MUC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pattern specification involved in kidney development (GO:0061004)6.70872491
2intestinal cholesterol absorption (GO:0030299)5.72123355
3desmosome organization (GO:0002934)5.66644926
4exocrine pancreas development (GO:0031017)5.33448736
5protein retention in ER lumen (GO:0006621)5.16879130
6axonemal dynein complex assembly (GO:0070286)5.09566152
7lung lobe morphogenesis (GO:0060463)5.01071842
8digestion (GO:0007586)4.96103610
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.91614902
10primary alcohol catabolic process (GO:0034310)4.66307790
11dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.44408800
12hemidesmosome assembly (GO:0031581)4.39914716
13regulation of water loss via skin (GO:0033561)4.24243010
14diterpenoid biosynthetic process (GO:0016102)4.15107539
15peptide catabolic process (GO:0043171)4.11271546
16ethanol metabolic process (GO:0006067)4.05742767
17motile cilium assembly (GO:0044458)3.97321160
18epithelial cell differentiation involved in prostate gland development (GO:0060742)3.95388545
19water homeostasis (GO:0030104)3.92933414
20transcytosis (GO:0045056)3.81330084
21epithelial cell-cell adhesion (GO:0090136)3.78814678
22cilium or flagellum-dependent cell motility (GO:0001539)3.75832312
23response to xenobiotic stimulus (GO:0009410)3.74520566
24establishment of apical/basal cell polarity (GO:0035089)3.65989099
25endothelial cell chemotaxis (GO:0035767)3.65654976
26establishment of skin barrier (GO:0061436)3.60875931
27oligosaccharide biosynthetic process (GO:0009312)3.60302132
28ear development (GO:0043583)3.59281391
29mammary gland epithelial cell differentiation (GO:0060644)3.57328984
30negative regulation of humoral immune response (GO:0002921)3.56322510
31peptidyl-proline hydroxylation (GO:0019511)3.56133100
32COPI coating of Golgi vesicle (GO:0048205)3.52864308
33Golgi transport vesicle coating (GO:0048200)3.52864308
34intestinal epithelial cell development (GO:0060576)3.51627642
35lung secretory cell differentiation (GO:0061140)3.51170382
36bundle of His cell to Purkinje myocyte communication (GO:0086069)3.44846690
37calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.38702039
38epithelial tube branching involved in lung morphogenesis (GO:0060441)3.38562212
39one-carbon compound transport (GO:0019755)3.37292352
40phosphate ion transmembrane transport (GO:0035435)3.36190963
41cellular response to nitric oxide (GO:0071732)3.35139947
42amyloid precursor protein catabolic process (GO:0042987)3.33444547
43* O-glycan processing (GO:0016266)3.30022475
44glutathione biosynthetic process (GO:0006750)3.29112513
45positive regulation of p38MAPK cascade (GO:1900745)3.26602923
46cilium movement (GO:0003341)3.26010747
47mesodermal cell differentiation (GO:0048333)3.25329730
48maintenance of gastrointestinal epithelium (GO:0030277)3.24262411
49tight junction assembly (GO:0070830)3.23639013
50regulation of interleukin-13 production (GO:0032656)3.23059536
51regulation of cardioblast differentiation (GO:0051890)3.21159095
52regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.21149937
53negative regulation of complement activation (GO:0045916)3.20973386
54branching involved in salivary gland morphogenesis (GO:0060445)3.20199260
55regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.16399150
56semaphorin-plexin signaling pathway (GO:0071526)3.15028619
57negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.13002399
58cell adhesion mediated by integrin (GO:0033627)3.12469571
59regulation of endothelial cell differentiation (GO:0045601)3.11331926
60lung vasculature development (GO:0060426)3.10707535
61interferon-gamma secretion (GO:0072643)3.05952813
62regulation of glomerular filtration (GO:0003093)3.05120063
63cysteine metabolic process (GO:0006534)3.03999576
64segment specification (GO:0007379)3.03766683
65branching involved in mammary gland duct morphogenesis (GO:0060444)3.03578858
66phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.03568956
67phosphate ion homeostasis (GO:0055062)3.02693668
68trivalent inorganic anion homeostasis (GO:0072506)3.02693668
69nonribosomal peptide biosynthetic process (GO:0019184)3.02443758
70establishment of monopolar cell polarity (GO:0061162)3.01729888
71establishment or maintenance of monopolar cell polarity (GO:0061339)3.01729888
72positive regulation of Cdc42 GTPase activity (GO:0043089)3.01313107
73negative regulation of fatty acid transport (GO:2000192)3.00518263
74renal filtration (GO:0097205)3.00056715
75protein localization to endosome (GO:0036010)2.98461503
76regulation of phospholipid biosynthetic process (GO:0071071)2.96995817
77lung epithelium development (GO:0060428)2.95020222
78regulation of vasculogenesis (GO:2001212)2.94855466
79glial cell proliferation (GO:0014009)2.94153833
80embryonic foregut morphogenesis (GO:0048617)2.93513397
81regulation of phospholipase A2 activity (GO:0032429)2.93175273
82regulation of ruffle assembly (GO:1900027)2.93138743
83retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.92956033
84regulation of hippo signaling (GO:0035330)2.91713305
85sodium-independent organic anion transport (GO:0043252)2.91439515
86atrioventricular valve morphogenesis (GO:0003181)2.91187643
87renal absorption (GO:0070293)2.90615896
88cytoskeletal anchoring at plasma membrane (GO:0007016)2.89896498
89polarized epithelial cell differentiation (GO:0030859)2.87172267
