MUC17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)8.96889471
2lipoprotein transport (GO:0042953)7.40543986
3regulation of guanylate cyclase activity (GO:0031282)7.33961148
4intestinal absorption (GO:0050892)6.89364693
5regulation of bile acid biosynthetic process (GO:0070857)6.84124116
6NADH metabolic process (GO:0006734)6.51859889
7epoxygenase P450 pathway (GO:0019373)6.37926332
8fat-soluble vitamin biosynthetic process (GO:0042362)6.15576240
9positive regulation of guanylate cyclase activity (GO:0031284)5.69541703
10regulation of cellular extravasation (GO:0002691)5.55022917
11regulation of systemic arterial blood pressure by hormone (GO:0001990)5.44658319
12regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.44658319
13endocrine process (GO:0050886)5.44658319
14hormone catabolic process (GO:0042447)5.31371786
15virion attachment to host cell (GO:0019062)5.13353773
16adhesion of symbiont to host cell (GO:0044650)5.13353773
17maintenance of gastrointestinal epithelium (GO:0030277)5.09666457
18cellular glucuronidation (GO:0052695)4.98896771
19fructose metabolic process (GO:0006000)4.98233153
20regulation of systemic arterial blood pressure (GO:0003073)4.92778232
21glucuronate metabolic process (GO:0019585)4.89153973
22uronic acid metabolic process (GO:0006063)4.89153973
23drug metabolic process (GO:0017144)4.68136191
24receptor guanylyl cyclase signaling pathway (GO:0007168)4.65458168
25peptide hormone processing (GO:0016486)4.60538939
26urea cycle (GO:0000050)4.58153189
27digestion (GO:0007586)4.51679781
28bile acid and bile salt transport (GO:0015721)4.48804260
29regulation of cGMP biosynthetic process (GO:0030826)4.43612743
30regulation of triglyceride catabolic process (GO:0010896)4.41531860
31antibacterial humoral response (GO:0019731)4.37578366
32adhesion of symbiont to host (GO:0044406)4.35457678
33diacylglycerol metabolic process (GO:0046339)4.35236218
34urea metabolic process (GO:0019627)4.34819444
35glycosphingolipid catabolic process (GO:0046479)4.26864466
36vitamin A metabolic process (GO:0006776)4.26702395
37glycolipid catabolic process (GO:0019377)4.24798877
38peptide catabolic process (GO:0043171)4.21951421
39antimicrobial humoral response (GO:0019730)4.20900578
40very-low-density lipoprotein particle assembly (GO:0034379)4.19688012
41flavonoid metabolic process (GO:0009812)4.13897685
42regulation of vitamin metabolic process (GO:0030656)4.11589449
43nitrogen cycle metabolic process (GO:0071941)3.97635241
44renal system process involved in regulation of blood volume (GO:0001977)3.95607683
45drinking behavior (GO:0042756)3.90787962
46plasma lipoprotein particle assembly (GO:0034377)3.76508312
47alkaloid metabolic process (GO:0009820)3.71992969
48lipoprotein metabolic process (GO:0042157)3.70887172
49epithelial structure maintenance (GO:0010669)3.70469481
50digestive system process (GO:0022600)3.68218185
51regulation of cGMP metabolic process (GO:0030823)3.67744933
52drug catabolic process (GO:0042737)3.63587179
53positive regulation of pseudopodium assembly (GO:0031274)3.61611108
54cellular response to nitric oxide (GO:0071732)3.55474848
55positive regulation of glycoprotein biosynthetic process (GO:0010560)3.55200352
56vitamin transmembrane transport (GO:0035461)3.54805918
57arginine metabolic process (GO:0006525)3.51499428
58fat-soluble vitamin metabolic process (GO:0006775)3.48526024
59antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.48043091
60protein-lipid complex assembly (GO:0065005)3.47684361
61midgut development (GO:0007494)3.47499839
62regulation of cholesterol homeostasis (GO:2000188)3.47039672
