MUC12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane glycoprotein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces and have been implicated in epithelial renewal and differentiation. These glycoproteins also play a role in intracellular signaling. This protein is expressed on the apical membrane surface of epithelial cells that line the mucosal surfaces of many different tissues including the colon, pancreas, prostate, and uterus. The expression of this gene is downregulated in colorectal cancer tissue. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of podosome assembly (GO:0071801)9.42478754
2bundle of His cell to Purkinje myocyte communication (GO:0086069)7.35816882
3maintenance of gastrointestinal epithelium (GO:0030277)7.33578149
4auditory receptor cell differentiation (GO:0042491)6.71547847
5receptor recycling (GO:0001881)6.59720569
6labyrinthine layer development (GO:0060711)6.40150248
7striated muscle atrophy (GO:0014891)5.90054312
8regulation of cholesterol homeostasis (GO:2000188)5.85202311
9retrograde transport, vesicle recycling within Golgi (GO:0000301)5.59121720
10epithelial structure maintenance (GO:0010669)5.57688278
11dendritic cell chemotaxis (GO:0002407)5.56436735
12protein targeting to Golgi (GO:0000042)5.48978509
13muscle atrophy (GO:0014889)5.48369147
14negative regulation of anoikis (GO:2000811)5.44696907
15establishment of protein localization to Golgi (GO:0072600)5.41615801
16receptor catabolic process (GO:0032801)5.37184935
17skeletal muscle adaptation (GO:0043501)5.25009529
18receptor guanylyl cyclase signaling pathway (GO:0007168)5.24474752
19intestinal epithelial cell development (GO:0060576)5.16337466
20positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.91386843
21negative regulation of striated muscle cell differentiation (GO:0051154)4.85497047
22desmosome organization (GO:0002934)4.74628227
23vocalization behavior (GO:0071625)4.62253606
24nephron tubule morphogenesis (GO:0072078)4.58629312
25nephron epithelium morphogenesis (GO:0072088)4.58629312
26sperm capacitation (GO:0048240)4.50137430
27sulfate transmembrane transport (GO:1902358)4.37527024
28positive regulation of organelle assembly (GO:1902117)4.34189146
29dendritic cell migration (GO:0036336)4.32989259
30regulation of anoikis (GO:2000209)4.19655634
31* O-glycan processing (GO:0016266)4.17939297
32actin filament depolymerization (GO:0030042)4.11957609
33regulation of membrane protein ectodomain proteolysis (GO:0051043)4.10916829
34phospholipid homeostasis (GO:0055091)4.00792437
35protein localization to Golgi apparatus (GO:0034067)3.98236901
36macroautophagy (GO:0016236)3.93106161
37positive regulation of fatty acid beta-oxidation (GO:0032000)3.91003433
38hair cell differentiation (GO:0035315)3.90331354
39regulation of ARF GTPase activity (GO:0032312)3.85889310
40ventricular cardiac muscle cell action potential (GO:0086005)3.79299692
41lipid translocation (GO:0034204)3.72741789
42phospholipid translocation (GO:0045332)3.72741789
43membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.71716264
44regulation of endothelial cell chemotaxis (GO:2001026)3.66927086
45inner ear receptor cell differentiation (GO:0060113)3.65739488
46Golgi to endosome transport (GO:0006895)3.65029361
47sulfate transport (GO:0008272)3.57890485
48histone H3-K9 demethylation (GO:0033169)3.55501914
49cGMP biosynthetic process (GO:0006182)3.54393592
50interleukin-6-mediated signaling pathway (GO:0070102)3.54037135
51regulation of hexokinase activity (GO:1903299)3.53676303
52regulation of glucokinase activity (GO:0033131)3.53676303
53regulation of ARF protein signal transduction (GO:0032012)3.51412205
54skin morphogenesis (GO:0043589)3.44908350
