MUC21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transepithelial transport (GO:0070633)9.20273322
2apical protein localization (GO:0045176)7.80744929
3desmosome organization (GO:0002934)7.57038171
4establishment of skin barrier (GO:0061436)7.50555498
5negative regulation of bone mineralization (GO:0030502)7.35295461
6epidermis development (GO:0008544)6.79589286
7hair cell differentiation (GO:0035315)6.77093862
8negative regulation of biomineral tissue development (GO:0070168)6.45319349
9regulation of water loss via skin (GO:0033561)6.25124502
10membrane raft organization (GO:0031579)5.62107902
11ectoderm development (GO:0007398)5.59379620
12long-chain fatty acid biosynthetic process (GO:0042759)5.55580338
13asymmetric protein localization (GO:0008105)5.29217786
14multicellular organismal water homeostasis (GO:0050891)5.28220040
15lipoxygenase pathway (GO:0019372)5.19590612
16localization within membrane (GO:0051668)4.98947727
17negative regulation of homotypic cell-cell adhesion (GO:0034111)4.91911154
18positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)4.74122142
19superoxide anion generation (GO:0042554)4.68098335
20water homeostasis (GO:0030104)4.62290516
21eyelid development in camera-type eye (GO:0061029)4.62023040
22positive regulation of endothelial cell differentiation (GO:0045603)4.60236398
23hair follicle morphogenesis (GO:0031069)4.59253609
24keratinocyte development (GO:0003334)4.41936380
25negative regulation of interleukin-17 production (GO:0032700)4.35183574
26establishment of tissue polarity (GO:0007164)4.26912408
27establishment of planar polarity (GO:0001736)4.26912408
28regulation of ruffle assembly (GO:1900027)4.10346638
29regulation of platelet aggregation (GO:0090330)4.00605025
30regulation of mitochondrial depolarization (GO:0051900)3.97341073
31epithelial cell differentiation (GO:0030855)3.96237601
32fucose catabolic process (GO:0019317)3.94352122
33L-fucose metabolic process (GO:0042354)3.94352122
34L-fucose catabolic process (GO:0042355)3.94352122
35keratinocyte proliferation (GO:0043616)3.93038812
36linoleic acid metabolic process (GO:0043651)3.84354884
37bundle of His cell to Purkinje myocyte communication (GO:0086069)3.81312286
38response to phenylpropanoid (GO:0080184)3.64085527
39negative regulation of cytokine-mediated signaling pathway (GO:0001960)3.52400025
40intestinal epithelial cell development (GO:0060576)3.48471896
41regulation of endothelial cell differentiation (GO:0045601)3.43208342
42regulation of integrin-mediated signaling pathway (GO:2001044)3.41753736
43positive regulation of p38MAPK cascade (GO:1900745)3.37140148
44positive regulation of chemokine biosynthetic process (GO:0045080)3.29416917
45negative regulation of response to cytokine stimulus (GO:0060761)3.28034307
46citrulline biosynthetic process (GO:0019240)3.21557288
47positive regulation of vesicle fusion (GO:0031340)3.20012047
48epithelium development (GO:0060429)3.19496991
49negative regulation of platelet activation (GO:0010544)3.13089758
50positive regulation of vasodilation (GO:0045909)3.10546070
51regulation of hippo signaling (GO:0035330)3.05998597
52purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.03822473
533-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.03822473
54* O-glycan processing (GO:0016266)3.02390120
55negative regulation of interferon-gamma production (GO:0032689)3.02303912
56defense response to fungus (GO:0050832)3.02303707
57negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.01115057
58keratinization (GO:0031424)22.7491392