63ceramide catabolic process (GO:0046514)3.46688804
64homocysteine metabolic process (GO:0050667)3.44890574
65mRNA modification (GO:0016556)3.42010693
66glutamine family amino acid biosynthetic process (GO:0009084)3.41750988
67glycosylceramide metabolic process (GO:0006677)3.40229360
68exogenous drug catabolic process (GO:0042738)3.38207936
69bile acid metabolic process (GO:0008206)3.36197268
70vitamin transport (GO:0051180)3.34231654
71fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.31677865
72antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.31663201
73sulfate transmembrane transport (GO:1902358)3.31456954
74actin filament depolymerization (GO:0030042)3.28146599
75drug transport (GO:0015893)3.27172087
76positive regulation of cGMP biosynthetic process (GO:0030828)3.27003727
77regulation of pseudopodium assembly (GO:0031272)3.23271695
78sphingomyelin metabolic process (GO:0006684)3.22979421
79cGMP biosynthetic process (GO:0006182)3.20531689
80sphingolipid catabolic process (GO:0030149)3.19988998
81response to nitric oxide (GO:0071731)3.19681041
82positive regulation of glycoprotein metabolic process (GO:1903020)3.17988267
83cellular response to reactive nitrogen species (GO:1902170)3.17706606
84drug transmembrane transport (GO:0006855)3.17533923
85citrulline biosynthetic process (GO:0019240)3.16447194
86glycerol metabolic process (GO:0006071)3.15965215
87transcytosis (GO:0045056)3.15805002
88phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.15440893
89sexual reproduction (GO:0019953)3.14501767
90glomerulus development (GO:0032835)3.14329313
91nucleoside diphosphate biosynthetic process (GO:0009133)3.13632478
92antigen processing and presentation of endogenous antigen (GO:0019883)3.13445290
93cGMP-mediated signaling (GO:0019934)3.12114635
94auditory receptor cell differentiation (GO:0042491)3.07980883
95bundle of His cell to Purkinje myocyte communication (GO:0086069)3.06074724
96phospholipid efflux (GO:0033700)3.05370117
97membrane lipid catabolic process (GO:0046466)3.03540316
98vitamin biosynthetic process (GO:0009110)3.00268552
99negative regulation of steroid metabolic process (GO:0045939)2.99166349
100angiotensin maturation (GO:0002003)11.3957300

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human5.51473522
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.25628018
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.51918369
4GATA4_25053715_ChIP-Seq_YYC3_Human3.08361133
5SOX2_27498859_Chip-Seq_STOMACH_Mouse3.05505771
6HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.93238861
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.68428987
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.55797480
9GATA6_25053715_ChIP-Seq_YYC3_Human2.55434515
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.51216613
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.47948540
12SOX2_20726797_ChIP-Seq_SW620_Human2.35238833
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.35103032
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.30272625
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.29931176
16GATA1_22025678_ChIP-Seq_K562_Human2.25691168
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.15091919
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.10764741
19BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.09399249
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.06845102
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.94725557
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.91461878
23* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.89885231
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87353470
