MTX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.29888270
2synaptic vesicle maturation (GO:0016188)4.98623435
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.95685236
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.45215160
5vocalization behavior (GO:0071625)4.42614751
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.39016337
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.23743072
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.22535301
9regulation of glutamate receptor signaling pathway (GO:1900449)4.07691888
10glutamate secretion (GO:0014047)4.05769923
11regulation of synaptic vesicle exocytosis (GO:2000300)4.00042388
12neurotransmitter secretion (GO:0007269)3.97761850
13mitotic sister chromatid cohesion (GO:0007064)3.94513914
14synaptic vesicle exocytosis (GO:0016079)3.84284377
15cellular potassium ion homeostasis (GO:0030007)3.82038676
16regulation of synapse structural plasticity (GO:0051823)3.80284589
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.78479796
18ionotropic glutamate receptor signaling pathway (GO:0035235)3.76567406
19proline transport (GO:0015824)3.75168439
20gamma-aminobutyric acid transport (GO:0015812)3.70314352
21exploration behavior (GO:0035640)3.65921952
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.59384996
23cerebellar Purkinje cell differentiation (GO:0021702)3.51670467
24layer formation in cerebral cortex (GO:0021819)3.49404543
25regulation of neuronal synaptic plasticity (GO:0048168)3.46545637
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.46375809
27nuclear pore complex assembly (GO:0051292)3.44644185
28regulation of synaptic vesicle transport (GO:1902803)3.40465320
29dendrite morphogenesis (GO:0048813)3.34433110
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.29227558
31nuclear pore organization (GO:0006999)3.27117656
32synaptic transmission, glutamatergic (GO:0035249)3.26305608
33sodium ion export (GO:0071436)3.25645410
34neurotransmitter-gated ion channel clustering (GO:0072578)3.24905959
35non-recombinational repair (GO:0000726)3.24823641
36double-strand break repair via nonhomologous end joining (GO:0006303)3.24823641
37glycine transport (GO:0015816)3.24461973
38DNA double-strand break processing (GO:0000729)3.23995185
39activation of protein kinase A activity (GO:0034199)3.23618372
40prepulse inhibition (GO:0060134)3.23148361
41glutamate receptor signaling pathway (GO:0007215)3.22437190
42regulation of centriole replication (GO:0046599)3.21739181
43vesicle transport along microtubule (GO:0047496)3.20308874
44protein localization to synapse (GO:0035418)3.18808923
45pre-miRNA processing (GO:0031054)3.18042427
46dendritic spine morphogenesis (GO:0060997)3.17219224
47establishment of nucleus localization (GO:0040023)3.12792243
48neuron-neuron synaptic transmission (GO:0007270)3.12715211
49neuronal action potential propagation (GO:0019227)3.12392768
50cell communication by electrical coupling (GO:0010644)3.09940527
51alanine transport (GO:0032328)3.08189830
52neurotransmitter transport (GO:0006836)3.07339705
53long-term memory (GO:0007616)3.07131868
54regulation of DNA endoreduplication (GO:0032875)3.06055810
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.02604876
56neuromuscular process controlling posture (GO:0050884)3.02357392
57regulation of growth hormone secretion (GO:0060123)3.01804822
58regulation of excitatory postsynaptic membrane potential (GO:0060079)3.01634393
59synaptic vesicle endocytosis (GO:0048488)3.00243366
60neuromuscular process controlling balance (GO:0050885)2.99621922
61regulation of neurotransmitter levels (GO:0001505)2.98650223
62chromatin remodeling at centromere (GO:0031055)2.98200790
63protein localization to kinetochore (GO:0034501)2.96244692
64negative regulation of DNA-dependent DNA replication (GO:2000104)2.92059835
65positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91316235
66regulation of postsynaptic membrane potential (GO:0060078)2.90355601
67negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.90328979
68neuronal ion channel clustering (GO:0045161)2.89041198
69membrane depolarization during action potential (GO:0086010)2.87039266
70potassium ion import (GO:0010107)2.85658368
71positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.82546923
72regulation of synaptic transmission, glutamatergic (GO:0051966)2.82416744
73neuron cell-cell adhesion (GO:0007158)2.81904795
74sister chromatid segregation (GO:0000819)2.81887077
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.80586879
76negative regulation of translation, ncRNA-mediated (GO:0040033)2.79453973
77regulation of translation, ncRNA-mediated (GO:0045974)2.79453973
78negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79453973
79CENP-A containing nucleosome assembly (GO:0034080)2.78415182
80cerebellar granule cell differentiation (GO:0021707)2.78385137
81regulation of synaptic plasticity (GO:0048167)2.75107878
82dicarboxylic acid biosynthetic process (GO:0043650)2.73901571
83response to X-ray (GO:0010165)2.73329955
84auditory behavior (GO:0031223)2.73301107
85cytoplasmic mRNA processing body assembly (GO:0033962)2.73087129
86negative regulation of DNA recombination (GO:0045910)2.72617445
87histone exchange (GO:0043486)2.70769570
88response to auditory stimulus (GO:0010996)2.70684202
89regulation of dendritic spine morphogenesis (GO:0061001)2.70641517
90regulation of non-canonical Wnt signaling pathway (GO:2000050)2.70398222
91neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.69668339
92regulation of neurotransmitter secretion (GO:0046928)2.69427726
93organelle transport along microtubule (GO:0072384)2.68810868
94regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.68467414
95regulation of mitotic spindle checkpoint (GO:1903504)2.68467414
96L-amino acid import (GO:0043092)2.67316683
97DNA damage response, detection of DNA damage (GO:0042769)2.67094697
98regulation of clathrin-mediated endocytosis (GO:2000369)2.65549795
99positive regulation of potassium ion transmembrane transport (GO:1901381)2.65234753
100metaphase plate congression (GO:0051310)2.64837468
101replication fork processing (GO:0031297)2.64652062
102long-term synaptic potentiation (GO:0060291)2.63914301
103mitotic sister chromatid segregation (GO:0000070)2.63777719
104membrane hyperpolarization (GO:0060081)2.62956435
105regulation of spindle organization (GO:0090224)2.62042073
106dorsal/ventral axis specification (GO:0009950)2.61133393
107positive regulation of membrane potential (GO:0045838)2.60486515
108axonal fasciculation (GO:0007413)2.60353399
109innervation (GO:0060384)2.59684437
110transmission of nerve impulse (GO:0019226)2.59414296
111paraxial mesoderm development (GO:0048339)2.58865397
112suckling behavior (GO:0001967)2.57434247
113anterior/posterior axis specification, embryo (GO:0008595)2.57265377
114regulation of posttranscriptional gene silencing (GO:0060147)2.56586008
115regulation of gene silencing by miRNA (GO:0060964)2.56586008
116regulation of gene silencing by RNA (GO:0060966)2.56586008
117membrane depolarization (GO:0051899)2.56534461
118DNA ligation (GO:0006266)2.56388138
119monoubiquitinated protein deubiquitination (GO:0035520)2.55227535
120regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.55065967
121regulation of neurotransmitter transport (GO:0051588)2.54897095
122histone-serine phosphorylation (GO:0035404)2.54637221
123regulation of ARF protein signal transduction (GO:0032012)2.54172880
124ganglion development (GO:0061548)2.54109262
125membrane repolarization (GO:0086009)2.53905194
126membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.53852385
127neuron recognition (GO:0008038)2.53463243
128meiotic chromosome segregation (GO:0045132)2.53316948
129establishment of integrated proviral latency (GO:0075713)2.52770102
130potassium ion homeostasis (GO:0055075)2.51826329
131regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.51715405
132cell migration in hindbrain (GO:0021535)2.51639215
133regulation of centrosome duplication (GO:0010824)2.50874602
134sister chromatid cohesion (GO:0007062)2.50814770
135negative regulation of synaptic transmission, GABAergic (GO:0032229)2.50532003
136gamma-aminobutyric acid signaling pathway (GO:0007214)2.50473817
137DNA replication-dependent nucleosome organization (GO:0034723)2.50105851
138DNA replication-dependent nucleosome assembly (GO:0006335)2.50105851
139G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49877166
140positive regulation of mitotic sister chromatid separation (GO:1901970)2.49167091
141positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.49167091
142positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.49167091
143cellular sodium ion homeostasis (GO:0006883)2.48900928
144ncRNA catabolic process (GO:0034661)2.48271088
145regulation of centrosome cycle (GO:0046605)2.47647984
146neuromuscular process (GO:0050905)2.47418721
147lateral sprouting from an epithelium (GO:0060601)2.47158508
148long term synaptic depression (GO:0060292)2.46438174
149behavioral response to cocaine (GO:0048148)2.45697632
150reciprocal meiotic recombination (GO:0007131)2.44279402
151reciprocal DNA recombination (GO:0035825)2.44279402
152acrosome assembly (GO:0001675)2.44067372
153spindle checkpoint (GO:0031577)2.43879415
154positive regulation of potassium ion transport (GO:0043268)2.43398994
155kinetochore organization (GO:0051383)2.42850485
156somatic diversification of immune receptors via somatic mutation (GO:0002566)2.42073864
157somatic hypermutation of immunoglobulin genes (GO:0016446)2.42073864
158positive regulation of neurotransmitter transport (GO:0051590)2.41709523
159positive regulation of cardiac muscle hypertrophy (GO:0010613)2.41098683
160positive regulation of muscle hypertrophy (GO:0014742)2.41098683
161somatic recombination of immunoglobulin gene segments (GO:0016447)2.39134981
162regulation of helicase activity (GO:0051095)2.38446071
163regulation of sister chromatid segregation (GO:0033045)2.37600944
164regulation of mitotic sister chromatid separation (GO:0010965)2.37600944
165regulation of mitotic sister chromatid segregation (GO:0033047)2.37600944
166regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.37193612
167mitotic metaphase plate congression (GO:0007080)2.36929101
168regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.36410096
169regulation of mitotic metaphase/anaphase transition (GO:0030071)2.36410096
170protein localization to chromosome, centromeric region (GO:0071459)2.35045607
171heterochromatin organization (GO:0070828)2.33120312
172limb bud formation (GO:0060174)2.32578385
173DNA replication-independent nucleosome organization (GO:0034724)2.31703878
174DNA replication-independent nucleosome assembly (GO:0006336)2.31703878
175olfactory bulb development (GO:0021772)2.31269618
176spermatid nucleus differentiation (GO:0007289)2.30403796
177negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.29816358
178negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.29816358
179negative regulation of mitotic sister chromatid segregation (GO:0033048)2.29816358
180negative regulation of mitotic sister chromatid separation (GO:2000816)2.29816358
181negative regulation of sister chromatid segregation (GO:0033046)2.29816358
182resolution of meiotic recombination intermediates (GO:0000712)2.29468357
183regulation of Rac protein signal transduction (GO:0035020)2.29347005
184negative regulation of chromosome segregation (GO:0051985)2.29128141
185microtubule anchoring (GO:0034453)2.28112552
186mitotic spindle checkpoint (GO:0071174)2.27868367
187synapsis (GO:0007129)2.27202950
188somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.26492948
189isotype switching (GO:0045190)2.26492948
190somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.26492948
191regulation of nuclear cell cycle DNA replication (GO:0033262)2.26263835
192protein localization to chromosome (GO:0034502)2.26168655
193regulation of sister chromatid cohesion (GO:0007063)2.25986213
194neuron projection extension involved in neuron projection guidance (GO:1902284)2.25211555
195axon extension involved in axon guidance (GO:0048846)2.25211555
196regulation of histone H3-K9 methylation (GO:0051570)2.25112449
197atrial cardiac muscle cell action potential (GO:0086014)2.25074433
198regulation of chromosome segregation (GO:0051983)2.23923798
199histone H3-K9 methylation (GO:0051567)2.23563544
200presynaptic membrane assembly (GO:0097105)2.23275636

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.25684432
2E2F7_22180533_ChIP-Seq_HELA_Human3.68013573
3GBX2_23144817_ChIP-Seq_PC3_Human3.40464512
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.85231667
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.63002334
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.54695607
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54419105
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.51973944
