ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	transepithelial transport (GO:0070633)	9.20273322
2	apical protein localization (GO:0045176)	7.80744929
3	desmosome organization (GO:0002934)	7.57038171
4	establishment of skin barrier (GO:0061436)	7.50555498
5	negative regulation of bone mineralization (GO:0030502)	7.35295461
6	epidermis development (GO:0008544)	6.79589286
7	hair cell differentiation (GO:0035315)	6.77093862
8	negative regulation of biomineral tissue development (GO:0070168)	6.45319349
9	regulation of water loss via skin (GO:0033561)	6.25124502
10	membrane raft organization (GO:0031579)	5.62107902
11	ectoderm development (GO:0007398)	5.59379620
12	long-chain fatty acid biosynthetic process (GO:0042759)	5.55580338
13	asymmetric protein localization (GO:0008105)	5.29217786
14	multicellular organismal water homeostasis (GO:0050891)	5.28220040
15	lipoxygenase pathway (GO:0019372)	5.19590612
16	localization within membrane (GO:0051668)	4.98947727
17	negative regulation of homotypic cell-cell adhesion (GO:0034111)	4.91911154
18	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	4.74122142
19	superoxide anion generation (GO:0042554)	4.68098335
20	water homeostasis (GO:0030104)	4.62290516
21	eyelid development in camera-type eye (GO:0061029)	4.62023040
22	positive regulation of endothelial cell differentiation (GO:0045603)	4.60236398
23	hair follicle morphogenesis (GO:0031069)	4.59253609
24	keratinocyte development (GO:0003334)	4.41936380
25	negative regulation of interleukin-17 production (GO:0032700)	4.35183574
26	establishment of planar polarity (GO:0001736)	4.26912408
27	establishment of tissue polarity (GO:0007164)	4.26912408
28	regulation of ruffle assembly (GO:1900027)	4.10346638
29	regulation of platelet aggregation (GO:0090330)	4.00605025
30	regulation of mitochondrial depolarization (GO:0051900)	3.97341073
31	epithelial cell differentiation (GO:0030855)	3.96237601
32	L-fucose metabolic process (GO:0042354)	3.94352122
33	L-fucose catabolic process (GO:0042355)	3.94352122
34	fucose catabolic process (GO:0019317)	3.94352122
35	keratinocyte proliferation (GO:0043616)	3.93038812
36	linoleic acid metabolic process (GO:0043651)	3.84354884
37	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.81312286
38	response to phenylpropanoid (GO:0080184)	3.64085527
39	negative regulation of cytokine-mediated signaling pathway (GO:0001960)	3.52400025
40	intestinal epithelial cell development (GO:0060576)	3.48471896
41	regulation of endothelial cell differentiation (GO:0045601)	3.43208342
42	regulation of integrin-mediated signaling pathway (GO:2001044)	3.41753736
43	positive regulation of p38MAPK cascade (GO:1900745)	3.37140148
44	positive regulation of chemokine biosynthetic process (GO:0045080)	3.29416917
45	negative regulation of response to cytokine stimulus (GO:0060761)	3.28034307
46	citrulline biosynthetic process (GO:0019240)	3.21557288
47	positive regulation of vesicle fusion (GO:0031340)	3.20012047
48	epithelium development (GO:0060429)	3.19496991
49	negative regulation of platelet activation (GO:0010544)	3.13089758
50	positive regulation of vasodilation (GO:0045909)	3.10546070
51	regulation of hippo signaling (GO:0035330)	3.05998597
52	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.03822473
53	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.03822473
54	* O-glycan processing (GO:0016266)	3.02390120
55	negative regulation of interferon-gamma production (GO:0032689)	3.02303912
56	defense response to fungus (GO:0050832)	3.02303707
57	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	3.01115057
58	keratinization (GO:0031424)	22.7491392
59	regulation of interleukin-17 production (GO:0032660)	2.99763608
60	regulation of protein polyubiquitination (GO:1902914)	2.89247567
