ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of homotypic cell-cell adhesion (GO:0034111)	8.89394949
2	epidermal cell differentiation (GO:0009913)	8.64973366
3	negative regulation of bone mineralization (GO:0030502)	8.52488875
4	apical protein localization (GO:0045176)	7.72057401
5	negative regulation of biomineral tissue development (GO:0070168)	7.51974448
6	long-chain fatty acid biosynthetic process (GO:0042759)	7.03532043
7	establishment of skin barrier (GO:0061436)	6.77585480
8	positive regulation of endothelial cell differentiation (GO:0045603)	6.57303841
9	regulation of platelet aggregation (GO:0090330)	6.51775415
10	regulation of hippo signaling (GO:0035330)	5.76458712
11	hair cell differentiation (GO:0035315)	5.67193206
12	O-glycan processing (GO:0016266)	5.62003527
13	regulation of water loss via skin (GO:0033561)	5.56881156
14	lipoxygenase pathway (GO:0019372)	5.52715127
15	membrane raft organization (GO:0031579)	5.44216283
16	negative regulation of interleukin-17 production (GO:0032700)	5.41142006
17	negative regulation of platelet activation (GO:0010544)	5.27850358
18	asymmetric protein localization (GO:0008105)	5.24135558
19	linoleic acid metabolic process (GO:0043651)	5.18796854
20	superoxide anion generation (GO:0042554)	5.12918681
21	epidermis development (GO:0008544)	5.04398816
22	negative regulation of cell-cell adhesion (GO:0022408)	5.00383083
23	positive regulation of p38MAPK cascade (GO:1900745)	4.85548901
24	multicellular organismal water homeostasis (GO:0050891)	4.77761325
25	localization within membrane (GO:0051668)	4.74660524
26	regulation of endothelial cell differentiation (GO:0045601)	4.71907690
27	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	4.56482097
28	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	4.35140245
29	water homeostasis (GO:0030104)	4.27740068
30	negative regulation of cytokine-mediated signaling pathway (GO:0001960)	4.22635390
31	regulation of integrin-mediated signaling pathway (GO:2001044)	4.11770012
32	interkinetic nuclear migration (GO:0022027)	4.09790187
33	regulation of mitochondrial depolarization (GO:0051900)	4.09315941
34	enteric nervous system development (GO:0048484)	4.07102722
35	regulation of protein polyubiquitination (GO:1902914)	3.86700673
36	protein O-linked glycosylation (GO:0006493)	3.85453918
37	regulation of p38MAPK cascade (GO:1900744)	3.80365192
38	negative regulation of response to cytokine stimulus (GO:0060761)	3.77908164
39	regulation of homotypic cell-cell adhesion (GO:0034110)	3.77360551
40	regulation of bile acid biosynthetic process (GO:0070857)	3.75040867
41	positive regulation of vasodilation (GO:0045909)	3.67632880
42	positive regulation of chemokine biosynthetic process (GO:0045080)	3.55005227
43	ectoderm development (GO:0007398)	3.54499856
44	negative regulation of muscle cell apoptotic process (GO:0010656)	3.53869461
45	regulation of cholesterol homeostasis (GO:2000188)	3.49978330
46	regulation of interleukin-17 production (GO:0032660)	3.42001623
47	antimicrobial humoral response (GO:0019730)	3.41345856
48	negative regulation of protein localization to cell surface (GO:2000009)	3.39471036
49	intestinal epithelial cell development (GO:0060576)	3.35358254
50	nephron tubule formation (GO:0072079)	3.20521035
51	defense response to fungus (GO:0050832)	3.09909939
52	macroautophagy (GO:0016236)	3.07419677
53	vitamin A metabolic process (GO:0006776)	2.97296671
54	N-terminal protein amino acid acetylation (GO:0006474)	2.96116976
55	cytoplasmic mRNA processing body assembly (GO:0033962)	2.88778174
56	early endosome to late endosome transport (GO:0045022)	2.84455290
57	regulation of membrane depolarization (GO:0003254)	2.80477040
58	regulation of platelet activation (GO:0010543)	2.78692574
59	microtubule nucleation (GO:0007020)	2.78490564
