MUC3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation (Gendler and Spicer, 1995 [PubMed 7778880]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)8.67685264
2ethanol oxidation (GO:0006069)8.17685023
3primary alcohol catabolic process (GO:0034310)7.80755370
4regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.26446927
5regulation of female gonad development (GO:2000194)6.84962597
6epoxygenase P450 pathway (GO:0019373)6.42601151
7intestinal absorption (GO:0050892)6.41351172
8ethanol metabolic process (GO:0006067)6.34535811
9NADH metabolic process (GO:0006734)5.74069187
10fat-soluble vitamin biosynthetic process (GO:0042362)5.28879250
11regulation of bile acid biosynthetic process (GO:0070857)5.18452020
12drug metabolic process (GO:0017144)4.93703997
13antibacterial humoral response (GO:0019731)4.90351388
14vocalization behavior (GO:0071625)4.83801691
15negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.81937870
16regulation of systemic arterial blood pressure by hormone (GO:0001990)4.79367510
17regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.79367510
18endocrine process (GO:0050886)4.79367510
19regulation of triglyceride catabolic process (GO:0010896)4.78892016
20lipoprotein transport (GO:0042953)4.70539929
21fructose metabolic process (GO:0006000)4.65720940
22antimicrobial humoral response (GO:0019730)4.61684496
23urea metabolic process (GO:0019627)4.60138418
24drug catabolic process (GO:0042737)4.55021474
25hormone catabolic process (GO:0042447)4.53323054
26urea cycle (GO:0000050)4.50553840
27diacylglycerol metabolic process (GO:0046339)4.50450183
28regulation of cellular extravasation (GO:0002691)4.41801687
29cellular glucuronidation (GO:0052695)4.40571489
30regulation of systemic arterial blood pressure (GO:0003073)4.38908951
31renal system process involved in regulation of blood volume (GO:0001977)4.28298838
32glucuronate metabolic process (GO:0019585)4.28287067
33uronic acid metabolic process (GO:0006063)4.28287067
34adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.26727040
35flavonoid metabolic process (GO:0009812)4.26415582
36receptor guanylyl cyclase signaling pathway (GO:0007168)4.25010295
37nitrogen cycle metabolic process (GO:0071941)4.14942824
38regulation of cGMP biosynthetic process (GO:0030826)4.11879686
39exogenous drug catabolic process (GO:0042738)4.09783272
40phospholipid efflux (GO:0033700)4.05486311
41extracellular negative regulation of signal transduction (GO:1900116)4.03235711
42extracellular regulation of signal transduction (GO:1900115)4.03235711
43opioid receptor signaling pathway (GO:0038003)4.02986708
44bile acid and bile salt transport (GO:0015721)4.00140081
45plasma lipoprotein particle assembly (GO:0034377)3.95892033
46behavioral response to ethanol (GO:0048149)3.93867533
47maintenance of gastrointestinal epithelium (GO:0030277)3.93106326
48response to histamine (GO:0034776)3.92072099
49multicellular organismal water homeostasis (GO:0050891)3.88176894
50peptide hormone processing (GO:0016486)3.87542658
51peptide catabolic process (GO:0043171)3.86332479
52positive regulation of triglyceride lipase activity (GO:0061365)3.85445034
53positive regulation of lipoprotein lipase activity (GO:0051006)3.85445034
54triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.84593833
55regulation of glutamate receptor signaling pathway (GO:1900449)3.83653830
56regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.83118409
57alkaloid metabolic process (GO:0009820)3.81642017
58very-low-density lipoprotein particle assembly (GO:0034379)3.77063710
59bundle of His cell to Purkinje myocyte communication (GO:0086069)3.76180483
60positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.73596548
61negative regulation of complement activation (GO:0045916)3.67867918
62regulation of cholesterol homeostasis (GO:2000188)3.63855712
63regulation of cholesterol esterification (GO:0010872)3.63731139
64virion attachment to host cell (GO:0019062)3.62421733
65adhesion of symbiont to host cell (GO:0044650)3.62421733
66protein-lipid complex assembly (GO:0065005)3.62071711
67negative regulation of protein tyrosine kinase activity (GO:0061099)3.58505626
68lipoprotein metabolic process (GO:0042157)3.57297243
69negative regulation of keratinocyte proliferation (GO:0010839)3.56839648
70digestion (GO:0007586)3.54755144
71positive regulation of lipid catabolic process (GO:0050996)3.54521332
72long term synaptic depression (GO:0060292)3.54116702
73digestive system process (GO:0022600)3.53915681
74regulation of short-term neuronal synaptic plasticity (GO:0048172)3.51564117
75regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.48928520
76complement activation, classical pathway (GO:0006958)3.47227953
77arginine metabolic process (GO:0006525)3.46385599
78cardiac conduction (GO:0061337)3.45015574
79cellular response to ammonium ion (GO:0071242)3.44275250
80cGMP-mediated signaling (GO:0019934)3.41582389
81actin filament depolymerization (GO:0030042)3.38047029
82negative regulation of cytosolic calcium ion concentration (GO:0051481)3.37614017
83positive regulation of pseudopodium assembly (GO:0031274)3.36995108
84transmission of nerve impulse (GO:0019226)3.33955710
85long-chain fatty acid biosynthetic process (GO:0042759)3.33561166
86multicellular organismal signaling (GO:0035637)3.32759996
87regulation of cGMP metabolic process (GO:0030823)3.32158716
88sulfate transmembrane transport (GO:1902358)3.31653349
89locomotory exploration behavior (GO:0035641)3.30450665
90phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.29747134
91synaptic vesicle docking involved in exocytosis (GO:0016081)3.28296815
92ionotropic glutamate receptor signaling pathway (GO:0035235)3.27817500
93regulation of sodium ion transmembrane transport (GO:1902305)3.27575649
94regulation of respiratory burst (GO:0060263)3.26214378
95renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.26204862
96renal absorption (GO:0070293)3.26046360
97protein-lipid complex remodeling (GO:0034368)3.23157309
98macromolecular complex remodeling (GO:0034367)3.23157309
99plasma lipoprotein particle remodeling (GO:0034369)3.23157309
100positive regulation of Cdc42 GTPase activity (GO:0043089)3.22105318
101vitamin A metabolic process (GO:0006776)3.21016499