61	early endosome to late endosome transport (GO:0045022)	2.88655526
62	wound healing (GO:0042060)	2.88487666
63	regulation of interferon-beta biosynthetic process (GO:0045357)	2.83670322
64	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.82616727
65	regulation of neuron projection regeneration (GO:0070570)	2.80778466
66	regulation of axon regeneration (GO:0048679)	2.80778466
67	excretion (GO:0007588)	2.75397511
68	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.62055469
69	regulation of T cell migration (GO:2000404)	2.59760098
70	hypotonic response (GO:0006971)	2.59572534
71	antimicrobial humoral response (GO:0019730)	2.56711158
72	regulation of pH (GO:0006885)	2.55279937
73	regulation of type 2 immune response (GO:0002828)	2.53467165
74	regulation of cholesterol homeostasis (GO:2000188)	2.48858650
75	endosome organization (GO:0007032)	2.48138996
76	lymph node development (GO:0048535)	2.45768523
77	gap junction assembly (GO:0016264)	2.43894083
78	fucosylation (GO:0036065)	2.40992815
79	negative regulation of keratinocyte proliferation (GO:0010839)	2.39271328
80	detection of bacterium (GO:0016045)	2.35756515
81	primary alcohol catabolic process (GO:0034310)	2.35348175
82	regulation of developmental pigmentation (GO:0048070)	2.34142008
83	negative regulation of cytokine secretion (GO:0050710)	2.33133185
84	hair cycle (GO:0042633)	2.30449427
85	molting cycle (GO:0042303)	2.30449427
86	leukocyte aggregation (GO:0070486)	2.29454708
87	* protein O-linked glycosylation (GO:0006493)	2.28695722
88	regulation of p38MAPK cascade (GO:1900744)	2.26963664
89	regulation of chemokine biosynthetic process (GO:0045073)	2.25514848
90	regulation of natural killer cell differentiation (GO:0032823)	2.22938846
91	regulation of toll-like receptor 4 signaling pathway (GO:0034143)	2.20750854
92	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	2.18871607
93	negative regulation of acute inflammatory response (GO:0002674)	2.18645704
94	regulation of membrane depolarization (GO:0003254)	2.18054667
95	leukocyte migration involved in inflammatory response (GO:0002523)	2.17755825
96	negative regulation of protein localization to cell surface (GO:2000009)	2.16930978
97	one-carbon compound transport (GO:0019755)	2.16886723
98	peptide cross-linking (GO:0018149)	19.6920370
99	keratinocyte differentiation (GO:0030216)	15.2535472
100	epidermal cell differentiation (GO:0009913)	12.4597146

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.55681855
2	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.88108199
3	ESR1_21235772_ChIP-Seq_MCF-7_Human	3.87727876
4	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	3.35666271
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.18264278
6	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.01550757
7	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.01144145
8	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.60332732
9	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.41336834
10	P63_26484246_Chip-Seq_KERATINOCYTES_Human	2.16569642
11	SOX2_20726797_ChIP-Seq_SW620_Human	2.10904935
12	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.05120767
13	FOXM1_26456572_ChIP-Seq_MCF-7_Human	2.00681718
14	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.99678817
15	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.97312160
16	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.97312160
17	ZNF274_21170338_ChIP-Seq_K562_Hela	1.96620772
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.85607647
19	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.83172613
20	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.79712224
21	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.77406988
22	ERG_20517297_ChIP-Seq_VCAP_Human	1.75050688
23	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.74517983
24	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.70923944
25	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.69132469
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.64860652
27	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.64801156
28	CJUN_26792858_Chip-Seq_BT549_Human	1.64782539
29	AR_25329375_ChIP-Seq_VCAP_Human	1.64492641
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.63589712
31	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.63520587
32	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.62865488
33	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.62455326
34	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.61417773
35	AHR_22903824_ChIP-Seq_MCF-7_Human	1.61044863
36	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.59346639
37	RXR_22108803_ChIP-Seq_LS180_Human	1.57147040
38	KLF5_25053715_ChIP-Seq_YYC3_Human	1.56021550
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.53105767
40	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.47784076
41	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.47100394
42	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.46856970
43	GATA4_25053715_ChIP-Seq_YYC3_Human	1.46489047
44	RBPJ_21746931_ChIP-Seq_IB4_Human	1.46372291
45	HTT_18923047_ChIP-ChIP_STHdh_Human	1.45648503
46	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.45172937
47	TP63_23658742_ChIP-Seq_EP156T_Human	1.43691260
48	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.43512362
49	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.41979494
50	HOXB7_26014856_ChIP-Seq_BT474_Human	1.38942707
51	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.37939627
52	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.32797827
53	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.32640167
54	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.32080398
55	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.29001447
56	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.27330870
57	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.24729737
58	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.24729737
59	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.24334519
60	CEBPB_22108803_ChIP-Seq_LS180_Human	1.23324940
61	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.20914749
62	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.18918932
63	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.18164442
64	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.17207787
65	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.17056226
66	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16989321
67	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.16021056
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.12656905
69	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.11443173
70	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.10097040
71	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	1.07292300
72	AR_20517297_ChIP-Seq_VCAP_Human	1.06589045
73	SMAD4_21799915_ChIP-Seq_A2780_Human	1.06237161
74	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.06132395
75	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.05358173
76	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.04990262
77	CDX2_22108803_ChIP-Seq_LS180_Human	1.02145176
78	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.01146735
79	NFYB_21822215_ChIP-Seq_K562_Human	1.00801879
80	TCF4_22108803_ChIP-Seq_LS180_Human	1.00367838
81	PHF8_20622853_ChIP-Seq_HELA_Human	0.98910623
82	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.98725457
83	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.98407483
84	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.97963115