90terpenoid biosynthetic process (GO:0016114)2.86700288
91phosphate ion transport (GO:0006817)2.86081938
92amyloid precursor protein metabolic process (GO:0042982)2.84841624
93GDP-mannose metabolic process (GO:0019673)2.84788291
94virion attachment to host cell (GO:0019062)2.84183910
95adhesion of symbiont to host cell (GO:0044650)2.84183910
96iron ion import (GO:0097286)2.82974724
97positive regulation of endothelial cell differentiation (GO:0045603)2.82530974
98regulation of interleukin-5 production (GO:0032674)2.82447671
99regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.82423770
100protein hydroxylation (GO:0018126)2.81791102
101vascular endothelial growth factor signaling pathway (GO:0038084)2.80705423
102lung alveolus development (GO:0048286)2.79865681
103negative regulation of digestive system process (GO:0060457)2.79114892
104growth hormone receptor signaling pathway (GO:0060396)2.78393264
105intestinal absorption (GO:0050892)2.78338864
106negative regulation of protein activation cascade (GO:2000258)2.78191798
107regulation of apoptotic process involved in morphogenesis (GO:1902337)2.77891687
108phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.76434996
109glomerular filtration (GO:0003094)2.74672416
110respiratory gaseous exchange (GO:0007585)2.74472128
111icosanoid transport (GO:0071715)2.73541602
112fatty acid derivative transport (GO:1901571)2.73541602
113long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.73232333
114glutathione derivative biosynthetic process (GO:1901687)2.72932703
115glutathione derivative metabolic process (GO:1901685)2.72932703
116regulation of keratinocyte differentiation (GO:0045616)2.72870117
117negative regulation of response to reactive oxygen species (GO:1901032)2.72864835
118regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.71673014
119regulation of metalloenzyme activity (GO:0048552)2.69393604
120ectoderm development (GO:0007398)2.68992411
121cellular response to reactive nitrogen species (GO:1902170)2.67427424
122complement activation, classical pathway (GO:0006958)2.66591398
123arachidonic acid secretion (GO:0050482)2.66574197
124icosanoid secretion (GO:0032309)2.66574197
125response to nitric oxide (GO:0071731)2.66542868
126endocardial cushion development (GO:0003197)2.66270693
127fatty-acyl-CoA biosynthetic process (GO:0046949)2.65310386
128regulation of endothelial cell chemotaxis (GO:2001026)2.63957901
129branching involved in labyrinthine layer morphogenesis (GO:0060670)2.63389997
130skin morphogenesis (GO:0043589)2.63200921
131morphogenesis of an endothelium (GO:0003159)2.63149297
132endothelial tube morphogenesis (GO:0061154)2.63149297
133planar cell polarity pathway involved in neural tube closure (GO:0090179)2.61530343
134L-ascorbic acid metabolic process (GO:0019852)2.60518165
135regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.59519853
136positive regulation of glycoprotein metabolic process (GO:1903020)2.59459916
137protein autoprocessing (GO:0016540)2.59173677
138cobalamin metabolic process (GO:0009235)2.58721776
139apical protein localization (GO:0045176)2.56812831
140negative regulation of cell fate specification (GO:0009996)2.56631328
141zinc ion transport (GO:0006829)2.56372904
142multicellular organismal water homeostasis (GO:0050891)2.56237569
143renal system process involved in regulation of blood volume (GO:0001977)2.56111817
144adhesion of symbiont to host (GO:0044406)2.55661172
145ethanol oxidation (GO:0006069)2.54940379
146peptidyl-tyrosine autophosphorylation (GO:0038083)2.54423069
147regulation of p38MAPK cascade (GO:1900744)2.53912147
148xenobiotic catabolic process (GO:0042178)2.53897371
149regulation of podosome assembly (GO:0071801)2.53686328
150gas transport (GO:0015669)2.53398004
151negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.53074551
152hepatocyte apoptotic process (GO:0097284)2.53030603
153epithelial structure maintenance (GO:0010669)2.52614105
154pyrimidine-containing compound transmembrane transport (GO:0072531)2.51978989
155cell-cell junction assembly (GO:0007043)2.51477856
156vitamin transmembrane transport (GO:0035461)2.50674033
157diol metabolic process (GO:0034311)2.50549415
158norepinephrine metabolic process (GO:0042415)2.49675532
159digestive system process (GO:0022600)2.48834656
160sodium ion homeostasis (GO:0055078)2.47617520
161primary alcohol metabolic process (GO:0034308)2.47322968
162negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.46704144
163epithelial cilium movement (GO:0003351)2.46476020
164epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.46083596
165face development (GO:0060324)2.46081911
166cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.44453848
167barbed-end actin filament capping (GO:0051016)2.42026210
168positive regulation of keratinocyte differentiation (GO:0045618)2.38941674
169excretion (GO:0007588)2.38734345
170columnar/cuboidal epithelial cell development (GO:0002066)2.38534004
171membrane protein proteolysis (GO:0033619)2.37953293
172mammary gland alveolus development (GO:0060749)2.37482099
173regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.34878392
174negative regulation of interleukin-2 production (GO:0032703)2.33597693
175surfactant homeostasis (GO:0043129)13.8289411
176chemical homeostasis within a tissue (GO:0048875)11.3794251

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.97943208
