MUC20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)9.92882005
2motile cilium assembly (GO:0044458)9.35113407
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.88894147
4epithelial cilium movement (GO:0003351)8.83875244
5cellular copper ion homeostasis (GO:0006878)8.12549337
6axoneme assembly (GO:0035082)7.23996487
7diterpenoid biosynthetic process (GO:0016102)7.05919495
8primary alcohol catabolic process (GO:0034310)6.90114747
9copper ion transport (GO:0006825)6.62370125
10excretion (GO:0007588)6.45414298
11copper ion homeostasis (GO:0055070)6.07090404
12ethanol metabolic process (GO:0006067)6.05151079
13pattern specification involved in kidney development (GO:0061004)5.55992732
14left/right pattern formation (GO:0060972)5.37223603
15vitamin transmembrane transport (GO:0035461)5.27659248
16surfactant homeostasis (GO:0043129)5.19921613
17regulation of cilium movement (GO:0003352)5.05106448
18regulation of somitogenesis (GO:0014807)4.93723092
19terpenoid biosynthetic process (GO:0016114)4.89943101
20transepithelial transport (GO:0070633)4.88519360
21retinoic acid metabolic process (GO:0042573)4.65122786
22exogenous drug catabolic process (GO:0042738)4.53080137
23multicellular organismal water homeostasis (GO:0050891)4.51304233
24interferon-gamma secretion (GO:0072643)4.47125223
25hemidesmosome assembly (GO:0031581)4.46477975
26sodium ion homeostasis (GO:0055078)4.38096518
27left/right axis specification (GO:0070986)4.28755232
28one-carbon compound transport (GO:0019755)4.26493819
29drug catabolic process (GO:0042737)4.24458929
30chemical homeostasis within a tissue (GO:0048875)4.22291424
31microtubule bundle formation (GO:0001578)4.19063434
32negative regulation of T cell differentiation in thymus (GO:0033085)4.18078390
33renal absorption (GO:0070293)4.10060126
34response to copper ion (GO:0046688)4.07856556
35cilium organization (GO:0044782)4.04857262
36negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.03444933
37citrulline biosynthetic process (GO:0019240)4.01837705
38ventricular system development (GO:0021591)3.99223531
39intraciliary transport (GO:0042073)3.97835219
40COPI coating of Golgi vesicle (GO:0048205)3.94079885
41Golgi transport vesicle coating (GO:0048200)3.94079885
42cilium assembly (GO:0042384)3.93591371
43lung epithelium development (GO:0060428)3.93300959
44sperm capacitation (GO:0048240)3.85259751
45water homeostasis (GO:0030104)3.81440218
46retinol metabolic process (GO:0042572)3.81366718
47cellular zinc ion homeostasis (GO:0006882)3.74867052
48primary alcohol metabolic process (GO:0034308)3.74515905
49regulation of metalloenzyme activity (GO:0048552)3.68876766
50negative regulation of humoral immune response (GO:0002921)3.67566642
51flavonoid metabolic process (GO:0009812)3.63055303
52urate metabolic process (GO:0046415)3.61194716
53regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.60996174
54response to mercury ion (GO:0046689)3.55085375
55lactation (GO:0007595)3.54367144
56positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.50526877
57negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.49941290
58positive regulation of osteoblast proliferation (GO:0033690)3.48001981
59protein localization to cilium (GO:0061512)3.44887098
60bicarbonate transport (GO:0015701)3.42876884
61calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.40074794
62secretion by tissue (GO:0032941)3.37287652
63negative regulation of immunoglobulin mediated immune response (GO:0002890)3.34828935
64negative regulation of B cell mediated immunity (GO:0002713)3.34828935
65* O-glycan processing (GO:0016266)3.34542482
66intestinal epithelial cell development (GO:0060576)3.34219559
67sequestering of metal ion (GO:0051238)3.33496153
68lung lobe morphogenesis (GO:0060463)3.32813222
69antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.32094288
70antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32094288
71positive regulation of p38MAPK cascade (GO:1900745)3.27271249
72desmosome organization (GO:0002934)3.25416112
73bundle of His cell to Purkinje myocyte communication (GO:0086069)3.24004293
74glutathione derivative metabolic process (GO:1901685)3.23943872
75glutathione derivative biosynthetic process (GO:1901687)3.23943872
76regulation of microtubule-based movement (GO:0060632)3.23122695
774-hydroxyproline metabolic process (GO:0019471)3.21600402
78ectoderm development (GO:0007398)3.21378180
79glutathione biosynthetic process (GO:0006750)3.20091669
80regulation of interleukin-5 production (GO:0032674)3.17725647
81positive regulation of toll-like receptor signaling pathway (GO:0034123)3.17721562
82growth hormone receptor signaling pathway (GO:0060396)3.15628996
83ethanol oxidation (GO:0006069)3.14433048
84cellular component assembly involved in morphogenesis (GO:0010927)3.14412363
85centriole assembly (GO:0098534)3.13684555
86glomerular epithelial cell development (GO:0072310)3.13414827
87body fluid secretion (GO:0007589)3.12870751
88cilium morphogenesis (GO:0060271)3.11970436
89regulation of female gonad development (GO:2000194)3.10978543
90tolerance induction (GO:0002507)3.10102383
91type B pancreatic cell proliferation (GO:0044342)3.07594921
92sensory perception of taste (GO:0050909)3.07525514
93regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.02700915
94* protein O-linked glycosylation (GO:0006493)3.01809302
95cell projection assembly (GO:0030031)3.01330793
96regulation of apoptotic process involved in morphogenesis (GO:1902337)3.00265860
97nonribosomal peptide biosynthetic process (GO:0019184)2.99197715
98epoxygenase P450 pathway (GO:0019373)2.96810014
99phosphatidylcholine biosynthetic process (GO:0006656)2.96640522
100regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.95845358
101zinc ion homeostasis (GO:0055069)2.94098785
102phosphate ion homeostasis (GO:0055062)2.91954507
103trivalent inorganic anion homeostasis (GO:0072506)2.91954507
104tyrosine metabolic process (GO:0006570)2.91914094
105biotin metabolic process (GO:0006768)2.88480348
106iron ion import (GO:0097286)2.88231448
107hypotonic response (GO:0006971)2.85533881
108tryptophan metabolic process (GO:0006568)2.85425517
109pyrimidine-containing compound transmembrane transport (GO:0072531)2.83152712
110collecting duct development (GO:0072044)2.82111923
111monovalent inorganic cation homeostasis (GO:0055067)2.81711523
112regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.80254120
113hepatocyte apoptotic process (GO:0097284)2.79817928
114negative regulation of keratinocyte proliferation (GO:0010839)2.78649537
115hydrogen peroxide biosynthetic process (GO:0050665)2.77861990
116regulation of hippo signaling (GO:0035330)2.76677207
117drug metabolic process (GO:0017144)2.75931890
118transition metal ion transport (GO:0000041)2.74980787
119thyroid hormone metabolic process (GO:0042403)2.74883954
120phosphate ion transport (GO:0006817)2.73601181
121retinal metabolic process (GO:0042574)2.73149512
122water transport (GO:0006833)2.72279015
123pentose-phosphate shunt (GO:0006098)2.72196334
124response to xenobiotic stimulus (GO:0009410)2.71435359
125tight junction assembly (GO:0070830)2.70914911
126regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.70431469
127striated muscle atrophy (GO:0014891)2.69853683
128L-ascorbic acid metabolic process (GO:0019852)2.68583358
129keratinocyte differentiation (GO:0030216)2.68268582
130cellular glucuronidation (GO:0052695)2.68114886
131drug transmembrane transport (GO:0006855)2.67966265
132antigen processing and presentation of endogenous antigen (GO:0019883)2.67501649
133response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.66230055
134response to host (GO:0075136)2.66230055
135response to host defenses (GO:0052200)2.66230055
136cytoplasmic microtubule organization (GO:0031122)2.65376060
137regulation of interleukin-13 production (GO:0032656)2.65338006
138fucose catabolic process (GO:0019317)2.65249512
139L-fucose metabolic process (GO:0042354)2.65249512
140L-fucose catabolic process (GO:0042355)2.65249512
141lysine metabolic process (GO:0006553)2.64688743
142lysine catabolic process (GO:0006554)2.64688743
143daunorubicin metabolic process (GO:0044597)2.63927243
144polyketide metabolic process (GO:0030638)2.63927243
145doxorubicin metabolic process (GO:0044598)2.63927243
146cellular response to growth hormone stimulus (GO:0071378)2.63646745
147neurotransmitter biosynthetic process (GO:0042136)2.63499374
148metanephric tubule development (GO:0072170)2.63436056
149metanephric nephron tubule development (GO:0072234)2.63436056
150decidualization (GO:0046697)2.62782171
151regulation of germinal center formation (GO:0002634)2.62703930
152aminoglycoside antibiotic metabolic process (GO:0030647)2.62293835
153glucuronate metabolic process (GO:0019585)2.61561148
154uronic acid metabolic process (GO:0006063)2.61561148
155microtubule-based movement (GO:0007018)2.61208681
156keratinization (GO:0031424)2.60829247
157thyroid hormone generation (GO:0006590)2.60010338
158norepinephrine metabolic process (GO:0042415)2.59620990
159progesterone metabolic process (GO:0042448)2.58758408
160response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.58517577
161response to host immune response (GO:0052572)2.58517577
162establishment of apical/basal cell polarity (GO:0035089)2.57990859
163regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.57783128
164maintenance of gastrointestinal epithelium (GO:0030277)2.57072646
165alpha-linolenic acid metabolic process (GO:0036109)2.56725215
166photoreceptor cell maintenance (GO:0045494)2.56455155
167fucosylation (GO:0036065)2.56157696
168NADPH regeneration (GO:0006740)2.55864283
169polyol transport (GO:0015791)2.55494804
170regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.54628787
171reactive oxygen species biosynthetic process (GO:1903409)2.54266059
172oligosaccharide biosynthetic process (GO:0009312)2.53062194
173organic cation transport (GO:0015695)2.52882578
174mammary gland epithelial cell differentiation (GO:0060644)2.52828026
175metanephric nephron epithelium development (GO:0072243)2.51360913
176lung alveolus development (GO:0048286)2.51122403
177peptide biosynthetic process (GO:0043043)2.50540892
178phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.49874483
179phosphate ion transmembrane transport (GO:0035435)2.49616195
180skeletal muscle adaptation (GO:0043501)2.43718377
181carnitine metabolic process (GO:0009437)2.42608913
182ear development (GO:0043583)2.41528619
183androgen metabolic process (GO:0008209)2.41525790
184xenobiotic metabolic process (GO:0006805)2.40462840
185axonemal dynein complex assembly (GO:0070286)13.3732014
186cilium or flagellum-dependent cell motility (GO:0001539)11.5041494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.70035178
2ESR1_21235772_ChIP-Seq_MCF-7_Human4.29899115
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.93886410
4ESR2_21235772_ChIP-Seq_MCF-7_Human3.60041428
5STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse3.54782087
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.21407955
7CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.17126953
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.92829268
9DROSHA_22980978_ChIP-Seq_HELA_Human2.70022282
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.56038799
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.50489474
12FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.49424089
13FOXO3_23340844_ChIP-Seq_DLD1_Human2.41427079
14ESR1_15608294_ChIP-ChIP_MCF-7_Human2.35292092
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31243907
16* SOX2_20726797_ChIP-Seq_SW620_Human2.20764113
17SOX2_27498859_Chip-Seq_STOMACH_Mouse2.19753275
18PPAR_26484153_Chip-Seq_NCI-H1993_Human2.13902284
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13755409
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.10986833
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.08201482
22CLOCK_20551151_ChIP-Seq_293T_Human2.07137542
23ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.01480189
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.98450812
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.98014729
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88043125
27VDR_22108803_ChIP-Seq_LS180_Human1.86807437
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.76307729
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.73362565
30GATA4_25053715_ChIP-Seq_YYC3_Human1.72130551
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.71565876
32SOX9_24532713_ChIP-Seq_HFSC_Mouse1.70602224
33RXR_22158963_ChIP-Seq_LIVER_Mouse1.69965563
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65096814
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63981618
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57661758
37RUNX1_27514584_Chip-Seq_MCF-7_Human1.54392770
38LXR_22158963_ChIP-Seq_LIVER_Mouse1.53600851
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53165633
40RACK7_27058665_Chip-Seq_MCF-7_Human1.51685985
41AHR_22903824_ChIP-Seq_MCF-7_Human1.48657672
42* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.44811490
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43824485
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43294491
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42938965
46* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40981730
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40873368
48ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.40651273
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.40481657
50ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.39910204
51* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.39423234
52FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.39279848
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.38960600
54KLF5_25053715_ChIP-Seq_YYC3_Human1.38159239
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37924792
56CJUN_26792858_Chip-Seq_BT549_Human1.37273867
57ZNF263_19887448_ChIP-Seq_K562_Human1.36721977
58* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.36707401
59FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36564778
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36252530
61SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32797626
62SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32797626
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31615552
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29911198
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28789888
66* GATA6_25053715_ChIP-Seq_YYC3_Human1.27785123
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27651289
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24123203
69* GATA3_24758297_ChIP-Seq_MCF-7_Human1.24060156
70BCAT_22108803_ChIP-Seq_LS180_Human1.23906498
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21153191
72STAT1_20625510_ChIP-Seq_HELA_Human1.16366136
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.14625664
74ATF3_27146783_Chip-Seq_COLON_Human1.14448386
75FOXA2_19822575_ChIP-Seq_HepG2_Human1.11016088
76CEBPB_22108803_ChIP-Seq_LS180_Human1.09184688
77TBX20_22080862_ChIP-Seq_HEART_Mouse1.07852365
78TBX20_22328084_ChIP-Seq_HEART_Mouse1.07852365
79GBX2_23144817_ChIP-Seq_PC3_Human1.07301526
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.05544839
81* SMAD3_21741376_ChIP-Seq_HESCs_Human1.05537909
82TP63_23658742_ChIP-Seq_EP156T_Human1.04032808
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.03952342
84TP53_16413492_ChIP-PET_HCT116_Human1.02705047
85TCF4_22108803_ChIP-Seq_LS180_Human1.01726650
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01715133
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01145948
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00814484
89SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98698001
90FOXA1_25552417_ChIP-Seq_VCAP_Human0.97497091
91TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97180165
92ETV1_20927104_ChIP-Seq_GIST48_Human0.96983104
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96641489
94FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95404654
95EZH2_27294783_Chip-Seq_ESCs_Mouse0.95298792
96SMC4_20622854_ChIP-Seq_HELA_Human0.94516460
97* ER_23166858_ChIP-Seq_MCF-7_Human0.94511639
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94380931
99CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93902666
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92550188
101STAT3_23295773_ChIP-Seq_U87_Human0.92385689
102RAD21_21589869_ChIP-Seq_MESCs_Mouse0.92066819
103SMRT_27268052_Chip-Seq_Bcells_Human0.91999760
104CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91886310
105SMAD4_21799915_ChIP-Seq_A2780_Human0.91575549
106CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91123659
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90410906
108FOXA1_25329375_ChIP-Seq_VCAP_Human0.90139693
109FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90139693
110ZNF274_21170338_ChIP-Seq_K562_Hela0.89592171
111EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88711681
112AR_21572438_ChIP-Seq_LNCaP_Human0.88017417
113NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87834138
114IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87621608
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86709277
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86491608
117CTCF_27219007_Chip-Seq_Bcells_Human0.85774916
118PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.85625881
119FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.85618640
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85525775
121* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85449862
122CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85411758
123HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85262960
124PHF8_20622853_ChIP-Seq_HELA_Human0.84956099
125CDX2_22108803_ChIP-Seq_LS180_Human0.84757397
126CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.84714636
127AR_20517297_ChIP-Seq_VCAP_Human0.83951223
128* TCF4_23295773_ChIP-Seq_U87_Human0.83945574
129NCOR_22424771_ChIP-Seq_293T_Human0.83936843
130RBPJ_21746931_ChIP-Seq_IB4_Human0.83069411
131GATA2_19941826_ChIP-Seq_K562_Human0.82949463
132RXR_22108803_ChIP-Seq_LS180_Human0.82794360
133* SMAD4_21741376_ChIP-Seq_HESCs_Human0.82643053
134HNFA_21074721_ChIP-Seq_CACO-2_Human0.82463757
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82206174
136UBF1/2_26484160_Chip-Seq_HMECs_Human0.82082468
137ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.78024933
138TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76821954
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76449594
140VDR_24787735_ChIP-Seq_THP-1_Human0.75680518
141TP53_18474530_ChIP-ChIP_U2OS_Human0.73378761
142TP63_22573176_ChIP-Seq_HFKS_Human0.72824848
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.71461596
144BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71404255
145ERG_20517297_ChIP-Seq_VCAP_Human0.70977988
146* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70910878
147POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.69578330
148P300_27058665_Chip-Seq_ZR-75-30cells_Human0.69323396
149TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.68340321
150STAT6_21828071_ChIP-Seq_BEAS2B_Human0.67849059
151STAT3_1855785_ChIP-Seq_MESCs_Mouse0.67783403

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.76083403
2MP0003300_gastrointestinal_ulcer4.61739222
3MP0004885_abnormal_endolymph4.51507304
4MP0001881_abnormal_mammary_gland4.35823240
5MP0002653_abnormal_ependyma_morphology2.96908407
6MP0001756_abnormal_urination2.86519561
7MP0004043_abnormal_pH_regulation2.72624907
8MP0002132_abnormal_respiratory_system2.65049388
9MP0005365_abnormal_bile_salt2.63328803
10MP0002876_abnormal_thyroid_physiology2.62030984
11MP0002163_abnormal_gland_morphology2.61910365
12MP0005408_hypopigmentation2.58293451
13MP0001765_abnormal_ion_homeostasis2.51580221
14MP0004264_abnormal_extraembryonic_tissu2.48714914
15MP0009780_abnormal_chondrocyte_physiolo2.48663365
16MP0002098_abnormal_vibrissa_morphology2.44628546
17MP0009643_abnormal_urine_homeostasis2.39811835
18MP0001984_abnormal_olfaction2.37851926
19MP0004019_abnormal_vitamin_homeostasis2.37508367
20MP0002168_other_aberrant_phenotype2.27107952
21MP0005636_abnormal_mineral_homeostasis2.25917230
22MP0002277_abnormal_respiratory_mucosa2.21328860
23MP0005395_other_phenotype2.19497197
24MP0004782_abnormal_surfactant_physiolog2.09793805
25MP0004133_heterotaxia2.07502112
26MP0003718_maternal_effect2.07040165
27MP0001177_atelectasis2.06305648
28MP0002138_abnormal_hepatobiliary_system2.05910194
29MP0000462_abnormal_digestive_system2.01743796
30MP0003195_calcinosis2.00568507
31MP0005083_abnormal_biliary_tract1.98180795
32MP0005171_absent_coat_pigmentation1.91724298
33MP0005275_abnormal_skin_tensile1.91579146
34MP0002136_abnormal_kidney_physiology1.79706428
35MP0010678_abnormal_skin_adnexa1.73895019
36MP0001958_emphysema1.68548875
37MP0002254_reproductive_system_inflammat1.67942076
38MP0000627_abnormal_mammary_gland1.67834242
39MP0003252_abnormal_bile_duct1.66273965
40MP0001485_abnormal_pinna_reflex1.65287018
41MP0008438_abnormal_cutaneous_collagen1.64598865
42MP0004742_abnormal_vestibular_system1.59803074
43MP0005220_abnormal_exocrine_pancreas1.58886236
44MP0002796_impaired_skin_barrier1.55369825
45MP0010155_abnormal_intestine_physiology1.54692864
46MP0004272_abnormal_basement_membrane1.51782187
47MP0003878_abnormal_ear_physiology1.51317629
48MP0005377_hearing/vestibular/ear_phenot1.51317629
49MP0003566_abnormal_cell_adhesion1.50898618
50MP0005360_urolithiasis1.48890680
51MP0008789_abnormal_olfactory_epithelium1.39839785
52MP0005379_endocrine/exocrine_gland_phen1.38930879
53MP0002909_abnormal_adrenal_gland1.38020394
54MP0002295_abnormal_pulmonary_circulatio1.37714620
55MP0002133_abnormal_respiratory_system1.37597881
56MP0005388_respiratory_system_phenotype1.37597881
57MP0003329_amyloid_beta_deposits1.30079916
58MP0003806_abnormal_nucleotide_metabolis1.29743968
59MP0005670_abnormal_white_adipose1.29255481
60MP0000613_abnormal_salivary_gland1.29025066
61MP0005332_abnormal_amino_acid1.27795262
62MP0001664_abnormal_digestion1.27499146
63MP0002139_abnormal_hepatobiliary_system1.25418880
64MP0003183_abnormal_peptide_metabolism1.22129671
65MP0001849_ear_inflammation1.19859657
66MP0000371_diluted_coat_color1.17431257
67MP0000465_gastrointestinal_hemorrhage1.17425240
68MP0001873_stomach_inflammation1.13518561
69MP0003879_abnormal_hair_cell1.13110248
70MP0002089_abnormal_postnatal_growth/wei1.11496549
71MP0003283_abnormal_digestive_organ1.10018148
72MP0008872_abnormal_physiological_respon1.09067678
73MP0003045_fibrosis1.06697421
74MP0000372_irregular_coat_pigmentation1.06487016
75MP0010329_abnormal_lipoprotein_level1.05711417
76MP0010386_abnormal_urinary_bladder1.04539355
77MP0005551_abnormal_eye_electrophysiolog1.03731347
78MP0003866_abnormal_defecation1.03625678
79MP0001666_abnormal_nutrient_absorption1.02222345
80MP0008875_abnormal_xenobiotic_pharmacok1.00716757
81MP0003453_abnormal_keratinocyte_physiol0.98442603
82MP0002060_abnormal_skin_morphology0.97269640
83MP0006054_spinal_hemorrhage0.93287058
84MP0001663_abnormal_digestive_system0.93140012
85MP0005085_abnormal_gallbladder_physiolo0.89312263
86MP0002160_abnormal_reproductive_system0.87688064
87MP0005023_abnormal_wound_healing0.86248971
88MP0005501_abnormal_skin_physiology0.85563759
89MP0002735_abnormal_chemical_nociception0.84892275
90MP0001270_distended_abdomen0.84203148
91MP0001502_abnormal_circadian_rhythm0.83987893
92MP0002877_abnormal_melanocyte_morpholog0.81596489
93MP0003186_abnormal_redox_activity0.81357326
94MP0000470_abnormal_stomach_morphology0.81142007
95MP0005375_adipose_tissue_phenotype0.80565847
96MP0005381_digestive/alimentary_phenotyp0.79334454
97MP0000427_abnormal_hair_cycle0.79327188
98MP0003705_abnormal_hypodermis_morpholog0.78708805
99MP0005248_abnormal_Harderian_gland0.78472766
100MP0000467_abnormal_esophagus_morphology0.77895638
101MP0008004_abnormal_stomach_pH0.77704044
102MP0001501_abnormal_sleep_pattern0.77140573
103MP0005666_abnormal_adipose_tissue0.76811805
104MP0005503_abnormal_tendon_morphology0.75876612
105MP0001216_abnormal_epidermal_layer0.75681837
106MP0005319_abnormal_enzyme/_coenzyme0.74282571
107MP0002282_abnormal_trachea_morphology0.73113266
108MP0000477_abnormal_intestine_morphology0.72683923
109MP0000377_abnormal_hair_follicle0.72638516
110MP0000538_abnormal_urinary_bladder0.72286144
111MP0003953_abnormal_hormone_level0.71690590
112MP0010368_abnormal_lymphatic_system0.70889652
113MP0000026_abnormal_inner_ear0.70645200
114MP0000003_abnormal_adipose_tissue0.70608559
115MP0002234_abnormal_pharynx_morphology0.69689831
116MP0000383_abnormal_hair_follicle0.67518337
117MP0005499_abnormal_olfactory_system0.67497519
118MP0005394_taste/olfaction_phenotype0.67497519
119MP0001970_abnormal_pain_threshold0.67371356
120MP0002249_abnormal_larynx_morphology0.66076553
121MP0005164_abnormal_response_to0.66030685
122MP0000762_abnormal_tongue_morphology0.65888450
123MP0000230_abnormal_systemic_arterial0.64906930
124MP0000537_abnormal_urethra_morphology0.63679018
125MP0003638_abnormal_response/metabolism_0.63536334
126MP0002928_abnormal_bile_duct0.62655457
127MP0000566_synostosis0.62651260
128MP0002734_abnormal_mechanical_nocicepti0.61143078
129MP0002135_abnormal_kidney_morphology0.61012554
130MP0002229_neurodegeneration0.60435589
131MP0004147_increased_porphyrin_level0.60116261
132MP0001175_abnormal_lung_morphology0.59768407
133MP0003303_peritoneal_inflammation0.59697664
134MP0000678_abnormal_parathyroid_gland0.59130183
135MP0002233_abnormal_nose_morphology0.58652030
136MP0000681_abnormal_thyroid_gland0.58419511
137MP0005646_abnormal_pituitary_gland0.57678399
138MP0002933_joint_inflammation0.57281425
139MP0002118_abnormal_lipid_homeostasis0.57264734
140MP0008961_abnormal_basal_metabolism0.57131896
141MP0005584_abnormal_enzyme/coenzyme_acti0.57030674
142MP0000604_amyloidosis0.56972924
143MP0001944_abnormal_pancreas_morphology0.56148016
144MP0002896_abnormal_bone_mineralization0.55702271
145MP0005448_abnormal_energy_balance0.55564285
146MP0000631_abnormal_neuroendocrine_gland0.55334224
147MP0003448_altered_tumor_morphology0.55203406
148MP0010771_integument_phenotype0.55094445
149MP0005310_abnormal_salivary_gland0.54686328
150MP0001851_eye_inflammation0.54449403
151MP0005165_increased_susceptibility_to0.53483205
152MP0010352_gastrointestinal_tract_polyps0.52712734
153MP0003656_abnormal_erythrocyte_physiolo0.52711486

Predicted human phenotypes

RankGene SetZ-score
1Hypokalemic alkalosis (HP:0001949)9.99467721
2Hyperactive renin-angiotensin system (HP:0000841)9.75830474
3Abnormal respiratory epithelium morphology (HP:0012253)9.26647388
4Abnormal respiratory motile cilium morphology (HP:0005938)9.26647388
5Abnormality of chloride homeostasis (HP:0011422)9.14599552
6Dynein arm defect of respiratory motile cilia (HP:0012255)9.11580791
7Absent/shortened dynein arms (HP:0200106)9.11580791
8Abnormal respiratory motile cilium physiology (HP:0012261)9.09343512
9Renal salt wasting (HP:0000127)9.00673094
10Abnormal ciliary motility (HP:0012262)8.93347391
11Rhinitis (HP:0012384)8.54897845
12Abnormality of cochlea (HP:0000375)8.18699520
13Hyperaldosteronism (HP:0000859)7.84816121
14Metabolic alkalosis (HP:0200114)6.92658033
15Chronic bronchitis (HP:0004469)6.11950898
16Morphological abnormality of the inner ear (HP:0011390)6.00141029
17Nasal polyposis (HP:0100582)5.55048857
18Decreased circulating renin level (HP:0003351)5.43996539
19Alkalosis (HP:0001948)5.39088905
20Hyponatremia (HP:0002902)5.15548353
21Abnormality of renal excretion (HP:0011036)4.95481199
22Abnormality of renin-angiotensin system (HP:0000847)4.92655533
23Hyperkalemia (HP:0002153)4.77191627
24Hypokalemia (HP:0002900)4.70124756
25Polyuria (HP:0000103)4.69010546
26Abnormality of sodium homeostasis (HP:0010931)4.68675649
27Gout (HP:0001997)4.56401608
28Abnormal urine output (HP:0012590)4.39191161
29Male infertility (HP:0003251)4.24043061
30Ileus (HP:0002595)4.01958946
31Tubulointerstitial fibrosis (HP:0005576)3.97031698
32Abnormality of potassium homeostasis (HP:0011042)3.96524491
33Adrenal overactivity (HP:0002717)3.87726925
34Recurrent sinusitis (HP:0011108)3.76478108
35Rectal prolapse (HP:0002035)3.75703593
36Infertility (HP:0000789)3.69539111
37Abnormality of the right ventricle (HP:0001707)3.50710471
38Dehydration (HP:0001944)3.40481144
39Chronic sinusitis (HP:0011109)3.38038909
40Hypotension (HP:0002615)3.34982023
41True hermaphroditism (HP:0010459)3.32985134
42Arterial tortuosity (HP:0005116)3.31836637
43Vascular calcification (HP:0004934)3.22048675
44Increased circulating renin level (HP:0000848)3.16514127
45Hypercalciuria (HP:0002150)3.15738654
46Pancreatic fibrosis (HP:0100732)3.15468832
47Cystic liver disease (HP:0006706)3.08363494
48Recurrent otitis media (HP:0000403)3.05486645
49Pancreatic cysts (HP:0001737)3.03333562
50Vascular tortuosity (HP:0004948)2.95479950
51Tetany (HP:0001281)2.94226331
52Onycholysis (HP:0001806)2.92581827
53Cardiovascular calcification (HP:0011915)2.92180146
54Hypomagnesemia (HP:0002917)2.85955726
55Occipital encephalocele (HP:0002085)2.84906184
56Abnormality of purine metabolism (HP:0004352)2.83324327
57Abnormality of midbrain morphology (HP:0002418)2.79680690
58Molar tooth sign on MRI (HP:0002419)2.79680690
59Nephronophthisis (HP:0000090)2.73223627
60Conjugated hyperbilirubinemia (HP:0002908)2.62388153
61Hyperuricemia (HP:0002149)2.58589060
62Increased purine levels (HP:0004368)2.58589060
63Chronic hepatic failure (HP:0100626)2.54380574
64Chronic otitis media (HP:0000389)2.51310512
65Chondrocalcinosis (HP:0000934)2.45594460
66Spinal muscular atrophy (HP:0007269)2.42326829
67Right ventricular cardiomyopathy (HP:0011663)2.42091095
68Abnormality of magnesium homeostasis (HP:0004921)2.40488645
69Renal tubular acidosis (HP:0001947)2.37002939
70Esophageal varix (HP:0002040)2.34929009
71Glomerulosclerosis (HP:0000096)2.33660890
72Tubulointerstitial abnormality (HP:0001969)2.33418843
73Abnormality of Sharpey fibers (HP:0100685)2.33083062
74Osteomalacia (HP:0002749)2.32429748
75Atelectasis (HP:0100750)2.30058519
76Hyperparathyroidism (HP:0000843)2.29131264
77Bronchiectasis (HP:0002110)2.27548623
78Hypothermia (HP:0002045)2.25227304
79Interstitial pulmonary disease (HP:0006530)2.24149862
80Milia (HP:0001056)2.21645666
81Bronchitis (HP:0012387)2.21180796
82Pustule (HP:0200039)2.19789818
83Abnormality of the renal cortex (HP:0011035)2.16332841
84Abnormality of monocarboxylic acid metabolism (HP:0010996)2.14985233
85Polydipsia (HP:0001959)2.09511422
86Abnormal drinking behavior (HP:0030082)2.09511422
87Congenital hepatic fibrosis (HP:0002612)2.07032594
88Pili torti (HP:0003777)2.04830107
89Tubular atrophy (HP:0000092)2.03120058
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.4042927
91Goiter (HP:0000853)1.99027099
92Postaxial foot polydactyly (HP:0001830)1.93190906
93Nephrocalcinosis (HP:0000121)1.92429295
94Renal tubular dysfunction (HP:0000124)1.92317336
95Tubulointerstitial nephritis (HP:0001970)1.92111205
96Male pseudohermaphroditism (HP:0000037)1.90092451
97Exocrine pancreatic insufficiency (HP:0001738)1.87600177
98Ureteral obstruction (HP:0006000)1.84469452
99Spontaneous hematomas (HP:0007420)1.84332996
100Medial flaring of the eyebrow (HP:0010747)1.84025054
101Hyperphosphaturia (HP:0003109)1.83667437
102Atrophic scars (HP:0001075)1.78031748
103Azoospermia (HP:0000027)1.77922576
104Abnormality of nucleobase metabolism (HP:0010932)1.77122826
105Abnormality of renal resorption (HP:0011038)1.77046108
106Furrowed tongue (HP:0000221)1.75939184
107Congenital sensorineural hearing impairment (HP:0008527)1.75843965
108Glycosuria (HP:0003076)1.69937056
109Abnormality of urine glucose concentration (HP:0011016)1.69937056
110Aplasia/Hypoplasia of the tongue (HP:0010295)1.69605966
111Bell-shaped thorax (HP:0001591)1.66592845
112Nephrolithiasis (HP:0000787)1.65434887
113Popliteal pterygium (HP:0009756)1.63925337
114Decreased central vision (HP:0007663)1.63391280
115Broad ribs (HP:0000885)1.62778459
116Nephropathy (HP:0000112)1.61242255
117Stage 5 chronic kidney disease (HP:0003774)1.60880870
118Abnormal urine phosphate concentration (HP:0012599)1.60086566
119Metabolic acidosis (HP:0001942)1.60086435
120Anencephaly (HP:0002323)1.59464358
121Woolly hair (HP:0002224)1.57621618
122Fragile nails (HP:0001808)1.57597193
123Abnormality of the renal medulla (HP:0100957)1.56469530
124Congenital primary aphakia (HP:0007707)1.56388101
125Gait imbalance (HP:0002141)1.55215649
126Curly hair (HP:0002212)1.54356524
127Tracheal stenosis (HP:0002777)1.54112997
128Lip pit (HP:0100267)1.52536269
129Hypoplasia of dental enamel (HP:0006297)1.51294169
130Exostoses (HP:0100777)1.50956400
131Absent rod-and cone-mediated responses on ERG (HP:0007688)1.49619471
132Sclerocornea (HP:0000647)1.49245865
133Aplasia/Hypoplasia of the spleen (HP:0010451)1.48590469
134Ventricular fibrillation (HP:0001663)1.47030483
135Cone-rod dystrophy (HP:0000548)1.45527232
136Flat acetabular roof (HP:0003180)1.45331958
137Vertigo (HP:0002321)1.45084229
138Malnutrition (HP:0004395)1.44273578
139Nephrogenic diabetes insipidus (HP:0009806)1.43240545
140Absent speech (HP:0001344)1.42807243
141Tinnitus (HP:0000360)1.42514304
142Intrahepatic cholestasis (HP:0001406)1.41116266
143Recurrent bronchitis (HP:0002837)1.38617569
144Vacuolated lymphocytes (HP:0001922)1.37064477
145Fat malabsorption (HP:0002630)1.35678503
146Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.35366134
147Potter facies (HP:0002009)1.35224894
148Facial shape deformation (HP:0011334)1.35224894
149Abnormality of macular pigmentation (HP:0008002)1.34455920
150Asplenia (HP:0001746)1.33728282
151Abnormal rod and cone electroretinograms (HP:0008323)1.33606737
152Oculomotor apraxia (HP:0000657)1.32457138
153Hypoplastic labia majora (HP:0000059)1.29873065
154Retinitis pigmentosa (HP:0000510)1.29727148
155Syncope (HP:0001279)1.28870165
156Postaxial hand polydactyly (HP:0001162)1.28208708
157Hypoplasia of the uterus (HP:0000013)1.27773036
158Taurodontia (HP:0000679)1.27094733
159Thin bony cortex (HP:0002753)1.26764304
160Hyperphosphatemia (HP:0002905)1.25819377
161Amelogenesis imperfecta (HP:0000705)1.25192588
162Aneurysm (HP:0002617)1.21744035
163Abnormality of the nasal mucosa (HP:0000433)1.21085105

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.06841918
2WNK33.71881970
3WNK43.15505020
4PRKG22.62463836
5FRK2.51961560
6OXSR12.41011693
7LATS12.36285264
8SIK12.05810026
9LMTK210.6888809
10STK38L1.99078698
11NME11.97236354
12MAP3K31.86133348
13STK391.83799702
14ERN11.79061318
15ACVR1B1.68534435
16MAP3K21.64824945
17MAP2K61.62870336
18MST41.53742311
19TAOK11.53667746
20TLK11.52620732
21TRIB31.46509220
22STK101.35793899
23MST1R1.34627013
24EPHB11.32827221
25FER1.32376776
26LRRK21.28963109
27PTK21.22596072
28GRK11.19411942
29PKN21.18692735
30PTK61.17982197
31INSRR1.14473807
32MAPK151.08713993
33EEF2K1.08327969
34CASK1.07548931
35CAMK1D1.04405499
36ZAP701.00668751
37MAP4K20.96146136
38TGFBR20.95770807
39ADRBK20.94394186
40PDK20.94002360
41RIPK10.93105380
42PINK10.91405844
43MAPKAPK30.88092357
44EPHA30.87268615
45CAMK1G0.86679758
46MARK20.85539407
47RPS6KB20.85499488
48PDGFRB0.85305167
49TRPM70.85152737
50PAK40.84372634
51STK380.82333976
52PTK2B0.81348565
53PRKAA10.78438721
54EPHB20.77898864
55LATS20.70479713
56SGK4940.67664536
57SGK2230.67664536
58ERBB30.67541050
59MET0.67090264
60PDK40.66904428
61PDK30.66904428
62ROCK10.64259640
63DAPK20.63712728
64IRAK10.62488187
65SMG10.61247677
66STK30.60665964
67TAOK30.60429810
68MAPK130.59901975
69CSK0.59816108
70NEK60.58277811
71TBK10.56723304
72ADRBK10.56607015
73NUAK10.54575618
74BMPR1B0.53648023
75MAP3K10.52985336
76PRKCQ0.52904518
77GRK60.51572576
78SGK30.51488588
79BCR0.49964683
80MATK0.46855237
81CDC42BPA0.46841253
82ERBB20.46198898
83WNK10.45905558
84FGFR40.45834007
85BMX0.44182582
86SGK20.44172794
87TNK20.42708235
88PIK3CA0.42565014
89TRIM280.41909621
90TIE10.41863497
91PRKAA20.41556914
92PDPK10.40783981
93MAP2K10.40505856
94PRKD20.40032241
95PHKG10.39913061
96PHKG20.39913061
97HIPK20.37908615
98BCKDK0.37849864
99MAP2K20.37012916
100CDK60.36996202
101FGFR30.36907474
102MAP3K80.36617382
103PRKCA0.36498005
104MAP3K120.36217264
105MAP3K70.35923972
106FGFR20.35712099
107NTRK30.35264323
108PRKCZ0.35254493
109RET0.35222274
110PRKCD0.34893699
111MAP3K110.34469415
112SGK10.34122671
113ERBB40.33206615
114KSR20.32576514
115MUSK0.31603075
116GSK3A0.30202235
117TESK10.29756481
118CAMKK20.29723305
119PDGFRA0.29092058
120PAK30.29079942
121CSNK1A10.28626296
122STK240.28342246
123TAOK20.26414904
124IGF1R0.25817843
125PRKACA0.25806676
126CAMKK10.25631169
127PRKCI0.25485513
128NLK0.25234842
129PDK10.24704021
130DMPK0.24641555
131NEK20.24211706
132MAP2K30.23284345
133MAP3K90.23107988
134CHUK0.22175205
135MELK0.22138174
136ICK0.21488242
137TTK0.20396674
138ROCK20.20247814
139MYLK0.19597981
140TYK20.18020571
141PRKD10.17757866
142PRKCE0.16332141
143CDK90.15955935
144ABL10.14985454
145JAK10.14817889
146MTOR0.14321991
147JAK20.13434740

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.96339375
2Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.78399970
3Fatty acid biosynthesis_Homo sapiens_hsa000613.73271274
4Mineral absorption_Homo sapiens_hsa049783.26603017
5Vibrio cholerae infection_Homo sapiens_hsa051102.60879591
6Retinol metabolism_Homo sapiens_hsa008302.60635559
7Steroid hormone biosynthesis_Homo sapiens_hsa001402.35641526
8Linoleic acid metabolism_Homo sapiens_hsa005912.17400505
9Collecting duct acid secretion_Homo sapiens_hsa049662.15543656
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.10476806
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.00561295
12Propanoate metabolism_Homo sapiens_hsa006401.97294765
13Fatty acid degradation_Homo sapiens_hsa000711.76721547
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74073088
15Nitrogen metabolism_Homo sapiens_hsa009101.61391062
16Pyruvate metabolism_Homo sapiens_hsa006201.59907504
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58600364
18Fatty acid metabolism_Homo sapiens_hsa012121.55266789
19Adherens junction_Homo sapiens_hsa045201.45207626
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44230222
21Bile secretion_Homo sapiens_hsa049761.42508867
22Sulfur metabolism_Homo sapiens_hsa009201.41359880
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39466072
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.36930495
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.31690473
26ECM-receptor interaction_Homo sapiens_hsa045121.30452404
27Other glycan degradation_Homo sapiens_hsa005111.29633354
28Gastric acid secretion_Homo sapiens_hsa049711.25998698
29Taste transduction_Homo sapiens_hsa047421.24988812
30Tight junction_Homo sapiens_hsa045301.22681948
31Glycerolipid metabolism_Homo sapiens_hsa005611.19920719
32Peroxisome_Homo sapiens_hsa041461.16234589
33Glutathione metabolism_Homo sapiens_hsa004801.14353568
34Starch and sucrose metabolism_Homo sapiens_hsa005001.14277669
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14233549
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.12639157
37ABC transporters_Homo sapiens_hsa020101.12515309
38Prolactin signaling pathway_Homo sapiens_hsa049171.10372663
39Galactose metabolism_Homo sapiens_hsa000521.10332263
40Sphingolipid metabolism_Homo sapiens_hsa006001.10310064
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.09777051
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07803037
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06717796
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06694380
45Lysosome_Homo sapiens_hsa041420.99741056
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98994067