60	wound healing (GO:0042060)	2.78168522
61	regulation of developmental pigmentation (GO:0048070)	2.77522684
62	regulation of interferon-beta biosynthetic process (GO:0045357)	2.76949653
63	regulation of vasodilation (GO:0042312)	2.76593420
64	hippo signaling (GO:0035329)	2.74903490
65	regulation of toll-like receptor 4 signaling pathway (GO:0034143)	2.72760375
66	response to muscle activity (GO:0014850)	2.70189865
67	desmosome organization (GO:0002934)	2.69215494
68	response to leptin (GO:0044321)	2.61859167
69	transepithelial transport (GO:0070633)	2.61190378
70	lymph node development (GO:0048535)	2.58867957
71	protein K48-linked deubiquitination (GO:0071108)	2.58090214
72	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	2.57249695
73	epithelial cell differentiation (GO:0030855)	2.55649317
74	negative regulation of cell-substrate adhesion (GO:0010812)	2.50942320
75	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.49878845
76	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.49878845
77	regulation of chemokine biosynthetic process (GO:0045073)	2.44094909
78	temperature homeostasis (GO:0001659)	2.42659191
79	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.41428568
80	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.41233823
81	positive regulation of steroid hormone secretion (GO:2000833)	2.41193368
82	epithelium development (GO:0060429)	2.40778875
83	negative regulation of ossification (GO:0030279)	2.38101477
84	regulation of oxidative phosphorylation (GO:0002082)	2.37742335
85	negative regulation of interferon-gamma production (GO:0032689)	2.37708518
86	regulation of ruffle assembly (GO:1900027)	2.36974053
87	biomineral tissue development (GO:0031214)	2.36232321
88	Rho protein signal transduction (GO:0007266)	2.34120665
89	axon ensheathment (GO:0008366)	2.32776889
90	ensheathment of neurons (GO:0007272)	2.32776889
91	endosome organization (GO:0007032)	2.32670837
92	excretion (GO:0007588)	2.31259879
93	regulation of female receptivity (GO:0045924)	2.30234430
94	protein K63-linked deubiquitination (GO:0070536)	2.28088847
95	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	2.27821012
96	endocardial cushion development (GO:0003197)	2.27791294
97	sodium ion homeostasis (GO:0055078)	2.25482682
98	keratinization (GO:0031424)	18.0893175
99	peptide cross-linking (GO:0018149)	11.9318264
100	keratinocyte differentiation (GO:0030216)	10.3455326

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.53701583
2	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.81806149
3	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.78587279
4	VDR_22108803_ChIP-Seq_LS180_Human	2.75166508
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.72895361
6	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.53577198
7	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.21806726
8	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.20816764
9	AHR_22903824_ChIP-Seq_MCF-7_Human	2.18730601
10	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.02634418
11	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.94177733
12	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.86196211
13	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.83170358
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.82743738
15	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.82457748
16	CJUN_26792858_Chip-Seq_BT549_Human	1.80895092
17	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.80757875
18	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.78086961
19	RXR_22108803_ChIP-Seq_LS180_Human	1.77188939
20	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.68671959
21	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.64123503
22	AR_21572438_ChIP-Seq_LNCaP_Human	1.62475371
23	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.59901652