55intra-Golgi vesicle-mediated transport (GO:0006891)3.43224828
56negative regulation of digestive system process (GO:0060457)3.43147908
57cellular response to epidermal growth factor stimulus (GO:0071364)3.40574032
58positive regulation of fatty acid oxidation (GO:0046321)3.36764634
59renal tubule morphogenesis (GO:0061333)3.35243559
60fucosylation (GO:0036065)3.35126152
61positive regulation of growth hormone secretion (GO:0060124)3.32053681
62growth hormone secretion (GO:0030252)3.27195978
63cardiac conduction (GO:0061337)3.24758037
64regulation of heart rate by cardiac conduction (GO:0086091)3.24202617
65membrane repolarization during action potential (GO:0086011)3.20726302
66epithelial cell-cell adhesion (GO:0090136)3.18870996
67positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.17214068
68regulation of growth hormone secretion (GO:0060123)3.17058418
69glomerular filtration (GO:0003094)3.15955883
70negative regulation of keratinocyte proliferation (GO:0010839)3.12234617
71histone H3-K36 demethylation (GO:0070544)3.09541269
72glucocorticoid biosynthetic process (GO:0006704)3.09146998
73transepithelial transport (GO:0070633)3.08221783
74sodium ion homeostasis (GO:0055078)3.01876968
75response to epidermal growth factor (GO:0070849)3.00698077
76L-fucose catabolic process (GO:0042355)2.97957202
77fucose catabolic process (GO:0019317)2.97957202
78L-fucose metabolic process (GO:0042354)2.97957202
79branching involved in mammary gland duct morphogenesis (GO:0060444)2.97767853
80extracellular matrix assembly (GO:0085029)2.95722136
81regulation of fatty acid beta-oxidation (GO:0031998)2.92085589
82hemidesmosome assembly (GO:0031581)2.91483674
83positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.84836636
84regulation of membrane lipid distribution (GO:0097035)2.84151642
85renal filtration (GO:0097205)2.82846164
86urea cycle (GO:0000050)2.81315393
87regulation of sister chromatid cohesion (GO:0007063)2.81161520
88multicellular organismal water homeostasis (GO:0050891)2.80968183
89intestinal absorption (GO:0050892)2.80733107
90cell communication involved in cardiac conduction (GO:0086065)2.80246318
91oligosaccharide biosynthetic process (GO:0009312)2.79548419
92coronary vasculature morphogenesis (GO:0060977)2.77708610
93bicarbonate transport (GO:0015701)2.77417607
94determination of adult lifespan (GO:0008340)2.75460450
95* protein O-linked glycosylation (GO:0006493)2.71404708
96negative regulation of catenin import into nucleus (GO:0035414)2.71366898
97regulation of water loss via skin (GO:0033561)2.71353139
98digestive system process (GO:0022600)2.70366219
99Arp2/3 complex-mediated actin nucleation (GO:0034314)2.69732397
100negative regulation of myotube differentiation (GO:0010832)10.2449690

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human5.32959144
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.68492104
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.60587030
4CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.38920751
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.06321268
6DROSHA_22980978_ChIP-Seq_HELA_Human2.99366013
7FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.97350067
8ESR1_15608294_ChIP-ChIP_MCF-7_Human2.59367591
9ZNF217_24962896_ChIP-Seq_MCF-7_Human2.47999192
10FOXO3_23340844_ChIP-Seq_DLD1_Human2.46866277
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.33968937
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.29086059
13TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.26558397
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.24020068
15SOX2_27498859_Chip-Seq_STOMACH_Mouse2.20370570
16GATA6_25053715_ChIP-Seq_YYC3_Human2.20126746
