MUC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal epithelial cell development (GO:0060576)9.05891574
2intestinal absorption (GO:0050892)7.69125403
3bile acid and bile salt transport (GO:0015721)7.02889722
4bundle of His cell to Purkinje myocyte communication (GO:0086069)6.74085498
5regulation of guanylate cyclase activity (GO:0031282)6.32698288
6lung secretory cell differentiation (GO:0061140)6.30099127
7regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.20565747
8sulfation (GO:0051923)5.95199914
9actin filament depolymerization (GO:0030042)5.86985927
10positive regulation of respiratory burst (GO:0060267)5.86111106
11* O-glycan processing (GO:0016266)5.67633092
12sulfate transmembrane transport (GO:1902358)5.57986720
13sulfur amino acid catabolic process (GO:0000098)5.33408857
14regulation of bile acid biosynthetic process (GO:0070857)5.13841100
15glomerular filtration (GO:0003094)5.04546370
16NADH metabolic process (GO:0006734)4.99721903
17regulation of cellular extravasation (GO:0002691)4.93710610
18purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.90441668
193-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.90441668
20intestinal cholesterol absorption (GO:0030299)4.82763044
21hepatocyte apoptotic process (GO:0097284)4.75647685
22nucleotide-sugar metabolic process (GO:0009225)4.74215802
23flavonoid metabolic process (GO:0009812)4.63000645
24renal filtration (GO:0097205)4.60960782
25glandular epithelial cell differentiation (GO:0002067)4.58247377
26antibacterial humoral response (GO:0019731)4.57914236
27sulfate transport (GO:0008272)4.51828144
28nucleotide-sugar biosynthetic process (GO:0009226)4.48327614
29antimicrobial humoral response (GO:0019730)4.43337713
30pyrimidine-containing compound transmembrane transport (GO:0072531)4.36209822
31bicarbonate transport (GO:0015701)4.26460589
32sperm capacitation (GO:0048240)4.26353083
33regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.22959617
34endocrine process (GO:0050886)4.22959617
35regulation of systemic arterial blood pressure by hormone (GO:0001990)4.22959617
36epoxygenase P450 pathway (GO:0019373)4.22798418
37antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.21881951
38vitamin A metabolic process (GO:0006776)4.11208103
39fat-soluble vitamin biosynthetic process (GO:0042362)4.10414056
40positive regulation of guanylate cyclase activity (GO:0031284)4.10142036
41urea cycle (GO:0000050)4.04979331
42* maintenance of gastrointestinal epithelium (GO:0030277)4.04295348
43regulation of cholesterol homeostasis (GO:2000188)4.03529236
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.02560588
45low-density lipoprotein particle remodeling (GO:0034374)4.00529493
46angiotensin maturation (GO:0002003)3.98986922
47positive regulation of pseudopodium assembly (GO:0031274)3.95369573
48auditory receptor cell differentiation (GO:0042491)3.95186508
49* digestive system process (GO:0022600)3.90438603
50regulation of systemic arterial blood pressure (GO:0003073)3.87749349
51lipoprotein transport (GO:0042953)3.87452147
52striated muscle atrophy (GO:0014891)3.87450234
53regulation of cGMP biosynthetic process (GO:0030826)3.85735251
54sulfur compound transport (GO:0072348)3.81388961
55GDP-mannose metabolic process (GO:0019673)3.81066328
56positive regulation of epidermal cell differentiation (GO:0045606)3.80908407
57amino sugar metabolic process (GO:0006040)3.78769619
58urea metabolic process (GO:0019627)3.78290040
59hemidesmosome assembly (GO:0031581)3.75602095
60negative regulation of myotube differentiation (GO:0010832)3.75488855
61galactose catabolic process (GO:0019388)3.72114828
62diacylglycerol metabolic process (GO:0046339)3.71049944
63fucosylation (GO:0036065)3.67107749
64antigen processing and presentation of endogenous antigen (GO:0019883)3.66628865
65hormone catabolic process (GO:0042447)3.64410617
66cellular response to hepatocyte growth factor stimulus (GO:0035729)3.59824004
67response to hepatocyte growth factor (GO:0035728)3.59824004
68actin filament capping (GO:0051693)3.58984202
69regulation of G0 to G1 transition (GO:0070316)3.55534241
70complement activation, classical pathway (GO:0006958)3.55194375
71* protein O-linked glycosylation (GO:0006493)3.54882794
72regulation of pseudopodium assembly (GO:0031272)3.52203495
73drug catabolic process (GO:0042737)3.52105191
74calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.51914062
75digestion (GO:0007586)3.51735090
76cellular glucuronidation (GO:0052695)3.50619306
77cellular response to epidermal growth factor stimulus (GO:0071364)3.50353507
78peptide catabolic process (GO:0043171)3.49637918
79negative regulation of keratinocyte proliferation (GO:0010839)3.47771552
80regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.46412150
81ventricular cardiac muscle cell action potential (GO:0086005)3.44473392
82cardiac conduction (GO:0061337)3.42689625
83nitrogen cycle metabolic process (GO:0071941)3.41280259
84positive regulation of Cdc42 GTPase activity (GO:0043089)3.40410385
85transcytosis (GO:0045056)3.39199823
86drug metabolic process (GO:0017144)3.39107163
87skeletal muscle adaptation (GO:0043501)3.37123298
88* epithelial structure maintenance (GO:0010669)3.35443861
89positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.34105402
90regulation of actin nucleation (GO:0051125)3.32693859
91fructose metabolic process (GO:0006000)3.31722465
92desmosome organization (GO:0002934)3.30395019
93cell communication involved in cardiac conduction (GO:0086065)3.30274626
94galactose metabolic process (GO:0006012)3.29553100
95negative regulation of cell fate commitment (GO:0010454)3.27834678
96glucuronate metabolic process (GO:0019585)3.26323345
97uronic acid metabolic process (GO:0006063)3.26323345
98regulation of RIG-I signaling pathway (GO:0039535)3.23488732
99positive regulation of fatty acid beta-oxidation (GO:0032000)3.22359589
100negative regulation of actin filament depolymerization (GO:0030835)3.21113260
101columnar/cuboidal epithelial cell development (GO:0002066)3.19183026
102nucleotide transmembrane transport (GO:1901679)3.18749281
103bile acid metabolic process (GO:0008206)3.18429557
104peptide hormone processing (GO:0016486)3.18257144
105muscle atrophy (GO:0014889)3.17396254
106lung cell differentiation (GO:0060479)3.16612966
107thrombin receptor signaling pathway (GO:0070493)3.16270679
108phosphatidylserine acyl-chain remodeling (GO:0036150)3.14986556
109virion attachment to host cell (GO:0019062)3.12651603
110adhesion of symbiont to host cell (GO:0044650)3.12651603
111eosinophil chemotaxis (GO:0048245)3.12634117
112regulation of cGMP metabolic process (GO:0030823)3.12156276
113glycosphingolipid catabolic process (GO:0046479)3.11356364
114hypotonic response (GO:0006971)3.09281649
115L-fucose metabolic process (GO:0042354)3.07162101
116L-fucose catabolic process (GO:0042355)3.07162101
117fucose catabolic process (GO:0019317)3.07162101
118glycolipid catabolic process (GO:0019377)3.05156118
119lung epithelial cell differentiation (GO:0060487)3.05066320
120N-acetylglucosamine metabolic process (GO:0006044)3.03172709
121alkaloid metabolic process (GO:0009820)3.03043007
122positive regulation of epidermis development (GO:0045684)3.02982695
123vitamin transmembrane transport (GO:0035461)3.02915190
124cGMP-mediated signaling (GO:0019934)3.02374663
125kidney morphogenesis (GO:0060993)3.01477521
126positive regulation of actin filament depolymerization (GO:0030836)2.97093153
127lipoprotein metabolic process (GO:0042157)2.97000003
128positive regulation of glycoprotein biosynthetic process (GO:0010560)2.95857014
129arginine metabolic process (GO:0006525)2.95511854
130exogenous drug catabolic process (GO:0042738)2.94154211
131neurotransmitter biosynthetic process (GO:0042136)2.92420568
132phosphate ion transmembrane transport (GO:0035435)2.92163743
133glucosamine-containing compound metabolic process (GO:1901071)2.90852575
134receptor guanylyl cyclase signaling pathway (GO:0007168)2.89742679
135glucose 6-phosphate metabolic process (GO:0051156)2.86795947
136regulation of ARF GTPase activity (GO:0032312)2.86039928
137ethanol oxidation (GO:0006069)2.85666892
138phospholipid scrambling (GO:0017121)2.85356751
139nucleoside diphosphate biosynthetic process (GO:0009133)2.84345073
140glucocorticoid biosynthetic process (GO:0006704)2.84158871
141sodium ion export (GO:0071436)2.84013966
142lipopolysaccharide biosynthetic process (GO:0009103)2.83902218
143phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.81927049
144cytoskeletal anchoring at plasma membrane (GO:0007016)2.81849002
145response to epidermal growth factor (GO:0070849)2.81428563
146multicellular organismal water homeostasis (GO:0050891)2.80591947
147sialylation (GO:0097503)2.79809427
148renal system process involved in regulation of blood volume (GO:0001977)2.79768515
149regulation of respiratory burst (GO:0060263)2.79003512
150regulation of pH (GO:0006885)2.78637749
151lipid translocation (GO:0034204)2.78421483
152phospholipid translocation (GO:0045332)2.78421483
153regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.78341407
154regulation of intracellular pH (GO:0051453)2.75956039
155regulation of heart rate by cardiac conduction (GO:0086091)2.74971685
156membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.70143708
157phosphatidylinositol acyl-chain remodeling (GO:0036149)2.70137819
158negative regulation of protein tyrosine kinase activity (GO:0061099)2.67573665
159oligosaccharide biosynthetic process (GO:0009312)2.67148044
160regulation of vitamin metabolic process (GO:0030656)2.64999913
161UDP-N-acetylglucosamine metabolic process (GO:0006047)10.3944811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.54554860
2* CDX2_20551321_ChIP-Seq_CACO-2_Human4.78816644
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.80520243
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.64954973
5CDX2_19796622_ChIP-Seq_MESCs_Mouse3.35505224
6SOX2_20726797_ChIP-Seq_SW620_Human2.93850924
7GATA4_25053715_ChIP-Seq_YYC3_Human2.86189911
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.73044745
9* GATA6_25053715_ChIP-Seq_YYC3_Human2.72071490
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.59703336
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.58732539
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.40167548
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.26094993
