MUC5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of G0 to G1 transition (GO:0070316)9.64656019
2epithelial structure maintenance (GO:0010669)9.29011163
3cilium or flagellum-dependent cell motility (GO:0001539)8.47546681
4axonemal dynein complex assembly (GO:0070286)8.21319882
5peptide cross-linking (GO:0018149)7.86503934
6regulation of toll-like receptor 4 signaling pathway (GO:0034143)7.56234061
7regulation of keratinocyte differentiation (GO:0045616)6.88659822
8* O-glycan processing (GO:0016266)6.64052030
9sarcoplasmic reticulum calcium ion transport (GO:0070296)6.25536125
10cilium movement (GO:0003341)6.10476071
11regulation of ARF GTPase activity (GO:0032312)5.86338011
12motile cilium assembly (GO:0044458)5.76950231
13ethanol oxidation (GO:0006069)5.72932698
14surfactant homeostasis (GO:0043129)5.66178117
15innate immune response in mucosa (GO:0002227)5.63360163
16regulation of skeletal muscle contraction (GO:0014819)5.52372158
17coronary vasculature morphogenesis (GO:0060977)5.51171623
18regulation of cardioblast proliferation (GO:0003264)5.43260259
19regulation of secondary heart field cardioblast proliferation (GO:0003266)5.43260259
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.09449105
21chemical homeostasis within a tissue (GO:0048875)4.99059387
22lung epithelium development (GO:0060428)4.94294747
23regulation of relaxation of muscle (GO:1901077)4.93319826
24muscle organ morphogenesis (GO:0048644)4.89421048
25ethanol metabolic process (GO:0006067)4.88431755
26epithelial cilium movement (GO:0003351)4.73696132
27lymph vessel development (GO:0001945)4.73668223
28keratinocyte differentiation (GO:0030216)4.70141304
29skeletal muscle contraction (GO:0003009)4.61377964
30negative regulation of toll-like receptor signaling pathway (GO:0034122)4.61269513
31sensory perception of smell (GO:0007608)4.58851515
32mucosal immune response (GO:0002385)4.50076445
33* protein O-linked glycosylation (GO:0006493)4.49723803
34trivalent inorganic anion homeostasis (GO:0072506)4.41528876
35phosphate ion homeostasis (GO:0055062)4.41528876
36C21-steroid hormone biosynthetic process (GO:0006700)4.40516386
37primary alcohol catabolic process (GO:0034310)4.36350030
38digestive system process (GO:0022600)4.30436061
39regulation of skeletal muscle cell differentiation (GO:2001014)4.30117227
40organ or tissue specific immune response (GO:0002251)4.24073780
41linoleic acid metabolic process (GO:0043651)4.20544439
42regulation of epidermal cell differentiation (GO:0045604)4.13614199
43multicellular organismal water homeostasis (GO:0050891)4.09960370
44nephron tubule morphogenesis (GO:0072078)4.09416035
45nephron epithelium morphogenesis (GO:0072088)4.09416035
46retrograde transport, vesicle recycling within Golgi (GO:0000301)4.09019991
47protein targeting to Golgi (GO:0000042)4.06935574
48outer ear morphogenesis (GO:0042473)4.05863612
49long-chain fatty acid biosynthetic process (GO:0042759)4.03802249
50ventricular system development (GO:0021591)3.89159210
51actin-myosin filament sliding (GO:0033275)3.88313604
52muscle filament sliding (GO:0030049)3.88313604
53regulation of cholesterol homeostasis (GO:2000188)3.88290620
54glucocorticoid biosynthetic process (GO:0006704)3.86494480
55tooth mineralization (GO:0034505)3.84250577
56establishment of protein localization to Golgi (GO:0072600)3.79739533
57vitamin transmembrane transport (GO:0035461)3.78948350
58cellular anion homeostasis (GO:0030002)3.78594081
59one-carbon compound transport (GO:0019755)3.78154966
60purine nucleotide salvage (GO:0032261)3.74985993
61phosphate ion transmembrane transport (GO:0035435)3.72538423
62bundle of His cell to Purkinje myocyte communication (GO:0086069)3.68444238
63actin filament capping (GO:0051693)3.63262840
64striated muscle atrophy (GO:0014891)3.62727145
65C21-steroid hormone metabolic process (GO:0008207)3.58984761
66left/right pattern formation (GO:0060972)3.57454029
67axoneme assembly (GO:0035082)3.56326542
68positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.49849240
69positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.44972113
70gas transport (GO:0015669)3.43674827
71embryonic viscerocranium morphogenesis (GO:0048703)3.42545905
72water homeostasis (GO:0030104)3.39532066
73lipoxygenase pathway (GO:0019372)3.39130305
74actin-mediated cell contraction (GO:0070252)3.35106582
75epidermal cell differentiation (GO:0009913)3.34316239
76GDP-mannose metabolic process (GO:0019673)3.33284055
77regulation of germinal center formation (GO:0002634)3.31627687
78embryonic retina morphogenesis in camera-type eye (GO:0060059)3.26860843
79negative regulation of calcium ion transmembrane transport (GO:1903170)3.22490657
80negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.22490657
81plasma membrane repair (GO:0001778)3.22433303
82polyketide metabolic process (GO:0030638)3.21687014
83doxorubicin metabolic process (GO:0044598)3.21687014
84daunorubicin metabolic process (GO:0044597)3.21687014
85protein localization to Golgi apparatus (GO:0034067)3.21268594
86regulation of apoptotic cell clearance (GO:2000425)3.20435928
87muscle atrophy (GO:0014889)3.16854330
88glomerular epithelial cell development (GO:0072310)3.16686775
89renal tubule morphogenesis (GO:0061333)3.14441638
90negative regulation of actin filament depolymerization (GO:0030835)3.13880727
91progesterone metabolic process (GO:0042448)3.13842017
92phosphate ion transport (GO:0006817)3.11216930
93desmosome organization (GO:0002934)3.10814430
94muscle cell fate commitment (GO:0042693)3.08877636
95myoblast fusion (GO:0007520)3.08469503
96activation of Rac GTPase activity (GO:0032863)3.07694352
97cytoskeletal anchoring at plasma membrane (GO:0007016)3.07196822
98semaphorin-plexin signaling pathway (GO:0071526)3.05600210
99cell volume homeostasis (GO:0006884)3.04552723
100oligosaccharide biosynthetic process (GO:0009312)3.03444857