59regulation of interleukin-17 production (GO:0032660)2.99763608
60regulation of protein polyubiquitination (GO:1902914)2.89247567
61early endosome to late endosome transport (GO:0045022)2.88655526
62wound healing (GO:0042060)2.88487666
63regulation of interferon-beta biosynthetic process (GO:0045357)2.83670322
64regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.82616727
65regulation of neuron projection regeneration (GO:0070570)2.80778466
66regulation of axon regeneration (GO:0048679)2.80778466
67excretion (GO:0007588)2.75397511
68planar cell polarity pathway involved in neural tube closure (GO:0090179)2.62055469
69regulation of T cell migration (GO:2000404)2.59760098
70hypotonic response (GO:0006971)2.59572534
71antimicrobial humoral response (GO:0019730)2.56711158
72regulation of pH (GO:0006885)2.55279937
73regulation of type 2 immune response (GO:0002828)2.53467165
74regulation of cholesterol homeostasis (GO:2000188)2.48858650
75endosome organization (GO:0007032)2.48138996
76lymph node development (GO:0048535)2.45768523
77gap junction assembly (GO:0016264)2.43894083
78fucosylation (GO:0036065)2.40992815
79negative regulation of keratinocyte proliferation (GO:0010839)2.39271328
80detection of bacterium (GO:0016045)2.35756515
81primary alcohol catabolic process (GO:0034310)2.35348175
82regulation of developmental pigmentation (GO:0048070)2.34142008
83negative regulation of cytokine secretion (GO:0050710)2.33133185
84molting cycle (GO:0042303)2.30449427
85hair cycle (GO:0042633)2.30449427
86leukocyte aggregation (GO:0070486)2.29454708
87* protein O-linked glycosylation (GO:0006493)2.28695722
88regulation of p38MAPK cascade (GO:1900744)2.26963664
89regulation of chemokine biosynthetic process (GO:0045073)2.25514848
90regulation of natural killer cell differentiation (GO:0032823)2.22938846
91regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.20750854
92regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.18871607
93negative regulation of acute inflammatory response (GO:0002674)2.18645704
94regulation of membrane depolarization (GO:0003254)2.18054667
95leukocyte migration involved in inflammatory response (GO:0002523)2.17755825
96negative regulation of protein localization to cell surface (GO:2000009)2.16930978
97one-carbon compound transport (GO:0019755)2.16886723
98peptide cross-linking (GO:0018149)19.6920370
99keratinocyte differentiation (GO:0030216)15.2535472
100epidermal cell differentiation (GO:0009913)12.4597146

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.55681855
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.88108199
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.87727876
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.35666271
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.18264278
6ESR1_20079471_ChIP-ChIP_T-47D_Human3.01550757
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.01144145
8ZNF217_24962896_ChIP-Seq_MCF-7_Human2.60332732
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.41336834
10P63_26484246_Chip-Seq_KERATINOCYTES_Human2.16569642
11SOX2_20726797_ChIP-Seq_SW620_Human2.10904935
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05120767
13FOXM1_26456572_ChIP-Seq_MCF-7_Human2.00681718
14ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.99678817
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.97312160
16SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.97312160
17ZNF274_21170338_ChIP-Seq_K562_Hela1.96620772
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85607647
19GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.83172613
