MUC16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)8.68882487
2ethanol metabolic process (GO:0006067)8.66255861
3renal absorption (GO:0070293)8.07596055
4left/right pattern formation (GO:0060972)7.47988020
5regulation of cilium movement (GO:0003352)6.31397386
6left/right axis specification (GO:0070986)6.21794139
7diterpenoid biosynthetic process (GO:0016102)6.06159713
8ventricular system development (GO:0021591)6.05860959
9activation of MAPKKK activity (GO:0000185)5.71265993
10negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)5.61156959
11cardiovascular system development (GO:0072358)5.60897808
12microtubule bundle formation (GO:0001578)5.58255150
13cilium or flagellum-dependent cell motility (GO:0001539)5.43614365
14uronic acid metabolic process (GO:0006063)5.37060522
15glucuronate metabolic process (GO:0019585)5.37060522
16fusion of sperm to egg plasma membrane (GO:0007342)5.29996974
17cell wall macromolecule catabolic process (GO:0016998)5.13628560
18cell wall macromolecule metabolic process (GO:0044036)5.13628560
19antibacterial humoral response (GO:0019731)5.08415628
20desmosome organization (GO:0002934)5.04175557
21extracellular negative regulation of signal transduction (GO:1900116)4.89793263
22extracellular regulation of signal transduction (GO:1900115)4.89793263
23regulation of female gonad development (GO:2000194)4.79628101
24intraciliary transport (GO:0042073)4.78714633
25multicellular organismal water homeostasis (GO:0050891)4.77442899
26cilium organization (GO:0044782)4.75411803
27negative regulation of epidermal cell differentiation (GO:0045605)4.67737209
28antimicrobial humoral response (GO:0019730)4.65512615
29cilium assembly (GO:0042384)4.57361894
30multicellular organism reproduction (GO:0032504)4.55027632
31negative regulation of complement activation (GO:0045916)4.53992102
32glomerular epithelial cell development (GO:0072310)4.42143965
33phenylpropanoid metabolic process (GO:0009698)4.32258469
34xenobiotic catabolic process (GO:0042178)4.26072662
35regulation of interleukin-5 production (GO:0032674)4.24785760
36L-ascorbic acid metabolic process (GO:0019852)4.21173068
37establishment of apical/basal cell polarity (GO:0035089)4.16578935
38lung epithelium development (GO:0060428)4.11431559
39microtubule-based movement (GO:0007018)4.09514067
40bundle of His cell to Purkinje myocyte communication (GO:0086069)4.01039038
41sulfur amino acid catabolic process (GO:0000098)4.00236854
42water homeostasis (GO:0030104)4.00069071
43terpenoid biosynthetic process (GO:0016114)3.98620471
44plasma membrane fusion (GO:0045026)3.97039874
45negative regulation of protein activation cascade (GO:2000258)3.89668531
46acrosome assembly (GO:0001675)3.83568513
47sperm-egg recognition (GO:0035036)3.82924543
48retinol metabolic process (GO:0042572)3.82050026
49regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.78720256
50response to xenobiotic stimulus (GO:0009410)3.77179392
51retinoic acid metabolic process (GO:0042573)3.73137154
52cellular glucuronidation (GO:0052695)3.69761850
53* O-glycan processing (GO:0016266)3.69476045
54lateral ventricle development (GO:0021670)3.67306836
55cellular component assembly involved in morphogenesis (GO:0010927)3.67166129
56establishment of planar polarity (GO:0001736)3.65089456
57establishment of tissue polarity (GO:0007164)3.65089456
58regulation of keratinocyte proliferation (GO:0010837)3.64330387
59centriole assembly (GO:0098534)3.63421423
60negative regulation of epidermis development (GO:0045683)3.62019543
61protein localization to cilium (GO:0061512)3.60619753
62axonemal dynein complex assembly (GO:0070286)3.59442801
63regulation of interleukin-13 production (GO:0032656)3.57727514
64reproduction (GO:0000003)3.53816350
65cilium movement (GO:0003341)3.53104332
66regulation of microtubule-based movement (GO:0060632)3.51448914
67negative regulation of T cell differentiation in thymus (GO:0033085)3.51402883
68cell projection assembly (GO:0030031)3.49169609
69lateral sprouting from an epithelium (GO:0060601)3.49050753
70positive regulation of glycolytic process (GO:0045821)3.47788977
71positive regulation of tolerance induction (GO:0002645)3.45315496
72apical protein localization (GO:0045176)3.42334039
73establishment or maintenance of monopolar cell polarity (GO:0061339)3.42006001
74establishment of monopolar cell polarity (GO:0061162)3.42006001
75folic acid transport (GO:0015884)3.37740056
76cilium morphogenesis (GO:0060271)3.37720878
77regulation of lipoprotein metabolic process (GO:0050746)3.36847296
78sperm motility (GO:0030317)3.36628219
79regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.36107657
80endocardial cushion morphogenesis (GO:0003203)3.35264153
81cell-cell recognition (GO:0009988)3.31323998
82one-carbon compound transport (GO:0019755)3.30269748
83fatty acid oxidation (GO:0019395)3.29590071
84Notch signaling involved in heart development (GO:0061314)3.29273009
85calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.28876897
86positive regulation of coagulation (GO:0050820)3.27347322
87tolerance induction (GO:0002507)3.27331961
88hemidesmosome assembly (GO:0031581)3.27246624
89excretion (GO:0007588)3.26924854
90lymphangiogenesis (GO:0001946)3.25452055
91hypotonic response (GO:0006971)3.22289545
92lipid oxidation (GO:0034440)3.22007174
93regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.21836560
94sperm capacitation (GO:0048240)3.20806154
95pyrimidine-containing compound transmembrane transport (GO:0072531)3.20305302
96cytoplasmic microtubule organization (GO:0031122)3.19792120
97binding of sperm to zona pellucida (GO:0007339)3.19724897
98amyloid precursor protein catabolic process (GO:0042987)3.15475233
99striated muscle atrophy (GO:0014891)3.13274796
100primary alcohol metabolic process (GO:0034308)3.10701059
101positive regulation of p38MAPK cascade (GO:1900745)3.04884099