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98246096
48PPAR signaling pathway_Homo sapiens_hsa033200.98003542
49Focal adhesion_Homo sapiens_hsa045100.97168343
50Amoebiasis_Homo sapiens_hsa051460.97059840
51Small cell lung cancer_Homo sapiens_hsa052220.97046204
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96117155
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95549943
54Fat digestion and absorption_Homo sapiens_hsa049750.95154421
55Chemical carcinogenesis_Homo sapiens_hsa052040.93122428
56Pancreatic cancer_Homo sapiens_hsa052120.93090604
57beta-Alanine metabolism_Homo sapiens_hsa004100.87788056
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87617335
59Ether lipid metabolism_Homo sapiens_hsa005650.84509121
60Arginine biosynthesis_Homo sapiens_hsa002200.84020300
61Toxoplasmosis_Homo sapiens_hsa051450.83424525
62Rheumatoid arthritis_Homo sapiens_hsa053230.82612462
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82136999
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82020600
65Thyroid hormone synthesis_Homo sapiens_hsa049180.81594824
66Tryptophan metabolism_Homo sapiens_hsa003800.80966518
67Pancreatic secretion_Homo sapiens_hsa049720.80699888
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80596932
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79418544
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.79391060
71Hippo signaling pathway_Homo sapiens_hsa043900.78216674
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73343520
73Phototransduction_Homo sapiens_hsa047440.73107621
74Bladder cancer_Homo sapiens_hsa052190.72306947
75Ovarian steroidogenesis_Homo sapiens_hsa049130.70783606
76Endometrial cancer_Homo sapiens_hsa052130.70646135
77Vitamin digestion and absorption_Homo sapiens_hsa049770.70540956
78Proteoglycans in cancer_Homo sapiens_hsa052050.69932767
79Protein digestion and absorption_Homo sapiens_hsa049740.69682507
80Insulin resistance_Homo sapiens_hsa049310.67740378
81Histidine metabolism_Homo sapiens_hsa003400.66568413
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65524455
83Butanoate metabolism_Homo sapiens_hsa006500.65110901
84Hepatitis C_Homo sapiens_hsa051600.64765416
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63030521
86Complement and coagulation cascades_Homo sapiens_hsa046100.60193587
87Huntingtons disease_Homo sapiens_hsa050160.59590522
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59570676
89AMPK signaling pathway_Homo sapiens_hsa041520.59072494
90Arginine and proline metabolism_Homo sapiens_hsa003300.58777212
91Salivary secretion_Homo sapiens_hsa049700.58697394
92Carbon metabolism_Homo sapiens_hsa012000.58087140
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57957568
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56001983
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55055720
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54920112
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54534869
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53223987
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50512929
100Circadian rhythm_Homo sapiens_hsa047100.50116702
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.45900961
102Pentose phosphate pathway_Homo sapiens_hsa000300.45846350
103Dorso-ventral axis formation_Homo sapiens_hsa043200.45244356
104Thyroid cancer_Homo sapiens_hsa052160.44128780
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43653076
106Fatty acid elongation_Homo sapiens_hsa000620.43374221
107Renin secretion_Homo sapiens_hsa049240.42965135
108mTOR signaling pathway_Homo sapiens_hsa041500.42417623
109Chronic myeloid leukemia_Homo sapiens_hsa052200.42309857
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.41234412
111Renal cell carcinoma_Homo sapiens_hsa052110.40741342
112Tyrosine metabolism_Homo sapiens_hsa003500.40203068
113Nicotine addiction_Homo sapiens_hsa050330.39009551
114Phagosome_Homo sapiens_hsa041450.38299751
115Phenylalanine metabolism_Homo sapiens_hsa003600.37225724
116Choline metabolism in cancer_Homo sapiens_hsa052310.37136866
117Metabolic pathways_Homo sapiens_hsa011000.36989841
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36469231
119Renin-angiotensin system_Homo sapiens_hsa046140.34429173
120Arachidonic acid metabolism_Homo sapiens_hsa005900.33602362
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33345748
122Folate biosynthesis_Homo sapiens_hsa007900.32588386
123Serotonergic synapse_Homo sapiens_hsa047260.32478732
124Olfactory transduction_Homo sapiens_hsa047400.32439671
125Influenza A_Homo sapiens_hsa051640.32165580
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31902714
127Cocaine addiction_Homo sapiens_hsa050300.31893276
128Pathways in cancer_Homo sapiens_hsa052000.31302502
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.30699348
130FoxO signaling pathway_Homo sapiens_hsa040680.30505453
131Insulin secretion_Homo sapiens_hsa049110.29763526
132Salmonella infection_Homo sapiens_hsa051320.29251878
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29180136
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28628825
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23992265
136Fructose and mannose metabolism_Homo sapiens_hsa000510.22789648
137Notch signaling pathway_Homo sapiens_hsa043300.21755561
138Calcium signaling pathway_Homo sapiens_hsa040200.20517983
139Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19235632
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.15957165
141Axon guidance_Homo sapiens_hsa043600.15446758
142cAMP signaling pathway_Homo sapiens_hsa040240.15315475
143Asthma_Homo sapiens_hsa053100.09749751

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »