ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cilium or flagellum-dependent cell motility (GO:0001539)	8.29756829
2	motile cilium assembly (GO:0044458)	6.89361309
3	cilium movement (GO:0003341)	6.53392702
4	exogenous drug catabolic process (GO:0042738)	6.52972266
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.46439319
6	primary alcohol catabolic process (GO:0034310)	6.15099132
7	drug catabolic process (GO:0042737)	5.65230094
8	ethanol metabolic process (GO:0006067)	5.58329609
9	epithelial cilium movement (GO:0003351)	5.38044770
10	ethanol oxidation (GO:0006069)	5.23027869
11	epoxygenase P450 pathway (GO:0019373)	4.50181790
12	O-glycan processing (GO:0016266)	4.19550366
13	vitamin transmembrane transport (GO:0035461)	4.06715314
14	desmosome organization (GO:0002934)	4.01767828
15	cellular glucuronidation (GO:0052695)	3.96079931
16	multicellular organismal water homeostasis (GO:0050891)	3.79719580
17	axoneme assembly (GO:0035082)	3.76936679
18	diterpenoid biosynthetic process (GO:0016102)	3.74460624
19	left/right pattern formation (GO:0060972)	3.73655988
20	phenylpropanoid metabolic process (GO:0009698)	3.69079222
21	glucuronate metabolic process (GO:0019585)	3.65822758
22	uronic acid metabolic process (GO:0006063)	3.65822758
23	lung epithelium development (GO:0060428)	3.62196417
24	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.55115329
25	skeletal muscle adaptation (GO:0043501)	3.53985055
26	drug metabolic process (GO:0017144)	3.53760768
27	maintenance of gastrointestinal epithelium (GO:0030277)	3.48414303
28	daunorubicin metabolic process (GO:0044597)	3.42307978
29	polyketide metabolic process (GO:0030638)	3.42307978
30	doxorubicin metabolic process (GO:0044598)	3.42307978
31	water homeostasis (GO:0030104)	3.35333896
32	embryonic retina morphogenesis in camera-type eye (GO:0060059)	3.34929652
33	regulation of cilium movement (GO:0003352)	3.32875525
34	regulation of cholesterol homeostasis (GO:2000188)	3.32570679
35	glomerular epithelial cell development (GO:0072310)	3.32314958
36	striated muscle atrophy (GO:0014891)	3.29412639
37	bile acid biosynthetic process (GO:0006699)	3.24588583
38	macroautophagy (GO:0016236)	3.22115323
39	primary alcohol metabolic process (GO:0034308)	3.21296581
40	sperm capacitation (GO:0048240)	3.20147365
41	urea metabolic process (GO:0019627)	3.16400834
42	flavonoid metabolic process (GO:0009812)	3.09966568
43	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	3.08532964
44	negative regulation of myotube differentiation (GO:0010832)	3.08163967
45	bile acid metabolic process (GO:0008206)	3.06944606
46	skeletal muscle contraction (GO:0003009)	3.03987229
47	negative regulation of humoral immune response (GO:0002921)	3.03130011
48	glial cell proliferation (GO:0014009)	3.00539942
49	aminoglycoside antibiotic metabolic process (GO:0030647)	2.97169136
50	one-carbon compound transport (GO:0019755)	2.96222473
51	nitrogen cycle metabolic process (GO:0071941)	2.95207457
52	sodium ion homeostasis (GO:0055078)	2.88286052
53	protein O-linked glycosylation (GO:0006493)	2.87760862
54	epithelial structure maintenance (GO:0010669)	2.84770306
55	muscle organ morphogenesis (GO:0048644)	2.84305405
56	regulation of fibrinolysis (GO:0051917)	2.84039201
57	intestinal epithelial cell development (GO:0060576)	2.83690869
58	omega-hydroxylase P450 pathway (GO:0097267)	2.81463545
59	negative regulation of B cell mediated immunity (GO:0002713)	2.80269773
60	negative regulation of immunoglobulin mediated immune response (GO:0002890)	2.80269773
61	urea cycle (GO:0000050)	2.79963863
62	negative regulation of fibrinolysis (GO:0051918)	2.79917952
63	regulation of interleukin-5 production (GO:0032674)	2.78505887
64	tolerance induction (GO:0002507)	2.77923153
65	phospholipid efflux (GO:0033700)	2.74321185