102water homeostasis (GO:0030104)3.16884377
103bile acid metabolic process (GO:0008206)3.16715956
104high-density lipoprotein particle remodeling (GO:0034375)3.15453567
105adhesion of symbiont to host (GO:0044406)3.15190971
106fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.14478515
107glomerular filtration (GO:0003094)3.12622950
108dopamine receptor signaling pathway (GO:0007212)3.12236524
109synaptic vesicle exocytosis (GO:0016079)3.10821888
110regulation of vitamin metabolic process (GO:0030656)3.10810894
111homocysteine metabolic process (GO:0050667)3.10504739
112retinoic acid metabolic process (GO:0042573)3.10153324
113plasma lipoprotein particle organization (GO:0071827)3.09421530
114membrane hyperpolarization (GO:0060081)3.08572842
115drug transport (GO:0015893)3.05539163
116antigen processing and presentation via MHC class Ib (GO:0002475)3.05283892
117glutamate secretion (GO:0014047)3.05099655
118transcytosis (GO:0045056)3.04621684
119glycolipid catabolic process (GO:0019377)3.03783061
120synaptic vesicle maturation (GO:0016188)3.03639973
121positive regulation of glycoprotein biosynthetic process (GO:0010560)3.03086505
122regulation of pseudopodium assembly (GO:0031272)3.02421313
123glycosphingolipid catabolic process (GO:0046479)3.00949493
124auditory receptor cell differentiation (GO:0042491)3.00702660
125complement activation, alternative pathway (GO:0006957)2.99468620
126* O-glycan processing (GO:0016266)2.96851096
127calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.96777840
128negative regulation of hormone metabolic process (GO:0032351)2.96516602
129negative regulation of hormone biosynthetic process (GO:0032353)2.96516602
130protein-lipid complex subunit organization (GO:0071825)2.96214718
131long-term synaptic potentiation (GO:0060291)2.95104375
132regulation of keratinocyte proliferation (GO:0010837)2.94757156
133renal filtration (GO:0097205)2.92133680
134positive regulation of cGMP biosynthetic process (GO:0030828)2.92073447
135regulation of female receptivity (GO:0045924)2.91847550
136cellular response to reactive nitrogen species (GO:1902170)2.90824276
137drug transmembrane transport (GO:0006855)2.90543616
138negative regulation of protein activation cascade (GO:2000258)2.90234506
139cellular response to nitric oxide (GO:0071732)2.89805845
140synaptic transmission, glutamatergic (GO:0035249)2.89476754
141positive regulation of respiratory burst (GO:0060267)2.88963446
142vitamin transport (GO:0051180)2.87432103
143epithelial structure maintenance (GO:0010669)2.86858172
144glutamine family amino acid biosynthetic process (GO:0009084)2.86399602
145complement activation (GO:0006956)2.85984019
146omega-hydroxylase P450 pathway (GO:0097267)2.85696182
147female mating behavior (GO:0060180)2.84706680
148regulation of guanylate cyclase activity (GO:0031282)2.81416431
149receptor recycling (GO:0001881)2.80811992
150regulation of heart rate by cardiac conduction (GO:0086091)2.80178153
151adenosine receptor signaling pathway (GO:0001973)2.80110802
152positive regulation of CREB transcription factor activity (GO:0032793)2.79039681
153neuron-neuron synaptic transmission (GO:0007270)2.78180064
154cell communication involved in cardiac conduction (GO:0086065)2.76397384
155cellular potassium ion homeostasis (GO:0030007)2.75906388
156positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.75638442
157sialylation (GO:0097503)2.74784249
158neurotransmitter-gated ion channel clustering (GO:0072578)2.74541090
159regulation of long-term neuronal synaptic plasticity (GO:0048169)2.73989173
160glutamate receptor signaling pathway (GO:0007215)2.73904632
161neurotransmitter secretion (GO:0007269)2.73508247
162positive regulation of guanylate cyclase activity (GO:0031284)2.73312468
163neuronal action potential propagation (GO:0019227)2.73272428
164cardiovascular system development (GO:0072358)2.70410338
165atrioventricular valve morphogenesis (GO:0003181)2.69549932
166intestinal epithelial cell development (GO:0060576)2.67850543
167purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.66633753
1683-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.66633753
169UDP-N-acetylglucosamine metabolic process (GO:0006047)2.66334801
170sulfate transport (GO:0008272)2.65923232
171valine metabolic process (GO:0006573)2.64117334
172behavioral response to pain (GO:0048266)2.63029225
173regulation of neuronal synaptic plasticity (GO:0048168)2.62237363
174retinol metabolic process (GO:0042572)2.60184325
175negative regulation of receptor activity (GO:2000272)2.59374144
176positive regulation of neurotransmitter secretion (GO:0001956)2.58747887
177bicarbonate transport (GO:0015701)2.56177950
178vitamin transmembrane transport (GO:0035461)2.54812540
179cytoskeletal anchoring at plasma membrane (GO:0007016)2.54466329
180membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.53765052
181regulation of excitatory postsynaptic membrane potential (GO:0060079)2.52538748
182regulation of sodium ion transport (GO:0002028)2.51827197
183desmosome organization (GO:0002934)2.50176656
184negative regulation of humoral immune response (GO:0002921)2.49968530
185neurotransmitter catabolic process (GO:0042135)2.49863027
186regulation of synaptic plasticity (GO:0048167)2.48914393
187establishment of skin barrier (GO:0061436)2.47800305
188negative regulation of epidermal cell differentiation (GO:0045605)2.47555159

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.82973311
2EZH2_22144423_ChIP-Seq_EOC_Human3.27395937
3DROSHA_22980978_ChIP-Seq_HELA_Human2.89116044
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.86945525
5IKZF1_21737484_ChIP-ChIP_HCT116_Human2.79667086
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74065621
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.62234876
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.57252196
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.38695939
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37031747
11GBX2_23144817_ChIP-Seq_PC3_Human2.36918477
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.35188443
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.32333678
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23474671