102aldehyde catabolic process (GO:0046185)3.03416810
103positive regulation of smooth muscle cell migration (GO:0014911)3.02109521
104positive regulation of wound healing (GO:0090303)3.01284001
105regulation of germinal center formation (GO:0002634)3.01165294
106negative regulation of immunoglobulin mediated immune response (GO:0002890)3.00994907
107negative regulation of B cell mediated immunity (GO:0002713)3.00994907
108negative regulation of humoral immune response (GO:0002921)2.99911559
109regulation of keratinocyte differentiation (GO:0045616)2.98553216
110positive regulation of steroid biosynthetic process (GO:0010893)2.96890663
111positive regulation of smoothened signaling pathway (GO:0045880)2.95953210
112epithelial cilium movement (GO:0003351)2.95786523
113negative regulation of lipase activity (GO:0060192)2.93808430
114regulation of cholesterol biosynthetic process (GO:0045540)2.93664104
115negative regulation of digestive system process (GO:0060457)2.93049251
116microtubule depolymerization (GO:0007019)2.93040073
117lung vasculature development (GO:0060426)2.92968772
118positive regulation of hemostasis (GO:1900048)2.92023958
119positive regulation of blood coagulation (GO:0030194)2.92023958
120extracellular fibril organization (GO:0043206)2.91908626
121prostaglandin metabolic process (GO:0006693)2.91373528
122prostanoid metabolic process (GO:0006692)2.91373528
123metanephric mesenchyme development (GO:0072075)2.88338206
124low-density lipoprotein particle clearance (GO:0034383)2.88149940
125phospholipid homeostasis (GO:0055091)2.88036120
126cytoskeletal anchoring at plasma membrane (GO:0007016)2.83156676
127skin morphogenesis (GO:0043589)2.82888441
128epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.82695387
129water-soluble vitamin biosynthetic process (GO:0042364)2.82366186
130retinal rod cell development (GO:0046548)2.79965755
131glutathione derivative metabolic process (GO:1901685)2.77940673
132glutathione derivative biosynthetic process (GO:1901687)2.77940673
133iron ion import (GO:0097286)2.77890219
134microtubule polymerization or depolymerization (GO:0031109)2.76684457
135regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.76642575
136asymmetric protein localization (GO:0008105)2.76379422
137negative regulation of inclusion body assembly (GO:0090084)2.75317963
138toxin metabolic process (GO:0009404)2.74731615
139carnitine metabolic process (GO:0009437)2.71384648
140dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.71176327
141negative regulation of toll-like receptor signaling pathway (GO:0034122)2.69450984
142polyol transport (GO:0015791)2.68783654
143skeletal muscle adaptation (GO:0043501)2.67477516
144valine metabolic process (GO:0006573)2.66492704
145fibril organization (GO:0097435)2.66212806
146superoxide anion generation (GO:0042554)2.65721112
147fatty acid transmembrane transport (GO:1902001)2.65138885
148acrosome reaction (GO:0007340)2.65024565
149regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.64976778
150pentose metabolic process (GO:0019321)2.62743350
151embryonic camera-type eye development (GO:0031076)2.60178263
152positive regulation of cholesterol transport (GO:0032376)2.59086603
153positive regulation of sterol transport (GO:0032373)2.59086603
154muscle atrophy (GO:0014889)2.57673866
155planar cell polarity pathway involved in neural tube closure (GO:0090179)2.57504415
156hormone catabolic process (GO:0042447)2.57135740
157* protein O-linked glycosylation (GO:0006493)2.56491945
158interferon-gamma secretion (GO:0072643)2.55997743
159single fertilization (GO:0007338)2.54451636
160regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.52644154
161vitamin transmembrane transport (GO:0035461)2.52306917
162UDP-N-acetylglucosamine metabolic process (GO:0006047)2.52000715
163lung lobe morphogenesis (GO:0060463)2.51926559
164regulation of apoptotic cell clearance (GO:2000425)2.50286517
165plasma membrane repair (GO:0001778)2.49507980
166regulation of potassium ion transmembrane transporter activity (GO:1901016)2.48810751
167regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.47247374
168carnitine transmembrane transport (GO:1902603)2.46057927
169microtubule-based process (GO:0007017)2.41235954
170kidney mesenchyme development (GO:0072074)2.40943579
171photoreceptor cell maintenance (GO:0045494)2.40149858
172regulation of tolerance induction (GO:0002643)2.39913693
173import into cell (GO:0098657)2.37806213
174embryonic body morphogenesis (GO:0010172)2.36633734
175sphingomyelin metabolic process (GO:0006684)2.36147174
176quaternary ammonium group transport (GO:0015697)2.33983328
177motile cilium assembly (GO:0044458)12.4521976
178ethanol oxidation (GO:0006069)12.2982444
179primary alcohol catabolic process (GO:0034310)10.1148634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.71680689
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.68838904
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.50507454
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.93847277
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.81763965
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.72029987
7PCGF2_27294783_Chip-Seq_NPCs_Mouse2.50897490
8FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.34039593
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.28732207
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.18830181
11RUNX1_27514584_Chip-Seq_MCF-7_Human2.08309892
12AHR_22903824_ChIP-Seq_MCF-7_Human2.01183276
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.94348439
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92538308
15SUZ12_27294783_Chip-Seq_NPCs_Mouse1.92170577
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90138393
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88496209
18KLF5_25053715_ChIP-Seq_YYC3_Human1.88319191
19PPAR_26484153_Chip-Seq_NCI-H1993_Human1.85019640