66	regulation of protein activation cascade (GO:2000257)	2.74169561
67	muscle atrophy (GO:0014889)	2.71087454
68	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	2.70831827
69	epithelial cell-cell adhesion (GO:0090136)	2.70359306
70	bile acid and bile salt transport (GO:0015721)	2.69832537
71	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.69315079
72	negative regulation of cholesterol transport (GO:0032375)	2.69164131
73	negative regulation of sterol transport (GO:0032372)	2.69164131
74	cholesterol efflux (GO:0033344)	2.68150332
75	microtubule bundle formation (GO:0001578)	2.67044313
76	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.66015024
77	positive regulation of extracellular matrix organization (GO:1903055)	2.65290207
78	vocalization behavior (GO:0071625)	2.64849929
79	negative regulation of fatty acid biosynthetic process (GO:0045717)	2.63551475
80	retinal metabolic process (GO:0042574)	2.63278389
81	progesterone metabolic process (GO:0042448)	2.63062817
82	fibrinolysis (GO:0042730)	2.62651497
83	androgen metabolic process (GO:0008209)	2.62352086
84	regulation of complement activation (GO:0030449)	2.61282147
85	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.58701148
86	L-phenylalanine metabolic process (GO:0006558)	2.58701148
87	phosphatidylcholine biosynthetic process (GO:0006656)	2.58662602
88	phospholipid homeostasis (GO:0055091)	2.55849494
89	auditory receptor cell differentiation (GO:0042491)	2.55672292
90	hypotonic response (GO:0006971)	2.54465748
91	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.54430392
92	L-phenylalanine catabolic process (GO:0006559)	2.54430392
93	retinoic acid metabolic process (GO:0042573)	2.53603782
94	quaternary ammonium group transport (GO:0015697)	2.52903278
95	retinol metabolic process (GO:0042572)	2.51147482
96	negative regulation of lipase activity (GO:0060192)	2.51062904
97	left/right axis specification (GO:0070986)	2.50546045
98	xenobiotic metabolic process (GO:0006805)	2.49085964
99	regulation of interleukin-13 production (GO:0032656)	2.48929457
100	axonemal dynein complex assembly (GO:0070286)	10.2623348

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.56472512
2	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.05975931
3	ESR2_21235772_ChIP-Seq_MCF-7_Human	3.04150025
4	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.61362343
5	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.60269064
6	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.60260792
7	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.52191446
8	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.48531650
9	DROSHA_22980978_ChIP-Seq_HELA_Human	2.46768742
10	SOX2_27498859_Chip-Seq_STOMACH_Mouse	2.31883791
11	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.18017761
12	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.15096278
13	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.10400857
14	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.06820131
15	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.04746682
16	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.97220497
17	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.96512698
18	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.92644913
19	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.92392594
20	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.89828589
21	AHR_22903824_ChIP-Seq_MCF-7_Human	1.85784270
22	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.79157506
23	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.76489325
24	SOX2_20726797_ChIP-Seq_SW620_Human	1.72171118
25	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.71942553
26	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.67026237
27	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.66209328
28	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.61563704
29	RACK7_27058665_Chip-Seq_MCF-7_Human	1.61216082
30	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.59969765
31	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.59517779
32	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.57482476
33	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.55491638
34	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.54371779
35	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.53494082
36	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.46630680
37	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.45497183
38	GATA6_25053715_ChIP-Seq_YYC3_Human	1.43946404
39	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.42041130
40	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.40382549
41	KLF5_25053715_ChIP-Seq_YYC3_Human	1.37417340
42	GATA4_25053715_ChIP-Seq_YYC3_Human	1.34054371
43	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.33440884
44	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.32927639
45	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.31770169
46	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.30547189
47	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.28795871
48	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.28400159
49	SMC4_20622854_ChIP-Seq_HELA_Human	1.24450915
50	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.23343076
51	TP63_22573176_ChIP-Seq_HFKS_Human	1.21061367
52	LXR_22292898_ChIP-Seq_THP-1_Human	1.20124571
53	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.20050256
54	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.19910725
55	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.16731662
56	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.15325140
57	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.14309342
58	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.13306104
59	CREB1_26743006_Chip-Seq_LNCaP_Human	1.10747007
60	TP63_23658742_ChIP-Seq_EP156T_Human	1.10677969
61	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.09745865
62	GATA1_19941826_ChIP-Seq_K562_Human	1.08728978
63	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07791514
64	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.05945709
65	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.04903667
66	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.02797465
67	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.02797465
68	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.02796128
69	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.00120137
70	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.99773951
71	GATA2_19941826_ChIP-Seq_K562_Human	0.98907886
72	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.97230734
73	KDM2B_26808549_Chip-Seq_K562_Human	0.95813559
74	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.92324817
75	CTCF_27219007_Chip-Seq_Bcells_Human	0.91661831
76	TCF7_22412390_ChIP-Seq_EML_Mouse	0.90320611
77	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.90123770
78	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.89052087
79	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.88879625
80	CEBPB_22108803_ChIP-Seq_LS180_Human	0.88223455
81	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	0.87423954
82	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	0.87423954
83	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.86736847
84	STAT1_20625510_ChIP-Seq_HELA_Human	0.86669554
85	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.86227981
86	CDX2_22108803_ChIP-Seq_LS180_Human	0.85927418
87	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.85381636
88	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	0.84129707