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.59130143
25	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.57802343
26	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.57071170
27	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.48800389
28	SOX2_20726797_ChIP-Seq_SW620_Human	1.48742001
29	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.45008934
30	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.44207285
31	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.44207285
32	KLF5_25053715_ChIP-Seq_YYC3_Human	1.41490462
33	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.41134628
34	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.40328159
35	STAT3_23295773_ChIP-Seq_U87_Human	1.34248698
36	AR_25329375_ChIP-Seq_VCAP_Human	1.33700731
37	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.30749991
38	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.29850322
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.29069705
40	TP63_23658742_ChIP-Seq_EP156T_Human	1.28295524
41	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.28213262
42	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.27878562
43	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.26845139
44	GATA4_25053715_ChIP-Seq_YYC3_Human	1.26335765
45	ERG_20517297_ChIP-Seq_VCAP_Human	1.25838648
46	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.23420342
47	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.22732553
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.22183078
49	GBX2_23144817_ChIP-Seq_PC3_Human	1.21806283
50	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.21684041
51	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.19947146
52	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.16920232
53	DROSHA_22980978_ChIP-Seq_HELA_Human	1.16876430
54	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.16686873
55	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16545221
56	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14995186
57	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.13731896
58	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.12766741
59	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.12720318
60	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.12445250
61	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11537957
62	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.11330525
63	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10796218
64	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.10641282
65	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.08855305
66	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.08237083
67	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.07693734
68	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.07693734
69	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.07151541
70	AR_19668381_ChIP-Seq_PC3_Human	1.06950736
71	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06855659
72	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06535621
73	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.06535621
74	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.05225164
75	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.04168465
76	BCAT_22108803_ChIP-Seq_LS180_Human	1.03779631
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03285947
78	TCF4_23295773_ChIP-Seq_U87_Human	1.02587533
79	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.02441172
80	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.02229062
81	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.01384022
82	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.00735820
83	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.00735820
84	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00638850
85	RBPJ_21746931_ChIP-Seq_IB4_Human	0.98220695