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.88765387
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.77848353
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.69267583
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.68899619
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.46010271
7ESR2_21235772_ChIP-Seq_MCF-7_Human3.44367199
8* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse3.08669497
9* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.86817750
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.63456440
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.60240996
12CLOCK_20551151_ChIP-Seq_293T_Human2.59947348
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.59309369
14SOX2_20726797_ChIP-Seq_SW620_Human2.38462284
15* GATA4_25053715_ChIP-Seq_YYC3_Human2.37888717
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.37124639
17GATA1_22025678_ChIP-Seq_K562_Human2.25350708
18PPAR_26484153_Chip-Seq_NCI-H1993_Human2.25118458
19FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.23426500
20CDX2_20551321_ChIP-Seq_CACO-2_Human2.14300189
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.13515270
22SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.02371395
23FOXO3_23340844_ChIP-Seq_DLD1_Human2.02064344
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.96324257
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.91129780
26ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.83020682
27LXR_22158963_ChIP-Seq_LIVER_Mouse1.82169786
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.80652695
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.79487174
30* GATA6_25053715_ChIP-Seq_YYC3_Human1.67681133
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.65075629
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65035870
33PPARA_22158963_ChIP-Seq_LIVER_Mouse1.64648400
34* RUNX1_27514584_Chip-Seq_MCF-7_Human1.64383019
35AHR_22903824_ChIP-Seq_MCF-7_Human1.64335908
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.63195057
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.63195057
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.61796468
39* RACK7_27058665_Chip-Seq_MCF-7_Human1.58705236
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.51886763
41* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51096560
42P63_26484246_Chip-Seq_KERATINOCYTES_Human1.46477575
43SALL4_18804426_ChIP-ChIP_XEN_Mouse1.44491937
44GATA3_24758297_ChIP-Seq_MCF-7_Human1.43829646
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43742079
46ZNF263_19887448_ChIP-Seq_K562_Human1.43691709
47SOX9_24532713_ChIP-Seq_HFSC_Mouse1.43369484
48* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42638812
49* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.41345191
50* KLF5_25053715_ChIP-Seq_YYC3_Human1.40850176
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40604254
52* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39059973
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38271263
54SMC4_20622854_ChIP-Seq_HELA_Human1.37319341
55FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.34806271
56* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34511785
57TBX20_22328084_ChIP-Seq_HEART_Mouse1.30147113
58TBX20_22080862_ChIP-Seq_HEART_Mouse1.30147113
59CJUN_26792858_Chip-Seq_BT549_Human1.30145809
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29110310
61* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.26006960
62EP300_21415370_ChIP-Seq_HL-1_Mouse1.25748701
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22293496
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22266236
65FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22202068
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.21756618
67* SA1_27219007_Chip-Seq_ERYTHROID_Human1.20607293
68TP63_22573176_ChIP-Seq_HFKS_Human1.19645924
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19488413
70* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19461647
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18465100
72* CTCF_27219007_Chip-Seq_Bcells_Human1.18208340
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17941828
74ATF3_27146783_Chip-Seq_COLON_Human1.16660456
75JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16279694
76P68_20966046_ChIP-Seq_HELA_Human1.15524763
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.15461868
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14268213
79ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13084274
80ELF5_23300383_ChIP-Seq_T47D_Human1.10864346
81Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10803299
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10057474
83FOXA2_19822575_ChIP-Seq_HepG2_Human1.09774290
84TCF7_22412390_ChIP-Seq_EML_Mouse1.09712901
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07610650
86TP53_18474530_ChIP-ChIP_U2OS_Human1.04288470
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03850864
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.03435476
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.03266315
90EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02640628
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01140901
92FOXA1_25552417_ChIP-Seq_VCAP_Human1.00583096
93DROSHA_22980978_ChIP-Seq_HELA_Human1.00479373
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00185689
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99263535
96* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98764749
97* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98361744
98SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97663021
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97183009
100* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96768021
101TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96473911
102* KDM2B_26808549_Chip-Seq_DND41_Human0.95928595
103ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95784286
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95738024
105CREB1_26743006_Chip-Seq_LNCaP_Human0.95298429
106KDM2B_26808549_Chip-Seq_K562_Human0.93973662
107NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93869855
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93869855
109RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93389633
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93290228
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93275847
112SA1_27219007_Chip-Seq_Bcells_Human0.93156855
113MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92849359
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92825191
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92614906
116EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91100725
117JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90874270
118* ELK3_25401928_ChIP-Seq_HUVEC_Human0.90718047
119* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90270863
120ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89589295
121TP63_23658742_ChIP-Seq_EP156T_Human0.89275395
122NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88120631
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87927525
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86966917
125* LXR_22292898_ChIP-Seq_THP-1_Human0.86800869
126* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85276785
127TCF4_18268006_ChIP-ChIP_LS174T_Human0.82327685
128CHD1_26751641_Chip-Seq_LNCaP_Human0.81803175
129* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80543743
130NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79755106
131* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78405460

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog6.91494831
2MP0008004_abnormal_stomach_pH6.05699723
3MP0001958_emphysema4.16683714
4MP0010234_abnormal_vibrissa_follicle4.10302080
5* MP0001666_abnormal_nutrient_absorption3.44851397
6MP0008995_early_reproductive_senescence2.98199702
7MP0001881_abnormal_mammary_gland2.78932433
8MP0002138_abnormal_hepatobiliary_system2.76615031
9MP0005220_abnormal_exocrine_pancreas2.52604010
10MP0000537_abnormal_urethra_morphology2.43797527
11* MP0005083_abnormal_biliary_tract2.34768533
12MP0005365_abnormal_bile_salt2.28091699
13MP0004264_abnormal_extraembryonic_tissu2.23720404
14MP0009780_abnormal_chondrocyte_physiolo2.15640903
15MP0010368_abnormal_lymphatic_system2.10958883
16MP0000566_synostosis2.05708636
17MP0002295_abnormal_pulmonary_circulatio2.03208188
18MP0001177_atelectasis2.02612108
19MP0000678_abnormal_parathyroid_gland1.93753052
20MP0005084_abnormal_gallbladder_morpholo1.90708264
21MP0002133_abnormal_respiratory_system1.89644348
22MP0005388_respiratory_system_phenotype1.89644348
23* MP0001664_abnormal_digestion1.87610720
24MP0010678_abnormal_skin_adnexa1.84046391
25MP0006054_spinal_hemorrhage1.81311607
26MP0004272_abnormal_basement_membrane1.73244013
27MP0004043_abnormal_pH_regulation1.71966475
28MP0001873_stomach_inflammation1.68705672
29MP0003724_increased_susceptibility_to1.63148513
30MP0003300_gastrointestinal_ulcer1.59956332
31MP0002098_abnormal_vibrissa_morphology1.59814651
32MP0003705_abnormal_hypodermis_morpholog1.58355211
33MP0002254_reproductive_system_inflammat1.57460293
34MP0002796_impaired_skin_barrier1.53396842
35MP0002277_abnormal_respiratory_mucosa1.52871792
36MP0002139_abnormal_hepatobiliary_system1.51733877
37MP0000470_abnormal_stomach_morphology1.47028529
38MP0005408_hypopigmentation1.37753426
39MP0003566_abnormal_cell_adhesion1.37552678
40MP0001879_abnormal_lymphatic_vessel1.35774285
41MP0008875_abnormal_xenobiotic_pharmacok1.32671496
42MP0003191_abnormal_cellular_cholesterol1.32550564
43MP0003868_abnormal_feces_composition1.28997250
44MP0005076_abnormal_cell_differentiation1.27536641
45MP0003115_abnormal_respiratory_system1.26219172
46MP0002896_abnormal_bone_mineralization1.25843369
47MP0000383_abnormal_hair_follicle1.21412083
48MP0000467_abnormal_esophagus_morphology1.20310794
49MP0009384_cardiac_valve_regurgitation1.17957576
50MP0005503_abnormal_tendon_morphology1.14530318
51MP0003453_abnormal_keratinocyte_physiol1.14079647
52MP0001849_ear_inflammation1.08961293
53MP0002653_abnormal_ependyma_morphology1.08939233
54MP0005058_abnormal_lysosome_morphology1.08524682
55MP0003866_abnormal_defecation1.07899541
56* MP0002118_abnormal_lipid_homeostasis1.04383918
57MP0010771_integument_phenotype1.04051983
58MP0009643_abnormal_urine_homeostasis1.03583670
59MP0000477_abnormal_intestine_morphology1.01126141
60MP0002249_abnormal_larynx_morphology1.00747829
61* MP0000627_abnormal_mammary_gland0.99707898
62MP0005409_darkened_coat_color0.98558722
63MP0005165_increased_susceptibility_to0.98528213
64MP0002132_abnormal_respiratory_system0.97504364
65MP0000858_altered_metastatic_potential0.96755910
66MP0001542_abnormal_bone_strength0.95727131
67MP0009840_abnormal_foam_cell0.95232426