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.77308995
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.71553022
27TCF4_18268006_ChIP-ChIP_LS174T_Human1.68145142
28AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.68111408
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66370615
30NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.60521982
31PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.56152648
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.49846918
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.46765715
34CDX2_22108803_ChIP-Seq_LS180_Human1.45077953
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.38481162
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37266496
37FOXA1_25552417_ChIP-Seq_VCAP_Human1.32832011
38CLOCK_20551151_ChIP-Seq_293T_Human1.30141349
39HNF4A_19822575_ChIP-Seq_HepG2_Human1.29873040
40GATA2_19941826_ChIP-Seq_K562_Human1.28052267
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26270559
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25560422
43ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23990238
44* LXR_22292898_ChIP-Seq_THP-1_Human1.19457740
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17602250
46KLF5_25053715_ChIP-Seq_YYC3_Human1.17566938
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13967876
48FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11951090
49EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10577912
50BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08120742
51GATA1_19941826_ChIP-Seq_K562_Human1.08041405
52AR_21909140_ChIP-Seq_LNCAP_Human1.07855939
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.07621188
54RXR_22108803_ChIP-Seq_LS180_Human1.06155363
55* FOXA2_19822575_ChIP-Seq_HepG2_Human1.05162084
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97892123
57VDR_24787735_ChIP-Seq_THP-1_Human0.96198261
58P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95794582
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95540660
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95498520
61EGR1_19032775_ChIP-ChIP_M12_Human0.95163373
62RACK7_27058665_Chip-Seq_MCF-7_Human0.94982192
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94197093
64CEBPB_22108803_ChIP-Seq_LS180_Human0.94195505
65GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93322109
66JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92538055
67RUNX1_27514584_Chip-Seq_MCF-7_Human0.92314803
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91434561
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91424519
70FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90834126
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90822744
72DROSHA_22980978_ChIP-Seq_HELA_Human0.90818370
73NANOG_20526341_ChIP-Seq_ESCs_Human0.90442459
74ESR2_21235772_ChIP-Seq_MCF-7_Human0.90178868
75SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89742007
76TP63_23658742_ChIP-Seq_EP156T_Human0.88335705
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86704309
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85898964
79IRF8_27001747_Chip-Seq_BMDM_Mouse0.85756416
80BCOR_27268052_Chip-Seq_Bcells_Human0.83494154
81NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82842206
82GATA3_24758297_ChIP-Seq_MCF-7_Human0.82487366
83BCAT_22108803_ChIP-Seq_LS180_Human0.81885847
84FOXA1_21572438_ChIP-Seq_LNCaP_Human0.81805716
85SA1_27219007_Chip-Seq_Bcells_Human0.81503133
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81290294
87BCL6_27268052_Chip-Seq_Bcells_Human0.81054403
88TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.80227947
89CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.79907320
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79380474
91GATA2_21666600_ChIP-Seq_HMVEC_Human0.79077723
92TCF3_18692474_ChIP-Seq_MEFs_Mouse0.78301617
93SMAD_19615063_ChIP-ChIP_OVARY_Human0.76581521
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76252011
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74992040
96TET1_21451524_ChIP-Seq_MESCs_Mouse0.71680956
97STAT1_20625510_ChIP-Seq_HELA_Human0.70654275
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.70603785
99VDR_24763502_ChIP-Seq_THP-1_Human0.70468682
100KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70166945

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.82614628
2MP0001666_abnormal_nutrient_absorption4.82838027
3MP0005085_abnormal_gallbladder_physiolo4.81716493
4MP0003183_abnormal_peptide_metabolism4.68511384
5MP0004147_increased_porphyrin_level3.88358244
6MP0005365_abnormal_bile_salt3.73404489
7MP0004264_abnormal_extraembryonic_tissu3.57823943
8MP0002139_abnormal_hepatobiliary_system3.53534089
9MP0004019_abnormal_vitamin_homeostasis3.42390680
10MP0009379_abnormal_foot_pigmentation3.39783423
11MP0009840_abnormal_foam_cell3.01946277
12MP0010155_abnormal_intestine_physiology2.98099505
13MP0010234_abnormal_vibrissa_follicle2.89535885
14MP0003866_abnormal_defecation2.35668219
15MP0005409_darkened_coat_color2.12181533
16MP0001664_abnormal_digestion2.10737551
17MP0010329_abnormal_lipoprotein_level2.03706782
18MP0003868_abnormal_feces_composition1.85123933
19MP0005332_abnormal_amino_acid1.77061090
20MP0000490_abnormal_crypts_of1.74037722
21MP0009643_abnormal_urine_homeostasis1.72352875
22MP0003252_abnormal_bile_duct1.71147978
23MP0010352_gastrointestinal_tract_polyps1.65328450
24MP0005166_decreased_susceptibility_to1.58717968
25MP0000538_abnormal_urinary_bladder1.56524670
26MP0000477_abnormal_intestine_morphology1.54570439
27MP0001764_abnormal_homeostasis1.51274883
28MP0003806_abnormal_nucleotide_metabolis1.48188283
29MP0001873_stomach_inflammation1.41049749
30MP0001663_abnormal_digestive_system1.39354669
31MP0005670_abnormal_white_adipose1.39275428
32MP0001765_abnormal_ion_homeostasis1.39040585
33MP0000465_gastrointestinal_hemorrhage1.37335894
34MP0004858_abnormal_nervous_system1.34542093
35MP0002876_abnormal_thyroid_physiology1.33330023
36MP0001188_hyperpigmentation1.28934222
37MP0000678_abnormal_parathyroid_gland1.28502554
38MP0005636_abnormal_mineral_homeostasis1.27486386
39MP0001501_abnormal_sleep_pattern1.27022929
40MP0004782_abnormal_surfactant_physiolog1.21085978
41MP0002822_catalepsy1.16927216
42MP0002136_abnormal_kidney_physiology1.16920278
43MP0005381_digestive/alimentary_phenotyp1.14919636
44MP0004270_analgesia1.13405541
45MP0002118_abnormal_lipid_homeostasis1.11875574
46MP0003879_abnormal_hair_cell1.10873838
47MP0003718_maternal_effect1.09861987
48MP0004043_abnormal_pH_regulation1.09547275
49MP0000462_abnormal_digestive_system1.03625031
50MP0005448_abnormal_energy_balance1.01349518
51MP0000609_abnormal_liver_physiology0.95761533
52MP0005535_abnormal_body_temperature0.94786170
53MP0005584_abnormal_enzyme/coenzyme_acti0.92481612
54MP0001845_abnormal_inflammatory_respons0.92268041
55MP0002396_abnormal_hematopoietic_system0.89093878
56MP0003300_gastrointestinal_ulcer0.88124677
57MP0002971_abnormal_brown_adipose0.86136534
58MP0002098_abnormal_vibrissa_morphology0.83210544
59MP0000230_abnormal_systemic_arterial0.82853953
60MP0001756_abnormal_urination0.80975515
61MP0005319_abnormal_enzyme/_coenzyme0.77497130
62MP0009785_altered_susceptibility_to0.76719439
63MP0003724_increased_susceptibility_to0.75580485