85	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.97339334
86	P300_19829295_ChIP-Seq_ESCs_Human	0.96976221
87	AR_21572438_ChIP-Seq_LNCaP_Human	0.96974429
88	ETV1_20927104_ChIP-Seq_GIST48_Human	0.96969052
89	GATA6_25053715_ChIP-Seq_YYC3_Human	0.95780905
90	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.95609178
91	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.95364504
92	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94419116
93	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.93925836
94	TCF4_23295773_ChIP-Seq_U87_Human	0.92788347
95	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.92511053
96	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.92511053
97	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.92038479
98	STAT3_23295773_ChIP-Seq_U87_Human	0.90309150
99	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.89842636
100	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.89602217

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004043_abnormal_pH_regulation	7.66738307
2	MP0002796_impaired_skin_barrier	6.05407107
3	MP0010678_abnormal_skin_adnexa	3.82526063
4	MP0005275_abnormal_skin_tensile	3.73901790
5	MP0005501_abnormal_skin_physiology	3.69856520
6	MP0000467_abnormal_esophagus_morphology	3.39731348
7	MP0010352_gastrointestinal_tract_polyps	2.48293508
8	MP0002095_abnormal_skin_pigmentation	2.19744565
9	MP0000465_gastrointestinal_hemorrhage	2.10352154
10	MP0004885_abnormal_endolymph	2.04542641
11	MP0010234_abnormal_vibrissa_follicle	12.8438917
12	MP0002098_abnormal_vibrissa_morphology	1.92263885
13	MP0003453_abnormal_keratinocyte_physiol	1.90208603
14	MP0001216_abnormal_epidermal_layer	1.86605641
15	MP0000762_abnormal_tongue_morphology	1.82457691
16	MP0010771_integument_phenotype	1.76697605
17	MP0000371_diluted_coat_color	1.73068074
18	MP0000383_abnormal_hair_follicle	1.71253585
19	MP0009780_abnormal_chondrocyte_physiolo	1.61723938
20	MP0004185_abnormal_adipocyte_glucose	1.40313242
21	MP0001851_eye_inflammation	1.35022391
22	MP0005377_hearing/vestibular/ear_phenot	1.33138558
23	MP0003878_abnormal_ear_physiology	1.33138558
24	MP0000377_abnormal_hair_follicle	1.32844702
25	MP0000470_abnormal_stomach_morphology	1.28512284
26	MP0000579_abnormal_nail_morphology	1.27216795
27	MP0001765_abnormal_ion_homeostasis	1.26525766
28	MP0004264_abnormal_extraembryonic_tissu	1.16308823
29	MP0001243_abnormal_dermal_layer	1.15625813
30	MP0000427_abnormal_hair_cycle	1.14068053
31	MP0000613_abnormal_salivary_gland	1.00399538
32	MP0008875_abnormal_xenobiotic_pharmacok	0.99251850
33	MP0002138_abnormal_hepatobiliary_system	0.92058754
34	MP0000678_abnormal_parathyroid_gland	0.91134526
35	MP0005503_abnormal_tendon_morphology	0.89958583
36	MP0005670_abnormal_white_adipose	0.86290875
37	MP0005636_abnormal_mineral_homeostasis	0.86076793
38	MP0000566_synostosis	0.85364733
39	MP0005666_abnormal_adipose_tissue	0.83436208
40	MP0000367_abnormal_coat/_hair	0.80129677
41	MP0005365_abnormal_bile_salt	0.77766907
42	MP0002254_reproductive_system_inflammat	0.74694526
43	MP0003724_increased_susceptibility_to	0.73692129
44	MP0009053_abnormal_anal_canal	0.72127618
45	MP0002075_abnormal_coat/hair_pigmentati	0.71649826
46	MP0001502_abnormal_circadian_rhythm	0.69328994
47	MP0009931_abnormal_skin_appearance	0.66023169
48	MP0001784_abnormal_fluid_regulation	0.65347732
49	MP0010386_abnormal_urinary_bladder	0.63198672
50	MP0001756_abnormal_urination	0.62548703
51	MP0002249_abnormal_larynx_morphology	0.61220802
52	MP0009333_abnormal_splenocyte_physiolog	0.61188923
53	MP0001485_abnormal_pinna_reflex	0.60008647
54	MP0000631_abnormal_neuroendocrine_gland	0.59694352
55	MP0010030_abnormal_orbit_morphology	0.58492826
56	MP0000049_abnormal_middle_ear	0.57924921