89	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.84115615
90	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.82518793
91	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.81590699
92	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.81021320
93	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.80898527
94	P68_20966046_ChIP-Seq_HELA_Human	0.80101781
95	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.78276675
96	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.77433639
97	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.77247063
98	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.76656811
99	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.75900901
100	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.75287244

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	5.83087797
2	MP0002139_abnormal_hepatobiliary_system	5.47496189
3	MP0008875_abnormal_xenobiotic_pharmacok	4.45110251
4	MP0005365_abnormal_bile_salt	3.90150967
5	MP0002132_abnormal_respiratory_system	3.42576434
6	MP0004043_abnormal_pH_regulation	2.98966387
7	MP0009780_abnormal_chondrocyte_physiolo	2.79987262
8	MP0000566_synostosis	2.76738374
9	MP0005085_abnormal_gallbladder_physiolo	2.70969454
10	MP0005360_urolithiasis	2.39939493
11	MP0003252_abnormal_bile_duct	2.22713999
12	MP0001666_abnormal_nutrient_absorption	2.20840088
13	MP0005451_abnormal_body_composition	2.19634552
14	MP0009840_abnormal_foam_cell	2.15199655
15	MP0010678_abnormal_skin_adnexa	1.96866087
16	MP0001984_abnormal_olfaction	1.92870392
17	MP0004264_abnormal_extraembryonic_tissu	1.82619354
18	MP0003191_abnormal_cellular_cholesterol	1.69480009
19	MP0001765_abnormal_ion_homeostasis	1.69221311
20	MP0002168_other_aberrant_phenotype	1.68183032
21	MP0002796_impaired_skin_barrier	1.67569042
22	MP0002277_abnormal_respiratory_mucosa	1.62571209
23	MP0000751_myopathy	1.61743664
24	MP0003868_abnormal_feces_composition	1.61422700
25	MP0004019_abnormal_vitamin_homeostasis	1.60304965
26	MP0003646_muscle_fatigue	1.60278262
27	MP0010329_abnormal_lipoprotein_level	1.58596732
28	MP0002653_abnormal_ependyma_morphology	1.58265869
29	MP0003453_abnormal_keratinocyte_physiol	1.57576991
30	MP0002822_catalepsy	1.50017477
31	MP0002138_abnormal_hepatobiliary_system	1.47062880
32	MP0005670_abnormal_white_adipose	1.46696555
33	MP0003866_abnormal_defecation	1.46623258
34	MP0003045_fibrosis	1.45672002
35	MP0005083_abnormal_biliary_tract	1.43485791
36	MP0010155_abnormal_intestine_physiology	1.31402892
37	MP0002098_abnormal_vibrissa_morphology	1.29401390
38	MP0005076_abnormal_cell_differentiation	1.28134526
39	MP0000383_abnormal_hair_follicle	1.27725750
40	MP0005023_abnormal_wound_healing	1.22234159
41	MP0002249_abnormal_larynx_morphology	1.22053694
42	MP0003283_abnormal_digestive_organ	1.21198685
43	MP0000678_abnormal_parathyroid_gland	1.20833521
44	MP0003656_abnormal_erythrocyte_physiolo	1.20427089
45	MP0002971_abnormal_brown_adipose	1.18440124
46	MP0000467_abnormal_esophagus_morphology	1.17361288
47	MP0002118_abnormal_lipid_homeostasis	1.16993379
48	MP0005636_abnormal_mineral_homeostasis	1.16073484
49	MP0004145_abnormal_muscle_electrophysio	1.11677242
50	MP0010030_abnormal_orbit_morphology	1.09005462
51	MP0009643_abnormal_urine_homeostasis	1.08525953
52	MP0003183_abnormal_peptide_metabolism	1.07815411
53	MP0002876_abnormal_thyroid_physiology	1.05155084
54	MP0005395_other_phenotype	1.03273104
55	MP0000747_muscle_weakness	1.00975495
56	MP0004782_abnormal_surfactant_physiolog	1.00756190
57	MP0005666_abnormal_adipose_tissue	1.00691639
58	MP0004270_analgesia	0.98945436
59	MP0001664_abnormal_digestion	0.94963549
60	MP0005332_abnormal_amino_acid	0.94570798
61	MP0000609_abnormal_liver_physiology	0.94383965
62	MP0003806_abnormal_nucleotide_metabolis	0.93798313
63	MP0004036_abnormal_muscle_relaxation	0.91956880