68MP0003091_abnormal_cell_migration0.95219112
69MP0009931_abnormal_skin_appearance0.94600727
70MP0005275_abnormal_skin_tensile0.93789897
71MP0005167_abnormal_blood-brain_barrier0.92646940
72MP0004185_abnormal_adipocyte_glucose0.91811364
73MP0001243_abnormal_dermal_layer0.89774340
74MP0005164_abnormal_response_to0.88920808
75MP0003941_abnormal_skin_development0.88800072
76MP0001175_abnormal_lung_morphology0.88687421
77MP0002234_abnormal_pharynx_morphology0.87507314
78MP0005023_abnormal_wound_healing0.86285155
79MP0001346_abnormal_lacrimal_gland0.85476404
80MP0004883_abnormal_blood_vessel0.85210577
81MP0000462_abnormal_digestive_system0.85177134
82MP0003045_fibrosis0.84155041
83MP0005666_abnormal_adipose_tissue0.83730338
84MP0003183_abnormal_peptide_metabolism0.83554789
85MP0010030_abnormal_orbit_morphology0.83161734
86MP0002166_altered_tumor_susceptibility0.80764060
87MP0000534_abnormal_ureter_morphology0.79007626
88MP0003279_aneurysm0.78803379
89MP0010329_abnormal_lipoprotein_level0.78521457
90MP0002877_abnormal_melanocyte_morpholog0.78104754
91MP0004019_abnormal_vitamin_homeostasis0.77968097
92MP0000579_abnormal_nail_morphology0.77043645
93MP0003936_abnormal_reproductive_system0.76651853
94MP0003959_abnormal_lean_body0.76354428
95MP0001851_eye_inflammation0.76116094
96MP0003638_abnormal_response/metabolism_0.74739736
97MP0000762_abnormal_tongue_morphology0.74217364
98MP0004858_abnormal_nervous_system0.73835192
99MP0008438_abnormal_cutaneous_collagen0.73749734
100MP0005501_abnormal_skin_physiology0.72948372
101MP0002282_abnormal_trachea_morphology0.72886093
102MP0005375_adipose_tissue_phenotype0.72694606
103MP0010352_gastrointestinal_tract_polyps0.71852941
104MP0002089_abnormal_postnatal_growth/wei0.71840401
105MP0003806_abnormal_nucleotide_metabolis0.71446373
106MP0001216_abnormal_epidermal_layer0.70960217
107MP0002060_abnormal_skin_morphology0.70876094
108MP0005166_decreased_susceptibility_to0.70245510
109MP0002168_other_aberrant_phenotype0.69971129
110MP0005451_abnormal_body_composition0.69221109
111MP0000490_abnormal_crypts_of0.67932908
112MP0000367_abnormal_coat/_hair0.67836483
113MP0002876_abnormal_thyroid_physiology0.67183293
114MP0000003_abnormal_adipose_tissue0.66994770
115MP0002136_abnormal_kidney_physiology0.66747132
116MP0002693_abnormal_pancreas_physiology0.66317719
117MP0010155_abnormal_intestine_physiology0.65177967
118MP0005381_digestive/alimentary_phenotyp0.64746712
119MP0001944_abnormal_pancreas_morphology0.64337186
120MP0001663_abnormal_digestive_system0.64154844
121MP0000377_abnormal_hair_follicle0.64128861
122MP0003186_abnormal_redox_activity0.64092714
123MP0002405_respiratory_system_inflammati0.63773035
124MP0002909_abnormal_adrenal_gland0.61994869
125MP0001765_abnormal_ion_homeostasis0.60675121
126MP0005248_abnormal_Harderian_gland0.60391857
127MP0004947_skin_inflammation0.59801305
128MP0003950_abnormal_plasma_membrane0.59549027
129MP0008961_abnormal_basal_metabolism0.57823296
130MP0001756_abnormal_urination0.57013391
131MP0003303_peritoneal_inflammation0.56076823
132MP0002135_abnormal_kidney_morphology0.55412008
133MP0003786_premature_aging0.54080344
134MP0005332_abnormal_amino_acid0.53853531
135MP0000681_abnormal_thyroid_gland0.53219573

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)5.62060222
2Onycholysis (HP:0001806)5.58958084
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.21748972
4Tachypnea (HP:0002789)4.96235636
5Respiratory distress (HP:0002098)4.90904444
6Chronic bronchitis (HP:0004469)4.62452159
7Right ventricular cardiomyopathy (HP:0011663)4.23765584
8Abnormal respiratory epithelium morphology (HP:0012253)4.19329056
9Abnormal respiratory motile cilium morphology (HP:0005938)4.19329056
10Abnormal respiratory motile cilium physiology (HP:0012261)4.17710682
11Absent/shortened dynein arms (HP:0200106)4.16143856
12Dynein arm defect of respiratory motile cilia (HP:0012255)4.16143856
13Abnormal ciliary motility (HP:0012262)3.91029649
14Rhinitis (HP:0012384)3.85368864
15Distal lower limb muscle weakness (HP:0009053)3.79409757
16* Tubulointerstitial fibrosis (HP:0005576)3.78943660
17Milia (HP:0001056)3.73114539
18Atrophic scars (HP:0001075)3.63385629
19Bronchiectasis (HP:0002110)3.56787894
20Abnormality of chloride homeostasis (HP:0011422)3.44193926
21Abnormality of the distal phalanges of the toes (HP:0010182)3.40279117
22Ulnar bowing (HP:0003031)3.39568091
23Hyperkalemia (HP:0002153)3.37166013
24Broad metatarsal (HP:0001783)3.35732494
25Fragile nails (HP:0001808)3.32238694
26Esophageal varix (HP:0002040)3.32071832
27Cervical subluxation (HP:0003308)3.19791088
28Decreased circulating renin level (HP:0003351)3.17658606
29Bronchomalacia (HP:0002780)3.14443979
30Short nail (HP:0001799)3.00034672
31* Renal salt wasting (HP:0000127)2.98837489
32Pustule (HP:0200039)2.95779931
33Hypoplasia of dental enamel (HP:0006297)2.92669913
34Micronodular cirrhosis (HP:0001413)2.87213293
35Neurofibrillary tangles (HP:0002185)2.83190599
36Stenosis of the external auditory canal (HP:0000402)2.77697820
37Premature skin wrinkling (HP:0100678)2.69829995
38Lip pit (HP:0100267)2.67422111
39Polycythemia (HP:0001901)2.67299952
40Synostosis involving the elbow (HP:0003938)2.63204702
41Humeroradial synostosis (HP:0003041)2.63204702
42Abnormality of the nasal mucosa (HP:0000433)2.60467971
43Plantar hyperkeratosis (HP:0007556)2.60005156
44Turricephaly (HP:0000262)2.59343052