57	MP0005375_adipose_tissue_phenotype	0.57568012
58	MP0009046_muscle_twitch	0.57295976
59	MP0004947_skin_inflammation	0.56341939
60	MP0009643_abnormal_urine_homeostasis	0.55884940
61	MP0002234_abnormal_pharynx_morphology	0.53331149
62	MP0000647_abnormal_sebaceous_gland	0.51819238
63	MP0002136_abnormal_kidney_physiology	0.51360523
64	MP0002060_abnormal_skin_morphology	0.49872786
65	MP0002653_abnormal_ependyma_morphology	0.49508965
66	MP0005409_darkened_coat_color	0.49262402
67	MP0001186_pigmentation_phenotype	0.47827270
68	MP0005253_abnormal_eye_physiology	0.47752233
69	MP0002876_abnormal_thyroid_physiology	0.47520450
70	MP0001270_distended_abdomen	0.46328557
71	MP0001501_abnormal_sleep_pattern	0.45069926
72	MP0004019_abnormal_vitamin_homeostasis	0.44031190
73	MP0008789_abnormal_olfactory_epithelium	0.42805345
74	MP0010368_abnormal_lymphatic_system	0.42715633
75	MP0003937_abnormal_limbs/digits/tail_de	0.41156778
76	MP0005646_abnormal_pituitary_gland	0.41095686
77	MP0000681_abnormal_thyroid_gland	0.39755310
78	MP0005083_abnormal_biliary_tract	0.37859918
79	MP0003638_abnormal_response/metabolism_	0.34153565
80	MP0004782_abnormal_surfactant_physiolog	0.33706134
81	MP0003755_abnormal_palate_morphology	0.32615025
82	MP0003950_abnormal_plasma_membrane	0.32475075
83	MP0008872_abnormal_physiological_respon	0.30753881
84	MP0003011_delayed_dark_adaptation	0.29349228
85	MP0009115_abnormal_fat_cell	0.28778139
86	MP0003828_pulmonary_edema	0.28398784
87	MP0000230_abnormal_systemic_arterial	0.28338906
88	MP0003195_calcinosis	0.27286768
89	MP0008995_early_reproductive_senescence	0.26886258
90	MP0005023_abnormal_wound_healing	0.26455750
91	MP0001984_abnormal_olfaction	0.25705474
92	MP0005166_decreased_susceptibility_to	0.25602149
93	MP0003646_muscle_fatigue	0.24972897
94	MP0005310_abnormal_salivary_gland	0.24964698
95	MP0003633_abnormal_nervous_system	0.24675621
96	MP0005193_abnormal_anterior_eye	0.23596196
97	MP0002166_altered_tumor_susceptibility	0.22659798
98	MP0003566_abnormal_cell_adhesion	0.22582341
99	MP0001340_abnormal_eyelid_morphology	0.22366143
100	MP0004484_altered_response_of	0.20689169

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Erythroderma (HP:0001019)	8.12291778
2	Pustule (HP:0200039)	7.92931191
3	Increased IgE level (HP:0003212)	7.70645049
4	Congenital ichthyosiform erythroderma (HP:0007431)	7.20085062
5	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	6.81551351
6	Lip pit (HP:0100267)	6.35398472
7	Hyperactive renin-angiotensin system (HP:0000841)	5.38137940
8	Palmoplantar hyperkeratosis (HP:0000972)	5.27958362
9	Palmar hyperkeratosis (HP:0010765)	5.08170915
10	Villous atrophy (HP:0011473)	4.89824361
11	Abnormality of small intestinal villus morphology (HP:0011472)	4.89824361
12	Abnormality of nail color (HP:0100643)	4.73102248
13	Parakeratosis (HP:0001036)	4.70103854
14	Brittle hair (HP:0002299)	4.29449687
15	Hyperkalemia (HP:0002153)	4.17625507
16	Decreased circulating renin level (HP:0003351)	4.11704142
17	Plantar hyperkeratosis (HP:0007556)	4.11148596
18	Sparse scalp hair (HP:0002209)	3.97647667
19	Erythema (HP:0010783)	3.94686364
20	Nasal polyposis (HP:0100582)	3.88918445
21	Chronic bronchitis (HP:0004469)	3.69903514
22	Fragile nails (HP:0001808)	3.52415570
23	Furrowed tongue (HP:0000221)	3.49113190
24	Corneal erosion (HP:0200020)	3.46887168
25	Ectropion (HP:0000656)	3.44030245
26	Hypokalemic alkalosis (HP:0001949)	3.43265946
27	Alopecia of scalp (HP:0002293)	3.37492576
28	Dehydration (HP:0001944)	3.33455629
29	Hypotrichosis (HP:0001006)	3.23529533
30	Cystic hygroma (HP:0000476)	3.21262192
31	Abnormality of chloride homeostasis (HP:0011422)	3.18468487
32	Abnormality of the salivary glands (HP:0010286)	3.17874204
33	Abnormality of the nasal mucosa (HP:0000433)	3.15036135