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98090024
87	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.97278977
88	CDX2_22108803_ChIP-Seq_LS180_Human	0.96361809
89	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.96300329
90	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	0.95858921
91	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.95696473
92	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95451381
93	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.93519505
94	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.92303376
95	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.91744829
96	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.91515591
97	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.91291339
98	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.90607966
99	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.89854099
100	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.89217821

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004043_abnormal_pH_regulation	4.86464405
2	MP0005275_abnormal_skin_tensile	4.56931923
3	MP0002796_impaired_skin_barrier	4.34871698
4	MP0010352_gastrointestinal_tract_polyps	3.66899316
5	MP0010678_abnormal_skin_adnexa	3.54641192
6	MP0005501_abnormal_skin_physiology	3.14537014
7	MP0005670_abnormal_white_adipose	3.07189408
8	MP0009780_abnormal_chondrocyte_physiolo	2.90723685
9	MP0004185_abnormal_adipocyte_glucose	2.40947515
10	MP0004130_abnormal_muscle_cell	2.04709975
11	MP0010234_abnormal_vibrissa_follicle	12.2375172
12	MP0010368_abnormal_lymphatic_system	1.90588713
13	MP0005666_abnormal_adipose_tissue	1.81618942
14	MP0002098_abnormal_vibrissa_morphology	1.61464956
15	MP0002138_abnormal_hepatobiliary_system	1.58825155
16	MP0000678_abnormal_parathyroid_gland	1.55365706
17	MP0008004_abnormal_stomach_pH	1.55132575
18	MP0003453_abnormal_keratinocyte_physiol	1.54096054
19	MP0003806_abnormal_nucleotide_metabolis	1.44916060
20	MP0010771_integument_phenotype	1.43568177
21	MP0003646_muscle_fatigue	1.43024006
22	MP0000465_gastrointestinal_hemorrhage	1.42316493
23	MP0001502_abnormal_circadian_rhythm	1.39420047
24	MP0005365_abnormal_bile_salt	1.38950488
25	MP0003705_abnormal_hypodermis_morpholog	1.34913990
26	MP0009333_abnormal_splenocyte_physiolog	1.32961386
27	MP0005409_darkened_coat_color	1.32455876
28	MP0005375_adipose_tissue_phenotype	1.31497637
29	MP0005646_abnormal_pituitary_gland	1.22311772
30	MP0000467_abnormal_esophagus_morphology	1.20731369
31	MP0009115_abnormal_fat_cell	1.16922821
32	MP0009046_muscle_twitch	1.16331644
33	MP0002108_abnormal_muscle_morphology	1.16259561
34	MP0001216_abnormal_epidermal_layer	1.15713364
35	MP0005503_abnormal_tendon_morphology	1.15567889
36	MP0003879_abnormal_hair_cell	1.12057204
37	MP0000470_abnormal_stomach_morphology	1.01184739
38	MP0002249_abnormal_larynx_morphology	1.01034114
39	MP0010386_abnormal_urinary_bladder	1.00082048
40	MP0000920_abnormal_myelination	0.98768993
41	MP0003136_yellow_coat_color	0.96537594
42	MP0001765_abnormal_ion_homeostasis	0.95708362
43	MP0001756_abnormal_urination	0.94516119
44	MP0000377_abnormal_hair_follicle	0.93327453
45	MP0001501_abnormal_sleep_pattern	0.92455610
46	MP0000749_muscle_degeneration	0.90308911
47	MP0003950_abnormal_plasma_membrane	0.89434171
48	MP0008961_abnormal_basal_metabolism	0.88064365
49	MP0000383_abnormal_hair_follicle	0.87165925
50	MP0001485_abnormal_pinna_reflex	0.85658414
51	MP0002332_abnormal_exercise_endurance	0.84308664
52	MP0005166_decreased_susceptibility_to	0.83962110
53	MP0005266_abnormal_metabolism	0.81720299
54	MP0004885_abnormal_endolymph	0.80945437
55	MP0000003_abnormal_adipose_tissue	0.80942058
56	MP0004264_abnormal_extraembryonic_tissu	0.78174072
57	MP0004084_abnormal_cardiac_muscle	0.75991937
58	MP0006138_congestive_heart_failure	0.75667695