20CTNNB1_20460455_ChIP-Seq_HCT116_Human1.84336236
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84012917
22NFE2_27457419_Chip-Seq_LIVER_Mouse1.81857765
23TCF4_18268006_ChIP-ChIP_LS174T_Human1.78715247
24P63_26484246_Chip-Seq_KERATINOCYTES_Human1.78578340
25LXR_22158963_ChIP-Seq_LIVER_Mouse1.74376243
26KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.69624413
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65279165
28SOX2_20726797_ChIP-Seq_SW620_Human1.64527134
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.63357119
30TP63_23658742_ChIP-Seq_EP156T_Human1.62881138
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62502045
32SMC4_20622854_ChIP-Seq_HELA_Human1.62386479
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60824155
34SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.60172635
35SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.60172635
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.60043629
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.59692895
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.56963945
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55372753
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53498982
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.51730111
42FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.49791203
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49614344
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49265836
45EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.48002423
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47656374
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46744077
48GATA4_25053715_ChIP-Seq_YYC3_Human1.46404117
49RACK7_27058665_Chip-Seq_MCF-7_Human1.45640032
50GATA3_24758297_ChIP-Seq_MCF-7_Human1.44920053
51TP63_22573176_ChIP-Seq_HFKS_Human1.43999362
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.42172716
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.41948623
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.40440154
55OCT4_18555785_Chip-Seq_ESCs_Mouse1.40279520
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.38551439
57TP53_16413492_ChIP-PET_HCT116_Human1.36510484
58AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.35999148
59SUZ12_18555785_Chip-Seq_ESCs_Mouse1.35841327
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.35074750
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.33556788
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32973948
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31901519
64ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.29328856
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29104313
66SOX2_18555785_Chip-Seq_ESCs_Mouse1.28548893
67P53_22387025_ChIP-Seq_ESCs_Mouse1.28489495
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27719135
69TP53_18474530_ChIP-ChIP_U2OS_Human1.26780609
70FOXA2_19822575_ChIP-Seq_HepG2_Human1.26504594
71P300_18555785_Chip-Seq_ESCs_Mouse1.26228230
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25939155
73CTCF_18555785_Chip-Seq_ESCs_Mouse1.24120416
74RXR_22158963_ChIP-Seq_LIVER_Mouse1.23692595
75ESRRB_18555785_Chip-Seq_ESCs_Mouse1.22932095
76* DROSHA_22980978_ChIP-Seq_HELA_Human1.22869105
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.22768458
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.22497767
79AR_21572438_ChIP-Seq_LNCaP_Human1.21532691
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21449065
81NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21449065
82GATA1_19941826_ChIP-Seq_K562_Human1.21100253
83PU1_27457419_Chip-Seq_LIVER_Mouse1.19617354
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18919098
85NMYC_18555785_Chip-Seq_ESCs_Mouse1.18864924
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18797909
87SMAD3_21741376_ChIP-Seq_HESCs_Human1.18216320
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17919137
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17290482
90FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16542554
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16334733
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15979684
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15338944
94KLF4_18555785_Chip-Seq_ESCs_Mouse1.15159633
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15047842
96FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15040590
97* GBX2_23144817_ChIP-Seq_PC3_Human1.13976248
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.13631932
99GATA6_25053715_ChIP-Seq_YYC3_Human1.13484685
100SMAD1_18555785_Chip-Seq_ESCs_Mouse1.12495389
101TAL1_26923725_Chip-Seq_HPCs_Mouse1.12458808
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12040935
103OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11936137
104STAT3_18555785_Chip-Seq_ESCs_Mouse1.11666525
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10406720
106SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10189898
107FOXA1_25552417_ChIP-Seq_VCAP_Human1.09806102
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09619934
109CDX2_20551321_ChIP-Seq_CACO-2_Human1.08354174
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07480037
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07337238
112KDM2B_26808549_Chip-Seq_REH_Human1.06571699
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06146234
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05703370
115SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04713508
116RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04480044
117RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04173801
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03671666
119ZFX_18555785_Chip-Seq_ESCs_Mouse1.03092718
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01803901
121GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00787567
122CREB1_26743006_Chip-Seq_LNCaP_Human1.00728561
123SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00303298
124PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99241995
125SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99012785
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98884879
127SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97794667
128TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97602299
129P68_20966046_ChIP-Seq_HELA_Human0.97372698
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97274375
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96771156
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96771156
133GATA2_19941826_ChIP-Seq_K562_Human0.96707006
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96622452
135EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96433070
136P300_19829295_ChIP-Seq_ESCs_Human0.95509014
137CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94570589
138MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94322751
139EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94315141
140EZH2_27294783_Chip-Seq_ESCs_Mouse0.94282828
141VDR_24787735_ChIP-Seq_THP-1_Human0.93921349
142ZNF263_19887448_ChIP-Seq_K562_Human0.93791252
143* CTCF_27219007_Chip-Seq_Bcells_Human0.93542683
144NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92893743
145TBX20_22328084_ChIP-Seq_HEART_Mouse0.92587030
146TBX20_22080862_ChIP-Seq_HEART_Mouse0.92587030
147SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92066097
148SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91464038
149CJUN_26792858_Chip-Seq_BT549_Human0.90875764
150BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90871437
151PPARA_22158963_ChIP-Seq_LIVER_Mouse0.90713908
152TP53_23651856_ChIP-Seq_MEFs_Mouse0.86571586
153RXR_22108803_ChIP-Seq_LS180_Human0.84546707
154* LXR_22292898_ChIP-Seq_THP-1_Human0.83665472
155SMRT_27268052_Chip-Seq_Bcells_Human0.83486599
156* SMAD4_21799915_ChIP-Seq_A2780_Human0.83044181
157WT1_25993318_ChIP-Seq_PODOCYTE_Human0.81965198
158ERG_21242973_ChIP-ChIP_JURKAT_Human0.81644345
159RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81519382
160KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81200236
161ETV1_20927104_ChIP-Seq_GIST48_Human0.81065428
162SMAD4_21741376_ChIP-Seq_HESCs_Human0.80441026
163PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.76249930
164VDR_22108803_ChIP-Seq_LS180_Human0.74768929
165MYC_27129775_Chip-Seq_CORNEA_Mouse0.74064779
166FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.73511304
167PHF8_20622854_ChIP-Seq_HELA_Human0.72968052
168CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72916443

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.77903896
2MP0004043_abnormal_pH_regulation5.44240540
3MP0000383_abnormal_hair_follicle3.95927640
4MP0010368_abnormal_lymphatic_system3.92638830
5MP0010678_abnormal_skin_adnexa3.38191336
6MP0008789_abnormal_olfactory_epithelium3.35908615
7MP0005394_taste/olfaction_phenotype3.23950672
8MP0005499_abnormal_olfactory_system3.23950672
9MP0010234_abnormal_vibrissa_follicle3.20339693
10MP0002132_abnormal_respiratory_system3.13196797
11MP0004019_abnormal_vitamin_homeostasis3.09270910
12MP0005670_abnormal_white_adipose3.04964265
13MP0002282_abnormal_trachea_morphology2.97658569
14MP0005410_abnormal_fertilization2.93075774
15MP0005365_abnormal_bile_salt2.92271732
16MP0010030_abnormal_orbit_morphology2.90553150
17MP0005409_darkened_coat_color2.88507644
18MP0003186_abnormal_redox_activity2.80165551
19MP0003453_abnormal_keratinocyte_physiol2.53174453
20MP0001984_abnormal_olfaction2.46958936
21MP0005248_abnormal_Harderian_gland2.34814157
22MP0001346_abnormal_lacrimal_gland2.21395014
23MP0003183_abnormal_peptide_metabolism2.17259115
24MP0008438_abnormal_cutaneous_collagen2.15691938
25MP0005171_absent_coat_pigmentation2.09567464
26MP0010352_gastrointestinal_tract_polyps2.06867614
27MP0002277_abnormal_respiratory_mucosa1.97496102
28MP0000566_synostosis1.95945593
29MP0004185_abnormal_adipocyte_glucose1.94507412
30MP0005023_abnormal_wound_healing1.90540870
31MP0005666_abnormal_adipose_tissue1.90533312
32MP0010329_abnormal_lipoprotein_level1.85476668
33MP0005076_abnormal_cell_differentiation1.85000181
34MP0002837_dystrophic_cardiac_calcinosis1.82551186
35MP0004133_heterotaxia1.81672307
36MP0004264_abnormal_extraembryonic_tissu1.76328951
37MP0003566_abnormal_cell_adhesion1.73250213
38MP0005408_hypopigmentation1.71373810
39MP0002160_abnormal_reproductive_system1.66260750
40MP0003950_abnormal_plasma_membrane1.62314126
41MP0005165_increased_susceptibility_to1.48627386
42MP0003136_yellow_coat_color1.48388967
43MP0003828_pulmonary_edema1.48176727
44MP0010771_integument_phenotype1.47711094
45MP0004130_abnormal_muscle_cell1.47620403
46MP0005503_abnormal_tendon_morphology1.43186630
47MP0001216_abnormal_epidermal_layer1.41616242
48MP0000678_abnormal_parathyroid_gland1.38602019
49MP0000467_abnormal_esophagus_morphology1.36643975
50MP0002295_abnormal_pulmonary_circulatio1.36273000
51MP0001756_abnormal_urination1.33915687
52MP0002876_abnormal_thyroid_physiology1.31743822
53MP0003329_amyloid_beta_deposits1.29698317
54MP0000003_abnormal_adipose_tissue1.29425462
55MP0005275_abnormal_skin_tensile1.29260151
56MP0003656_abnormal_erythrocyte_physiolo1.28757296
57MP0005085_abnormal_gallbladder_physiolo1.27349373
58MP0009780_abnormal_chondrocyte_physiolo1.25784358
59MP0005395_other_phenotype1.23995717
60MP0003724_increased_susceptibility_to1.23965251
61MP0005501_abnormal_skin_physiology1.23066529
62MP0002909_abnormal_adrenal_gland1.22466692
63MP0004272_abnormal_basement_membrane1.20274100
64MP0004883_abnormal_blood_vessel1.20072792
65MP0002139_abnormal_hepatobiliary_system1.16783196
66MP0003705_abnormal_hypodermis_morpholog1.10780792
67MP0001958_emphysema1.09687492
68MP0001765_abnormal_ion_homeostasis1.09345029
69MP0003878_abnormal_ear_physiology1.08560542
70MP0005377_hearing/vestibular/ear_phenot1.08560542