64	MP0000733_abnormal_muscle_development	0.88598902
65	MP0005409_darkened_coat_color	0.87896312
66	MP0005319_abnormal_enzyme/_coenzyme	0.87827425
67	MP0003879_abnormal_hair_cell	0.86034953
68	MP0004133_heterotaxia	0.80091708
69	MP0004087_abnormal_muscle_fiber	0.79849933
70	MP0001849_ear_inflammation	0.78760743
71	MP0002108_abnormal_muscle_morphology	0.78487133
72	MP0005310_abnormal_salivary_gland	0.76610512
73	MP0005501_abnormal_skin_physiology	0.74683453
74	MP0001216_abnormal_epidermal_layer	0.74597192
75	MP0002136_abnormal_kidney_physiology	0.73730827
76	MP0000477_abnormal_intestine_morphology	0.72596922
77	MP0002896_abnormal_bone_mineralization	0.71963255
78	MP0003091_abnormal_cell_migration	0.71314828
79	MP0008789_abnormal_olfactory_epithelium	0.70636273
80	MP0002078_abnormal_glucose_homeostasis	0.69172393
81	MP0003195_calcinosis	0.69115517
82	MP0004883_abnormal_blood_vessel	0.68924852
83	MP0000249_abnormal_blood_vessel	0.68016806
84	MP0001756_abnormal_urination	0.67882660
85	MP0005375_adipose_tissue_phenotype	0.67151940
86	MP0002282_abnormal_trachea_morphology	0.63005522
87	MP0000762_abnormal_tongue_morphology	0.62079257
88	MP0005408_hypopigmentation	0.61615269
89	MP0002106_abnormal_muscle_physiology	0.61388316
90	MP0000462_abnormal_digestive_system	0.61293783
91	MP0002060_abnormal_skin_morphology	0.60705643
92	MP0001502_abnormal_circadian_rhythm	0.60683804
93	MP0003566_abnormal_cell_adhesion	0.60227261
94	MP0001485_abnormal_pinna_reflex	0.60206972
95	MP0001944_abnormal_pancreas_morphology	0.60042238
96	MP0005369_muscle_phenotype	0.59243046
97	MP0004510_myositis	0.59178470
98	MP0009642_abnormal_blood_homeostasis	0.58449982
99	MP0010630_abnormal_cardiac_muscle	0.57745831
100	MP0001346_abnormal_lacrimal_gland	0.57017419

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	8.98133913
2	Abnormal respiratory epithelium morphology (HP:0012253)	8.05652126
3	Abnormal respiratory motile cilium morphology (HP:0005938)	8.05652126
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	7.65025510
5	Absent/shortened dynein arms (HP:0200106)	7.65025510
6	Abnormal respiratory motile cilium physiology (HP:0012261)	7.64998261
7	Abnormal ciliary motility (HP:0012262)	7.39506550
8	Rhinitis (HP:0012384)	6.98210672
9	Chronic bronchitis (HP:0004469)	6.44387189
10	Bronchiectasis (HP:0002110)	5.88805455
11	Nasal polyposis (HP:0100582)	5.41928375
12	Hyperactive renin-angiotensin system (HP:0000841)	5.14025915
13	Abnormality of monocarboxylic acid metabolism (HP:0010996)	4.57413371
14	Abnormality of the nasal mucosa (HP:0000433)	4.56683972
15	Hyperkalemia (HP:0002153)	4.08716100
16	Recurrent sinusitis (HP:0011108)	3.72939875
17	Bronchitis (HP:0012387)	3.51404620
18	Male infertility (HP:0003251)	3.45521888
19	Recurrent otitis media (HP:0000403)	3.26303699
20	Decreased circulating renin level (HP:0003351)	3.12429823
21	Infertility (HP:0000789)	3.12096471
22	Exercise-induced myalgia (HP:0003738)	3.05781353
23	Atelectasis (HP:0100750)	3.02107138
24	Intrahepatic cholestasis (HP:0001406)	2.99737213
25	Chronic sinusitis (HP:0011109)	2.89455712
26	Right ventricular cardiomyopathy (HP:0011663)	2.85800419
27	Abnormality of chloride homeostasis (HP:0011422)	2.78318330
28	Chronic hepatic failure (HP:0100626)	2.72678781
29	Abnormality of renin-angiotensin system (HP:0000847)	2.58443646
30	Abnormality of the fingertips (HP:0001211)	2.34584375
31	Fat malabsorption (HP:0002630)	2.32740216
32	Hemorrhage of the eye (HP:0011885)	2.24957413
33	Renal salt wasting (HP:0000127)	2.24445405
34	Deep venous thrombosis (HP:0002625)	2.24389065
35	Malnutrition (HP:0004395)	2.23340632
36	Hyperaldosteronism (HP:0000859)	2.20666253
37	Conjugated hyperbilirubinemia (HP:0002908)	2.19035204
38	Hyponatremia (HP:0002902)	2.14912939
39	Tubulointerstitial nephritis (HP:0001970)	2.13610524