64MP0009115_abnormal_fat_cell0.74700581
65MP0002796_impaired_skin_barrier0.74683485
66MP0008469_abnormal_protein_level0.74211740
67MP0005451_abnormal_body_composition0.74074818
68MP0002166_altered_tumor_susceptibility0.74032774
69MP0000537_abnormal_urethra_morphology0.74007577
70MP0001485_abnormal_pinna_reflex0.72528324
71MP0004947_skin_inflammation0.68251099
72MP0006082_CNS_inflammation0.67180176
73MP0009642_abnormal_blood_homeostasis0.65991143
74MP0001835_abnormal_antigen_presentation0.65280748
75MP0000604_amyloidosis0.63374927
76MP0003329_amyloid_beta_deposits0.63062611
77MP0005025_abnormal_response_to0.63050604
78MP0003303_peritoneal_inflammation0.62523456
79MP0008875_abnormal_xenobiotic_pharmacok0.60333470
80MP0000249_abnormal_blood_vessel0.59235808
81MP0009764_decreased_sensitivity_to0.58636578
82MP0008872_abnormal_physiological_respon0.57538582
83MP0002138_abnormal_hepatobiliary_system0.57291931
84MP0002896_abnormal_bone_mineralization0.56809407
85MP0005666_abnormal_adipose_tissue0.56781479
86MP0003191_abnormal_cellular_cholesterol0.56260638
87MP0001790_abnormal_immune_system0.56022179
88MP0005387_immune_system_phenotype0.56022179
89MP0005501_abnormal_skin_physiology0.55000415
90MP0006138_congestive_heart_failure0.50676387
91MP0001881_abnormal_mammary_gland0.50669504
92MP0009333_abnormal_splenocyte_physiolog0.50178974
93MP0005165_increased_susceptibility_to0.49851486
94MP0005174_abnormal_tail_pigmentation0.49344439
95MP0005310_abnormal_salivary_gland0.49180698
96MP0003436_decreased_susceptibility_to0.48651836
97MP0002006_tumorigenesis0.48169199
98MP0003953_abnormal_hormone_level0.46171118
99MP0005334_abnormal_fat_pad0.45289411
100MP0002078_abnormal_glucose_homeostasis0.43284257

Predicted human phenotypes

RankGene SetZ-score
1Hydroxyprolinuria (HP:0003080)7.36607947
2Abnormality of proline metabolism (HP:0010907)7.36607947
3Malnutrition (HP:0004395)7.12300164
4Hypobetalipoproteinemia (HP:0003563)5.89073978
5Chronic diarrhea (HP:0002028)5.73409712
6Ileus (HP:0002595)5.30385010
7Abnormality of the vitamin B12 metabolism (HP:0004341)5.29391254
8Acanthocytosis (HP:0001927)5.22558266
9Fat malabsorption (HP:0002630)4.99174934
10Abnormality of vitamin B metabolism (HP:0004340)4.93722160
11Widely patent fontanelles and sutures (HP:0004492)4.50090100
12Confusion (HP:0001289)4.17358174
13Pigmentary retinal degeneration (HP:0001146)4.11104293
14Abnormality of vitamin metabolism (HP:0100508)3.91231166
15Hyperglycinuria (HP:0003108)3.80970937
16Hyperactive renin-angiotensin system (HP:0000841)3.68852953
17Systemic lupus erythematosus (HP:0002725)3.62755764
18Thin bony cortex (HP:0002753)3.52005878
19Abnormality of urine glucose concentration (HP:0011016)3.49782544
20Glycosuria (HP:0003076)3.49782544
21Nausea (HP:0002018)3.35311921
22Wide cranial sutures (HP:0010537)3.33264421
23Abdominal distention (HP:0003270)3.27101241
24Nephrolithiasis (HP:0000787)3.26639979
25Decreased circulating renin level (HP:0003351)3.25118123
26Congenital sensorineural hearing impairment (HP:0008527)3.17259510
27Abnormality of glycine metabolism (HP:0010895)3.15267495
28Abnormality of serine family amino acid metabolism (HP:0010894)3.15267495
29Abnormality of monocarboxylic acid metabolism (HP:0010996)3.13539379
30Proximal tubulopathy (HP:0000114)3.10955340
31Metabolic alkalosis (HP:0200114)3.08185156
32Alkalosis (HP:0001948)3.04583253
33Steatorrhea (HP:0002570)2.94018253
34Right ventricular cardiomyopathy (HP:0011663)2.92576820
35Abnormality of small intestinal villus morphology (HP:0011472)2.86843611
36Villous atrophy (HP:0011473)2.86843611