17FOXA2_19822575_ChIP-Seq_HepG2_Human2.13895530
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.10791132
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.06531203
20CTNNB1_20460455_ChIP-Seq_HCT116_Human2.05396099
21WDR5_24793694_ChIP-Seq_LNCAP_Human2.04299325
22ESR1_20079471_ChIP-ChIP_T-47D_Human2.01037952
23ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.00750066
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95688923
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95175256
26GATA4_25053715_ChIP-Seq_YYC3_Human1.93616951
27RUNX1_27514584_Chip-Seq_MCF-7_Human1.89461797
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.87532041
29TCF4_18268006_ChIP-ChIP_LS174T_Human1.87286656
30KLF5_25053715_ChIP-Seq_YYC3_Human1.85221719
31GBX2_23144817_ChIP-Seq_PC3_Human1.80641131
32ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.76070841
33NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.73868440
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73193697
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.71807127
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.70889914
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69829084
38CDX2_22108803_ChIP-Seq_LS180_Human1.67385809
39SOX9_24532713_ChIP-Seq_HFSC_Mouse1.62960356
40CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59596182
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.59329875
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58043977
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.57962345
44AHR_22903824_ChIP-Seq_MCF-7_Human1.52606902
45SOX2_20726797_ChIP-Seq_SW620_Human1.52133848
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51010015
47ER_23166858_ChIP-Seq_MCF-7_Human1.41651199
48TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41608336
49TP53_16413492_ChIP-PET_HCT116_Human1.39676919
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.36420268
51BCAT_22108803_ChIP-Seq_LS180_Human1.31601011
52TDRD3_21172665_ChIP-Seq_MCF-7_Human1.30569175
53LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29334751
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27234379
55SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27234379
56GATA1_22025678_ChIP-Seq_K562_Human1.26790742
57* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26579970
58ISL1_27105846_Chip-Seq_CPCs_Mouse1.26502596
59HNF4A_19822575_ChIP-Seq_HepG2_Human1.21601135
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21461360
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15459728
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14482216
63IRF8_22096565_ChIP-ChIP_GC-B_Human1.14346259
64FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13378826
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10892464
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.09638407
67CJUN_26792858_Chip-Seq_BT549_Human1.08871016
68TCF4_22108803_ChIP-Seq_LS180_Human1.08675971
69* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07898044
70SMAD3_21741376_ChIP-Seq_HESCs_Human1.06208197
71FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04569821
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03354233
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02252977
74SMAD4_21799915_ChIP-Seq_A2780_Human1.00664725
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99458332
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98675844
77GF1_26923725_Chip-Seq_HPCs_Mouse0.95592153
78TP63_22573176_ChIP-Seq_HFKS_Human0.92014315
79WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91645947
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91309346
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90092166
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89526817