40	Flat acetabular roof (HP:0003180)	2.12954643
41	Steatorrhea (HP:0002570)	2.12404187
42	Chronic otitis media (HP:0000389)	2.12379014
43	Complement deficiency (HP:0004431)	2.11546386
44	Upper limb amyotrophy (HP:0009129)	2.00575485
45	Distal upper limb amyotrophy (HP:0007149)	2.00575485
46	Ulnar deviation of the wrist (HP:0003049)	1.96329433
47	Mildly elevated creatine phosphokinase (HP:0008180)	1.93732090
48	Progressive sensorineural hearing impairment (HP:0000408)	1.93456982
49	Obstructive sleep apnea (HP:0002870)	1.92073042
50	Abnormality of vitamin metabolism (HP:0100508)	1.91208762
51	Stridor (HP:0010307)	1.89936912
52	Glomerulonephritis (HP:0000099)	1.89470391
53	Distal lower limb muscle weakness (HP:0009053)	1.87055856
54	Self-mutilation (HP:0000742)	1.83823449
55	Cystic liver disease (HP:0006706)	1.80816250
56	Abnormality of the dental root (HP:0006486)	1.79096271
57	Taurodontia (HP:0000679)	1.79096271
58	Abnormality of permanent molar morphology (HP:0011071)	1.79096271
59	Abnormality of molar morphology (HP:0011070)	1.74180031
60	Abnormality of molar (HP:0011077)	1.74180031
61	Lip pit (HP:0100267)	1.73142448
62	Hand muscle atrophy (HP:0009130)	1.72474993
63	Cone-rod dystrophy (HP:0000548)	1.72027712
64	Abnormality of small intestinal villus morphology (HP:0011472)	1.71560281
65	Villous atrophy (HP:0011473)	1.71560281
66	Ileus (HP:0002595)	1.70535188
67	Vascular calcification (HP:0004934)	1.70472788
68	Tetraparesis (HP:0002273)	1.69507259
69	Abnormality of potassium homeostasis (HP:0011042)	1.69128289
70	Bifid scrotum (HP:0000048)	1.68465155
71	Abnormality of the dental pulp (HP:0006479)	1.68420471
72	Absent frontal sinuses (HP:0002688)	1.68224663
73	Prolonged partial thromboplastin time (HP:0003645)	1.67426947
74	Abnormality of complement system (HP:0005339)	1.67166905
75	Bell-shaped thorax (HP:0001591)	1.62495394
76	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.62206826
77	Increased density of long bones (HP:0006392)	1.58937360
78	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.58836535
79	Myopathic facies (HP:0002058)	1.57807221
80	Muscle fiber splitting (HP:0003555)	1.57707925
81	Delayed CNS myelination (HP:0002188)	1.56457135
82	Nephritis (HP:0000123)	1.55383355
83	Heterotopia (HP:0002282)	1.55109819
84	Systemic lupus erythematosus (HP:0002725)	1.55038278
85	Muscle fiber inclusion bodies (HP:0100299)	1.52822417
86	Short nail (HP:0001799)	1.51402316
87	Recurrent bronchitis (HP:0002837)	1.49979103
88	Hypotension (HP:0002615)	1.48453146
89	Akinesia (HP:0002304)	1.48231906
90	Hyporeflexia of lower limbs (HP:0002600)	1.46791930
91	Focal segmental glomerulosclerosis (HP:0000097)	1.46151498
92	Abnormality of the gastric mucosa (HP:0004295)	1.45480883
93	Abnormality of sodium homeostasis (HP:0010931)	1.42255052
94	Cardiovascular calcification (HP:0011915)	1.41973192
95	Progressive hearing impairment (HP:0001730)	1.37566104
96	Nuclear cataract (HP:0100018)	1.36656293
97	Hypobetalipoproteinemia (HP:0003563)	1.35730646
98	Difficulty running (HP:0009046)	1.34984654
99	Proximal amyotrophy (HP:0007126)	1.33310630
100	Occipital encephalocele (HP:0002085)	1.31806784

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST1R	5.32199233
2	EPHA2	4.86273470
3	MAPK15	4.20513082
4	LMTK2	3.45499150
5	MET	3.08978622
6	RIPK1	2.55343070
7	MAP3K13	2.49689204
8	SIK1	2.19899955
9	ICK	2.02383427
10	TRIB3	2.02159631
11	MAP3K2	1.90401471
12	MST4	1.88729186
13	OBSCN	1.86027053
14	MAP3K7	1.82712859
15	MAPKAPK3	1.81301711
16	NME1	1.64605926
17	PHKG2	1.52739507
18	PHKG1	1.52739507
19	EEF2K	1.47324288
20	CDK12	1.43686263
21	MAP3K9	1.43294125
22	ERN1	1.40923081
23	ERBB2	1.40471032
24	STK24	1.39770553
25	BLK	1.34616688
26	STK39	1.24211318
27	IRAK3	1.19001690
28	PRKAA2	1.16877116
29	MARK2	1.16528939
30	FGFR4	1.16132862