45Visceral angiomatosis (HP:0100761)2.58904904
46Malnutrition (HP:0004395)2.58460726
47Hyperaldosteronism (HP:0000859)2.57595802
48Subacute progressive viral hepatitis (HP:0006572)2.56642388
49Steatorrhea (HP:0002570)2.56181178
50Abnormal hair laboratory examination (HP:0003328)2.55738673
51Abnormal pancreas size (HP:0012094)2.53708724
52Bowed forearm bones (HP:0003956)2.50834874
53Bowing of the arm (HP:0006488)2.50834874
54Stomach cancer (HP:0012126)2.48387590
55Curly hair (HP:0002212)2.46462792
56Broad face (HP:0000283)2.44683341
57Hemangiomatosis (HP:0007461)2.44033609
58Mucopolysacchariduria (HP:0008155)2.42823692
59Urinary glycosaminoglycan excretion (HP:0003541)2.42823692
60Atelectasis (HP:0100750)2.42744459
61Glomerulonephritis (HP:0000099)2.42600158
62Rectal prolapse (HP:0002035)2.41641555
63Neonatal respiratory distress (HP:0002643)2.40058068
64Distal upper limb amyotrophy (HP:0007149)2.39730678
65Upper limb amyotrophy (HP:0009129)2.39730678
66Cerebral inclusion bodies (HP:0100314)2.38247909
67Nephritis (HP:0000123)2.36042789
68Obstructive sleep apnea (HP:0002870)2.35817015
69Arterial tortuosity (HP:0005116)2.35005332
70Osteolytic defects of the phalanges of the hand (HP:0009771)2.32180219
71Osteolytic defects of the hand bones (HP:0009699)2.32180219
72Infertility (HP:0000789)2.31104804
73Vascular tortuosity (HP:0004948)2.29228665
74Hematochezia (HP:0002573)2.28843970
75Germ cell neoplasia (HP:0100728)2.26841207
76Pili torti (HP:0003777)2.26538747
77Shallow orbits (HP:0000586)2.25854629
78Exocrine pancreatic insufficiency (HP:0001738)2.22636419
79Thyroid-stimulating hormone excess (HP:0002925)2.22115754
80Systemic lupus erythematosus (HP:0002725)2.20626261
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19148362
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19148362
83Abnormality of polysaccharide metabolism (HP:0011012)2.19148362
84Male infertility (HP:0003251)2.16846965
85Thin bony cortex (HP:0002753)2.13869344
86Abnormality of renin-angiotensin system (HP:0000847)2.13501474
87Facial shape deformation (HP:0011334)2.13232494
88Potter facies (HP:0002009)2.13232494
89Dysostosis multiplex (HP:0000943)2.13081759
90Dehydration (HP:0001944)2.10616161
91Aplasia involving bones of the upper limbs (HP:0009823)2.09969411
92Aplasia of the phalanges of the hand (HP:0009802)2.09969411
93Aplasia involving bones of the extremities (HP:0009825)2.09969411
94Abnormality of monocarboxylic acid metabolism (HP:0010996)2.09293141
95Flattened epiphyses (HP:0003071)2.07035316
96Cerebral aneurysm (HP:0004944)2.06826903
97J-shaped sella turcica (HP:0002680)2.05691688
98Mildly elevated creatine phosphokinase (HP:0008180)2.05241587
99Spinal cord compression (HP:0002176)2.04179311
100* Tubulointerstitial abnormality (HP:0001969)2.03723250
101Abnormality of complement system (HP:0005339)2.03513627
102Complement deficiency (HP:0004431)2.02687548
103Buphthalmos (HP:0000557)2.02605327
104Abnormality of permanent molar morphology (HP:0011071)2.01553729
105Abnormality of the dental root (HP:0006486)2.01553729
106Taurodontia (HP:0000679)2.01553729
107Distal lower limb amyotrophy (HP:0008944)2.01365514
108Cortical dysplasia (HP:0002539)2.00185738
109Interstitial pulmonary disease (HP:0006530)11.6992196
110Abnormality of molar morphology (HP:0011070)1.99345729
111Abnormality of molar (HP:0011077)1.99345729
112Chronic otitis media (HP:0000389)1.98604167
113Premature rupture of membranes (HP:0001788)1.98043805
114Aortic aneurysm (HP:0004942)1.96450746
115Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95885396
116Abnormality of the dental pulp (HP:0006479)1.95745086
117Split foot (HP:0001839)1.95638138
118Progressive sensorineural hearing impairment (HP:0000408)1.95597786
119Chronic sinusitis (HP:0011109)1.95380549
120Fat malabsorption (HP:0002630)1.94244572
121Long toe (HP:0010511)1.93526813
122Hand muscle atrophy (HP:0009130)1.93314596
123Hypoplastic labia majora (HP:0000059)1.92776101
124Bell-shaped thorax (HP:0001591)1.91950236
125Abnormality of the gastric mucosa (HP:0004295)1.91338067
126Recurrent otitis media (HP:0000403)1.90806025
127Bronchitis (HP:0012387)1.90148620
128Breast carcinoma (HP:0003002)1.89471964
129Sparse lateral eyebrow (HP:0005338)1.89095038
130Flat acetabular roof (HP:0003180)1.88802792
131Protrusio acetabuli (HP:0003179)1.88514384
132Congenital sensorineural hearing impairment (HP:0008527)1.86809409
133Hypokalemic alkalosis (HP:0001949)1.85774276
134Glucose intolerance (HP:0000833)1.85470258
135Alopecia of scalp (HP:0002293)1.82941713
136Vascular calcification (HP:0004934)1.82859312
137Esophageal atresia (HP:0002032)1.82439498
138Diaphragmatic weakness (HP:0009113)1.82113397
139Goiter (HP:0000853)1.80927216
140Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.80792230
141Down-sloping shoulders (HP:0200021)1.79997845
142Abdominal distention (HP:0003270)1.78182255
143Severe short stature (HP:0003510)1.77586599
144Loss of speech (HP:0002371)1.77550581
145Nuclear cataract (HP:0100018)1.76859279
146Focal segmental glomerulosclerosis (HP:0000097)1.75196951
147Choanal stenosis (HP:0000452)1.74797985
148Cardiovascular calcification (HP:0011915)1.74155726
149Joint stiffness (HP:0001387)1.74092796
150Fragile skin (HP:0001030)1.72911217
151Congenital glaucoma (HP:0001087)1.71777181
152Nasal polyposis (HP:0100582)1.71770145
153Abnormality of sodium homeostasis (HP:0010931)1.71656845