9IGF1R_20145208_ChIP-Seq_DFB_Human2.44176603
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.41930268
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.40714872
12DROSHA_22980978_ChIP-Seq_HELA_Human2.37237097
13EWS_26573619_Chip-Seq_HEK293_Human2.27914707
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27232085
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20039080
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20039080
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.16936892
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.12028088
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05772209
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05490050
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03026386
22REST_21632747_ChIP-Seq_MESCs_Mouse2.02694737
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02347245
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99746520
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99113583
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96521121
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.94972323
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89453706
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.86610878
30VDR_22108803_ChIP-Seq_LS180_Human1.84315171
31ELK1_19687146_ChIP-ChIP_HELA_Human1.79874141
32AR_21572438_ChIP-Seq_LNCaP_Human1.78392146
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.75203632
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.73896572
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.71650008
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.71519837
37AR_21909140_ChIP-Seq_LNCAP_Human1.68345922
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67448863
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63451318
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.60872193
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60326923
42TAF15_26573619_Chip-Seq_HEK293_Human1.58389065
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56863844
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53571636
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.51889024
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.49093248
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47993240
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47051216
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47047414
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46826157
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.46717048
52KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46651195
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46340741
54STAT3_23295773_ChIP-Seq_U87_Human1.46226424
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45846921
56TP53_16413492_ChIP-PET_HCT116_Human1.45443543
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.44759247
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43242509
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41817285
60P300_19829295_ChIP-Seq_ESCs_Human1.39271348
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38923324
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38851234
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.38753015
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.37548471
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35928064
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35825711
67* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35360964
68AR_19668381_ChIP-Seq_PC3_Human1.34979229
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34904142
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34701834
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33784904
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33070959
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33015866
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.32756800
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31485859
76AR_25329375_ChIP-Seq_VCAP_Human1.31123720
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30897767
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.29258742
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27877140
80* MYC_18940864_ChIP-ChIP_HL60_Human1.24825005
81TCF4_23295773_ChIP-Seq_U87_Human1.23463067
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.23355101
83* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23228776
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21971715
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21836191
86SOX9_26525672_Chip-Seq_HEART_Mouse1.21830654
87ZNF274_21170338_ChIP-Seq_K562_Hela1.20703991
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20348111
89ER_23166858_ChIP-Seq_MCF-7_Human1.19732698
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19716245
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.18792643
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18662711
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18586026
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18387455
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.18228361
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18002497
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16651305
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16099958
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15759612
100CBP_20019798_ChIP-Seq_JUKART_Human1.15759612
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15270172
102RXR_22108803_ChIP-Seq_LS180_Human1.15200468
103SOX2_16153702_ChIP-ChIP_HESCs_Human1.15199334
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14104723
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.13590962
106SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13521052
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13251316
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12522920
109EST1_17652178_ChIP-ChIP_JURKAT_Human1.12357970
110* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12122101
111AHR_22903824_ChIP-Seq_MCF-7_Human1.11416652
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11413106
113NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11313307
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11275141
115FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10644503
116SMAD4_21741376_ChIP-Seq_HESCs_Human1.09533760
117TCF4_22108803_ChIP-Seq_LS180_Human1.09159139