37Potter facies (HP:0002009)2.86026951
38Facial shape deformation (HP:0011334)2.86026951
39Xanthomatosis (HP:0000991)2.85786677
40Eczematoid dermatitis (HP:0000976)2.85424545
41Hypolipoproteinemia (HP:0010981)2.85060446
42Abnormality of renin-angiotensin system (HP:0000847)2.75347847
43Hypophosphatemia (HP:0002148)2.73561520
44Posterior subcapsular cataract (HP:0007787)2.72586241
45Megaloblastic anemia (HP:0001889)2.68277400
46Increased purine levels (HP:0004368)2.67987783
47Hyperuricemia (HP:0002149)2.67987783
48Enlarged epiphyses (HP:0010580)2.65171524
49Hyperammonemia (HP:0001987)2.64965724
50Hyperparathyroidism (HP:0000843)2.64148165
51Focal segmental glomerulosclerosis (HP:0000097)2.59895029
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.49412010
53Abnormality of purine metabolism (HP:0004352)2.46604252
54Hemorrhage of the eye (HP:0011885)2.45877300
55Delayed epiphyseal ossification (HP:0002663)2.39501931
56Abnormal glucose tolerance (HP:0001952)2.35489251
57Abnormal urine phosphate concentration (HP:0012599)2.34367384
58Hypotension (HP:0002615)2.33773130
59Poikilocytosis (HP:0004447)2.26148671
60Abnormality of the costochondral junction (HP:0000919)2.26089768
61Abnormality of nucleobase metabolism (HP:0010932)2.22654544
62Conjugated hyperbilirubinemia (HP:0002908)2.19389683
63Flat acetabular roof (HP:0003180)2.18973966
64Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.17419733
65Hyperphosphaturia (HP:0003109)2.17224980
66Epidermoid cyst (HP:0200040)2.16637861
67Hyperphosphatemia (HP:0002905)2.14873971
68Cerebral palsy (HP:0100021)2.14277388
69Gingivitis (HP:0000230)2.12695631
70Protuberant abdomen (HP:0001538)2.09586461
71Metabolic acidosis (HP:0001942)2.08767071
72Gastrointestinal dysmotility (HP:0002579)2.05009947
73Intrahepatic cholestasis (HP:0001406)2.02398471
74Subcapsular cataract (HP:0000523)2.02048246
75Abnormality of glutamine family amino acid metabolism (HP:0010902)10.6003853
76Pancreatitis (HP:0001733)1.97778092
77Abnormal biliary tract morphology (HP:0012440)1.97284613
78Glomerulosclerosis (HP:0000096)1.92697561
79Renal tubular acidosis (HP:0001947)1.89757574
80Abnormality of magnesium homeostasis (HP:0004921)1.87817450
81Gout (HP:0001997)1.85808886
82Abnormality of sulfur amino acid metabolism (HP:0004339)1.84947818
83Dehydration (HP:0001944)1.84313355
84Irritability (HP:0000737)1.81447971
85Glomerulonephritis (HP:0000099)1.79912434
86Growth hormone excess (HP:0000845)1.77433095
87Multiple lipomas (HP:0001012)1.77006774
88Segmental peripheral demyelination/remyelination (HP:0003481)1.76534099
89Dicarboxylic aciduria (HP:0003215)1.76390373
90Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76390373
91Biliary tract neoplasm (HP:0100574)1.75323939
92Nephritis (HP:0000123)1.75221331
93Hyperaldosteronism (HP:0000859)1.74828722
94Metaphyseal irregularity (HP:0003025)1.71599079
95Symptomatic seizures (HP:0011145)1.71315301
96Abnormal tarsal ossification (HP:0008369)1.70490290
97Abnormality of pyrimidine metabolism (HP:0004353)1.70400635
98Abnormality of complement system (HP:0005339)1.68261741
99Peripheral demyelination (HP:0011096)1.67549489
100Abnormal enzyme/coenzyme activity (HP:0012379)1.66261049

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.90971225
2MST1R5.36821444
3ERN14.02767195
4RIPK13.68830722
5MAP3K103.51293310
6PRKG23.39045467
7STK393.05377294
8EPHA22.79272467
9OXSR12.37489014
10MET2.03474385
11FGFR41.84172258
12EPHA31.80691381
13TESK21.66601150
14MAP3K21.63039463
15TYK21.59016513
16EPHB21.57408196
17TNIK1.54415339
18MAP3K121.48200116
19PIK3CA1.46933014
20PTK61.45133677
21EPHB11.43380157
22LMTK21.35453839
23MST41.35079481