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.79712224
21GATA3_24758297_ChIP-Seq_MCF-7_Human1.77406988
22ERG_20517297_ChIP-Seq_VCAP_Human1.75050688
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74517983
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.70923944
25FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.69132469
26BCAT_22108803_ChIP-Seq_LS180_Human1.64860652
27GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.64801156
28CJUN_26792858_Chip-Seq_BT549_Human1.64782539
29AR_25329375_ChIP-Seq_VCAP_Human1.64492641
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63589712
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63520587
32GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.62865488
33GATA6_21074721_ChIP-Seq_CACO-2_Human1.62455326
34SOX9_24532713_ChIP-Seq_HFSC_Mouse1.61417773
35AHR_22903824_ChIP-Seq_MCF-7_Human1.61044863
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59346639
37RXR_22108803_ChIP-Seq_LS180_Human1.57147040
38KLF5_25053715_ChIP-Seq_YYC3_Human1.56021550
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53105767
40ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.47784076
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47100394
42FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.46856970
43GATA4_25053715_ChIP-Seq_YYC3_Human1.46489047
44RBPJ_21746931_ChIP-Seq_IB4_Human1.46372291
45HTT_18923047_ChIP-ChIP_STHdh_Human1.45648503
46TCF4_18268006_ChIP-ChIP_LS174T_Human1.45172937
47TP63_23658742_ChIP-Seq_EP156T_Human1.43691260
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43512362
49CDX2_20551321_ChIP-Seq_CACO-2_Human1.41979494
50HOXB7_26014856_ChIP-Seq_BT474_Human1.38942707
51TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.37939627
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.32797827
53SMAD3_21741376_ChIP-Seq_HESCs_Human1.32640167
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32080398
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.29001447
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.27330870
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24729737
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24729737
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24334519
60CEBPB_22108803_ChIP-Seq_LS180_Human1.23324940
61JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20914749
62FOXH1_21741376_ChIP-Seq_EPCs_Human1.18918932
63AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18164442
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17207787
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17056226
66TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.16989321
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16021056
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12656905
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.11443173
70CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.10097040
71FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.07292300
72AR_20517297_ChIP-Seq_VCAP_Human1.06589045
73SMAD4_21799915_ChIP-Seq_A2780_Human1.06237161
74FOXH1_21741376_ChIP-Seq_ESCs_Human1.06132395
75FOXA1_25552417_ChIP-Seq_VCAP_Human1.05358173
76SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04990262
77CDX2_22108803_ChIP-Seq_LS180_Human1.02145176
78JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01146735
79NFYB_21822215_ChIP-Seq_K562_Human1.00801879
80TCF4_22108803_ChIP-Seq_LS180_Human1.00367838
81PHF8_20622853_ChIP-Seq_HELA_Human0.98910623
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98725457
83EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98407483
84HNFA_21074721_ChIP-Seq_CACO-2_Human0.97963115
85SMAD4_21741376_ChIP-Seq_HESCs_Human0.97339334
86P300_19829295_ChIP-Seq_ESCs_Human0.96976221
87AR_21572438_ChIP-Seq_LNCaP_Human0.96974429
88ETV1_20927104_ChIP-Seq_GIST48_Human0.96969052
89GATA6_25053715_ChIP-Seq_YYC3_Human0.95780905
90GATA2_21666600_ChIP-Seq_HMVEC_Human0.95609178
91OCT1_27270436_Chip-Seq_PROSTATE_Human0.95364504
92NANOG_20526341_ChIP-Seq_ESCs_Human0.94419116
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.93925836
94TCF4_23295773_ChIP-Seq_U87_Human0.92788347
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92511053
96FOXA1_25329375_ChIP-Seq_VCAP_Human0.92511053
97TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92038479
98STAT3_23295773_ChIP-Seq_U87_Human0.90309150
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89842636
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89602217

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation7.66738307
2MP0002796_impaired_skin_barrier6.05407107
3MP0010678_abnormal_skin_adnexa3.82526063
4MP0005275_abnormal_skin_tensile3.73901790
5MP0005501_abnormal_skin_physiology3.69856520
6MP0000467_abnormal_esophagus_morphology3.39731348
7MP0010352_gastrointestinal_tract_polyps2.48293508
8MP0002095_abnormal_skin_pigmentation2.19744565
9MP0000465_gastrointestinal_hemorrhage2.10352154
10MP0004885_abnormal_endolymph2.04542641
11MP0010234_abnormal_vibrissa_follicle12.8438917
12MP0002098_abnormal_vibrissa_morphology1.92263885
13MP0003453_abnormal_keratinocyte_physiol1.90208603
14MP0001216_abnormal_epidermal_layer1.86605641
15MP0000762_abnormal_tongue_morphology1.82457691
16MP0010771_integument_phenotype1.76697605
17MP0000371_diluted_coat_color1.73068074
18MP0000383_abnormal_hair_follicle1.71253585
19MP0009780_abnormal_chondrocyte_physiolo1.61723938
20MP0004185_abnormal_adipocyte_glucose1.40313242
21MP0001851_eye_inflammation1.35022391
22MP0003878_abnormal_ear_physiology1.33138558
23MP0005377_hearing/vestibular/ear_phenot1.33138558
24MP0000377_abnormal_hair_follicle1.32844702
25MP0000470_abnormal_stomach_morphology1.28512284
26MP0000579_abnormal_nail_morphology1.27216795
27MP0001765_abnormal_ion_homeostasis1.26525766
28MP0004264_abnormal_extraembryonic_tissu1.16308823
29MP0001243_abnormal_dermal_layer1.15625813
30MP0000427_abnormal_hair_cycle1.14068053
31MP0000613_abnormal_salivary_gland1.00399538
32MP0008875_abnormal_xenobiotic_pharmacok0.99251850
33MP0002138_abnormal_hepatobiliary_system0.92058754
34MP0000678_abnormal_parathyroid_gland0.91134526
35MP0005503_abnormal_tendon_morphology0.89958583
36MP0005670_abnormal_white_adipose0.86290875
37MP0005636_abnormal_mineral_homeostasis0.86076793
38MP0000566_synostosis0.85364733
39MP0005666_abnormal_adipose_tissue0.83436208
40MP0000367_abnormal_coat/_hair0.80129677
41MP0005365_abnormal_bile_salt0.77766907
42MP0002254_reproductive_system_inflammat0.74694526
43MP0003724_increased_susceptibility_to0.73692129
44MP0009053_abnormal_anal_canal0.72127618
45MP0002075_abnormal_coat/hair_pigmentati0.71649826
46MP0001502_abnormal_circadian_rhythm0.69328994
47MP0009931_abnormal_skin_appearance0.66023169
48MP0001784_abnormal_fluid_regulation0.65347732
49MP0010386_abnormal_urinary_bladder0.63198672
50MP0001756_abnormal_urination0.62548703
51MP0002249_abnormal_larynx_morphology0.61220802
52MP0009333_abnormal_splenocyte_physiolog0.61188923
53MP0001485_abnormal_pinna_reflex0.60008647
54MP0000631_abnormal_neuroendocrine_gland0.59694352
55MP0010030_abnormal_orbit_morphology0.58492826
56MP0000049_abnormal_middle_ear0.57924921