34	Renal salt wasting (HP:0000127)	3.13918184
35	Abnormality of renin-angiotensin system (HP:0000847)	3.12367411
36	Hyperaldosteronism (HP:0000859)	3.12330127
37	Acanthosis nigricans (HP:0000956)	3.00625110
38	Nail dystrophy (HP:0008404)	2.99628489
39	Right ventricular cardiomyopathy (HP:0011663)	2.98872111
40	Absent eyelashes (HP:0000561)	2.94880003
41	Abnormality of the axillary hair (HP:0100134)	2.86306443
42	Abnormality of secondary sexual hair (HP:0009888)	2.86306443
43	Absent hair (HP:0002298)	2.66229427
44	Absence seizures (HP:0002121)	2.63017468
45	Urticaria (HP:0001025)	2.60418941
46	Hypoplastic labia majora (HP:0000059)	2.49547416
47	Delusions (HP:0000746)	2.48010444
48	Autoamputation (HP:0001218)	2.44878947
49	Oligodontia (HP:0000677)	2.42005108
50	Hypohidrosis (HP:0000966)	2.39519655
51	Woolly hair (HP:0002224)	2.35154328
52	Neonatal hypoglycemia (HP:0001998)	2.32576833
53	Abnormality of the labia majora (HP:0012881)	2.23615695
54	Onycholysis (HP:0001806)	2.17742252
55	Fine hair (HP:0002213)	2.16524152
56	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.16226485
57	Thickened nuchal skin fold (HP:0000474)	2.15229241
58	Popliteal pterygium (HP:0009756)	2.13024987
59	Gangrene (HP:0100758)	2.11939785
60	Dialeptic seizures (HP:0011146)	2.10358822
61	Curly hair (HP:0002212)	2.06338992
62	Labial hypoplasia (HP:0000066)	2.03714500
63	Oral leukoplakia (HP:0002745)	14.3219711
64	Hoarse voice (HP:0001609)	1.98435547
65	Hypergammaglobulinemia (HP:0010702)	1.96464203
66	Palmoplantar keratoderma (HP:0000982)	1.95809548
67	Malnutrition (HP:0004395)	1.91931543
68	Abnormality of potassium homeostasis (HP:0011042)	1.89024440
69	Hypoplastic female external genitalia (HP:0012815)	1.81706898
70	Sparse eyelashes (HP:0000653)	1.81301767
71	Melanocytic nevus (HP:0000995)	1.81165233
72	Eczematoid dermatitis (HP:0000976)	1.78060904
73	Seborrheic dermatitis (HP:0001051)	1.74104901
74	Coarse hair (HP:0002208)	1.71366563
75	Acne (HP:0001061)	1.70828871
76	Amniotic constriction ring (HP:0009775)	1.68684816
77	Abnormality of placental membranes (HP:0011409)	1.68684816
78	Pruritus (HP:0000989)	1.68143858
79	Low posterior hairline (HP:0002162)	1.66981293
80	Dry skin (HP:0000958)	1.66543990
81	Hyponatremia (HP:0002902)	1.62874493
82	Blepharitis (HP:0000498)	1.61019924
83	Adrenal overactivity (HP:0002717)	1.58233533
84	Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)	1.58056445
85	Hyperventilation (HP:0002883)	1.57267552
86	Asthma (HP:0002099)	1.57066473
87	Absent eyebrow (HP:0002223)	1.55581209
88	Papilloma (HP:0012740)	1.54653490
89	Verrucae (HP:0200043)	1.54653490
90	Alkalosis (HP:0001948)	1.54444358
91	Abnormality of the labia (HP:0000058)	1.53944562
92	Tubular atrophy (HP:0000092)	1.53514361
93	Recurrent corneal erosions (HP:0000495)	1.53231419
94	Hypokalemia (HP:0002900)	1.51912224
95	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.51412307
96	Cupped ear (HP:0000378)	1.50818015
97	Choroideremia (HP:0001139)	1.49869998
98	Emphysema (HP:0002097)	1.49066046
99	Skin pits (HP:0100276)	1.47108467
100	Abnormality of macular pigmentation (HP:0008002)	1.46467958

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K2	3.98472859
2	MAP3K9	3.69562075
3	MST4	3.53021228
4	EPHA2	3.38750336
5	WNK4	3.15198219
6	MAPKAPK3	3.11202351
7	MAP3K3	2.99724008
8	NME1	2.94343485
9	ERBB3	2.82645847
10	STK39	2.70168210
11	FRK	2.67487900
12	CAMK1D	2.26514481
13	WNK1	2.24394798
14	TRPM7	2.21899943
15	CAMK1G	1.95562031
16	LATS1	1.89852891
17	IRAK1	1.72663386
18	TYRO3	1.70201648
19	BCR	1.69114918
20	WNK3	1.62809367
21	FER	1.62393474
22	STK24	1.57103282
23	BMPR1B	1.56838293
24	SGK2	1.56344145
25	SGK3	1.38155080
26	TAOK1	1.36243740
27	ADRBK2	1.33310277
28	NUAK1	1.27357976
29	PINK1	1.26079606
30	MAP4K2	1.24827648
31	DAPK2	1.20886320