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.24051513
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.20949753
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.18305174
17CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.15731248
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.15133612
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.12522276
20FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.11545993
21FOXO3_23340844_ChIP-Seq_DLD1_Human2.08374185
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.07438156
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.03828330
24RUNX1_27514584_Chip-Seq_MCF-7_Human2.00478891
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.98489017
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.95547023
27LXR_22158963_ChIP-Seq_LIVER_Mouse1.93241329
28RXR_22158963_ChIP-Seq_LIVER_Mouse1.91746754
29KLF5_25053715_ChIP-Seq_YYC3_Human1.86357967
30* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.84006917
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.83902409
32ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.82589340
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82539903
34TCF4_18268006_ChIP-ChIP_LS174T_Human1.75756210
35ZNF263_19887448_ChIP-Seq_K562_Human1.66781229
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.66615793
37SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.66330961
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65585352
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64253395
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.63218435
41* RACK7_27058665_Chip-Seq_MCF-7_Human1.62899961
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59758309
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56905312
44* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53184937
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.52231357
46* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49349463
47* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48272235
48* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.48193387
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.46578135
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.41770832
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38621661
52GATA2_19941826_ChIP-Seq_K562_Human1.37303565
53FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.33687657
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33064060
55BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.31917846
56AR_21909140_ChIP-Seq_LNCAP_Human1.31481176
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30987481
58* DROSHA_22980978_ChIP-Seq_HELA_Human1.29770200
59BCAT_22108803_ChIP-Seq_LS180_Human1.29162888
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.27103376
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21495663
62CLOCK_20551151_ChIP-Seq_293T_Human1.20875987
63FOXA1_25552417_ChIP-Seq_VCAP_Human1.20856493
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19468359
65AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19445975
66VDR_22108803_ChIP-Seq_LS180_Human1.18670467
67ATF3_27146783_Chip-Seq_COLON_Human1.17484390
68GATA1_22025678_ChIP-Seq_K562_Human1.16448372
69FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.16190457
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13557804
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13555655
72BCL6_27268052_Chip-Seq_Bcells_Human1.11015771
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10496667
74SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10351226
75SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10351226
76CREB1_26743006_Chip-Seq_LNCaP_Human1.08523832
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06965713
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.05665187
79FOXA2_19822575_ChIP-Seq_HepG2_Human1.05338769
80SA1_27219007_Chip-Seq_Bcells_Human1.04694976
81ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03240679
82BCOR_27268052_Chip-Seq_Bcells_Human1.02554848
83IRF8_21731497_ChIP-ChIP_J774_Mouse1.00677352
84GATA3_24758297_ChIP-Seq_MCF-7_Human1.00466015
85GATA1_19941826_ChIP-Seq_K562_Human0.99782040
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99763002
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98847329
88WDR5_24793694_ChIP-Seq_LNCAP_Human0.97764017
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96616469
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96405653
91CDX2_22108803_ChIP-Seq_LS180_Human0.96309311
92* CTCF_27219007_Chip-Seq_Bcells_Human0.96098741
93JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95759109
94CEBPB_22108803_ChIP-Seq_LS180_Human0.95593140
95HNF4A_19822575_ChIP-Seq_HepG2_Human0.95489858
96SMC4_20622854_ChIP-Seq_HELA_Human0.95274949
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95068454
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94222570
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.93569722
100JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93172549
101IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91952374
102* TP63_22573176_ChIP-Seq_HFKS_Human0.89866826
103P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88728499