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23474671
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.21226452
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19598941
18LXR_22292898_ChIP-Seq_THP-1_Human2.14395165
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.12863400
20CDX2_20551321_ChIP-Seq_CACO-2_Human2.11408120
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.11139344
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.10079572
23JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06048796
24CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05389874
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.02792394
26EGR1_23403033_ChIP-Seq_LIVER_Mouse2.02606575
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.02017471
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01104805
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.00748042
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97610493
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.96522519
32REST_21632747_ChIP-Seq_MESCs_Mouse1.92471200
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90374385
34TP53_16413492_ChIP-PET_HCT116_Human1.89254577
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.88422781
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84517027
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84412001
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.82063345
39RXR_22108803_ChIP-Seq_LS180_Human1.79957267
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.78846099
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.74293222
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.71848470
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.70138824
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.69651796
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.68895556
46GATA1_26923725_Chip-Seq_HPCs_Mouse1.67712623
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66301221
48RACK7_27058665_Chip-Seq_MCF-7_Human1.65741248
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.64748792
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.64289182
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62116635
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.59295045
53SOX2_27498859_Chip-Seq_STOMACH_Mouse1.57777204
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.57332220
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55784399
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55142242
57NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.52915849
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48855906
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47372719
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.46344644
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.43442517
62SOX2_20726797_ChIP-Seq_SW620_Human1.42710665
63FOXA2_19822575_ChIP-Seq_HepG2_Human1.35964928
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34920050
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32236204
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29653839
67GATA1_22025678_ChIP-Seq_K562_Human1.26060843
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25386352
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25102285
70HNF4A_19822575_ChIP-Seq_HepG2_Human1.25093149
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24123522
72BCOR_27268052_Chip-Seq_Bcells_Human1.23722241
73BCL6_27268052_Chip-Seq_Bcells_Human1.21087658
74BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.20848802
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.19786017
76AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18455744
77P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17481347
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16550625
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16528826
80SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16231442
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15797568
82REST_18959480_ChIP-ChIP_MESCs_Mouse1.15266344
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14276949
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13624627
85SA1_27219007_Chip-Seq_Bcells_Human1.13226560
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12969331
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12969331
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11754195
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11500322
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11003287
91CREB1_26743006_Chip-Seq_LNCaP_Human1.10939568
92AHR_22903824_ChIP-Seq_MCF-7_Human1.09761463
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09706313
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08077375
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.07942517
96CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07788971
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.07519879
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07490424
99JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.04816362
100TP63_22573176_ChIP-Seq_HFKS_Human1.03675250
101CLOCK_20551151_ChIP-Seq_293T_Human1.03386848
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.03026151
103SMC4_20622854_ChIP-Seq_HELA_Human1.02333792
104ESR2_21235772_ChIP-Seq_MCF-7_Human1.02273526
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.02083362
106P68_20966046_ChIP-Seq_HELA_Human1.01467175
107CTCF_27219007_Chip-Seq_Bcells_Human1.00004660
108KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99942105
109ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99000529
110P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98983759
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98981132
112SMAD3_21741376_ChIP-Seq_EPCs_Human0.98516349
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97717882
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95818397
115FOXA1_25552417_ChIP-Seq_VCAP_Human0.94747110
116SMAD4_21799915_ChIP-Seq_A2780_Human0.94352938
117GATA1_19941826_ChIP-Seq_K562_Human0.94113157
118PHF8_20622854_ChIP-Seq_HELA_Human0.93830212
119E2F1_20622854_ChIP-Seq_HELA_Human0.93420429
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92172965
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92132057