32	SGK494	1.20360559
33	SGK223	1.20360559
34	LRRK2	1.16402675
35	MAP3K6	1.15820518
36	MAP2K6	1.13443076
37	MST1R	1.12706640
38	MARK2	1.09926343
39	OXSR1	1.09508241
40	GRK1	1.05874843
41	STK3	1.02973253
42	MAP3K7	1.01174027
43	MAP3K12	1.00664267
44	STK38L	0.97730939
45	PRKAA2	0.96004511
46	IRAK2	0.89953067
47	MAP3K4	0.87907506
48	ACVR1B	0.84273223
49	TAOK3	0.83578382
50	CASK	0.80003691
51	PAK3	0.74751243
52	AKT3	0.72301599
53	PRKCE	0.70119763
54	MET	0.69635071
55	FGFR1	0.68281358
56	PRKCI	0.64500203
57	TGFBR1	0.63802675
58	GRK6	0.63083903
59	DMPK	0.57433726
60	RIPK1	0.56272220
61	MAP2K1	0.53656874
62	IRAK4	0.50103294
63	RPS6KB2	0.48528518
64	FGR	0.47634110
65	PRKD2	0.46235373
66	PIK3CA	0.46114760
67	ADRBK1	0.44185838
68	SGK1	0.42988246
69	NLK	0.42091484
70	CHUK	0.41468197
71	KSR2	0.41372091
72	MAPK13	0.40690850
73	MYLK	0.39607210
74	PDGFRB	0.39158266
75	CSK	0.38307716
76	IKBKE	0.37608971
77	CSNK1A1L	0.36356398
78	PRKCZ	0.35725130
79	CAMK1	0.35551294
80	RPS6KB1	0.34440454
81	AKT2	0.33652555
82	CAMK4	0.33357719
83	PIK3CG	0.33026387
84	SIK3	0.32997749
85	PRKCQ	0.31225464
86	PKN1	0.30105631
87	EPHB2	0.29919361
88	EIF2AK3	0.29155124
89	IKBKB	0.28950462
90	STK38	0.28673692
91	INSRR	0.26947836
92	MAPKAPK5	0.26286133
93	KSR1	0.25999480
94	ATM	0.23145042
95	PRKAA1	0.21239740
96	STK11	0.19916134
97	EGFR	0.19232500
98	ABL1	0.19082909
99	GRK5	0.18977714
100	MAPKAPK2	0.18496036

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	5.26637648
2	Circadian rhythm_Homo sapiens_hsa04710	3.74250821
3	Salivary secretion_Homo sapiens_hsa04970	3.42089152
4	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	3.36386170
5	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.67763059
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.60426077
7	Sulfur metabolism_Homo sapiens_hsa00920	2.42082427
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.23460122
9	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.10502345
10	Phototransduction_Homo sapiens_hsa04744	2.08666301
11	Chemical carcinogenesis_Homo sapiens_hsa05204	2.01032068
12	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.90889990
13	Ether lipid metabolism_Homo sapiens_hsa00565	1.86857459
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.78860298
15	Collecting duct acid secretion_Homo sapiens_hsa04966	1.73397785
16	Histidine metabolism_Homo sapiens_hsa00340	1.57737908
17	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.57190514
18	Retinol metabolism_Homo sapiens_hsa00830	1.46097621
19	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.45807953
20	Adherens junction_Homo sapiens_hsa04520	1.41965055
21	Tight junction_Homo sapiens_hsa04530	1.35731864
22	Serotonergic synapse_Homo sapiens_hsa04726	1.34737988
23	beta-Alanine metabolism_Homo sapiens_hsa00410	1.32393133
24	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.32379724
25	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.28089884
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.23636340
27	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.16520179
28	Sphingolipid metabolism_Homo sapiens_hsa00600	1.12035512
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.03125850
30	Glutathione metabolism_Homo sapiens_hsa00480	0.98966655
31	Taste transduction_Homo sapiens_hsa04742	0.98825215
32	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.92936267
33	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.92011299
34	Mineral absorption_Homo sapiens_hsa04978	0.88920100
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83072715
36	Tyrosine metabolism_Homo sapiens_hsa00350	0.79301314
37	Amoebiasis_Homo sapiens_hsa05146	0.77722155
38	Endocytosis_Homo sapiens_hsa04144	0.77036787
39	GnRH signaling pathway_Homo sapiens_hsa04912	0.76752884
40	Caffeine metabolism_Homo sapiens_hsa00232	0.75058538