71MP0001879_abnormal_lymphatic_vessel1.08456574
72MP0002233_abnormal_nose_morphology1.06033099
73MP0002098_abnormal_vibrissa_morphology1.06003000
74MP0008995_early_reproductive_senescence1.04655342
75MP0005375_adipose_tissue_phenotype1.04343173
76MP0003091_abnormal_cell_migration1.04336408
77MP0002249_abnormal_larynx_morphology1.01852780
78MP0005164_abnormal_response_to1.00718245
79MP0008004_abnormal_stomach_pH1.00585406
80MP0002133_abnormal_respiratory_system0.99995816
81MP0005388_respiratory_system_phenotype0.99995816
82MP0003115_abnormal_respiratory_system0.99295493
83MP0003279_aneurysm0.98968381
84MP0006054_spinal_hemorrhage0.98952135
85MP0002653_abnormal_ependyma_morphology0.98001940
86MP0000613_abnormal_salivary_gland0.97362396
87MP0005647_abnormal_sex_gland0.97103579
88MP0010630_abnormal_cardiac_muscle0.96653858
89MP0002108_abnormal_muscle_morphology0.96137051
90MP0009643_abnormal_urine_homeostasis0.95470755
91MP0003045_fibrosis0.92912698
92MP0002102_abnormal_ear_morphology0.92862025
93MP0002118_abnormal_lipid_homeostasis0.91835222
94MP0001502_abnormal_circadian_rhythm0.91401855
95MP0001881_abnormal_mammary_gland0.90741348
96MP0000377_abnormal_hair_follicle0.90023817
97MP0000579_abnormal_nail_morphology0.89258183
98MP0005319_abnormal_enzyme/_coenzyme0.88293717
99MP0001177_atelectasis0.88031436
100MP0005636_abnormal_mineral_homeostasis0.87602538
101MP0002896_abnormal_bone_mineralization0.87532462
102MP0002254_reproductive_system_inflammat0.86213723
103MP0009764_decreased_sensitivity_to0.85401923
104MP0001188_hyperpigmentation0.82302057
105MP0010155_abnormal_intestine_physiology0.81789776
106MP0003698_abnormal_male_reproductive0.80785786
107MP0002971_abnormal_brown_adipose0.79506308
108MP0000249_abnormal_blood_vessel0.78346204
109MP0005389_reproductive_system_phenotype0.75689609
110MP0002136_abnormal_kidney_physiology0.74731987
111MP0005623_abnormal_meninges_morphology0.74687043
112MP0002060_abnormal_skin_morphology0.73742889
113MP0005257_abnormal_intraocular_pressure0.73311974
114MP0005083_abnormal_biliary_tract0.72117532
115MP0005595_abnormal_vascular_smooth0.70394910
116MP0009053_abnormal_anal_canal0.69105725
117MP0000609_abnormal_liver_physiology0.69088482
118MP0002928_abnormal_bile_duct0.68984841
119MP0002128_abnormal_blood_circulation0.68716523
120MP0004484_altered_response_of0.68303294
121MP0000681_abnormal_thyroid_gland0.67855176
122MP0001915_intracranial_hemorrhage0.67343052
123MP0000762_abnormal_tongue_morphology0.67004639
124MP0003690_abnormal_glial_cell0.66642148
125MP0002166_altered_tumor_susceptibility0.65556751
126MP0009115_abnormal_fat_cell0.65117283
127MP0001191_abnormal_skin_condition0.63240726
128MP0004381_abnormal_hair_follicle0.63025428
129MP0000733_abnormal_muscle_development0.62963281
130MP0000465_gastrointestinal_hemorrhage0.62822809
131MP0001929_abnormal_gametogenesis0.62692190
132MP0009697_abnormal_copulation0.62589589
133MP0002332_abnormal_exercise_endurance0.62431410
134MP0004947_skin_inflammation0.62287642
135MP0005334_abnormal_fat_pad0.62131108
136MP0001663_abnormal_digestive_system0.61682741
137MP0000013_abnormal_adipose_tissue0.60967276
138MP0000427_abnormal_hair_cycle0.59699107
139MP0005360_urolithiasis0.59253448
140MP0002116_abnormal_craniofacial_bone0.58929503
141MP0001299_abnormal_eye_distance/0.57573684
142MP0010386_abnormal_urinary_bladder0.56948932
143MP0001849_ear_inflammation0.56837957
144MP0003941_abnormal_skin_development0.56661738
145MP0005535_abnormal_body_temperature0.56151855
146MP0004782_abnormal_surfactant_physiolog0.55096523
147MP0002796_impaired_skin_barrier0.55090416
148MP0002168_other_aberrant_phenotype0.54839131
149MP0000627_abnormal_mammary_gland0.53612912
150MP0000639_abnormal_adrenal_gland0.52257415
151MP0003942_abnormal_urinary_system0.51182619
152MP0001270_distended_abdomen0.49398596
153MP0005174_abnormal_tail_pigmentation0.49116846

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)9.40802874
2Increased circulating renin level (HP:0000848)7.40072231
3Hypokalemic alkalosis (HP:0001949)6.60985570
4Tetany (HP:0001281)6.23075985
5Large eyes (HP:0001090)6.07593346
6Metabolic alkalosis (HP:0200114)5.96609137
7Hyperaldosteronism (HP:0000859)5.73655921
8Renal salt wasting (HP:0000127)5.22637106
9Abnormality of chloride homeostasis (HP:0011422)5.21058628
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.15198777
11Hypomagnesemia (HP:0002917)5.10769897
12Abnormal drinking behavior (HP:0030082)4.89097792
13Polydipsia (HP:0001959)4.89097792
14Abnormality of renin-angiotensin system (HP:0000847)4.80417703
15Abnormal ciliary motility (HP:0012262)4.20817570
16Abnormal respiratory motile cilium physiology (HP:0012261)4.19679411
17Abnormality of fatty-acid metabolism (HP:0004359)4.13167175
18Dynein arm defect of respiratory motile cilia (HP:0012255)4.02336496
19Absent/shortened dynein arms (HP:0200106)4.02336496
20Abnormality of magnesium homeostasis (HP:0004921)3.98022909
21Male infertility (HP:0003251)3.88744761
22Right ventricular cardiomyopathy (HP:0011663)3.86974027
23Hypercalciuria (HP:0002150)3.68956785
24Chronic sinusitis (HP:0011109)3.59083415
25Recurrent otitis media (HP:0000403)3.56348212
26Impaired platelet aggregation (HP:0003540)3.46756991
27Abnormal platelet function (HP:0011869)3.46756991
28Alkalosis (HP:0001948)3.34490746
29Chronic bronchitis (HP:0004469)3.30576763
30Occipital encephalocele (HP:0002085)3.26347791
31Osteomalacia (HP:0002749)3.17820513
32Hypokalemia (HP:0002900)3.14716039
33Tubulointerstitial nephritis (HP:0001970)3.10739292
34Renal cortical cysts (HP:0000803)3.07632282
35Abnormal respiratory epithelium morphology (HP:0012253)3.03863163
36Abnormal respiratory motile cilium morphology (HP:0005938)3.03863163
37Abnormality of renal excretion (HP:0011036)3.00250974
38Abnormality of Sharpey fibers (HP:0100685)2.99478287
39Polyuria (HP:0000103)2.99255590