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.91541727
123TAF15_26573619_Chip-Seq_HEK293_Human0.90986602
124RUNX1_27514584_Chip-Seq_MCF-7_Human0.90930594
125AR_19668381_ChIP-Seq_PC3_Human0.90517846
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90277829
127RING1B_27294783_Chip-Seq_ESCs_Mouse0.90032422
128P300_19829295_ChIP-Seq_ESCs_Human0.89854263
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89603787
130RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88354458
131RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88278644
132GATA2_19941826_ChIP-Seq_K562_Human0.87631151
133TCF7_22412390_ChIP-Seq_EML_Mouse0.86958137
134AR_21572438_ChIP-Seq_LNCaP_Human0.86737031
135CTCF_20526341_ChIP-Seq_ESCs_Human0.86398552
136TP53_18474530_ChIP-ChIP_U2OS_Human0.85792939
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85373289
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84600318
139SOX2_21211035_ChIP-Seq_LN229_Gbm0.83976754
140CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83088338
141NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83028096
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83028096
143NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82519755
144RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.82469791
145MYC_27129775_Chip-Seq_CORNEA_Mouse0.82446532
146PRDM14_20953172_ChIP-Seq_ESCs_Human0.81796586
147CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81108271
148TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81079318
149PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.80712481
150NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80707416
151EP300_21415370_ChIP-Seq_HL-1_Mouse0.80668881
152SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80558631
153CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79895063
154BCAT_22108803_ChIP-Seq_LS180_Human0.79741666
155KDM2B_26808549_Chip-Seq_K562_Human0.79509169
156KLF4_19829295_ChIP-Seq_ESCs_Human0.79384537
157TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.79230115
158PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.79125863
159STAT3_23295773_ChIP-Seq_U87_Human0.78834482
160GATA6_25053715_ChIP-Seq_YYC3_Human0.78827652
161AR_25329375_ChIP-Seq_VCAP_Human0.78558924
162CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78462014
163NANOG_20526341_ChIP-Seq_ESCs_Human0.78450891
164EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78061181
165EGR1_19032775_ChIP-ChIP_M12_Human0.77937423
166SA1_27219007_Chip-Seq_ERYTHROID_Human0.77716674
167KLF5_25053715_ChIP-Seq_YYC3_Human0.77467894
168GATA4_25053715_ChIP-Seq_YYC3_Human0.77450088
169CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76896842
170* SMAD4_21741376_ChIP-Seq_HESCs_Human0.76888502
171TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.76254106
172NANOG_18555785_Chip-Seq_ESCs_Mouse0.76044101
173SUZ12_18555785_Chip-Seq_ESCs_Mouse0.75755954

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.87549320
2MP0002822_catalepsy4.22716093
3MP0004859_abnormal_synaptic_plasticity4.15236903
4MP0008875_abnormal_xenobiotic_pharmacok3.89903749
5MP0005365_abnormal_bile_salt3.59717855
6MP0009840_abnormal_foam_cell3.34383574
7MP0004264_abnormal_extraembryonic_tissu3.16200281
8MP0004019_abnormal_vitamin_homeostasis3.08063579
9MP0010234_abnormal_vibrissa_follicle3.02900226
10MP0005409_darkened_coat_color2.83074345
11MP0002254_reproductive_system_inflammat2.76499552
12MP0003866_abnormal_defecation2.68703637
13MP0003635_abnormal_synaptic_transmissio2.60985503
14MP0003880_abnormal_central_pattern2.50547991
15MP0001501_abnormal_sleep_pattern2.50224451
16MP0004043_abnormal_pH_regulation2.45956674
17MP0009745_abnormal_behavioral_response2.45892574
18MP0005670_abnormal_white_adipose2.43999428
19MP0001968_abnormal_touch/_nociception2.42842024
20MP0009379_abnormal_foot_pigmentation2.31271629
21MP0009780_abnormal_chondrocyte_physiolo2.28336547
22MP0001188_hyperpigmentation2.28163984
23MP0010329_abnormal_lipoprotein_level2.20857059
24MP0003879_abnormal_hair_cell2.18666375
25MP0002272_abnormal_nervous_system2.08384570
26MP0003172_abnormal_lysosome_physiology2.06297403
27MP0002064_seizures2.06022146
28MP0001486_abnormal_startle_reflex2.00295768
29MP0001440_abnormal_grooming_behavior1.99273334
30MP0002063_abnormal_learning/memory/cond1.96996024
31MP0005646_abnormal_pituitary_gland1.91752234
32MP0005332_abnormal_amino_acid1.91245334
33MP0004270_analgesia1.89777457
34MP0001664_abnormal_digestion1.87830458
35MP0002876_abnormal_thyroid_physiology1.86960144
36MP0002572_abnormal_emotion/affect_behav1.86492372
37MP0001873_stomach_inflammation1.85116032
38MP0010352_gastrointestinal_tract_polyps1.83689826
39MP0009046_muscle_twitch1.82517780
40MP0001663_abnormal_digestive_system1.82476627
41MP0005310_abnormal_salivary_gland1.79919041
42MP0002138_abnormal_hepatobiliary_system1.78231556
43MP0003283_abnormal_digestive_organ1.75672165
44MP0009643_abnormal_urine_homeostasis1.74664514
45MP0002734_abnormal_mechanical_nocicepti1.68935117
46MP0010155_abnormal_intestine_physiology1.67296079
47MP0002733_abnormal_thermal_nociception1.65081252
48MP0008569_lethality_at_weaning1.63762361
49MP0003252_abnormal_bile_duct1.62108384
50MP0008872_abnormal_physiological_respon1.61955689
51MP0001970_abnormal_pain_threshold1.60166233
52MP0005381_digestive/alimentary_phenotyp1.57630776
53MP0001666_abnormal_nutrient_absorption1.56405570
54MP0000462_abnormal_digestive_system1.51351488
55MP0002736_abnormal_nociception_after1.51265574
56MP0000538_abnormal_urinary_bladder1.50588682
57MP0003828_pulmonary_edema1.47706752
58MP0001346_abnormal_lacrimal_gland1.44706078
59MP0001765_abnormal_ion_homeostasis1.37425552
60MP0005451_abnormal_body_composition1.34895587
61MP0004742_abnormal_vestibular_system1.32991373
62MP0005167_abnormal_blood-brain_barrier1.30790373
63MP0002118_abnormal_lipid_homeostasis1.27301628
64MP0003183_abnormal_peptide_metabolism1.25800890
65MP0001764_abnormal_homeostasis1.24022425
66MP0003878_abnormal_ear_physiology1.21896392
67MP0005377_hearing/vestibular/ear_phenot1.21896392
68MP0005085_abnormal_gallbladder_physiolo1.21575652
69MP0002136_abnormal_kidney_physiology1.20260967
70MP0005174_abnormal_tail_pigmentation1.18680551