154Abnormality of the 2nd finger (HP:0004100)1.71634207
155Hyponatremia (HP:0002902)1.70533990
156Lymphangioma (HP:0100764)1.70383078
157Abnormality of the intrinsic pathway (HP:0010989)1.69162179
158Abnormality of the labia majora (HP:0012881)1.67629157
159Abnormal hemoglobin (HP:0011902)1.67551914
160Autoamputation (HP:0001218)1.66966018
161Abnormality of nail color (HP:0100643)1.66895035
162Aneurysm (HP:0002617)1.63709200
163Amelogenesis imperfecta (HP:0000705)1.61766820
164Labial hypoplasia (HP:0000066)1.61636199
165Subcapsular cataract (HP:0000523)1.60759284
166Femoral bowing (HP:0002980)1.60718704
167Stridor (HP:0010307)1.58340086

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.73545210
2TRIB33.32881050
3MST43.15313450
4FGFR22.98807246
5ERN12.81243088
6LRRK22.72965286
7MAP3K32.58247937
8TGFBR22.55755493
9EPHB12.50307026
10BCKDK2.44026786
11STK242.42313522
12PKN22.35055353
13MST1R2.11118255
14RIPK12.11011144
15FER2.04658284
16MAP2K22.04089503
17PTK62.01523111
18SIK11.94246205
19PAK41.93401338
20MAP3K21.87083026
21LMTK21.82941232
22DAPK21.81840269
23EPHB21.78409311
24FRK1.78226220
25LATS11.67394301
26WNK41.59100043
27STK101.52456521
28CAMK1D1.50602117
29MAPK151.49515921
30EPHA31.47567409
31TIE11.44637517
32ILK1.41428660
33PTK21.36539905
34TESK11.32813185
35SMG11.31525128
36RPS6KB21.27031793
37MET1.25952966
38MAP3K61.18731519
39FGFR41.18475373
40ICK1.16507984
41STK391.14238924
42MAP2K11.13121465
43CDC42BPA1.11497304
44MAP2K31.03691521
45NTRK10.99555976
46CDK60.96702233
47MARK20.94146836
48MAP3K130.91405776
49CAMK1G0.90103846
50MYLK0.88454695
51TAOK10.86655834
52NEK90.83592639
53GSK3A0.82228477
54HIPK20.80426044
55RPS6KA20.80039630
56ERBB20.77018465
57CDK120.76910270
58IRAK30.76422881
59TRPM70.75780547
60MUSK0.75758906
61MAP3K90.75713612
62TAOK30.74418232
63DDR20.74046804
64GRK10.71127434
65MAPKAPK30.70696397
66MAP3K10.69649078
67FGFR30.69554514
68NEK60.68726537
69DMPK0.68561195
70NUAK10.66834407
71STK380.66547215
72PDGFRA0.66522327
73MAP3K110.65006272
74LATS20.64699873
75PRKD20.62878124
76KSR20.60884504
77ERBB30.59078792
78PDK20.58463936
79MAP2K60.58214389
80FGFR10.57510693
81EEF2K0.57185762
82BMX0.55409446
83MAP3K70.55123549
84PRKG20.54907552
85PRKCI0.54866213
86CHUK0.53508249
87TYK20.52250846
88MATK0.51838350
89STK38L0.50373138
90PRKD10.50224905
91DYRK1B0.50056214
92IRAK10.47529354
93TBK10.46775801
94RET0.46710366
95MAP3K140.46179759
96LIMK10.46048786
97MAPKAPK20.45590060
98EIF2AK30.45055933
99GRK60.45014025
100PIK3CA0.44978761
101STK30.44097995
102NME20.43538451
103SIK30.42183494
104CSK0.41908231
105MAP3K120.41770638
106PAK20.41059129
107PDPK10.39483442
108RPS6KL10.39078916
109RPS6KC10.39078916
110PDK30.36757328
111PDK40.36757328
112ABL20.34719167
113MTOR0.33741541
114EIF2AK10.32611252
115ERBB40.31206891
116NME10.30639955
117MAP3K80.30427300
118PRPF4B0.30338878
119TGFBR10.28110417
120MAPK70.27931077
121DAPK30.27136028
122RPS6KA60.26705206
123TAOK20.25959715
124PRKAA20.25836457
125* SRC0.25276058
126JAK10.23775789
127PIK3CG0.23239180
128CAMK2G0.23156854
129ROCK10.21878766
130TESK20.21712048
131IKBKE0.21362159
132PTK2B0.20853759
133PRKCZ0.20823226
134* PDGFRB0.20371113
135JAK20.20208258
136CDK70.18334145
137MAPK30.16683499

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049724.10178317
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.55545803
3Fatty acid biosynthesis_Homo sapiens_hsa000613.34037814
4Caffeine metabolism_Homo sapiens_hsa002323.19875753
5Fat digestion and absorption_Homo sapiens_hsa049753.10766197
6Protein digestion and absorption_Homo sapiens_hsa049742.87935712
7Phenylalanine metabolism_Homo sapiens_hsa003602.47207859
8Mineral absorption_Homo sapiens_hsa049782.38862973
9Other glycan degradation_Homo sapiens_hsa005112.21865812
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.13626255
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.12927698
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09850102
13Glutathione metabolism_Homo sapiens_hsa004801.82409257
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.81194642
15ECM-receptor interaction_Homo sapiens_hsa045121.79305006
16Adherens junction_Homo sapiens_hsa045201.77516111
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.68720422
18Tyrosine metabolism_Homo sapiens_hsa003501.68372663
19Tight junction_Homo sapiens_hsa045301.66973491
20Chemical carcinogenesis_Homo sapiens_hsa052041.66516344
21Glycerolipid metabolism_Homo sapiens_hsa005611.57649847
22Fructose and mannose metabolism_Homo sapiens_hsa000511.57182121
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.44680225
24Sphingolipid metabolism_Homo sapiens_hsa006001.43843057
25Bladder cancer_Homo sapiens_hsa052191.43020805
26Vitamin digestion and absorption_Homo sapiens_hsa049771.42041808
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.40191437
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.39885106
29Lysosome_Homo sapiens_hsa041421.38421876
30Propanoate metabolism_Homo sapiens_hsa006401.27924731
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23064031
32Gastric acid secretion_Homo sapiens_hsa049711.20951208
33Protein export_Homo sapiens_hsa030601.15361603
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13753486
35Renin-angiotensin system_Homo sapiens_hsa046141.13407307
36Vibrio cholerae infection_Homo sapiens_hsa051101.13174744
37Sulfur metabolism_Homo sapiens_hsa009201.11696064
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.08981874
39Hippo signaling pathway_Homo sapiens_hsa043901.07494842
40Fatty acid degradation_Homo sapiens_hsa000711.06956369
41Toxoplasmosis_Homo sapiens_hsa051451.06070464
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04941709
43Small cell lung cancer_Homo sapiens_hsa052221.04185738
44Steroid biosynthesis_Homo sapiens_hsa001001.02521022
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01571400
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01268864
47Histidine metabolism_Homo sapiens_hsa003401.01268544
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00539024
49Collecting duct acid secretion_Homo sapiens_hsa049661.00206705
50Focal adhesion_Homo sapiens_hsa045100.99988257
51Ether lipid metabolism_Homo sapiens_hsa005650.99955420
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99323049
53Complement and coagulation cascades_Homo sapiens_hsa046100.99205589
54Fatty acid metabolism_Homo sapiens_hsa012120.96603039
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95863602
56Amoebiasis_Homo sapiens_hsa051460.91069975
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88860635
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87196011
59Pertussis_Homo sapiens_hsa051330.82702701
60Hepatitis C_Homo sapiens_hsa051600.82569300
61Arginine biosynthesis_Homo sapiens_hsa002200.81934512
62Folate biosynthesis_Homo sapiens_hsa007900.81903180
63Endometrial cancer_Homo sapiens_hsa052130.80720197
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80062195
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79194399
66Starch and sucrose metabolism_Homo sapiens_hsa005000.78196888
67Thyroid cancer_Homo sapiens_hsa052160.77452967
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77164282
69Staphylococcus aureus infection_Homo sapiens_hsa051500.76754352
70Pancreatic cancer_Homo sapiens_hsa052120.76588583
71Proteoglycans in cancer_Homo sapiens_hsa052050.76193271
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75857582
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74543646
74N-Glycan biosynthesis_Homo sapiens_hsa005100.72844724
75Linoleic acid metabolism_Homo sapiens_hsa005910.71006468
76Prolactin signaling pathway_Homo sapiens_hsa049170.70879405
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.70700774
78Galactose metabolism_Homo sapiens_hsa000520.69695148
79Choline metabolism in cancer_Homo sapiens_hsa052310.66803651
80VEGF signaling pathway_Homo sapiens_hsa043700.65366011
81Phagosome_Homo sapiens_hsa041450.64954553
82Malaria_Homo sapiens_hsa051440.63118706
83Influenza A_Homo sapiens_hsa051640.62770012
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62565109
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62449980
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60801117
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60057772
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58927531
89Renal cell carcinoma_Homo sapiens_hsa052110.57796265
90Sulfur relay system_Homo sapiens_hsa041220.57756832
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57361066
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57018331
93Pyruvate metabolism_Homo sapiens_hsa006200.56760892
94Arachidonic acid metabolism_Homo sapiens_hsa005900.55275133
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.53885312
96TNF signaling pathway_Homo sapiens_hsa046680.51783105
97PPAR signaling pathway_Homo sapiens_hsa033200.51345857
98beta-Alanine metabolism_Homo sapiens_hsa004100.49173571
99Fatty acid elongation_Homo sapiens_hsa000620.48562306
100Endocytosis_Homo sapiens_hsa041440.48303357
101Notch signaling pathway_Homo sapiens_hsa043300.48061970
102Nitrogen metabolism_Homo sapiens_hsa009100.47208652
103Viral myocarditis_Homo sapiens_hsa054160.46130522
104Chronic myeloid leukemia_Homo sapiens_hsa052200.45966325
105Axon guidance_Homo sapiens_hsa043600.45746792
106Thyroid hormone synthesis_Homo sapiens_hsa049180.45725253
107Peroxisome_Homo sapiens_hsa041460.45275220
108Rap1 signaling pathway_Homo sapiens_hsa040150.44535683
109Arginine and proline metabolism_Homo sapiens_hsa003300.42485088
110Rheumatoid arthritis_Homo sapiens_hsa053230.42385258
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.41824570
112Insulin signaling pathway_Homo sapiens_hsa049100.41737178
113Selenocompound metabolism_Homo sapiens_hsa004500.41681872
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.41120682
115Retinol metabolism_Homo sapiens_hsa008300.40848556
116TGF-beta signaling pathway_Homo sapiens_hsa043500.40513411
117Salivary secretion_Homo sapiens_hsa049700.39052379
118Pathways in cancer_Homo sapiens_hsa052000.38674990
119Prostate cancer_Homo sapiens_hsa052150.38600903
120Pentose phosphate pathway_Homo sapiens_hsa000300.38162279
121Insulin resistance_Homo sapiens_hsa049310.37527046
122Bile secretion_Homo sapiens_hsa049760.36713405
123Acute myeloid leukemia_Homo sapiens_hsa052210.36595085
124Ovarian steroidogenesis_Homo sapiens_hsa049130.36564112
125Salmonella infection_Homo sapiens_hsa051320.36307322
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36189347
127ErbB signaling pathway_Homo sapiens_hsa040120.35023326
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34976135
129ABC transporters_Homo sapiens_hsa020100.34689743
130Legionellosis_Homo sapiens_hsa051340.34210866
131Estrogen signaling pathway_Homo sapiens_hsa049150.33500440

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