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88347679
105RXR_22108803_ChIP-Seq_LS180_Human0.87916464
106EGR1_19032775_ChIP-ChIP_M12_Human0.87447596
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86752476
108* E2F1_20622854_ChIP-Seq_HELA_Human0.86085741
109CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85978327
110RAD21_21589869_ChIP-Seq_MESCs_Mouse0.85513101
111TP53_16413492_ChIP-PET_HCT116_Human0.85425263
112NANOG_20526341_ChIP-Seq_ESCs_Human0.84930642
113PHF8_20622854_ChIP-Seq_HELA_Human0.84634167
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84557406
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84340653
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.83393520
117ELF5_23300383_ChIP-Seq_T47D_Human0.82718415
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82197686
119STAT1_20625510_ChIP-Seq_HELA_Human0.81596413
120LXR_22292898_ChIP-Seq_THP-1_Human0.81352885
121PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81226278
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81217180
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80368440
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80116187
125FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80000092
126FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.79717257
127HIF1A_21447827_ChIP-Seq_MCF-7_Human0.79452153
128GATA1_26923725_Chip-Seq_HPCs_Mouse0.78907833
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78829359
130NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.78803415
131VDR_24787735_ChIP-Seq_THP-1_Human0.78616753
132* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77175162
133AHR_22903824_ChIP-Seq_MCF-7_Human0.77102109
134SOX9_24532713_ChIP-Seq_HFSC_Mouse0.76400369
135TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76124127

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.34433718
2MP0004264_abnormal_extraembryonic_tissu4.25255474
3MP0005360_urolithiasis4.18270154
4* MP0003866_abnormal_defecation3.93818484
5MP0003868_abnormal_feces_composition3.57307529
6MP0001873_stomach_inflammation3.56234524
7MP0000462_abnormal_digestive_system3.53238906
8* MP0010155_abnormal_intestine_physiology3.48381342
9MP0005085_abnormal_gallbladder_physiolo3.42835776
10MP0002822_catalepsy3.28821693
11* MP0001663_abnormal_digestive_system3.23356812
12MP0000490_abnormal_crypts_of3.09550823
13* MP0005381_digestive/alimentary_phenotyp3.03274956
14* MP0001666_abnormal_nutrient_absorption2.96470866
15MP0010352_gastrointestinal_tract_polyps2.95200442
16MP0008875_abnormal_xenobiotic_pharmacok2.86247810
17MP0005365_abnormal_bile_salt2.86193209
18MP0001664_abnormal_digestion2.82914743
19MP0003705_abnormal_hypodermis_morpholog2.77786307
20MP0008004_abnormal_stomach_pH2.64846292
21* MP0000477_abnormal_intestine_morphology2.64266234
22MP0003878_abnormal_ear_physiology2.63403245
23MP0005377_hearing/vestibular/ear_phenot2.63403245
24MP0006054_spinal_hemorrhage2.40954455
25MP0000537_abnormal_urethra_morphology2.21342138
26MP0005167_abnormal_blood-brain_barrier2.16578389
27MP0003252_abnormal_bile_duct2.12377227
28MP0003300_gastrointestinal_ulcer2.05886220
29MP0004043_abnormal_pH_regulation1.99167753
30MP0003283_abnormal_digestive_organ1.93937557
31MP0002277_abnormal_respiratory_mucosa1.93240661
32MP0002139_abnormal_hepatobiliary_system1.81077059
33MP0005409_darkened_coat_color1.75204769
34MP0001765_abnormal_ion_homeostasis1.74900103
35MP0000538_abnormal_urinary_bladder1.66418676
36MP0001849_ear_inflammation1.54093220
37MP0005166_decreased_susceptibility_to1.52828737
38MP0004147_increased_porphyrin_level1.49428507
39MP0004858_abnormal_nervous_system1.49237411
40MP0004782_abnormal_surfactant_physiolog1.48384995
41MP0002876_abnormal_thyroid_physiology1.47542107
42MP0002138_abnormal_hepatobiliary_system1.46675345
43MP0000566_synostosis1.37636977
44MP0010678_abnormal_skin_adnexa1.34406880
45MP0009780_abnormal_chondrocyte_physiolo1.30931554
46MP0000467_abnormal_esophagus_morphology1.30823439
47MP0002796_impaired_skin_barrier1.28176206
48MP0010329_abnormal_lipoprotein_level1.27924154
49MP0005310_abnormal_salivary_gland1.23049437
50MP0000470_abnormal_stomach_morphology1.21376823
51MP0005275_abnormal_skin_tensile1.16641563
52MP0001485_abnormal_pinna_reflex1.16077271
53MP0008438_abnormal_cutaneous_collagen1.15044268
54MP0009643_abnormal_urine_homeostasis1.14918227
55MP0005636_abnormal_mineral_homeostasis1.12039440
56MP0005257_abnormal_intraocular_pressure1.08740868
57MP0005666_abnormal_adipose_tissue1.08290837
58MP0004019_abnormal_vitamin_homeostasis1.01845880
59MP0009379_abnormal_foot_pigmentation1.00135128
60MP0003191_abnormal_cellular_cholesterol0.97780287
61MP0003183_abnormal_peptide_metabolism0.96839804
62MP0002166_altered_tumor_susceptibility0.96497619
63MP0009384_cardiac_valve_regurgitation0.93231658
64MP0003453_abnormal_keratinocyte_physiol0.90489392
65MP0005670_abnormal_white_adipose0.90399490
66MP0001764_abnormal_homeostasis0.90394995
67MP0003724_increased_susceptibility_to0.88005439
68MP0004947_skin_inflammation0.87073637
69MP0009785_altered_susceptibility_to0.86055150
70MP0000579_abnormal_nail_morphology0.85626660
71MP0001243_abnormal_dermal_layer0.83880923