101pyrimidine-containing compound transmembrane transport (GO:0072531)3.03190060
102negative regulation of thymocyte apoptotic process (GO:0070244)3.01883183
103syncytium formation by plasma membrane fusion (GO:0000768)3.01510058
104aminoglycoside antibiotic metabolic process (GO:0030647)2.95656119
105outflow tract septum morphogenesis (GO:0003148)2.94346126
106apical protein localization (GO:0045176)2.92494295
107establishment of skin barrier (GO:0061436)2.92129965
108myotube differentiation (GO:0014902)2.91615918
109cranial nerve morphogenesis (GO:0021602)2.90519290
110response to xenobiotic stimulus (GO:0009410)2.88699729
111actin filament-based movement (GO:0030048)2.87602389
112regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.87025458
113histamine secretion (GO:0001821)2.86650485
114regulation of epidermis development (GO:0045682)2.85767792
115regulation of water loss via skin (GO:0033561)2.85720962
116skeletal muscle adaptation (GO:0043501)2.85536639
117aorta morphogenesis (GO:0035909)2.82391637
118extracellular fibril organization (GO:0043206)2.81984475
119auditory receptor cell differentiation (GO:0042491)2.78365039
120diterpenoid biosynthetic process (GO:0016102)2.76534765
121left/right axis specification (GO:0070986)2.76002285
122pharyngeal system development (GO:0060037)2.75054540
123membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.74914862
124regulation of penile erection (GO:0060405)2.74807989
125regulation of podosome assembly (GO:0071801)2.74562451
126sensory perception of chemical stimulus (GO:0007606)2.73601923
127positive regulation of myotube differentiation (GO:0010831)2.73518611
128hemidesmosome assembly (GO:0031581)2.71152503
129hair cell differentiation (GO:0035315)2.70908595
130renal system development (GO:0072001)2.69953226
131branching involved in mammary gland duct morphogenesis (GO:0060444)2.69109156
132vocalization behavior (GO:0071625)2.68695571
133epithelial cell fate commitment (GO:0072148)2.68623850
134chemosensory behavior (GO:0007635)2.67200616
135skin morphogenesis (GO:0043589)2.65619367
136mucosal-associated lymphoid tissue development (GO:0048537)2.65258065
137Peyers patch development (GO:0048541)2.65258065
138myelin maintenance (GO:0043217)2.65032336
139sperm capacitation (GO:0048240)2.64771542
140positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.64380641
141glomerular basement membrane development (GO:0032836)2.63874252
142renal absorption (GO:0070293)2.63048093
143negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.62843283
144regulation of interleukin-13 production (GO:0032656)2.62526675
145dendritic spine organization (GO:0097061)2.62489716
146fibril organization (GO:0097435)2.61927979
147regulation of interleukin-5 production (GO:0032674)2.60003245
148regulation of toll-like receptor signaling pathway (GO:0034121)2.59450987
149negative regulation of T cell differentiation in thymus (GO:0033085)2.58198965
150fucosylation (GO:0036065)2.57881499
151striated muscle contraction (GO:0006941)2.57326761
152hormone catabolic process (GO:0042447)2.57261571
153positive regulation of protein depolymerization (GO:1901881)2.57037337
154response to vitamin E (GO:0033197)2.56905997
155macroautophagy (GO:0016236)2.56701436
156renal filtration (GO:0097205)2.54223301
157epithelial cell-cell adhesion (GO:0090136)2.54221128
158regulation of acrosome reaction (GO:0060046)2.53069649
159intestinal cholesterol absorption (GO:0030299)2.52828673
160* cellular response to retinoic acid (GO:0071300)2.52383175
161positive regulation of tolerance induction (GO:0002645)2.51362706
162creatine metabolic process (GO:0006600)2.48834128
163regulation of heart morphogenesis (GO:2000826)2.45304505
164embryonic cranial skeleton morphogenesis (GO:0048701)2.42030003
165negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.33973282
166transcytosis (GO:0045056)2.30058676
167L-ascorbic acid metabolic process (GO:0019852)2.27781918
168skeletal muscle fiber development (GO:0048741)2.26987536
169regulation of heart rate by cardiac conduction (GO:0086091)2.24041686
170establishment of apical/basal cell polarity (GO:0035089)2.23175710
171positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.22769530
172blood vessel remodeling (GO:0001974)2.22552436
173histamine transport (GO:0051608)2.22001571
174positive regulation of skeletal muscle tissue development (GO:0048643)2.21966727
175negative regulation of digestive system process (GO:0060457)2.21485034
176negative regulation of ion transmembrane transporter activity (GO:0032413)2.21256366
177ventricular cardiac muscle cell action potential (GO:0086005)2.20902128
178camera-type eye morphogenesis (GO:0048593)2.20445484
179negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.20181618
180regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.19311398
181keratinization (GO:0031424)15.7077908
182negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)13.3614228
183maintenance of gastrointestinal epithelium (GO:0030277)12.3239731
184cell wall macromolecule catabolic process (GO:0016998)10.7592448
185cell wall macromolecule metabolic process (GO:0044036)10.7592448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.00720805
2ZNF652_21678463_ChIP-ChIP_ZR75-1_Human5.13752145
3CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human4.65361363
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.96478910
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.20347616
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.01084249
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.93095167
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.54919512
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.50654103
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09502210
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.04914246
12GATA1_22025678_ChIP-Seq_K562_Human1.90754981