118IRF1_19129219_ChIP-ChIP_H3396_Human1.08793220
119TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08351504
120RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08305771
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08094157
122TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08059293
123ESR1_20079471_ChIP-ChIP_T-47D_Human1.07831923
124STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07769851
125DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07133323
126* RUNX2_22187159_ChIP-Seq_PCA_Human1.04224671
127NANOG_16153702_ChIP-ChIP_HESCs_Human1.03762752
128P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03653900
129KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03413433
130P53_22387025_ChIP-Seq_ESCs_Mouse1.03172288
131FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03063421
132SALL1_21062744_ChIP-ChIP_HESCs_Human1.02996572
133RING1B_27294783_Chip-Seq_ESCs_Mouse1.02673856
134BCAT_22108803_ChIP-Seq_LS180_Human1.02202498
135BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02165879
136FOXA2_19822575_ChIP-Seq_HepG2_Human1.02073642
137NFE2_27457419_Chip-Seq_LIVER_Mouse1.01592080
138CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00940655
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00659394
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00145504
141POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00145504
142POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99116740
143CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99077238
144EP300_21415370_ChIP-Seq_HL-1_Mouse0.98224581
145FUS_26573619_Chip-Seq_HEK293_Human0.98132743
146TCF4_18268006_ChIP-ChIP_LS174T_Human0.97627049
147CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97438686
148RNF2_27304074_Chip-Seq_NSC_Mouse0.97240411
149SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96808035
150SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96695347
151BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96350752
152KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96329622
153E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96103215
154NOTCH1_21737748_ChIP-Seq_TLL_Human0.95900612
155* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95450485
156PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94906095
157NANOG_18555785_Chip-Seq_ESCs_Mouse0.93506928
158TP53_18474530_ChIP-ChIP_U2OS_Human0.93423944
159RING1B_27294783_Chip-Seq_NPCs_Mouse0.92881048
160VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92490706
161UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92349222
162KDM2B_26808549_Chip-Seq_K562_Human0.91637271
163E2F1_18555785_Chip-Seq_ESCs_Mouse0.90485162
164MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90416840

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.02014239
2MP0003635_abnormal_synaptic_transmissio3.69051655
3MP0008057_abnormal_DNA_replication3.48908778
4MP0006292_abnormal_olfactory_placode3.43704509
5MP0004270_analgesia3.16338807
6MP0009046_muscle_twitch3.14317029
7MP0000569_abnormal_digit_pigmentation3.09790006
8MP0009745_abnormal_behavioral_response3.06391173
9MP0002063_abnormal_learning/memory/cond2.95882464
10MP0003880_abnormal_central_pattern2.87060527
11MP0003890_abnormal_embryonic-extraembry2.86261766
12MP0002064_seizures2.74591840
13MP0001486_abnormal_startle_reflex2.71079236
14MP0002572_abnormal_emotion/affect_behav2.47956418
15MP0002822_catalepsy2.44850187
16MP0001293_anophthalmia2.35508508
17MP0001968_abnormal_touch/_nociception2.26978948
18MP0009780_abnormal_chondrocyte_physiolo2.26944588
19MP0010094_abnormal_chromosome_stability2.22847699
20MP0002272_abnormal_nervous_system2.18493165
21MP0008058_abnormal_DNA_repair2.13045865
22MP0008877_abnormal_DNA_methylation2.12238628
23MP0001501_abnormal_sleep_pattern2.06750968
24MP0002734_abnormal_mechanical_nocicepti1.99190226
25MP0005423_abnormal_somatic_nervous1.98644515
26MP0002938_white_spotting1.97257945
27MP0005646_abnormal_pituitary_gland1.96803254
28MP0000566_synostosis1.95952233
29MP0003937_abnormal_limbs/digits/tail_de1.95687027
30MP0002067_abnormal_sensory_capabilities1.86693953
31MP0003787_abnormal_imprinting1.81055630
32MP0001440_abnormal_grooming_behavior1.80175858
33MP0004957_abnormal_blastocyst_morpholog1.75656312
34MP0005085_abnormal_gallbladder_physiolo1.74287079
35MP0003077_abnormal_cell_cycle1.73328851
36MP0002139_abnormal_hepatobiliary_system1.72887179
37MP0003693_abnormal_embryo_hatching1.71796280
38MP0004885_abnormal_endolymph1.71371672
39MP0005386_behavior/neurological_phenoty1.70650834
40MP0004924_abnormal_behavior1.70650834
41MP0002009_preneoplasia1.69252795
42MP0002233_abnormal_nose_morphology1.69128503
43MP0003122_maternal_imprinting1.68967605
44MP0002909_abnormal_adrenal_gland1.67760149
45MP0003941_abnormal_skin_development1.65651349
46MP0008569_lethality_at_weaning1.64702546
47MP0002557_abnormal_social/conspecific_i1.64414972
48MP0002735_abnormal_chemical_nociception1.59220383
49MP0003252_abnormal_bile_duct1.58328568
50MP0003111_abnormal_nucleus_morphology1.57905856
51MP0001188_hyperpigmentation1.55884811
52MP0004811_abnormal_neuron_physiology1.54366982
53MP0005365_abnormal_bile_salt1.54153184
54MP0001286_abnormal_eye_development1.54148213
55MP0003567_abnormal_fetal_cardiomyocyte1.53615287
56MP0003136_yellow_coat_color1.51347425
57MP0002697_abnormal_eye_size1.50135746
58MP0002733_abnormal_thermal_nociception1.49968786
59MP0000778_abnormal_nervous_system1.49625249
60MP0002184_abnormal_innervation1.48390810
61MP0002736_abnormal_nociception_after1.47663709
62MP0005360_urolithiasis1.46397263
63MP0003633_abnormal_nervous_system1.45949445
64MP0000631_abnormal_neuroendocrine_gland1.45606401
65MP0005645_abnormal_hypothalamus_physiol1.45047901
66MP0010030_abnormal_orbit_morphology1.44480427
67MP0003690_abnormal_glial_cell1.42328246
68MP0002751_abnormal_autonomic_nervous1.41795190
69MP0008932_abnormal_embryonic_tissue1.41785022
70MP0001984_abnormal_olfaction1.41533008
71MP0006276_abnormal_autonomic_nervous1.41510525
72MP0002102_abnormal_ear_morphology1.39164242
73MP0001970_abnormal_pain_threshold1.35350048
74MP0006072_abnormal_retinal_apoptosis1.33732628
75MP0004858_abnormal_nervous_system1.32750056
76MP0000955_abnormal_spinal_cord1.32724001
77MP0003119_abnormal_digestive_system1.29808858
78MP0001299_abnormal_eye_distance/1.26454586
79MP0003755_abnormal_palate_morphology1.26446770
80MP0004197_abnormal_fetal_growth/weight/1.25787020
81MP0002084_abnormal_developmental_patter1.25495796