72MP0005025_abnormal_response_to0.83070273
73MP0004484_altered_response_of0.82479040
74MP0003329_amyloid_beta_deposits0.82267133
75MP0001835_abnormal_antigen_presentation0.81707656
76MP0005451_abnormal_body_composition0.80827923
77MP0008872_abnormal_physiological_respon0.80502325
78MP0003303_peritoneal_inflammation0.79185299
79MP0005367_renal/urinary_system_phenotyp0.77959139
80MP0000516_abnormal_urinary_system0.77959139
81MP0005448_abnormal_energy_balance0.77743378
82MP0005165_increased_susceptibility_to0.76951871
83MP0005387_immune_system_phenotype0.75763416
84MP0001790_abnormal_immune_system0.75763416
85MP0003879_abnormal_hair_cell0.74748380
86MP0006082_CNS_inflammation0.73777199
87MP0004185_abnormal_adipocyte_glucose0.73153842
88MP0005501_abnormal_skin_physiology0.72995515
89MP0005187_abnormal_penis_morphology0.72979281
90MP0005375_adipose_tissue_phenotype0.72759554
91MP0002118_abnormal_lipid_homeostasis0.71711755
92MP0009764_decreased_sensitivity_to0.71224678
93MP0004270_analgesia0.71177336
94MP0001756_abnormal_urination0.68102863
95MP0009840_abnormal_foam_cell0.68088941
96MP0002060_abnormal_skin_morphology0.67186977
97MP0002098_abnormal_vibrissa_morphology0.67160371
98MP0001216_abnormal_epidermal_layer0.66708586
99MP0000609_abnormal_liver_physiology0.66441168
100MP0003436_decreased_susceptibility_to0.65787402
101MP0002006_tumorigenesis0.65676299
102MP0002971_abnormal_brown_adipose0.64636659
103MP0010307_abnormal_tumor_latency0.62229520
104MP0005584_abnormal_enzyme/coenzyme_acti0.62132184
105MP0001188_hyperpigmentation0.60551021
106MP0005058_abnormal_lysosome_morphology0.60312278
107MP0008469_abnormal_protein_level0.60209487
108MP0002136_abnormal_kidney_physiology0.59972453
109MP0005319_abnormal_enzyme/_coenzyme0.59456890
110* MP0001845_abnormal_inflammatory_respons0.58202468
111MP0000249_abnormal_blood_vessel0.57480185
112MP0008873_increased_physiological_sensi0.57246475
113MP0003806_abnormal_nucleotide_metabolis0.56717071
114MP0003045_fibrosis0.56144053
115* MP0000465_gastrointestinal_hemorrhage0.55940270
116MP0001800_abnormal_humoral_immune0.55867237
117MP0002089_abnormal_postnatal_growth/wei0.55366834
118MP0000003_abnormal_adipose_tissue0.53879074
119MP0000678_abnormal_parathyroid_gland0.52497460
120MP0000230_abnormal_systemic_arterial0.51817896
121MP0009053_abnormal_anal_canal0.51329923
122MP0000613_abnormal_salivary_gland0.51146495
123MP0003566_abnormal_cell_adhesion0.50795790
124MP0005023_abnormal_wound_healing0.50541589
125MP0002896_abnormal_bone_mineralization0.50485879
126MP0010386_abnormal_urinary_bladder0.48757176
127MP0001501_abnormal_sleep_pattern0.47597729
128MP0000013_abnormal_adipose_tissue0.45705500
129MP0001440_abnormal_grooming_behavior0.44430270
130MP0003941_abnormal_skin_development0.43321617
131MP0000377_abnormal_hair_follicle0.43023514
132MP0010771_integument_phenotype0.40583823
133MP0005076_abnormal_cell_differentiation0.39216580
134MP0005332_abnormal_amino_acid0.38723793
135MP0003567_abnormal_fetal_cardiomyocyte0.37631871
136MP0003075_altered_response_to0.36984212

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)8.00879104
2Right ventricular cardiomyopathy (HP:0011663)7.25038790
3Hyperactive renin-angiotensin system (HP:0000841)6.52347988
4Metabolic alkalosis (HP:0200114)6.38956137
5Abdominal distention (HP:0003270)5.17146177
6Malnutrition (HP:0004395)4.69240611
7Flat acetabular roof (HP:0003180)4.47497274
8Chronic diarrhea (HP:0002028)4.45882302
9Abnormality of renin-angiotensin system (HP:0000847)4.37446022
10Abnormality of chloride homeostasis (HP:0011422)4.31637785
11Hemorrhage of the eye (HP:0011885)4.20932704
12Decreased circulating renin level (HP:0003351)4.17124682
13Mildly elevated creatine phosphokinase (HP:0008180)4.00793103
14Systemic lupus erythematosus (HP:0002725)3.95957363
15Gastrointestinal dysmotility (HP:0002579)3.91734925
16Conjugated hyperbilirubinemia (HP:0002908)3.88114847
17Bundle branch block (HP:0011710)3.64685781
18Abnormality of the 1st metacarpal (HP:0010009)3.52054716
19Abnormal tarsal ossification (HP:0008369)3.43998811
20Syncope (HP:0001279)3.41388140
21Enlarged epiphyses (HP:0010580)3.41065233
22Abnormal foot bone ossification (HP:0010675)3.31141772
23Micronodular cirrhosis (HP:0001413)3.28253928
24Fat malabsorption (HP:0002630)3.14079529
25Hyperparathyroidism (HP:0000843)3.12709004
26Progressive sensorineural hearing impairment (HP:0000408)3.06231493
27Abnormality of the distal phalanx of the thumb (HP:0009617)3.05940651
28Abnormal hair laboratory examination (HP:0003328)3.04716380
29Hyperaldosteronism (HP:0000859)3.02721299
30Abnormality of glutamine family amino acid metabolism (HP:0010902)3.00923353
31Aortic aneurysm (HP:0004942)2.99793582
32Palpitations (HP:0001962)2.99485589
33Alkalosis (HP:0001948)2.95546685
34Intrahepatic cholestasis (HP:0001406)2.92042760
35Abnormality of the vitamin B12 metabolism (HP:0004341)2.87696614
36Woolly hair (HP:0002224)2.87207044
37Hyperkalemia (HP:0002153)2.82529996
38Wide cranial sutures (HP:0010537)2.82489075
39Delayed epiphyseal ossification (HP:0002663)2.81467751
40Progressive hearing impairment (HP:0001730)2.79653296
41Milia (HP:0001056)2.77161187
42Abnormal biliary tract morphology (HP:0012440)2.69963060