57MP0005375_adipose_tissue_phenotype0.57568012
58MP0009046_muscle_twitch0.57295976
59MP0004947_skin_inflammation0.56341939
60MP0009643_abnormal_urine_homeostasis0.55884940
61MP0002234_abnormal_pharynx_morphology0.53331149
62MP0000647_abnormal_sebaceous_gland0.51819238
63MP0002136_abnormal_kidney_physiology0.51360523
64MP0002060_abnormal_skin_morphology0.49872786
65MP0002653_abnormal_ependyma_morphology0.49508965
66MP0005409_darkened_coat_color0.49262402
67MP0001186_pigmentation_phenotype0.47827270
68MP0005253_abnormal_eye_physiology0.47752233
69MP0002876_abnormal_thyroid_physiology0.47520450
70MP0001270_distended_abdomen0.46328557
71MP0001501_abnormal_sleep_pattern0.45069926
72MP0004019_abnormal_vitamin_homeostasis0.44031190
73MP0008789_abnormal_olfactory_epithelium0.42805345
74MP0010368_abnormal_lymphatic_system0.42715633
75MP0003937_abnormal_limbs/digits/tail_de0.41156778
76MP0005646_abnormal_pituitary_gland0.41095686
77MP0000681_abnormal_thyroid_gland0.39755310
78MP0005083_abnormal_biliary_tract0.37859918
79MP0003638_abnormal_response/metabolism_0.34153565
80MP0004782_abnormal_surfactant_physiolog0.33706134
81MP0003755_abnormal_palate_morphology0.32615025
82MP0003950_abnormal_plasma_membrane0.32475075
83MP0008872_abnormal_physiological_respon0.30753881
84MP0003011_delayed_dark_adaptation0.29349228
85MP0009115_abnormal_fat_cell0.28778139
86MP0003828_pulmonary_edema0.28398784
87MP0000230_abnormal_systemic_arterial0.28338906
88MP0003195_calcinosis0.27286768
89MP0008995_early_reproductive_senescence0.26886258
90MP0005023_abnormal_wound_healing0.26455750
91MP0001984_abnormal_olfaction0.25705474
92MP0005166_decreased_susceptibility_to0.25602149
93MP0003646_muscle_fatigue0.24972897
94MP0005310_abnormal_salivary_gland0.24964698
95MP0003633_abnormal_nervous_system0.24675621
96MP0005193_abnormal_anterior_eye0.23596196
97MP0002166_altered_tumor_susceptibility0.22659798
98MP0003566_abnormal_cell_adhesion0.22582341
99MP0001340_abnormal_eyelid_morphology0.22366143
100MP0004484_altered_response_of0.20689169

Predicted human phenotypes

RankGene SetZ-score
1Erythroderma (HP:0001019)8.12291778
2Pustule (HP:0200039)7.92931191
3Increased IgE level (HP:0003212)7.70645049
4Congenital ichthyosiform erythroderma (HP:0007431)7.20085062
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.81551351
6Lip pit (HP:0100267)6.35398472
7Hyperactive renin-angiotensin system (HP:0000841)5.38137940
8Palmoplantar hyperkeratosis (HP:0000972)5.27958362
9Palmar hyperkeratosis (HP:0010765)5.08170915
10Villous atrophy (HP:0011473)4.89824361
11Abnormality of small intestinal villus morphology (HP:0011472)4.89824361
12Abnormality of nail color (HP:0100643)4.73102248
13Parakeratosis (HP:0001036)4.70103854
14Brittle hair (HP:0002299)4.29449687
15Hyperkalemia (HP:0002153)4.17625507
16Decreased circulating renin level (HP:0003351)4.11704142
17Plantar hyperkeratosis (HP:0007556)4.11148596
18Sparse scalp hair (HP:0002209)3.97647667
19Erythema (HP:0010783)3.94686364
20Nasal polyposis (HP:0100582)3.88918445
21Chronic bronchitis (HP:0004469)3.69903514
22Fragile nails (HP:0001808)3.52415570
23Furrowed tongue (HP:0000221)3.49113190
24Corneal erosion (HP:0200020)3.46887168
25Ectropion (HP:0000656)3.44030245
26Hypokalemic alkalosis (HP:0001949)3.43265946
27Alopecia of scalp (HP:0002293)3.37492576
28Dehydration (HP:0001944)3.33455629
29Hypotrichosis (HP:0001006)3.23529533
30Cystic hygroma (HP:0000476)3.21262192
31Abnormality of chloride homeostasis (HP:0011422)3.18468487
32Abnormality of the salivary glands (HP:0010286)3.17874204
33Abnormality of the nasal mucosa (HP:0000433)3.15036135
34Renal salt wasting (HP:0000127)3.13918184
35Abnormality of renin-angiotensin system (HP:0000847)3.12367411
36Hyperaldosteronism (HP:0000859)3.12330127
37Acanthosis nigricans (HP:0000956)3.00625110
38Nail dystrophy (HP:0008404)2.99628489
39Right ventricular cardiomyopathy (HP:0011663)2.98872111
40Absent eyelashes (HP:0000561)2.94880003
41Abnormality of the axillary hair (HP:0100134)2.86306443
42Abnormality of secondary sexual hair (HP:0009888)2.86306443
43Absent hair (HP:0002298)2.66229427
44Absence seizures (HP:0002121)2.63017468
45Urticaria (HP:0001025)2.60418941
46Hypoplastic labia majora (HP:0000059)2.49547416
47Delusions (HP:0000746)2.48010444
48Autoamputation (HP:0001218)2.44878947
49Oligodontia (HP:0000677)2.42005108
50Hypohidrosis (HP:0000966)2.39519655
51Woolly hair (HP:0002224)2.35154328
52Neonatal hypoglycemia (HP:0001998)2.32576833
53Abnormality of the labia majora (HP:0012881)2.23615695
54Onycholysis (HP:0001806)2.17742252
55Fine hair (HP:0002213)2.16524152
56Aplasia/Hypoplasia of the tongue (HP:0010295)2.16226485
57Thickened nuchal skin fold (HP:0000474)2.15229241
58Popliteal pterygium (HP:0009756)2.13024987
59Gangrene (HP:0100758)2.11939785
60Dialeptic seizures (HP:0011146)2.10358822
61Curly hair (HP:0002212)2.06338992
62Labial hypoplasia (HP:0000066)2.03714500
63Oral leukoplakia (HP:0002745)14.3219711
64Hoarse voice (HP:0001609)1.98435547
65Hypergammaglobulinemia (HP:0010702)1.96464203
66Palmoplantar keratoderma (HP:0000982)1.95809548
67Malnutrition (HP:0004395)1.91931543
68Abnormality of potassium homeostasis (HP:0011042)1.89024440
69Hypoplastic female external genitalia (HP:0012815)1.81706898
70Sparse eyelashes (HP:0000653)1.81301767
71Melanocytic nevus (HP:0000995)1.81165233
72Eczematoid dermatitis (HP:0000976)1.78060904
73Seborrheic dermatitis (HP:0001051)1.74104901
74Coarse hair (HP:0002208)1.71366563
75Acne (HP:0001061)1.70828871
76Amniotic constriction ring (HP:0009775)1.68684816
77Abnormality of placental membranes (HP:0011409)1.68684816
78Pruritus (HP:0000989)1.68143858
79Low posterior hairline (HP:0002162)1.66981293
80Dry skin (HP:0000958)1.66543990
81Hyponatremia (HP:0002902)1.62874493
82Blepharitis (HP:0000498)1.61019924
83Adrenal overactivity (HP:0002717)1.58233533
84Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.58056445
85Hyperventilation (HP:0002883)1.57267552
86Asthma (HP:0002099)1.57066473
87Absent eyebrow (HP:0002223)1.55581209
88Papilloma (HP:0012740)1.54653490
89Verrucae (HP:0200043)1.54653490
90Alkalosis (HP:0001948)1.54444358
91Abnormality of the labia (HP:0000058)1.53944562
92Tubular atrophy (HP:0000092)1.53514361
93Recurrent corneal erosions (HP:0000495)1.53231419
94Hypokalemia (HP:0002900)1.51912224
95Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.51412307
96Cupped ear (HP:0000378)1.50818015
97Choroideremia (HP:0001139)1.49869998
98Emphysema (HP:0002097)1.49066046
99Skin pits (HP:0100276)1.47108467
100Abnormality of macular pigmentation (HP:0008002)1.46467958

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K23.98472859
2MAP3K93.69562075
3MST43.53021228
4EPHA23.38750336
5WNK43.15198219
6MAPKAPK33.11202351
7MAP3K32.99724008
8NME12.94343485
9ERBB32.82645847
10STK392.70168210
11FRK2.67487900
12CAMK1D2.26514481
13WNK12.24394798
14TRPM72.21899943
15CAMK1G1.95562031
16LATS11.89852891
17IRAK11.72663386
18TYRO31.70201648
19BCR1.69114918
20WNK31.62809367
21FER1.62393474
22STK241.57103282
23BMPR1B1.56838293
24SGK21.56344145
25SGK31.38155080
26TAOK11.36243740
27ADRBK21.33310277
28NUAK11.27357976
29PINK11.26079606