82MP0000579_abnormal_nail_morphology1.24195870
83MP0003879_abnormal_hair_cell1.23507132
84MP0002066_abnormal_motor_capabilities/c1.23002674
85MP0000428_abnormal_craniofacial_morphol1.21982313
86MP0003861_abnormal_nervous_system1.19768209
87MP0003718_maternal_effect1.19219313
88MP0002234_abnormal_pharynx_morphology1.18468524
89MP0008789_abnormal_olfactory_epithelium1.18012762
90MP0002882_abnormal_neuron_morphology1.16649096
91MP0001177_atelectasis1.16401197
92MP0003868_abnormal_feces_composition1.16401021
93MP0009672_abnormal_birth_weight1.16337644
94MP0000427_abnormal_hair_cycle1.16132801
95MP0000751_myopathy1.14602734
96MP0003631_nervous_system_phenotype1.13870202
97MP0009703_decreased_birth_body1.13813119
98MP0004130_abnormal_muscle_cell1.12785926
99MP0008875_abnormal_xenobiotic_pharmacok1.12394569
100MP0005391_vision/eye_phenotype1.12103882
101MP0009697_abnormal_copulation1.11265265
102MP0002092_abnormal_eye_morphology1.10092212
103MP0001502_abnormal_circadian_rhythm1.09883579
104MP0008874_decreased_physiological_sensi1.08459691
105MP0005253_abnormal_eye_physiology1.07755606
106MP0000537_abnormal_urethra_morphology1.06486654
107MP0004142_abnormal_muscle_tone1.06118272
108MP0002085_abnormal_embryonic_tissue1.06116470
109MP0003329_amyloid_beta_deposits1.06011131
110MP0004085_abnormal_heartbeat1.05062223
111MP0010329_abnormal_lipoprotein_level1.04039754
112MP0009053_abnormal_anal_canal1.03712142
113MP0002160_abnormal_reproductive_system1.01735525
114MP0004133_heterotaxia1.01717300
115MP0001672_abnormal_embryogenesis/_devel1.01559762
116MP0005380_embryogenesis_phenotype1.01559762
117MP0008007_abnormal_cellular_replicative0.99007088
118MP0003935_abnormal_craniofacial_develop0.97281518
119MP0002152_abnormal_brain_morphology0.96702938
120MP0005551_abnormal_eye_electrophysiolog0.96342717
121MP0005535_abnormal_body_temperature0.95306906
122MP0002111_abnormal_tail_morphology0.94754799
123MP0000049_abnormal_middle_ear0.94708044
124MP0004215_abnormal_myocardial_fiber0.94655825
125MP0001697_abnormal_embryo_size0.94099621
126MP0000432_abnormal_head_morphology0.93692920
127MP0002069_abnormal_eating/drinking_beha0.92994272
128MP0005187_abnormal_penis_morphology0.90477042
129MP0004145_abnormal_muscle_electrophysio0.90144055
130MP0008872_abnormal_physiological_respon0.89028252
131MP0003984_embryonic_growth_retardation0.88224230
132MP0002088_abnormal_embryonic_growth/wei0.87607572
133MP0002090_abnormal_vision0.87375065
134MP0002638_abnormal_pupillary_reflex0.87130130
135MP0003385_abnormal_body_wall0.86220197
136MP0008961_abnormal_basal_metabolism0.85806791
137MP0001730_embryonic_growth_arrest0.85629729
138MP0001529_abnormal_vocalization0.85393267
139MP0002229_neurodegeneration0.84393199
140MP0003315_abnormal_perineum_morphology0.84159092
141MP0001346_abnormal_lacrimal_gland0.82242107
142MP0001929_abnormal_gametogenesis0.82173232
143MP0009250_abnormal_appendicular_skeleto0.82148031
144MP0003123_paternal_imprinting0.81747041
145MP0000647_abnormal_sebaceous_gland0.81721425
146MP0003942_abnormal_urinary_system0.81462095
147MP0002210_abnormal_sex_determination0.80846571
148MP0003045_fibrosis0.80708517
149MP0002752_abnormal_somatic_nervous0.80702426
150MP0000013_abnormal_adipose_tissue0.80023518
151MP0010352_gastrointestinal_tract_polyps0.79945313
152MP0003632_abnormal_nervous_system0.77551931
153MP0002081_perinatal_lethality0.77350149
154MP0000350_abnormal_cell_proliferation0.77112629
155MP0003172_abnormal_lysosome_physiology0.76629557
156MP0003137_abnormal_impulse_conducting0.75974041
157MP0000920_abnormal_myelination0.73462615
158MP0003634_abnormal_glial_cell0.71293474
159MP0003121_genomic_imprinting0.71032858
160MP0000639_abnormal_adrenal_gland0.66831434
161MP0004742_abnormal_vestibular_system0.65100208
162MP0005167_abnormal_blood-brain_barrier0.65049239
163MP0004233_abnormal_muscle_weight0.64775389
164MP0005248_abnormal_Harderian_gland0.63916939
165MP0001485_abnormal_pinna_reflex0.62867030
166MP0003075_altered_response_to0.62789306
167MP0002118_abnormal_lipid_homeostasis0.62755050
168MP0000003_abnormal_adipose_tissue0.62137163
169MP0001963_abnormal_hearing_physiology0.60330322
170MP0000747_muscle_weakness0.59645567
171MP0004484_altered_response_of0.59500215
172MP0003283_abnormal_digestive_organ0.59353293
173MP0002078_abnormal_glucose_homeostasis0.58919835
174MP0005394_taste/olfaction_phenotype0.58854485
175MP0005499_abnormal_olfactory_system0.58854485
176MP0010770_preweaning_lethality0.58802812

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.58519064
2Myokymia (HP:0002411)4.91681609
3Focal seizures (HP:0007359)4.48755316
4Action tremor (HP:0002345)4.43561353
5Febrile seizures (HP:0002373)3.92416247
6Progressive cerebellar ataxia (HP:0002073)3.63580885
7Epileptic encephalopathy (HP:0200134)3.58467605
8Volvulus (HP:0002580)3.57920617
9Hyperventilation (HP:0002883)3.41558136
10Visual hallucinations (HP:0002367)3.36889576
11Generalized tonic-clonic seizures (HP:0002069)3.27322186
12Atonic seizures (HP:0010819)3.25669037
13Colon cancer (HP:0003003)3.25632087
14Impaired vibration sensation in the lower limbs (HP:0002166)3.22225831
15Absence seizures (HP:0002121)3.22147585
16Abnormal social behavior (HP:0012433)3.21965322
17Impaired social interactions (HP:0000735)3.21965322
18Poor eye contact (HP:0000817)3.11139586
19Gaze-evoked nystagmus (HP:0000640)2.96589843
20Macroorchidism (HP:0000053)2.91035172
21Dysdiadochokinesis (HP:0002075)2.86298086
22Genetic anticipation (HP:0003743)2.80911724
23Postural instability (HP:0002172)2.79127971
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.78865708
25Dysmetric saccades (HP:0000641)2.76774183
26Dialeptic seizures (HP:0011146)2.76516170
27Urinary bladder sphincter dysfunction (HP:0002839)2.75637987
28Status epilepticus (HP:0002133)2.74615507
29Scanning speech (HP:0002168)2.74298509
30Chromsome breakage (HP:0040012)2.72673449
31Broad-based gait (HP:0002136)2.71818256
32Drooling (HP:0002307)2.70177381
33Excessive salivation (HP:0003781)2.70177381
34Abnormality of the labia minora (HP:0012880)2.70032633
35Abnormality of chromosome stability (HP:0003220)2.63981964
36Depression (HP:0000716)2.56955787
37Hemiplegia (HP:0002301)2.51131218
38Truncal ataxia (HP:0002078)2.49176689
39Urinary urgency (HP:0000012)2.45921294
40Termporal pattern (HP:0011008)2.44556295
41Insidious onset (HP:0003587)2.44556295
42Intention tremor (HP:0002080)2.43085499
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.42743853