43Abnormality of vitamin B metabolism (HP:0004340)2.66995863
44Rectal prolapse (HP:0002035)2.66001195
45Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.63979383
46Short 1st metacarpal (HP:0010034)2.63979383
47Focal segmental glomerulosclerosis (HP:0000097)2.63948019
48Petechiae (HP:0000967)2.63466159
49Dehydration (HP:0001944)2.60305212
50Eczematoid dermatitis (HP:0000976)2.58828442
51Abnormality of small intestinal villus morphology (HP:0011472)2.58025040
52Villous atrophy (HP:0011473)2.58025040
53Ureteral stenosis (HP:0000071)2.56321168
54Abnormality of the gastric mucosa (HP:0004295)2.54718664
55Abnormality of the costochondral junction (HP:0000919)2.53110741
56Tibial bowing (HP:0002982)2.49194192
57Hypokalemia (HP:0002900)2.49041393
58Pili torti (HP:0003777)2.47821531
59Pigmentary retinal degeneration (HP:0001146)2.47246401
60Biliary tract neoplasm (HP:0100574)2.46384418
61Abnormality of carpal bone ossification (HP:0006257)2.45161856
62Glomerulonephritis (HP:0000099)2.44211292
63Hoarse voice (HP:0001609)2.42532092
64Congenital sensorineural hearing impairment (HP:0008527)2.42093176
65Abnormality of monocarboxylic acid metabolism (HP:0010996)2.41057210
66Abnormal vertebral ossification (HP:0100569)2.40135449
67Abnormality of pyrimidine metabolism (HP:0004353)2.39911658
68Ventricular tachycardia (HP:0004756)2.38646746
69Distal lower limb amyotrophy (HP:0008944)2.37899038
70Ureteral obstruction (HP:0006000)2.35871770
71Short phalanx of the thumb (HP:0009660)2.35789610
72Prolonged QT interval (HP:0001657)2.35559506
73Protuberant abdomen (HP:0001538)2.35325145
74Flattened epiphyses (HP:0003071)2.34860704
75Thin bony cortex (HP:0002753)2.31572699
76Abnormality of vitamin metabolism (HP:0100508)2.30371739
77Symphalangism affecting the phalanges of the hand (HP:0009773)2.30281808
78Abnormality of complement system (HP:0005339)2.29953169
79Atrophic scars (HP:0001075)2.29055259
80Confusion (HP:0001289)2.28320345
81Abnormal cartilage morphology (HP:0002763)2.26729268
82Ventricular fibrillation (HP:0001663)2.25962952
83Abnormality of proline metabolism (HP:0010907)2.25181227
84Hydroxyprolinuria (HP:0003080)2.25181227
85Fragile nails (HP:0001808)2.24535676
86Glomerulosclerosis (HP:0000096)2.20596649
87Pustule (HP:0200039)2.19900227
88Distal upper limb amyotrophy (HP:0007149)2.18997829
89Upper limb amyotrophy (HP:0009129)2.18997829
90Neonatal short-limb short stature (HP:0008921)2.18730354
91Nephritis (HP:0000123)2.17363132
92Bilateral sensorineural hearing impairment (HP:0008619)2.15897725
93Hyponatremia (HP:0002902)2.13838204
94Curly hair (HP:0002212)2.12995994
95Abnormal atrioventricular conduction (HP:0005150)2.12842480
96Hypophosphatemia (HP:0002148)2.12544705
97Microretrognathia (HP:0000308)2.12308964
98Heart block (HP:0012722)2.11164246
99Abnormal hand bone ossification (HP:0010660)2.10595297
100Cupped ribs (HP:0000887)2.09396621
101Hypotension (HP:0002615)2.09057234
102Abnormality of potassium homeostasis (HP:0011042)2.08244135
103Esophageal varix (HP:0002040)2.08037881
104Widely patent fontanelles and sutures (HP:0004492)2.07135819
105Cone-rod dystrophy (HP:0000548)2.04512353
106Nephrolithiasis (HP:0000787)2.04287366
107Aortic dissection (HP:0002647)2.04044732
108Abnormality of the 2nd finger (HP:0004100)2.01183253
109Adrenal overactivity (HP:0002717)2.01045926
110Acanthocytosis (HP:0001927)2.00427985
111Long clavicles (HP:0000890)1.99720971
112Complement deficiency (HP:0004431)1.99379482
113Plantar hyperkeratosis (HP:0007556)1.98512930
114Proximal tubulopathy (HP:0000114)1.98026526
115Vertebral clefting (HP:0008428)1.97321634
116Abnormal ossification of hand bones (HP:0005921)1.95670806
117Glycosuria (HP:0003076)1.93943421
118Abnormality of urine glucose concentration (HP:0011016)1.93943421
119Segmental peripheral demyelination/remyelination (HP:0003481)1.93837970
120Neoplasm of the rectum (HP:0100743)1.93315341
121Myopathic facies (HP:0002058)1.93178984
122Broad metatarsal (HP:0001783)1.92870803
123Bone pain (HP:0002653)1.92707342
124Metaphyseal irregularity (HP:0003025)1.91572196
125Onycholysis (HP:0001806)1.90530020
126Axonal loss (HP:0003447)1.90343315
127Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.89233280
128Cerebral aneurysm (HP:0004944)1.88619331
129Symptomatic seizures (HP:0011145)1.87241033
130Fragile skin (HP:0001030)1.86588636
131Nausea (HP:0002018)1.86000660
132Cerebral palsy (HP:0100021)1.85062125
133Spinal cord compression (HP:0002176)1.84722790
134Xanthomatosis (HP:0000991)1.83778635
135Vertebral hypoplasia (HP:0008417)1.83440331
136Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.83440331
137Ventricular arrhythmia (HP:0004308)1.82937077
138Alopecia of scalp (HP:0002293)1.82610090
139Hypobetalipoproteinemia (HP:0003563)1.81989658
140Gingivitis (HP:0000230)1.81535291
141Mask-like facies (HP:0000298)1.79532746
142Increased purine levels (HP:0004368)1.78996086
143Hyperuricemia (HP:0002149)1.78996086
144Dicarboxylic aciduria (HP:0003215)1.78981109
145Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78981109
146Abnormality of dentin (HP:0010299)1.77825650
147Abnormality of nucleobase metabolism (HP:0010932)1.76453561
148Hyperglycinuria (HP:0003108)1.74492801