59	MP0000681_abnormal_thyroid_gland	0.75565829
60	MP0001784_abnormal_fluid_regulation	0.75229078
61	MP0000762_abnormal_tongue_morphology	0.73106083
62	MP0000733_abnormal_muscle_development	0.70787028
63	MP0001851_eye_inflammation	0.70438681
64	MP0000631_abnormal_neuroendocrine_gland	0.69944307
65	MP0001873_stomach_inflammation	0.69095094
66	MP0000230_abnormal_systemic_arterial	0.68024312
67	MP0003937_abnormal_limbs/digits/tail_de	0.67108380
68	MP0000049_abnormal_middle_ear	0.61640820
69	MP0002876_abnormal_thyroid_physiology	0.60815227
70	MP0000371_diluted_coat_color	0.59798589
71	MP0005448_abnormal_energy_balance	0.58937080
72	MP0002653_abnormal_ependyma_morphology	0.55747518
73	MP0001664_abnormal_digestion	0.55674334
74	MP0004036_abnormal_muscle_relaxation	0.54135637
75	MP0004947_skin_inflammation	0.53428718
76	MP0002733_abnormal_thermal_nociception	0.53317815
77	MP0002837_dystrophic_cardiac_calcinosis	0.52568602
78	MP0004484_altered_response_of	0.51482375
79	MP0003828_pulmonary_edema	0.49348862
80	MP0001879_abnormal_lymphatic_vessel	0.48975058
81	MP0005620_abnormal_muscle_contractility	0.48251738
82	MP0009643_abnormal_urine_homeostasis	0.47082630
83	MP0002095_abnormal_skin_pigmentation	0.46333103
84	MP0010329_abnormal_lipoprotein_level	0.45772913
85	MP0000569_abnormal_digit_pigmentation	0.45627987
86	MP0003633_abnormal_nervous_system	0.45048878
87	MP0005023_abnormal_wound_healing	0.44913893
88	MP0001544_abnormal_cardiovascular_syste	0.43395566
89	MP0005385_cardiovascular_system_phenoty	0.43395566
90	MP0000579_abnormal_nail_morphology	0.42384076
91	MP0000613_abnormal_salivary_gland	0.41634345
92	MP0000759_abnormal_skeletal_muscle	0.40061600
93	MP0004215_abnormal_myocardial_fiber	0.39515172
94	MP0003938_abnormal_ear_development	0.39380158
95	MP0005647_abnormal_sex_gland	0.39113697
96	MP0005464_abnormal_platelet_physiology	0.37665538
97	MP0009384_cardiac_valve_regurgitation	0.37620992
98	MP0004087_abnormal_muscle_fiber	0.37561520
99	MP0005451_abnormal_body_composition	0.37291714
100	MP0002970_abnormal_white_adipose	0.37047962

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased IgE level (HP:0003212)	8.66144428
2	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	6.85127931
3	Hyperactive renin-angiotensin system (HP:0000841)	6.28316235
4	Hyperkalemia (HP:0002153)	5.68340062
5	Lip pit (HP:0100267)	5.61761561
6	Parakeratosis (HP:0001036)	5.56346324
7	Decreased circulating renin level (HP:0003351)	5.33630434
8	Abnormality of small intestinal villus morphology (HP:0011472)	5.32099623
9	Villous atrophy (HP:0011473)	5.32099623
10	Nasal polyposis (HP:0100582)	4.75788164
11	Congenital ichthyosiform erythroderma (HP:0007431)	4.57947136
12	Hypokalemic alkalosis (HP:0001949)	4.53713938
13	Erythroderma (HP:0001019)	4.45406873
14	Neonatal hypoglycemia (HP:0001998)	4.11309424
15	Abnormality of renin-angiotensin system (HP:0000847)	4.07941070
16	Brittle hair (HP:0002299)	3.98479197
17	Chronic bronchitis (HP:0004469)	3.97244148
18	Abnormality of the nasal mucosa (HP:0000433)	3.87556804
19	Hyperaldosteronism (HP:0000859)	3.83798948
20	Sparse scalp hair (HP:0002209)	3.57285100
21	Renal salt wasting (HP:0000127)	3.46046381
22	Clumsiness (HP:0002312)	3.44586862
23	Hypoplastic ischia (HP:0003175)	3.36843673
24	Cystic hygroma (HP:0000476)	3.31950833
25	Furrowed tongue (HP:0000221)	3.30250863
26	Oligodactyly (hands) (HP:0001180)	3.20521203
27	Abnormality of chloride homeostasis (HP:0011422)	3.19298734
28	Abnormality of the ischium (HP:0003174)	3.08923462
29	Absence seizures (HP:0002121)	3.06978431
30	Dehydration (HP:0001944)	3.06488129
31	Genetic anticipation (HP:0003743)	3.05876119
32	Oligodontia (HP:0000677)	2.98123773
33	Eczematoid dermatitis (HP:0000976)	2.91748834
34	Abnormality of potassium homeostasis (HP:0011042)	2.91114089
