEK10.48144964
114CDK30.48059023
115RPS6KA50.47360180
116CLK10.47035419
117MAP3K80.46801880
118KSR10.45781582
119CHEK20.45744149
120CDK150.45332269
121DYRK1A0.45090233
122GRK10.44492770
123MOS0.43963361
124GRK70.41889803
125PRKCE0.40670016
126INSRR0.40662720
127ERN10.40550904
128CAMK2G0.39974980
129AKT20.39907029
130CAMK2D0.39657489
131CDK190.39247071
132CAMK2B0.38928381
133IRAK10.38672480
134MAPKAPK50.38538820
135DAPK10.38535775
136CSNK1A10.38434071
137PLK30.37614413
138TGFBR20.37020527
139MAP2K10.36858886
140TSSK60.36357223
141CDK10.36111515
142MAP3K30.35967414
143OXSR10.35160536
144MAP2K30.35018011
145TBK10.33665605
146IRAK30.29849768
147CSNK1G30.29693310
148DAPK30.28755637

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.37901918
2Ribosome_Homo sapiens_hsa030103.00309552
3Oxidative phosphorylation_Homo sapiens_hsa001902.88019571
4Proteasome_Homo sapiens_hsa030502.87674775
5Parkinsons disease_Homo sapiens_hsa050122.85893618
6DNA replication_Homo sapiens_hsa030302.74769330
7Propanoate metabolism_Homo sapiens_hsa006402.66288248
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43166169
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.38331242
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.31807680
11Fatty acid degradation_Homo sapiens_hsa000712.23524051
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.18030561
13Folate biosynthesis_Homo sapiens_hsa007902.06434053
14Carbon metabolism_Homo sapiens_hsa012002.03794984
15Huntingtons disease_Homo sapiens_hsa050161.97653089
16Mismatch repair_Homo sapiens_hsa034301.96345708
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94473140
18Pyrimidine metabolism_Homo sapiens_hsa002401.88655830
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.86910590
20Pyruvate metabolism_Homo sapiens_hsa006201.86302181
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.83726116
22Alzheimers disease_Homo sapiens_hsa050101.82846176
23RNA polymerase_Homo sapiens_hsa030201.67596590
24Sulfur relay system_Homo sapiens_hsa041221.65543830
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.63818597
26One carbon pool by folate_Homo sapiens_hsa006701.62860019
27Peroxisome_Homo sapiens_hsa041461.60727708
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.56965591
29Butanoate metabolism_Homo sapiens_hsa006501.54624021
30Biosynthesis of amino acids_Homo sapiens_hsa012301.49674327
31Fatty acid metabolism_Homo sapiens_hsa012121.47753822
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.46972599
33Nucleotide excision repair_Homo sapiens_hsa034201.44962730
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37899136
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35569295
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.32941680
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32312027
38Selenocompound metabolism_Homo sapiens_hsa004501.30745862
39Tryptophan metabolism_Homo sapiens_hsa003801.29721568
40Base excision repair_Homo sapiens_hsa034101.28019750
41Protein export_Homo sapiens_hsa030601.25928090
42Sulfur metabolism_Homo sapiens_hsa009201.25424894
43beta-Alanine metabolism_Homo sapiens_hsa004101.22702574
44Cardiac muscle contraction_Homo sapiens_hsa042601.21411330
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18601363
46Nicotine addiction_Homo sapiens_hsa050331.16977067
47Pentose phosphate pathway_Homo sapiens_hsa000301.16211813
48Spliceosome_Homo sapiens_hsa030401.13741236
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13691785
50Fatty acid elongation_Homo sapiens_hsa000621.13170057
51Homologous recombination_Homo sapiens_hsa034401.13154474
52Caffeine metabolism_Homo sapiens_hsa002321.09645294
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09216823
54PPAR signaling pathway_Homo sapiens_hsa033201.07944976
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06796008
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04575603
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03152148
58Glutathione metabolism_Homo sapiens_hsa004801.01261665
59RNA transport_Homo sapiens_hsa030130.99363676
60Metabolic pathways_Homo sapiens_hsa011000.91047486
61Oocyte meiosis_Homo sapiens_hsa041140.87666623
62Arginine biosynthesis_Homo sapiens_hsa002200.87226809
63Purine metabolism_Homo sapiens_hsa002300.86995503
64Phototransduction_Homo sapiens_hsa047440.82188133
65Arginine and proline metabolism_Homo sapiens_hsa003300.80497006
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78821606
67Starch and sucrose metabolism_Homo sapiens_hsa005000.77530139
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72529013
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.72138542
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72088540
71Synaptic vesicle cycle_Homo sapiens_hsa047210.71896369
72Fat digestion and absorption_Homo sapiens_hsa049750.71061184
73mRNA surveillance pathway_Homo sapiens_hsa030150.67393744
74Galactose metabolism_Homo sapiens_hsa000520.65651125
75Regulation of autophagy_Homo sapiens_hsa041400.65593008
76Tyrosine metabolism_Homo sapiens_hsa003500.64558268
77Phenylalanine metabolism_Homo sapiens_hsa003600.63449740
78RNA degradation_Homo sapiens_hsa030180.63291230
79GABAergic synapse_Homo sapiens_hsa047270.63072679
80Histidine metabolism_Homo sapiens_hsa003400.61978674
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.61022081
82Chemical carcinogenesis_Homo sapiens_hsa052040.60761234
83Cell cycle_Homo sapiens_hsa041100.59279274
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59026730
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56489308
86Retinol metabolism_Homo sapiens_hsa008300.55850488
87Systemic lupus erythematosus_Homo sapiens_hsa053220.54853462
88Nitrogen metabolism_Homo sapiens_hsa009100.53308030
89Collecting duct acid secretion_Homo sapiens_hsa049660.51314247
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51173424
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50753943
92Fructose and mannose metabolism_Homo sapiens_hsa000510.49877361
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48197701
94Complement and coagulation cascades_Homo sapiens_hsa046100.46493884
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.45003730
96Basal transcription factors_Homo sapiens_hsa030220.40774795
97Vibrio cholerae infection_Homo sapiens_hsa051100.38518209
98Fanconi anemia pathway_Homo sapiens_hsa034600.38369424
99p53 signaling pathway_Homo sapiens_hsa041150.37436426
100Steroid biosynthesis_Homo sapiens_hsa001000.36763367
101Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33408083
102Olfactory transduction_Homo sapiens_hsa047400.31967910
103N-Glycan biosynthesis_Homo sapiens_hsa005100.31348727
104Taste transduction_Homo sapiens_hsa047420.29871749
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28479666
106Vitamin digestion and absorption_Homo sapiens_hsa049770.27966378
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24914780
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24247251
109Morphine addiction_Homo sapiens_hsa050320.21727844
110Legionellosis_Homo sapiens_hsa051340.21689961
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21454345
112Glycerolipid metabolism_Homo sapiens_hsa005610.20709444
113Alcoholism_Homo sapiens_hsa050340.20506824
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19846946
115Non-homologous end-joining_Homo sapiens_hsa034500.18900796
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11665826
117Vitamin B6 metabolism_Homo sapiens_hsa007500.10053579
118Bile secretion_Homo sapiens_hsa049760.09990877

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