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89873547
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.89068311
15GATA6_25053715_ChIP-Seq_YYC3_Human1.85115517
16CLOCK_20551151_ChIP-Seq_293T_Human1.83724653
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82150201
18ZNF263_19887448_ChIP-Seq_K562_Human1.68102407
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.65578336
20FOXA2_19822575_ChIP-Seq_HepG2_Human1.55408875
21* P68_20966046_ChIP-Seq_HELA_Human1.47141982
22SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47112257
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46519420
24TP63_22573176_ChIP-Seq_HFKS_Human1.44912187
25GATA4_25053715_ChIP-Seq_YYC3_Human1.44458047
26* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43090922
27WDR5_24793694_ChIP-Seq_LNCAP_Human1.42478033
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.41762026
29* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41573672
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41284200
31CREB1_26743006_Chip-Seq_LNCaP_Human1.40129871
32* CTCF_27219007_Chip-Seq_Bcells_Human1.39654796
33SOX2_20726797_ChIP-Seq_SW620_Human1.39151420
34BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38001119
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37994896
36SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.37705004
37CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36381381
38CJUN_26792858_Chip-Seq_BT549_Human1.36233765
39VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.34291215
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32663180
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32609834
42ERG_20517297_ChIP-Seq_VCAP_Human1.31229307
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31129065
44SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30081962
45AHR_22903824_ChIP-Seq_MCF-7_Human1.27795155
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26797284
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26684726
48* RACK7_27058665_Chip-Seq_MCF-7_Human1.26069455
49* E2F1_20622854_ChIP-Seq_HELA_Human1.25640969
50AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.24903932
51DROSHA_22980978_ChIP-Seq_HELA_Human1.24411644
52GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24232235
53SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22984652
54P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21764751
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21562417
56RUNX1_27514584_Chip-Seq_MCF-7_Human1.20923883
57SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20920638
58SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20920638
59TP53_22127205_ChIP-Seq_IMR90_Human1.20558846
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19957823
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19295320
62TBX20_22080862_ChIP-Seq_HEART_Mouse1.18024978
63TBX20_22328084_ChIP-Seq_HEART_Mouse1.18024978
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17561069
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15777523
66PHF8_20622854_ChIP-Seq_HELA_Human1.15331823
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14516756
68RXR_22158963_ChIP-Seq_LIVER_Mouse1.13979179
69GATA3_24758297_ChIP-Seq_MCF-7_Human1.12562804
70LXR_22158963_ChIP-Seq_LIVER_Mouse1.11953725
71* CTCF_20526341_ChIP-Seq_ESCs_Human1.11488257
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11238172
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10613561
74SMC4_20622854_ChIP-Seq_HELA_Human1.10560146
75* BCL6_27268052_Chip-Seq_Bcells_Human1.10290445
76TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07261508
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06442848
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05889897
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05175360
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03996158
81RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03007487
82FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99818184
83RXR_22108803_ChIP-Seq_LS180_Human0.99527507
84TET1_21490601_ChIP-Seq_MESCs_Mouse0.99235045
85TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99155600
86OCT1_27270436_Chip-Seq_PROSTATE_Human0.98909287
87EP300_21415370_ChIP-Seq_HL-1_Mouse0.98260147
88OCT4_19829295_ChIP-Seq_ESCs_Human0.97540332
89TCF7_22412390_ChIP-Seq_EML_Mouse0.97370885
90TP53_23651856_ChIP-Seq_MEFs_Mouse0.97355996
91ERG_21242973_ChIP-ChIP_JURKAT_Human0.96415524
92TET1_21451524_ChIP-Seq_MESCs_Mouse0.96319033
93SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96174054
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95768786
95SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95626256
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.95523149
97GATA2_21666600_ChIP-Seq_HMVEC_Human0.95494050
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.95305657
99KLF5_25053715_ChIP-Seq_YYC3_Human0.95074413
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.94790784
101ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94331185
102SA1_27219007_Chip-Seq_Bcells_Human0.93596690
103PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93163325
104LXR_22292898_ChIP-Seq_THP-1_Human0.93133057
105RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93091671
106EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93091671
107TCF4_18268006_ChIP-ChIP_LS174T_Human0.92602495
108STAT1_20625510_ChIP-Seq_HELA_Human0.92303805
109NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92195023
110FOXH1_21741376_ChIP-Seq_ESCs_Human0.92161531
111CDX2_20551321_ChIP-Seq_CACO-2_Human0.91880554
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91484654
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90904966
114SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90773076
115* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88725512
116KDM2B_26808549_Chip-Seq_K562_Human0.88456745
117* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87657727
118PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86700389
119CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86170571
120* SA1_27219007_Chip-Seq_ERYTHROID_Human0.84567746
121DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84394518
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.82888496
123* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.82549426
124JARID2_20075857_ChIP-Seq_MESCs_Mouse0.82500549
125GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82038818
126STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81622917
127TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81599619
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81522906
129TP63_23658742_ChIP-Seq_EP156T_Human0.81462221
130AR_21572438_ChIP-Seq_LNCaP_Human0.81213570
131GATA6_21074721_ChIP-Seq_CACO-2_Human0.78844157
132EZH2_27294783_Chip-Seq_ESCs_Mouse0.78782830
133* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78337354
134SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.78063661
135EGR1_19032775_ChIP-ChIP_M12_Human0.77831946
136CSB_26484114_Chip-Seq_FIBROBLAST_Human0.77501295
137CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76909452
138NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76784984
139NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76784984
140GATA1_19941826_ChIP-Seq_K562_Human0.76727600
141ELK3_25401928_ChIP-Seq_HUVEC_Human0.76541202
142TP53_18474530_ChIP-ChIP_U2OS_Human0.76197415
143BCOR_27268052_Chip-Seq_Bcells_Human0.76129850
144BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.75736791
145FOXM1_26456572_ChIP-Seq_MCF-7_Human0.74710791
146GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.74690567

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002234_abnormal_pharynx_morphology4.77992555
2MP0002796_impaired_skin_barrier4.51741338
3MP0008004_abnormal_stomach_pH4.20540064
4MP0005275_abnormal_skin_tensile4.06824553
5MP0000566_synostosis4.02764666
6MP0008875_abnormal_xenobiotic_pharmacok3.57516504
7MP0000751_myopathy3.22685664
8MP0000467_abnormal_esophagus_morphology3.22598918
9MP0000762_abnormal_tongue_morphology2.93677696
10MP0010234_abnormal_vibrissa_follicle2.93659067
11MP0003646_muscle_fatigue2.90530524
12MP0000749_muscle_degeneration2.81723220
13MP0001666_abnormal_nutrient_absorption2.73598860
14MP0004782_abnormal_surfactant_physiolog2.66866339
15MP0003866_abnormal_defecation2.66275231
16MP0001984_abnormal_olfaction2.58398205
17MP0001879_abnormal_lymphatic_vessel2.56004396
18MP0003879_abnormal_hair_cell2.47580765
19MP0008438_abnormal_cutaneous_collagen2.39750888
20MP0005501_abnormal_skin_physiology2.35633545
21MP0001958_emphysema2.31898576
22MP0003878_abnormal_ear_physiology2.31792189
23MP0005377_hearing/vestibular/ear_phenot2.31792189
24MP0001765_abnormal_ion_homeostasis2.17895882
25MP0001664_abnormal_digestion2.09445549
26MP0002837_dystrophic_cardiac_calcinosis2.06749205
27MP0000678_abnormal_parathyroid_gland2.04292108
28MP0004185_abnormal_adipocyte_glucose2.04198221
29MP0004264_abnormal_extraembryonic_tissu2.01289902
30MP0010368_abnormal_lymphatic_system1.95235322
31MP0003091_abnormal_cell_migration1.94669663
32MP0005257_abnormal_intraocular_pressure1.91887695
33MP0004130_abnormal_muscle_cell1.85235960
34MP0010155_abnormal_intestine_physiology1.82014432
35MP0000759_abnormal_skeletal_muscle1.79080758
36MP0000371_diluted_coat_color1.70318036
37MP0000747_muscle_weakness1.69590255
38MP0002332_abnormal_exercise_endurance1.68847964
39MP0000733_abnormal_muscle_development1.67660538
40MP0004019_abnormal_vitamin_homeostasis1.67512604
41MP0004145_abnormal_muscle_electrophysio1.67261118
42MP0002106_abnormal_muscle_physiology1.67224359
43MP0003252_abnormal_bile_duct1.64808038
44MP0003566_abnormal_cell_adhesion1.62579811
45MP0009697_abnormal_copulation1.62200351
46MP0004087_abnormal_muscle_fiber1.60702166
47MP0002095_abnormal_skin_pigmentation1.55719815
48MP0002822_catalepsy1.52742941
49MP0001663_abnormal_digestive_system1.49888030
50MP0001243_abnormal_dermal_layer1.49158080
51MP0001485_abnormal_pinna_reflex1.49126035
52MP0004036_abnormal_muscle_relaxation1.49043632
53MP0000750_abnormal_muscle_regeneration1.44897578
54MP0004043_abnormal_pH_regulation1.43763751
55MP0002277_abnormal_respiratory_mucosa1.42963787
56MP0009780_abnormal_chondrocyte_physiolo1.42394955
57MP0005167_abnormal_blood-brain_barrier1.38729570
58MP0005381_digestive/alimentary_phenotyp1.35633788
59MP0003279_aneurysm1.35372606
60MP0002896_abnormal_bone_mineralization1.34218959
61MP0000470_abnormal_stomach_morphology1.32594338
62MP0005076_abnormal_cell_differentiation1.32441646
63MP0005369_muscle_phenotype1.31291810
64MP0002653_abnormal_ependyma_morphology1.31141119
65MP0005620_abnormal_muscle_contractility1.30279709
66MP0003806_abnormal_nucleotide_metabolis1.29552842
67MP0002249_abnormal_larynx_morphology1.28965802
68MP0003705_abnormal_hypodermis_morpholog1.28583425
69MP0002138_abnormal_hepatobiliary_system1.24815967
70MP0002139_abnormal_hepatobiliary_system1.23406573
71MP0005503_abnormal_tendon_morphology1.23090775
72MP0002909_abnormal_adrenal_gland1.16585132
73MP0003045_fibrosis1.14654662
74MP0001177_atelectasis1.13065404
75MP0005083_abnormal_biliary_tract1.12888951
76MP0005266_abnormal_metabolism1.12191887
77MP0002168_other_aberrant_phenotype1.08989145
78MP0002254_reproductive_system_inflammat1.08728346
79MP0004133_heterotaxia1.08434908
80MP0000477_abnormal_intestine_morphology1.07593277
81MP0008961_abnormal_basal_metabolism1.04991576
82MP0005666_abnormal_adipose_tissue1.04781821
83MP0001216_abnormal_epidermal_layer1.04341361
84MP0010678_abnormal_skin_adnexa1.02987111
85MP0005023_abnormal_wound_healing1.02634557
86MP0010771_integument_phenotype1.02439505
87MP0002136_abnormal_kidney_physiology1.00902760
88MP0008995_early_reproductive_senescence0.98488090
89MP0002972_abnormal_cardiac_muscle0.97989270
90MP0002133_abnormal_respiratory_system0.97182672
91MP0005388_respiratory_system_phenotype0.97182672
92MP0005409_darkened_coat_color0.97179334
93MP0000465_gastrointestinal_hemorrhage0.94745406
94MP0003950_abnormal_plasma_membrane0.94670456
95MP0005365_abnormal_bile_salt0.94504265
96MP0002876_abnormal_thyroid_physiology0.94177849
97MP0000343_altered_response_to0.94048156
98MP0002269_muscular_atrophy0.93905277
99MP0001346_abnormal_lacrimal_gland0.93812459
100MP0002132_abnormal_respiratory_system0.93648176
101MP0000026_abnormal_inner_ear0.92413795
102MP0001661_extended_life_span0.89273410
103MP0003283_abnormal_digestive_organ0.89220331
104MP0009643_abnormal_urine_homeostasis0.88173155
105MP0002127_abnormal_cardiovascular_syste0.88150171
106MP0004084_abnormal_cardiac_muscle0.87646045
107MP0010030_abnormal_orbit_morphology0.87623532
108MP0001270_distended_abdomen0.86908416
109MP0000579_abnormal_nail_morphology0.85972367
110MP0000538_abnormal_urinary_bladder0.85427221
111MP0003075_altered_response_to0.85088015
112MP0004484_altered_response_of0.84427321
113MP0004947_skin_inflammation0.83043358
114MP0005394_taste/olfaction_phenotype0.80962070
115MP0005499_abnormal_olfactory_system0.80962070
116MP0005508_abnormal_skeleton_morphology0.80036426
117MP0003453_abnormal_keratinocyte_physiol0.79802016
118MP0008789_abnormal_olfactory_epithelium0.79402142
119MP0000613_abnormal_salivary_gland0.79257783
120MP0003191_abnormal_cellular_cholesterol0.77139628
121MP0002098_abnormal_vibrissa_morphology0.76725507
122MP0005330_cardiomyopathy0.75518272
123MP0001756_abnormal_urination0.75501528
124MP0000647_abnormal_sebaceous_gland0.74641843
125MP0000681_abnormal_thyroid_gland0.74217775
126MP0000013_abnormal_adipose_tissue0.74143561
127MP0004272_abnormal_basement_membrane0.73890473
128MP0002282_abnormal_trachea_morphology0.72594890
129MP0003329_amyloid_beta_deposits0.72460507
130MP0000383_abnormal_hair_follicle0.72057321
131MP0010630_abnormal_cardiac_muscle0.71895401
132MP0003172_abnormal_lysosome_physiology0.71808943
133MP0005165_increased_susceptibility_to0.71159439
134MP0001191_abnormal_skin_condition0.70908558
135MP0003303_peritoneal_inflammation0.70781359
136MP0009384_cardiac_valve_regurgitation0.69657408
137MP0001544_abnormal_cardiovascular_syste0.69590181
138MP0005385_cardiovascular_system_phenoty0.69590181
139MP0005375_adipose_tissue_phenotype0.69368099
140MP0002233_abnormal_nose_morphology0.68604586
141MP0009840_abnormal_foam_cell0.66599871
142MP0010386_abnormal_urinary_bladder0.65582257
143MP0000432_abnormal_head_morphology0.65540751
144MP0005636_abnormal_mineral_homeostasis0.65368383
145MP0005058_abnormal_lysosome_morphology0.64968404
146MP0001542_abnormal_bone_strength0.64804408
147MP0000462_abnormal_digestive_system0.63467858
148MP0005248_abnormal_Harderian_gland0.63100055
149MP0002060_abnormal_skin_morphology0.61977340
150MP0004858_abnormal_nervous_system0.61660417
151MP0006138_congestive_heart_failure0.61562577
152MP0001849_ear_inflammation0.61522916
153MP0002295_abnormal_pulmonary_circulatio0.61450248
154MP0001963_abnormal_hearing_physiology0.61348638
155MP0003183_abnormal_peptide_metabolism0.56511435
156MP0002108_abnormal_muscle_morphology0.56425737
157MP0001502_abnormal_circadian_rhythm0.54485839
158MP0001873_stomach_inflammation0.53677257

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.02680477
2Distal arthrogryposis (HP:0005684)5.72939908
3Exercise-induced myalgia (HP:0003738)5.46592839
4Muscle fiber inclusion bodies (HP:0100299)5.46486701
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.43770650
6Abnormal respiratory motile cilium morphology (HP:0005938)5.26955024
7Abnormal respiratory epithelium morphology (HP:0012253)5.26955024
8Abnormal respiratory motile cilium physiology (HP:0012261)5.14567529
9Abnormal ciliary motility (HP:0012262)5.09517569
10Round ear (HP:0100830)5.08940990
11Absent/shortened dynein arms (HP:0200106)4.97742717
12Dynein arm defect of respiratory motile cilia (HP:0012255)4.97742717
13Nemaline bodies (HP:0003798)4.84004216
14Pili torti (HP:0003777)4.61586431
15Rhinitis (HP:0012384)4.57148361
16Type 1 muscle fiber predominance (HP:0003803)4.46681051
17Increased connective tissue (HP:0009025)4.41961705
18Muscle hypertrophy of the lower extremities (HP:0008968)4.40417587
19Exercise-induced muscle cramps (HP:0003710)4.35529364
20Ulnar deviation of the wrist (HP:0003049)4.33187655
21Calf muscle hypertrophy (HP:0008981)4.32387802
22Difficulty running (HP:0009046)4.25395068
23Abnormality of dentin (HP:0010299)4.24978010
24Autoimmune thrombocytopenia (HP:0001973)4.13955981
25Thin bony cortex (HP:0002753)4.12222893
26Nasal polyposis (HP:0100582)4.02946720
27Hyporeflexia of lower limbs (HP:0002600)3.95871703
28Absent phalangeal crease (HP:0006109)3.94364682
29Unilateral renal agenesis (HP:0000122)3.93901346
30Right ventricular cardiomyopathy (HP:0011663)3.91855899
31Distal upper limb amyotrophy (HP:0007149)3.82634255
32Upper limb amyotrophy (HP:0009129)3.82634255
33Myoglobinuria (HP:0002913)3.77815871
34Myopathic facies (HP:0002058)3.76060666
35Bronchiectasis (HP:0002110)3.75662866
36Hyperkalemia (HP:0002153)3.74819854
37Calcaneovalgus deformity (HP:0001848)3.74241073
38Muscle fiber splitting (HP:0003555)3.70610439
39Hemorrhage of the eye (HP:0011885)3.70029097
40Hyperactive renin-angiotensin system (HP:0000841)3.69276317
41Increased IgE level (HP:0003212)3.64092849
42Cerebral aneurysm (HP:0004944)3.58160652
43Male infertility (HP:0003251)3.51505319
44Distal lower limb muscle weakness (HP:0009053)3.50202463
45Congenital malformation of the right heart (HP:0011723)3.46660445
46Double outlet right ventricle (HP:0001719)3.46660445
47Increased variability in muscle fiber diameter (HP:0003557)3.45096568
48Rimmed vacuoles (HP:0003805)3.38815323
49Abnormality of the distal phalanges of the toes (HP:0010182)3.35212335
50Abnormal finger flexion creases (HP:0006143)3.33654010
51Broad face (HP:0000283)3.32751749
52Deformed tarsal bones (HP:0008119)3.29282327
53Mask-like facies (HP:0000298)3.26974087
54Abnormality of skeletal muscle fiber size (HP:0012084)3.25055540
55Autoimmune hemolytic anemia (HP:0001890)3.13325490
56Chronic bronchitis (HP:0004469)3.13195897
57Mesangial abnormality (HP:0001966)3.11206545
58Abnormal hair laboratory examination (HP:0003328)3.09517258
59Flat acetabular roof (HP:0003180)3.04598741
60Short nail (HP:0001799)3.01831283
61Nuclear cataract (HP:0100018)3.00120622
62Abnormality of the parathyroid morphology (HP:0011766)2.97511877
63Palpebral edema (HP:0100540)2.96779329
64Tetany (HP:0001281)2.96668070
65Bilateral sensorineural hearing impairment (HP:0008619)2.95035707
66Malnutrition (HP:0004395)2.93592724
67Enlarged epiphyses (HP:0010580)2.92351701
68Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.89841083
69Interstitial pulmonary disease (HP:0006530)2.89072513
70Tibial bowing (HP:0002982)2.79442743
71Fragile skin (HP:0001030)2.72448224
72Congenital ichthyosiform erythroderma (HP:0007431)2.71887090
73Abnormality of the calf musculature (HP:0001430)2.71169628
74Abnormality of the aortic arch (HP:0012303)2.70953724
75EMG: myopathic abnormalities (HP:0003458)2.70004144
76Hand muscle atrophy (HP:0009130)2.69300829
77Polycythemia (HP:0001901)2.68617515
78Muscle stiffness (HP:0003552)2.64377916
79Gout (HP:0001997)2.64073995
80Bronchitis (HP:0012387)2.63104944
81Hyperthyroidism (HP:0000836)2.60281446
82Cupped ribs (HP:0000887)2.57385507
83Onycholysis (HP:0001806)2.56345899
84Cystic liver disease (HP:0006706)2.54405330
85Distal lower limb amyotrophy (HP:0008944)2.53462935
86Congenital sensorineural hearing impairment (HP:0008527)2.52800769
87Frequent falls (HP:0002359)2.51078351
88Obstructive sleep apnea (HP:0002870)2.50277792
89Paralysis (HP:0003470)2.49698525
90Myotonia (HP:0002486)2.49215834
91Atrophic scars (HP:0001075)2.48200149
92Cholelithiasis (HP:0001081)2.46720861
93Neonatal short-limb short stature (HP:0008921)2.45496704
94Difficulty climbing stairs (HP:0003551)2.43606933
95Areflexia of lower limbs (HP:0002522)2.43377136
96Hypophosphatemic rickets (HP:0004912)2.42399045
97Delayed epiphyseal ossification (HP:0002663)2.41161192
98Hypoplastic left heart (HP:0004383)2.39557686
99Spinal muscular atrophy (HP:0007269)2.33095350
100Cervical subluxation (HP:0003308)2.32106415
101Renal salt wasting (HP:0000127)2.27659725
102Self-mutilation (HP:0000742)2.25989818
103Atelectasis (HP:0100750)2.25896218
104Infertility (HP:0000789)2.25752093
105Neck muscle weakness (HP:0000467)2.22870859
106Premature rupture of membranes (HP:0001788)2.21253003
107Abnormality of the nasal mucosa (HP:0000433)2.20780677
108Urethral obstruction (HP:0000796)2.20037383
109Stridor (HP:0010307)2.19843109
110Decreased circulating renin level (HP:0003351)2.19074046
111Facial diplegia (HP:0001349)2.18305784
112Abnormal gallbladder morphology (HP:0012437)2.16852780
113Seborrheic dermatitis (HP:0001051)2.15634606
114Tubulointerstitial nephritis (HP:0001970)2.15307181
115Hyperacusis (HP:0010780)2.13566244
116B lymphocytopenia (HP:0010976)2.13469096
117Abnormality of B cell number (HP:0010975)2.13469096
118Abnormality of the dental pulp (HP:0006479)2.12960724
119Broad metatarsal (HP:0001783)2.10504222
120Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.10265844
121Abnormality of the calcaneus (HP:0008364)2.09796353
122Arterial tortuosity (HP:0005116)2.08908050
123Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.07963419
124Short 1st metacarpal (HP:0010034)2.07963419
125Abnormality of the 1st metacarpal (HP:0010009)2.05482241
126Recurrent otitis media (HP:0000403)2.03702712
127Scapular winging (HP:0003691)2.02823328
128Chronic sinusitis (HP:0011109)2.02182437
129Exotropia (HP:0000577)2.01183014
130Palpitations (HP:0001962)2.01151135
131Lower limb amyotrophy (HP:0007210)2.01102918
132Hyperaldosteronism (HP:0000859)2.00519260
133Oral leukoplakia (HP:0002745)10.1324444
134Hypoplastic ischia (HP:0003175)1.99279435
135Rhabdomyolysis (HP:0003201)1.98877360
136Corneal erosion (HP:0200020)1.98708674
137Abnormality of the costochondral junction (HP:0000919)1.97276653
138Widely patent fontanelles and sutures (HP:0004492)1.97013432
139Ulnar bowing (HP:0003031)1.94406581
140Aneurysm (HP:0002617)1.93874214
141Aortic dissection (HP:0002647)1.93323555
142Tubulointerstitial fibrosis (HP:0005576)1.93063991
143Protrusio acetabuli (HP:0003179)1.92927385
144Lip pit (HP:0100267)1.91494411
145Abnormality of monocarboxylic acid metabolism (HP:0010996)1.88920399
146Woolly hair (HP:0002224)1.86452052
147Bronchomalacia (HP:0002780)1.86442258
148Spinal rigidity (HP:0003306)1.85337718
149Conjugated hyperbilirubinemia (HP:0002908)1.83959989
150Diaphragmatic weakness (HP:0009113)1.83112418
151Morphological abnormality of the middle ear (HP:0008609)1.82017795
152Foot dorsiflexor weakness (HP:0009027)1.80971210
153Bell-shaped thorax (HP:0001591)1.80187855
154Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79581527
155Occipital encephalocele (HP:0002085)1.78887991
156Abnormality of potassium homeostasis (HP:0011042)1.78483841
157Femoral bowing (HP:0002980)1.77833753
158Vascular tortuosity (HP:0004948)1.76811958
159Preauricular pit (HP:0004467)1.75504787
160Periauricular skin pits (HP:0100277)1.75504787
161Mildly elevated creatine phosphokinase (HP:0008180)1.75330004
162Tarsal synostosis (HP:0008368)1.74395023
163Abnormality of renin-angiotensin system (HP:0000847)1.74254742
164Milia (HP:0001056)1.73067855
165Axonal loss (HP:0003447)1.72904647
166Long clavicles (HP:0000890)1.72844348
167Abnormality of chloride homeostasis (HP:0011422)1.71929269
168Short palpebral fissure (HP:0012745)1.71017238
169Abnormality of the ischium (HP:0003174)1.70849929
170Wrist flexion contracture (HP:0001239)1.68948476
171Abnormal trabecular bone morphology (HP:0100671)1.68723063
172Ureteral duplication (HP:0000073)1.68698142
173Muscular dystrophy (HP:0003560)1.68378713
174Hypoplastic heart (HP:0001961)1.68178769
175Nasal speech (HP:0001611)1.67881308
176Palmoplantar keratoderma (HP:0000982)1.66972982
177Hematochezia (HP:0002573)1.66905614
178Focal segmental glomerulosclerosis (HP:0000097)1.65830629
179Hyponatremia (HP:0002902)1.65642322
180Glomerulosclerosis (HP:0000096)1.65129471
181Joint laxity (HP:0001388)1.63292552
182Alopecia of scalp (HP:0002293)1.62004246
183Spondylolisthesis (HP:0003302)1.61563728
184Premature skin wrinkling (HP:0100678)1.59950102
185Hypoplasia of dental enamel (HP:0006297)1.59210567

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN8.55107510
2PIK3CG3.60936439
3MET3.59281747
4TIE13.32653212
5OBSCN2.71949799
6TRIB32.54958366
7TGFBR22.42723645
8CDK122.40174599
9PHKG12.34848365
10PHKG22.34848365
11PDK42.11290143
12PDK32.11290143
13MAP2K32.05948645
14MUSK1.86576797
15NEK11.80768930
16ERN11.65596326
17FER1.64773197
18LRRK21.64368770
19PINK11.64008493
20PDK21.60949783
21ERBB31.58047570
22MST41.55470774
23FGFR21.54882812
24DMPK1.51836793
25LATS11.42896003
26MAP3K71.39690013
27TAOK11.38832632
28MAPKAPK31.35017454
29RIPK11.31317039
30EPHB11.29014297
31SIK11.26030907
32MAP3K31.24064204
33TYRO31.23485870
34MAP3K21.18589589
35SMG11.16626526
36MAP3K131.14380188
37EPHB21.14163027
38FGFR41.10635572
39CDC42BPA1.06777971
40BCKDK1.00083604
41PRKD10.99219209
42MARK20.95260845
43PTK60.95223125
44TRPM70.94664417
45PKN20.93899520
46PDGFRA0.93544974
47NEK20.89337937
48STK100.88000075
49DAPK20.86177606
50MAP3K60.85378654
51CAMK1D0.78801391
52MAPK120.78621425
53MAP2K40.77127817
54MST1R0.76865984
55KSR20.75340287
56WNK40.73661626
57BLK0.73444882
58CAMK1G0.73181297
59MATK0.71327008
60PDGFRB0.70325697
61MTOR0.69812468
62MAP2K60.69086180
63FGFR30.68889733
64SGK30.68709075
65EPHA20.64930991
66MAPK150.63382901
67NME10.61456617
68STK390.59346024
69RPS6KB20.59225205
70PRKD30.57852903
71PDPK10.57486016
72PRKD20.56910686
73PAK40.56770245
74MAP2K20.56693382
75PAK30.56518512
76NTRK10.55478711
77HIPK20.55137130
78MAP2K10.54960790
79PRKCI0.53259134
80CDK60.52123455
81RPS6KA20.50845662
82PTK20.48934034
83LMTK20.47661287
84WNK10.47541774
85MAP3K90.45125429
86ILK0.45000918
87CHUK0.44582346
88MAP3K10.44524264
89BRD40.44369798
90STK240.44360522
91NEK90.44331038
92EEF2K0.43055916
93CSK0.42652099
94PRKCH0.41498957
95ICK0.41406988
96INSRR0.40925532
97CDK90.40236215
98CAMK2A0.40231938
99TESK10.39831030
100GRK10.39698634
101SIK20.38838607
102ROCK20.38495768
103CAMK2G0.38044509
104OXSR10.37429960
105DDR20.36864443
106FGFR10.36034862
107TBK10.34295290
108RET0.31390012
109NEK60.31176812
110SGK10.30645033
111AKT20.30171963
112ZAP700.29801630
113PIK3CA0.29789763
114PRKAA20.29132965
115EPHA30.29004650
116MYLK0.28896073
117MAP4K20.28279457
118STK30.28224109
119SGK20.27991479
120EGFR0.27874498
121DYRK1B0.27808077
122SGK4940.27102359
123SGK2230.27102359
124LIMK10.26500123
125PRKG20.24602486
126ERBB20.24329394
127PRKAA10.24115422
128MAPK110.23718725
129BMX0.23206850
130RPS6KC10.22554029
131RPS6KL10.22554029
132ITK0.20756674
133MAPK10.19701830
134SRC0.19504020
135MELK0.18844514
136FYN0.17932119
137TAOK20.17072772
138PRPF4B0.16069012
139MAPK30.15954944
140PTK2B0.15389068
141PDK10.15153405
142RPS6KA60.13325034
143IGF1R0.12726440
144ROCK10.12548651
145CAMKK10.10546085

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.78093499
2Phenylalanine metabolism_Homo sapiens_hsa003603.57502522
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.51560176
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.29214400
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.98087751
6Fat digestion and absorption_Homo sapiens_hsa049752.68825947
7Histidine metabolism_Homo sapiens_hsa003402.67943642
8Fructose and mannose metabolism_Homo sapiens_hsa000512.67004097
9* Salivary secretion_Homo sapiens_hsa049702.51651116
10Chemical carcinogenesis_Homo sapiens_hsa052042.46122995
11Tyrosine metabolism_Homo sapiens_hsa003502.38210142
12beta-Alanine metabolism_Homo sapiens_hsa004102.37810773
13Olfactory transduction_Homo sapiens_hsa047402.33572887
14Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.18900685
15Fatty acid degradation_Homo sapiens_hsa000712.13093911
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.11617689
17Other glycan degradation_Homo sapiens_hsa005112.09817713
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.06099084
19Glycosaminoglycan degradation_Homo sapiens_hsa005312.05457914
20Glycerolipid metabolism_Homo sapiens_hsa005612.04359145
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.98702918
22Notch signaling pathway_Homo sapiens_hsa043301.97376809
23Glutathione metabolism_Homo sapiens_hsa004801.89543299
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83931731
25Protein digestion and absorption_Homo sapiens_hsa049741.79954414
26Arachidonic acid metabolism_Homo sapiens_hsa005901.69014029
27Galactose metabolism_Homo sapiens_hsa000521.45403968
28Propanoate metabolism_Homo sapiens_hsa006401.39607558
29Gastric acid secretion_Homo sapiens_hsa049711.38061030
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.37217400
31Oocyte meiosis_Homo sapiens_hsa041141.34923663
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30698281
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.27075143
34Renin secretion_Homo sapiens_hsa049241.17005673
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15326991
36Caffeine metabolism_Homo sapiens_hsa002321.14626143
37Dilated cardiomyopathy_Homo sapiens_hsa054141.12198911
38Sulfur metabolism_Homo sapiens_hsa009201.09683932
39Thyroid hormone synthesis_Homo sapiens_hsa049181.09241416
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09218744
41Lysine degradation_Homo sapiens_hsa003101.08356570
42Tryptophan metabolism_Homo sapiens_hsa003801.04818068
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02901586
44Phototransduction_Homo sapiens_hsa047441.00307730
45Retinol metabolism_Homo sapiens_hsa008300.99748300
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98523750
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97377508
48Choline metabolism in cancer_Homo sapiens_hsa052310.95820356
49Fatty acid metabolism_Homo sapiens_hsa012120.93671276
50Carbon metabolism_Homo sapiens_hsa012000.91526126
51Starch and sucrose metabolism_Homo sapiens_hsa005000.91292462
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89138066
53Pancreatic secretion_Homo sapiens_hsa049720.88029171
54GnRH signaling pathway_Homo sapiens_hsa049120.87364289
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86704655
56Nitrogen metabolism_Homo sapiens_hsa009100.85790047
57Tight junction_Homo sapiens_hsa045300.83588528
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82817340
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81168287
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.79888491
61Glucagon signaling pathway_Homo sapiens_hsa049220.79637106
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77735222
63Arginine biosynthesis_Homo sapiens_hsa002200.77473640
64Pyruvate metabolism_Homo sapiens_hsa006200.76752132
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76715499
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76516703
67Insulin resistance_Homo sapiens_hsa049310.76479032
68Vitamin digestion and absorption_Homo sapiens_hsa049770.75419095
69Sphingolipid metabolism_Homo sapiens_hsa006000.72220973
70Pertussis_Homo sapiens_hsa051330.71198111
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71112291
72Cardiac muscle contraction_Homo sapiens_hsa042600.71095839
73ECM-receptor interaction_Homo sapiens_hsa045120.70608721
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.70510139
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70285174
76Oxytocin signaling pathway_Homo sapiens_hsa049210.70204143
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.69780304
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.69474466
79Butanoate metabolism_Homo sapiens_hsa006500.69389343
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69117016
81Insulin signaling pathway_Homo sapiens_hsa049100.66136641
82Circadian entrainment_Homo sapiens_hsa047130.65945126
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63774751
84Adherens junction_Homo sapiens_hsa045200.63203679
85Calcium signaling pathway_Homo sapiens_hsa040200.60701522
86Hepatitis C_Homo sapiens_hsa051600.59232423
87Melanogenesis_Homo sapiens_hsa049160.58892328
88Estrogen signaling pathway_Homo sapiens_hsa049150.58162453
89Fatty acid biosynthesis_Homo sapiens_hsa000610.56637192
90Focal adhesion_Homo sapiens_hsa045100.56327414
91Bile secretion_Homo sapiens_hsa049760.56321482
92Inositol phosphate metabolism_Homo sapiens_hsa005620.55414070
93VEGF signaling pathway_Homo sapiens_hsa043700.55120763
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53191773
95PPAR signaling pathway_Homo sapiens_hsa033200.51659379
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.50940709
97Insulin secretion_Homo sapiens_hsa049110.49835824
98Alzheimers disease_Homo sapiens_hsa050100.49003078
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48386489
100Prostate cancer_Homo sapiens_hsa052150.47373499
101Glioma_Homo sapiens_hsa052140.47297189
102Small cell lung cancer_Homo sapiens_hsa052220.47215015
103Platelet activation_Homo sapiens_hsa046110.47034361
104Chronic myeloid leukemia_Homo sapiens_hsa052200.44744551
105Thyroid cancer_Homo sapiens_hsa052160.44009068
106Bladder cancer_Homo sapiens_hsa052190.42658298
107Lysosome_Homo sapiens_hsa041420.42643946
108Proteoglycans in cancer_Homo sapiens_hsa052050.42348040
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41936429
110Linoleic acid metabolism_Homo sapiens_hsa005910.41798770
111Endometrial cancer_Homo sapiens_hsa052130.41651899
112Arginine and proline metabolism_Homo sapiens_hsa003300.40991688
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38959606
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.38387705
115Rap1 signaling pathway_Homo sapiens_hsa040150.37993565
116Renal cell carcinoma_Homo sapiens_hsa052110.37649216
117Dorso-ventral axis formation_Homo sapiens_hsa043200.37369927
118Long-term potentiation_Homo sapiens_hsa047200.37099744
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.36281488
120AMPK signaling pathway_Homo sapiens_hsa041520.35620396
121Endocytosis_Homo sapiens_hsa041440.35367857
122Sulfur relay system_Homo sapiens_hsa041220.35243615
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34795504
124Amoebiasis_Homo sapiens_hsa051460.34637587
125ErbB signaling pathway_Homo sapiens_hsa040120.34413163
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.33526987
127Cocaine addiction_Homo sapiens_hsa050300.32623753
128Ovarian steroidogenesis_Homo sapiens_hsa049130.30197674
129Fatty acid elongation_Homo sapiens_hsa000620.29649760
130Complement and coagulation cascades_Homo sapiens_hsa046100.28108943
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27668467
132Type II diabetes mellitus_Homo sapiens_hsa049300.27462063
133Biosynthesis of amino acids_Homo sapiens_hsa012300.27399800
134ABC transporters_Homo sapiens_hsa020100.26838686
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26744274
136cAMP signaling pathway_Homo sapiens_hsa040240.26471100
137Axon guidance_Homo sapiens_hsa043600.26335844
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.25729454
139Vibrio cholerae infection_Homo sapiens_hsa051100.25594226
140Viral myocarditis_Homo sapiens_hsa054160.25215438
141Taste transduction_Homo sapiens_hsa047420.24564160
142Mineral absorption_Homo sapiens_hsa049780.23848564

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