40Chondrocalcinosis (HP:0000934)2.94703608
41Abnormal urine output (HP:0012590)2.87381055
42Abnormality of potassium homeostasis (HP:0011042)2.84201953
43Pancreatic fibrosis (HP:0100732)2.79872294
44Chronic hepatic failure (HP:0100626)2.79723490
45True hermaphroditism (HP:0010459)2.77058536
46Syncope (HP:0001279)2.66063806
47Adrenal overactivity (HP:0002717)2.65981046
48Atelectasis (HP:0100750)2.63060105
49Oligomenorrhea (HP:0000876)2.50517632
50Chronic otitis media (HP:0000389)2.50437277
51Hyperkalemia (HP:0002153)2.49634853
52Lip pit (HP:0100267)2.42711210
53Cystic liver disease (HP:0006706)2.41209136
54Rhinitis (HP:0012384)2.40924574
55Esophageal varix (HP:0002040)2.40270897
56Nephronophthisis (HP:0000090)2.35750293
57Abnormality of the renal cortex (HP:0011035)2.33728232
58Decreased circulating renin level (HP:0003351)2.30207425
59Bronchiectasis (HP:0002110)2.29567604
60Renal tubular acidosis (HP:0001947)2.26538911
61Infertility (HP:0000789)2.26019155
62Abnormal hemoglobin (HP:0011902)2.24171709
63Nephrocalcinosis (HP:0000121)2.21255668
64Tubular atrophy (HP:0000092)2.17681385
65Bell-shaped thorax (HP:0001591)2.17600064
66Molar tooth sign on MRI (HP:0002419)2.17252260
67Abnormality of midbrain morphology (HP:0002418)2.17252260
68Recurrent bronchitis (HP:0002837)2.17243823
69Hypotension (HP:0002615)2.14983616
70Pancreatic cysts (HP:0001737)2.13527731
71Tubulointerstitial abnormality (HP:0001969)2.11896373
72Palpitations (HP:0001962)2.05523842
73Muscle fiber splitting (HP:0003555)2.02938085
74Postaxial foot polydactyly (HP:0001830)2.02496024
75Hyperglycinuria (HP:0003108)2.01993213
76Onycholysis (HP:0001806)1.98099926
77Flat acetabular roof (HP:0003180)1.95906284
78Recurrent sinusitis (HP:0011108)1.95464107
79Popliteal pterygium (HP:0009756)1.95331298
80Ulnar bowing (HP:0003031)1.94020744
81Generalized muscle weakness (HP:0003324)1.93873938
82Pulmonary artery stenosis (HP:0004415)1.88987824
83Congenital hepatic fibrosis (HP:0002612)1.87683382
84Elfin facies (HP:0004428)1.86760603
85Azoospermia (HP:0000027)1.86301875
86Ventricular tachycardia (HP:0004756)1.85347878
87Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.82179407
88Nasal polyposis (HP:0100582)1.81289146
89Dehydration (HP:0001944)1.80776800
90Distal lower limb muscle weakness (HP:0009053)1.80460640
91Bronchitis (HP:0012387)1.79719200
92Reduced subcutaneous adipose tissue (HP:0003758)1.77248354
93Abnormality of dentin (HP:0010299)1.75844486
94Tubulointerstitial fibrosis (HP:0005576)1.75485063
95Renal tubular dysfunction (HP:0000124)1.75449690
96Lipoatrophy (HP:0100578)1.74827443
97Personality changes (HP:0000751)1.74582246
98Abnormality of the renal medulla (HP:0100957)1.74015161
99Increased connective tissue (HP:0009025)1.73930743
100Fragile skin (HP:0001030)1.73490434
101Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.71227209
102Bilateral sensorineural hearing impairment (HP:0008619)1.69314724
103Median cleft lip (HP:0000161)1.63914810
104Abnormality of the frontal sinuses (HP:0002687)1.61188588
105Long foot (HP:0001833)1.61064954
106Short thorax (HP:0010306)1.59780793
107Abnormality of the nasal mucosa (HP:0000433)1.59517505
108Pigmentary retinal degeneration (HP:0001146)1.59245107
109Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.58362740
110Degeneration of the lateral corticospinal tracts (HP:0002314)1.58362740
111Prenatal maternal abnormality (HP:0002686)1.57977018
112Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.57056468
113Acanthosis nigricans (HP:0000956)1.57047831
114Abnormality of the distal phalanges of the toes (HP:0010182)1.56948354
115Short nail (HP:0001799)1.56161748
116Mesomelia (HP:0003027)1.56139111
117Aplasia/Hypoplasia of the tongue (HP:0010295)1.54646721
118Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.54557281
119Ventricular arrhythmia (HP:0004308)1.53914230
120Hypoalphalipoproteinemia (HP:0003233)1.52775915
121Lower limb amyotrophy (HP:0007210)1.52464022
122Abnormal spermatogenesis (HP:0008669)1.50264989
123Glucose intolerance (HP:0000833)1.50050474
124Facial cleft (HP:0002006)1.48651726
125Renovascular hypertension (HP:0100817)1.48192382
126Anencephaly (HP:0002323)1.47279877
127Absent frontal sinuses (HP:0002688)1.46887720
128Stage 5 chronic kidney disease (HP:0003774)1.45972850
129Absent rod-and cone-mediated responses on ERG (HP:0007688)1.45952974
130Cone-rod dystrophy (HP:0000548)1.45380702
131Male pseudohermaphroditism (HP:0000037)1.45132508
132Furrowed tongue (HP:0000221)1.44466305
133Abnormality of the nasal septum (HP:0000419)1.43457234
134Spinal cord compression (HP:0002176)1.40396788
135Milia (HP:0001056)1.38491176
136Malnutrition (HP:0004395)1.37926433
137Cervical subluxation (HP:0003308)1.37726190
138Supraventricular tachycardia (HP:0004755)1.37444552
139Nephropathy (HP:0000112)1.36813884
140Abnormality of the labia majora (HP:0012881)1.36570573
141Hypoplastic labia majora (HP:0000059)1.35635140
142Abnormality of the dental root (HP:0006486)1.28239237
143Taurodontia (HP:0000679)1.28239237
144Abnormality of permanent molar morphology (HP:0011071)1.28239237
145Hypoplasia of the iris (HP:0007676)1.28170938
146Abnormality of the epiphyses of the hand (HP:0005924)1.26048642
147Obstructive sleep apnea (HP:0002870)1.25992800
148Down-sloping shoulders (HP:0200021)1.24459935
149Aplasia/Hypoplasia of the spleen (HP:0010451)1.22215485
150Abnormality of molar (HP:0011077)1.21682084
151Abnormality of molar morphology (HP:0011070)1.21682084
152Abnormal vertebral ossification (HP:0100569)1.20419664
153Abnormality of the dental pulp (HP:0006479)1.20115539
154Severe short stature (HP:0003510)1.20087751
155Epiphyseal dysplasia (HP:0002656)1.19934636
156Asplenia (HP:0001746)1.19866370
157Medial flaring of the eyebrow (HP:0010747)1.19283058
158Cardiovascular calcification (HP:0011915)1.18500579
159Decreased central vision (HP:0007663)1.17180658