31	TRPM7	1.13369627
32	EPHB1	1.09816330
33	WNK4	1.08400016
34	EPHA3	1.07160156
35	CAMK1D	0.99828642
36	CAMK1G	0.97654928
37	PRKG2	0.92201109
38	EPHB2	0.89711918
39	TBK1	0.89482080
40	TTN	0.89357312
41	PRKAA1	0.84744981
42	ARAF	0.80754721
43	TAOK1	0.80012810
44	CDC42BPA	0.77357681
45	PAK3	0.76975790
46	CHUK	0.76737768
47	MAP3K3	0.71720726
48	KSR1	0.71337916
49	KSR2	0.70192659
50	PDPK1	0.69890844
51	RPS6KA2	0.65038216
52	CDK9	0.63872699
53	EIF2AK1	0.63435850
54	MAP3K1	0.62423518
55	SGK3	0.61350429
56	TNK2	0.60762637
57	MTOR	0.60435378
58	FGFR3	0.59634940
59	CAMK2G	0.59162245
60	SMG1	0.58635940
61	NEK6	0.58135482
62	FER	0.57898060
63	RPS6KB2	0.56341004
64	INSRR	0.53922097
65	MAP2K6	0.51036309
66	STK38	0.48832238
67	SGK1	0.48431967
68	LRRK2	0.48146011
69	PIK3CA	0.45039603
70	CAMK2B	0.44513330
71	MAP3K14	0.44365930
72	SIK3	0.43528511
73	DYRK1B	0.42049256
74	MAP2K1	0.41919461
75	DDR2	0.41805344
76	CAMK4	0.39460395
77	PRKCZ	0.38813180
78	RIPK4	0.38602146
79	ILK	0.38345410
80	ACVR1B	0.37927159
81	PTK6	0.37572321
82	CAMKK1	0.37570399
83	PDK1	0.37410576
84	WNK1	0.37047452
85	BMX	0.36308515
86	PRKD2	0.36061202
87	CSK	0.34410264
88	MAPK12	0.33769382
89	MAPK11	0.33752997
90	DMPK	0.33367306
91	PRKCH	0.31525396
92	SGK2	0.30765124
93	SIK2	0.29707677
94	MAPK10	0.29092881
95	LATS1	0.28959487
96	PTK2	0.27475219
97	TYK2	0.27196957
98	EPHA4	0.26339566
99	MARK1	0.25763608
100	MAPKAPK5	0.25301834

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	3.76890832
2	Caffeine metabolism_Homo sapiens_hsa00232	3.66699944
3	Phenylalanine metabolism_Homo sapiens_hsa00360	3.51779572
4	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.50953267
5	Chemical carcinogenesis_Homo sapiens_hsa05204	3.28088287
6	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.79797329
7	Histidine metabolism_Homo sapiens_hsa00340	2.74952753
8	Retinol metabolism_Homo sapiens_hsa00830	2.62847268
9	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.56507641
10	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.41720498
11	Tyrosine metabolism_Homo sapiens_hsa00350	2.36454391
12	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.00268919
13	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.90095612
14	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.84163876
15	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.74310290
16	Complement and coagulation cascades_Homo sapiens_hsa04610	1.71483052
17	beta-Alanine metabolism_Homo sapiens_hsa00410	1.65506444
18	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.60125870
19	Fatty acid degradation_Homo sapiens_hsa00071	1.58769728
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.53947729
21	Bile secretion_Homo sapiens_hsa04976	1.50468439
22	ABC transporters_Homo sapiens_hsa02010	1.48930200
23	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.48273821
24	Arginine biosynthesis_Homo sapiens_hsa00220	1.43340026
25	PPAR signaling pathway_Homo sapiens_hsa03320	1.42268587
26	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.34869549
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.27664813
28	Butanoate metabolism_Homo sapiens_hsa00650	1.16188012
29	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.08406127
30	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.07073311
31	Notch signaling pathway_Homo sapiens_hsa04330	1.04462680
32	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.03940649
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.03931829
34	Tight junction_Homo sapiens_hsa04530	1.02174497
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.99498406
36	Adherens junction_Homo sapiens_hsa04520	0.96563354
37	Insulin resistance_Homo sapiens_hsa04931	0.94138314
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.83503575
39	Sulfur metabolism_Homo sapiens_hsa00920	0.81149366