71MP0004782_abnormal_surfactant_physiolog1.17531086
72MP0001485_abnormal_pinna_reflex1.17092794
73MP0003300_gastrointestinal_ulcer1.16911956
74MP0002557_abnormal_social/conspecific_i1.16092423
75MP0002277_abnormal_respiratory_mucosa1.15943451
76MP0004484_altered_response_of1.13919899
77MP0003633_abnormal_nervous_system1.10964415
78MP0000678_abnormal_parathyroid_gland1.09260484
79MP0002735_abnormal_chemical_nociception1.08380038
80MP0008004_abnormal_stomach_pH1.07656206
81MP0005448_abnormal_energy_balance1.06554553
82MP0002067_abnormal_sensory_capabilities1.06117729
83MP0001756_abnormal_urination1.04858155
84MP0004924_abnormal_behavior1.04097249
85MP0005386_behavior/neurological_phenoty1.04097249
86MP0002098_abnormal_vibrissa_morphology1.02691804
87MP0005423_abnormal_somatic_nervous1.02522965
88MP0000609_abnormal_liver_physiology1.01370613
89MP0005360_urolithiasis1.00493824
90MP0000230_abnormal_systemic_arterial0.96232607
91MP0005166_decreased_susceptibility_to0.96037632
92MP0002132_abnormal_respiratory_system0.95686166
93MP0008874_decreased_physiological_sensi0.94101983
94MP0002971_abnormal_brown_adipose0.93791808
95MP0010678_abnormal_skin_adnexa0.93510011
96MP0005666_abnormal_adipose_tissue0.92322804
97MP0001849_ear_inflammation0.90580209
98MP0003868_abnormal_feces_composition0.89615484
99MP0009115_abnormal_fat_cell0.89365293
100MP0003718_maternal_effect0.89063759
101MP0003075_altered_response_to0.88256936
102MP0009278_abnormal_bone_marrow0.87329509
103MP0005535_abnormal_body_temperature0.86788117
104MP0000537_abnormal_urethra_morphology0.86467027
105MP0002909_abnormal_adrenal_gland0.85852909
106MP0003806_abnormal_nucleotide_metabolis0.83040865
107MP0009764_decreased_sensitivity_to0.82639361
108MP0000477_abnormal_intestine_morphology0.81092454
109MP0005319_abnormal_enzyme/_coenzyme0.79237197
110MP0005584_abnormal_enzyme/coenzyme_acti0.76881139
111MP0002066_abnormal_motor_capabilities/c0.74908286
112MP0001963_abnormal_hearing_physiology0.74560480
113MP0000465_gastrointestinal_hemorrhage0.73912441
114MP0004147_increased_porphyrin_level0.73635086
115MP0000249_abnormal_blood_vessel0.72566845
116MP0009765_abnormal_xenobiotic_induced0.72492351
117MP0002249_abnormal_larynx_morphology0.72138519
118MP0000470_abnormal_stomach_morphology0.71792644
119MP0005645_abnormal_hypothalamus_physiol0.71047604
120MP0003191_abnormal_cellular_cholesterol0.70317406
121MP0004885_abnormal_endolymph0.70032697
122MP0008961_abnormal_basal_metabolism0.69795639
123MP0009642_abnormal_blood_homeostasis0.69569568
124MP0001845_abnormal_inflammatory_respons0.69389362
125MP0000778_abnormal_nervous_system0.68649039
126MP0004858_abnormal_nervous_system0.68541640
127MP0000490_abnormal_crypts_of0.68330935
128MP0003195_calcinosis0.67304202
129MP0005636_abnormal_mineral_homeostasis0.67202792
130MP0006138_congestive_heart_failure0.64809153
131MP0000566_synostosis0.64390872
132MP0002234_abnormal_pharynx_morphology0.64008384
133MP0004947_skin_inflammation0.63974558
134MP0004811_abnormal_neuron_physiology0.63581210
135MP0003631_nervous_system_phenotype0.63443863
136MP0002796_impaired_skin_barrier0.63395352
137MP0000613_abnormal_salivary_gland0.62958238
138MP0004510_myositis0.61607429
139MP0005058_abnormal_lysosome_morphology0.61529202
140MP0002069_abnormal_eating/drinking_beha0.61217767
141MP0002896_abnormal_bone_mineralization0.60937430
142MP0003787_abnormal_imprinting0.60171876
143MP0003705_abnormal_hypodermis_morpholog0.59073195
144MP0002078_abnormal_glucose_homeostasis0.59051134
145MP0000467_abnormal_esophagus_morphology0.58984643
146MP0008469_abnormal_protein_level0.58526969
147MP0003638_abnormal_response/metabolism_0.56867115
148MP0005501_abnormal_skin_physiology0.56645323
149MP0003953_abnormal_hormone_level0.53029513
150MP0002998_abnormal_bone_remodeling0.52005344
151MP0002166_altered_tumor_susceptibility0.51377286
152MP0009785_altered_susceptibility_to0.50566377
153MP0003045_fibrosis0.49707420
154MP0005334_abnormal_fat_pad0.48895401
155MP0002089_abnormal_postnatal_growth/wei0.47807482
156MP0005375_adipose_tissue_phenotype0.47318440
157MP0005025_abnormal_response_to0.46296396
158MP0005395_other_phenotype0.45684048
159MP0003436_decreased_susceptibility_to0.43157199
160MP0000604_amyloidosis0.43011292
161MP0005023_abnormal_wound_healing0.41309139

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)9.32973549
2Malnutrition (HP:0004395)6.85526508
3Hydroxyprolinuria (HP:0003080)6.60641888
4Abnormality of proline metabolism (HP:0010907)6.60641888
5Hyperactive renin-angiotensin system (HP:0000841)6.43257179
6Scanning speech (HP:0002168)6.34831813
7Metabolic alkalosis (HP:0200114)6.19621274
8Myokymia (HP:0002411)4.91559674
9Systemic lupus erythematosus (HP:0002725)4.90387993
10Focal motor seizures (HP:0011153)4.55324452
11Hypobetalipoproteinemia (HP:0003563)4.41963065
12Pustule (HP:0200039)4.39321169
13Abnormality of monocarboxylic acid metabolism (HP:0010996)4.38092891
14Abnormality of renin-angiotensin system (HP:0000847)4.33038208
15Right ventricular cardiomyopathy (HP:0011663)4.30465632
16Increased circulating renin level (HP:0000848)4.15862396
17Esophageal atresia (HP:0002032)4.12647167
18Distal lower limb muscle weakness (HP:0009053)4.07847034
19Fat malabsorption (HP:0002630)3.97005055
20Widely patent fontanelles and sutures (HP:0004492)3.95511415
21Abnormality of chloride homeostasis (HP:0011422)3.90694753
22Hemorrhage of the eye (HP:0011885)3.85995129
23Thin bony cortex (HP:0002753)3.82994655
24Hyperaldosteronism (HP:0000859)3.77603264
25Hyperglycinuria (HP:0003108)3.69165752
26Confusion (HP:0001289)3.63946027
27Syncope (HP:0001279)3.61382946
28Xanthomatosis (HP:0000991)3.60744125
29Complement deficiency (HP:0004431)3.58943928
30Abnormality of binocular vision (HP:0011514)3.49180020
31Diplopia (HP:0000651)3.49180020
32Congenital sensorineural hearing impairment (HP:0008527)3.48970751
33Proximal tubulopathy (HP:0000114)3.41013854
34Ileus (HP:0002595)3.34941700
35Abnormality of complement system (HP:0005339)3.33796499
36Prolonged QT interval (HP:0001657)3.30430267
37Decreased circulating renin level (HP:0003351)3.24478319
38Epileptic encephalopathy (HP:0200134)3.19537097
39Abnormality of glycine metabolism (HP:0010895)3.19406670
40Abnormality of serine family amino acid metabolism (HP:0010894)3.19406670
41Large eyes (HP:0001090)3.17716656
42Bundle branch block (HP:0011710)3.14769474
43Potter facies (HP:0002009)3.07041569
44Facial shape deformation (HP:0011334)3.07041569
45Acanthocytosis (HP:0001927)3.04875627
46Chronic diarrhea (HP:0002028)3.03548585
47Pigmentary retinal degeneration (HP:0001146)3.02405051
48Glomerulonephritis (HP:0000099)3.02264074
49Poor eye contact (HP:0000817)3.01181403
50Wide cranial sutures (HP:0010537)3.00017523
51Focal seizures (HP:0007359)2.99579703
52Focal segmental glomerulosclerosis (HP:0000097)2.97429518
53Tetany (HP:0001281)2.94804256
54Nephrolithiasis (HP:0000787)2.93102630
55Ventricular fibrillation (HP:0001663)2.92678957
56Increased neuronal autofluorescent lipopigment (HP:0002074)2.91749405
57Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.90298361
58Increased purine levels (HP:0004368)2.84804209
59Hyperuricemia (HP:0002149)2.84804209
60Abnormal social behavior (HP:0012433)2.82570592
61Impaired social interactions (HP:0000735)2.82570592
62Hypophosphatemia (HP:0002148)2.78433975
63Progressive visual loss (HP:0000529)2.77741476
64Abnormal EKG (HP:0003115)2.71110391
65Febrile seizures (HP:0002373)2.69546551
66Clumsiness (HP:0002312)2.65864954
67Abnormality of urine glucose concentration (HP:0011016)2.65266037
68Glycosuria (HP:0003076)2.65266037
69Nephritis (HP:0000123)2.63982419
70Increased cerebral lipofuscin (HP:0011813)2.63473769
71Nausea (HP:0002018)2.63373430
72Abnormality of magnesium homeostasis (HP:0004921)2.63094833
73Alkalosis (HP:0001948)2.62414019
74Abnormality of the vitamin B12 metabolism (HP:0004341)2.61346766
75Cerebral palsy (HP:0100021)2.57446971
76Gaze-evoked nystagmus (HP:0000640)2.54734874
77Progressive cerebellar ataxia (HP:0002073)2.51585920
78Steatorrhea (HP:0002570)2.50443890
79Hypokalemia (HP:0002900)2.49690730
80Abnormality of DNA repair (HP:0003254)2.45850569
81Gout (HP:0001997)2.44699522
82Villous atrophy (HP:0011473)2.43616276
83Abnormality of small intestinal villus morphology (HP:0011472)2.43616276
84Hypolipoproteinemia (HP:0010981)2.43499533
85Short chin (HP:0000331)2.43035367
86Abnormality of pyrimidine metabolism (HP:0004353)2.41856371
87Intention tremor (HP:0002080)2.41426437
88Action tremor (HP:0002345)2.40606486
89Visual hallucinations (HP:0002367)2.40552394
90Abnormality of vitamin B metabolism (HP:0004340)2.39289267
91Abnormality of nucleobase metabolism (HP:0010932)2.39108172
92Alopecia of scalp (HP:0002293)2.37913272
93Abnormality of purine metabolism (HP:0004352)2.37848581
94Abnormal drinking behavior (HP:0030082)2.36811285
95Polydipsia (HP:0001959)2.36811285
96Progressive hearing impairment (HP:0001730)2.33605033
97Adrenal overactivity (HP:0002717)2.32593006
98Impaired platelet aggregation (HP:0003540)2.29491162
99Abnormal platelet function (HP:0011869)2.29491162
100Flat acetabular roof (HP:0003180)2.28658808
101Hyperammonemia (HP:0001987)2.27586880
102Abnormality of the 1st metacarpal (HP:0010009)2.27043962
103Atonic seizures (HP:0010819)2.26434771
104Protuberant abdomen (HP:0001538)2.26388107
105Broad-based gait (HP:0002136)2.26178709
106Intrahepatic cholestasis (HP:0001406)2.25682752
107Hypotension (HP:0002615)2.25500037
108Glomerulosclerosis (HP:0000096)2.25134354
109Hyperparathyroidism (HP:0000843)2.24260937
110Abdominal distention (HP:0003270)2.23098806
111Gastrointestinal atresia (HP:0002589)2.21798450
112Upper motor neuron abnormality (HP:0002127)2.17960967
113Gastrointestinal dysmotility (HP:0002579)2.17887869
114Hypokalemic alkalosis (HP:0001949)2.15193886
115Axonal loss (HP:0003447)2.14256751
116Ventricular arrhythmia (HP:0004308)2.13602901
117Heart block (HP:0012722)2.13219631
118Eczematoid dermatitis (HP:0000976)2.10958188
119Abnormal atrioventricular conduction (HP:0005150)2.10893040
120Conjugated hyperbilirubinemia (HP:0002908)2.10181870
121Dysmetria (HP:0001310)2.09095421
122Neonatal short-limb short stature (HP:0008921)2.07535447
123Hypomagnesemia (HP:0002917)2.06099537
124Dysdiadochokinesis (HP:0002075)2.04073898
125Postural tremor (HP:0002174)2.03713251
126Abnormality of potassium homeostasis (HP:0011042)2.01961214
127Anxiety (HP:0000739)2.00934568
128Symphalangism affecting the phalanges of the hand (HP:0009773)2.00272150
129Genetic anticipation (HP:0003743)1.99960291
130Lower limb amyotrophy (HP:0007210)1.99354440
131Gingivitis (HP:0000230)1.98995418
132Relative macrocephaly (HP:0004482)1.98914730
133Decreased subcutaneous fat (HP:0001002)1.98208994
134Hypoplasia of dental enamel (HP:0006297)1.97878090
135Late onset (HP:0003584)1.97822732
136Pancreatitis (HP:0001733)1.97735272
137Enlarged epiphyses (HP:0010580)1.97632104
138Megaloblastic anemia (HP:0001889)1.96546213
139Cheilitis (HP:0100825)1.95261436
140Dehydration (HP:0001944)1.94301692
141Abnormality of the preputium (HP:0100587)1.93297547
142Abnormal urine phosphate concentration (HP:0012599)1.92675346
143Symptomatic seizures (HP:0011145)1.89286647
144Distal lower limb amyotrophy (HP:0008944)1.87911759
145Segmental peripheral demyelination/remyelination (HP:0003481)1.87798539
146Metabolic acidosis (HP:0001942)1.86916790
147Hyperphosphatemia (HP:0002905)1.86845752
148Optic neuritis (HP:0100653)1.86444367
149Retrobulbar optic neuritis (HP:0100654)1.86444367
150Keratoconjunctivitis (HP:0001096)1.86178578
151Methylmalonic acidemia (HP:0002912)1.85869255
152Xerostomia (HP:0000217)1.85169899
153Abnormal glucose tolerance (HP:0001952)1.84849120
154Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84491701
155Dicarboxylic aciduria (HP:0003215)1.84491701
156Broad metatarsal (HP:0001783)1.84290073
157Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.84057870
158Ankyloglossia (HP:0010296)1.83802429
159Bronchomalacia (HP:0002780)1.83214773
160Abnormality of the corticospinal tract (HP:0002492)1.82298352
161Rectal prolapse (HP:0002035)1.81516911
162Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80653981
163Pili torti (HP:0003777)1.80138942
164Delayed epiphyseal ossification (HP:0002663)1.79741092
165Hyperventilation (HP:0002883)1.79709848
166Onycholysis (HP:0001806)1.78936659
167Plantar hyperkeratosis (HP:0007556)1.77730198
168Abnormality of vitamin metabolism (HP:0100508)1.77386978