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.27451134
2LMTK24.79163964
3MST44.68187924
4ACVR1B4.56157212
5MST1R3.99636518
6MYLK3.73269958
7NME13.36715544
8PIK3CA2.98725020
9PRKG22.74082143
10TESK12.72927299
11MAP2K22.59361164
12PTK62.21539903
13RIPK12.16693520
14EPHB22.13713616
15MAP3K21.93258061
16FGFR41.86200087
17GRK61.78173133
18KSR21.74549974
19OXSR11.61283267
20MAP3K101.55595586
21LIMK11.43267428
22MET1.41179477
23EPHA31.33861821
24RPS6KB21.32971942
25MAP2K11.31829483
26TAOK11.30474453
27DMPK1.24539980
28DDR21.21973563
29WNK11.18070179
30TYK21.15312491
31FER1.14988513
32STK101.14783811
33PAK41.14391118
34TNIK1.12958320
35EEF2K1.12612689
36ERN11.10232775
37LATS11.10174168
38PTK21.06227503
39MAP3K71.06137910
40RIPK41.02977517
41MATK1.02859455
42ERBB21.02588567
43CAMK2D0.93378414
44PAK20.89623286
45FGFR30.87378436
46NUAK10.86361350
47TTN0.85974353
48PRKCI0.85255134
49PRKAA20.84045501
50PAK30.82783386
51AKT30.79541248
52MAP3K80.78793676
53MAP3K10.77324096
54PRPF4B0.77289965
55CDK120.75773110
56LRRK20.73282155
57MAP3K90.73164034
58EPHB10.72327276
59MAP3K120.71318147
60EPHA20.70276481
61STK240.68412667
62MAP4K10.68246488
63NLK0.68078914
64CAMK2G0.67353805
65PIK3CG0.66885859
66MAPK110.64404734
67CAMK2B0.63099134
68PKN20.59236141
69ICK0.58993838
70WNK40.58747977
71CDC42BPA0.58481947
72TAOK30.58443255
73ROCK10.58125206
74TRIB30.55711355
75MAP3K110.54803866
76PAK10.54218492
77JAK10.51217883
78PRKAA10.51170434
79CSK0.50916066
80RET0.49865586
81BMX0.48070142
82ZAP700.47980522
83CASK0.47351832
84MAPKAPK30.46878889
85PDPK10.44439242
86TBK10.42520573
87PDGFRB0.42520206
88ITK0.40449068
89SMG10.37802347
90MAP3K140.37770454
91MAPKAPK20.37197623
92CSNK1A10.36934536
93SRC0.36278218
94DAPK30.36248262
95DYRK1B0.35737105
96FYN0.35213378
97PRKCA0.34292100
98MAP2K60.34237921
99YES10.32682495
100ROCK20.30979776
101MAP3K130.30663256
102NEK20.29857604
103IRAK10.29657966
104KIT0.29356784
105STK390.29047913
106PDK10.28836192
107BLK0.27649242
108AURKB0.27588535
109TTK0.27160585
110TRPM70.26630224
111SCYL20.26546909
112PDK20.26440019
113GSK3A0.25777596
114CDK60.25723625
115PDK40.25445397
116PDK30.25445397
117NEK10.25436696
118JAK30.25364607
119MUSK0.24892038
120EPHA40.24838540
121PRKCZ0.24183434
122IKBKE0.24078438
123PDGFRA0.23771894
124JAK20.23270611
125STK30.22491475
126PRKACG0.22418514
127IGF1R0.21480691
128PRKD20.21287223
129CSF1R0.20884465
130MELK0.20425822
131SGK10.20306365
132MAP3K60.19857656
133TEC0.19644655
134SIK10.18980206
135CAMKK10.18867765
136RPS6KA20.18357319
137TESK20.18053339
138PRKCD0.15954865
139LYN0.15887113
140ABL20.15398264

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009206.48932357
2Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005124.02969877
3Mineral absorption_Homo sapiens_hsa049783.93433530
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.18690400
5Fat digestion and absorption_Homo sapiens_hsa049753.16203037
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.05840949
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.93928616
8Bile secretion_Homo sapiens_hsa049762.62086220
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.22215391
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.17196787
11Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.14487295
12Renin-angiotensin system_Homo sapiens_hsa046141.96032875
13Galactose metabolism_Homo sapiens_hsa000521.84435624
14Histidine metabolism_Homo sapiens_hsa003401.75787681
15Caffeine metabolism_Homo sapiens_hsa002321.70940835
16Pancreatic secretion_Homo sapiens_hsa049721.70496419
17Retinol metabolism_Homo sapiens_hsa008301.62170948
18Fructose and mannose metabolism_Homo sapiens_hsa000511.54484095
19Starch and sucrose metabolism_Homo sapiens_hsa005001.51028125
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.48506666
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.48426265
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.48168865
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44881922
24Protein digestion and absorption_Homo sapiens_hsa049741.37515462
25Asthma_Homo sapiens_hsa053101.32010742
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29733489
27Tight junction_Homo sapiens_hsa045301.27101230
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26699708
29PPAR signaling pathway_Homo sapiens_hsa033201.24831615
30Linoleic acid metabolism_Homo sapiens_hsa005911.23372611
31Tryptophan metabolism_Homo sapiens_hsa003801.16914953
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.16775889
33Other glycan degradation_Homo sapiens_hsa005111.13127151
34Staphylococcus aureus infection_Homo sapiens_hsa051501.07527926
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03321597
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02253557
37Allograft rejection_Homo sapiens_hsa053300.98783954
38Butanoate metabolism_Homo sapiens_hsa006500.96302572
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95320563
40Autoimmune thyroid disease_Homo sapiens_hsa053200.95252953
41Fatty acid degradation_Homo sapiens_hsa000710.93313149
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93100404
43Graft-versus-host disease_Homo sapiens_hsa053320.89296864
44Vitamin digestion and absorption_Homo sapiens_hsa049770.87929858