44Glioma (HP:0009733)2.42615300
45Dysmetria (HP:0001310)2.42559489
46Meckel diverticulum (HP:0002245)2.42496610
47Astrocytoma (HP:0009592)2.37898316
48Abnormality of the astrocytes (HP:0100707)2.37898316
49Oligodactyly (hands) (HP:0001180)2.37329172
50Abnormality of the ileum (HP:0001549)2.33457882
51Impaired smooth pursuit (HP:0007772)2.31590585
52Nephronophthisis (HP:0000090)2.29655949
53Intestinal atresia (HP:0011100)2.29630669
54Septo-optic dysplasia (HP:0100842)2.28964570
55Abnormality of the lower motor neuron (HP:0002366)2.27621215
56Anxiety (HP:0000739)2.27408551
57Pancreatic cysts (HP:0001737)2.27340429
58Elfin facies (HP:0004428)2.24217381
59Impaired vibratory sensation (HP:0002495)2.21767539
60Genital tract atresia (HP:0001827)2.19107606
61Supernumerary spleens (HP:0009799)2.18620630
62Ectopic kidney (HP:0000086)2.17642604
63Blue irides (HP:0000635)2.17066968
64Vaginal atresia (HP:0000148)2.15321810
65Abnormality of ocular smooth pursuit (HP:0000617)2.15308561
66Ankle clonus (HP:0011448)2.13702210
67Papilledema (HP:0001085)2.13550916
68Abnormal lung lobation (HP:0002101)2.12620319
69Pancreatic fibrosis (HP:0100732)2.11915859
70Abnormality of the renal medulla (HP:0100957)2.11852173
71Oligodactyly (HP:0012165)2.11841506
72Aqueductal stenosis (HP:0002410)2.11474032
73Aplasia/Hypoplasia of the sternum (HP:0006714)2.10730227
74Pheochromocytoma (HP:0002666)2.10580211
75Supranuclear gaze palsy (HP:0000605)2.10516246
76Rhabdomyosarcoma (HP:0002859)2.09405106
77Megalencephaly (HP:0001355)2.09120813
78Absent speech (HP:0001344)2.09038628
79Torticollis (HP:0000473)2.08687314
80Papillary thyroid carcinoma (HP:0002895)2.06262774
81Renovascular hypertension (HP:0100817)2.06171919
82Esophageal atresia (HP:0002032)2.03291657
83Ependymoma (HP:0002888)2.01774928
84Obsessive-compulsive behavior (HP:0000722)2.01645418
85Postural tremor (HP:0002174)2.01243996
86Insomnia (HP:0100785)2.00238017
87Abnormal eating behavior (HP:0100738)1.99597961
88Congenital primary aphakia (HP:0007707)1.97846542
89High anterior hairline (HP:0009890)1.97844042
90Epileptiform EEG discharges (HP:0011182)1.96969312
91Medial flaring of the eyebrow (HP:0010747)1.96903946
92EEG with generalized epileptiform discharges (HP:0011198)1.95942894
93Neoplasm of the adrenal cortex (HP:0100641)1.95490665
94Fair hair (HP:0002286)1.95250304
95Poor coordination (HP:0002370)1.93900220
96Optic nerve hypoplasia (HP:0000609)1.93672759
97Pointed chin (HP:0000307)1.93389610
98Nephroblastoma (Wilms tumor) (HP:0002667)1.93354897
99Preaxial hand polydactyly (HP:0001177)1.92957886
100Sloping forehead (HP:0000340)1.92881762
101Gait imbalance (HP:0002141)1.91926378
102Hyperacusis (HP:0010780)1.91237612
103Hypsarrhythmia (HP:0002521)1.90160604
104Abnormality of the preputium (HP:0100587)1.89654372
105Resting tremor (HP:0002322)1.88950841
106True hermaphroditism (HP:0010459)1.88444216
107Tubulointerstitial nephritis (HP:0001970)1.88072452
108Bradykinesia (HP:0002067)1.88021614
109Bifid tongue (HP:0010297)1.87410852
110Gastrointestinal atresia (HP:0002589)1.87276326
111Inappropriate behavior (HP:0000719)1.85884382
112Embryonal renal neoplasm (HP:0011794)1.85237620
113Spastic gait (HP:0002064)1.84291220
114Exotropia (HP:0000577)1.83178072
115Absent radius (HP:0003974)1.82298047
116Stereotypic behavior (HP:0000733)1.81894192
117Medulloblastoma (HP:0002885)1.79596114
118Triphalangeal thumb (HP:0001199)1.79306801
119Abnormality of saccadic eye movements (HP:0000570)1.78545784
120Neoplasm of the small intestine (HP:0100833)1.78534660
121Increased nuchal translucency (HP:0010880)1.78511451
122Aplasia/Hypoplasia of the tongue (HP:0010295)1.78369669
123Abnormality of the septum pellucidum (HP:0007375)1.77940930
124Anophthalmia (HP:0000528)1.77706715
125Hepatoblastoma (HP:0002884)1.77618845
126Abnormality of chromosome segregation (HP:0002916)1.77411258
127Nephrogenic diabetes insipidus (HP:0009806)1.76698254
128Postaxial foot polydactyly (HP:0001830)1.76473675
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75984732
130Focal dystonia (HP:0004373)1.75569872
131Arterial tortuosity (HP:0005116)1.74531935
132Absent eyebrow (HP:0002223)1.74303959
133Cutaneous finger syndactyly (HP:0010554)1.74270994
134Hypoplastic pelvis (HP:0008839)1.73816045
135Lower limb muscle weakness (HP:0007340)1.73459084
136Lower limb asymmetry (HP:0100559)1.73373535
137Absent forearm bone (HP:0003953)1.72658594
138Aplasia involving forearm bones (HP:0009822)1.72658594
139Prolonged QT interval (HP:0001657)1.71979670
140Mutism (HP:0002300)1.71197540
141Biliary tract neoplasm (HP:0100574)1.71181173
142Turricephaly (HP:0000262)1.70523124
143Impulsivity (HP:0100710)1.70479082
144Renal hypoplasia (HP:0000089)1.70270480
145Postaxial hand polydactyly (HP:0001162)1.69410824
146Hypoplastic labia majora (HP:0000059)1.68466969
147Molar tooth sign on MRI (HP:0002419)1.68318104
148Abnormality of midbrain morphology (HP:0002418)1.68318104
149Abnormality of the nasal septum (HP:0000419)1.68150142
150Mitral stenosis (HP:0001718)1.67461444
151Abnormality of the corticospinal tract (HP:0002492)1.66309131
152Neuronal loss in central nervous system (HP:0002529)1.65987370
153Gait ataxia (HP:0002066)1.65215138
154Neoplasm of striated muscle (HP:0009728)1.65180042
155Ventricular fibrillation (HP:0001663)1.64994655
156Chronic hepatic failure (HP:0100626)1.64685708
157Abnormal EKG (HP:0003115)1.64424121
158Dandy-Walker malformation (HP:0001305)1.64062948
159Preaxial foot polydactyly (HP:0001841)1.63234938
160Absent septum pellucidum (HP:0001331)1.62918173
161Cerebral aneurysm (HP:0004944)1.62494955
162Retinal atrophy (HP:0001105)1.62326216
163Abnormality of the duodenum (HP:0002246)1.62241935
164Micropenis (HP:0000054)1.61763598
165Neoplasm of the colon (HP:0100273)1.61760589
166Striae distensae (HP:0001065)1.61527437
167Deep venous thrombosis (HP:0002625)1.61407221
168Craniofacial dystonia (HP:0012179)1.59395713
169Stenosis of the external auditory canal (HP:0000402)1.58072183
170Agitation (HP:0000713)1.57906303
171Renal duplication (HP:0000075)1.57328167
172Abnormality of salivation (HP:0100755)1.57005651
173Overriding aorta (HP:0002623)1.56959442
174Facial hemangioma (HP:0000329)1.56880860
175Cystic hygroma (HP:0000476)1.56746004
176Hyperglycinemia (HP:0002154)1.56304865
177Abnormality of the renal cortex (HP:0011035)1.55912717
178Hypoplastic female external genitalia (HP:0012815)1.55629349
179Diplopia (HP:0000651)1.55615229
180Abnormality of binocular vision (HP:0011514)1.55615229
181Thyroid carcinoma (HP:0002890)1.55592997
182Abnormality of abdominal situs (HP:0011620)1.55369821
183Abdominal situs inversus (HP:0003363)1.55369821
184Tetraplegia (HP:0002445)1.54388565
185Small intestinal stenosis (HP:0012848)1.54248617
186Neuroendocrine neoplasm (HP:0100634)1.53820274
187Protruding tongue (HP:0010808)1.53637388
188Clonus (HP:0002169)1.53429303
189Bundle branch block (HP:0011710)1.53111364
190Generalized hypopigmentation of hair (HP:0011358)1.52504788

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.01457230
2EPHA43.30303460
3MKNK23.24847480
4MAP3K92.92036769
5MAP3K42.86032489
6MKNK12.78437200
7BRSK22.69810674
8BCR2.36634864
9MINK12.35193332
10SIK22.32242584
11MARK12.26580205
12CAMK1G2.22930815
13MAP2K72.13062006
14MAP2K42.11965662
15ZAK2.09996676
16BRD42.07770025
17TSSK62.07042125
18DAPK22.04897119
19CAMKK12.04665544
20CDC72.04435715
21TRIM282.04315697
22STK38L1.94541322
23SRPK11.92228609
24SIK11.87853743
25TTK1.87707874
26PLK31.83025637
27NTRK21.79843329
28CAMK1D1.79036836
29SGK21.76861768
30SGK31.76022494
31WNK31.74510769
32NUAK11.73369094
33PRKD31.67181693
34BMPR1B1.66269074
35EIF2AK31.65571146
36MAP3K131.63690523
37SIK31.63544070
38TAF11.58326536
39PAK61.55875505
40STK381.50516340
41KSR21.48222618
42MAP3K101.45607442
43WNK11.44571227
44CAMKK21.43094324
45WEE11.42030892
46SGK4941.39147135
47SGK2231.39147135
48PLK41.36746899
49TRPM71.35455065
50STK31.34561454
51KSR11.33822323
52NTRK11.23397058
53PLK21.18994547
54CDK51.18354303
55STK241.17888458
56PRKCH1.15735074
57MAPK131.14897886
58BUB11.12724881
59RIPK11.11947457
60AKT31.11520827
61PBK1.11501652
62FGFR21.10977240
63STK391.10165121
64CASK1.09813801
65BRSK11.09284440
66TNIK1.06386378
67PHKG21.05003900
68PHKG11.05003900
69PLK11.04893913
70MST41.04044327
71MAP3K21.03075817
72RET1.02281213
73CDK191.01015048
74INSRR0.99722530
75CAMK10.99252995
76ALK0.99003308
77LMTK20.98980521
78MAP3K70.98274121
79RIPK40.97327884
80TYRO30.95673655
81PASK0.94827371
82PRKCG0.92122434
83CSNK1G10.91233167
84PNCK0.90269705
85SGK10.88942952
86TGFBR10.88020377
87ERBB30.87139255
88CAMK40.85962483
89NLK0.84426233
90PDGFRA0.84349811
91MAP3K120.84141356
92TAOK10.83379977
93ATM0.82684266
94PRPF4B0.82140899
95STK110.81604572
96ACVR1B0.81239562
97DAPK10.81143093
98NEK90.80843528
99TNK20.80414212
100OXSR10.79394889
101ATR0.79278615
102LATS20.78760589
103CDC42BPA0.78191393
104DYRK30.76125468
105CHEK20.72378220
106ERBB40.69637203
107PAK30.69632582
108GRK70.67773271
109RPS6KA30.67760650
110CHEK10.67679099
111CSNK1A1L0.66076359
112PDK10.65853991
113LATS10.64507346
114CAMK2A0.64195783
115EIF2AK10.63785539
116AURKB0.63208184
117EIF2AK20.62948916
118CDK60.62307429
119TRIB30.62132283
120FES0.62054275
121UHMK10.60871918
122NEK20.60560711
123MAPK100.59395208
124MARK20.58934122
125PDGFRB0.57739061
126WNK40.57710310
127TGFBR20.57288873
128CSNK1E0.56979153
129CSNK1G20.54953524
130YES10.54602839
131PRKCZ0.54528028
132DDR20.54398903
133RPS6KA40.52906503
134CDK30.52361842
135FRK0.52355451
136FLT30.52290801
137GRK50.52142327
138ERBB20.51988810
139PDPK10.51970899
140CSNK1D0.51496499
141VRK10.50876629
142OBSCN0.50389287
143MAP4K20.50356748
144MELK0.48808235
145PINK10.48656665
146PRKAA10.47903947
147PRKCE0.47784940
148CDK10.46957196
149FGFR10.46734951
150NEK60.46003812
151PKN20.45874366
152DYRK1A0.45488761
153CSNK1G30.44775440
154RPS6KB20.44178978
155BMX0.43757028
156PRKDC0.42869484
157RPS6KB10.42149014
158PRKCB0.41876385
159MAPK80.40983793
160MAPK120.40976217
161PTK2B0.40489234
162PRKAA20.39422260
163MAP3K10.38857676
164DMPK0.38849146
165FYN0.38775124
166CDK180.37814780
167NEK10.37588920
168PRKG10.37220798
169RPS6KA20.37171188

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.75906433
2Nitrogen metabolism_Homo sapiens_hsa009103.34359870
3Nicotine addiction_Homo sapiens_hsa050332.74913669
4Fanconi anemia pathway_Homo sapiens_hsa034602.45076899
5Mismatch repair_Homo sapiens_hsa034302.34421305
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32670922
7Cell cycle_Homo sapiens_hsa041102.24485619
8RNA transport_Homo sapiens_hsa030132.22327586
9GABAergic synapse_Homo sapiens_hsa047272.21714867
10Basal transcription factors_Homo sapiens_hsa030222.20909936
11Protein export_Homo sapiens_hsa030602.17428306
12Circadian entrainment_Homo sapiens_hsa047132.15423459
13Olfactory transduction_Homo sapiens_hsa047402.14133649
14RNA degradation_Homo sapiens_hsa030182.10710306
15Hedgehog signaling pathway_Homo sapiens_hsa043402.07638278
16Long-term potentiation_Homo sapiens_hsa047202.06808411
17Synaptic vesicle cycle_Homo sapiens_hsa047212.05648295
18Glutamatergic synapse_Homo sapiens_hsa047242.03443754
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.01381195
20Morphine addiction_Homo sapiens_hsa050321.97839934
21Basal cell carcinoma_Homo sapiens_hsa052171.97251318
22Homologous recombination_Homo sapiens_hsa034401.95922204
23Spliceosome_Homo sapiens_hsa030401.93913510
24mRNA surveillance pathway_Homo sapiens_hsa030151.90056751
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89627219
26Amphetamine addiction_Homo sapiens_hsa050311.87767040
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87190873
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.79937337
29Hippo signaling pathway_Homo sapiens_hsa043901.78634278
30DNA replication_Homo sapiens_hsa030301.71269433
31RNA polymerase_Homo sapiens_hsa030201.67460389
32Insulin secretion_Homo sapiens_hsa049111.67453060
33Dopaminergic synapse_Homo sapiens_hsa047281.67225844
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66026340
35Salivary secretion_Homo sapiens_hsa049701.65606927
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63218576
37Nucleotide excision repair_Homo sapiens_hsa034201.58104678
38Selenocompound metabolism_Homo sapiens_hsa004501.57954068
39Renin secretion_Homo sapiens_hsa049241.53337094
40Steroid biosynthesis_Homo sapiens_hsa001001.53325575
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52972073
42Cholinergic synapse_Homo sapiens_hsa047251.52515305
43Gastric acid secretion_Homo sapiens_hsa049711.49750227
44Cocaine addiction_Homo sapiens_hsa050301.47524786
45Type II diabetes mellitus_Homo sapiens_hsa049301.46881689
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46858059
47Arginine biosynthesis_Homo sapiens_hsa002201.45835971
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40724209
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.40606096