35	Increased circulating renin level (HP:0000848)	2.90678428
36	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.87759149
37	Acanthosis nigricans (HP:0000956)	2.86741484
38	Right ventricular cardiomyopathy (HP:0011663)	2.80817568
39	Oral leukoplakia (HP:0002745)	2.58983349
40	Erythema (HP:0010783)	2.52300978
41	Hypokalemia (HP:0002900)	2.46250820
42	Alkalosis (HP:0001948)	2.42752573
43	Abnormality of the salivary glands (HP:0010286)	2.35818564
44	Dialeptic seizures (HP:0011146)	2.34004950
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.33234389
46	Abnormality of the columella (HP:0009929)	2.31146442
47	Oligodactyly (HP:0012165)	2.26562263
48	Hyporeflexia of lower limbs (HP:0002600)	2.26454555
49	Hoarse voice (HP:0001609)	2.22164890
50	Thoracolumbar scoliosis (HP:0002944)	2.14964796
51	Adrenal overactivity (HP:0002717)	2.11719129
52	Abnormality of the pubic bones (HP:0003172)	2.09699191
53	Low posterior hairline (HP:0002162)	2.06882404
54	Hyperventilation (HP:0002883)	2.03482547
55	Stenosis of the external auditory canal (HP:0000402)	2.01377675
56	Pustule (HP:0200039)	10.9525120
57	Papilloma (HP:0012740)	1.96730480
58	Verrucae (HP:0200043)	1.96730480
59	Asymmetry of the thorax (HP:0001555)	1.95040391
60	Hyponatremia (HP:0002902)	1.94405985
61	Hypoplastic labia majora (HP:0000059)	1.93725137
62	Delusions (HP:0000746)	1.89094159
63	Papillary thyroid carcinoma (HP:0002895)	1.88929803
64	Metabolic alkalosis (HP:0200114)	1.88882105
65	Skin pits (HP:0100276)	1.87570806
66	Scapular winging (HP:0003691)	1.85881148
67	Mixed hearing impairment (HP:0000410)	1.78168257
68	Abnormality of the labia majora (HP:0012881)	1.77755087
69	Choroideremia (HP:0001139)	1.77476192
70	Thickened nuchal skin fold (HP:0000474)	1.74871125
71	Abnormality of macular pigmentation (HP:0008002)	1.74574424
72	Fine hair (HP:0002213)	1.73940042
73	Asthma (HP:0002099)	1.73491134
74	Emphysema (HP:0002097)	1.73476821
75	Progressive cerebellar ataxia (HP:0002073)	1.73033103
76	Postural instability (HP:0002172)	1.70773166
77	Acne (HP:0001061)	1.69702287
78	Labial hypoplasia (HP:0000066)	1.68383502
79	Difficulty walking (HP:0002355)	1.65460520
80	Hypergammaglobulinemia (HP:0010702)	1.62044145
81	Split foot (HP:0001839)	1.59701322
82	Protruding tongue (HP:0010808)	1.57137500
83	Abnormal pancreas size (HP:0012094)	1.55594555
84	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.53975353
85	Advanced eruption of teeth (HP:0006288)	1.53418882
86	Bilateral sensorineural hearing impairment (HP:0008619)	1.52616868
87	Radioulnar synostosis (HP:0002974)	1.50488594
88	Urticaria (HP:0001025)	1.49677672
89	Ventricular fibrillation (HP:0001663)	1.48273179
90	Abnormality of sodium homeostasis (HP:0010931)	1.47874181
91	Hypoplastic female external genitalia (HP:0012815)	1.47131117
92	Prominent nose (HP:0000448)	1.46980764
93	Long eyelashes (HP:0000527)	1.46978921
94	Melanocytic nevus (HP:0000995)	1.46410798
95	Hypomagnesemia (HP:0002917)	1.45908258
96	Nail dystrophy (HP:0008404)	1.45820390
97	Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)	1.45049827
98	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.44669500
99	Obstructive sleep apnea (HP:0002870)	1.44209121
100	Lymphedema (HP:0001004)	1.38342240

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	5.77279716
2	PINK1	4.83663150
3	FRK	4.30944348
4	NME1	3.18332772
5	CAMK1D	3.06418066
6	TYRO3	3.04576810
7	STK39	2.81536282
8	WNK4	2.65743126
9	CAMK1G	2.50221235
10	DDR2	2.49925985
11	SGK2	2.46233411
12	WNK1	2.45739424
13	SGK3	2.19810015
14	LATS1	2.18080086
15	OBSCN	2.06672474
16	SGK223	1.93231026
17	SGK494	1.93231026
18	MARK3	1.82128050
19	MAP3K2	1.79100265
20	MST4	1.50403239
21	RIPK1	1.45170629
22	LRRK2	1.44786277
23	BMPR1B	1.38925563
24	TRPM7	1.32291073
25	MAP3K7	1.30078579
26	MARK2	1.28503344
27	STK38	1.28132817
28	DAPK2	1.25309467