45Gastric acid secretion_Homo sapiens_hsa049710.84775766
46Leukocyte transendothelial migration_Homo sapiens_hsa046700.80797306
47Salivary secretion_Homo sapiens_hsa049700.79898875
48Glycerolipid metabolism_Homo sapiens_hsa005610.79614105
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79338321
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76320523
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76201505
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75569370
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.75326054
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74533223
55Salmonella infection_Homo sapiens_hsa051320.73929951
56Type I diabetes mellitus_Homo sapiens_hsa049400.70197845
57Glutathione metabolism_Homo sapiens_hsa004800.69716651
58Folate biosynthesis_Homo sapiens_hsa007900.67265721
59Thyroid cancer_Homo sapiens_hsa052160.67189295
60Renin secretion_Homo sapiens_hsa049240.66094154
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.65730962
62Adherens junction_Homo sapiens_hsa045200.65090089
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.63685517
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63620098
65Thyroid hormone synthesis_Homo sapiens_hsa049180.61621196
66ABC transporters_Homo sapiens_hsa020100.59610712
67Ether lipid metabolism_Homo sapiens_hsa005650.59546972
68Antigen processing and presentation_Homo sapiens_hsa046120.54557235
69Nitrogen metabolism_Homo sapiens_hsa009100.53912451
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.53375413
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52721496
72Carbon metabolism_Homo sapiens_hsa012000.51668392
73Pentose phosphate pathway_Homo sapiens_hsa000300.51584861
74Leishmaniasis_Homo sapiens_hsa051400.51495395
75Pyruvate metabolism_Homo sapiens_hsa006200.49303761
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49287104
77N-Glycan biosynthesis_Homo sapiens_hsa005100.47650424
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46842144
79Hepatitis C_Homo sapiens_hsa051600.46033519
80Arachidonic acid metabolism_Homo sapiens_hsa005900.45750761
81Sphingolipid metabolism_Homo sapiens_hsa006000.44601508
82Insulin secretion_Homo sapiens_hsa049110.42461279
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42189224
84Arginine and proline metabolism_Homo sapiens_hsa003300.41001251
85Bladder cancer_Homo sapiens_hsa052190.39319852
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38855755
87Pertussis_Homo sapiens_hsa051330.38696916
88beta-Alanine metabolism_Homo sapiens_hsa004100.37279300
89Chemical carcinogenesis_Homo sapiens_hsa052040.35575562
90Toxoplasmosis_Homo sapiens_hsa051450.32249117
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31665430
92Propanoate metabolism_Homo sapiens_hsa006400.30604782
93African trypanosomiasis_Homo sapiens_hsa051430.29629442
94Viral myocarditis_Homo sapiens_hsa054160.29169343
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29001584
96Peroxisome_Homo sapiens_hsa041460.27677644
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27609000
98GnRH signaling pathway_Homo sapiens_hsa049120.26576597
99Insulin resistance_Homo sapiens_hsa049310.26125451
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.24905674
101* Amoebiasis_Homo sapiens_hsa051460.23342879
102Selenocompound metabolism_Homo sapiens_hsa004500.23124301
103Phenylalanine metabolism_Homo sapiens_hsa003600.22918031
104Influenza A_Homo sapiens_hsa051640.22099664
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.21891695
106Sulfur relay system_Homo sapiens_hsa041220.20837898
107Type II diabetes mellitus_Homo sapiens_hsa049300.20649550
108Dorso-ventral axis formation_Homo sapiens_hsa043200.20521780
109Fatty acid biosynthesis_Homo sapiens_hsa000610.19940541
110Fatty acid metabolism_Homo sapiens_hsa012120.18827160
111Metabolic pathways_Homo sapiens_hsa011000.18791956
112Arginine biosynthesis_Homo sapiens_hsa002200.18763755
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.18594065
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17764187
115Glucagon signaling pathway_Homo sapiens_hsa049220.16506903
116Alzheimers disease_Homo sapiens_hsa050100.15990172
117Choline metabolism in cancer_Homo sapiens_hsa052310.15382521
118Gap junction_Homo sapiens_hsa045400.15070709
119Inositol phosphate metabolism_Homo sapiens_hsa005620.15062174
120Ovarian steroidogenesis_Homo sapiens_hsa049130.14491237
121Hematopoietic cell lineage_Homo sapiens_hsa046400.14050789
122Endometrial cancer_Homo sapiens_hsa052130.13910815
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.12546154
124Cardiac muscle contraction_Homo sapiens_hsa042600.12427487
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.12311369
126TNF signaling pathway_Homo sapiens_hsa046680.11894792
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10685114
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.10038864
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.10011242
130Focal adhesion_Homo sapiens_hsa045100.10005982
131* Vibrio cholerae infection_Homo sapiens_hsa051100.08964324
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.08757944

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