169Mildly elevated creatine phosphokinase (HP:0008180)1.76527865
170Posterior subcapsular cataract (HP:0007787)1.73872079
171Abnormal hair laboratory examination (HP:0003328)1.71664154
172Abnormality of alkaline phosphatase activity (HP:0004379)1.68142208
173Myopathic facies (HP:0002058)1.65530274
174Abnormal enzyme/coenzyme activity (HP:0012379)1.65091988
175Emphysema (HP:0002097)1.64982514
176Subcapsular cataract (HP:0000523)1.63462872

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK37.52282771
2ACVR1B5.66625756
3SIK24.98786553
4ERN14.35147056
5SIK13.96443038
6EPHA23.76393164
7MST43.55223628
8ADRBK23.05593978
9MET2.90091824
10NTRK32.90016370
11TAOK32.78336970
12TYRO32.64851430
13EPHA42.64426373
14TAOK12.45984804
15FGFR42.45281514
16MAP3K102.39674864
17MARK32.35947721
18KSR22.12991163
19EPHB22.05432864
20MAP3K92.04004058
21LMTK21.91940698
22SGK31.91771943
23TRIB31.80478213
24RIPK41.72175448
25DDR21.70238052
26EPHB11.61796007
27TNIK1.60704525
28STK391.52598894
29MAP3K121.37734916
30EPHA31.29694875
31NME11.28854453
32TYK21.20978251
33MAP3K131.19504486
34ERBB21.19314933
35KSR11.15884702
36MAP4K11.15771544
37CDK121.14599147
38PRKG21.14429013
39DAPK21.13715078
40SGK21.12186265
41ICK1.08941012
42PIK3CA1.08917578
43SGK2231.04768582
44SGK4941.04768582
45MARK21.00616099
46MST1R1.00195621
47CASK0.97599004
48FGFR30.97138545
49TAOK20.95371515
50PRKAA20.93558470
51CDK190.90882260
52MAP2K20.89228510
53PDK30.88790568
54PDK40.88790568
55NLK0.87624396
56PDGFRA0.87359634
57AKT30.86880053
58PRPF4B0.85446278
59PAK60.84710019
60TESK20.82503857
61FRK0.81118698
62CDC42BPA0.78369694
63MAP3K70.78130061
64MAP2K70.77611507
65PTK20.75993968
66BMX0.75782508
67STK240.74565975
68MAP3K10.72256033
69GRK60.72039895
70MAP3K20.70417441
71MINK10.69710070
72MAP2K60.68401099
73MAPK110.68265115
74BMPR20.67566884
75DMPK0.64018661
76CDK50.63392403
77MYLK0.63067822
78TNK20.62610696
79CAMK2B0.61815562
80CAMK10.61760626
81ADRBK10.60553613
82SMG10.59327086
83CAMK2A0.59281369
84OXSR10.57417512
85MAP3K40.57243431
86PAK30.57107187
87RPS6KA20.55360478
88TESK10.54784711
89MAP2K10.53717073
90PRKACG0.53242725
91EEF2K0.52066200
92MAP3K110.51812870
93CAMK2D0.51050956
94CAMKK10.50761209
95PDPK10.50711192
96SGK10.48563212
97PDK10.48089849
98PAK40.47935323
99ZAP700.46377696
100TBK10.46144961
101PRKCG0.46108904
102PKN20.45877880
103DAPK10.44996220
104CAMK2G0.44510909
105PDK20.43958584
106MAP2K40.42495170
107RET0.41419767
108RIPK10.41174697
109RAF10.40683391
110NEK60.40535335
111MAPKAPK50.40282517
112RPS6KB20.39426661
113PRKCZ0.39317691
114WNK10.39215237
115MAPK70.38741226
116DYRK1B0.36491330
117MELK0.36373006
118PRKCI0.36247109
119RPS6KC10.36205600
120RPS6KL10.36205600
121PRKCE0.35972400
122STK100.34871064
123TXK0.34396770
124KDR0.33886825
125RPS6KA60.33596025
126HIPK20.33207412
127MTOR0.33115050
128MATK0.32935120
129STK380.32769558
130MAP3K60.32186047
131FES0.31239967
132PRKCA0.30722606
133PRKD20.30571519
134CSF1R0.30562971
135PRKAA10.30304088
136GRK10.29992564
137TEC0.28976164
138CSNK1A10.28711486
139IRAK10.27964724
140STK110.27862068
141IKBKE0.27833845
142NTRK20.27527176
143ALK0.27084125
144FYN0.26882961
145KIT0.26545847
146MAPKAPK20.26158053
147PDGFRB0.25896624
148SRC0.25490806
149PRKCH0.25214460
150MAP3K30.24801040
151CHUK0.23950819
152PRKD30.23875610
153MAP2K30.23809943
154MAPK130.23416465
155AKT20.22694927
156FER0.20977236
157INSRR0.20917351
158JAK10.20868846
159PTK60.19454005
160PRKCQ0.19446028

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.00590746
2Sulfur metabolism_Homo sapiens_hsa009203.73907729
3Nicotine addiction_Homo sapiens_hsa050332.51090352
4Tyrosine metabolism_Homo sapiens_hsa003502.46467418
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.32479958
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.28512178
7Caffeine metabolism_Homo sapiens_hsa002322.25028504
8Gastric acid secretion_Homo sapiens_hsa049712.11060477
9Starch and sucrose metabolism_Homo sapiens_hsa005002.10890094
10Fructose and mannose metabolism_Homo sapiens_hsa000512.09725970
11Histidine metabolism_Homo sapiens_hsa003402.03544408
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02565168
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.01893706
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.00550315
15Mineral absorption_Homo sapiens_hsa049782.00356428
16Circadian entrainment_Homo sapiens_hsa047132.00266123
17Salivary secretion_Homo sapiens_hsa049701.99265306
18Morphine addiction_Homo sapiens_hsa050321.91330817
19Amphetamine addiction_Homo sapiens_hsa050311.88436209
20Synaptic vesicle cycle_Homo sapiens_hsa047211.86537876
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.86249263
22Phenylalanine metabolism_Homo sapiens_hsa003601.84758226
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.83485559
24Chemical carcinogenesis_Homo sapiens_hsa052041.82458185
25Olfactory transduction_Homo sapiens_hsa047401.80027976
26Long-term potentiation_Homo sapiens_hsa047201.75041559
27PPAR signaling pathway_Homo sapiens_hsa033201.74219387
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.68300630
29Glutamatergic synapse_Homo sapiens_hsa047241.65219690
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.60602584
31Galactose metabolism_Homo sapiens_hsa000521.57858059
32Insulin secretion_Homo sapiens_hsa049111.51919730
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.45784831
34Arginine and proline metabolism_Homo sapiens_hsa003301.44369720
35Arachidonic acid metabolism_Homo sapiens_hsa005901.43799091
36Long-term depression_Homo sapiens_hsa047301.42701034
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.41601114
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41517888
39Cholinergic synapse_Homo sapiens_hsa047251.41261814
40GABAergic synapse_Homo sapiens_hsa047271.41224660
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.40270042
42Taste transduction_Homo sapiens_hsa047421.39893172
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37743256
44Renin secretion_Homo sapiens_hsa049241.27260880
45Pancreatic secretion_Homo sapiens_hsa049721.26465672
46Tryptophan metabolism_Homo sapiens_hsa003801.26148599
47Dopaminergic synapse_Homo sapiens_hsa047281.25233888
48Cocaine addiction_Homo sapiens_hsa050301.25227643
49Calcium signaling pathway_Homo sapiens_hsa040201.23368962