24PDK21.32504728
25DDR21.30756585
26STK241.18644137
27GRK61.17190271
28PRPF4B1.16315194
29FGFR31.13414280
30AKT31.13308403
31NLK1.05516017
32MATK1.04057775
33MAP4K11.03739595
34MYLK1.01780711
35MAP3K10.99159247
36RIPK40.96541913
37ERBB20.91434326
38CASK0.88336902
39MAP2K20.87331769
40EPHA40.86127099
41BMPR20.81269179
42CDC42BPA0.79949056
43PDPK10.77969972
44FER0.74133706
45IRAK10.73295360
46PRKAA20.72764060
47PIM10.70566962
48MAPK110.67081534
49TESK10.67036111
50MAP2K60.66686863
51PRKACG0.66417724
52JAK10.62555329
53TAOK10.60750208
54PDK10.59485070
55PRKCA0.54535060
56YES10.49308438
57DYRK1B0.49292673
58RET0.48539156
59PRKCZ0.48507007
60MAP3K110.45513325
61CAMK2D0.44818870
62SRC0.44445873
63FRK0.43906260
64PIK3CG0.43103501
65FYN0.42948221
66PDGFRA0.42151139
67PAK40.41583816
68JAK20.41327509
69CSK0.39146426
70ITK0.38912747
71MELK0.36407522
72PTK20.35812889
73PRKCD0.35108983
74GRK10.35057413
75MAP3K140.34768598
76TBK10.34556730
77BTK0.33624664
78IKBKE0.32452865
79CDK60.32237190
80ABL20.32215032
81KSR20.30860373
82TEC0.30284740
83SYK0.30116860
84CSF1R0.29259230
85BMX0.28089574
86NEK60.26618140
87MAP3K30.26542523
88CAMK2B0.26282941
89MAPKAPK20.26175903
90CAMK2G0.25871902
91JAK30.25301819
92ZAP700.22304728
93CDK190.21662461
94LYN0.21379631
95IGF1R0.20521410
96IRAK40.19346548
97KIT0.18629467
98LCK0.16755626
99MAP3K50.15068416
100PRKCQ0.14980564

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.11446235
2Vitamin digestion and absorption_Homo sapiens_hsa049774.39411128
3Fat digestion and absorption_Homo sapiens_hsa049754.24363032
4Renin-angiotensin system_Homo sapiens_hsa046144.15311992
5Caffeine metabolism_Homo sapiens_hsa002322.67620716
6Protein digestion and absorption_Homo sapiens_hsa049742.67050993
7Mineral absorption_Homo sapiens_hsa049782.60241195
8Starch and sucrose metabolism_Homo sapiens_hsa005002.54131098
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.48015742
10Histidine metabolism_Homo sapiens_hsa003402.26202766
11Arginine biosynthesis_Homo sapiens_hsa002202.25740256
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24887854
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.19591851
14Galactose metabolism_Homo sapiens_hsa000522.07779684
15Drug metabolism - other enzymes_Homo sapiens_hsa009831.95264923
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.89944210
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89223590
18Linoleic acid metabolism_Homo sapiens_hsa005911.88603119
19Retinol metabolism_Homo sapiens_hsa008301.87894203
20Fructose and mannose metabolism_Homo sapiens_hsa000511.86138989
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83744902
22Chemical carcinogenesis_Homo sapiens_hsa052041.81074063
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77058434
24PPAR signaling pathway_Homo sapiens_hsa033201.74209468
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.74202404
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.62628760
27Bile secretion_Homo sapiens_hsa049761.62454420
28Sulfur metabolism_Homo sapiens_hsa009201.49578144
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.49375478
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.48558847
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.39816212
32Arachidonic acid metabolism_Homo sapiens_hsa005901.32298809
33Arginine and proline metabolism_Homo sapiens_hsa003301.26712216
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.25565766
35Glycerolipid metabolism_Homo sapiens_hsa005611.22186084
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15581222
37Tryptophan metabolism_Homo sapiens_hsa003801.12038090