29	PDGFRB	1.22752537
30	PRKAA2	1.21082092
31	MELK	1.16004909
32	STK38L	1.11615411
33	NEK2	1.08894618
34	ICK	1.08289557
35	AKT2	1.00349779
36	OXSR1	0.96646189
37	KSR2	0.91628341
38	MAP3K1	0.89924911
39	RPS6KB1	0.89615573
40	MET	0.89449178
41	EEF2K	0.85909253
42	STK3	0.84390841
43	PIK3CA	0.82050925
44	MAP3K3	0.78777114
45	NTRK3	0.78372844
46	IRAK1	0.73365301
47	MAP2K1	0.73136365
48	STK24	0.72258146
49	MTOR	0.70312307
50	MAPKAPK5	0.68249224
51	CDK12	0.68144689
52	CSK	0.67168760
53	FGFR1	0.64238293
54	CDK3	0.62759100
55	CHUK	0.60691719
56	ACVR1B	0.60304621
57	PKN1	0.59227295
58	SIK2	0.58276200
59	TAOK1	0.57962383
60	CDK9	0.56515196
61	CSNK1A1L	0.55863759
62	CAMK4	0.55226976
63	IRAK2	0.53091620
64	PRKG2	0.52700503
65	MAP3K13	0.51091262
66	SGK1	0.51001451
67	PRKAA1	0.50893406
68	HIPK2	0.49207013
69	AKT3	0.44722616
70	MAPKAPK3	0.43953619
71	ROCK1	0.41040648
72	EPHA2	0.40742299
73	CAMK1	0.39730335
74	GRK1	0.37731686
75	PTK2	0.36178135
76	RPS6KA2	0.35288397
77	BMX	0.35168803
78	ADRBK1	0.33238262
79	BCR	0.32640747
80	MST1R	0.31657904
81	MAPK1	0.31119126
82	INSRR	0.30809808
83	EPHB1	0.30149906
84	ADRBK2	0.29445039
85	AKT1	0.28617445
86	PRKD3	0.28273471
87	PHKG1	0.27875073
88	PHKG2	0.27875073
89	RET	0.27499092
90	PRKCQ	0.27320076
91	ITK	0.27152409
92	MAP3K4	0.26512546
93	TNIK	0.26107112
94	TRIB3	0.25868934
95	PDPK1	0.23529060
96	RPS6KA1	0.23468276
97	TAOK3	0.23078554
98	ATM	0.23006849
99	RPS6KA3	0.22186724
100	GSK3B	0.21956122

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Salivary secretion_Homo sapiens_hsa04970	4.54968482
2	Circadian rhythm_Homo sapiens_hsa04710	4.00113206
3	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	3.34242475
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.52087790
5	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.30090467
6	Adherens junction_Homo sapiens_hsa04520	2.02750220
7	Nitrogen metabolism_Homo sapiens_hsa00910	1.82798749
8	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.66631523
9	Notch signaling pathway_Homo sapiens_hsa04330	1.50886682
10	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.49203204
11	Serotonergic synapse_Homo sapiens_hsa04726	1.48421552
12	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.46544378
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.43016830
14	Tight junction_Homo sapiens_hsa04530	1.40162380
15	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.38593676
16	Lysine degradation_Homo sapiens_hsa00310	1.29534119
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.29388427
18	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.27832005
19	Collecting duct acid secretion_Homo sapiens_hsa04966	1.15485022
20	Chemical carcinogenesis_Homo sapiens_hsa05204	1.13453562
21	Gastric acid secretion_Homo sapiens_hsa04971	1.09087895
22	Platelet activation_Homo sapiens_hsa04611	1.03127535
23	Renal cell carcinoma_Homo sapiens_hsa05211	1.01156008
24	Mineral absorption_Homo sapiens_hsa04978	1.01080800
25	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.99053281
26	Linoleic acid metabolism_Homo sapiens_hsa00591	0.98988376
27	Olfactory transduction_Homo sapiens_hsa04740	0.97822252
28	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.97228233
29	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.93211824
30	Glucagon signaling pathway_Homo sapiens_hsa04922	0.93006284
31	Hippo signaling pathway_Homo sapiens_hsa04390	0.92597351
32	Taste transduction_Homo sapiens_hsa04742	0.91689982
33	beta-Alanine metabolism_Homo sapiens_hsa00410	0.90081231
34	Histidine metabolism_Homo sapiens_hsa00340	0.88052704
35	FoxO signaling pathway_Homo sapiens_hsa04068	0.88046123
36	PPAR signaling pathway_Homo sapiens_hsa03320	0.86187420
37	Thyroid cancer_Homo sapiens_hsa05216	0.85613605
38	Insulin signaling pathway_Homo sapiens_hsa04910	0.85486740
39	Glutathione metabolism_Homo sapiens_hsa00480	0.85400007