30MAP4K21.24827648
31DAPK21.20886320
32SGK4941.20360559
33SGK2231.20360559
34LRRK21.16402675
35MAP3K61.15820518
36MAP2K61.13443076
37MST1R1.12706640
38MARK21.09926343
39OXSR11.09508241
40GRK11.05874843
41STK31.02973253
42MAP3K71.01174027
43MAP3K121.00664267
44STK38L0.97730939
45PRKAA20.96004511
46IRAK20.89953067
47MAP3K40.87907506
48ACVR1B0.84273223
49TAOK30.83578382
50CASK0.80003691
51PAK30.74751243
52AKT30.72301599
53PRKCE0.70119763
54MET0.69635071
55FGFR10.68281358
56PRKCI0.64500203
57TGFBR10.63802675
58GRK60.63083903
59DMPK0.57433726
60RIPK10.56272220
61MAP2K10.53656874
62IRAK40.50103294
63RPS6KB20.48528518
64FGR0.47634110
65PRKD20.46235373
66PIK3CA0.46114760
67ADRBK10.44185838
68SGK10.42988246
69NLK0.42091484
70CHUK0.41468197
71KSR20.41372091
72MAPK130.40690850
73MYLK0.39607210
74PDGFRB0.39158266
75CSK0.38307716
76IKBKE0.37608971
77CSNK1A1L0.36356398
78PRKCZ0.35725130
79CAMK10.35551294
80RPS6KB10.34440454
81AKT20.33652555
82CAMK40.33357719
83PIK3CG0.33026387
84SIK30.32997749
85PRKCQ0.31225464
86PKN10.30105631
87EPHB20.29919361
88EIF2AK30.29155124
89IKBKB0.28950462
90STK380.28673692
91INSRR0.26947836
92MAPKAPK50.26286133
93KSR10.25999480
94ATM0.23145042
95PRKAA10.21239740
96STK110.19916134
97EGFR0.19232500
98ABL10.19082909
99GRK50.18977714
100MAPKAPK20.18496036

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006015.26637648
2Circadian rhythm_Homo sapiens_hsa047103.74250821
3Salivary secretion_Homo sapiens_hsa049703.42089152
4Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.36386170
5Arachidonic acid metabolism_Homo sapiens_hsa005902.67763059
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.60426077
7Sulfur metabolism_Homo sapiens_hsa009202.42082427
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.23460122
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.10502345
10Phototransduction_Homo sapiens_hsa047442.08666301
11Chemical carcinogenesis_Homo sapiens_hsa052042.01032068
12Steroid hormone biosynthesis_Homo sapiens_hsa001401.90889990
13Ether lipid metabolism_Homo sapiens_hsa005651.86857459
14Linoleic acid metabolism_Homo sapiens_hsa005911.78860298
15Collecting duct acid secretion_Homo sapiens_hsa049661.73397785
16Histidine metabolism_Homo sapiens_hsa003401.57737908
17Dorso-ventral axis formation_Homo sapiens_hsa043201.57190514
18Retinol metabolism_Homo sapiens_hsa008301.46097621
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45807953
20Adherens junction_Homo sapiens_hsa045201.41965055
21Tight junction_Homo sapiens_hsa045301.35731864
22Serotonergic synapse_Homo sapiens_hsa047261.34737988
23beta-Alanine metabolism_Homo sapiens_hsa004101.32393133
24Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32379724
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28089884
26Nitrogen metabolism_Homo sapiens_hsa009101.23636340
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16520179
28Sphingolipid metabolism_Homo sapiens_hsa006001.12035512
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03125850
30Glutathione metabolism_Homo sapiens_hsa004800.98966655
31Taste transduction_Homo sapiens_hsa047420.98825215
32Cyanoamino acid metabolism_Homo sapiens_hsa004600.92936267
33NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92011299
34Mineral absorption_Homo sapiens_hsa049780.88920100
35Maturity onset diabetes of the young_Homo sapiens_hsa049500.83072715
36Tyrosine metabolism_Homo sapiens_hsa003500.79301314
37Amoebiasis_Homo sapiens_hsa051460.77722155
38Endocytosis_Homo sapiens_hsa041440.77036787
39GnRH signaling pathway_Homo sapiens_hsa049120.76752884