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88801099
84NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88801099
85PIAS1_25552417_ChIP-Seq_VCAP_Human0.88574580
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88332464
87TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87940370
88YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87790732
89AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86720845
90TCF4_23295773_ChIP-Seq_U87_Human0.86384390
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86184934
92* SPI1_23127762_ChIP-Seq_K562_Human0.83661008
93STAT3_23295773_ChIP-Seq_U87_Human0.83068445
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.82309840
95JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81999712
96FOXA1_25552417_ChIP-Seq_VCAP_Human0.81716434
97AR_19668381_ChIP-Seq_PC3_Human0.81111280
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79507112
99LXR_22158963_ChIP-Seq_LIVER_Mouse0.79245158
100NFIB_24661679_ChIP-Seq_LUNG_Mouse0.77904971

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.91692024
2MP0002822_catalepsy4.41954413
3MP0003866_abnormal_defecation3.77654886
4MP0004043_abnormal_pH_regulation3.51498030
5MP0004264_abnormal_extraembryonic_tissu3.34091154
6MP0000462_abnormal_digestive_system3.29383897
7MP0003283_abnormal_digestive_organ3.13085537
8MP0008438_abnormal_cutaneous_collagen2.83106879
9MP0001485_abnormal_pinna_reflex2.56074484
10MP0001664_abnormal_digestion2.51600095
11MP0003183_abnormal_peptide_metabolism2.46493768
12MP0005076_abnormal_cell_differentiation2.41674602
13MP0003045_fibrosis2.36223274
14MP0005409_darkened_coat_color2.35846183
15MP0001765_abnormal_ion_homeostasis2.22101462
16MP0002139_abnormal_hepatobiliary_system2.21475906
17MP0000465_gastrointestinal_hemorrhage2.05377399
18MP0003879_abnormal_hair_cell2.00741574
19MP0005257_abnormal_intraocular_pressure1.99831043
20MP0005275_abnormal_skin_tensile1.99534949
21MP0010352_gastrointestinal_tract_polyps1.96339303
22MP0003868_abnormal_feces_composition1.95504388
23MP0000566_synostosis1.93118671
24MP0000537_abnormal_urethra_morphology1.91398816
25MP0000762_abnormal_tongue_morphology1.88585747
26MP0000477_abnormal_intestine_morphology1.83269032
27MP0010678_abnormal_skin_adnexa1.78622162
28MP0005023_abnormal_wound_healing1.77758980
29MP0003300_gastrointestinal_ulcer1.71938663
30MP0005381_digestive/alimentary_phenotyp1.70828565
31MP0002098_abnormal_vibrissa_morphology1.64721901
32MP0004147_increased_porphyrin_level1.57966183
33MP0004084_abnormal_cardiac_muscle1.55690197
34MP0002060_abnormal_skin_morphology1.54294301
35MP0001270_distended_abdomen1.53036261
36MP0002896_abnormal_bone_mineralization1.52497767
37MP0010307_abnormal_tumor_latency1.51456552
38MP0001666_abnormal_nutrient_absorption1.50693644
39MP0003252_abnormal_bile_duct1.41526368
40MP0003315_abnormal_perineum_morphology1.36490556
41MP0000733_abnormal_muscle_development1.36059947
42MP0010155_abnormal_intestine_physiology1.35532183
43MP0008004_abnormal_stomach_pH1.35089315
44MP0000538_abnormal_urinary_bladder1.34596981
45MP0000383_abnormal_hair_follicle1.33417771
46MP0005365_abnormal_bile_salt1.33094958
47MP0001756_abnormal_urination1.32564695
48MP0005670_abnormal_white_adipose1.31775172
49MP0001663_abnormal_digestive_system1.30750450
50MP0003279_aneurysm1.30648220
51MP0003943_abnormal_hepatobiliary_system1.28833727
52MP0003091_abnormal_cell_migration1.28778961
53MP0000579_abnormal_nail_morphology1.24967586
54MP0000470_abnormal_stomach_morphology1.17303873
55MP0002796_impaired_skin_barrier1.16238189
56MP0003566_abnormal_cell_adhesion1.13510994
57MP0005503_abnormal_tendon_morphology1.13027315
58MP0003705_abnormal_hypodermis_morpholog1.12063764
59MP0005636_abnormal_mineral_homeostasis1.08010481
60MP0001849_ear_inflammation1.04363699
61MP0000230_abnormal_systemic_arterial1.04319626
62MP0004036_abnormal_muscle_relaxation1.03767764
63MP0000432_abnormal_head_morphology1.00688495
64MP0002168_other_aberrant_phenotype1.00346989
65MP0002163_abnormal_gland_morphology0.97599206
66MP0000428_abnormal_craniofacial_morphol0.97133463
67MP0005310_abnormal_salivary_gland0.96401499
68MP0005408_hypopigmentation0.95480238
69MP0002127_abnormal_cardiovascular_syste0.93457247
70MP0003937_abnormal_limbs/digits/tail_de0.92919474
71MP0005058_abnormal_lysosome_morphology0.92870047
72MP0001216_abnormal_epidermal_layer0.87656901
73MP0010386_abnormal_urinary_bladder0.86765403
74MP0000490_abnormal_crypts_of0.85454976
75MP0002132_abnormal_respiratory_system0.84297719
76MP0003693_abnormal_embryo_hatching0.81930121
77MP0000747_muscle_weakness0.81255615
78MP0009384_cardiac_valve_regurgitation0.80405293
79MP0005085_abnormal_gallbladder_physiolo0.78119834
80MP0002249_abnormal_larynx_morphology0.76527040
81MP0002138_abnormal_hepatobiliary_system0.75640728
82MP0005448_abnormal_energy_balance0.75416657
83MP0000627_abnormal_mammary_gland0.73573150
84MP0002009_preneoplasia0.72549978
85MP0005386_behavior/neurological_phenoty0.70356867
86MP0004924_abnormal_behavior0.70356867
87MP0005083_abnormal_biliary_tract0.69642848
88MP0000377_abnormal_hair_follicle0.68571266
89MP0002086_abnormal_extraembryonic_tissu0.65431087
90MP0002111_abnormal_tail_morphology0.64494488
91MP0002166_altered_tumor_susceptibility0.64337840
92MP0003453_abnormal_keratinocyte_physiol0.64092350
93MP0005187_abnormal_penis_morphology0.63058097
94MP0008872_abnormal_physiological_respon0.60298066
95MP0001730_embryonic_growth_arrest0.58443521
96MP0008775_abnormal_heart_ventricle0.57657994
97MP0002136_abnormal_kidney_physiology0.57301576
98MP0010368_abnormal_lymphatic_system0.57186322
99MP0002269_muscular_atrophy0.56511035
100MP0005621_abnormal_cell_physiology0.55499425

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)7.61332603
2Abnormality of the fingertips (HP:0001211)6.86972015
3Abnormality of chloride homeostasis (HP:0011422)5.94567353
4Ileus (HP:0002595)5.87724361
5Hyperkalemia (HP:0002153)5.15568363
6Decreased circulating renin level (HP:0003351)4.55295143
7Right ventricular cardiomyopathy (HP:0011663)4.53966630
8Abnormality of renin-angiotensin system (HP:0000847)4.42660690
9Abnormality of the nasal septum (HP:0000419)4.24138125
10Heterotopia (HP:0002282)4.09548085
11Abnormality of the distal phalanx of the thumb (HP:0009617)4.06456607
12Chronic diarrhea (HP:0002028)3.83297067
13Tetraparesis (HP:0002273)3.76963354
14Autoimmune hemolytic anemia (HP:0001890)3.74286428
15Neonatal short-limb short stature (HP:0008921)3.62417899
16Colitis (HP:0002583)3.58057381
17Hyperaldosteronism (HP:0000859)3.55620573
18IgM deficiency (HP:0002850)3.40337669
19Mildly elevated creatine phosphokinase (HP:0008180)3.40050321
20Abnormality of the phalanges of the hallux (HP:0010057)3.34955985
21Metabolic alkalosis (HP:0200114)3.28096866
22Aortic aneurysm (HP:0004942)3.17319134
23Fragile skin (HP:0001030)3.15621332
24Inflammation of the large intestine (HP:0002037)3.10944619
25Abnormality of the 1st metacarpal (HP:0010009)3.04668124
26Malnutrition (HP:0004395)3.00218357
27Abnormality of small intestinal villus morphology (HP:0011472)3.00058338
28Villous atrophy (HP:0011473)3.00058338
29Congenital sensorineural hearing impairment (HP:0008527)2.95372340
30Gastrointestinal inflammation (HP:0004386)2.92832922
31Progressive sensorineural hearing impairment (HP:0000408)2.89387908
32Flat acetabular roof (HP:0003180)2.80943894
33Abnormality of potassium homeostasis (HP:0011042)2.80002625
34Abnormality of the gastric mucosa (HP:0004295)2.79949583
35Hyponatremia (HP:0002902)2.77570994
36Cerebral aneurysm (HP:0004944)2.70071125
37Hemorrhage of the eye (HP:0011885)2.64492551
38Abnormal biliary tract morphology (HP:0012440)2.62172651
39Aortic dissection (HP:0002647)2.57604394
40Short phalanx of the thumb (HP:0009660)2.44557511
41Long eyelashes (HP:0000527)2.40915228
42Distal upper limb amyotrophy (HP:0007149)2.40058443
43Upper limb amyotrophy (HP:0009129)2.40058443
44Abnormality of the right ventricle (HP:0001707)2.38083601
45Intrahepatic cholestasis (HP:0001406)2.37104322
46Atrophic scars (HP:0001075)2.31886315
47Abnormality of monocarboxylic acid metabolism (HP:0010996)2.28618841
48Spinal muscular atrophy (HP:0007269)2.27366217
49Hyperacusis (HP:0010780)2.24409962
50Aneurysm (HP:0002617)2.23024894
51Distal lower limb amyotrophy (HP:0008944)2.22619062
52Narrow palate (HP:0000189)2.19540263
53Broad face (HP:0000283)2.10043091
54Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.05688771
55IgA deficiency (HP:0002720)2.04405638
56Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.03307447
57Abnormality of the aortic arch (HP:0012303)2.02781714
58Rectal prolapse (HP:0002035)2.00559412
59Gastrointestinal stroma tumor (HP:0100723)1.99839667
60Flared iliac wings (HP:0002869)1.98632820
61Pili torti (HP:0003777)1.96709208
62Abnormal hair whorl (HP:0010721)1.95993758
63Renovascular hypertension (HP:0100817)1.95716479
64Gastrointestinal dysmotility (HP:0002579)1.93184780
65Akinesia (HP:0002304)1.92676887
66Alkalosis (HP:0001948)1.91979087
67Abnormality of femoral epiphyses (HP:0006499)1.91774217
68Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.91774217
69Biliary tract neoplasm (HP:0100574)1.90684924
70Poikiloderma (HP:0001029)1.89890774
71Abnormality of the vitamin B12 metabolism (HP:0004341)1.87971801
72Abnormality of the epiphysis of the femoral head (HP:0010574)1.87675038
73Self-mutilation (HP:0000742)1.81747437
74Abnormality of sodium homeostasis (HP:0010931)1.81612308
75Abnormal hair laboratory examination (HP:0003328)1.79486909
76Natal tooth (HP:0000695)1.77938887
77Dehydration (HP:0001944)1.76878698
78Bowel diverticulosis (HP:0005222)1.76581702
79Tibial bowing (HP:0002982)1.76523351
80Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.76072755
81Short middle phalanx of finger (HP:0005819)1.75716061
82Hypoplastic iliac wings (HP:0002866)1.74564805
83Bilateral sensorineural hearing impairment (HP:0008619)1.73353694
84Urethral obstruction (HP:0000796)1.72344340
85Hoarse voice (HP:0001609)1.71679973
86Progressive hearing impairment (HP:0001730)1.70938932
87Trismus (HP:0000211)1.70484443
88Emphysema (HP:0002097)1.70030412
89Impulsivity (HP:0100710)1.69102096
90Abnormality of the preputium (HP:0100587)1.66655142
91Abnormality of incisor morphology (HP:0011063)1.66108009
92Abnormality of vitamin B metabolism (HP:0004340)1.65468280
93Oligodontia (HP:0000677)1.64097919
94Abnormality of vitamin metabolism (HP:0100508)1.64007652
95Abnormality of the femoral head (HP:0003368)1.63751858
96Abdominal distention (HP:0003270)1.63027919
97Aortic regurgitation (HP:0001659)1.63005214
98Premature ovarian failure (HP:0008209)1.61141202
99Abnormality of dentin (HP:0010299)1.59230743
100Abnormality of the columella (HP:0009929)1.59010137

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R7.64050866
2LMTK27.14349575
3WNK45.95865811
4MET5.74897814
5STK394.07044090
6WNK12.47679188
7EPHA22.25623312
8OXSR12.18742525
9PIK3CA1.99868691
10BLK1.94057761
11PBK1.93056443
12NME11.90879950
13CDK121.79948449
14CAMK1D1.75807015
15RIPK11.63428080
16ACVR1B1.54917896
17CAMK1G1.48395005
18CASK1.38305020
19ERBB21.35474589
20PRKG21.27933250
21STK241.26674097
22FGFR41.25157093
23ICK0.98219009
24PRKAA20.91048828
25EPHA30.82843719
26MAPK110.81929453
27PDGFRB0.78579585
28TRPM70.78138349
29CDC42BPA0.74937008
30PDGFRA0.69345652
31EPHB20.68234866
32MTOR0.64752818
33MAP2K60.61713652
34NEK20.61676745
35MAP3K130.59950011
36CHUK0.59208338
37PRKAA10.58659038
38MAP3K70.55603979
39SGK10.55486295
40NLK0.53103046
41MAPKAPK30.52471924
42FGFR30.49229978
43TNIK0.49010700
44NEK60.47874684
45FER0.45930590
46PHKG10.45693091
47PHKG20.45693091
48CAMK40.44854514
49CDK60.43622605
50TAOK10.43608944
51PTK20.41767787
52EPHB10.39703182
53MARK20.39307960
54TRIB30.37570481
55ERN10.36279530
56PAK30.35639254
57SIK10.34965284
58RPS6KA30.33783234
59MYLK0.33246752
60LATS10.31912980
61BMX0.31745221
62PTK60.30872352
63AKT30.29840009
64PRKD20.29411633
65CDK90.29128129
66YES10.29056582
67PRKDC0.28197399
68PRKCH0.27234224
69RPS6KA20.25185091
70RET0.24630252
71MAPK140.24137865
72TTN0.23658792
73STK38L0.23031177
74CSF1R0.22448859
75EEF2K0.22074394
76CHEK10.21393709
77FGFR20.21300713
78GSK3B0.20661070
79ROCK10.19904658
80DDR20.19638122
81MAPK10.19444095
82SRC0.18525401
83RPS6KC10.17279154
84RPS6KL10.17279154
85FRK0.16405614
86SCYL20.16292340
87CSNK1A10.15296012
88PRKCA0.14943465
89CDK20.14764585
90PRKCZ0.14738369
91CSNK1E0.14618889
92RPS6KA60.14291355
93MAPK30.13415545
94PRKCI0.12995258
95PDPK10.12384227
96RPS6KB20.12005251
97FYN0.11950857
98MKNK10.11923288
99MKNK20.11209134
100CAMK2D0.10738761

Predicted pathways (KEGG)

RankGene SetZ-score
1Progesterone-mediated oocyte maturation_Homo sapiens_hsa049143.71459716
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.71421282
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.66046403
4Oocyte meiosis_Homo sapiens_hsa041142.56867849
5Nitrogen metabolism_Homo sapiens_hsa009102.40529687
6Other glycan degradation_Homo sapiens_hsa005112.35823323
7Mineral absorption_Homo sapiens_hsa049782.35168217
8Adherens junction_Homo sapiens_hsa045202.32435018
9Pancreatic secretion_Homo sapiens_hsa049722.25743759
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.11105746
11Tight junction_Homo sapiens_hsa045302.05914261
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.00648554
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.00198450
14Sulfur metabolism_Homo sapiens_hsa009201.98284997
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.84515497
16Lysine degradation_Homo sapiens_hsa003101.81673170
17Notch signaling pathway_Homo sapiens_hsa043301.70166191
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63098663
19Phosphatidylinositol signaling system_Homo sapiens_hsa040701.62678901
20Thyroid hormone signaling pathway_Homo sapiens_hsa049191.52653875
21Inositol phosphate metabolism_Homo sapiens_hsa005621.51894498
22Dorso-ventral axis formation_Homo sapiens_hsa043201.45782454
23Protein digestion and absorption_Homo sapiens_hsa049741.38454882
24ABC transporters_Homo sapiens_hsa020101.25996425
25ECM-receptor interaction_Homo sapiens_hsa045121.25674569
26Gastric acid secretion_Homo sapiens_hsa049711.22496342
27Insulin secretion_Homo sapiens_hsa049111.20414635
28Fructose and mannose metabolism_Homo sapiens_hsa000511.18213040
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17069746
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16910965
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16894445
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.16852825
33Arginine biosynthesis_Homo sapiens_hsa002201.16371432
34Bile secretion_Homo sapiens_hsa049761.13039974
35Thyroid hormone synthesis_Homo sapiens_hsa049181.11347712
36Glucagon signaling pathway_Homo sapiens_hsa049221.09323397
37Renin secretion_Homo sapiens_hsa049241.06739166