40	Ras signaling pathway_Homo sapiens_hsa04014	0.84972562
41	Sulfur metabolism_Homo sapiens_hsa00920	0.84579410
42	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.84376926
43	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.83621881
44	Gap junction_Homo sapiens_hsa04540	0.81794282
45	Long-term depression_Homo sapiens_hsa04730	0.81733687
46	Circadian entrainment_Homo sapiens_hsa04713	0.81250015
47	Butanoate metabolism_Homo sapiens_hsa00650	0.79289160
48	Insulin resistance_Homo sapiens_hsa04931	0.79245638
49	Endometrial cancer_Homo sapiens_hsa05213	0.77842439
50	Choline metabolism in cancer_Homo sapiens_hsa05231	0.76719404
51	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.75408303
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.75158554
53	Acute myeloid leukemia_Homo sapiens_hsa05221	0.73387856
54	Endocytosis_Homo sapiens_hsa04144	0.73042005
55	MAPK signaling pathway_Homo sapiens_hsa04010	0.71525472
56	AMPK signaling pathway_Homo sapiens_hsa04152	0.71518290
57	Long-term potentiation_Homo sapiens_hsa04720	0.69853432
58	Calcium signaling pathway_Homo sapiens_hsa04020	0.68805252
59	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.68202399
60	ErbB signaling pathway_Homo sapiens_hsa04012	0.67565142
61	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.67370168
62	Phototransduction_Homo sapiens_hsa04744	0.67047283
63	cAMP signaling pathway_Homo sapiens_hsa04024	0.65609647
64	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.64706543
65	GnRH signaling pathway_Homo sapiens_hsa04912	0.63033586
66	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.62999015
67	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.62682554
68	ABC transporters_Homo sapiens_hsa02010	0.61965204
69	Tryptophan metabolism_Homo sapiens_hsa00380	0.61922126
70	Prostate cancer_Homo sapiens_hsa05215	0.61424986
71	Axon guidance_Homo sapiens_hsa04360	0.60928055
72	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.59998683
73	Wnt signaling pathway_Homo sapiens_hsa04310	0.59786014
74	Prolactin signaling pathway_Homo sapiens_hsa04917	0.57243525
75	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.57105633
76	Focal adhesion_Homo sapiens_hsa04510	0.55695511
77	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.55689065
78	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.55259245
79	Rap1 signaling pathway_Homo sapiens_hsa04015	0.55012050
80	Ether lipid metabolism_Homo sapiens_hsa00565	0.53703436
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.53698174
82	Amoebiasis_Homo sapiens_hsa05146	0.53330309
83	Vibrio cholerae infection_Homo sapiens_hsa05110	0.52988998
84	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.52743382
85	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.51751716
86	Selenocompound metabolism_Homo sapiens_hsa00450	0.51316854
87	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50512206
88	GABAergic synapse_Homo sapiens_hsa04727	0.50384614
89	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.49968685
90	Type II diabetes mellitus_Homo sapiens_hsa04930	0.49837034
91	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.49322907
92	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.48836373
93	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.47533240
94	Renin secretion_Homo sapiens_hsa04924	0.46893565
95	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.46863461
96	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.45271996
97	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.44145315
98	Melanoma_Homo sapiens_hsa05218	0.43990605
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.43506927
100	VEGF signaling pathway_Homo sapiens_hsa04370	0.43407541

MUC22

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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