40	Peroxisome_Homo sapiens_hsa04146	0.73561257
41	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.73280916
42	Glutathione metabolism_Homo sapiens_hsa00480	0.73000573
43	Glucagon signaling pathway_Homo sapiens_hsa04922	0.71400453
44	Lysine degradation_Homo sapiens_hsa00310	0.71309537
45	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.68612666
46	Other glycan degradation_Homo sapiens_hsa00511	0.68338433
47	Circadian rhythm_Homo sapiens_hsa04710	0.68277035
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.68137886
49	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.64658398
50	AMPK signaling pathway_Homo sapiens_hsa04152	0.62118335
51	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.61253711
52	Choline metabolism in cancer_Homo sapiens_hsa05231	0.57256819
53	Arginine and proline metabolism_Homo sapiens_hsa00330	0.56670151
54	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.56035112
55	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.54865491
56	Renal cell carcinoma_Homo sapiens_hsa05211	0.54517258
57	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.53407634
58	Insulin signaling pathway_Homo sapiens_hsa04910	0.53082229
59	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.52255761
60	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.51044548
61	Hepatitis C_Homo sapiens_hsa05160	0.50343787
62	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.49978719
63	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.48898602
64	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.48598864
65	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.45366926
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.44007241
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.43562879
68	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.43102488
69	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.40595725
70	Fatty acid metabolism_Homo sapiens_hsa01212	0.38742498
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37968060
72	Amoebiasis_Homo sapiens_hsa05146	0.37168405
73	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.36243588
74	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.35519344
75	Sphingolipid metabolism_Homo sapiens_hsa00600	0.34841094
76	Endometrial cancer_Homo sapiens_hsa05213	0.33886089
77	Salivary secretion_Homo sapiens_hsa04970	0.32342465
78	Pancreatic secretion_Homo sapiens_hsa04972	0.31787994
79	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.31650735
80	Type II diabetes mellitus_Homo sapiens_hsa04930	0.31509572
81	mTOR signaling pathway_Homo sapiens_hsa04150	0.29913764
82	Mineral absorption_Homo sapiens_hsa04978	0.29087869
83	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.28315609
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.28153445
85	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.24001869
86	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.23639399
87	ErbB signaling pathway_Homo sapiens_hsa04012	0.22847808
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.22279221
89	Carbon metabolism_Homo sapiens_hsa01200	0.22275997
90	GnRH signaling pathway_Homo sapiens_hsa04912	0.22079052
91	Pancreatic cancer_Homo sapiens_hsa05212	0.21208643
92	Cocaine addiction_Homo sapiens_hsa05030	0.20669989
93	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.19740059
94	Galactose metabolism_Homo sapiens_hsa00052	0.19447382
95	Acute myeloid leukemia_Homo sapiens_hsa05221	0.17673295
96	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.16772115
97	Pentose phosphate pathway_Homo sapiens_hsa00030	0.16558175
98	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.15897259
99	Amphetamine addiction_Homo sapiens_hsa05031	0.15845315
100	Prostate cancer_Homo sapiens_hsa05215	0.15523724

MUC20P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »