MUC5AC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1diterpenoid biosynthetic process (GO:0016102)9.72115944
2axoneme assembly (GO:0035082)8.83869081
3glutathione derivative metabolic process (GO:1901685)8.47958323
4glutathione derivative biosynthetic process (GO:1901687)8.47958323
5ethanol metabolic process (GO:0006067)8.36552983
6digestive system process (GO:0022600)8.36267969
7left/right pattern formation (GO:0060972)8.15157218
8sulfation (GO:0051923)7.92300689
9response to iron ion (GO:0010039)7.90978377
10regulation of proton transport (GO:0010155)7.81827969
11vitamin transmembrane transport (GO:0035461)7.73814634
12protein autoprocessing (GO:0016540)7.71868464
13terpenoid biosynthetic process (GO:0016114)6.90571979
14bundle of His cell to Purkinje myocyte communication (GO:0086069)6.84511935
15retinoic acid metabolic process (GO:0042573)6.83958467
16negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)6.77645471
17regulation of cilium movement (GO:0003352)6.41938194
18pyrimidine-containing compound transmembrane transport (GO:0072531)6.37815546
19negative regulation of digestive system process (GO:0060457)6.37203103
203-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)6.33794196
21purine ribonucleoside bisphosphate metabolic process (GO:0034035)6.33794196
22glandular epithelial cell differentiation (GO:0002067)6.31078857
23one-carbon compound transport (GO:0019755)6.13844355
24regulation of phospholipase A2 activity (GO:0032429)6.06828417
25* O-glycan processing (GO:0016266)5.96522562
26kidney morphogenesis (GO:0060993)5.85359562
27microtubule bundle formation (GO:0001578)5.63850101
28retinol metabolic process (GO:0042572)5.61190285
29left/right axis specification (GO:0070986)5.59331773
30ventricular system development (GO:0021591)5.53215812
31intraciliary transport (GO:0042073)5.34399735
32L-fucose metabolic process (GO:0042354)5.28777072
33L-fucose catabolic process (GO:0042355)5.28777072
34fucose catabolic process (GO:0019317)5.28777072
35lung epithelium development (GO:0060428)5.28130625
36production of molecular mediator of immune response (GO:0002440)5.19520281
37thyroid hormone metabolic process (GO:0042403)5.11949144
38progesterone metabolic process (GO:0042448)5.10263720
39cilium organization (GO:0044782)5.01471469
40cilium assembly (GO:0042384)4.88454677
41primary alcohol metabolic process (GO:0034308)4.87863640
42phosphatidylserine acyl-chain remodeling (GO:0036150)4.84928373
43tolerance induction (GO:0002507)4.82262375
44thyroid hormone generation (GO:0006590)4.81079575
45intestinal absorption (GO:0050892)4.67385586
46establishment of apical/basal cell polarity (GO:0035089)4.57422201
47glomerular epithelial cell development (GO:0072310)4.56809040
48negative regulation of T cell differentiation in thymus (GO:0033085)4.52570769
49phospholipid scrambling (GO:0017121)4.51332893
50polyketide metabolic process (GO:0030638)4.48922521
51doxorubicin metabolic process (GO:0044598)4.48922521
52daunorubicin metabolic process (GO:0044597)4.48922521
53regulation of pH (GO:0006885)4.46869274
54* protein O-linked glycosylation (GO:0006493)4.40258534
55glutathione metabolic process (GO:0006749)4.35474379
56sulfur amino acid catabolic process (GO:0000098)4.34569881
57protein localization to cilium (GO:0061512)4.27517313
58pH reduction (GO:0045851)4.26365367
59negative regulation of B cell mediated immunity (GO:0002713)4.19325407
60negative regulation of immunoglobulin mediated immune response (GO:0002890)4.19325407
61ventricular cardiac muscle cell action potential (GO:0086005)4.19123123
62leukotriene metabolic process (GO:0006691)4.16353767
63response to xenobiotic stimulus (GO:0009410)4.13284716
64sperm capacitation (GO:0048240)4.11488321
65phosphatidylserine metabolic process (GO:0006658)4.09840440
66centriole assembly (GO:0098534)4.08140070
67leukotriene biosynthetic process (GO:0019370)4.02582901
68xenobiotic metabolic process (GO:0006805)3.99469859
69aminoglycoside antibiotic metabolic process (GO:0030647)3.98786743
70positive regulation of tolerance induction (GO:0002645)3.96999575
71negative regulation of humoral immune response (GO:0002921)3.96543267
72microtubule-based movement (GO:0007018)3.95849062
73phosphatidylinositol acyl-chain remodeling (GO:0036149)3.92402802
74establishment of monopolar cell polarity (GO:0061162)3.91387288
75establishment or maintenance of monopolar cell polarity (GO:0061339)3.91387288
76neutrophil mediated immunity (GO:0002446)3.88339202
77cellular component assembly involved in morphogenesis (GO:0010927)3.86769413
78phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.82017394
79receptor recycling (GO:0001881)3.81687888
80extracellular negative regulation of signal transduction (GO:1900116)3.81686800
81extracellular regulation of signal transduction (GO:1900115)3.81686800
82regulation of germinal center formation (GO:0002634)3.77852167
83diacylglycerol metabolic process (GO:0046339)3.73177981
84lung secretory cell differentiation (GO:0061140)3.72509811
85nitric oxide biosynthetic process (GO:0006809)3.72219255
86regulation of microtubule-based movement (GO:0060632)3.65387295
87cell projection assembly (GO:0030031)3.65351946
88cyclooxygenase pathway (GO:0019371)3.64090578
89arachidonic acid secretion (GO:0050482)3.62135388
90icosanoid secretion (GO:0032309)3.62135388
91fatty acid derivative transport (GO:1901571)3.61003456
92icosanoid transport (GO:0071715)3.61003456
93cellular response to gonadotropin stimulus (GO:0071371)3.59220296
94retinal metabolic process (GO:0042574)3.59065798
95positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.53967092
96regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.52346875
97cellular response to arsenic-containing substance (GO:0071243)3.52087225
98cytoplasmic microtubule organization (GO:0031122)3.51368756
99oligosaccharide biosynthetic process (GO:0009312)3.49222050
100C21-steroid hormone metabolic process (GO:0008207)3.47875034
101phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.46727464
102cilium morphogenesis (GO:0060271)3.46465468
103acid secretion (GO:0046717)3.45305293
104acrosome reaction (GO:0007340)3.44160031
105ethanol oxidation (GO:0006069)3.43888687
106regulation of heart rate by cardiac conduction (GO:0086091)3.41893352
107cobalamin metabolic process (GO:0009235)3.41516627
108intestinal epithelial cell development (GO:0060576)3.38197946
109alditol phosphate metabolic process (GO:0052646)3.37027720
110ear development (GO:0043583)3.36481429
111protein retention in ER lumen (GO:0006621)3.36250163
112establishment of tissue polarity (GO:0007164)3.35841035
113establishment of planar polarity (GO:0001736)3.35841035
114regulation of interleukin-5 production (GO:0032674)3.35501755
115removal of superoxide radicals (GO:0019430)3.35087060
116cellular response to superoxide (GO:0071451)3.35087060
117cellular response to oxygen radical (GO:0071450)3.35087060
118cellular aldehyde metabolic process (GO:0006081)3.29284146
119hydrogen peroxide biosynthetic process (GO:0050665)3.26907042
120growth hormone secretion (GO:0030252)3.25573972
121exogenous drug catabolic process (GO:0042738)3.24904579
122negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.24346516
123atrioventricular valve morphogenesis (GO:0003181)3.23676220
124positive regulation of smoothened signaling pathway (GO:0045880)3.22342449
125multicellular organismal water homeostasis (GO:0050891)3.22033348
126maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.17420804
127columnar/cuboidal epithelial cell differentiation (GO:0002065)3.14634858
128apical protein localization (GO:0045176)3.13813940
129cytoskeletal anchoring at plasma membrane (GO:0007016)3.12430927
130L-serine transport (GO:0015825)3.11936093
131negative regulation of inclusion body assembly (GO:0090084)3.09284292
132nucleoside diphosphate phosphorylation (GO:0006165)3.06856652
133renal absorption (GO:0070293)3.04397865
134sodium ion export (GO:0071436)3.03973047
135myeloid leukocyte mediated immunity (GO:0002444)3.03600795
136vitamin transport (GO:0051180)3.03384427
137regulation of macrophage activation (GO:0043030)3.03142525
138cardiac conduction (GO:0061337)3.02289243
139lateral sprouting from an epithelium (GO:0060601)3.02236436
140fucose metabolic process (GO:0006004)3.02095991
141excretion (GO:0007588)3.02037606
142monovalent inorganic cation homeostasis (GO:0055067)3.00058359
143nucleoside bisphosphate metabolic process (GO:0033865)2.97360624
144purine nucleoside bisphosphate metabolic process (GO:0034032)2.97360624
145ribonucleoside bisphosphate metabolic process (GO:0033875)2.97360624
146regulation of skeletal muscle contraction (GO:0014819)2.95438602
147response to superoxide (GO:0000303)2.94326523
148regulation of tolerance induction (GO:0002643)2.94214382
149hypotonic response (GO:0006971)2.93593898
150microtubule depolymerization (GO:0007019)2.93100838
151regulation of interleukin-13 production (GO:0032656)2.92223165
152reactive oxygen species biosynthetic process (GO:1903409)2.89696950
153calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.88364555
154microtubule polymerization or depolymerization (GO:0031109)2.88303535
155ATP hydrolysis coupled proton transport (GO:0015991)2.85536549
156energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.85536549
157cell communication involved in cardiac conduction (GO:0086065)2.85270440
158regulation of cardioblast differentiation (GO:0051890)2.82627861
159dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.80760173
160polyol transport (GO:0015791)2.80177373
161regulation of transforming growth factor beta1 production (GO:0032908)2.76854116
162desmosome organization (GO:0002934)2.75793612
163embryonic foregut morphogenesis (GO:0048617)2.74297841
164response to oxygen radical (GO:0000305)2.73839542
165water homeostasis (GO:0030104)2.71525410
166serine transport (GO:0032329)2.70189891
167response to gonadotropin (GO:0034698)2.69400389
168regulation of microtubule depolymerization (GO:0031114)2.68586968
169antibacterial humoral response (GO:0019731)2.68578772
170flavonoid metabolic process (GO:0009812)2.68576042
171hydrogen ion transmembrane transport (GO:1902600)2.66915633
172positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.65674392
173phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.63966771
174sodium ion homeostasis (GO:0055078)2.63881012
175nucleotide-sugar biosynthetic process (GO:0009226)2.62474355
176regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.59426525
177hormone catabolic process (GO:0042447)2.59282868
178drug catabolic process (GO:0042737)2.57834536
179xenobiotic catabolic process (GO:0042178)2.56204699
180regulation of response to osmotic stress (GO:0047484)2.54554861
181phosphatidylcholine biosynthetic process (GO:0006656)2.54388956
182glutathione biosynthetic process (GO:0006750)2.52362042
183aldehyde catabolic process (GO:0046185)2.51680067
184embryonic camera-type eye development (GO:0031076)2.49558862
185maintenance of gastrointestinal epithelium (GO:0030277)18.9294938
186axonemal dynein complex assembly (GO:0070286)18.9044239
187cilium or flagellum-dependent cell motility (GO:0001539)15.7208598
188epithelial structure maintenance (GO:0010669)14.2111694
189cilium movement (GO:0003341)13.5064689
190motile cilium assembly (GO:0044458)13.1469987
191epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)11.9637663
192primary alcohol catabolic process (GO:0034310)11.8595922
193epithelial cilium movement (GO:0003351)11.7425755
194digestion (GO:0007586)11.3935919

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_15608294_ChIP-ChIP_MCF-7_Human7.02444339
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.30965060
3SOX2_27498859_Chip-Seq_STOMACH_Mouse5.61842248
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.98681512
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.96751815
6ESR2_21235772_ChIP-Seq_MCF-7_Human3.66045556
7GATA4_25053715_ChIP-Seq_YYC3_Human2.87418319
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.63534474
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61245490
10IGF1R_20145208_ChIP-Seq_DFB_Human2.58650733
11TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.49452821
12SOX2_20726797_ChIP-Seq_SW620_Human2.42920966
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.39790711
14ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.36069421
15PPAR_26484153_Chip-Seq_NCI-H1993_Human2.35303209
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.33637950
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.32584050
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.26610587
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23414584
20HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.18965504
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.16803900
22GATA6_25053715_ChIP-Seq_YYC3_Human2.13461523
23AHR_22903824_ChIP-Seq_MCF-7_Human2.04194302
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.85977309
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84067787
26EGR1_19032775_ChIP-ChIP_M12_Human1.80600569
27PPARA_22158963_ChIP-Seq_LIVER_Mouse1.78085895
28KLF5_25053715_ChIP-Seq_YYC3_Human1.77364523
29SMC4_20622854_ChIP-Seq_HELA_Human1.76167411
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.75734465
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.74662755
32STAT1_20625510_ChIP-Seq_HELA_Human1.74180439
33VDR_22108803_ChIP-Seq_LS180_Human1.73986475
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.73801933
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.70463603
36LXR_22158963_ChIP-Seq_LIVER_Mouse1.62610456
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.61066091
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.59471583
39PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.58127787
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.55363361
41TP63_22573176_ChIP-Seq_HFKS_Human1.54468712
42GATA3_24758297_ChIP-Seq_MCF-7_Human1.51718221
43TP63_23658742_ChIP-Seq_EP156T_Human1.50722229
44AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.50690180
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50032574
46LXR_22292898_ChIP-Seq_THP-1_Human1.49837192
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42761847
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41886524
49P63_26484246_Chip-Seq_KERATINOCYTES_Human1.40068929
50CTNNB1_20460455_ChIP-Seq_HCT116_Human1.39780148
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35409031
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34433617
53RUNX1_27514584_Chip-Seq_MCF-7_Human1.34362558
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33972316
55SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33972316
56GATA1_19941826_ChIP-Seq_K562_Human1.33047519
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.32279730
58SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.31680441
59JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29939872
60JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29049685
61FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28918144
62RACK7_27058665_Chip-Seq_MCF-7_Human1.28588263
63ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28459616
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.27165247
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24926009
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23834288
67CREB1_26743006_Chip-Seq_LNCaP_Human1.23730660
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23443712
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20057104
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.19434756
71TDRD3_21172665_ChIP-Seq_MCF-7_Human1.19302011
72BCAT_22108803_ChIP-Seq_LS180_Human1.15568094
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.14962023
74RXR_22108803_ChIP-Seq_LS180_Human1.14822034
75CTCF_27219007_Chip-Seq_Bcells_Human1.14664295
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14461329
77ZNF274_21170338_ChIP-Seq_K562_Hela1.13809950
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13540029
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13040339
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11748376
81TP53_18474530_ChIP-ChIP_U2OS_Human1.10538892
82P68_20966046_ChIP-Seq_HELA_Human1.09672873
83KDM2B_26808549_Chip-Seq_K562_Human1.08260956
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08215609
85ZNF263_19887448_ChIP-Seq_K562_Human1.05874787
86KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05075584
87KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05075584
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05075584
89CTCF_20526341_ChIP-Seq_ESCs_Human1.02449771
90* FOXA2_19822575_ChIP-Seq_HepG2_Human1.01767363
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01114585
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97763726
93SMRT_27268052_Chip-Seq_Bcells_Human0.96704374
94CJUN_26792858_Chip-Seq_BT549_Human0.96513454
95ETV1_20927104_ChIP-Seq_GIST48_Human0.96309537
96FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.95913510
97GATA2_19941826_ChIP-Seq_K562_Human0.95515212
98SMAD3_21741376_ChIP-Seq_HESCs_Human0.94299883
99SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94216089
100DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94097908
101CEBPB_22108803_ChIP-Seq_LS180_Human0.93800262
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93602158
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91866018
104CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91788152
105PHF8_20622854_ChIP-Seq_HELA_Human0.91528102
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90984335
107TCF4_18268006_ChIP-ChIP_LS174T_Human0.90480338
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90204810
109HNFA_21074721_ChIP-Seq_CACO-2_Human0.89986517
110FOXA1_25552417_ChIP-Seq_VCAP_Human0.89596629
111RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89175862
112GATA2_21666600_ChIP-Seq_HMVEC_Human0.86764102
113PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.86448034
114YY1_22570637_ChIP-Seq_MALME-3M_Human0.85975523
115MYC_19829295_ChIP-Seq_ESCs_Human0.84488997
116SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82998863
117PHF8_20622853_ChIP-Seq_HELA_Human0.82833707
118FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82660380
119P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.82549815
120TBX20_22080862_ChIP-Seq_HEART_Mouse0.82187242
121TBX20_22328084_ChIP-Seq_HEART_Mouse0.82187242
122BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81867743
123TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81638286
124NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81111919
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81111919
126ATF3_27146783_Chip-Seq_COLON_Human0.80640172
127SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.79811568
128CLOCK_20551151_ChIP-Seq_293T_Human0.79651723
129FLI1_21867929_ChIP-Seq_CD8_Mouse0.79556064
130FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.78444554
131RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.77235243
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77119616
133HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76433182
134E2F1_20622854_ChIP-Seq_HELA_Human0.76194388
135NFYA_21822215_ChIP-Seq_K562_Human0.76007314
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.75473225
137PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75006445
138SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.74937694
139P53_21459846_ChIP-Seq_SAOS-2_Human0.74841695
140EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.72884243
141TP53_16413492_ChIP-PET_HCT116_Human0.72267663
142DROSHA_22980978_ChIP-Seq_HELA_Human0.72140501

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation5.94064454
2MP0002653_abnormal_ependyma_morphology5.29609388
3MP0001664_abnormal_digestion5.11568304
4MP0000470_abnormal_stomach_morphology4.01195567
5MP0002132_abnormal_respiratory_system3.44085472
6MP0003806_abnormal_nucleotide_metabolis3.28682134
7MP0008789_abnormal_olfactory_epithelium3.12390826
8MP0001984_abnormal_olfaction3.09175691
9MP0004133_heterotaxia2.88697782
10MP0005623_abnormal_meninges_morphology2.72384466
11MP0000383_abnormal_hair_follicle2.45134383
12MP0002277_abnormal_respiratory_mucosa2.31887951
13MP0005499_abnormal_olfactory_system2.11305138
14MP0005394_taste/olfaction_phenotype2.11305138
15MP0001663_abnormal_digestive_system2.10271458
16MP0008004_abnormal_stomach_pH17.7093539
17MP0002168_other_aberrant_phenotype1.87678475
18MP0001666_abnormal_nutrient_absorption1.84933712
19MP0005381_digestive/alimentary_phenotyp1.82826601
20MP0010234_abnormal_vibrissa_follicle1.82067753
21MP0005377_hearing/vestibular/ear_phenot1.79377871
22MP0003878_abnormal_ear_physiology1.79377871
23MP0000678_abnormal_parathyroid_gland1.78099378
24MP0001765_abnormal_ion_homeostasis1.75495158
25MP0005165_increased_susceptibility_to1.69636743
26MP0002249_abnormal_larynx_morphology1.47213322
27MP0005083_abnormal_biliary_tract1.45366977
28MP0002282_abnormal_trachea_morphology1.40520656
29MP0001346_abnormal_lacrimal_gland1.39512315
30MP0005248_abnormal_Harderian_gland1.39419605
31MP0002160_abnormal_reproductive_system1.32322577
32MP0000477_abnormal_intestine_morphology1.21509585
33MP0004264_abnormal_extraembryonic_tissu1.17791105
34MP0005395_other_phenotype1.15033112
35MP0003303_peritoneal_inflammation1.14411772
36MP0000858_altered_metastatic_potential1.14370259
37MP0002233_abnormal_nose_morphology1.08174166
38MP0004883_abnormal_blood_vessel1.06668983
39MP0005164_abnormal_response_to1.06407502
40MP0003283_abnormal_digestive_organ1.05380687
41MP0010030_abnormal_orbit_morphology1.04217335
42MP0006054_spinal_hemorrhage1.03768293
43MP0005085_abnormal_gallbladder_physiolo1.01828593
44MP0003950_abnormal_plasma_membrane1.01483671
45MP0003186_abnormal_redox_activity1.01407938
46MP0000681_abnormal_thyroid_gland0.98336320
47MP0005503_abnormal_tendon_morphology0.96974229
48MP0002909_abnormal_adrenal_gland0.92896257
49MP0003705_abnormal_hypodermis_morpholog0.89514575
50MP0001485_abnormal_pinna_reflex0.85821529
51MP0003868_abnormal_feces_composition0.82623205
52MP0000462_abnormal_digestive_system0.82510342
53MP0002876_abnormal_thyroid_physiology0.81461340
54MP0002896_abnormal_bone_mineralization0.79175036
55MP0005365_abnormal_bile_salt0.77280093
56MP0009384_cardiac_valve_regurgitation0.75937898
57MP0002136_abnormal_kidney_physiology0.75848341
58MP0000490_abnormal_crypts_of0.74459801
59MP0008875_abnormal_xenobiotic_pharmacok0.73536239
60MP0004782_abnormal_surfactant_physiolog0.71824023
61MP0009379_abnormal_foot_pigmentation0.71258513
62MP0000537_abnormal_urethra_morphology0.69423152
63MP0005220_abnormal_exocrine_pancreas0.68833465
64MP0005409_darkened_coat_color0.68462953
65MP0009765_abnormal_xenobiotic_induced0.68384806
66MP0009763_increased_sensitivity_to0.66816943
67MP0005266_abnormal_metabolism0.65148400
68MP0001270_distended_abdomen0.64822930
69MP0010329_abnormal_lipoprotein_level0.64134859
70MP0002734_abnormal_mechanical_nocicepti0.63616401
71MP0003890_abnormal_embryonic-extraembry0.62717512
72MP0004484_altered_response_of0.61261264
73MP0005636_abnormal_mineral_homeostasis0.59599346
74MP0005023_abnormal_wound_healing0.59474989
75MP0004185_abnormal_adipocyte_glucose0.59215144
76MP0010155_abnormal_intestine_physiology0.56137607
77MP0002234_abnormal_pharynx_morphology0.56103803
78MP0000467_abnormal_esophagus_morphology0.55546617
79MP0002796_impaired_skin_barrier0.53436374
80MP0003075_altered_response_to0.51996338
81MP0004858_abnormal_nervous_system0.51914797
82MP0002877_abnormal_melanocyte_morpholog0.51462071
83MP0005388_respiratory_system_phenotype0.48088563
84MP0002133_abnormal_respiratory_system0.48088563
85MP0002735_abnormal_chemical_nociception0.48072078
86MP0001243_abnormal_dermal_layer0.47443974
87MP0003045_fibrosis0.46956637
88MP0002405_respiratory_system_inflammati0.46658406
89MP0003937_abnormal_limbs/digits/tail_de0.45596496
90MP0003938_abnormal_ear_development0.45317520
91MP0005389_reproductive_system_phenotype0.45196239
92MP0002116_abnormal_craniofacial_bone0.44907511
93MP0003091_abnormal_cell_migration0.44589229
94MP0002009_preneoplasia0.43955546
95MP0000026_abnormal_inner_ear0.42907112
96MP0002139_abnormal_hepatobiliary_system0.41920605
97MP0004947_skin_inflammation0.41678107
98MP0001929_abnormal_gametogenesis0.40860849
99MP0002118_abnormal_lipid_homeostasis0.40381612
100MP0003953_abnormal_hormone_level0.40291049
101MP0003566_abnormal_cell_adhesion0.39705592
102MP0009703_decreased_birth_body0.39435081
103MP0005508_abnormal_skeleton_morphology0.39362027
104MP0003698_abnormal_male_reproductive0.37225415
105MP0010678_abnormal_skin_adnexa0.36932395
106MP0003866_abnormal_defecation0.34939173
107MP0002060_abnormal_skin_morphology0.34227776
108MP0003191_abnormal_cellular_cholesterol0.34180347
109MP0001216_abnormal_epidermal_layer0.34032372
110MP0002078_abnormal_glucose_homeostasis0.33926287
111MP0005166_decreased_susceptibility_to0.33770188
112MP0002693_abnormal_pancreas_physiology0.32974764
113MP0002019_abnormal_tumor_incidence0.32541999
114MP0003724_increased_susceptibility_to0.31029559
115MP0010352_gastrointestinal_tract_polyps0.30795251
116MP0001849_ear_inflammation0.30171788
117MP0009780_abnormal_chondrocyte_physiolo0.29270845
118MP0008873_increased_physiological_sensi0.28318055
119MP0005408_hypopigmentation0.28241296
120MP0002970_abnormal_white_adipose0.27964897
121MP0001845_abnormal_inflammatory_respons0.27952634
122MP0005584_abnormal_enzyme/coenzyme_acti0.27892326
123MP0003453_abnormal_keratinocyte_physiol0.26931934
124MP0000367_abnormal_coat/_hair0.26205987
125MP0004019_abnormal_vitamin_homeostasis0.24936417
126MP0003252_abnormal_bile_duct0.24122253
127MP0009642_abnormal_blood_homeostasis0.23629671
128MP0000609_abnormal_liver_physiology0.23506824
129MP0003638_abnormal_response/metabolism_0.23354048
130MP0005319_abnormal_enzyme/_coenzyme0.22783902
131MP0004130_abnormal_muscle_cell0.22121098
132MP0004043_abnormal_pH_regulation0.21694558
133MP0005501_abnormal_skin_physiology0.21582946
134MP0003119_abnormal_digestive_system0.21418781
135MP0005376_homeostasis/metabolism_phenot0.20863891
136MP0000598_abnormal_liver_morphology0.20080275
137MP0005275_abnormal_skin_tensile0.19990704
138MP0005310_abnormal_salivary_gland0.19723568
139MP0003329_amyloid_beta_deposits0.18768584
140MP0005367_renal/urinary_system_phenotyp0.18760805
141MP0000516_abnormal_urinary_system0.18760805
142MP0010771_integument_phenotype0.17315562
143MP0000013_abnormal_adipose_tissue0.17089534
144MP0005452_abnormal_adipose_tissue0.16633817
145MP0000465_gastrointestinal_hemorrhage0.15393175
146MP0002098_abnormal_vibrissa_morphology0.15164127
147MP0008961_abnormal_basal_metabolism0.14668662
148MP0005464_abnormal_platelet_physiology0.13941721
149MP0003656_abnormal_erythrocyte_physiolo0.13929997
150MP0009931_abnormal_skin_appearance0.13526216
151MP0002837_dystrophic_cardiac_calcinosis0.13351790
152MP0009643_abnormal_urine_homeostasis0.12551914
153MP0000762_abnormal_tongue_morphology0.12223930
154MP0000613_abnormal_salivary_gland0.12111869
155MP0005332_abnormal_amino_acid0.12031503
156MP0001191_abnormal_skin_condition0.11782390
157MP0005666_abnormal_adipose_tissue0.11707770
158MP0004859_abnormal_synaptic_plasticity0.11696677
159MP0000566_synostosis0.11634050

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)9.70262721
2Chronic bronchitis (HP:0004469)8.38674623
3Bronchiectasis (HP:0002110)7.43120889
4Nasal polyposis (HP:0100582)6.75193339
5Megaloblastic anemia (HP:0001889)5.64821946
6Abnormality of the nasal mucosa (HP:0000433)5.62165430
7Abnormality of the vitamin B12 metabolism (HP:0004341)5.55525216
8Abnormality of vitamin B metabolism (HP:0004340)5.24019910
9Abnormality of vitamin metabolism (HP:0100508)4.57541751
10Bronchitis (HP:0012387)4.50607961
11Goiter (HP:0000853)4.46013667
12Palpitations (HP:0001962)4.45249679
13Gout (HP:0001997)4.37983372
14Recurrent sinusitis (HP:0011108)4.32337072
15Syncope (HP:0001279)4.29238182
16Infertility (HP:0000789)4.16932259
17Male infertility (HP:0003251)4.13116796
18Woolly hair (HP:0002224)4.10756057
19Chronic sinusitis (HP:0011109)3.95668077
20Hyperactive renin-angiotensin system (HP:0000841)3.85346080
21Recurrent otitis media (HP:0000403)3.81456015
22Ventricular fibrillation (HP:0001663)3.69465430
23Abnormality of purine metabolism (HP:0004352)3.41192182
24Occipital encephalocele (HP:0002085)3.38169735
25Intrahepatic cholestasis (HP:0001406)3.33903324
26Frequent falls (HP:0002359)3.22145712
27Arterial tortuosity (HP:0005116)3.12090829
28Pancreatic fibrosis (HP:0100732)3.06776132
29Chronic otitis media (HP:0000389)3.05921997
30True hermaphroditism (HP:0010459)3.05639262
31Atelectasis (HP:0100750)2.99501868
32Ventricular arrhythmia (HP:0004308)2.99070371
33Back pain (HP:0003418)2.84591223
34Cystic liver disease (HP:0006706)2.78713442
35Vascular tortuosity (HP:0004948)2.74852657
36Glomerulosclerosis (HP:0000096)2.74021307
37Hyperuricemia (HP:0002149)2.71972596
38Increased purine levels (HP:0004368)2.71972596
39Aortic dissection (HP:0002647)2.69113766
40Ventricular tachycardia (HP:0004756)2.61142119
41Molar tooth sign on MRI (HP:0002419)2.44207504
42Abnormality of midbrain morphology (HP:0002418)2.44207504
43Abnormality of the gastric mucosa (HP:0004295)2.41922676
44Hemorrhage of the eye (HP:0011885)2.41614217
45Pancreatic cysts (HP:0001737)2.41440423
46Flat acetabular roof (HP:0003180)2.39869942
47Nephronophthisis (HP:0000090)2.39601940
48Atrophic scars (HP:0001075)2.36221753
49Abnormality of monocarboxylic acid metabolism (HP:0010996)2.33702116
50Conjugated hyperbilirubinemia (HP:0002908)2.32507239
51Hyperkalemia (HP:0002153)2.25270519
52Micronodular cirrhosis (HP:0001413)2.23704919
53Postaxial foot polydactyly (HP:0001830)2.23273402
54Agitation (HP:0000713)2.23052672
55Vascular calcification (HP:0004934)2.22334752
56Deep venous thrombosis (HP:0002625)2.22252976
57Chronic hepatic failure (HP:0100626)2.21817742
58Renal salt wasting (HP:0000127)2.20039623
59Hemiplegia (HP:0002301)2.19597335
60Infantile muscular hypotonia (HP:0008947)2.17501534
61Axonal loss (HP:0003447)2.17221595
62Tubulointerstitial nephritis (HP:0001970)2.16503764
63Curly hair (HP:0002212)2.14413494
64Ketoacidosis (HP:0001993)2.12179234
65Sudden cardiac death (HP:0001645)2.10312263
66Decreased circulating renin level (HP:0003351)2.09712869
67Cardiovascular calcification (HP:0011915)2.08319259
68Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.07222354
69Increased variability in muscle fiber diameter (HP:0003557)2.07061948
70Abnormal cartilage morphology (HP:0002763)2.03662797
71Bell-shaped thorax (HP:0001591)2.03454206
72Milia (HP:0001056)2.01755480
73Sensorimotor neuropathy (HP:0007141)2.01313409
74Ankyloglossia (HP:0010296)2.00684404
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.2000099
76Abnormal number of erythroid precursors (HP:0012131)11.4954410
77Abnormal respiratory epithelium morphology (HP:0012253)10.9909252
78Abnormal respiratory motile cilium morphology (HP:0005938)10.9909252
79Abnormal respiratory motile cilium physiology (HP:0012261)10.7654860
80Absent/shortened dynein arms (HP:0200106)10.6535982
81Dynein arm defect of respiratory motile cilia (HP:0012255)10.6535982
82Abnormal ciliary motility (HP:0012262)10.4730638
83Abnormality of cells of the erythroid lineage (HP:0012130)10.2791218
84Rhinitis (HP:0012384)10.0778889
85Abnormality of chloride homeostasis (HP:0011422)1.97925886
86Pustule (HP:0200039)1.94292996
87Abnormality of the renal medulla (HP:0100957)1.94104926
88Focal segmental glomerulosclerosis (HP:0000097)1.93632915
89Esophageal varix (HP:0002040)1.93253691
90Paresthesia (HP:0003401)1.93143593
91Fragile nails (HP:0001808)1.93060862
92Tubulointerstitial fibrosis (HP:0005576)1.92073945
93Abnormality of nucleobase metabolism (HP:0010932)1.91447533
94Macrocytic anemia (HP:0001972)1.90171036
95Absent frontal sinuses (HP:0002688)1.89377483
96Cupped ribs (HP:0000887)1.89345513
97Generalized hypopigmentation of hair (HP:0011358)1.88756662
98Ketosis (HP:0001946)1.87999409
99Hyperaldosteronism (HP:0000859)1.86427387
100Abnormality of skeletal muscle fiber size (HP:0012084)1.84711037
101Recurrent bronchitis (HP:0002837)1.83812131
102Congenital hepatic fibrosis (HP:0002612)1.82425818
103Pili torti (HP:0003777)1.80614167
104Onycholysis (HP:0001806)1.80548403
105Plantar hyperkeratosis (HP:0007556)1.80508537
106Conjunctival hamartoma (HP:0100780)1.78955992
107Male pseudohermaphroditism (HP:0000037)1.78469800
108Hypoalphalipoproteinemia (HP:0003233)1.78032931
109Fragile skin (HP:0001030)1.76398615
110Anencephaly (HP:0002323)1.74835952
111Malnutrition (HP:0004395)1.74785205
112Cone-rod dystrophy (HP:0000548)1.74560327
113Aplasia/Hypoplasia of the spleen (HP:0010451)1.71659259
114Abnormality of renin-angiotensin system (HP:0000847)1.71556401
115Growth hormone excess (HP:0000845)1.71529093
116Seborrheic dermatitis (HP:0001051)1.71072213
117Prolonged QT interval (HP:0001657)1.70460409
118Hyperammonemia (HP:0001987)1.70442238
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.70396177
120Aortic aneurysm (HP:0004942)1.69010096
121Tubular atrophy (HP:0000092)1.68673958
122Hyperglycemia (HP:0003074)1.65707949
123Rectal prolapse (HP:0002035)1.64359324
124Abdominal distention (HP:0003270)1.64307334
125Abnormality of the distal phalanges of the toes (HP:0010182)1.64237677
126Periodontitis (HP:0000704)1.63615290
127Lethargy (HP:0001254)1.61985085
128Nephropathy (HP:0000112)1.61510198
129Restlessness (HP:0000711)1.60947887
130Macroglossia (HP:0000158)1.60731822
131Aneurysm (HP:0002617)1.60151660
132Hypoglycemic coma (HP:0001325)1.59873222
133Asplenia (HP:0001746)1.58495268
134Turricephaly (HP:0000262)1.58140662
135Hyponatremia (HP:0002902)1.57487907
136Abnormality of the Achilles tendon (HP:0005109)1.56431672
137Xanthomatosis (HP:0000991)1.55907552
138Mildly elevated creatine phosphokinase (HP:0008180)1.55827122
139Abnormality of oral frenula (HP:0000190)1.55607702
140Achilles tendon contracture (HP:0001771)1.55037383
141Germ cell neoplasia (HP:0100728)1.53587328
142Abnormality of fatty-acid metabolism (HP:0004359)1.53278454
143Hand muscle atrophy (HP:0009130)1.52802426
144Congenital, generalized hypertrichosis (HP:0004540)1.52502823
145Spastic tetraparesis (HP:0001285)1.51947898
146Spinal rigidity (HP:0003306)1.50112317
147Medial flaring of the eyebrow (HP:0010747)1.49974094
148Testicular neoplasm (HP:0010788)1.49847444
149Furrowed tongue (HP:0000221)1.48712933
150Broad metatarsal (HP:0001783)1.48182763
151Abnormality of the 1st metacarpal (HP:0010009)1.48169487
152Ectopia lentis (HP:0001083)1.47691459
153Scapular winging (HP:0003691)1.47229168
154Bifid scrotum (HP:0000048)1.45882200
155Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.45454789
156Oculomotor apraxia (HP:0000657)1.43942477
157Congenital primary aphakia (HP:0007707)1.43660770
158Glucose intolerance (HP:0000833)1.41934429
159Sclerocornea (HP:0000647)1.40642321
160Gait imbalance (HP:0002141)1.39340750
161Obstructive sleep apnea (HP:0002870)1.39142734
162Short nail (HP:0001799)1.38660690
163Taurodontia (HP:0000679)1.37258804
164Abnormality of permanent molar morphology (HP:0011071)1.37258804
165Abnormality of the dental root (HP:0006486)1.37258804
166Hypokalemic alkalosis (HP:0001949)1.36867210
167Postaxial hand polydactyly (HP:0001162)1.34031154
168Distal upper limb amyotrophy (HP:0007149)1.30608935
169Upper limb amyotrophy (HP:0009129)1.30608935
170Short thorax (HP:0010306)1.29365365
171Abnormality of molar morphology (HP:0011070)1.26358208
172Abnormality of molar (HP:0011077)1.26358208
173Abnormality of the dental pulp (HP:0006479)1.26280995
174Nephrogenic diabetes insipidus (HP:0009806)1.22917140
175Limb-girdle muscle atrophy (HP:0003797)1.21807534
176Spinal muscular atrophy (HP:0007269)1.19462244
177Short femoral neck (HP:0100864)1.19447547
178Abnormality of sodium homeostasis (HP:0010931)1.18904752
179Spinal cord compression (HP:0002176)1.18876774
180Lip pit (HP:0100267)1.18375219
181Fetal akinesia sequence (HP:0001989)1.18084195
182Stage 5 chronic kidney disease (HP:0003774)1.17080713
183Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.15834265
184Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.14518371
185Median cleft lip (HP:0000161)1.13821556
186Tubulointerstitial abnormality (HP:0001969)1.12532099
187Abnormality of the frontal sinuses (HP:0002687)1.12064367
188Popliteal pterygium (HP:0009756)1.10931317
189Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.10629151
190Stridor (HP:0010307)1.10224379
191Distal lower limb muscle weakness (HP:0009053)1.08746693
192Preaxial hand polydactyly (HP:0001177)1.08398175
193Abnormality of dentin (HP:0010299)1.07093088

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK159.46048372
2EPHA26.49552532
3MST44.71508959
4MST1R4.25129701
5SMG13.15158048
6MAPKAPK32.31066699
7TRIB32.08796468
8ERBB413.1562593
9STK241.93724913
10PKN21.90023178
11TTK1.83282018
12LRRK21.72993036
13MET1.67913567
14RIPK41.59728833
15KSR21.54884154
16MAP3K91.53199330
17PIK3CG1.46797446
18TRPM71.36611249
19PBK1.34404498
20MAP3K21.30912817
21PTK2B1.27567576
22STK101.27210849
23MARK21.26382912
24BCR1.21759419
25FER1.21100967
26NEK61.19607205
27NUAK11.17369695
28MAP2K11.13172821
29MAP2K21.11918320
30PTK61.07808477
31MYLK1.07628792
32BCKDK1.07611418
33LMTK21.03424288
34EPHA31.02651117
35STK381.01106529
36FRK1.00045966
37TBK10.97960206
38PRKG20.97050941
39ERBB30.95760852
40PNCK0.92135204
41PAK30.90847037
42ERN10.88328563
43STK390.87717293
44FYN0.84793024
45RIPK10.84620978
46PDGFRB0.84292180
47PRKCI0.81791599
48WNK40.74873928
49DDR20.71154863
50ROCK20.70200203
51TESK10.69276483
52NME10.68675189
53ZAP700.64487138
54MAP3K120.63791890
55NEK10.62901211
56TAOK10.62870310
57PDK30.62348409
58PDK40.62348409
59TLK10.61502974
60ICK0.60094966
61EEF2K0.57750874
62BRSK20.52189181
63PRKCD0.52024383
64PTK20.51870883
65EPHB10.51851271
66MAP3K80.51424132
67HIPK20.50779994
68SRC0.48743054
69BMX0.47896935
70PAK40.47266777
71PDK20.47251974
72RPS6KA20.46508070
73PDPK10.45783048
74ERBB20.45781108
75DMPK0.44606104
76ROCK10.42956591
77IRAK10.41718016
78RET0.38702299
79FGFR30.37212756
80TTN0.36230514
81NLK0.35716792
82SGK10.35426555
83PDK10.32665196
84RPS6KB20.32370670
85MATK0.30188674
86MAP3K30.29981222
87CSK0.29183208
88MAP3K130.29077546
89MAP3K10.28911914
90NTRK10.28495804
91CDK120.28066124
92GRK60.27051606
93LIMK10.27008692
94MINK10.26655226
95PDGFRA0.26644845
96DYRK1B0.26582670
97AURKA0.26084117
98EGFR0.25841766
99CAMKK10.25318876
100OXSR10.24655204
101MAPKAPK50.24500270
102FGFR40.24483143
103MAP3K100.24166092
104LATS10.24040283
105MUSK0.23514674
106KSR10.22426786
107ALK0.22200174
108PAK60.22015728
109CAMK2B0.21971550
110PAK20.21350685
111ABL10.21246406
112CDK60.21013812
113PRKAA20.20842355
114PIK3CA0.19971060
115PRKD10.19527096
116PRKCA0.19054986
117CDC42BPA0.19015041
118CDK90.18227661
119FGR0.17345184
120MAP2K60.17211127
121PRKCQ0.17072075
122TYRO30.16835259
123CAMK2D0.15989302
124JAK20.15744417
125AKT20.14609243
126STK38L0.14524857
127RPS6KA10.14238764
128PHKG10.13878305
129PHKG20.13878305
130MAP3K60.13793028
131CAMK2G0.12987290
132RPS6KC10.12845614
133RPS6KL10.12845614
134ADRBK10.12223335
135PRKACA0.11986327
136BLK0.11664557
137CDK190.11557131
138CDK50.11544079
139PRKAA10.11539229
140IGF1R0.11505034
141MAP3K70.11427758
142PAK10.10465557
143PRKD20.10362832
144EPHB20.10351302
145CAMKK20.10197732
146RAF10.09654789
147MELK0.09482655
148PRKDC0.08655863

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.25722121
2Gastric acid secretion_Homo sapiens_hsa049714.99747778
3Collecting duct acid secretion_Homo sapiens_hsa049664.47062564
4Sulfur metabolism_Homo sapiens_hsa009204.46294740
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.16677847
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005124.09746936
7Chemical carcinogenesis_Homo sapiens_hsa052043.68320020
8Amphetamine addiction_Homo sapiens_hsa050313.67053481
9Glutathione metabolism_Homo sapiens_hsa004803.26656323
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.84749311
11Fat digestion and absorption_Homo sapiens_hsa049752.58387701
12Vitamin digestion and absorption_Homo sapiens_hsa049772.12589378
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.11671426
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.94092488
15Linoleic acid metabolism_Homo sapiens_hsa005911.87233811
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.59523890
17Ether lipid metabolism_Homo sapiens_hsa005651.43819290
18Pancreatic secretion_Homo sapiens_hsa049721.42525550
19Huntingtons disease_Homo sapiens_hsa050161.39995329
20Caffeine metabolism_Homo sapiens_hsa002321.38181385
21Mineral absorption_Homo sapiens_hsa049781.36263059
22Retinol metabolism_Homo sapiens_hsa008301.32496051
23Nitrogen metabolism_Homo sapiens_hsa009101.24121525
24Fatty acid degradation_Homo sapiens_hsa000711.23626385
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17922313
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17554168
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12574529
28Sphingolipid metabolism_Homo sapiens_hsa006001.08199684
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03871105
30Thyroid hormone synthesis_Homo sapiens_hsa049181.03530175
31Propanoate metabolism_Homo sapiens_hsa006400.97042228
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89077619
33Glycerolipid metabolism_Homo sapiens_hsa005610.87347381
34Pyruvate metabolism_Homo sapiens_hsa006200.85579621
35Bile secretion_Homo sapiens_hsa049760.84575149
36Sulfur relay system_Homo sapiens_hsa041220.80884455
37Histidine metabolism_Homo sapiens_hsa003400.76444213
38Phenylalanine metabolism_Homo sapiens_hsa003600.73322843
39Butanoate metabolism_Homo sapiens_hsa006500.70898181
40Drug metabolism - other enzymes_Homo sapiens_hsa009830.68070285
41Oxidative phosphorylation_Homo sapiens_hsa001900.67973381
42Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66222228
43beta-Alanine metabolism_Homo sapiens_hsa004100.64946462
44Carbon metabolism_Homo sapiens_hsa012000.62995074
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.60733171
46Hepatitis C_Homo sapiens_hsa051600.60503719
47Arachidonic acid metabolism_Homo sapiens_hsa005900.59493743
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58944703
49Notch signaling pathway_Homo sapiens_hsa043300.58912760
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57098015
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56615095
52Fatty acid metabolism_Homo sapiens_hsa012120.56511685
53Tight junction_Homo sapiens_hsa045300.56173357
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56098558
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56089932
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.55729535
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52796755
58Vibrio cholerae infection_Homo sapiens_hsa051100.51242715
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50895892
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.50568982
61Choline metabolism in cancer_Homo sapiens_hsa052310.48857971
62Circadian rhythm_Homo sapiens_hsa047100.48687030
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48591109
64PPAR signaling pathway_Homo sapiens_hsa033200.45733437
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44846657
66Taste transduction_Homo sapiens_hsa047420.44107203
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43051185
68Amoebiasis_Homo sapiens_hsa051460.42435753
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42119766
70Thyroid cancer_Homo sapiens_hsa052160.41991768
71Arginine biosynthesis_Homo sapiens_hsa002200.41901145
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40808648
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40103808
74Tyrosine metabolism_Homo sapiens_hsa003500.39559947
75Dorso-ventral axis formation_Homo sapiens_hsa043200.38492678
76Salivary secretion_Homo sapiens_hsa049700.37993878
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.36636036
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.32841050
79Lysosome_Homo sapiens_hsa041420.32016786
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.29138114
81Ovarian steroidogenesis_Homo sapiens_hsa049130.28540945
82Tryptophan metabolism_Homo sapiens_hsa003800.28257314
83Fructose and mannose metabolism_Homo sapiens_hsa000510.27727428
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.27633166
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26471883
86Insulin resistance_Homo sapiens_hsa049310.26282962
87Pentose phosphate pathway_Homo sapiens_hsa000300.25128259
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25025446
89Hedgehog signaling pathway_Homo sapiens_hsa043400.24199426
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23809636
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22737611
92Arginine and proline metabolism_Homo sapiens_hsa003300.21620640
93Adherens junction_Homo sapiens_hsa045200.21034289
94ABC transporters_Homo sapiens_hsa020100.19596173
95Proteoglycans in cancer_Homo sapiens_hsa052050.17837167
96Estrogen signaling pathway_Homo sapiens_hsa049150.16693885
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.16349242
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16229303
99Basal cell carcinoma_Homo sapiens_hsa052170.15722408
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.15662206
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.15560298
102Cocaine addiction_Homo sapiens_hsa050300.15200646
103Olfactory transduction_Homo sapiens_hsa047400.14236220
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14226392
105Peroxisome_Homo sapiens_hsa041460.13322038
106Insulin secretion_Homo sapiens_hsa049110.13312433
107Bladder cancer_Homo sapiens_hsa052190.13272577
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13237166
109GnRH signaling pathway_Homo sapiens_hsa049120.13156907
110Renin secretion_Homo sapiens_hsa049240.12775624
111Hematopoietic cell lineage_Homo sapiens_hsa046400.12692599
112Endocytosis_Homo sapiens_hsa041440.12240792
113Cardiac muscle contraction_Homo sapiens_hsa042600.12216754
114Prostate cancer_Homo sapiens_hsa052150.11422789
115Salmonella infection_Homo sapiens_hsa051320.11165141
116Biosynthesis of amino acids_Homo sapiens_hsa012300.10915754
117Fatty acid elongation_Homo sapiens_hsa000620.10863318
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.10819460
119cAMP signaling pathway_Homo sapiens_hsa040240.10645607
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.09972838
121Dilated cardiomyopathy_Homo sapiens_hsa054140.09961010
122Cholinergic synapse_Homo sapiens_hsa047250.09715723
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.09703578
124Starch and sucrose metabolism_Homo sapiens_hsa005000.09626263
125VEGF signaling pathway_Homo sapiens_hsa043700.09616677
126Complement and coagulation cascades_Homo sapiens_hsa046100.09465193
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.09319866
128Long-term potentiation_Homo sapiens_hsa047200.09262113
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.09246376
130Focal adhesion_Homo sapiens_hsa045100.08899646
131N-Glycan biosynthesis_Homo sapiens_hsa005100.08376339
132Hippo signaling pathway_Homo sapiens_hsa043900.08028920
133Fatty acid biosynthesis_Homo sapiens_hsa000610.06697846
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.05537549
135Shigellosis_Homo sapiens_hsa051310.05157925
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.05026819
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.04980869
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.04647194
139Metabolic pathways_Homo sapiens_hsa011000.03899779
140Folate biosynthesis_Homo sapiens_hsa007900.03744981
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.03728924
142ECM-receptor interaction_Homo sapiens_hsa045120.03459411
143Endometrial cancer_Homo sapiens_hsa052130.02978216
144Axon guidance_Homo sapiens_hsa043600.02515211
145Melanogenesis_Homo sapiens_hsa049160.00326623
146Jak-STAT signaling pathway_Homo sapiens_hsa04630-0.0175136
147Pancreatic cancer_Homo sapiens_hsa05212-0.0169641
148Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0021684
149Apoptosis_Homo sapiens_hsa04210-0.0020006
150Calcium signaling pathway_Homo sapiens_hsa04020-0.0019392

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