41	Pertussis_Homo sapiens_hsa05133	0.74058608
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.73056778
43	Notch signaling pathway_Homo sapiens_hsa04330	0.71228235
44	Butanoate metabolism_Homo sapiens_hsa00650	0.69657795
45	Ras signaling pathway_Homo sapiens_hsa04014	0.69212500
46	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.68945576
47	Lysine degradation_Homo sapiens_hsa00310	0.68397351
48	Axon guidance_Homo sapiens_hsa04360	0.66962447
49	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.66283549
50	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.65231241
51	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.64778358
52	Long-term depression_Homo sapiens_hsa04730	0.64415798
53	African trypanosomiasis_Homo sapiens_hsa05143	0.60631711
54	Fatty acid degradation_Homo sapiens_hsa00071	0.59976919
55	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.58730001
56	Acute myeloid leukemia_Homo sapiens_hsa05221	0.58655483
57	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.58200528
58	Tuberculosis_Homo sapiens_hsa05152	0.54081722
59	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.53538932
60	Renin secretion_Homo sapiens_hsa04924	0.52719774
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52347195
62	Rheumatoid arthritis_Homo sapiens_hsa05323	0.52004869
63	Hepatitis C_Homo sapiens_hsa05160	0.51770799
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.50266148
65	PPAR signaling pathway_Homo sapiens_hsa03320	0.49708853
66	Renal cell carcinoma_Homo sapiens_hsa05211	0.49130080
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.48585755
68	Influenza A_Homo sapiens_hsa05164	0.48319337
69	Pancreatic secretion_Homo sapiens_hsa04972	0.46443113
70	FoxO signaling pathway_Homo sapiens_hsa04068	0.46096196
71	Phenylalanine metabolism_Homo sapiens_hsa00360	0.44440874
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.44297806
73	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.44226077
74	TNF signaling pathway_Homo sapiens_hsa04668	0.42224264
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41947644
76	Choline metabolism in cancer_Homo sapiens_hsa05231	0.41066520
77	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.40177164
78	Asthma_Homo sapiens_hsa05310	0.39991559
79	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.39680345
80	Hippo signaling pathway_Homo sapiens_hsa04390	0.38533134
81	Platelet activation_Homo sapiens_hsa04611	0.37650586
82	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.37537332
83	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.35875595
84	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.35161588
85	Glucagon signaling pathway_Homo sapiens_hsa04922	0.34760381
86	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.34680748
87	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.34566735
88	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.33505065
89	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.33425575
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33321269
91	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.32923643
92	Insulin resistance_Homo sapiens_hsa04931	0.32882130
93	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.32720510
94	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.32560357
95	Regulation of autophagy_Homo sapiens_hsa04140	0.32034706
96	Salmonella infection_Homo sapiens_hsa05132	0.30915028
97	Insulin signaling pathway_Homo sapiens_hsa04910	0.30864829
98	Vibrio cholerae infection_Homo sapiens_hsa05110	0.28534468
99	Glutamatergic synapse_Homo sapiens_hsa04724	0.28232484
100	MAPK signaling pathway_Homo sapiens_hsa04010	0.27835734

MUC21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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