40Caffeine metabolism_Homo sapiens_hsa002320.75058538
41Pertussis_Homo sapiens_hsa051330.74058608
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73056778
43Notch signaling pathway_Homo sapiens_hsa043300.71228235
44Butanoate metabolism_Homo sapiens_hsa006500.69657795
45Ras signaling pathway_Homo sapiens_hsa040140.69212500
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68945576
47Lysine degradation_Homo sapiens_hsa003100.68397351
48Axon guidance_Homo sapiens_hsa043600.66962447
49Sphingolipid signaling pathway_Homo sapiens_hsa040710.66283549
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65231241
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.64778358
52Long-term depression_Homo sapiens_hsa047300.64415798
53African trypanosomiasis_Homo sapiens_hsa051430.60631711
54Fatty acid degradation_Homo sapiens_hsa000710.59976919
55Inositol phosphate metabolism_Homo sapiens_hsa005620.58730001
56Acute myeloid leukemia_Homo sapiens_hsa052210.58655483
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58200528
58Tuberculosis_Homo sapiens_hsa051520.54081722
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.53538932
60Renin secretion_Homo sapiens_hsa049240.52719774
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.52347195
62Rheumatoid arthritis_Homo sapiens_hsa053230.52004869
63Hepatitis C_Homo sapiens_hsa051600.51770799
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50266148
65PPAR signaling pathway_Homo sapiens_hsa033200.49708853
66Renal cell carcinoma_Homo sapiens_hsa052110.49130080
67Tryptophan metabolism_Homo sapiens_hsa003800.48585755
68Influenza A_Homo sapiens_hsa051640.48319337
69Pancreatic secretion_Homo sapiens_hsa049720.46443113
70FoxO signaling pathway_Homo sapiens_hsa040680.46096196
71Phenylalanine metabolism_Homo sapiens_hsa003600.44440874
72Ovarian steroidogenesis_Homo sapiens_hsa049130.44297806
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.44226077
74TNF signaling pathway_Homo sapiens_hsa046680.42224264
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41947644
76Choline metabolism in cancer_Homo sapiens_hsa052310.41066520
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40177164
78Asthma_Homo sapiens_hsa053100.39991559
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39680345
80Hippo signaling pathway_Homo sapiens_hsa043900.38533134
81Platelet activation_Homo sapiens_hsa046110.37650586
82Starch and sucrose metabolism_Homo sapiens_hsa005000.37537332
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35875595
84TGF-beta signaling pathway_Homo sapiens_hsa043500.35161588
85Glucagon signaling pathway_Homo sapiens_hsa049220.34760381
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34680748
87Synaptic vesicle cycle_Homo sapiens_hsa047210.34566735
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33505065
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33425575
90Glycerolipid metabolism_Homo sapiens_hsa005610.33321269
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32923643
92Insulin resistance_Homo sapiens_hsa049310.32882130
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32720510
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32560357
95Regulation of autophagy_Homo sapiens_hsa041400.32034706
96Salmonella infection_Homo sapiens_hsa051320.30915028
97Insulin signaling pathway_Homo sapiens_hsa049100.30864829
98Vibrio cholerae infection_Homo sapiens_hsa051100.28534468
99Glutamatergic synapse_Homo sapiens_hsa047240.28232484
100MAPK signaling pathway_Homo sapiens_hsa040100.27835734

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