160Proximal amyotrophy (HP:0007126)1.16551161
161Oculomotor apraxia (HP:0000657)1.16142999
162Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.16112078
163Neoplasm of the heart (HP:0100544)1.15848243
164Hyponatremia (HP:0002902)1.15312977
165Hand muscle atrophy (HP:0009130)1.14000162
166Striae distensae (HP:0001065)1.13989723

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SGK24.02105438
2PRKD33.85609583
3EPHA23.35737324
4PDK23.32680511
5SGK4943.31803465
6SGK2233.31803465
7SGK33.27869695
8MST43.16978503
9SIK13.14429442
10INSRR2.80655599
11PDK42.70012166
12PDK32.70012166
13CDK122.44630536
14LATS12.11191628
15STK392.04874018
16MET2.03086564
17STK38L1.99326785
18STK241.93675706
19EEF2K1.79049815
20WNK41.69096652
21ERN11.67518491
22ERBB31.66102616
23RPS6KB21.60226178
24PINK11.58514769
25DAPK21.56490260
26EPHB21.54973476
27CAMK1D1.50932348
28MAPKAPK51.49149148
29SIK31.48898623
30MAP3K21.36522188
31BCR1.34549235
32ZAK1.33982544
33STK101.33798752
34LMTK21.32207685
35CSK1.31825655
36MAPKAPK31.30367216
37STK381.24001908
38MST1R1.21234287
39FER1.12626150
40SMG11.11989713
41CAMK1G1.11509014
42ICK1.08485871
43MAP3K61.08467444
44TRIB31.07586852
45SIK20.98160991
46TRPM70.95985191
47MAPK150.89783568
48PDGFRB0.89654018
49SGK10.87087322
50EPHB10.86389194
51NME10.86180279
52PAK30.86054820
53DMPK0.84982977
54CDC42BPA0.82985512
55TLK10.82468767
56TYRO30.80851083
57RIPK10.80624703
58LATS20.77252000
59FRK0.75604189
60PRKD20.74919941
61ERBB20.73431414
62BRSK20.71665690
63MAP3K30.70799214
64TTN0.69530077
65MTOR0.69421894
66PRKAA20.69227459
67MARK20.69043316
68CAMK10.68562316
69TTK0.67762352
70NLK0.67032207
71RPS6KA20.66922430
72PIK3CA0.65519472
73MAP2K10.64882947
74LRRK20.64702815
75GRK10.63842206
76PTK20.61521127
77MAP3K70.60388687
78PRKCE0.58053226
79PRKCI0.58018230
80CDK60.57820142
81EIF2AK20.57682431
82MELK0.57390086
83WNK10.56771709
84PHKG10.56060497
85PHKG20.56060497
86MAP2K60.55789624
87PKN20.54638160
88TGFBR20.54524506
89EPHA30.53616060
90BCKDK0.50756168
91PRKD10.47263979
92TAOK10.47132029
93ADRBK20.46948234
94BMPR20.46876948
95NEK90.46230558
96BLK0.45702526
97TBK10.44613284
98JAK10.42713186
99AKT20.42617379
100RET0.42268630
101BMX0.41691569
102PTK2B0.41462089
103EPHA40.41118707
104NEK60.41070716
105ACVR1B0.40840187
106TESK10.40516747
107SRC0.39620305
108PRKCD0.39254096
109PRKCH0.38352933
110INSR0.37543194
111MARK30.37109970
112PNCK0.37074418
113MAPK130.36951442
114AKT30.36269103
115HIPK20.35594218
116PBK0.35584151
117PRKG20.35208156
118CAMK2D0.34160283
119ADRBK10.33800242
120ROCK20.32780002
121CHUK0.32491020
122PDPK10.31236675
123STK30.30924781
124DDR20.29219090
125OBSCN0.28542822
126TIE10.27768104
127ROCK10.27352368
128FYN0.27183305
129MAP2K20.27085597
130PRKCQ0.26698737
131MYLK0.26576014
132FGFR30.26405088
133STK40.26211066
134CAMK2G0.26035698
135ABL10.25839423
136PRKAA10.25667024
137TEC0.25264917
138MAPK110.23801524
139CAMKK10.23036200
140ZAP700.20311562
141MAP3K120.18843468
142BRD40.15887461
143RPS6KA60.15619287
144MAPK10.15517406
145EGFR0.15395189
146MUSK0.14393338
147IRAK10.13089462

Predicted pathways (KEGG)

RankGene SetZ-score
1Drug metabolism - cytochrome P450_Homo sapiens_hsa009825.42716023
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.64480085
3Pentose and glucuronate interconversions_Homo sapiens_hsa000404.28550896
4Chemical carcinogenesis_Homo sapiens_hsa052044.00226625
5Sulfur metabolism_Homo sapiens_hsa009203.38090212
6Fatty acid degradation_Homo sapiens_hsa000713.14009543
7Tyrosine metabolism_Homo sapiens_hsa003503.01555561
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.97320070
9Retinol metabolism_Homo sapiens_hsa008302.92271331
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.49573400
11Propanoate metabolism_Homo sapiens_hsa006402.07549907
12Sulfur relay system_Homo sapiens_hsa041222.07339089
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.99704400
14Sphingolipid metabolism_Homo sapiens_hsa006001.99190611
15beta-Alanine metabolism_Homo sapiens_hsa004101.95010069
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.85080978
17Fatty acid biosynthesis_Homo sapiens_hsa000611.62561491
18Glycerolipid metabolism_Homo sapiens_hsa005611.60483261
19Phenylalanine metabolism_Homo sapiens_hsa003601.58379226
20Histidine metabolism_Homo sapiens_hsa003401.49675394
21Hedgehog signaling pathway_Homo sapiens_hsa043401.44052586
22Other glycan degradation_Homo sapiens_hsa005111.42439291
23Gastric acid secretion_Homo sapiens_hsa049711.41921097
24Selenocompound metabolism_Homo sapiens_hsa004501.38764288
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34262406
26PPAR signaling pathway_Homo sapiens_hsa033201.31257483
27Glutathione metabolism_Homo sapiens_hsa004801.31210859
28Huntingtons disease_Homo sapiens_hsa050161.31153744
29Caffeine metabolism_Homo sapiens_hsa002321.28813623
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.27139226
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22085512
32Starch and sucrose metabolism_Homo sapiens_hsa005001.21411065
33Fatty acid metabolism_Homo sapiens_hsa012121.18285145
34Basal cell carcinoma_Homo sapiens_hsa052171.17442983
35Notch signaling pathway_Homo sapiens_hsa043301.08033805
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06362637
37Choline metabolism in cancer_Homo sapiens_hsa052311.04102461
38Pentose phosphate pathway_Homo sapiens_hsa000301.00409366
39Complement and coagulation cascades_Homo sapiens_hsa046100.99887922
40Pyruvate metabolism_Homo sapiens_hsa006200.99506634
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96377817
42Hepatitis C_Homo sapiens_hsa051600.95621770
43Collecting duct acid secretion_Homo sapiens_hsa049660.95321170
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92216205
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89361636
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88498278
47Hippo signaling pathway_Homo sapiens_hsa043900.87394566