38Vibrio cholerae infection_Homo sapiens_hsa051101.06643877
39Endometrial cancer_Homo sapiens_hsa052131.05808807
40Salivary secretion_Homo sapiens_hsa049701.04390842
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.03774581
42PPAR signaling pathway_Homo sapiens_hsa033201.01424484
43Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99932416
44Long-term potentiation_Homo sapiens_hsa047200.99296757
45Choline metabolism in cancer_Homo sapiens_hsa052310.98117617
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.96100363
47African trypanosomiasis_Homo sapiens_hsa051430.95420504
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94729960
49Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91205430
50Starch and sucrose metabolism_Homo sapiens_hsa005000.88915930
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86349638
52Amoebiasis_Homo sapiens_hsa051460.85984780
53Histidine metabolism_Homo sapiens_hsa003400.84146134
54Renal cell carcinoma_Homo sapiens_hsa052110.83336247
55GnRH signaling pathway_Homo sapiens_hsa049120.82429268
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77928187
57Glycerolipid metabolism_Homo sapiens_hsa005610.76435026
58Focal adhesion_Homo sapiens_hsa045100.75245737
59Retinol metabolism_Homo sapiens_hsa008300.73191155
60Taste transduction_Homo sapiens_hsa047420.73046483
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.69276809
62Propanoate metabolism_Homo sapiens_hsa006400.69042876
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65750039
64Thyroid cancer_Homo sapiens_hsa052160.65043752
65Fatty acid biosynthesis_Homo sapiens_hsa000610.62508553
66Insulin resistance_Homo sapiens_hsa049310.61891374
67Platelet activation_Homo sapiens_hsa046110.61224614
68ErbB signaling pathway_Homo sapiens_hsa040120.60489076
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.59916663
70Gap junction_Homo sapiens_hsa045400.57347032
71Caffeine metabolism_Homo sapiens_hsa002320.55136617
72Endocytosis_Homo sapiens_hsa041440.51728589
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.51238119
74Salmonella infection_Homo sapiens_hsa051320.51111390
75MicroRNAs in cancer_Homo sapiens_hsa052060.49228332
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47795499
77Proteoglycans in cancer_Homo sapiens_hsa052050.45977975
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.45933174
79HIF-1 signaling pathway_Homo sapiens_hsa040660.44821962
80Fatty acid degradation_Homo sapiens_hsa000710.44619293
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44407656
82Long-term depression_Homo sapiens_hsa047300.43793275
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42324467
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41012188
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39429826
86Dilated cardiomyopathy_Homo sapiens_hsa054140.38227061
87Staphylococcus aureus infection_Homo sapiens_hsa051500.37456670
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36697224
89Fat digestion and absorption_Homo sapiens_hsa049750.35220204
90Type II diabetes mellitus_Homo sapiens_hsa049300.34292769
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31776244
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30555315
93cAMP signaling pathway_Homo sapiens_hsa040240.29695282
94Renin-angiotensin system_Homo sapiens_hsa046140.29335514
95Insulin signaling pathway_Homo sapiens_hsa049100.29113480
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.28806580
97Olfactory transduction_Homo sapiens_hsa047400.28403373
98AMPK signaling pathway_Homo sapiens_hsa041520.26268545
99Chemical carcinogenesis_Homo sapiens_hsa052040.24913708
100Basal cell carcinoma_Homo sapiens_hsa052170.24786140

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