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20674504
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19335631
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17321405
53Renin-angiotensin system_Homo sapiens_hsa046141.15260236
54Fatty acid degradation_Homo sapiens_hsa000711.14717483
55Fat digestion and absorption_Homo sapiens_hsa049751.14566763
56Bile secretion_Homo sapiens_hsa049761.13478844
57Serotonergic synapse_Homo sapiens_hsa047261.11165191
58Vibrio cholerae infection_Homo sapiens_hsa051101.11152558
59Retinol metabolism_Homo sapiens_hsa008301.07997033
60Nitrogen metabolism_Homo sapiens_hsa009101.04599383
61Cardiac muscle contraction_Homo sapiens_hsa042601.04101437
62GnRH signaling pathway_Homo sapiens_hsa049121.02192849
63beta-Alanine metabolism_Homo sapiens_hsa004101.02145018
64Oxytocin signaling pathway_Homo sapiens_hsa049211.00870058
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99309863
66Alzheimers disease_Homo sapiens_hsa050100.98394252
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97089848
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95000256
69Staphylococcus aureus infection_Homo sapiens_hsa051500.94642798
70Complement and coagulation cascades_Homo sapiens_hsa046100.93009435
71Oxidative phosphorylation_Homo sapiens_hsa001900.89475655
72Other glycan degradation_Homo sapiens_hsa005110.88907086
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87669847
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87185457
75Asthma_Homo sapiens_hsa053100.86428686
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.85782765
77Ether lipid metabolism_Homo sapiens_hsa005650.82067673
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.81979312
79African trypanosomiasis_Homo sapiens_hsa051430.79110995
80Type II diabetes mellitus_Homo sapiens_hsa049300.76579902
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76353178
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76044565
83ABC transporters_Homo sapiens_hsa020100.75397266
84cAMP signaling pathway_Homo sapiens_hsa040240.74010745
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.73652268
86Gap junction_Homo sapiens_hsa045400.70701190
87Collecting duct acid secretion_Homo sapiens_hsa049660.68358466
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.66215118
89Salmonella infection_Homo sapiens_hsa051320.64750120
90Glycerolipid metabolism_Homo sapiens_hsa005610.64620023
91Estrogen signaling pathway_Homo sapiens_hsa049150.63974300
92Tight junction_Homo sapiens_hsa045300.63513359
93ErbB signaling pathway_Homo sapiens_hsa040120.62222961
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61729769
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61415301
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61057911
97Parkinsons disease_Homo sapiens_hsa050120.60903586
98Glutathione metabolism_Homo sapiens_hsa004800.60510429
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58064168
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57524807
101Insulin resistance_Homo sapiens_hsa049310.57408627
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57304453
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56968083
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55422589
105Allograft rejection_Homo sapiens_hsa053300.53092880
106Thyroid hormone synthesis_Homo sapiens_hsa049180.50744694
107Graft-versus-host disease_Homo sapiens_hsa053320.50690034
108Autoimmune thyroid disease_Homo sapiens_hsa053200.49241606
109Arginine biosynthesis_Homo sapiens_hsa002200.48974156
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.48488603
111Sphingolipid metabolism_Homo sapiens_hsa006000.48249508
112Linoleic acid metabolism_Homo sapiens_hsa005910.45116633
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44760643
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44241530
115Fatty acid metabolism_Homo sapiens_hsa012120.44023506
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44018278
117Peroxisome_Homo sapiens_hsa041460.41485488
118Axon guidance_Homo sapiens_hsa043600.41279034
119Rap1 signaling pathway_Homo sapiens_hsa040150.38794494
120Glucagon signaling pathway_Homo sapiens_hsa049220.38743958
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.37920665
122Butanoate metabolism_Homo sapiens_hsa006500.36515069
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35493729
124Melanogenesis_Homo sapiens_hsa049160.34207945
125TNF signaling pathway_Homo sapiens_hsa046680.33048540
126MAPK signaling pathway_Homo sapiens_hsa040100.31677884
127Protein digestion and absorption_Homo sapiens_hsa049740.29944964
128Type I diabetes mellitus_Homo sapiens_hsa049400.29137576
129T cell receptor signaling pathway_Homo sapiens_hsa046600.28460390
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27522159
131Choline metabolism in cancer_Homo sapiens_hsa052310.27284841
132Glioma_Homo sapiens_hsa052140.26900427
133Hepatitis C_Homo sapiens_hsa051600.25541783
134Biosynthesis of amino acids_Homo sapiens_hsa012300.25509518
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25124430
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24672562
137Pertussis_Homo sapiens_hsa051330.24586184
138Fatty acid biosynthesis_Homo sapiens_hsa000610.23424253
139Vitamin digestion and absorption_Homo sapiens_hsa049770.23412662
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.23229747
141Ovarian steroidogenesis_Homo sapiens_hsa049130.22321656
142Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22300393
143Sulfur relay system_Homo sapiens_hsa041220.22145666
144Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20910232
145AMPK signaling pathway_Homo sapiens_hsa041520.20092445
146Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19079069
147Prion diseases_Homo sapiens_hsa050200.17380617
148Amoebiasis_Homo sapiens_hsa051460.15643704
149Antigen processing and presentation_Homo sapiens_hsa046120.14255481
150Pyruvate metabolism_Homo sapiens_hsa006200.14135858
151Carbon metabolism_Homo sapiens_hsa012000.12263095
152Metabolic pathways_Homo sapiens_hsa011000.12115551
153Notch signaling pathway_Homo sapiens_hsa043300.11799645
154Pentose phosphate pathway_Homo sapiens_hsa000300.11535543

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