48ABC transporters_Homo sapiens_hsa020100.87257374
49Butanoate metabolism_Homo sapiens_hsa006500.80899253
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79612819
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78419993
52ECM-receptor interaction_Homo sapiens_hsa045120.77769601
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75051627
54Fructose and mannose metabolism_Homo sapiens_hsa000510.73040747
55Proteoglycans in cancer_Homo sapiens_hsa052050.72923580
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71122406
57Peroxisome_Homo sapiens_hsa041460.67912245
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66544769
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.64239404
60Melanogenesis_Homo sapiens_hsa049160.62387226
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.62148100
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60568028
63Prostate cancer_Homo sapiens_hsa052150.60266381
64Arachidonic acid metabolism_Homo sapiens_hsa005900.60080288
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.59820097
66Tryptophan metabolism_Homo sapiens_hsa003800.56941199
67Thyroid cancer_Homo sapiens_hsa052160.56071306
68Adherens junction_Homo sapiens_hsa045200.54722916
69Glucagon signaling pathway_Homo sapiens_hsa049220.53960655
70Tight junction_Homo sapiens_hsa045300.52894426
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52643837
72Lysine degradation_Homo sapiens_hsa003100.50474492
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.50207726
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49894318
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.49735134
76mTOR signaling pathway_Homo sapiens_hsa041500.49369026
77Endocytosis_Homo sapiens_hsa041440.48560776
78Ovarian steroidogenesis_Homo sapiens_hsa049130.47822135
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47577739
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.47282475
81Pathways in cancer_Homo sapiens_hsa052000.46098592
82Bladder cancer_Homo sapiens_hsa052190.45989744
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45617660
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44797557
85Pancreatic cancer_Homo sapiens_hsa052120.43474591
86Inositol phosphate metabolism_Homo sapiens_hsa005620.43084387
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42804831
88Fat digestion and absorption_Homo sapiens_hsa049750.42460014
89Carbon metabolism_Homo sapiens_hsa012000.42411166
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42263781
91Endometrial cancer_Homo sapiens_hsa052130.39569211
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35547109
93cAMP signaling pathway_Homo sapiens_hsa040240.33938918
94Axon guidance_Homo sapiens_hsa043600.32775179
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32582652
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31977257
97TGF-beta signaling pathway_Homo sapiens_hsa043500.31889599
98Dorso-ventral axis formation_Homo sapiens_hsa043200.31707805
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31705332
100Dilated cardiomyopathy_Homo sapiens_hsa054140.31444362
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.30774947
102MicroRNAs in cancer_Homo sapiens_hsa052060.30513338
103Circadian rhythm_Homo sapiens_hsa047100.30047662
104Insulin resistance_Homo sapiens_hsa049310.28334991
105Cocaine addiction_Homo sapiens_hsa050300.28298040
106Wnt signaling pathway_Homo sapiens_hsa043100.27476131
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26470911
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.25989808
109Renal cell carcinoma_Homo sapiens_hsa052110.25910284
110Protein digestion and absorption_Homo sapiens_hsa049740.25784798
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.25771851
112Toxoplasmosis_Homo sapiens_hsa051450.25704680
113Salivary secretion_Homo sapiens_hsa049700.25619051
114AMPK signaling pathway_Homo sapiens_hsa041520.25430490
115Lysosome_Homo sapiens_hsa041420.25278476
116Arginine biosynthesis_Homo sapiens_hsa002200.25073944
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24799176
118Amoebiasis_Homo sapiens_hsa051460.24058560
119Vibrio cholerae infection_Homo sapiens_hsa051100.23764408
120Renin secretion_Homo sapiens_hsa049240.23611242
121TNF signaling pathway_Homo sapiens_hsa046680.23482605
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23017407
123Leishmaniasis_Homo sapiens_hsa051400.22079543
124Galactose metabolism_Homo sapiens_hsa000520.20783386
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20649628
126Hematopoietic cell lineage_Homo sapiens_hsa046400.20549184
127Linoleic acid metabolism_Homo sapiens_hsa005910.19153361
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.18590228
129Thyroid hormone synthesis_Homo sapiens_hsa049180.18560919
130Fatty acid elongation_Homo sapiens_hsa000620.18264504
131Bile secretion_Homo sapiens_hsa049760.17745894
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17495669
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16900098
134Metabolic pathways_Homo sapiens_hsa011000.16894055
135Rheumatoid arthritis_Homo sapiens_hsa053230.16621009
136Taste transduction_Homo sapiens_hsa047420.15354468
137Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15210287
138Vitamin digestion and absorption_Homo sapiens_hsa049770.14032274
139Focal adhesion_Homo sapiens_hsa045100.13978660
140Viral myocarditis_Homo sapiens_hsa054160.13949971
141Osteoclast differentiation_Homo sapiens_hsa043800.13174488
142Staphylococcus aureus infection_Homo sapiens_hsa051500.12985338
143Glycosaminoglycan degradation_Homo sapiens_hsa005310.12524692
144Small cell lung cancer_Homo sapiens_hsa052220.12429165
145Calcium signaling pathway_Homo sapiens_hsa040200.11134828
146Phagosome_Homo sapiens_hsa041450.10363811
147Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.10113729
148Malaria_Homo sapiens_hsa051440.09918897

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