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.40180658
51Wnt signaling pathway_Homo sapiens_hsa043101.39417527
52One carbon pool by folate_Homo sapiens_hsa006701.38606792
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.37697984
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30828241
55Long-term depression_Homo sapiens_hsa047301.28269312
56TGF-beta signaling pathway_Homo sapiens_hsa043501.28192482
57Oxytocin signaling pathway_Homo sapiens_hsa049211.27701878
58Butanoate metabolism_Homo sapiens_hsa006501.26888127
59p53 signaling pathway_Homo sapiens_hsa041151.25328239
60Bile secretion_Homo sapiens_hsa049761.23035343
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20753136
62Taste transduction_Homo sapiens_hsa047421.19963765
63Calcium signaling pathway_Homo sapiens_hsa040201.19761629
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17557247
65cAMP signaling pathway_Homo sapiens_hsa040241.13249278
66Base excision repair_Homo sapiens_hsa034101.12809354
67Primary bile acid biosynthesis_Homo sapiens_hsa001201.10608501
68GnRH signaling pathway_Homo sapiens_hsa049121.10412196
69Adherens junction_Homo sapiens_hsa045201.10092949
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09891245
71Serotonergic synapse_Homo sapiens_hsa047261.08515869
72Glioma_Homo sapiens_hsa052141.06144941
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06046090
74Vitamin B6 metabolism_Homo sapiens_hsa007501.05604248
75Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04826357
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98746993
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98286613
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97762216
79Gap junction_Homo sapiens_hsa045400.97246917
80Dorso-ventral axis formation_Homo sapiens_hsa043200.95857861
81Estrogen signaling pathway_Homo sapiens_hsa049150.95518296
82ErbB signaling pathway_Homo sapiens_hsa040120.94748197
83Colorectal cancer_Homo sapiens_hsa052100.94518645
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94488001
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91581239
86Glucagon signaling pathway_Homo sapiens_hsa049220.91181281
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90615733
88MicroRNAs in cancer_Homo sapiens_hsa052060.88169115
89Axon guidance_Homo sapiens_hsa043600.85264241
90Tight junction_Homo sapiens_hsa045300.85115869
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83950061
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83553143
93Fatty acid biosynthesis_Homo sapiens_hsa000610.82094258
94Purine metabolism_Homo sapiens_hsa002300.80440613
95Thyroid hormone synthesis_Homo sapiens_hsa049180.77472619
96Lysine degradation_Homo sapiens_hsa003100.77024143
97Melanogenesis_Homo sapiens_hsa049160.76268527
98Thyroid cancer_Homo sapiens_hsa052160.70217787
99Fatty acid metabolism_Homo sapiens_hsa012120.69802023
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69325174
101Dilated cardiomyopathy_Homo sapiens_hsa054140.68145970
102mTOR signaling pathway_Homo sapiens_hsa041500.67500861
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66419951
104Insulin signaling pathway_Homo sapiens_hsa049100.66364496
105Pyrimidine metabolism_Homo sapiens_hsa002400.64134282
106Propanoate metabolism_Homo sapiens_hsa006400.61591403
107Endometrial cancer_Homo sapiens_hsa052130.60983301
108Pancreatic secretion_Homo sapiens_hsa049720.60817843
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.60805489
110Prostate cancer_Homo sapiens_hsa052150.59584624
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.59468037
112Fatty acid degradation_Homo sapiens_hsa000710.59411280
113Insulin resistance_Homo sapiens_hsa049310.58585530
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.58248578
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57836033
116Biosynthesis of amino acids_Homo sapiens_hsa012300.57605576
117Pyruvate metabolism_Homo sapiens_hsa006200.57504700
118Non-small cell lung cancer_Homo sapiens_hsa052230.56877854
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56752076
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56669589
121PPAR signaling pathway_Homo sapiens_hsa033200.56659331
122Choline metabolism in cancer_Homo sapiens_hsa052310.56131750
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56082096
1242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55771774
125Tryptophan metabolism_Homo sapiens_hsa003800.55647659
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55619736
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54076597
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53754974
129MAPK signaling pathway_Homo sapiens_hsa040100.53212992
130Circadian rhythm_Homo sapiens_hsa047100.52574274
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49465036
132FoxO signaling pathway_Homo sapiens_hsa040680.49285820
133ABC transporters_Homo sapiens_hsa020100.48138922
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48062085
135Melanoma_Homo sapiens_hsa052180.47368038
136Rap1 signaling pathway_Homo sapiens_hsa040150.46289584
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46134562
138Regulation of autophagy_Homo sapiens_hsa041400.45275315
139Starch and sucrose metabolism_Homo sapiens_hsa005000.44852267
140AMPK signaling pathway_Homo sapiens_hsa041520.43615948
141Ovarian steroidogenesis_Homo sapiens_hsa049130.43307829
142Complement and coagulation cascades_Homo sapiens_hsa046100.42565113
143Phototransduction_Homo sapiens_hsa047440.42095825
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41301890
145Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40569580
146Ras signaling pathway_Homo sapiens_hsa040140.40518822
147Inositol phosphate metabolism_Homo sapiens_hsa005620.40371319
148Arginine and proline metabolism_Homo sapiens_hsa003300.39919178
149Pathways in cancer_Homo sapiens_hsa052000.38949343
150Central carbon metabolism in cancer_Homo sapiens_hsa052300.38933882
151Renal cell carcinoma_Homo sapiens_hsa052110.38656022
152Oocyte meiosis_Homo sapiens_hsa041140.37440926
153Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37437475
154Adipocytokine signaling pathway_Homo sapiens_hsa049200.37000192
155Proteoglycans in cancer_Homo sapiens_hsa052050.35060204
156Alcoholism_Homo sapiens_hsa050340.33965741
157Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32729293
158PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30015290

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