38Fatty acid degradation_Homo sapiens_hsa000711.08339269
39Ether lipid metabolism_Homo sapiens_hsa005651.04872206
40Asthma_Homo sapiens_hsa053101.01817919
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.00789705
42Phenylalanine metabolism_Homo sapiens_hsa003600.83205376
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82832524
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81952503
45Pancreatic secretion_Homo sapiens_hsa049720.79402379
46Sphingolipid metabolism_Homo sapiens_hsa006000.77213566
47Allograft rejection_Homo sapiens_hsa053300.73529973
48Autoimmune thyroid disease_Homo sapiens_hsa053200.68105746
49Graft-versus-host disease_Homo sapiens_hsa053320.65150837
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62668265
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.61164550
52Glutathione metabolism_Homo sapiens_hsa004800.56392019
53Staphylococcus aureus infection_Homo sapiens_hsa051500.55116587
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52202048
55Fatty acid biosynthesis_Homo sapiens_hsa000610.50236491
56Renin secretion_Homo sapiens_hsa049240.48682143
57Fatty acid metabolism_Homo sapiens_hsa012120.48275474
58Type I diabetes mellitus_Homo sapiens_hsa049400.47264246
59Peroxisome_Homo sapiens_hsa041460.43809263
60ABC transporters_Homo sapiens_hsa020100.36971592
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35217345
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33910247
63Folate biosynthesis_Homo sapiens_hsa007900.33501169
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32878892
65Thyroid hormone synthesis_Homo sapiens_hsa049180.32488660
66Insulin resistance_Homo sapiens_hsa049310.32482626
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.31103519
68Antigen processing and presentation_Homo sapiens_hsa046120.29956712
69Other glycan degradation_Homo sapiens_hsa005110.26702839
70Tyrosine metabolism_Homo sapiens_hsa003500.26626409
71Leishmaniasis_Homo sapiens_hsa051400.26544383
72Pentose phosphate pathway_Homo sapiens_hsa000300.22123906
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.21150199
74Cocaine addiction_Homo sapiens_hsa050300.20104913
75Hepatitis C_Homo sapiens_hsa051600.19663590
76Metabolic pathways_Homo sapiens_hsa011000.16409585
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.15363742
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.14555823
79Glucagon signaling pathway_Homo sapiens_hsa049220.12960849
80Pertussis_Homo sapiens_hsa051330.12168297
81Tight junction_Homo sapiens_hsa045300.11739657
82Toxoplasmosis_Homo sapiens_hsa051450.10854760
83Insulin secretion_Homo sapiens_hsa049110.10445616
84Serotonergic synapse_Homo sapiens_hsa047260.10395068
85Hematopoietic cell lineage_Homo sapiens_hsa046400.09337864
86Viral myocarditis_Homo sapiens_hsa054160.09135983
87Biosynthesis of amino acids_Homo sapiens_hsa012300.08837611
88Carbon metabolism_Homo sapiens_hsa012000.08738351
89African trypanosomiasis_Homo sapiens_hsa051430.07794481
90GnRH signaling pathway_Homo sapiens_hsa049120.07522594
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.06901714
92Amphetamine addiction_Homo sapiens_hsa050310.06348076
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.05678674
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05654570
95Amoebiasis_Homo sapiens_hsa051460.02231983
96Sulfur relay system_Homo sapiens_hsa041220.02228742
97Pyruvate metabolism_Homo sapiens_hsa006200.02084869
98Chemokine signaling pathway_Homo sapiens_hsa040620.02055214
99Influenza A_Homo sapiens_hsa051640.01014078
100Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0002372

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »